MICRORNA PATHWAY (PW:0000808)

View Ontology Report

Description

Small non-coding RNAs have emerged as potent regulators of gene expression. Of the three classes - microRNA (miRNA), endogenous small interfering RNA (endo-siRNA) and Piwi-interacting RNA (piRNA), miRNA is the better understood system. Its main function is post-transcriptional repression of target genes. miRNAs are transcribed from individual genes or from the introns of intron-containing genes. The resulting primary miRNA transcript (pri-miRNA) contains a hairpin-loop structure with single str

Pathway Diagram:

Elsevier Inc. adenosine ---> inosine uridine ---> t-uridine PAN2-PAN3 complex CCR4-NOT complex DCP1-DCP2 complex Xrn1 Tnrc6 AGO AGO ---- Tnrc6 RISC complex DCP1-DCP2 complex ---- RISC complex GDP GTP t-uridine uridine inosine adenosine RISC complex --+> DCP1-DCP2 complex DCP1-DCP2 complex ---- Xrn1 Tarbp2 Dicer1 GTP ---> GDP Xpo5 Ran Drosha Zcchc6 Zcchc11 Adar Adarb1 Tnrc6 --+> CCR4-NOT complex Tnrc6 --+> PAN2-PAN3 complex Pabpc1 --+> PAN2-PAN3 complex Pabpc1 Pabpc1 ---- PAN2-PAN3 complex PAN2-PAN3 complex ---- Tnrc6 Pabpc1 ---- Tnrc6 RISC complex ---| translation pathway CCR4-NOT complex ---- Tnrc6 Ran ---- Xpo5 Dgcr8 ---- Drosha Tarbp2 --+> Dicer1 Dicer1 ---- Tarbp2 GDP ---- Ran GTP ---- Ran Dgcr8 spliceosome pathway RNA polymerase II transcription pathway translation pathway target translational repression target deadenylation target degradation target decapping
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Genes in Pathway:

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microRNA pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adar adenosine deaminase, RNA-specific JBrowse link 2 189,045,551 189,085,448 RGD:9850105
G Adarb1 adenosine deaminase, RNA-specific, B1 JBrowse link 20 11,972,352 12,101,022 RGD:9850105
G Ago1 argonaute 1, RISC catalytic component JBrowse link 5 144,444,390 144,479,430 RGD:4144862
G Ago2 argonaute 2, RISC catalytic component JBrowse link 7 114,339,607 114,377,277 RGD:4144862
G Ago3 argonaute 3, RISC catalytic component JBrowse link 5 144,355,792 144,436,509 RGD:4144862
G Ago4 argonaute 4, RISC catalytic component JBrowse link 5 144,501,875 144,557,165 RGD:4144862
G Cnot1 CCR4-NOT transcription complex, subunit 1 JBrowse link 19 9,668,186 9,761,605 RGD:9850101
G Cnot10 CCR4-NOT transcription complex, subunit 10 JBrowse link 8 122,634,681 122,696,466 RGD:9850101
G Cnot2 CCR4-NOT transcription complex, subunit 2 JBrowse link 7 59,526,105 59,617,307 RGD:9850101
G Cnot3 CCR4-NOT transcription complex, subunit 3 JBrowse link 1 64,130,823 64,147,066 RGD:9850101
G Cnot6 CCR4-NOT transcription complex, subunit 6 JBrowse link 10 35,144,291 35,195,126 RGD:9850101
G Cnot6l CCR4-NOT transcription complex, subunit 6-like JBrowse link 14 15,059,101 15,148,255 RGD:9850101
G Cnot7 CCR4-NOT transcription complex, subunit 7 JBrowse link 16 54,899,452 54,918,616 RGD:9850101
G Cnot8 CCR4-NOT transcription complex, subunit 8 JBrowse link 10 43,538,150 43,551,271 RGD:9850101
G Cnot9 CCR4-NOT transcription complex subunit 9 JBrowse link 9 81,783,349 81,808,815 RGD:9850101
G Dcp1b decapping mRNA 1B JBrowse link 4 151,249,654 151,287,018 RGD:9850104
G Dcp2 decapping mRNA 2 JBrowse link 18 35,489,274 35,671,676 RGD:9850104
G Ddx6 DEAD-box helicase 6 JBrowse link 8 48,924,768 48,961,394 RGD:9850104
G Dgcr8 DGCR8 microprocessor complex subunit JBrowse link 11 86,852,682 86,885,233 RGD:4144851
G Dicer1 dicer 1 ribonuclease III JBrowse link 6 128,388,084 128,453,234 RGD:4144851
G Drosha drosha ribonuclease III JBrowse link 2 62,887,267 63,000,307 RGD:4144851
G Edc3 enhancer of mRNA decapping 3 JBrowse link 8 62,482,126 62,527,665 RGD:9850104
G Edc4 enhancer of mRNA decapping 4 JBrowse link 19 37,852,659 37,864,651 RGD:9850104
G Pabpc1 poly(A) binding protein, cytoplasmic 1 JBrowse link 7 75,409,581 75,421,874 RGD:9850101
G Pan2 PAN2 poly(A) specific ribonuclease subunit JBrowse link 7 2,717,021 2,736,541 RGD:9850101
G Pan3 PAN3 poly(A) specific ribonuclease subunit JBrowse link 12 9,214,116 9,331,901 RGD:9850101
G Patl1 PAT1 homolog 1, processing body mRNA decay factor JBrowse link 1 228,337,756 228,369,719 RGD:9850104
G Ran RAN, member RAS oncogene family JBrowse link 12 31,319,556 31,324,105 RGD:4144860
G Tarbp2 TARBP2, RISC loading complex RNA binding subunit JBrowse link 7 144,121,688 144,126,860 RGD:4144851
G Tnrc6a trinucleotide repeat containing 6a JBrowse link 1 192,991,584 193,146,403 RGD:4144862
G Tnrc6b trinucleotide repeat containing 6B JBrowse link 7 121,930,610 122,147,934 RGD:4144862
G Xpo5 exportin 5 JBrowse link 9 17,125,201 17,163,170 RGD:4144860
G Zcchc11 zinc finger CCHC-type containing 11 JBrowse link 5 128,063,880 128,168,726 RGD:9850106
G Zcchc6 zinc finger CCHC-type containing 6 JBrowse link 17 5,225,854 5,279,674 RGD:9850106

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ComplexCCR4-NOT complexa major deadenylation complex
ComplexPAN2-PAN3 complexa second deadenylation complex
ComplexDCP1-DCP2 complexdecapping
Gene GroupAGOmembers of the AGO subfamily of argonaute family
Gene GroupTnrc6 (GW182)trinucleotide repeat containing 6 family members

Pathway Gene Annotations

Disease Annotations Associated with Genes in the microRNA pathway
Disease TermsGene Symbols
Acute Lung InjuryAdar
Adenocarcinoma, ProstaticCnot9
Aicardi-Goutieres SyndromeAdar
Aicardi-Goutieres Syndrome 6Adar
Amyotrophic Lateral SclerosisAdarb1
Arthritis, RheumatoidDdx6
Autism Spectrum DisorderDgcr8
Breast NeoplasmsPabpc1 , Xpo5 , Zcchc11
CarcinomaRan
Carcinoma, HepatocellularCnot9 , Xpo5
Carcinoma, Non-Small-Cell LungXpo5
Carcinoma, Transitional CellPabpc1 , Xpo5
CholestasisPan2
Cocaine-Related DisordersAgo2
Colorectal NeoplasmsXpo5
Diabetes Mellitus, Type 1Ran
Drug-Induced Liver InjuryPan2
Dyschromatosis Symmetrica Hereditaria 1Adar
EndometriosisDicer1
Euthyroid GoiterDicer1
HIV InfectionsRan
Huntington DiseaseXpo5
Infertility, MaleCnot7 , Drosha
Ischemic Attack, TransientAdarb1
KeloidRan
Leukemia, MyeloidAgo2
Liver NeoplasmsCnot9 , Zcchc11
Malformations of Cortical Development, Group IIDrosha
Mammary Neoplasms, AnimalRan
Mammary Neoplasms, ExperimentalRan
MelanomaCnot9
Melanoma, Cutaneous Malignant, Susceptibility To, 1Cnot9
Mental DisordersDgcr8
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 50Edc3
Mesothelioma, MalignantAgo1 , Ago2
Microphthalmia, Syndromic 1Dicer1
Microsatellite InstabilityTarbp2 , Xpo5
Multiple MyelomaXpo5
Nephrotic Syndrome, Type 2Xpo5
Neurodevelopmental DisordersTnrc6b
ObesityAdarb1
OligospermiaDicer1
OsteoarthritisRan
Pancreatic NeoplasmsXpo5
PinealomaDicer1
Pleuropulmonary BlastomaDicer1
Polycystic Ovary SyndromeAdarb1 , Tnrc6b
Precursor T-Cell Lymphoblastic Leukemia-LymphomaCnot3
Primary Ovarian InsufficiencyXpo5
Rhabdomyosarcoma, Embryonal, 2Dicer1
Sciatic NeuropathyRan
SeizuresAdarb1
Small Cell Lung CarcinomaXpo5
Spinal Cord InjuriesAdarb1
Urinary Bladder NeoplasmsPabpc1
Pathway Annotations Associated with Genes in the microRNA pathway

References Associated with the microRNA pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: