STATIN DRUG PATHWAY (PW:0000724)

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Description

Elevated levels of plasma cholesterol represent a major risk for cardiovascular diseases (CVD). Statins are a class of drugs used in the prevention of CVD. They act as competitive inhibitors of the enzyme involved in the early, rate-determining step of cholesterol biosynthetic pathway. Currently, there are 6 statins available in the United States - atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin. Lovastatin, pravastatin and simvastatin are fungus-derived; a

Pathway Diagram:

Ariadne Genomics Inc. statins adverse drug effect statin pharmacodynamics pathway --+> statin-related myopathy statin-related myopathy statin pharmacodynamics pathway --+> statin pleiotropic effect statin pharmacodynamics pathway ---| Cardiovascular Diseases statin pharmacodynamics pathway ---| cholesterol biosynthetic pathway cholesterol biosynthetic pathway Cardiovascular Diseases statin pharmacokinetics pathway statins ---> statin pharmacodynamics pathway statins ---> statin pharmacokinetics pathway statin pleiotropic effect statin pharmacodynamics pathway
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Genes in Pathway:

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statin pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acat2 acetyl-CoA acetyltransferase 2 JBrowse link 1 47,972,399 47,992,654 RGD:10402751
G Cyp51 cytochrome P450, family 51 JBrowse link 4 27,175,564 27,194,018 RGD:10402751
G Dhcr24 24-dehydrocholesterol reductase JBrowse link 5 126,164,708 126,188,926 RGD:10402751
G Ebp emopamil binding protein (sterol isomerase) JBrowse link X 15,049,394 15,055,782 RGD:10402751
G Fdft1 farnesyl diphosphate farnesyl transferase 1 JBrowse link 15 46,339,248 46,367,302 RGD:10402751
G Fdps farnesyl diphosphate synthase JBrowse link 2 188,403,595 188,413,219 RGD:10402751
G Ggps1 geranylgeranyl diphosphate synthase 1 JBrowse link 17 53,956,185 53,971,039 RGD:10402751
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:4892116
RGD:10402751
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 JBrowse link 2 52,427,351 52,445,082 RGD:10402751
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 JBrowse link 13 88,288,116 88,308,019 RGD:10402751
G Idi1 isopentenyl-diphosphate delta isomerase 1 JBrowse link 17 57,976,266 57,984,036 RGD:10402751
G Lipa lipase A, lysosomal acid type JBrowse link 1 252,816,536 252,959,348 RGD:10402751
G Lss lanosterol synthase JBrowse link 20 12,844,522 12,870,474 RGD:10402751
G Msmo1 methylsterol monooxygenase 1 JBrowse link 16 26,859,441 26,875,880 RGD:10402751
G Mvd mevalonate diphosphate decarboxylase JBrowse link 19 55,258,910 55,268,933 RGD:10402751
G Mvk mevalonate kinase JBrowse link 12 47,904,266 47,920,457 RGD:10402751
G Nsdhl NAD(P) dependent steroid dehydrogenase-like JBrowse link X 152,933,118 152,964,399 RGD:10402751
G Pmvk phosphomevalonate kinase JBrowse link 2 188,784,329 188,793,890 RGD:10402751
G Sc5d sterol-C5-desaturase JBrowse link 8 46,525,406 46,537,014 RGD:10402751
G Soat1 sterol O-acyltransferase 1 JBrowse link 13 74,035,258 74,077,759 RGD:10402751
G Sqle squalene epoxidase JBrowse link 7 99,609,929 99,624,803 RGD:10402751
G Tm7sf2 transmembrane 7 superfamily member 2 JBrowse link 1 221,426,017 221,430,340 RGD:10402751
statin pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:1598579

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeStatinsStatins are a class of drugs used in the prevention of CVD

Pathway Gene Annotations

References Associated with the statin drug pathway:

Ontology Path Diagram:

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