ANTI-ESTROGEN DRUG PATHWAY (PW:0000835)

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Description

Estrogen is essential for female sexual development and reproductive functions and is also important in bone and cardiovascular systems and in brain functions. Estrogen has been implicated in the growth and development of breast cancers; estrogen mediated transcription is constitutively active in more than 50% of cases. Pharmacologically, two approaches have been used to counteract estrogen-driven proliferation and promote tumor regression. One is targeting the estrogen receptors to antagonize e

Pathway Diagram:

Ariadne Genomics Inc. tamoxifen aromatase inhibitor pathway --+> osteoporosis aromatase inhibitor pathway --+> arthralgia estradiol biosynthetic pathway AI side effects TAM side effects tamoxifen ---> tamoxifen pharmacodynamics pathway tamoxifen ---> tamoxifen pharmacokinetics pathway tamoxifen pharmacodynamics pathway ---| estrogen signaling pathway estrogen signaling pathway ---| breast neoplasms arthralgia osteoporosis pulmonary embolism estrogenic, agonist-like, cardiovascular tamoxifen pharmacodynamics pathway --+> venous thrombosis tamoxifen pharmacodynamics pathway --+> pulmonary embolism estradiol biosynthetic pathway ---| estrogen signaling pathway breast neoplasms tamoxifen pharmacodynamics pathway --+> estrogenic, agonist-like, cardiovascular tamoxifen pharmacodynamics pathway --+> estrogenic, agonist-like, bone aromatase inhibitors ---> aromatase inhibitor pathway venous thrombosis estrogenic, agonist-like, bone aromatase inhibitor pathway ---| estradiol biosynthetic pathway tamoxifen pharmacokinetics pathway tamoxifen pharmacodynamics pathway estrogen signaling pathway aromatase inhibitor pathway antiestrogenic, antineoplastic aromatase inhibitors
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Genes in Pathway:

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aromatase inhibitor pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:5130880
tamoxifen pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:10402751
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:10402751
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 JBrowse link 12 10,636,294 10,684,273 RGD:10402751
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:10402751
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:5130191
RGD:10402751
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:5130191
G Fmo1 flavin containing monooxygenase 1 JBrowse link 13 80,712,885 80,745,095 RGD:10402751
G Fmo3 flavin containing monooxygenase 3 JBrowse link 13 80,837,418 80,856,214 RGD:10402751
G Ncoa3 nuclear receptor coactivator 3 JBrowse link 3 162,692,176 162,788,582 RGD:5130718
G Ncor1 nuclear receptor co-repressor 1 JBrowse link 10 48,629,121 48,772,890 RGD:5130718
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:5130718
G Phb2 prohibitin 2 JBrowse link 4 157,230,769 157,235,375 RGD:5130718
G Sult1a1 sulfotransferase family 1A member 1 JBrowse link 1 198,100,586 198,104,106 RGD:10402751
tamoxifen pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:10402751
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:10402751
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 JBrowse link 12 10,636,294 10,684,273 RGD:10402751
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 JBrowse link 12 11,641,500 11,677,818 RGD:5129544
G Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 JBrowse link 12 11,053,888 11,082,742 RGD:5129544
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:10402751
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:10402751
G Fmo1 flavin containing monooxygenase 1 JBrowse link 13 80,712,885 80,745,095 RGD:10402751
G Fmo3 flavin containing monooxygenase 3 JBrowse link 13 80,837,418 80,856,214 RGD:10402751
G Sult1a1 sulfotransferase family 1A member 1 JBrowse link 1 198,100,586 198,104,106 RGD:10402751
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:5129555

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Cell Processaromatase inhibitorsaromatase inhibitors
Small Moleculetamoxifentamoxifen

Pathway Gene Annotations

References Associated with the anti-estrogen drug pathway:

Ontology Path Diagram:

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