NON-SMALL CELL LUNG CANCER PATHWAY (PW:0000705)

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Description

Lung cancer, a major cause of cancer mortality, has been assigned to two types: small-cell (SCLC) and non-small cell lung cancer (NSCLC). The first, an extremely aggressive form of cancer accounts for ~20% of cases while the second accounts for the remaining ~80%. NSCLC itself is comprised of three subtypes: squamous- and large-cell carcinoma and adenocarcinoma. Of the three, the most prevalent type is adenocarcinoma. Well documented contributors to NSCLC are mutations in the epidermal growth f

Pathway Diagram:

Elsevier Inc. Lung Neoplasms cisplatin_DNA_adducts cisplatin drug pathway Map2k1 Braf Kras Egfr Erbb2 Pten Akt1 altered epidermal growth factor/neuregulin signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway Pik3ca cisplatin_DNA_adducts ---| Lung Neoplasms cisplatin drug pathway ---> cisplatin_DNA_adducts Met gefitinib drug pathway ---> Egfr altered scatter factor/hepatocyte growth factor signaling pathway ---> altered epidermal growth factor/neuregulin signaling pathway gefitinib drug pathway potential NSCLC miRNA ---> Lung Neoplasms deregulated miRNA ---> deregulated target translation deregulated target translation deregulated miRNA altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered regulation of target genes altered scatter factor/hepatocyte growth factor signaling pathway altered regulation of target genes altered expression of target genes altered p53 signaling pathway ---> altered expression of target genes altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered regulation of target genes altered scatter factor/hepatocyte growth factor signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes Tp53 altered scatter factor/hepatocyte growth factor signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway altered epidermal growth factor/neuregulin signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered epidermal growth factor/neuregulin signaling pathway altered p53 signaling pathway potential NSCLC miRNA
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Genes in Pathway:

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non-small cell lung cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:5133243
RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:5133242
RGD:5133243
RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6907045
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6907045
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6907045
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6907045
G E2f3 E2F transcription factor 3 JBrowse link 17 36,334,136 36,408,831 RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:5133241
RGD:5133242
RGD:6907045
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:5133243
RGD:6907045
G Fhit fragile histidine triad JBrowse link 15 15,697,292 16,862,873 RGD:6907045
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:5133242
RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:5133242
RGD:5133243
RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:5133241
RGD:5133242
RGD:5133243
G Nras neuroblastoma RAS viral oncogene homolog JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:5133242
RGD:5133243
RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:6907045
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:6907045
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6907045
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6907045
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:5133242
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rarb retinoic acid receptor, beta JBrowse link 15 9,915,223 10,262,599 RGD:6907045
G Rassf1 Ras association domain family member 1 JBrowse link 8 116,307,149 116,318,289 RGD:6907045
G Rassf5 Ras association domain family member 5 JBrowse link 13 47,956,754 48,022,333 RGD:6907045
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6907045
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6907045
G Rxrb retinoid X receptor beta JBrowse link 20 3,822,673 3,829,138 RGD:6907045
G Rxrg retinoid X receptor gamma JBrowse link 13 85,818,473 85,868,555 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Stk4 serine/threonine kinase 4 JBrowse link 3 160,467,552 160,546,540 RGD:6907045
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:5133242
RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwayaltered phosphatidylinositol 3-kinase-Akt signaling pathwayA phosphatidylinositol 3-kinase-Akt signaling pathway that deviates from what its normal course should be
Pathwaycisplatin drug pathwayA platinum (Pt)-containing drug
Pathwayaltered extracellular signal-regulated pathwayA Raf/Mek/Erk signaling pathway that deviates from what its normal course should be. Aberrant Raf/Mek/Erk signaling has been implicated in many types of cancer.
Pathwayaltered scatter factor/hepatocyte growth factor signaling pathwayA scatter factor/hepatocyte growth factor signaling pathway that deviates from what its normal course should be
Pathwayaltered p53 signaling pathwayaltered p53 signaling pathway
Pathwayaltered epidermal growth factor/neuregulin signaling pathwayAn epidermal growth factor/neuregulin signaling pathway that deviates from what its normal course should be.
Functional Classpotential NSCLC miRNAderegulated miRNA that could serve as early detection markers
Pathwaygefitnib drug pathwayThe pharmacokinetics and pharmacodynamics pathway of gefitinib, a selective inhibitor of Egfr

Pathway Gene Annotations

Disease Annotations Associated with Genes in the non-small cell lung cancer pathway
Disease TermsGene Symbols
2-HydroxyglutaricaciduriaSos2
Abnormalities, MultipleKras , Mapk1 , Pten
Activated PI3K-delta SyndromePik3cd
Acute Kidney InjuryBad , Egf , Egfr , Met , Rb1 , Tgfa , Tp53
Acute Lung InjuryEgfr
AdenocarcinomaCcnd1 , Cdkn2a , Egfr , Erbb2 , Kras , Met , Pik3ca , Pten , Rarb , Rassf1 , Tp53
Adenocarcinoma of EsophagusCdkn2a , Pik3ca , Tp53
Adenocarcinoma of LungBraf , Egfr , Erbb2 , Foxo3 , Hras , Kras , Map2k1 , Pik3ca , Sos1 , Tp53
Adenocarcinoma, Bronchiolo-AlveolarEgfr , Kras , Tp53
Adenocarcinoma, Clear CellTp53
Adenocarcinoma, FollicularKras
AdenomaKras , Tp53
Adenoma, Liver CellHras , Kras , Pten
Adenomatous Polyposis ColiAkt1 , Egfr
Adrenal Gland NeoplasmsCdkn2a , Rb1 , Tp53
Adrenocortical CarcinomaBraf , Cdkn2a , Egfr , Rb1 , Tp53
Adrenocortical Carcinoma, HereditaryTp53
Adrenocortical Carcinoma, PediatricTp53
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Aging, PrematureCdkn2a , Tp53
AIDS-Associated NephropathyEgf
Alzheimer DiseaseAkt1 , Bad , E2f1 , Egf , Egfr , Foxo3 , Hras , Pik3r1 , Tp53
AmeloblastomaBraf
Amphetamine-Related DisordersAkt1 , Fhit
Amyotrophic Lateral SclerosisAkt1 , Casp9 , Tp53
Amyotrophic Lateral Sclerosis 1Rxra
Angina, UnstableAkt1
AnisometropiaPten
Aortic Valve InsufficiencyEgfr
Aortic Valve StenosisEgfr
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arsenic PoisoningTp53
ArteriosclerosisMet
Arthritis, ExperimentalAkt1 , Cdkn2a , Egfr , Nras , Pik3cd
Arthritis, JuvenileKras , Mapk1
Arthritis, RheumatoidCdk6 , Foxo3
AsthmaEgfr , Pten
AstrocytomaAkt1 , Braf , Kras , Met , Tp53
AtaxiaPten
Ataxia-Oculomotor Apraxia 3Pik3r5
AtherosclerosisAkt1
AtrophyMapk3
Autism Spectrum DisorderMapk3
Autistic DisorderHras , Met , Prkcb , Pten
Autoimmune Lymphoproliferative SyndromeNras
Autoimmune Lymphoproliferative Syndrome, Type IVKras , Nras
Autoinflammation, Antibody Deficiency, and Immune Dysregulation, PLCG2-AssociatedPlcg2
Bacterial InfectionsCasp9
Balkan NephropathyTp53
Bardet-Biedl SyndromeAkt3
Benign Skin NeoplasmsHras
Bile Duct NeoplasmsEgfr , Met
Bipolar DisorderAkt1
Bone Diseases, DevelopmentalTp53
Bone Marrow NeoplasmsTp53
Brain InjuriesAkt1 , Bad
Brain IschemiaAkt1 , Bad , Casp9 , Map2k1 , Mapk1 , Mapk3 , Prkca , Rb1 , Tp53
Brain NeoplasmsCcnd1 , Cdk4 , Cdkn2a , Tp53
Brain Stem NeoplasmsCdk4 , Cdk6 , Cdkn2a
Breast AdenocarcinomaAkt1 , Kras , Pik3ca , Tp53
Breast Cancer, FamilialPik3r3
Breast NeoplasmsAkt1 , Akt2 , Bad , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , Egfr , Erbb2 , Fhit , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Met , Pdpk1 , Pik3ca , Pik3r1 , Plcg1 , Prkca , Pten , Raf1 , Rarb , Rassf1 , Rb1 , Rxrb , Tp53
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Akt1 , Pik3ca
Burkitt LymphomaPik3r1
BurnsBad , Ccnd1
Cafe au lait Spots, MultipleSos1
CalcinosisErbb2
CarcinogenesisBraf , Cdkn2a , Erbb2 , Kras
CarcinomaCcnd1 , Cdk4 , Egfr , Fhit , Hras , Kras , Met , Pik3r1 , Pten , Rb1 , Tp53
Carcinoma in SituAkt1 , Cdkn2a , Pten , Rb1
Carcinoma, Adenoid CysticCcnd1 , Foxo3 , Hras , Map2k2 , Pik3ca , Pten , Tp53
Carcinoma, Basal CellErbb2 , Pik3ca , Rb1 , Tp53
Carcinoma, Ductal, BreastCdkn2a , Fhit
Carcinoma, EmbryonalRb1
Carcinoma, EndometrioidEgfr , Erbb2 , Kras , Pten
Carcinoma, HepatocellularAkt2 , Braf , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , Egfr , Fhit , Hras , Kras , Met , Pik3ca , Pten , Rb1 , Tgfa , Tp53
Carcinoma, Intraductal, NoninfiltratingCcnd1 , Erbb2 , Prkca , Rb1 , Tp53
Carcinoma, Large CellMet , Prkca
