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Glucocorticoid hormones affect carbohydrate (e.g. gluconeogenesis), protein and lipid metabolism, and influence the inflammatory response. Cortisol, or hydrocortisone, the main C21 glucocorticoid, is primarily synthesized in the cortex of the adrenal gland. Like all steroid hormones, glucocorticoids are derived from cholesterol; their biosynthesis is tightly regulated by the hypothalamus-pituitary-gonadal axis. The chronic steroidogenic response involves the change in the expression o

Pathway Diagram:

Ariadne Genomics Inc. 11-deoxycortisol ---> cortisol 17alpha-hydroxyprogesterone ---> 11-deoxycortisol pregnenolone ---> progesterone pregnenolone ---> 17-hydroxypregnenolone 17-hydroxypregnenolone ---> 17alpha-hydroxyprogesterone progesterone ---> 17alpha-hydroxyprogesterone NADPH(3) ---> NADP+(3) e e(3) Hsd3b1 Hsd3b2 progesterone 17-hydroxypregnenolone Cyp11b1 Fdx1 Fdxr NADPH(3) NADP+(3) Fdx1 ---> Cyp11a1 Fdx1 ---> Cyp11b1 NADP+ NADPH NADPH ---> e NADPH(3) ---> e(3) Cyp17a1 Por ---> Cyp17a1 Por Cyp21a1 Por ---> Cyp21a1 17alpha-hydroxyprogesterone 11-deoxycortisol cortisol Cyp11a1 NADPH ---> NADP+ cholesterol Star cholesterol ---> pregnenolone pregnenolone

Genes in Pathway:

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cortisol biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:4892309
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:4889549
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:4892309
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 JBrowse link 20 4,486,213 4,489,358 RGD:4889549
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:2325883
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:2325883
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4889549
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:4889549
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:4892309
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:2325883

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small Molecule17 a hydroxy Pregnenolone17-alpha-Hydroxypregnenolone

Pathway Gene Annotations

Disease Annotations Associated with Genes in the cortisol biosynthetic pathway
Disease TermsGene Symbols
17,20-Lyase Deficiency, IsolatedCyp17a1
46, XY Disorders of Sex DevelopmentCyp11a1
Adrenal Hyperplasia 2Hsd3b2
Adrenal Hyperplasia, CongenitalCyp11a1 , Cyp11b1 , Cyp17a1 , Cyp21a1 , Hsd3b2 , Por , Star
Adrenal Hyperplasia, Congenital, Type 5Cyp17a1
Adrenal InsufficiencyCyp11a1
Adrenal Insufficiency, Congenital, with 46,Xy Sex ReversalCyp11a1
Adrenocortical AdenomaCyp11b1
Alzheimer DiseaseHsd3b1
AmenorrheaCyp17a1 , Por
Antley-Bixler Syndrome PhenotypePor
Antley-Bixler Syndrome with Genital Anomalies and Disordered SteroidogenesisPor
Brain InjuriesCyp11a1
Breast NeoplasmsCyp17a1
Carcinoma, HepatocellularCyp17a1 , Hsd3b2
CardiomegalyCyp11a1 , Star
Cell Transformation, NeoplasticPor
Diabetes Mellitus, ExperimentalCyp11a1 , Star
Diabetes Mellitus, Type 2Cyp11a1 , Hsd3b1 , Star
Endometrial NeoplasmsCyp11a1 , Star
Fetal Growth RetardationCyp11a1 , Cyp11b1 , Star
Gallbladder NeoplasmsCyp17a1
HyperprolactinemiaHsd3b1 , Hsd3b2
HypertensionCyp11a1 , Cyp11b1 , Hsd3b1 , Hsd3b2
Hypertension, MalignantCyp17a1
Hypertrophy, Left VentricularCyp11b1
HypogonadismCyp11a1 , Cyp17a1 , Hsd3b1 , Star
HypospadiasHsd3b1 , Hsd3b2
HypothyroidismHsd3b1 , Star
Infertility, FemaleCyp17a1
Infertility, MaleCyp17a1
Learning DisordersPor
Lipoid Congenital Adrenal HyperplasiaCyp11a1 , Star
Liver Cirrhosis, ExperimentalCyp17a1
Melanoma, Cutaneous Malignant, Susceptibility To, 1Cyp17a1
Musculoskeletal AbnormalitiesPor
NephrosisCyp11a1 , Star
Neural Tube DefectsPor
Non-alcoholic Fatty Liver DiseaseCyp17a1
Ovarian CystsCyp17a1
Pancreatic NeoplasmsCyp17a1
Paranoid DisordersHsd3b2
Pleomorphic Xanthoastrocytoma Por
Polycystic Ovary SyndromeCyp17a1 , Hsd3b1 , Hsd3b2 , Star
Prostatic NeoplasmsCyp17a1 , Hsd3b1 , Hsd3b2
Sciatic NeuropathyCyp11a1 , Cyp17a1 , Hsd3b1
Sexual Dysfunctions, PsychologicalCyp17a1
Smith-Magenis SyndromeFdxr
Status EpilepticusCyp11a1
Toe Syndactyly, Telecanthus, and Anogenital and Renal MalformationsStar
Urinary Bladder NeoplasmsPor
Pathway Annotations Associated with Genes in the cortisol biosynthetic pathway
Phenotype Annotations Associated with Genes in the cortisol biosynthetic pathway

References Associated with the cortisol biosynthetic pathway:

Ontology Path Diagram:

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Import into Pathway Studio: