P53 SIGNALING PATHWAY (PW:0000718)

View Ontology Report

Description

The p53 tumor suppression transcription factor, many times referred to as the 'guardian of the genome' or as the 'cellular gatekeeper', is at the hub of many signaling and regulatory networks. It represents a critical node of cellular homeostasis integrating many cues emerging from exogenous and endogenous stresses and in response promoting, as necessary, cell cycle arrest, apoptosis or senescence, among others. A key signal activating the p53 pathway is DNA damage, such as double-strand breaks

Pathway Diagram:

Elsevier Inc. Mdm2 ---| Tp53 Mdm2 ---- Tp53 Tp53 ---> Mdm2 Mdm4 ---- Tp53 Mdm4 p53, Mdm2 acetylation ---> Tp53 p53 methylation ---> Tp53 ataxia telangiectasia-mutated (ATM) signaling pathway --+> Tp53 Tp53 <--> non-coding RNAs - p53 targets, regulators, effectors non-coding RNAs - p53 targets, regulators, effectors RNA polymerase II transcription initiation pathway Tp53 --+> RNA polymerase II transcription pathway p53 targets Tp53 --+> intrinsic apoptotic pathway Tp53 --+> cell cycle arrest Tp53 --+> senescence Tp53 ---> p53 targets Tp53 ---> non-coding RNAs - p53 targets, regulators, effectors p53-dependent histone acetylation RNA polymerase II transcription pathway p53-dependent histone acetylation ---- Tp53 Tp53 exogenous stress NO p53 binding partners p53 regulators p53, Mdm2 acetylation ---| Mdm2 p53, Mdm2 phosphorylation ---> Mdm2 p53, Mdm2 phosphorylation ---> Tp53 ataxia telangiectasia-mutated (ATM) signaling pathway ---> p53, Mdm2 phosphorylation p53, Mdm2 acetylation p53 methylation p53, Mdm2 phosphorylation intrinsic apoptotic pathway cell cycle arrest endogenous stress ataxia telangiectasia-mutated (ATM) signaling pathway Mdm4 ---| Tp53 exogenous stress --+> Tp53 p53 ubiquitination Mdm2 p53 binding partners ---- Tp53 Mdm2 ---- Mdm4 senescence endogenous stress --+> Tp53
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Genes in Pathway:

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p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:6484113
RGD:8662965
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link 7 115,766,484 115,828,514 RGD:6907045
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:6907045
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:2316155
RGD:2316156
RGD:6484113
RGD:6907045
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6907045
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:6907045
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:6907045
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:8662965
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6907045
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccna2 cyclin A2 JBrowse link 2 123,274,727 123,282,266 RGD:6484113
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:6907045
G Ccnb2 cyclin B2 JBrowse link 8 76,847,972 76,861,165 RGD:6907045
G Ccnb3 cyclin B3 JBrowse link X 16,300,752 16,402,206 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Ccnd2 cyclin D2 JBrowse link 4 159,674,885 159,697,207 RGD:6907045
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:6907045
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:6907045
G Ccne2 cyclin E2 JBrowse link 5 24,434,077 24,446,406 RGD:6907045
G Ccng1 cyclin G1 JBrowse link 10 25,903,925 25,910,298 RGD:6484113
RGD:6907045
G Ccng2 cyclin G2 JBrowse link 14 16,267,572 16,276,068 RGD:6907045
G Cd82 Cd82 molecule JBrowse link 3 82,324,344 82,368,846 RGD:6907045
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6907045
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6484113
RGD:6907045
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6907045
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6907045
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6907045
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6907045
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:2316155
RGD:2316156
RGD:6484113
RGD:6907045
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:2316155
RGD:2316156
RGD:6484113
RGD:6907045
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:2316155
RGD:6484113
RGD:8662965
G Cse1l chromosome segregation 1 like JBrowse link 3 163,664,074 163,702,074 RGD:6484113
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:6484113
G Csnk1d casein kinase 1, delta JBrowse link 10 110,147,786 110,182,413 RGD:6484113
G Csnk1e casein kinase 1, epsilon JBrowse link 7 120,651,976 120,675,559 RGD:6484113
G Csnk1g1 casein kinase 1, gamma 1 JBrowse link 8 71,533,372 71,688,483 RGD:6484113
G Csnk1g2 casein kinase 1, gamma 2 JBrowse link 7 11,944,957 11,963,268 RGD:6484113
G Csnk1g3 casein kinase 1, gamma 3 JBrowse link 18 48,831,209 48,913,341 RGD:6484113
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6907045
G Cyct cytochrome c, testis JBrowse link 3 63,204,779 63,211,847 RGD:6907045
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:6484113
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 JBrowse link 7 61,785,423 61,816,775 RGD:6484113
G E4f1 E4F transcription factor 1 JBrowse link 10 13,812,335 13,835,847 RGD:6484113
G Ei24 EI24, autophagy associated transmembrane protein JBrowse link 8 39,254,883 39,271,238 RGD:6907045
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6484113
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6907045
G Fbxo11 F-box protein 11 JBrowse link 6 11,662,356 11,737,427 RGD:6484113
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6907045
G Gadd45b growth arrest and DNA-damage-inducible, beta JBrowse link 7 11,646,283 11,648,338 RGD:6907045
G Gadd45g growth arrest and DNA-damage-inducible, gamma JBrowse link 17 13,391,474 13,393,219 RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6484113
G Gtse1 G-2 and S-phase expressed 1 JBrowse link 7 126,736,416 126,753,221 RGD:6907045
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:2316155
G Hipk2 homeodomain interacting protein kinase 2 JBrowse link 4 66,438,390 66,625,183 RGD:6484113
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6907045
G Igfbp3 insulin-like growth factor binding protein 3 JBrowse link 14 87,457,647 87,465,374 RGD:6907045
G Kat2a lysine acetyltransferase 2A JBrowse link 10 88,611,586 88,619,558 RGD:8662965
G Kat2b lysine acetyltransferase 2B JBrowse link 9 4,440,982 4,492,949 RGD:8662965
G Kat5 lysine acetyltransferase 5 JBrowse link 1 220,967,795 220,974,596 RGD:2316155
RGD:6484113
RGD:8662965
G Kat8 lysine acetyltransferase 8 JBrowse link 1 199,360,645 199,372,925 RGD:2316155
RGD:6484113
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6484113
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6484113
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:2316155
RGD:2316156
RGD:6484113
RGD:6907045
G Mdm4 MDM4, p53 regulator JBrowse link 13 49,786,776 49,828,780 RGD:2316155
RGD:2316156
RGD:6484113
RGD:6907045
G Muc1 mucin 1, cell surface associated JBrowse link 2 188,543,137 188,547,874 RGD:8662965
G Nedd8 neural precursor cell expressed, developmentally down-regulated 8 JBrowse link 15 34,340,607 34,352,673 RGD:6484113
G Perp PERP, TP53 apoptosis effector JBrowse link 1 14,224,392 14,236,838 RGD:6907045
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 8 21,669,236 21,680,615 RGD:6484113
RGD:8662965
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:6907045
G Pou4f1 POU class 4 homeobox 1 JBrowse link 15 88,618,255 88,622,712 RGD:8662965
G Pou4f2 POU class 4 homeobox 2 JBrowse link 19 33,160,180 33,163,821 RGD:8662965
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D JBrowse link 10 72,909,550 72,945,884 RGD:6484113
RGD:6907045
G Ppp1r13b protein phosphatase 1, regulatory subunit 13B JBrowse link 6 136,397,658 136,469,757 RGD:8662965
G Ppp1r13l protein phosphatase 1, regulatory subunit 13 like JBrowse link 1 80,271,288 80,290,946 RGD:6484113
RGD:8662965
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:6484113
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6484113
G Prmt5 protein arginine methyltransferase 5 JBrowse link 15 33,156,508 33,165,893 RGD:6484113
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:6907045
G Ptpa protein phosphatase 2 phosphatase activator JBrowse link 3 8,982,122 9,012,585 RGD:6484113
G Rassf1 Ras association domain family member 1 JBrowse link 8 116,307,149 116,318,289 RGD:6484113
G Rchy1 ring finger and CHY zinc finger domain containing 1 JBrowse link 14 17,615,968 17,631,715 RGD:2316155
RGD:6484113
RGD:6907045
G Rfwd2 ring finger and WD repeat domain 2 JBrowse link 13 76,942,883 77,076,015 RGD:6907045
G Rpl11 ribosomal protein L11 JBrowse link 5 154,390,809 154,394,412 RGD:6484113
G Rpl23 ribosomal protein L23 JBrowse link 10 85,721,398 85,725,359 RGD:6484113
G Rpl5l1 ribosomal protein L5-like 1 JBrowse link 10 112,564,193 112,565,170 RGD:6484113
G Rprm reprimo, TP53 dependent G2 arrest mediator homolog JBrowse link 3 39,595,301 39,596,718 RGD:6907045
G Rrm2 ribonucleotide reductase regulatory subunit M2 JBrowse link 6 43,884,627 43,890,818 RGD:6907045
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B JBrowse link 7 76,750,045 76,780,817 RGD:6907045
G Serpinb5 serpin family B member 5 JBrowse link 13 26,903,052 26,923,250 RGD:6907045
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6907045
G Sesn1 sestrin 1 JBrowse link 20 46,667,116 46,758,306 RGD:6907045
G Sesn3 sestrin 3 JBrowse link 8 12,823,060 12,878,749 RGD:6907045
G Setd7 SET domain containing (lysine methyltransferase) 7 JBrowse link 2 140,576,188 140,618,405 RGD:2316155
RGD:6484113
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:6907045
G Shisa5 shisa family member 5 JBrowse link 8 117,780,992 117,795,923 RGD:6907045
G Siah1 siah E3 ubiquitin protein ligase 1 JBrowse link 19 21,372,163 21,395,773 RGD:6907045
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:2316155
G Skp2 S-phase kinase associated protein 2 JBrowse link 2 58,506,146 58,534,211 RGD:6484113
G Smyd2 SET and MYND domain containing 2 JBrowse link 13 108,642,156 108,686,293 RGD:2316155
RGD:6484113
G Steap3 STEAP3 metalloreductase JBrowse link 13 36,257,220 36,274,144 RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:2316155
RGD:2316156
RGD:6484113
RGD:6907045
G Tp53bp2 tumor protein p53 binding protein, 2 JBrowse link 13 100,817,206 100,873,837 RGD:8662965
G Tp73 tumor protein p73 JBrowse link 5 171,355,876 171,415,354 RGD:6907045
G Trim28 tripartite motif-containing 28 JBrowse link 1 65,544,369 65,551,043 RGD:6484113
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:6907045
G Ttc5 tetratricopeptide repeat domain 5 JBrowse link 15 27,698,375 27,715,970 RGD:6484113
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 JBrowse link 20 18,547,370 18,580,291 RGD:6484113
G Usp7 ubiquitin specific peptidase 7 JBrowse link 10 6,930,462 7,019,910 RGD:2316155
RGD:6484113
G Ybx1 Y box binding protein 1 JBrowse link 5 138,319,754 138,336,721 RGD:8662965
G Yy1 YY1 transcription factor JBrowse link 6 132,702,443 132,726,848 RGD:6484113
G Zfp385a zinc finger protein 385A JBrowse link 7 144,939,616 144,966,364 RGD:8662965
G Zfp420 zinc finger protein 420 JBrowse link 1 88,531,975 88,564,480 RGD:8662965
G Zmat3 zinc finger, matrin type 3 JBrowse link 2 118,715,229 118,746,109 RGD:6907045
G Znhit1 zinc finger, HIT-type containing 1 JBrowse link 12 22,726,643 22,732,917 RGD:8662965
altered p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ets1 ETS proto-oncogene 1, transcription factor JBrowse link 8 33,756,634 33,879,625 RGD:8663430
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:2316186
RGD:8663434
G Mdm4 MDM4, p53 regulator JBrowse link 13 49,786,776 49,828,780 RGD:8663434
G Mre11a MRE11 homolog A, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:8663431
G Nfya nuclear transcription factor Y subunit alpha JBrowse link 9 14,551,752 14,577,002 RGD:8663430
RGD:8663431
G Nfyb nuclear transcription factor Y subunit beta JBrowse link 7 27,081,667 27,097,481 RGD:8663430
RGD:8663431
G Nfyc nuclear transcription factor Y subunit gamma JBrowse link 5 139,687,442 139,760,154 RGD:8663430
RGD:8663431
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 8 21,669,236 21,680,615 RGD:8663430
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:8663430
RGD:8663431
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:2316186
RGD:4143515
RGD:5133242
RGD:5490966
RGD:8663430
RGD:8663431
RGD:8693397
G Tp63 tumor protein p63 JBrowse link 11 78,234,853 78,456,559 RGD:8663430
RGD:8663431
G Tp73 tumor protein p73 JBrowse link 5 171,355,876 171,415,354 RGD:8663430
RGD:8663431
G Vdr vitamin D receptor JBrowse link 7 139,344,452 139,394,138 RGD:8663430

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassTp53 regulators
Functional Classp53 dependent histone acetylation
Gene Groupnon-coding RNAs - p53 targets, regulators, effectors
Gene Groupp53 binding partners
Gene Groupp53 targets
Small MoleculeNOnitric oxide

Pathway Gene Annotations

Disease Annotations Associated with Genes in the p53 signaling pathway
Disease TermsGene Symbols
2-Aminoadipic 2-Oxoadipic AciduriaChek2
Abnormalities, MultipleCrebbp , Gsk3b , Hdac1 , Pten
Abortion, SpontaneousCd82 , Igf1 , Igfbp3
Acidosis, LacticRrm2b
Acne VulgarisIgf1
AcromegalyIgf1
Acute Kidney InjuryBax , Fas , Gsk3b , Igf1 , Sirt1 , Tp53
Acute Lung InjuryBax , Fas , Serpine1
Acute-Phase ReactionIgfbp3
AdenocarcinomaAbl1 , Casp8 , Ccnd1 , Cdkn2a , Pten , Rassf1 , Tp53
Adenocarcinoma of EsophagusCdkn2a , Fas , Tp53
Adenocarcinoma of LungAkt1 , Cdk4 , Cdkn2a , Crebbp , Ep300 , Sfn , Tp53
ADENOCARCINOMA OF STOMACHAkt1 , Cdkn2a , Crebbp , Pten , Tp53
Adenocarcinoma, Bronchiolo-AlveolarTp53
Adenocarcinoma, Clear CellDaxx , Tp53
Adenocarcinoma, ColonDaxx
Adenocarcinoma, ColorectalCdkn1a
Adenocarcinoma, MucinousMuc1
Adenocarcinoma, ProstaticAkt1 , Cdkn2a , Pten , Tp53
AdenomaIgf1 , Tp53
Adenoma, Liver CellPten
Adenomatous Polyposis ColiAkt1
Adrenal Gland NeoplasmsCdkn2a , Tp53
Adrenal InsufficiencyBax
Adrenocortical CarcinomaCdkn2a , Daxx , Tp53
Adrenocortical Carcinoma, HereditaryTp53
Adrenocortical Carcinoma, PediatricTp53
Advanced Sleep Phase Syndrome, Familial, 2Csnk1d
Advanced Sleep-Phase Syndrome, Familial, 1Csnk1d
Aging, PrematureBax , Brca1 , Cdkn1a , Cdkn2a , Mdm2 , Tp53
Aicardi-Goutieres SyndromeKat5
AlbuminuriaIgf1 , Serpine1
Alcoholic NeuropathyIgf1
AlopeciaIgf1
Alopecia AreataHdac1
Alzheimer DiseaseAbl1 , Akt1 , Atm , Bax , Casp3 , Ccng1 , Crebbp , Csnk1a1 , Csnk1d , Csnk1e , Ep300 , Fas , Gsk3b , Igf1 , Igfbp3 , Mapk14 , Mapk8 , Mapk9 , Mdm4 , Sirt1 , Tp53 , Tsc2
Amphetamine-Related DisordersAkt1
AmyloidosisSerpine1
Amyotrophic Lateral SclerosisAkt1 , Casp3 , Casp9 , Gsk3b , Mapk14 , Sirt1 , Tp53
Amyotrophic Lateral Sclerosis 1Crebbp
Anemia, AplasticFas
Anemia, Diamond-BlackfanRpl11
Anemia, Hypochromic Microcytic, with Iron Overload 2Steap3
Anemia, Iron-DeficiencyKat5
Anemia, RefractoryYbx1
Anemia, Sickle CellMdm2
Angina, UnstableAkt1
AngiomyolipomaPten , Tsc2
AnisometropiaPten
AnoxiaCasp3
Anterior Wall Myocardial InfarctionSerpine1
Anti-Glomerular Basement Membrane DiseaseMapk14 , Mapk8
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisFas
Aortic AneurysmSerpine1
Aortic Aneurysm, AbdominalMapk8 , Serpine1
Aortic Aneurysm, ThoracicFas , Serpine1
Aortic RemodelingSerpine1
Aortic Valve, Calcification ofAkt1
Apraxia, Oculomotor, Cogan TypeAtm
Arsenic PoisoningCdkn1a , Gadd45b , Tp53
Arterial ThrombosisSerpine1
ArteriosclerosisAtm , Igf1 , Igfbp3 , Mapk9
Arthritis, ExperimentalAkt1 , Bax , Cdkn2a , Gsk3b , Igf1 , Igfbp3
Arthritis, JuvenileGadd45a
Arthritis, RheumatoidCdk6 , Fas , Igfbp3
AsthmaFas , Muc1 , Pin1 , Ppp2ca , Prmt5 , Pten , Serpine1
AstrocytomaAkt1 , Nedd8 , Tp53
AtaxiaAtm , Pten
Ataxia TelangiectasiaAtm
Ataxia-Telangiectasia VariantAtm
AtherosclerosisAkt1 , Serpine1 , Sirt1
Atrial FibrillationCdkn1a
Attention Deficit Disorder with HyperactivityCrebbp
Autism Spectrum DisorderTsc2
Autistic DisorderIgf1 , Igfbp3 , Pten , Rfwd2 , Serpine1 , Tsc2
Autoimmune DiseasesCasp8 , Fas , Sirt1
Autoimmune Lymphoproliferative SyndromeCasp8 , Fas
Autoimmune Lymphoproliferative Syndrome, Type IAFas
Autoimmune Lymphoproliferative Syndrome, Type IIIPrkcd
Bacterial InfectionsCasp3 , Casp8 , Casp9
Balkan NephropathyTp53
Barrett EsophagusCdkn1a , Fas , Igfbp3 , Rprm
Behcet SyndromeFas , Serpine1
Beta-ThalassemiaIgfbp3
Biliary AtresiaPten
Biliary Tract NeoplasmsMdm2 , Muc1
Binge DrinkingSirt1
Bipolar DisorderAkt1 , Gsk3b
Bird Fancier's LungMuc1
BlepharitisMuc1
Bone Diseases, DevelopmentalAbl1 , Tp53
Bone Diseases, MetabolicIgf1 , Igfbp3
Bone Marrow NeoplasmsTp53
Bowen's DiseaseCcne1 , Cdkn1a
Brain DiseasesTsc2
Brain Diseases, MetabolicFas
Brain InfarctionSirt1
Brain InjuriesAkt1 , Apaf1 , Bax , Casp3 , Casp8 , Cdkn1a , Fas , Gsk3b , Igf1 , Mdm2 , Rchy1 , Sirt1 , Skp2
Brain IschemiaAkt1 , Apaf1 , Bbc3 , Casp3 , Casp9 , Cycs , Fas , Igf1 , Mapk8 , Prkcd , Serpine1 , Tp53
Brain NeoplasmsCcnd1 , Cdk4 , Cdkn2a , Pten , Sirt1 , Tp53
Brain Stem NeoplasmsCdk4 , Cdk6 , Cdkn2a , Ppm1d
Breast AdenocarcinomaAkt1 , Tp53
Breast Cancer, FamilialAtm , Brca1 , Chek2
Breast NeoplasmsAbl1 , Akt1 , Atm , Bax , Brca1 , Casp3 , Casp8 , Casp9 , Ccnb1 , Ccnd1 , Ccnd2 , Ccnd3 , Ccne1 , Cd82 , Cdk1 , Cdk2 , Cdk4 , Cdkn1a , Cdkn2a , Chek1 , Chek2 , Ep300 , Fas , Hdac1 , Igf1 , Igfbp3 , Kat2b , Kat5 , Kat8 , Mdm2 , Mdm4 , Muc1 , Pin1 , Ppm1d , Pten , Rassf1 , Rrm2 , Serpinb5 , Serpine1 , Sirt1 , Skp2 , Tp53 , Tp73 , Tsc2
Breast Neoplasms, MaleChek2
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Brca1
Bronchiolitis ObliteransMuc1
Bronchiolitis, ViralMuc1
Bronchopulmonary DysplasiaMuc1 , Serpine1
Burkitt LymphomaBbc3
BurnsBax , Casp3 , Ccnd1 , Gsk3b , Igf1 , Igfbp3 , Prkcd
CalcinosisCasp3
CamptocormiaRrm2b
CarcinogenesisAbl1 , Cdkn2a , Gsk3b
CarcinomaBrca1 , Ccnd1 , Cdk4 , Cdkn1a , Pten , Tp53
Carcinoma in SituAkt1 , Ccnb1 , Cdkn2a , Pten , Sfn
Carcinoma, Adenoid CysticAtm , Brca1 , Ccnd1 , Crebbp , Ep300 , Pten , Tp53
Carcinoma, Basal CellTp53
Carcinoma, Ductal, BreastBrca1 , Ccnd3 , Cdkn2a , Csnk1e , Serpinb5 , Zfp420
Carcinoma, EmbryonalCcna2 , Chek2
Carcinoma, EndometrioidAkt1 , Ccne1 , Cdk2 , Chek2 , Daxx , Igfbp3 , Pten
Carcinoma, HepatocellularAkt1 , Atm , Bid , Casp8 , Ccnd1 , Ccne1 , Cdk1 , Cdk4 , Cdkn2a , Crebbp , Ep300 , Kat2b , Mdm2 , Pten , Rrm2 , Sfn , Skp2 , Tp53
Carcinoma, Intraductal, NoninfiltratingCcnd1 , Ccnd2 , Cdkn1a , Tp53
Carcinoma, Islet CellDaxx
Carcinoma, LobularCcnd1 , Ccnd2
Carcinoma, Non-Small-Cell LungAkt1 , Casp8 , Cdkn2a , Kat2a , Mdm2 , Pten , Rassf1 , Tp53
Carcinoma, Pancreatic DuctalCdkn1a , Cdkn2a , Hdac1 , Igf1 , Mdm2 , Muc1 , Tsc2
Carcinoma, Renal CellAkt1 , Apaf1 , Atm , Casp3 , Ccnb1 , Ccnd1 , Ccnd3 , Ccne1 , Cdk2 , Cdk4 , Cdkn2a , Fas , Igfbp3 , Muc1 , Pten , Rassf1 , Skp2 , Tp53 , Tp73 , Tsc2
Carcinoma, Small CellRassf1 , Tp53
Carcinoma, Squamous CellAkt1 , Atm , Ccnd1 , Cdkn1a , Cdkn2a , Crebbp , Ep300 , Fas , Hdac1 , Sfn , Tp53 , Tsc2
Carcinoma, Squamous Cell of Head and NeckAkt1 , Casp8 , Cdkn2a , Crebbp , Ep300 , Pten , Serpine1 , Tp53
Carcinoma, Transitional CellAkt1 , Apaf1 , Casp3 , Ccnd1 , Ccnd2 , Cd82 , Cdk1 , Cdk4 , Cdkn1a , Cdkn2a , Crebbp , Daxx , Ep300 , Fas , Igfbp3 , Pten , Rassf1 , Sfn , Skp2 , Tp53 , Tp73
Cardiac FibrosisSerpine1
CardiomegalyAkt1 , Ccnd2 , Ep300 , Gsk3b , Igf1 , Kat8 , Mapk8 , Pin1 , Prkcd , Pten , Yy1
CardiomyopathiesAkt1 , Ep300 , Fas , Mapk14 , Tp53
Cardiomyopathy, DilatedAtm , Bax , Fas , Igf1
Cardiomyopathy, HypertrophicCasp3 , Igf1 , Rassf1 , Tp53 , Yy1
Cardiomyopathy, RestrictiveMapk14 , Prkcd
Carotid Artery DiseasesIgf1 , Tp53
Carotid Artery InjuriesCcna2 , Igf1 , Serpine1
Carotid AtherosclerosisSirt1
CataractAtm , Fas , Pten , Tp53
Cecal NeoplasmsCcnd1 , Tp53
Cell Transformation, NeoplasticBrca1 , Ccnd1 , Mapk8 , Mdm2 , Muc1 , Tp53
Central Nervous System NeoplasmsTp53
Central Serous ChorioretinopathySerpine1
Cerebellar AtaxiaAtm
Cerebral HemorrhageBax , Casp3 , Casp8
Cerebral InfarctionSerpine1
Ceroid Lipofuscinosis, Neuronal 1, InfantileSirt1
Ceroid Lipofuscinosis, Neuronal, 6Gsk3b
Cervical Intraepithelial NeoplasiaBrca1 , Ccnd1 , Ccne1 , Ccng1 , Cdk4 , Cdkn1a , Cdkn2a , Hdac1 , Igfbp3 , Pou4f1 , Pten , Skp2 , Tp73
Chemotherapy-Induced Febrile NeutropeniaMdm2 , Tp53
Chest TraumaFas
ChloracneCdk6 , Cycs , Gadd45a
CholangiocarcinomaCycs , Mdm2 , Muc1 , Pten , Tp53
CholestasisIgf1 , Mapk14 , Serpine1
Cholestasis, ExtrahepaticSetd7
Cholesteatoma, CongenitalCdkn1a
Cholesteatoma, Middle EarCdkn1a , Tp53
ChorioamnionitisFas
Choroid Plexus CarcinomaTp53
Choroidal Neovascularization, ExperimentalSerpine1
Chromosome 17 DeletionTp53
Chromosome AberrationsCdk6
Chromosome BreakageBrca1
Chromosome DeletionCdkn2a
Chronic Allograft NephropathySerpine1
Chronic Cerebral HypoperfusionMapk14
Chronic Lymphoid LeukemiaTp53
Chronic UveitisFas
Clear-Cell Metastatic Renal Cell CarcinomaEp300 , Kat8
ClonorchiasisFas
Cockayne SyndromeIgf1
Cognition DisordersGsk3b , Mapk14
ColitisIgf1 , Sirt1
Colitis, ExperimentalFas
Colitis, IschemicSerpine1
Colitis, UlcerativeTp53
Colonic NeoplasmsAkt1 , Bax , Brca1 , Ccnd1 , Ccnd2 , Ccne1 , Cdkn1a , Cdkn2a , Chek2 , Ep300 , Fas , Hdac1 , Pten , Serpinb5 , Tp53
Colorectal NeoplasmsAkt1 , Bax , Casp8 , Ccnd1 , Cdkn2a , Chek2 , Crebbp , Ep300 , Igfbp3 , Pten , Rrm2 , Serpinb5 , Tp53
Colorectal Neoplasms, Hereditary NonpolyposisFbxo11
Combined Oxidative Phosphorylation Deficiency 3Rrm2b
Common Bile Duct NeoplasmsMuc1
Congenital Adrenal Hyperplasia due to 21 Hydroxylase DeficiencyIgfbp3
Congenital Disorder of Glycosylation Type 1AIgf1 , Igfbp3
Congenital HypothyroidismIgf1
Congenital Myasthenic Syndrome IbBrca1
Conjunctivitis, AllergicMuc1
Conjunctivitis, BacterialMuc1
Conjunctivitis, ChronicFas
Copper-Overload CirrhosisCasp3
Corneal DiseasesIgf1
Corneal NeovascularizationFas
Coronary Artery DiseaseAkt1 , Serpine1
Coronary DiseaseIgf1 , Igfbp3 , Kat2b
Coronary RestenosisTp53
Coronary StenosisIgf1
Craniofacial AbnormalitiesApaf1 , Csnk1a1 , Ep300 , Pten , Tp53
Crohn DiseaseIgf1
CryptorchidismCasp3
Currarino TriadZmat3
Cystadenocarcinoma, SerousCdkn1a , Tp53
Cystadenoma, MucinousDaxx
Cystadenoma, SerousDaxx
Cystic FibrosisFas , Igf1 , Igfbp3 , Muc1
DeafnessIgf1
Deafness, Autosomal Recessive 9Chek2
DementiaBax
Dementia, Multi-InfarctBax
Dementia, VascularIgf1 , Tp53
Demyelinating DiseasesHdac1 , Igf1 , Sirt1 , Tp53
Depressive DisorderBax , Gsk3b
Dermal FibrosisSerpine1
Dermatitis, Allergic ContactCasp8
Dermatitis, AtopicMapk8
Dermatitis, ContactCasp8
DermatomyositisFas
Developmental DisabilitiesPten
Diabetes ComplicationsMuc1
Diabetes MellitusIgf1 , Pten , Serpine1 , Sirt1
Diabetes Mellitus, ExperimentalAkt1 , Bax , Casp3 , Casp8 , Casp9 , Ccna2 , Ccnb1 , Ccnd3 , Cdkn1a , Ep300 , Fas , Hdac1 , Igf1 , Igfbp3 , Mdm2 , Prkcd , Serpine1 , Sirt1 , Tp53 , Tsc2
Diabetes Mellitus, Type 1Casp3 , Casp8 , Casp9 , Cdk4 , Fas , Hdac1 , Igf1 , Igfbp3 , Yy1
Diabetes Mellitus, Type 2Akt1 , Bax , Casp3 , Casp8 , Casp9 , Ccnd2 , Cdk4 , Ep300 , Fas , Gsk3b , Hdac1 , Igf1 , Igfbp3 , Ppp2ca , Serpine1 , Sirt1
Diabetic AngiopathiesCasp3 , Fas , Serpine1
Diabetic CardiomyopathiesIgf1
Diabetic FootIgf1
Diabetic NephropathiesCasp3 , Ccne1 , Ep300 , Fas , Igf1 , Mapk14 , Pten , Serpine1 , Tp53
Diabetic NeuropathiesCasp3 , Igf1 , Mapk14
Diabetic RetinopathyCasp3 , Casp9 , Ep300 , Igf1 , Serpine1 , Sirt1
Diamond-Blackfan Anemia 7Rpl11
Disease Models, AnimalAkt1 , Fas , Mapk8 , Mapk9 , Serpine1 , Tp53
Disease ProgressionCcne1 , Chek2 , Pten , Ptpa , Yy1
Disseminated Intravascular CoagulationSerpine1
Down SyndromeIgfbp3
Drug-Induced Liver InjuryBax , Casp8 , Fas , Gadd45a , Igf1
Drug-induced NeutropeniaMdm2 , Tp53
Drug-Related Side Effects and Adverse ReactionsIgf1 , Tp53
Dry Eye SyndromesMuc1
DwarfismIgf1 , Igfbp3
Dyskeratosis Congenita, Autosomal RecessiveTp53
Dysplastic Nevus SyndromeCdkn2a
EdemaCasp3 , Casp8 , Casp9
EmphysemaTp53
Encephalomyelitis, Autoimmune, ExperimentalCasp3 , Casp8 , Casp9 , Igf1 , Serpine1 , Sirt1
Endometrial HyperplasiaPten , Skp2
Endometrial NeoplasmsAtm , Ccnb1 , Ccnd1 , Cd82 , Cdk2 , Cdk4 , Cdkn1a , Cdkn2a , Ep300 , Hdac1 , Igfbp3 , Pten , Rassf1 , Rrm2 , Sfn , Skp2 , Tp53 , Tp73
EndometriosisBax , Ccne2 , Hdac1 , Igf1
EndophthalmitisFas
EndotoxemiaBax , Casp3 , Ep300 , Fas , Igf1 , Igfbp3 , Mapk14 , Serpine1
Epidermolysis Bullosa DystrophicaIgfbp3
EpilepsyAkt1 , Sirt1 , Tsc2
Erectile DysfunctionAkt1 , Bax , Casp3 , Ccnd1 , Ccnd2 , Igfbp3 , Sirt1
Esophageal NeoplasmsAbl1 , Bax , Bbc3 , Casp8 , Ccnd1 , Cdkn1a , Cdkn2a , Ep300 , Fas , Rprm , Sfn , Tp53
Esophageal Squamous Cell CarcinomaCcnd1 , Cdkn1a , Cdkn2a , Crebbp , Ep300 , Kat2b , Sfn , Tp53
Experimental Autoimmune Encephalomyelitis, Chronic RelapsingSerpine1
Eye AbnormalitiesApaf1
Failure to ThriveAbl1
Familial Mediterranean FeverIgf1 , Serpine1
Familial Primary Pulmonary HypertensionHdac1
Fanconi AnemiaBrca1
Fatty LiverCycs , Mapk8 , Prkcd , Pten , Serpine1 , Sirt1
Fatty Liver, AlcoholicSerpine1
Female Urogenital DiseasesIgf1
Fetal Alcohol Spectrum DisordersIgf1 , Pten
Fetal Growth RetardationBax , Casp3 , Fas , Hdac1 , Igf1 , Igfbp3 , Mdm2 , Muc1 , Serpine1
Fetal MacrosomiaIgf1 , Igfbp3
FeverSerpine1
Fibromatosis, AggressiveSerpine1
FibrosarcomaSerpine1
FibrosisAkt1 , Atm , Ccnd2 , Sirt1
Fibrous Dysplasia, PolyostoticIgfbp3
Focal Cortical Dysplasia of TaylorTsc2
Folic Acid DeficiencyIgf1
Fuchs' Endothelial DystrophyCdkn1a
GABRIELE-DE VRIES SYNDROMEYy1
Gallbladder NeoplasmsCdk1 , Muc1 , Tp53
Gastrointestinal HemorrhageBax
Gastrointestinal NeoplasmsPten
Genetic Diseases, InbornAtm , Crebbp , Hdac1 , Pten
Genomic InstabilityCcnd1 , Sirt1
GerminomaCcnd2 , Cdkn2a
GlaucomaBax , Ccnd2 , Cdkn2a , Crebbp , Fas , Serpine1
Glaucoma, Primary Open AngleCdkn1a , Tp53
GlioblastomaAkt1 , Cdk6 , Cdkn2a , Crebbp , Mdm4 , Pten , Tp53
GliomaCdkn2a , Fas , Igf1 , Igfbp3 , Ppm1d , Pten , Rassf1 , Serpine1 , Tp53
GliosisCd82
GlomerulonephritisBax , Ep300 , Fas , Serpine1
Glomerulonephritis, MembranoproliferativeCdk2 , Ep300
GlomerulosclerosisSerpine1
Glomerulosclerosis, Focal SegmentalSerpine1
Glucose IntoleranceSirt1
Graft vs Host DiseaseFas , Serpine1 , Tp53
Granulomatosis with PolyangiitisIgf1
Granulosa Cell TumorCcnd2 , Cdkn2a
Graves DiseaseFas , Igf1 , Serpine1 , Tp53
Graves OphthalmopathyIgf1 , Serpine1
Growth DisordersIgf1
Growth Hormone-Secreting Pituitary AdenomaCdkn1a
HamartomaTsc2
Hamartoma Syndrome, MultipleAkt1 , Pten
Hashimoto DiseaseFas
Head and Neck NeoplasmsTp53
Head Injuries, ClosedIgf1 , Igfbp3
Hearing Loss, Cisplatin-InducedGsk3b
Hearing Loss, Noise-InducedCdkn1a , Igf1
Hearing Loss, SuddenIgf1 , Serpine1
Heart ArrestAkt1 , Ep300
Heart Defects, CongenitalAbl1
Heart DiseasesBax , Casp9 , Ep300 , Hdac1 , Mapk14 , Muc1 , Ppp2ca , Sirt1
Heart FailureBax , Ccna2 , Chek2 , Fas , Gsk3b , Igf1 , Ppp2ca , Serpine1 , Sirt1 , Tp53 , Yy1
Heart Valve DiseasesCasp3
Heavy Metal ToxicityDaxx
HemangiomaPten , Tsc2
Hemangioma, Cavernous, Central Nervous SystemPten
HemangiosarcomaCcnd1 , Tp53
Hematologic DiseasesFas , Serpine1
Hematologic NeoplasmsMuc1
HemorrhageSerpine1
Hepatitis BKat2a
Hepatitis, AcuteTsc2
Hepatitis, ChronicCasp3
HepatoblastomaTp53
HepatomegalyPten
Hereditary Breast and Ovarian Cancer SyndromeAtm , Brca1 , Chek2
Hernia, DiaphragmaticIgf1
Hernias, Diaphragmatic, CongenitalEp300 , Igf1 , Igfbp3
Heroin DependenceFas
Hirschsprung DiseaseTsc2
Hirschsprung Disease 1Crebbp , Tsc2
HirsutismEp300
HIV InfectionsBax , Cdkn1a , Fas , Gadd45a , Mdm2 , Sirt1 , Yy1
Huntington DiseaseBax , Fas , Hdac1 , Igf1 , Sirt1
Hyaline Membrane DiseaseSerpine1
HyperalgesiaEp300 , Igf1 , Mapk8 , Mapk9
HypercholesterolemiaAtm
Hypercholesterolemia, FamilialSerpine1
HyperglycemiaCasp8
HyperinsulinismPrkcd , Pten
Hyperlipidemia, Familial CombinedSerpine1
HyperoxiaCdk4 , Cdkn1a , Fas , Igf1
HyperparathyroidismCcnd1
Hyperparathyroidism, SecondaryPin1
HyperphagiaIgf1
HyperplasiaAkt1 , Bax , Brca1 , Ccnb1 , Ccnd1 , Cdkn1a , Cdkn2a
HypersplenismFas
HypertensionAkt1 , Bax , Brca1 , Casp3 , Ccne1 , Cd82 , Cdkn2a , Ep300 , Gsk3b , Igf1 , Mapk8 , Pin1 , Prkcd , Pten , Serpine1 , Tp53
Hypertension, PortalPrkcd , Pten
Hypertension, PulmonaryCdkn1a , Hdac1 , Serpine1 , Tp53
Hypertension, RenalCdkn1a
HyperthyroidismSerpine1
HypertrophyPten , Sirt1
Hypertrophy, Left VentricularPrkcd , Pten , Sirt1
Hypertrophy, Right VentricularAkt1 , Hdac1 , Igf1 , Prkcd
HypogonadismTsc2
HypothermiaFas , Mdm2
HypothyroidismIgf1
HypovolemiaCdkn1a
Hypoxia, BrainEp300
Hypoxia-Ischemia, BrainBax , Casp3 , Daxx , Fas , Igf1 , Igfbp3 , Serpine1
IchthyosisIgfbp3 , Mdm2
Idiopathic Hypogonadotropic HypogonadismTsc2
Idiopathic Pulmonary FibrosisFas , Muc1
Immunologic Deficiency SyndromesCasp8
Infarction, Middle Cerebral ArteryBax , Casp3 , Igf1 , Serpine1 , Sirt1
Infectious MononucleosisFas
InfertilityAtm
Infertility, FemaleTp53 , Tsc2
Infertility, MaleBax , Fas , Mdm2 , Tp53
InflammationAkt1 , Tsc2
Inflammatory Bowel Disease 11Casp3 , Cdkn1a
Inflammatory Bowel DiseasesIgfbp3 , Rassf1
Insulin ResistanceAtm , Igfbp3 , Prkcd , Pten , Serpine1 , Sirt1
Insulin-Like Growth Factor I DeficiencyIgf1
INTELLECTUAL DEVELOPMENTAL DISORDER WITH GASTROINTESTINAL DIFFICULTIES AND HIGH PAIN THRESHOLDPpm1d
Intellectual DisabilityCcna2 , Ep300 , Pten , Tsc2 , Yy1
Intermittent ClaudicationBax , Bbc3 , Casp3 , Mdm2
Intervertebral Disc DisplacementAkt1 , Igf1
Intestinal DiseasesBax , Casp3
Intestinal NeoplasmsBax , Cdkn1a , Prkcd
Intestinal PolypsCcnd1 , Serpine1
Intestinal Reperfusion InjurySerpine1
Intimal HyperplasiaCdk2 , Mdm2
IschemiaBax , Cycs , Mapk9 , Tp53
Ischemic Attack, TransientBax , Bbc3 , Casp3 , Casp9 , Cdkn2a , Cycs , Daxx , Ep300 , Fas , Igf1 , Mdm2 , Pten , Serpine1
Kashin-Beck DiseaseBax , Fas
KeloidSerpinb5 , Sfn
KeratosisTp53
Kidney DiseasesCdkn1a , Igf1 , Rrm2b
Kidney Failure, ChronicIgf1 , Serpine1
Kidney NeoplasmsAkt1 , Ccnd1 , Cdkn2a , Chek2 , Rassf1 , Tsc2
Kidney Reperfusion InjuryAtm , Bax , Casp3 , Daxx , Ep300 , Muc1 , Sirt1
Language Development DisordersPten
Laron SyndromeIgf1
Laryngeal NeoplasmsCdkn1a
Lead Poisoning, Nervous SystemEp300
LeiomyomaBax , Ccng1 , Pten , Tsc2
LeiomyosarcomaCdkn2a , Chek2
LEOPARD SyndromePpp1r13l , Pten
LeukemiaAtm , Ccnd1 , Cdkn2a , Daxx , Ppp1r13l , Pten , Tp53
Leukemia, ExperimentalCdkn2a
Leukemia, Lymphocytic, Chronic, B-CellAtm , Fas , Pmaip1 , Tp53
Leukemia, Megakaryoblastic, AcutePten , Tp53
Leukemia, Megakaryoblastic, of Down SyndromeTp53
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveAbl1 , Cdkn2a , Fas , Mapk14
Leukemia, MyeloidIgfbp3
Leukemia, Myeloid, AcuteAbl1 , Ccnd1 , Ccnd2 , Cdk6 , Cdkn2a , Crebbp , Fas , Mdm2 , Pou4f1 , Tp53 , Tsc2
Leukemia, Myeloid, Chronic-PhaseAbl1
Leukemia, Prolymphocytic, T-CellAtm
Leukemia, Promyelocytic, AcuteAkt1
Leukemia, T-CellCdkn2a
Leukemia-Lymphoma, Adult T-CellCsnk1a1 , Fas , Tp53 , Tp73
Leukocyte Adhesion Deficiency Type 1Tsc2
Leukodystrophy, Hypomyelinating, with Hypodontia and Hypogonadotropic HypogonadismTp53
Leukoplakia, OralCdkn1a , Tp53
Leydig Cell TumorCdk4 , Prmt5
Li-Fraumeni SyndromeChek2 , Tp53
Li-Fraumeni Syndrome 2Chek2 , Tp53
Li-Fraumeni-Like SyndromeTp53
Lichen Planus, OralCdkn1a , Tp53
Lip NeoplasmsCdkn1a , Tp53
LipomaPten
LipomatosisPten
LiposarcomaCdk4
Lipoyltransferase 1 DeficiencyTp53
Liver Cirrhosis, BiliaryCdkn1a
Liver Cirrhosis, ExperimentalApaf1 , Ccna2 , Ccnb2 , Ccng1 , Cdk1 , Cdk2 , Cdk4 , Cdkn1a , Fas , Igf1 , Igfbp3 , Prkcd , Sirt1
Liver DiseasesMdm2
Liver Diseases, AlcoholicNedd8
Liver Diseases, ParasiticTp53
Liver Failure, AcuteAtm , Fas , Mapk8
Liver InjurySirt1
Liver NeoplasmsAbl1 , Akt1 , Casp8 , Ccnd1 , Cdkn1a , Cdkn2a , Crebbp , Mapk14 , Serpine1 , Tp53
Liver Neoplasms, ExperimentalCcnb1 , Ccnd1 , Cdkn1a , Ppp2ca , Tp53
Liver Reperfusion InjuryBax , Casp8 , Fas , Mapk8 , Muc1 , Serpine1 , Sirt1
Long QT SyndromePten
Low Tension GlaucomaTp53
Lung DiseasesMuc1 , Serpine1
Lung Diseases, InterstitialMuc1 , Serpine1
Lung InjurySirt1
Lung NeoplasmsAkt1 , Casp8 , Ccnd1 , Ccng1 , Cdkn1a , Cdkn2a , Chek2 , Fas , Mapk14 , Muc1 , Pten , Rassf1 , Tp53 , Tp73
Lung Reperfusion InjuryBax , Casp3 , Serpine1
Lupus Erythematosus, SystemicFas
LymphangioleiomyomatosisTsc2
Lymphatic MetastasisCcne1 , Cdkn1a , Fas , Muc1 , Pten , Sfn , Skp2 , Tp53 , Tsc2
Lymphoblastic Leukemia, Acute, with Lymphomatous FeaturesAbl1
LymphomaAtm , Ccnb1 , Cdkn2a , Pten , Rpl11 , Tp53
Lymphoma, B-CellAtm , Kat5
Lymphoma, B-Cell, Marginal ZoneTp53
Lymphoma, Extranodal NK-T-CellFas
Lymphoma, FollicularCrebbp
Lymphoma, Large B-Cell, DiffuseCdk1 , Cdkn2a , Fas , Skp2
Lymphoma, Mantle-CellAtm , Ccnd1 , Gsk3b
Lymphoma, Non-HodgkinCcnd1 , Chek2 , Tp53
Lymphoma, T-CellAkt1 , Cdkn1a , Ep300 , Tp53
Lymphoma, T-Cell, CutaneousAtm , Bax , Cdkn2a , Fas , Tp53
Lymphoma, T-Cell, PeripheralAtm
Lymphoproliferative DisordersFas
Macrocephaly Autism SyndromePten
Macular DegenerationBax , Cdkn1a , Fas , Serpine1 , Sirt1
Malaria, FalciparumFas
Malformations of Cortical Development, Group IIPten
MalocclusionIgf1 , Igfbp3
Mammary Neoplasms, AnimalBrca1 , Ccnd1 , Cdk4 , Cdkn1a , Rassf1
Mammary Neoplasms, ExperimentalAkt1 , Apaf1 , Bax , Brca1 , Casp3 , Casp8 , Casp9 , Ccna2 , Ccnb1 , Ccnd1 , Ccnd3 , Ccne1 , Cdk2 , Cdk4 , Cdk6 , Cdkn2a , Fas , Igf1 , Muc1 , Pin1 , Pten , Tp53
Marijuana AbuseAkt1
Maxillary Sinus NeoplasmsCdkn1a
MeaslesMuc1
Medullary Cystic Kidney Disease 1Muc1
MedulloblastomaCcne1 , Cdk6 , Crebbp , Ep300 , Rassf1 , Skp2 , Tp53 , Tsc2
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeCcnd2
MegalencephalyPten
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 3Ccnd2
MelanomaAkt1 , Atm , Casp8 , Cdk2 , Cdk4 , Cdkn1a , Cdkn2a , Chek2 , Crebbp , Ep300 , Fas , Mdm2 , Ppp2ca , Pten , Tp53
Melanoma Astrocytoma SyndromeCdkn2a
Melanoma, Cutaneous MalignantCdk4 , Cdkn2a
Melanoma, Cutaneous Malignant, Susceptibility To, 1Cdkn2a , Pten
Melanoma, Cutaneous Malignant, Susceptibility To, 2Cdkn2a
Melanoma, Cutaneous Malignant, Susceptibility To, 3Cdk4
Melanoma-Pancreatic Cancer SyndromeCdkn2a
Memory DisordersAbl1
Meningeal NeoplasmsAkt1
MeningiomaAkt1 , Pten
Meningioma, FamilialPten
MesotheliomaCdkn2a , Muc1 , Rassf1 , Tp53
Mesothelioma, MalignantCcne2 , Cdk6 , Cdkn1a , Cdkn2a , Muc1 , Tp53
Metabolic Syndrome XAtm , Chek2 , Serpine1 , Sirt1
Methylmalonic AcidemiaCycs
MicrocephalyEp300 , Igf1
MICROCEPHALY AND CHORIORETINOPATHY, AUTOSOMAL RECESSIVE, 2Cdk6
Microcephaly, Primary Autosomal Recessive, 5Cdkn2a
MicrognathismEp300
Micronuclei, Chromosome-DefectiveCdkn2a , Rassf1
Microsatellite InstabilityBax
Mitochondrial MyopathiesRrm2b
Mitochondrial Neurogastrointestinal Encephalopathy SyndromeRrm2b
Mixed Connective Tissue DiseaseFas
Mixed Tumor, MullerianCdkn2a , Pten , Tp53
Mood DisordersAkt1
Morphine DependenceBax
Motor Skills DisordersPten
Mouth DiseasesBrca1
Mouth NeoplasmsCdkn2a , Pten , Sfn , Tp53 , Tsc2
Moyamoya DiseaseFas
Multiple MyelomaCcnd1 , Ccnd2 , Ccnd3 , Cdk4 , Cdkn2a , Muc1 , Tp53
Multiple Organ FailureSerpine1
Multiple SclerosisFas , Hdac1
Multiple Sclerosis, Chronic ProgressiveIgfbp3
Multiple Sclerosis, Relapsing-RemittingFas , Serpine1
Multiple System AtrophyFas
Multiple TraumaSerpine1
Multisystemic Smooth Muscle Dysfunction SyndromeFas
Muscle HypotoniaEp300 , Rrm2b
Muscular AtrophyAkt1 , Apaf1 , Gsk3b , Igf1 , Serpine1
Muscular DiseasesPrkcd
Muscular DystrophiesPten
Muscular Dystrophy Congenital, Merosin NegativeBrca1
Muscular Dystrophy, FacioscapulohumeralCdkn1a
Muscular Dystrophy, Limb-Girdle, Type 2AChek2 , Tp53
Muscular Dystrophy, Limb-Girdle, Type 2BChek2
Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 11Brca1
Musculoskeletal AbnormalitiesAbl1
Myasthenia GravisFas
Myasthenic Syndrome, Congenital, Type IdChek2
Mycoplasma InfectionsCasp3
Myelodysplastic SyndromesCdkn2a , Fas , Mdm2 , Tp53
Myocardial InfarctionAkt1 , Atm , Bax , Casp3 , Ccna2 , Gsk3b , Igf1 , Serpine1 , Sirt1 , Tp53 , Ybx1
Myocardial IschemiaBax , Ccna2 , Ccnd1 , Ccnd2 , Igf1 , Igfbp3 , Mapk14 , Ppp2ca , Prkcd
Myocardial Reperfusion InjuryAkt1 , Bax , Bid , Casp3 , Casp8 , Casp9 , Fas , Gsk3b , Mapk14 , Mapk8 , Mapk9 , Mdm2 , Prkcd , Pten , Serpine1 , Sirt1 , Tp53
Myocarditis, Autoimmune, ExperimentalSirt1
MyopiaEp300 , Igf1
Myositis, Inclusion BodyCsnk1a1 , Fas
Nasal PolypsFas , Igf1
Nasopharyngeal CarcinomaCcnd1 , Cdkn2a , Pten , Tp53
Nasopharyngeal NeoplasmsCcnd1 , Tp53
NecrosisFas
NeointimaPin1 , Serpine1 , Yy1
Neoplasm InvasivenessCd82 , Cdkn2a , Igf1 , Pten
Neoplasm MetastasisBax , Casp3 , Ccna2 , Ccnd2 , Ccne1 , Cd82 , Cdkn1a , Cdkn2a , Chek1 , Daxx , Fas , Igf1 , Mapk9 , Muc1 , Pten , Serpinb5 , Tp53
NeoplasmsAtm , Brca1 , Cdkn2a , Chek2 , Mdm2 , Pten , Skp2 , Tp53 , Yy1
Neoplasms, ExperimentalAbl1 , Ccnd1 , Cdk4 , Tp53
Neoplasms, Germ Cell and EmbryonalCcnd2 , Ccne1 , Cdk4 , Cdkn2a
Neoplasms, Squamous CellChek2
Neoplastic Syndromes, HereditaryAtm , Brca1 , Cdk4 , Cdkn2a , Chek1 , Chek2 , Ppm1d , Pten , Tp53 , Tsc2
Neovascularization, PathologicSerpine1
NephritisCcnd2 , Fas
Nephritis, InterstitialBax
Nephrosis, LipoidCdkn1a
Nephrosis, Puromycin AminonucleosideFas
Nephrotic SyndromeSerpine1
Nerve DegenerationBax , Casp3 , Igf1 , Sirt1 , Tsc2 , Zmat3
Nerve Sheath NeoplasmsCdkn2a , Pten , Tp53
Nervous System DiseasesCasp3 , Casp9 , Serpine1 , Tp53
Nervous System MalformationsTp73
Neural Tube DefectsKat2a
NeurilemmomaCdkn2a , Serpine1
NeuroblastomaCdkn2a , Chek2 , Rassf1 , Tp53 , Tp73
Neurodegenerative DiseasesSirt1
Neurodevelopmental DisordersPpm1d , Pten
Neuroendocrine TumorsDaxx
Neurologic ManifestationsTp73
Neuroma, AcousticCdkn1a , Igf1 , Igfbp3
Neuropathy, PainfulEp300
Neurotoxicity SyndromesCasp3 , Prkcd
Niemann-Pick Disease, Type CAbl1
Niemann-Pick DiseasesAbl1
Non-alcoholic Fatty Liver DiseaseFas , Igf1 , Serpine1 , Sirt1
Noonan SyndromeIgf1 , Serpine1
Nose NeoplasmsTp53
ObesityAkt1 , Cdk4 , Cdkn2a , Cycs , Ep300 , Igfbp3 , Prkcd , Serpine1 , Sirt1
Ocular HypertensionCdkn1a , Fas
Odontogenic MyxomaTp53
Ophthalmoplegia, Chronic Progressive ExternalRrm2b
Optic Atrophy, Hereditary, LeberTp53
Optic Nerve InjuriesBax , Cdk2 , Ep300
Oral Squamous Cell CarcinomaCdkn1a , Serpine1
Oral Submucous FibrosisTp53
Ornithine Carbamoyltransferase Deficiency DiseaseIgfbp3
Oropharyngeal NeoplasmsTp53
OsteoarthritisBax , Cdkn2a , Igf1 , Igfbp3
Osteoarthritis, KneeBax , Igf1
Osteoarthritis, Temporomandibular JointFas
OsteochondrodysplasiasPten
OsteophyteIgf1
OsteoporosisAbl1 , Atm , Bax , Igf1 , Igfbp3 , Mapk14 , Sirt1
Osteoporosis, PostmenopausalIgf1
Osteoporotic FracturesIgf1
OsteosarcomaAkt1 , Ccnb3 , Chek2 , Tp53
Otitis MediaMuc1
Ovarian Epithelial CancerDaxx , Tp53
Ovarian NeoplasmsAkt1 , Brca1 , Ccnb1 , Ccnd1 , Ccnd2 , Ccnd3 , Ccne1 , Cd82 , Cdk2 , Cdk4 , Cdkn1a , Cdkn2a , Chek2 , Fas , Gadd45a , Hdac1 , Igfbp3 , Pten , Rassf1 , Sfn , Skp2 , Tp53 , Tp73
Oxygen-Induced RetinopathyFas , Igf1 , Mapk8 , Serpine1
PainAkt1
Pancreatic AdenocarcinomaCdkn2a , Tp53
Pancreatic CarcinomaCdkn1a , Cdkn2a , Tp53
Pancreatic Intraepithelial NeoplasiaHdac1
Pancreatic Islet Cell TumorsDaxx
Pancreatic NeoplasmsApaf1 , Atm , Bid , Brca1 , Casp8 , Cdkn2a , Chek1 , Cycs , Daxx , Gadd45a , Igf1 , Muc1 , Pten , Rrm2 , Tp53 , Tsc2
PancreatitisCasp3 , Mdm2
Pancreatitis, Acute NecrotizingCasp3 , Serpine1
Pancreatitis, Experimental, Acute Cdkn1a
Papillary Renal Cell Carcinoma, SporadicCdkn2a , Tp53
PapillomaCcnd1 , Cdkn1a
Papilloma, Choroid PlexusTp53
Papilloma, InvertedCdkn1a
Papillomavirus InfectionsCasp8 , Cdkn2a
ParalysisSirt1
Paranasal Sinus NeoplasmsTp53
ParaplegiaAkt1
Parkinson DiseaseAbl1 , Akt1 , Atm , Fas , Gsk3b , Nedd8 , Ppp2ca
Parkinsonian DisordersPrkcd
PEHO SyndromeIgf1
Pena Shokeir Syndrome, Type 1Chek2
Penile NeoplasmsCcnd1 , Tp53
Peripheral Arterial DiseaseSerpine1
Peripheral Nervous System DiseasesCasp9 , Cdkn2a , Igf1
Peripheral Nervous System NeoplasmsPten
Peripheral Vascular DiseasesFas
Peritoneal AdhesionsSerpine1
Peritoneal FibrosisSerpine1
Peritoneal NeoplasmsMuc1
PeritonitisGsk3b
Persistent Hyperplastic Primary VitreousCdkn2a
Phyllodes TumorCdkn1a , Tp53
Pituitary NeoplasmsCdkn1a , Igf1
Placental InsufficiencySerpine1
Plaque, AtheroscleroticIgf1
PlasmacytomaCdkn2a
Plasminogen Activator Inhibitor-1 DeficiencySerpine1
Platelet Glycoprotein IV DeficiencySerpine1
Pleomorphic Xanthoastrocytoma Cdk6 , Cycs , Igfbp3 , Serpine1 , Znhit1
PleurisySerpine1
PneumoconiosisMdm4
PneumoniaMuc1 , Serpine1 , Sirt1
Pneumonia, BacterialSerpine1
Pneumonia, PneumococcalSirt1
Pneumonia, PneumocystisMuc1
PoisoningCdkn2a , Gsk3b
Polycystic Kidney, Autosomal DominantCdkn1a
Polycystic Kidney, Autosomal RecessiveAkt1
Polycystic Ovary SyndromeBax , Ccnb1 , Ccne2 , Igf1 , Rrm2 , Serpine1
PolycythemiaSerpine1
PolydactylyPten
PolyneuropathiesSerpine1
PolyploidyChek1 , Tp53
Pre-EclampsiaFas , Serpine1
Precancerous ConditionsAbl1 , Akt1 , Atm , Ccnd1 , Cdkn2a , Mapk8 , Mapk9 , Mdm2 , Ppm1d , Tp53 , Tsc2
Precursor B-Cell Lymphoblastic Leukemia-LymphomaAbl1 , Ccnd1 , Cdkn2a , Tp53
Precursor Cell Lymphoblastic Leukemia-LymphomaAbl1 , Casp8 , Ccnd1 , Cdk6 , Cdkn2a , Crebbp , Fas , Hdac1 , Tp53
Precursor T-Cell Lymphoblastic Leukemia-LymphomaBax , Cdkn2a , Rpl11
Pregnancy ComplicationsSerpine1
Pregnancy Complications, CardiovascularFas
Prenatal Exposure Delayed EffectsAtm
PriapismMdm2
PRIMARY AUTOSOMAL RECESSIVE MICROCEPHALY 12Cdk6
Primary MyelofibrosisTp53
ProgeriaIgf1
Progressive External Ophthalmoplegia with Mitochondrial Dna Deletions, Autosomal Dominant, 5Rrm2b
Proliferative Diabetic RetinopathySerpine1
Prostate Cancer, FamilialChek2
Prostate Cancer, SomaticChek2 , Pten
Prostatic HyperplasiaCcnb1 , Cdk4 , Pten , Tp73
Prostatic Intraepithelial NeoplasiaAtm , Ccnd1 , Ccne1 , Hdac1 , Igf1 , Pten
Prostatic NeoplasmsAkt1 , Atm , Bax , Brca1 , Casp3 , Casp9 , Ccna2 , Ccnb1 , Ccnd1 , Ccnd2 , Ccnd3 , Ccne1 , Cd82 , Cdk1 , Cdk2 , Cdk4 , Cdkn1a , Cdkn2a , Chek2 , Crebbp , Daxx , Ei24 , Ep300 , Fas , Gadd45a , Gsk3b , Hdac1 , Igf1 , Igfbp3 , Kat5 , Mdm2 , Muc1 , Ppp2ca , Pten , Rassf1 , Serpine1 , Sesn3 , Sirt1 , Skp2 , Tp53 , Tp73 , Trim28 , Zmat3
Protein C Deficiency, AcquiredSerpine1
ProteinuriaFas
Proteus SyndromeAkt1 , Pten
PsoriasisCdkn1a , Igf1 , Tp53
Psychoses, Substance-InducedAkt1
Pten Hamartoma Tumor Syndrome with Granular Cell TumorPten
PterygiumTp53
Puberty, PrecociousIgf1
Pulmonary Disease, Chronic ObstructiveMapk8 , Muc1 , Serpine1 , Tp53
Pulmonary FibrosisIgf1 , Igfbp3 , Serpine1
Purpura, Schoenlein-HenochIgf1
Purpura, Thrombocytopenic, IdiopathicFas
PycnodysostosisIgf1
Radiation Injuries, ExperimentalFas
Radiation nephropathySerpine1
RecurrenceCcne1
Renal FibrosisSerpine1
Reperfusion InjuryAkt1 , Apaf1 , Bax , Bid , Casp3 , Casp8 , Casp9 , Ccnb1 , Ccnd1 , Ccne1 , Ccng1 , Cdkn1a , Ep300 , Fas , Igf1 , Mapk8 , Mapk9 , Muc1 , Pten , Tp53
Respiratory Distress Syndrome, AdultMuc1 , Serpine1
Respiratory HypersensitivitySerpine1
Retina Reperfusion InjuryBax
Retinal DegenerationBax
Retinal DetachmentApaf1 , Casp3 , Casp9 , Fas
Retinal DiseasesCasp3 , Sirt1
Retinal Vein OcclusionSerpine1
Retinitis PigmentosaPten
RetinoblastomaFas
Retinopathy of PrematurityIgf1 , Igfbp3 , Serpine1
RhabdomyosarcomaBrca1 , Cdkn2a , Tp53
Rhabdomyosarcoma, AlveolarTp73
Rheumatic Heart DiseaseIgf1
RhinitisSerpine1
Rhinitis, AllergicSerpine1
RhinosinusitisIgf1 , Serpine1
Rubinstein-Taybi SyndromeCrebbp , Ep300
Salivary Gland DiseasesCasp3
Salivary Gland NeoplasmsCcnd1 , Cdkn1a
SarcoidosisCdkn1a
Sarcoidosis, PulmonaryMuc1
SarcomaMdm2 , Tp53
Sarcoma Family Syndrome of Li and FraumeniTp53
Sarcoma, KaposiTp53
SarcopeniaBax , Cdkn1a , Igf1
SchistosomiasisRassf1
SchizophreniaAkt1 , Gsk3b , Tp53
Schizophrenia, ChildhoodPpp1r13b
Sciatic NeuropathyRchy1 , Serpine1
Scleroderma, LimitedFas , Serpine1
Scleroderma, LocalizedCdkn1a
Scleroderma, SystemicIgfbp3 , Muc1 , Serpine1 , Sirt1
ScoliosisCrebbp
Sebaceous Gland NeoplasmsCdkn1a
SeizuresApaf1 , Ccnb1 , Ccnd1 , Fas , Prkcd , Pten , Tsc2
SeminomaCcnd2 , Chek2 , Fas , Prmt5
Senile CataractSirt1
SepsisCasp3 , Casp8 , Cdkn1a , Ep300 , Fas , Gsk3b , Serpine1
Severe Combined Immunodeficiency due to Adenosine Deaminase DeficiencyBrca1
Sezary SyndromeCdkn2a , Crebbp , Pten , Tp53
Shock, HemorrhagicSirt1
Shock, SepticSerpine1
Sinonasal NeoplasmsCdkn1a
Sjogren's SyndromeFas
Skin AbnormalitiesApaf1
Skin DiseasesGadd45b , Pten
Skin NeoplasmsAkt1 , Casp8 , Cdkn1a , Igf1 , Tp53
Skull FracturesIgf1
Sleep Apnea SyndromesSerpine1
Sleep Apnea, ObstructiveMuc1 , Serpine1
Small Cell Lung CarcinomaAkt1 , Crebbp , Ep300 , Pten , Tp53
Smith-Magenis SyndromeBrca1 , Csnk1d , Kat2a , Ppm1d , Rpl23
Spasms, InfantileTsc2
Spastic Paraplegia 7, Autosomal RecessiveAtm
Spastic Paraplegia Type 7Atm
Spinal Cord CompressionFas
Spinal Cord InjuriesAkt1 , Atm , Casp3 , Ccnd3 , Ccne1 , Cdk1 , Fas , Mdm2 , Tp53
Spinal FracturesIgfbp3
Spinocerebellar AtaxiasKat2a
Spondylitis, AnkylosingIgfbp3
Squamous Cell Carcinoma of the LungAkt1 , Cdkn2a , Crebbp , Ep300 , Pten , Tp53
Squamous Cell Carcinoma of the TongueCdkn1a , Tp53
Stargardt Disease 1Chek2
Status EpilepticusAtm , Bax , Casp3 , Casp8 , Ccnd1 , Gsk3b
Stevens-Johnson SyndromeEp300
Stomach DiseasesPten
Stomach NeoplasmsAtm , Bid , Casp8 , Ccnd1 , Cdk4 , Cdkn1a , Cdkn2a , Chek2 , Gadd45a , Igfbp3 , Mapk8 , Muc1 , Ptpa , Serpine1 , Tp53
Stress Disorders, Post-TraumaticBax , Mdm2
StrokeAkt1 , Casp3 , Hdac1 , Igf1 , Mapk8 , Prkcd , Serpine1
Subarachnoid HemorrhageCasp3
Substance-Related DisordersPmaip1 , Pten
Taste DisordersFas
TauopathiesGsk3b , Hdac1
TeratomaBax
Testicular InjuryFas
Testicular NeoplasmsCcnd2
ThinnessIgf1
ThrombocytopeniaCycs
Thrombocytopenia 4Cycs
ThrombosisSerpine1 , Sirt1
Thumb DeformityCrebbp
ThymomaCdkn2a , Tp53
Thymus NeoplasmsTp53
Thyroid Cancer, FollicularPten
Thyroid Carcinoma, AnaplasticTp53
Thyroid NeoplasmsCcnd1 , Cdk1 , Cdkn1a , Pten , Tp53
ThyroiditisBax
Tongue NeoplasmsCdkn1a , Cdkn2a , Igf1 , Tp53
TonsillitisIgfbp3
ToxoplasmosisBax
Translocation, GeneticCdkn2a
Transplant RejectionPin1
Trigeminal Nerve InjuriesTp53
Trigeminal NeuralgiaMapk8 , Mapk9
Triple Negative Breast NeoplasmsChek2
TrisomyCdkn2a
Tuberous SclerosisTsc2
Tuberous Sclerosis 1Tsc2
Tuberous Sclerosis 2Tsc2
Tubulointerstitial Nephritis and UveitisMuc1
Tumor Predisposition SyndromeAtm , Brca1 , Cdk4 , Cdkn2a , Chek2 , Pten , Tp53 , Tsc2
Turner SyndromeIgf1 , Igfbp3
Ureteral ObstructionAbl1 , Akt1 , Serpine1
Urinary Bladder DiseasesRassf1
Urinary Bladder NeoplasmsAkt1 , Atm , Bax , Brca1 , Casp3 , Casp9 , Ccnd3 , Ccne1 , Cd82 , Cdk1 , Cdk4 , Cdkn1a , Cdkn2a , Chek2 , Crebbp , Ep300 , Fas , Igf1 , Igfbp3 , Muc1 , Pten , Rassf1 , Rrm2 , Serpine1 , Sfn , Tp53 , Tp73 , Usp7
Urogenital NeoplasmsCdkn2a , Tp53
Urologic NeoplasmsCcnd1 , Tp53
Uterine Cervical NeoplasmsAkt1 , Bax , Brca1 , Casp3 , Casp8 , Ccnb1 , Ccnd1 , Ccnd3 , Ccne1 , Ccng1 , Cd82 , Cdk1 , Cdk2 , Cdk4 , Cdkn1a , Cdkn2a , Chek2 , Crebbp , Ep300 , Hdac1 , Igfbp3 , Pou4f1 , Pten , Rassf1 , Skp2 , Tp53 , Tp73 , Yy1
Uterine NeoplasmsPten , Tp53
Uveal MelanomaIgf1 , Serpine1
Uveitis, Autoimmune, ExperimentalFas
VACTERL/VATER Association with HydrocephalusPten
VaricoceleCasp9 , Fas
Vascular DepressionSerpine1
Vascular RemodelingSerpine1
Venous ThromboembolismSerpine1
Venous ThrombosisSerpine1
Ventilator-Induced Lung InjuryAkt1 , Gadd45a , Serpine1
Ventricular Dysfunction, LeftAtm , Fas
von Hippel-Lindau DiseaseCcnd1
Vulvar Lichen SclerosusCdkn2a , Tp53
Vulvar NeoplasmsCdkn2a , Chek2 , Sfn , Tp53 , Tp73
Wallerian DegenerationSirt1
Wet Macular DegenerationIgf1 , Mapk8
Wilms TumorCcnd2 , Cdk4 , Cdkn2a , Tp73
Wounds and InjuriesIgf1
Wounds, PenetratingSerpine1
Xeroderma PigmentosumTp53
Zinc DeficiencyIgf1
Pathway Annotations Associated with Genes in the p53 signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Ccnd1
adenine phoshoribosyltransferase deficiency pathwayRrm2
adenosine monophosphate deaminase deficiency pathwayRrm2
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayPpp2ca
adenosine signaling pathwayAkt1 , Mapk8
adenylosuccinate lyase deficiency pathwayRrm2
AICA-ribosuria pathwayRrm2
aldosterone signaling pathwayCrebbp , Daxx , Igf1 , Sfn
allograft rejection pathwayFas
altered G1/S transition pathwayCdkn2a
altered insulin-like growth factor signaling pathwayIgf1
altered p53 signaling pathwayMdm2 , Mdm4 , Pin1 , Tp53 , Tp73
altered phosphatidylinositol 3-kinase signaling pathwayPten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Pten
Alzheimer disease pathwayApaf1 , Bid , Casp3 , Casp8 , Casp9 , Cycs , Cyct , Fas , Gsk3b
amyotrophic lateral sclerosis disease pathwayApaf1 , Bax , Bid , Casp3 , Casp9 , Cycs , Cyct , Daxx , Mapk14 , Tp53
androgen signaling pathwayCrebbp , Ep300
apoptotic cell death pathwayAkt1 , Apaf1 , Atm , Bax , Bid , Casp3 , Casp8 , Casp9 , Cycs , Cyct , Fas , Tp53
ataxia telangiectasia-mutated (ATM) signaling pathwayAtm , Brca1 , Kat5 , Ppm1d , Ppp2ca
autoimmune thyroid disease pathwayFas
azathioprine pharmacodynamics pathwayRrm2
B cell receptor signaling pathwayAkt1 , Gsk3b
basal cell carcinoma pathwayGsk3b , Tp53
beta-ureidopropionase deficiency pathwayRrm2 , Rrm2b
bladder cancer pathwayCcnd1 , Cdk4 , Cdkn1a , Cdkn2a , Mdm2 , Rassf1 , Tp53
Bone morphogenetic proteins signaling pathwayGsk3b
c-Jun N-terminal kinases MAPK signaling pathwayMapk8 , Mapk9
calcium/calmodulin dependent kinase 2 signaling pathwayPpp2ca
cardiolipin metabolic pathwayCycs
cardiovascular system disease pathwayIgf1
carnitine biosynthetic pathwaySetd7
cell cycle pathway, mitoticAbl1 , Atm , Ccna2 , Ccnb1 , Ccnb2 , Ccnb3 , Ccnd1 , Ccnd2 , Ccnd3 , Ccne1 , Ccne2 , Cdk1 , Cdk2 , Cdk4 , Cdk6 , Cdkn1a , Cdkn2a , Chek1 , Chek2 , Crebbp , Ep300 , Gadd45a , Gadd45b , Gadd45g , Gsk3b , Hdac1 , Mdm2 , Sfn , Skp2 , Tp53
ceramide signaling pathwayAkt1 , Bax , Bid , Casp8 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Cycs , Igf1 , Mapk8 , Mapk9 , Prkcd , Tp53
CHD family mediated chromatin remodeling pathwayHdac1
chemokine mediated signaling pathwayAkt1 , Gsk3b , Prkcd
chronic myeloid leukemia pathwayAbl1 , Akt1 , Ccnd1 , Cdk4 , Cdk6 , Cdkn1a , Cdkn2a , Hdac1 , Mdm2 , Tp53
cisplatin drug pathwayYbx1
coagulation cascade pathwaySerpine1
colorectal cancer pathwayAkt1 , Bax , Casp3 , Casp9 , Ccnd1 , Cycs , Cyct , Gsk3b , Mapk8 , Mapk9 , Tp53
complement system pathwaySerpine1
cortisol signaling pathwayCrebbp , Ep300
cytokine mediated signaling pathwayFas
dihydropyrimidinase deficiency pathwayRrm2 , Rrm2b
dilated cardiomyopathy pathwayIgf1
dopamine signaling pathwayCsnk1a1 , Ppp2ca
E-cadherin signaling pathwayAkt1 , Ccnd1 , Igf1
eicosanoid signaling pathwayAkt1 , Mapk14 , Prkcd
electron transport chain pathwayCycs
endocytosis pathwayMdm2
endometrial cancer pathwayAkt1 , Casp9 , Ccnd1 , Gsk3b , Pten , Tp53
Endoplasmic Reticulum-associated degradation pathwayBax , Mapk8 , Mapk9 , Ube2d1
endothelin signaling pathwayAkt1 , Mapk14 , Mapk8 , Prkcd
Entamoeba histolyca infection pathwayCasp3
ephrin - ephrin receptor bidirectional signaling axisMapk8
epidermal growth factor/neuregulin signaling pathwayAbl1 , Akt1 , Cdkn1a , Gsk3b , Mapk8 , Mapk9
erythropoietin signaling pathwayMapk14 , Mapk8
estrogen signaling pathwayCrebbp , Ep300
extrinsic apoptotic pathwayCasp3 , Casp8 , Fas
FasL mediated signaling pathwayAkt1 , Bid , Casp3 , Casp8 , Fas , Mapk14 , Mapk8 , Mapk9
Fc epsilon receptor mediated signaling pathwayAkt1 , Mapk14 , Mapk8 , Mapk9 , Prkcd
Fc gamma receptor mediated signaling pathwayAkt1 , Prkcd
fibrinolysis pathwaySerpine1
fibroblast growth factor signaling pathwayAkt1
forkhead class A signaling pathwayAkt1 , Brca1 , Crebbp , Ep300
G1 phase pathwayCcnd1 , Cdk4
G1/S DNA damage checkpoint pathwayCcne1
G1/S transition pathwayCcna2 , Ccnb1 , Ccnd1 , Ccnd2 , Ccnd3 , Ccne1 , Ccne2 , Cdk1 , Cdk2 , Cdk4 , Cdk6 , Cdkn1a , Cdkn2a
G2/M checkpoint pathwayCcnb1 , Cdk1
G2/M DNA damage checkpoint pathwayCcnb1 , Cdk1 , Chek1
G2/M DNA replication checkpoint pathwayCcnb1 , Cdk1
G2/M transition pathwayCcnb1 , Cdk1
gemcitabine pharmacodynamics pathwayRrm2 , Rrm2b
gemcitabine pharmacokinetics pathwayRrm2 , Rrm2b
glioma pathwayAkt1 , Ccnd1 , Cdk4 , Cdk6 , Cdkn1a , Cdkn2a , Igf1 , Mdm2 , Pten , Tp53
glutathione metabolic pathwayRrm2 , Rrm2b
glycogen biosynthetic pathwayGsk3b
glypican signaling pathwayMapk8 , Mapk9
gonadotropin-releasing hormone signaling pathwayMapk14 , Mapk8 , Mapk9 , Prkcd
graft-versus-host disease pathwayFas
Hedgehog signaling pathwayAkt1 , Crebbp , Csnk1a1 , Csnk1d , Csnk1e , Csnk1g1 , Csnk1g2 , Csnk1g3 , Gsk3b , Hdac1 , Prkcd
hepatitis C virus infection pathwayAkt1 , Cdkn1a , Gsk3b , Mapk14 , Mapk8 , Mapk9 , Ppp2ca , Tp53
histone modification pathwayCrebbp , Daxx , Ep300 , Hdac1 , Kat2a , Kat2b , Kat5 , Kat8 , Prmt5 , Setd7 , Sirt1 , Smyd2
homocysteine metabolic pathwayPrmt5
homologous recombination pathway of double-strand break repairAtm , Brca1
Huntington disease pathwayApaf1 , Bax , Bbc3 , Casp3 , Casp8 , Casp9 , Crebbp , Cycs , Cyct , Ep300 , Hdac1 , Tp53
hypertrophic cardiomyopathy pathwayIgf1
hypoxia inducible factor pathwayAkt1 , Crebbp , Ep300 , Serpine1
inflammatory response pathwayMapk8
influenza A virus infection pathwayAkt1 , Casp9 , Crebbp , Cycs , Cyct , Ep300 , Fas , Gsk3b , Mapk14 , Mapk8 , Mapk9
INO80 family mediated chromatin remodeling pathwayKat5 , Yy1 , Znhit1
inositol phosphate metabolic pathwayPten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Gsk3b , Sfn
insulin signaling pathwayAkt1 , Gsk3b , Mapk8 , Mapk9 , Tsc2
insulin-like growth factor signaling pathwayAkt1 , Igf1 , Igfbp3 , Prkcd
interleukin-1 signaling pathwayMapk8
interleukin-12 signaling pathwayGadd45b , Gadd45g , Mapk14
interleukin-2 signaling pathwayCdk2 , Mapk14 , Mapk8 , Mapk9
interleukin-3 signaling pathwayHdac1
interleukin-4 signaling pathwayAkt1 , Mapk14
interleukin-6 signaling pathwayAkt1 , Mapk14 , Prkcd
intrinsic apoptotic pathwayApaf1 , Bax , Bbc3 , Bid , Casp3 , Casp9 , Cycs , Fas , Pmaip1
iron uptake pathwaySteap3
Jak-Stat signaling pathwayAkt1 , Ccnd1 , Ccnd2 , Ccnd3 , Crebbp , Ep300
Kelley-Seegmiller syndrome pathwayRrm2
Leishmania infection pathwayMapk14
Lesch-Nyhan syndrome pathwayRrm2
long term depressionGsk3b , Igf1 , Ppp2ca
long term potentiationCrebbp , Ep300
lysine degradation pathwaySetd7
measles infection pathwayAkt1 , Bbc3 , Ccnd1 , Ccnd2 , Ccnd3 , Ccne1 , Ccne2 , Cdk2 , Cdk4 , Cdk6 , Fas , Gsk3b , Rchy1 , Tp53 , Tp73
melanoma pathwayAkt1 , Ccnd1 , Cdk4 , Cdk6 , Cdkn1a , Cdkn2a , Igf1 , Mdm2 , Pten , Tp53
mercaptopurine pharmacodynamics pathwayRrm2
methionine cycle/metabolic pathwayPrmt5 , Setd7 , Smyd2
mitochondrial neurogastrointestinal encephalopathy syndrome pathwayRrm2 , Rrm2b
mitogen activated protein kinase signaling pathwayAkt1 , Casp3 , Daxx , Fas , Gadd45a , Gadd45b , Gadd45g , Mapk14 , Mapk8 , Mapk9 , Tp53 , Tsc2
molybdenum cofactor deficiency pathwayRrm2
mRNA decay pathwayPpp2ca
mTOR signaling pathwayAkt1 , Ccne1 , Cdk2 , Cycs , Igf1 , Sfn , Tsc2 , Yy1
Mycobacterium tuberculosis infection pathwayAkt1 , Apaf1 , Bax , Bid , Casp3 , Casp8 , Casp9 , Crebbp , Cycs , Cyct , Ep300 , Mapk14 , Mapk8 , Mapk9
myocarditis pathwayAbl1 , Bid , Casp3 , Casp8 , Casp9 , Ccnd1 , Cycs , Cyct
N-cadherin signaling pathwayMapk8
neddylation pathwayNedd8
neurotrophic factor signaling pathwayAbl1 , Akt1 , Bax , Gsk3b , Mapk14 , Mapk8 , Mapk9 , Prkcd , Tp53 , Tp73
NOD-like receptor signaling pathwayCasp8 , Mapk14 , Mapk8 , Mapk9
non-small cell lung cancer pathwayAkt1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Pten , Rassf1 , Tp53
Notch signaling pathwayCcnd1 , Cdkn1a , Crebbp , Ep300 , Hdac1 , Kat2a , Kat2b , Skp2 , Yy1
nuclear factor kappa B signaling pathwayAtm , Mapk14
nuclear factor, erythroid 2 like 2 signaling pathwayBrca1 , Cdkn1a , Crebbp , Gsk3b , Pten
oroticaciduria 1 disease pathwayRrm2 , Rrm2b
oxygen homeostasis pathwaySerpine1
p38 MAPK signaling pathwayAtm , Gadd45a , Gadd45b , Gadd45g , Mapk14 , Ppm1d
p53 signaling pathwayAbl1 , Adgrb1 , Akt1 , Apaf1 , Atm , Bax , Bbc3 , Bid , Brca1 , Casp3 , Casp8 , Casp9 , Ccna2 , Ccnb1 , Ccnb2 , Ccnb3 , Ccnd1 , Ccnd2 , Ccnd3 , Ccne1 , Ccne2 , Ccng1 , Ccng2 , Cd82 , Cdk1 , Cdk2 , Cdk4 , Cdk6 , Cdkn1a , Cdkn2a , Chek1 , Chek2 , Crebbp , Cse1l , Csnk1a1 , Csnk1d , Csnk1e , Csnk1g1 , Csnk1g2 , Csnk1g3 , Cycs , Cyct , Daxx , Dyrk2 , E4f1 , Ei24 , Ep300 , Fas , Fbxo11 , Gadd45a , Gadd45b , Gadd45g , Gsk3b , Gtse1 , Hdac1 , Hipk2 , Igf1 , Igfbp3 , Kat2a , Kat2b , Kat5 , Kat8 , Mapk14 , Mapk8 , Mapk9 , Mdm2 , Mdm4 , Muc1 , Nedd8 , Perp , Pin1 , Pmaip1 , Pou4f1 , Pou4f2 , Ppm1d , Ppp1r13b , Ppp1r13l , Ppp2ca , Prkcd , Prmt5 , Pten , Ptpa , Rassf1 , Rchy1 , Rfwd2 , Rpl11 , Rpl23 , Rpl5l1 , Rprm , Rrm2 , Rrm2b , Serpinb5 , Serpine1 , Sesn1 , Sesn3 , Setd7 , Sfn , Shisa5 , Siah1 , Sirt1 , Skp2 , Smyd2 , Steap3 , Tp53 , Tp53bp2 , Tp73 , Trim28 , Tsc2 , Ttc5 , Ube2d1 , Usp7 , Ybx1 , Yy1 , Zfp385a , Zfp420 , Zmat3 , Znhit1
p53-dependent G1/S DNA damage checkpoint pathwayCcne1 , Tp53
pancreatic cancer pathwayAkt1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Mapk8 , Mapk9 , Pten , Tp53
Parkinson disease pathwayApaf1 , Casp3 , Casp9 , Cycs , Cyct
phosphatidylinositol 3-kinase class I signaling pathwayPten
phosphatidylinositol 3-kinase signaling pathwayPten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Casp9 , Cdkn1a , Gsk3b , Ppp2ca , Pten , Sfn
phosphoinositide metabolic pathwayPten
platelet-derived growth factor signaling pathwayAbl1 , Mapk8 , Mapk9 , Pin1 , Ppp2ca , Prkcd , Pten , Sfn
prion diseases pathwayBax
prostate cancer pathwayAkt1 , Casp9 , Ccnd1 , Ccne1 , Ccne2 , Cdk2 , Cdkn1a , Crebbp , Ep300 , Gsk3b , Igf1 , Mdm2 , Pten , Tp53
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesNedd8
protein kinase C (PKC) signaling pathwayPrkcd
purine metabolic pathwayRrm2 , Rrm2b
purine nucleoside phosphorylase deficiency pathwayRrm2
pyrimidine metabolic pathwayRrm2 , Rrm2b
Ras mediated signaling pathwayTp73
Reelin signaling pathwayAkt1 , Gsk3b , Mapk8
renal cell cancer pathwayAkt1 , Crebbp , Ep300
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8 , Mapk14 , Mapk8 , Mapk9 , Pin1
Rho/Rac/Cdc42 mediated signaling pathwayMapk8
ribosome biogenesis pathwayCsnk1d , Csnk1e , Rpl11 , Rpl23
RNA polymerase I transcription pathwayCrebbp , Sirt1
RNA polymerase II transcription initiation pathwayKat2a , Kat2b
RNA transport pathwayPrmt5
S phase pathwayCcnd1 , Cdk4
Sirtuin mediated pathwaySirt1
small cell lung cancer pathwayAkt1 , Apaf1 , Casp9 , Ccnd1 , Ccne1 , Ccne2 , Cdk2 , Cdk4 , Cdk6 , Cycs , Cyct , Pten , Skp2 , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Mapk14 , Mapk8
syndecan signaling pathwayBax , Casp3 , Mapk8 , Prkcd
T cell receptor signaling pathwayAkt1 , Cdk4 , Gsk3b , Mapk14 , Mapk9
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayPrkcd , Tsc2
thyroid cancer pathwayCcnd1 , Tp53
tioguanine pharmacodynamics pathwayRrm2
titanium dioxide nanoparticle response pathwayBax , Casp3 , Casp8 , Fas , Tp53
Toll-like receptor signaling pathwayAkt1 , Casp8 , Mapk14 , Mapk8 , Mapk9
Toxoplasma gondii infection pathwayAkt1 , Casp3 , Casp8 , Casp9 , Cycs , Cyct , Mapk14 , Mapk8 , Mapk9
Trail mediated signaling pathwayBid , Casp3 , Casp8 , Mapk8
transforming growth factor-beta signaling pathwayTsc2
transforming growth factor-beta Smad dependent signaling pathwayCrebbp , Daxx , Ppp2ca
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Ep300 , Ppp2ca
translation pathwayRpl11 , Rpl23
Trypanosoma brucei infection pathwayFas
Trypanosoma cruzi infection pathwayAkt1 , Casp8 , Fas , Mapk14 , Mapk8 , Mapk9 , Ppp2ca , Serpine1
tumor necrosis factor mediated signaling pathwayCasp8
type 1 diabetes mellitus pathwayFas
type 2 diabetes mellitus pathwayMapk8 , Mapk9 , Prkcd
type II interferon signaling pathwayAkt1 , Crebbp , Ep300 , Prkcd
ubiquitin/proteasome degradation pathwayBrca1 , Mdm2 , Rchy1 , Rfwd2 , Siah1 , Skp2 , Ube2d1
vascular endothelial growth factor signaling pathwayAkt1 , Casp9 , Mapk14 , Prkcd
vinblastine pharmacodynamics pathwayCdkn1a , Tp53
vincristine pharmacodynamics pathwayCdkn1a , Tp53
vindesine pharmacodynamics pathwayCdkn1a , Tp53
vinorelbine pharmacodynamics pathwayCdkn1a , Tp53
Wnt signaling pathwayCcnd1 , Ccnd2 , Ccnd3 , Crebbp , Csnk1a1 , Csnk1e , Ep300 , Gsk3b , Mapk8 , Mapk9 , Ppp2ca , Siah1 , Tp53
Wnt signaling, canonical pathwayCrebbp , Csnk1a1 , Csnk1g1 , Gsk3b , Tsc2
Wnt signaling, non-canonical pathwayCsnk1a1 , Mapk8 , Mapk9
xanthinuria disease pathwayRrm2
xanthinuria disease pathway, type IRrm2
xanthinuria disease pathway, type IIRrm2
Phenotype Annotations Associated with Genes in the p53 signaling pathway

References Associated with the p53 signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: