TESTOSTERONE BIOSYNTHETIC PATHWAY (PW:0000778)

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Description

Androgen hormones are responsible for the development and maintenance of male phenotype and reproductive functions and a range of other processes in nonreproductive tissues. Testosterone, the main androgen, is primarily synthesized in the testes; others are synthesized in the adrenal gland and can be converted to testosterone in peripheral tissues. Like all steroid hormones, androgens are derived from cholesterol; their biosynthesis is tightly regulated by the hypothalamus-pituitary-gonadal axis

Pathway Diagram:

Ariadne Genomics Inc. Srd5a1 Srd5a2 Hsd17b2 Sts Sult2a1 e Cyp17a1 Por Fdx1 Fdxr e(3) Cyp11a1 cholesterol 17-hydroxypregnenolone ---> DHEA DHEA ---> DHEAS DHEAS ---> DHEA DHEA DHEAS DHEA ---> androstenediol Hsd17b3 NADP+ NADPH(3) ---> e(3) NADP+(3) NADPH(3) Star NADPH NADPH ---> e pregnenolone ---> 17-hydroxypregnenolone cholesterol ---> pregnenolone 17-hydroxypregnenolone androstenediol pregnenolone NADPH ---> NADP+ NADPH(3) ---> NADP+(3) Hsd3b2 Hsd3b1 testosterone ---> dihydrotestosterone DHEA ---> androstenedione androstenediol ---> testosterone testosterone androstenedione testosterone ---> androstenedione androstenedione ---> testosterone dihydrotestosterone
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Genes in Pathway:

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testosterone biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:2325883
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:2325883
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:2325883
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:2325883
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 JBrowse link 19 50,246,404 50,317,892 RGD:4889549
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 JBrowse link 17 1,579,319 1,610,745 RGD:2325883
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4889549
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:4889549
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:2325883
G Srd5a1 steroid 5 alpha-reductase 1 JBrowse link 1 36,320,504 36,354,694 RGD:2325883
G Srd5a2 steroid 5 alpha-reductase 2 JBrowse link 6 25,279,635 25,315,501 RGD:2325883
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:2325883
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6893583
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:2325883

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeDHEAdehydroepiandrosterone

Pathway Gene Annotations

Disease Annotations Associated with Genes in the testosterone biosynthetic pathway
Disease TermsGene Symbols
17,20-Lyase Deficiency, IsolatedCyp17a1
17-Hydroxysteroid Dehydrogenase DeficiencyHsd17b3
46, XY Disorders of Sex DevelopmentCyp11a1
Adrenal Hyperplasia 2Hsd3b2
Adrenal Hyperplasia, CongenitalCyp11a1 , Cyp17a1 , Hsd3b2 , Por , Star
Adrenal Hyperplasia, Congenital, Type 5Cyp17a1
Adrenal InsufficiencyCyp11a1
Adrenal Insufficiency, CongenitalCyp11a1
Adrenal Insufficiency, Congenital, with 46,Xy Sex ReversalCyp11a1
AlopeciaSrd5a2
Alzheimer DiseaseHsd17b3 , Hsd3b1
AmenorrheaCyp17a1 , Por
Antley-Bixler Syndrome PhenotypePor
Antley-Bixler Syndrome with Genital Anomalies and Disordered SteroidogenesisPor
ANTLEY-BIXLER SYNDROME WITHOUT GENITAL ANOMALIES OR DISORDERED STEROIDOGENESISPor
Arthritis, RheumatoidSts
Attention Deficit Disorder with HyperactivitySts
Brain InjuriesCyp11a1
Breast NeoplasmsCyp17a1 , Srd5a1 , Srd5a2
Carcinoma, HepatocellularCyp17a1 , Hsd3b2
CardiomegalyCyp11a1 , Srd5a1 , Star
Cell Transformation, NeoplasticPor
CholelithiasisCyp17a1
CryptorchidismHsd3b2 , Sts
Diabetes MellitusSrd5a2
Diabetes Mellitus, ExperimentalCyp11a1 , Star , Sts
Diabetes Mellitus, Type 2Cyp11a1 , Hsd17b3 , Hsd3b1 , Srd5a1 , Star
Disorders of Sex DevelopmentHsd17b3
Endometrial NeoplasmsCyp11a1 , Hsd17b2 , Srd5a2 , Star
EndometriosisHsd17b2 , Srd5a1 , Srd5a2
Fatty LiverSts
Fetal Growth RetardationCyp11a1 , Star
FeverStar
Gallbladder NeoplasmsCyp17a1
GliosarcomaPor
HyperglycemiaCyp11a1
HyperkalemiaCyp17a1
HyperprolactinemiaHsd3b1 , Hsd3b2 , Srd5a1 , Srd5a2
HypertensionCyp11a1 , Hsd3b1 , Hsd3b2 , Sts
Hypertension, MalignantCyp17a1
HypogonadismCyp11a1 , Cyp17a1 , Hsd3b1 , Star
HypopituitarismCyp17a1
HypospadiasHsd3b1 , Hsd3b2 , Srd5a2
HypotensionPor
HypothyroidismHsd3b1 , Srd5a1 , Star
Ichthyosis, X-LinkedSts
Infertility, FemaleCyp17a1
Infertility, MaleCyp17a1
InflammationSts
Insulin ResistanceSts
Intellectual DisabilitySrd5a1
Learning DisordersPor
Lipoid Congenital Adrenal HyperplasiaCyp11a1 , Star
Liver Cirrhosis, ExperimentalCyp17a1 , Hsd17b2 , Srd5a1 , Sult2a1
MelanomaCyp17a1
Musculoskeletal AbnormalitiesPor
NephrosisCyp11a1 , Star
Neural Tube DefectsPor
NeuralgiaCyp17a1
Non-alcoholic Fatty Liver DiseaseCyp17a1
ObesitySrd5a1 , Sts
OligomenorrheaCyp17a1
OsteoporosisCyp17a1
Ovarian CystsCyp17a1
Pancreatic NeoplasmsCyp17a1
PancreatitisFdx1
Paranoid DisordersHsd3b2
Penis AgenesisSrd5a2
Pleomorphic Xanthoastrocytoma Por
Polycystic Ovary SyndromeCyp17a1 , Hsd3b1 , Hsd3b2 , Srd5a1 , Star
Prostatic HyperplasiaSrd5a1 , Srd5a2
Prostatic NeoplasmsCyp17a1 , Hsd17b3 , Hsd3b1 , Hsd3b2 , Srd5a1 , Srd5a2 , Sult2a1
Pseudovaginal Perineoscrotal HypospadiasSrd5a2
SchizophreniaSts
Sciatic NeuropathyCyp11a1 , Cyp17a1 , Hsd3b1
SeizuresCyp11a1
Sexual Dysfunctions, PsychologicalCyp17a1
Smith-Magenis SyndromeFdxr
Status EpilepticusCyp11a1
Toe Syndactyly, Telecanthus, and Anogenital and Renal MalformationsStar
Urinary Bladder NeoplasmsPor
Weight GainSts
Pathway Annotations Associated with Genes in the testosterone biosynthetic pathway

References Associated with the testosterone biosynthetic pathway:

Ontology Path Diagram:

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Import into Pathway Studio: