MICRORNA PATHWAY (PW:0000808)

View Ontology Report

Description

Small non-coding RNAs have emerged as potent regulators of gene expression. Of the three classes - microRNA (miRNA), endogenous small interfering RNA (endo-siRNA) and Piwi-interacting RNA (piRNA), miRNA is the better understood system. Its main function is post-transcriptional repression of target genes. miRNAs are transcribed from individual genes or from the introns of intron-containing genes. The resulting primary miRNA transcript (pri-miRNA) contains a hairpin-loop structure with single str

Pathway Diagram:

Elsevier Inc. adenosine ---> inosine uridine ---> t-uridine PAN2-PAN3 complex CCR4-NOT complex DCP1-DCP2 complex Xrn1 Tnrc6 AGO AGO ---- Tnrc6 RISC complex DCP1-DCP2 complex ---- RISC complex GDP GTP t-uridine uridine inosine adenosine RISC complex --+> DCP1-DCP2 complex DCP1-DCP2 complex ---- Xrn1 Tarbp2 Dicer1 GTP ---> GDP Xpo5 Ran Drosha Zcchc6 Zcchc11 Adar Adarb1 Tnrc6 --+> CCR4-NOT complex Tnrc6 --+> PAN2-PAN3 complex Pabpc1 --+> PAN2-PAN3 complex Pabpc1 Pabpc1 ---- PAN2-PAN3 complex PAN2-PAN3 complex ---- Tnrc6 Pabpc1 ---- Tnrc6 RISC complex ---| translation pathway CCR4-NOT complex ---- Tnrc6 Ran ---- Xpo5 Dgcr8 ---- Drosha Tarbp2 --+> Dicer1 Dicer1 ---- Tarbp2 GDP ---- Ran GTP ---- Ran Dgcr8 spliceosome pathway RNA polymerase II transcription pathway translation pathway target translational repression target deadenylation target degradation target decapping
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Genes in Pathway:

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microRNA pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adar adenosine deaminase, RNA-specific JBrowse link 2 189,045,551 189,085,448 RGD:9850105
G Adarb1 adenosine deaminase, RNA-specific, B1 JBrowse link 20 11,972,352 12,101,022 RGD:9850105
G Ago1 argonaute 1, RISC catalytic component JBrowse link 5 144,444,390 144,479,430 RGD:4144862
G Ago2 argonaute 2, RISC catalytic component JBrowse link 7 114,339,607 114,377,277 RGD:4144862
G Ago3 argonaute 3, RISC catalytic component JBrowse link 5 144,355,792 144,436,509 RGD:4144862
G Ago4 argonaute 4, RISC catalytic component JBrowse link 5 144,501,875 144,557,165 RGD:4144862
G Cnot1 CCR4-NOT transcription complex, subunit 1 JBrowse link 19 9,668,186 9,761,605 RGD:9850101
G Cnot10 CCR4-NOT transcription complex, subunit 10 JBrowse link 8 122,634,681 122,696,466 RGD:9850101
G Cnot2 CCR4-NOT transcription complex, subunit 2 JBrowse link 7 59,526,105 59,617,307 RGD:9850101
G Cnot3 CCR4-NOT transcription complex, subunit 3 JBrowse link 1 64,130,823 64,147,066 RGD:9850101
G Cnot6 CCR4-NOT transcription complex, subunit 6 JBrowse link 10 35,144,291 35,195,126 RGD:9850101
G Cnot6l CCR4-NOT transcription complex, subunit 6-like JBrowse link 14 15,059,101 15,148,255 RGD:9850101
G Cnot7 CCR4-NOT transcription complex, subunit 7 JBrowse link 16 54,899,452 54,918,616 RGD:9850101
G Cnot8 CCR4-NOT transcription complex, subunit 8 JBrowse link 10 43,538,150 43,551,271 RGD:9850101
G Cnot9 CCR4-NOT transcription complex subunit 9 JBrowse link 9 81,783,349 81,808,815 RGD:9850101
G Dcp1b decapping mRNA 1B JBrowse link 4 151,249,654 151,287,018 RGD:9850104
G Dcp2 decapping mRNA 2 JBrowse link 18 35,489,274 35,671,676 RGD:9850104
G Ddx6 DEAD-box helicase 6 JBrowse link 8 48,924,768 48,961,394 RGD:9850104
G Dgcr8 DGCR8 microprocessor complex subunit JBrowse link 11 86,852,682 86,885,233 RGD:4144851
G Dicer1 dicer 1 ribonuclease III JBrowse link 6 128,388,084 128,453,234 RGD:4144851
G Drosha drosha ribonuclease III JBrowse link 2 62,887,267 63,000,307 RGD:4144851
G Edc3 enhancer of mRNA decapping 3 JBrowse link 8 62,482,126 62,527,665 RGD:9850104
G Edc4 enhancer of mRNA decapping 4 JBrowse link 19 37,852,659 37,864,651 RGD:9850104
G Pabpc1 poly(A) binding protein, cytoplasmic 1 JBrowse link 7 75,409,581 75,421,874 RGD:9850101
G Pan2 PAN2 poly(A) specific ribonuclease subunit JBrowse link 7 2,717,021 2,736,541 RGD:9850101
G Pan3 PAN3 poly(A) specific ribonuclease subunit JBrowse link 12 9,214,116 9,331,901 RGD:9850101
G Patl1 PAT1 homolog 1, processing body mRNA decay factor JBrowse link 1 228,337,756 228,369,719 RGD:9850104
G Ran RAN, member RAS oncogene family JBrowse link 12 31,319,556 31,324,105 RGD:4144860
G Tarbp2 TARBP2, RISC loading complex RNA binding subunit JBrowse link 7 144,121,688 144,126,860 RGD:4144851
G Tnrc6a trinucleotide repeat containing 6a JBrowse link 1 192,991,584 193,146,403 RGD:4144862
G Tnrc6b trinucleotide repeat containing 6B JBrowse link 7 121,930,610 122,147,934 RGD:4144862
G Xpo5 exportin 5 JBrowse link 9 17,125,201 17,163,170 RGD:4144860
G Zcchc11 zinc finger CCHC-type containing 11 JBrowse link 5 128,063,880 128,168,726 RGD:9850106
G Zcchc6 zinc finger CCHC-type containing 6 JBrowse link 17 5,225,854 5,279,674 RGD:9850106

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ComplexCCR4-NOT complexa major deadenylation complex
ComplexPAN2-PAN3 complexa second deadenylation complex
ComplexDCP1-DCP2 complexdecapping
Gene GroupAGOmembers of the AGO subfamily of argonaute family
Gene GroupTnrc6 (GW182)trinucleotide repeat containing 6 family members

Pathway Gene Annotations

Disease Annotations Associated with Genes in the microRNA pathway
Disease TermsGene Symbols
Acute Lung InjuryAdar
ADENOCARCINOMA OF STOMACHCnot9
Adenocarcinoma, ProstaticCnot9
Aicardi-Goutieres SyndromeAdar
Aicardi-Goutieres Syndrome 6Adar
Amyotrophic Lateral SclerosisAdarb1
Arthritis, RheumatoidDdx6
Autism Spectrum DisorderDgcr8
bladder urothelial carcinomaCnot9
Breast NeoplasmsAdar , Pabpc1 , Xpo5 , Zcchc11
CarcinomaRan
Carcinoma, HepatocellularCnot9 , Xpo5
Carcinoma, Non-Small-Cell LungXpo5
Carcinoma, Transitional CellCnot9 , Pabpc1 , Xpo5
Chemical and Drug Induced Liver InjuryPan2
CholestasisPan2
Cocaine-Related DisordersAgo2
Colorectal NeoplasmsXpo5
Diabetes Mellitus, Type 1Ran
DiGeorge SyndromeDgcr8
Dyschromatosis Symmetrica Hereditaria 1Adar
EndometriosisDicer1
Euthyroid GoiterDicer1
HIV InfectionsRan
Huntington DiseaseXpo5
Infertility, MaleCnot7 , Drosha
Ischemic Attack, TransientAdarb1
KeloidRan
Leigh DiseaseDicer1
Leukemia, MyeloidAgo2
liver cancerCnot9
Liver NeoplasmsCnot9 , Zcchc11
Malformations of Cortical Development, Group IIDrosha
Mammary Neoplasms, AnimalRan
Mammary Neoplasms, ExperimentalRan
MelanomaCnot9
Melanoma, Cutaneous Malignant, Susceptibility To, 1Cnot9
Mental DisordersDgcr8
Mental Retardation, Autosomal Recessive 50Edc3
Mesothelioma, MalignantAgo1 , Ago2
Microphthalmia, Syndromic 1Dicer1
MicrophthalmosDicer1
Microsatellite InstabilityTarbp2 , Xpo5
Multiple MyelomaXpo5
Neoplastic Syndromes, HereditaryDicer1
Nephrotic syndrome, type 2Xpo5
Neurodevelopmental DisordersTnrc6b
ObesityAdarb1
OligospermiaDicer1
OsteoarthritisRan
Pancreatic NeoplasmsXpo5
PinealomaDicer1
pineoblastomaDicer1
Pleuropulmonary BlastomaDicer1
Polycystic Ovary SyndromeAdarb1 , Tnrc6b
Precursor T-Cell Lymphoblastic Leukemia-LymphomaCnot3
Primary Ovarian InsufficiencyXpo5
Rhabdomyosarcoma, Embryonal, 2Dicer1
Sciatic NeuropathyRan
SeizuresAdarb1
Small Cell Lung CarcinomaXpo5
Spinal Cord InjuriesAdarb1
Urinary Bladder NeoplasmsPabpc1
Wilms TumorDgcr8 , Dicer1 , Drosha , Xpo5
Pathway Annotations Associated with Genes in the microRNA pathway

References Associated with the microRNA pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: