ANTI-DIABETIC DRUG PATHWAY (PW:0000723)

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Description

Type 2 Diabetes Mellitus (T2D) is reaching epidemic proportions worldwide. Insulin resistance, decreased insulin secretion, increased hepatic glucose production are believed to be major pathological factors. The insulin and glucagon hormones act to maintain glucose homeostasis. When the levels of circulating glucose are elevated, the pancreatic beta cells secrete insulin. Glucagon counterbalances the effects of insulin when glucose levels are diminished. The secretion of insulin from the i

Pathway Diagram:

Ariadne Genomics Inc. type 2 diabetes mellitus repaglinide nateglinide repaglinide pharmacokinetics pathway nateglinide pharmacokinetics pathway nateglinide ---> potassium channel inhibitors pharmacodynamics pathway repaglinide ---> repaglinide pharmacokinetics pathway nateglinide ---> nateglinide pharmacokinetics pathway repaglinide ---> potassium channel inhibitors pharmacodynamics pathway insulin secretion pathway potassium channel inhibitors pharmacodynamics pathway --+> insulin secretion pathway potassium channel inhibitors pharmacodynamics pathway potassium channel inhibitors pharmacodynamics pathway ---| type 2 diabetes mellitus pathway potassium channel inhibitors pharmacodynamics pathway ---| type 2 diabetes mellitus type 2 diabetes mellitus pathway
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Genes in Pathway:

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gliclazide pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:10402751
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:10402751
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 JBrowse link 8 116,154,661 116,285,643 RGD:10402751
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 JBrowse link 10 85,954,138 85,974,764 RGD:10402751
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:10402751
G Slc2a2 solute carrier family 2 member 2 JBrowse link 2 114,413,427 114,445,418 RGD:10402751
glyburide pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:10402751
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:10402751
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 JBrowse link 8 116,154,661 116,285,643 RGD:10402751
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 JBrowse link 10 85,954,138 85,974,764 RGD:10402751
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:10402751
G Slc2a2 solute carrier family 2 member 2 JBrowse link 2 114,413,427 114,445,418 RGD:10402751
metformin pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc22a1 solute carrier family 22 member 1 JBrowse link 1 48,273,639 48,300,645 RGD:7794727
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:7794727
G Slc22a3 solute carrier family 22 member 3 JBrowse link 1 48,433,079 48,521,261 RGD:7794727
G Slc29a4 solute carrier family 29 member 4 JBrowse link 12 13,914,114 13,924,511 RGD:7794727
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:7794727
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:7794727
potassium channel inhibitors pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:10402751
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:10402751
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 JBrowse link 8 116,154,661 116,285,643 RGD:10402751
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 JBrowse link 10 85,954,138 85,974,764 RGD:10402751
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:10402751
G Slc2a2 solute carrier family 2 member 2 JBrowse link 2 114,413,427 114,445,418 RGD:10402751
rosiglitazone pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 JBrowse link 1 257,676,172 258,004,428 RGD:10402751
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:10402751

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small Moleculenateglinidenateglinide
Small Moleculerepagliniderepaglinide

Pathway Gene Annotations

References Associated with the anti-diabetic drug pathway:

Ontology Path Diagram:

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