Carcinoma, LobularCcnd1 , Erbb2
Carcinoma, Non-Small-Cell LungAkt1 , Braf , Cdkn2a , Egfr , Erbb2 , Fhit , Foxo3 , Hras , Kras , Map2k1 , Met , Nras , Pik3ca , Pten , Raf1 , Rassf1 , Rb1 , Tgfa , Tp53
Carcinoma, Pancreatic DuctalCdkn2a , Egf , Kras , Met , Rxra
Carcinoma, Renal CellAkt1 , Bad , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Fhit , Kras , Map2k1 , Met , Pik3ca , Pten , Rassf1 , Rb1 , Tp53
Carcinoma, Small CellRassf1 , Rb1 , Tp53
Carcinoma, Squamous CellAkt1 , Ccnd1 , Cdkn2a , Egfr , Fhit , Hras , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Rarb , Tp53
Carcinoma, Squamous Cell of Head and NeckAkt1 , Cdkn2a , Egfr , Pik3ca , Pten , Tp53
Carcinoma, Transitional CellCcnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Hras , Kras , Nras , Rassf1 , Tp53
Cardiofaciocutaneous SyndromeBraf , Hras , Kras , Map2k1 , Map2k2
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Bad , Egfr , Mapk1 , Met , Prkca , Prkcb , Pten , Rb1
CardiomyopathiesAkt1 , Kras , Mapk1 , Mapk3 , Tp53
Cardiomyopathy, AlcoholicRxra
Cardiomyopathy, DilatedEgfr , Erbb2 , Kras , Prkca , Prkcb , Raf1
CARDIOMYOPATHY, DILATED, 1NNRaf1
Cardiomyopathy, HypertrophicKras , Raf1 , Rassf1 , Sos1 , Tp53
Cardiomyopathy, Hypertrophic, FamilialKras , Raf1 , Sos1
Cardiovascular AbnormalitiesMap2k1
Carotid Artery DiseasesTp53
Carotid Artery InjuriesFoxo3
CataractTp53
Cecal NeoplasmsCcnd1 , Kras , Tp53
Cell Transformation, NeoplasticCcnd1 , Hras , Kras , Tp53
Central Nervous System NeoplasmsTp53
Ceroid Lipofuscinosis, Neuronal, 6Mapk1 , Mapk3
Cervical Intraepithelial NeoplasiaCcnd1 , Cdk4 , Cdkn2a , Pten , Rb1
Chemotherapy-Induced Febrile NeutropeniaTp53
ChloracneCdk6 , Egfr
CholangiocarcinomaEgfr , Erbb2 , Kras , Met , Pten , Tp53
Cholesteatoma, Middle EarTp53
Choroid Plexus CarcinomaTp53
Chromosome 17 DeletionTp53
Chromosome AberrationsCdk6
Chromosome DeletionCdkn2a
Cocaine-Related DisordersMapk1 , Mapk3
Cognition DisordersMet
Colitis, UlcerativeTp53
Colonic NeoplasmsAkt1 , Akt2 , Bad , Braf , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Kras , Nras , Pik3ca , Pik3r1 , Tp53
Colorectal NeoplasmsAkt1 , Braf , Ccnd1 , Egfr , Kras , Met , Nras , Pik3ca , Prkcb , Tp53
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Copper-Overload CirrhosisMet
Coronary Artery DiseaseAkt1
Coronary RestenosisMapk1 , Tp53
Costello SyndromeBraf , Hras , Kras , Map2k1 , Map2k2
COWDEN SYNDROME 5Pik3ca
Craniofacial AbnormalitiesEgfr , Pten , Tp53
CraniopharyngiomaBraf
Currarino TriadPik3ca
Cystadenocarcinoma, SerousTp53
Deafness, Autosomal Recessive 97Met
DementiaE2f1 , Egfr
Dementia, VascularTp53
Demyelinating DiseasesTp53
Developmental DisabilitiesAkt3 , Pten
Diabetes Insipidus, NephrogenicPrkca
Diabetes MellitusPten
Diabetes Mellitus, ExperimentalAkt1 , Bad , Casp9 , Egfr , Foxo3 , Hras , Mapk1 , Mapk3 , Met , Pik3r1 , Plcg1 , Prkca , Prkcb , Tp53
Diabetes Mellitus, Type 1Casp9 , Cdk4 , E2f1 , Egfr
Diabetes Mellitus, Type 2Akt1 , Akt2 , Bad , Casp9 , Cdk4 , Egfr , Pik3r1 , Prkcb
Diabetic CardiomyopathiesBad , Erbb2
Diabetic CystopathyBad
Diabetic NephropathiesEgf , Mapk1 , Prkcb , Pten , Tp53
Diabetic NeuropathiesBad
Diabetic RetinopathyCasp9 , Egfr , Hras
Disease Models, AnimalAkt1 , Erbb2 , Kras , Mapk1 , Mapk3 , Prkcg , Tp53
Disease ProgressionEgfr , Erbb2 , Hras , Pten , Rxrb
Drug-Induced Liver InjuryBad
Drug-induced NeutropeniaTp53
Drug-Related Side Effects and Adverse ReactionsTp53
Dysembryoplastic Neuroepithelial TumorBraf
Dyskeratosis Congenita, Autosomal RecessiveTp53
Dysplastic Nevus SyndromeCdkn2a
EdemaCasp9
EmphysemaTp53
Encephalitis, ViralE2f1
Encephalomyelitis, Autoimmune, ExperimentalCasp9
Endometrial HyperplasiaKras , Pten
Endometrial NeoplasmsCcnd1 , Cdk4 , Cdkn2a , Erbb2 , Fhit , Kras , Met , Pik3ca , Prkca , Pten , Rassf1 , Rb1 , Tp53
EndometriosisEgfr , Kras , Rarb
Enterocolitis, NecrotizingEgf
Epidermal NevusHras , Kras , Nras , Pik3ca
EpilepsyAkt1
Epilepsy, Temporal LobeFoxo3
Erectile DysfunctionAkt1 , Bad , Ccnd1
Esophageal NeoplasmsCcnd1 , Cdkn2a , Egfr , Erbb2 , Met , Tp53
Esophageal Squamous Cell CarcinomaCcnd1 , Cdkn2a , Egfr , Rb1 , Tp53
Esophagitis, PepticEgfr
Facial AsymmetryPik3ca
Familial Cold Autoinflammatory Syndrome 3Plcg2
Fatty LiverPten
Fetal DiseasesPrkcb
Fibromatosis, GingivalSos1
Fibromatosis, Gingival, 1Sos1
FibrosisAkt1
Gallbladder NeoplasmsEgf , Egfr , Erbb2 , Kras , Met , Tgfa , Tp53
GastrinomaMet
GastroenteritisTgfa
Gastrointestinal NeoplasmsErbb2 , Pik3ca , Pten
Genetic Diseases, InbornMapk1 , Pik3r2 , Pten
Genetic Predisposition to DiseaseTgfa
Genomic InstabilityCcnd1
GerminomaBraf , Cdkn2a
Giant Pigmented Hairy NevusHras , Nras
GlaucomaBad , Cdkn2a
Glaucoma, Primary Open AngleTp53
GlioblastomaAkt1 , Cdk6 , Cdkn2a , Egfr , Erbb2 , Met , Pten
GliomaAkt2 , Bad , Braf , Cdkn2a , Egfr , Erbb2 , Met , Pik3ca , Pten , Raf1 , Rassf1 , Tp53
GliosisMapk1 , Mapk3
GlomerulonephritisMapk1
Graft vs Host DiseaseTp53
Granulosa Cell TumorCdkn2a , Fhit
Graves DiseaseTp53
Growth DisordersPik3ca
Hamartoma Syndrome, MultipleAkt1 , Egfr , Pik3ca , Pten
Head and Neck NeoplasmsEgfr , Mapk1 , Mapk3 , Rarb , Tgfa
Heart ArrestAkt1
Heart DiseasesCasp9
Heart FailureErbb2 , Pdpk1 , Prkca , Prkcb , Tp53
Heart Septal Defects, VentricularBraf
HELLP SyndromeErbb2
HemangiomaPten
Hemangioma, CapillaryAkt3
HemangiosarcomaCcnd1 , Hras , Kras , Plcg1 , Tp53
HemimegalencephalyPik3ca
Hepatitis, AnimalMet
Hepatitis, ChronicMet
HepatoblastomaTgfa , Tp53
HepatomegalyPten
Hernia, DiaphragmaticRxra
Hernias, Diaphragmatic, CongenitalMet
Hirschsprung DiseaseErbb2
Huntington DiseaseE2f1 , Egfr
HyperalgesiaMapk1 , Mapk3 , Prkcb , Prkcg , Raf1
HyperglycemiaPrkcb
HyperinsulinismPten
HyperoxiaCdk4
HyperparathyroidismCcnd1
HyperplasiaAkt1 , Ccnd1 , Cdkn2a , Egfr , Pik3ca
Hypersensitivity, ImmediateEgfr
HypertensionAkt1 , Akt2 , Bad , Cdkn2a , Egfr , Kras , Pik3r1 , Prkca , Prkcb , Pten , Tp53
Hypertension, PortalPik3r1 , Pten
Hypertension, PulmonaryEgfr , Tgfa , Tp53
HypertrophyMapk1 , Mapk3 , Pten
Hypertrophy, Left VentricularEgfr , Foxo3 , Prkca , Prkcb , Pten
Hypertrophy, Right VentricularAkt1 , Prkca , Tgfa
HypoglycemiaAkt2 , Pik3r1
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
Hypomagnesemia PrimaryEgf
HypothyroidismBad
HypotrichosisRb1
Hypotrichosis, Localized, Autosomal Recessive, 3Rb1
Hypoxia-Ischemia, BrainFoxo3
Immune System DiseasesPrkcb
Immunodeficiency 14Pik3cd
Immunodeficiency 36Pik3r1
Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal DementiaEgf
Infarction, Middle Cerebral ArteryBad
Infertility, FemaleMapk1 , Mapk3 , Tp53
Infertility, MaleTp53
InflammationAkt1 , Egfr , Tgfa
Inflammatory Bowel DiseasesRassf1
Insulin ResistanceAkt2 , Bad , Egfr , Pik3r1 , Prkcb , Pten , Rb1
InsulinomaTgfa
Intellectual DisabilityKras , Prkcg , Pten
Intermittent ClaudicationBad
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsPrkca
Intestinal PolypsCcnd1
Intestinal Pseudo-ObstructionRb1
Intimal HyperplasiaFoxo3
IschemiaAkt2 , Prkca , Raf1 , Tp53
Ischemic Attack, TransientBad , Casp9 , Cdkn2a , Pten
Juvenile Polyposis SyndromePten
KeratosisTp53
Keratosis, SeborrheicPik3ca
Kidney DiseasesMapk1
Kidney NeoplasmsAkt1 , Braf , Ccnd1 , Cdkn2a , Erbb2 , Kras , Mapk1 , Mapk3 , Met , Raf1 , Rassf1 , Rassf5
Language Development DisordersPten
Laryngeal NeoplasmsEgfr
LeiomyomaPten
LeiomyosarcomaCdkn2a
LEOPARD SyndromeBraf , Pten , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD syndrome, 2Raf1
LeukemiaBad , Ccnd1 , Cdkn2a , Nras , Pten , Tp53
Leukemia, ExperimentalCdkn2a , Nras
Leukemia, Hairy CellMap2k1
Leukemia, Lymphocytic, Chronic, B-CellCcnd1 , Tp53
Leukemia, Megakaryoblastic, AcutePten , Tp53
Leukemia, Megakaryoblastic, of Down SyndromeNras , Tp53
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveCdkn2a
Leukemia, Myeloid, AcuteCcnd1 , Cdk6 , Cdkn2a , Kras , Met , Nras , Tp53
Leukemia, Myelomonocytic, ChronicNras
Leukemia, Myelomonocytic, JuvenileKras , Nras
Leukemia, Promyelocytic, AcuteAkt1 , Nras
Leukemia, T-CellCdkn2a
Leukemia-Lymphoma, Adult T-CellNras , Plcg1 , Prkcb , Tp53
Leukoplakia, OralTp53
Leydig Cell TumorCdk4
Li-Fraumeni SyndromeTp53
Li-Fraumeni Syndrome 2Tp53
Li-Fraumeni-Like SyndromeTp53
Lichen Planus, OralTp53
Lip NeoplasmsTp53
Lipodystrophy, Familial PartialAkt2
LipomaPten
LipomatosisPten
LiposarcomaCdk4
Liver Cirrhosis, ExperimentalCdk4 , Met , Prkcb , Rxra
Liver Diseases, ParasiticKras , Tp53
Liver Failure, AcuteMet
Liver NeoplasmsBraf , Ccnd1 , Cdkn2a , Fhit , Hras , Kras , Met , Pik3ca , Raf1 , Tgfa , Tp53
Liver Neoplasms, ExperimentalCcnd1 , Hras , Kras , Map2k1 , Met , Rb1 , Rxra , Tgfa , Tp53
Liver Reperfusion InjuryBad
Long QT SyndromePten
Low Tension GlaucomaTp53
Lung DiseasesEgfr
Lung InjuryTgfa
Lung NeoplasmsAkt1 , Braf , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Fhit , Hras , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Pten , Raf1 , Rarb , Rassf1 , Tp53
Lupus NephritisEgf
Lymphatic MetastasisEgfr , Erbb2 , Pten , Tp53
LymphomaCdkn2a , Kras , Nras , Pten , Tp53
Lymphoma, B-CellNras
Lymphoma, B-Cell, Marginal ZoneTp53
Lymphoma, Large B-Cell, DiffuseCdkn2a , Pdpk1 , Pik3ca , Pik3cb , Pik3cd
Lymphoma, Mantle-CellCcnd1 , Pik3cd
Lymphoma, Non-HodgkinBraf , Ccnd1 , Tp53
Lymphoma, T-CellAkt1 , Tp53
Lymphoma, T-Cell, CutaneousBraf , Cdkn2a , Plcg1 , Tp53
Macrocephaly Autism SyndromePten
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
Macular DegenerationBad
Malformations of Cortical DevelopmentAkt3 , Pik3ca
Mammary Neoplasms, AnimalCcnd1 , Cdk4 , Egfr , Erbb2 , Hras , Pik3r1 , Rassf1 , Rb1
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Egfr , Erbb2 , Hras , Pik3r1 , Pten , Rb1 , Rxra , Tp53
Mandibular NeoplasmsBraf
Marijuana AbuseAkt1
Median NeuropathyErbb2
MedulloblastomaCdk6 , Erbb2 , Rassf1 , Rb1 , Tp53
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
MelanomaBraf , Cdkn2a , E2f1 , Map2k1 , Map2k2 , Nras , Pik3ca , Pten , Tp53
Melanoma Astrocytoma SyndromeCdkn2a
Melanoma, Cutaneous MalignantCdk4 , Cdkn2a
Melanoma, Cutaneous Malignant, Susceptibility To, 1Braf , Cdkn2a , Nras , Pik3ca , Pten , Tp53
Melanoma, Cutaneous Malignant, Susceptibility To, 2Cdkn2a
Melanoma, Cutaneous Malignant, Susceptibility to, 3Cdk4
Melanoma-Pancreatic Cancer SyndromeCdkn2a
MeningiomaAkt1 , Pten
Meningioma, FamilialPten
MesotheliomaCdkn2a , Egfr , Fhit , Rassf1 , Tp53
Mesothelioma, MalignantCdk6 , Cdkn2a , Egfr , Met , Raf1 , Rxra , Tp53
Micronuclei, Chromosome-DefectiveCdkn2a , Rassf1
Microphthalmia, Syndromic 12Rarb
Microsatellite InstabilityBraf
Mixed Tumor, MullerianCdkn2a
Mood DisordersAkt1
Motor Skills DisordersPten
Mouth NeoplasmsCdkn2a , Erbb2 , Hras , Kras , Nras , Pik3ca , Tp53
MucositisTgfa
Multiple MyelomaCcnd1 , Cdkn2a , Kras , Met , Nras , Tp53
Multiple Organ FailureMapk1
Muscular AtrophyAkt1
Myelodysplastic SyndromesCdkn2a , Nras , Tp53
Myeloproliferative DisordersKras , Nras
Myocardial InfarctionAkt1 , Mapk1 , Tp53
Myocardial IschemiaCcnd1 , Erbb2 , Rxrg
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Casp9 , Mapk1 , Prkcb , Pten , Tp53
Myopathy, Congenital, with Excess of Muscle SpindlesHras
Nasal PolypsMet
Nasopharyngeal carcinomaAkt2 , Ccnd1 , Cdkn2a , Erbb2 , Kras , Pik3ca , Pten , Tp53
Nasopharyngeal NeoplasmsCcnd1 , Egfr , Tp53
Nematode InfectionsPik3r1
Neoplasm InvasivenessCdkn2a , Egfr , Hras , Mapk1 , Mapk3 , Met , Pten
Neoplasm MetastasisAkt2 , Braf , Cdkn2a , Egfr , Erbb2 , Kras , Mapk1 , Mapk3 , Met , Pten , Rb1 , Rxra , Tp53
Neoplasm Recurrence, LocalEgfr , Erbb2
NeoplasmsCdkn2a , Erbb2 , Kras , Tp53
Neoplasms, Cystic, Mucinous, and SerousMet
Neoplasms, ExperimentalCcnd1 , Cdk4 , Erbb2 , Hras , Kras , Nras , Rb1 , Tp53
Neoplasms, Germ Cell and EmbryonalCdk4 , Cdkn2a , Erbb2 , Fhit
Neoplastic ProcessesHras
Neoplastic Syndromes, HereditaryCdk4 , Cdkn2a , Met , Pik3ca , Pten , Tp53
Nerve DegenerationMapk1 , Mapk3 , Tgfa
Nerve Sheath NeoplasmsCdkn2a , Met , Tp53
Nervous System DiseasesCasp9 , Tp53
NeurilemmomaCdkn2a
NeuroblastomaCdkn2a , Hras , Kras , Met , Nras , Rassf1 , Rassf5 , Tp53
Neurocutaneous MelanosisNras
Neuroendocrine TumorsBraf
NeurofibrosarcomaNras
Neurogenic InflammationRxra
NevusBraf
Nevus, PigmentedNras
Nevus, Sebaceous of JadassohnHras , Kras , Nras
Nonseminomatous Germ Cell TumorBraf
Nonsyndromic DeafnessMet
Noonan like syndromeSos1
Noonan SyndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1 , Sos1
Noonan syndrome 3Kras
Noonan Syndrome 4Sos1
Noonan Syndrome 5Raf1
Noonan Syndrome 6Nras
Noonan Syndrome 7Braf
NOONAN SYNDROME 9Sos2
Nose NeoplasmsTp53
ObesityAkt1 , Akt2 , Bad , Cdk4 , Cdkn2a , Egfr , Foxo3 , Pik3r1 , Prkcb , Rb1 , Rxra
Obsessive-Compulsive DisorderHras
Odontogenic MyxomaTp53
Optic Atrophy, Hereditary, LeberTp53
Oral Squamous Cell CarcinomaMet
Oral Submucous FibrosisTp53
Oropharyngeal NeoplasmsTp53
OsteoarthritisBad , Cdkn2a
Osteoarthritis, KneeTgfa
Osteofibrous DysplasiaMet
OsteosarcomaEgfr , Met , Rb1 , Tp53
Ovarian Epithelial CancerPik3ca , Tp53
Ovarian NeoplasmsAkt1 , Akt2 , Braf , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Fhit , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3r1 , Prkca , Pten , Rassf1 , Rb1 , Tp53
Paget's Disease, MammaryErbb2
PainAkt1
Pancreatic CarcinomaCdkn2a , Kras , Tp53
Pancreatic NeoplasmsAkt2 , Cdkn2a , Egf , Egfr , Kras , Met , Pten , Rb1 , Rxra , Tgfa , Tp53
PancreatitisEgf , Met
Pancreatitis, ChronicBad
Pancreatitis, Experimental, Acute Kras
PapillomaCcnd1 , Egfr , Erbb2 , Hras
Papilloma, Choroid PlexusTp53
Papillomavirus InfectionsCdkn2a
Paranasal Sinus NeoplasmsTp53
ParaplegiaAkt1
Parkinson DiseaseAkt1 , Egf , Egfr , Erbb2
Parkinsonian DisordersBad , Egfr
Penile NeoplasmsCcnd1 , Hras , Kras , Pik3ca , Tp53
PeriodontitisMet
Peripheral Nervous System DiseasesCasp9 , Cdkn2a
Persistent Hyperplastic Primary VitreousCdkn2a
Phobic DisordersHras
Phyllodes TumorEgfr , Rb1 , Tp53
Pituitary NeoplasmsPrkca , Rb1
PlasmacytomaCdkn2a
Pleomorphic Xanthoastrocytoma Braf
PneumoniaEgf
Pneumonia, PneumococcalMapk1 , Mapk3
PoisoningCdkn2a
Polycystic Kidney DiseasesPlcg1
Polycystic Kidney, Autosomal RecessiveAkt1 , Egfr , Pik3ca
PolydactylyPten
PolymicrogyriaAkt3
PolyploidyTp53
PolyuriaPrkca
Pre-EclampsiaErbb2
Precancerous ConditionsCcnd1 , Cdkn2a , Hras , Tp53
Precursor B-Cell Lymphoblastic Leukemia-LymphomaCcnd1 , Cdkn2a , Tp53
Precursor Cell Lymphoblastic Leukemia-LymphomaCcnd1 , Cdk6 , Cdkn2a , Kras , Nras , Rb1 , Tp53
Precursor T-Cell Lymphoblastic Leukemia-LymphomaCdkn2a , Kras
Primary MyelofibrosisTp53
Prostate Cancer, SomaticPten
Prostatic HyperplasiaBad , Cdk4 , Pten
Prostatic Intraepithelial NeoplasiaCcnd1 , Kras , Pten , Rxra
Prostatic NeoplasmsAkt1 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , Egfr , Erbb2 , Fhit , Foxo3 , Kras , Map2k1 , Mapk3 , Met , Nras , Pik3ca , Pik3cd , Pik3r1 , Prkca , Pten , Rassf1 , Rb1 , Rxra , Tgfa , Tp53
Proteus SyndromeAkt1 , Pten
PsoriasisTgfa , Tp53
Psychoses, Substance-InducedAkt1
Pten Hamartoma Tumor Syndrome with Granular Cell TumorPten
PterygiumTp53
Pulmonary Disease, Chronic ObstructiveEgfr , Foxo3 , Tp53
Pulmonary EdemaTgfa
Pulmonary FibrosisBad , Egfr , Tgfa
Pulmonary Valve StenosisHras
Radiation Injuries, ExperimentalMapk1 , Mapk3
RASopathiesBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1 , Sos1
Rectal NeoplasmsEgfr , Nras , Pik3ca
RecurrenceErbb2 , Hras , Kras
Renal FibrosisKras , Mapk1
Reperfusion InjuryAkt1 , Bad , Casp9 , Ccnd1 , Egf , Met , Pik3r1 , Prkca , Pten , Tp53
Retina Reperfusion InjuryBad
Retinal DetachmentCasp9
Retinitis PigmentosaPrkcg
RetinoblastomaRb1
RhabdomyosarcomaCdkn2a , Tp53
Salivary Gland NeoplasmsCcnd1
SarcomaMet , Pik3ca , Tp53
Sarcoma Family Syndrome of Li and FraumeniCdkn2a , Tp53
Sarcoma, ExperimentalKras , Nras
Sarcoma, KaposiTp53
Sarcoma, MyeloidKras
SchistosomiasisRassf1
SchizophreniaAkt1 , Egf , Egfr , Mapk3 , Met , Pik3cb , Tp53
Sciatic NeuropathyRarb , Rxra
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
SeizuresBad , Ccnd1 , Pten
SeminomaFhit , Hras , Kras , Rb1
Senior Loken SyndromeAkt3
SepsisBad , Mapk1 , Mapk3 , Rxra
Septic PeritonitisPik3r1
Sezary SyndromeBraf , Cdkn2a , Mapk1 , Plcg1 , Pten , Rb1 , Tp53
Shock, HemorrhagicBad , Mapk1
SHORT SyndromePik3r1
SilicosisPrkcb
SinusitisMet
Skin DiseasesPten
Skin NeoplasmsAkt1 , Hras , Tp53
Small Cell Lung CarcinomaEgfr , Pten , Rb1 , Tp53
Small-For-Size SyndromeBad
Smith-Magenis SyndromeErbb2 , Grb2 , Prkca
Spinal Cord InjuriesAkt1 , Egfr , Foxo3 , Met , Tp53
Spinal Cord Reperfusion InjuryBad
Spinocerebellar Ataxia 14Prkcg
Spinocerebellar AtaxiasPrkcg
Splenic NeoplasmsHras
Spondylocostal Dysostosis 5Mapk3
Squamous Cell Carcinoma of the LungKras
Squamous Cell Carcinoma of the TongueEgfr , Met , Tp53
Status EpilepticusCcnd1 , Foxo3 , Prkcb
Stevens-Johnson SyndromeRb1
Stomach DiseasesPten
Stomach NeoplasmsCcnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Fhit , Hras , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Prkcb , Rarb , Rxrb , Tgfa , Tp53
Stomach UlcerBad
StrokeAkt1 , Tgfa
Substance Withdrawal SyndromeMapk1 , Mapk3
Substance-Related DisordersFhit , Pten
T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac MalformationsStk4
Tachycardia, VentricularRaf1
Testicular Germ Cell TumorHras
ThrombosisPik3cb
ThymomaCdkn2a , Tp53
Thymus NeoplasmsTp53
Thyroid Cancer, FollicularBraf , Hras , Nras , Pten
Thyroid Cancer, MedullaryKras
Thyroid cancer, papillaryBraf
Thyroid Carcinoma, AnaplasticTp53
Thyroid NeoplasmsBraf , Ccnd1 , Hras , Kras , Rxra , Tp53
Tobacco Use DisorderEgfr
Tongue NeoplasmsCdkn2a , Hras , Tp53
Translocation, GeneticCdkn2a
Trichilemmoma Hras
Trigeminal Nerve InjuriesTp53
Trigeminal NeuralgiaMapk1 , Mapk3 , Prkcg
TrisomyCdkn2a
Tumor Predisposition SyndromeCdk4 , Cdkn2a , Met , Pten , Tp53
Ureteral ObstructionAkt1
Urethral ObstructionMapk1
Urinary Bladder DiseasesRassf1
Urinary Bladder NeoplasmsAkt1 , Casp9 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Fhit , Hras , Kras , Prkca , Pten , Rassf1 , Rb1 , Tp53
Urinary IncontinenceMapk1
Urogenital NeoplasmsCdkn2a , Tp53
Urologic NeoplasmsCcnd1 , Erbb2 , Fhit , Tp53
Uterine Cervical NeoplasmsCcnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Fhit , Hras , Kras , Nras , Pten , Rarb , Rassf1 , Tp53
Uterine NeoplasmsKras
VACTERL/VATER Association with HydrocephalusPten
VaricoceleCasp9
Ventilator-Induced Lung InjuryAkt1
von Hippel-Lindau DiseaseCcnd1
Vulvar Lichen SclerosusCdkn2a , Tp53
Vulvar NeoplasmsCdkn2a , Fhit , Tp53
Wallerian DegenerationErbb2 , Rxra
Weight GainPik3ca
Wilms TumorCdk4 , Cdkn2a , Erbb2
Woolly Hair, Autosomal RecessiveRb1
Wounds and InjuriesEgf
Xeroderma PigmentosumTp53
Zollinger-Ellison SyndromeEgf
Pathway Annotations Associated with Genes in the non-small cell lung cancer pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
adenosine signaling pathwayAkt1 , Bad , Braf , Hras , Map2k2 , Mapk1 , Pdpk1 , Pik3ca
aldosterone signaling pathwayKras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2 , Tgfa
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered G1/S transition pathwayCdkn2a
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered p53 signaling pathwayTp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered scatter factor/hepatocyte growth factor signaling pathwayMet
Alzheimer disease pathwayBad , Casp9 , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayBad , Casp9 , Tp53
angiotensin II signaling pathwayPdpk1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg2 , Prkcb , Raf1 , Sos1 , Sos2
basal cell carcinoma pathwayTp53
bile acid transport pathwayRxra
bladder cancer pathwayBraf , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Rassf1 , Rb1 , Tp53
Bone morphogenetic proteins signaling pathwayMapk1
brain-derived neurotrophic factor signaling pathwayGrb2
calcium/calcium-mediated signaling pathwayEgfr , Erbb2 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg
cell cycle pathway, mitoticCcnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Rb1 , Tp53
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rb1 , Tgfa , Tp53
cetuximab pharmacodynamics pathwayEgfr
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcb , Raf1 , Sos1 , Sos2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rb1 , Sos1 , Sos2 , Tp53
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
cytokine mediated signaling pathwayEgf , Egfr , Met
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Egf , Egfr , Pik3ca , Pik3r1 , Plcg1
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5 , Prkca , Prkcg
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1 , Rxra , Rxrb , Rxrg
endocytosis pathwayEgf , Egfr , Hras , Met
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tp53
endothelin signaling pathwayAkt1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Prkca , Prkcg , Raf1
Entamoeba histolyca infection pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
ephrin - ephrin receptor bidirectional signaling axisGrb2 , Hras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Pik3r5 , Plcg1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1 , Sos1 , Sos2 , Tgfa
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayGrb2 , Hras , Pik3r1 , Plcg1 , Plcg2 , Sos1
FasL mediated signaling pathwayAkt1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcg , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1
fibroblast growth factor signaling pathwayAkt1 , Grb2 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1 , Plcg1 , Sos1
forkhead class A signaling pathwayAkt1
G1 phase pathwayCcnd1 , Cdk4
G1/S transition pathwayCcnd1 , Cdk4 , Cdk6 , Cdkn2a , Rb1
gefitinib pharmacodynamics pathwayEgfr
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Pten , Raf1 , Rb1 , Sos1 , Sos2 , Tgfa , Tp53
glutamate signaling pathwayMapk1 , Mapk3 , Prkca , Prkcb , Prkcg
gonadotropin-releasing hormone signaling pathwayEgfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Raf1 , Sos1 , Sos2
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1
Hedgehog signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Grb2 , Hras , Kras , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rxra , Sos1 , Sos2 , Tp53
Huntington disease pathwayCasp9 , Tp53
hypoxia inducible factor pathwayAkt1
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Casp9 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Raf1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Plcg1 , Plcg2 , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Raf1 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Bad , Grb2 , Hras , Pdpk1 , Pik3ca , Pik3r1 , Raf1 , Sos1
interleukin-1 signaling pathwayPik3ca , Pik3r1
interleukin-2 signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Prkcb , Raf1 , Sos1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1 , Sos1 , Sos2
intrinsic apoptotic pathwayBad , Casp9
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Leishmania infection pathwayMapk1 , Mapk3 , Prkcb
long term depressionBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Raf1
long term potentiationBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Raf1
measles infection pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Cdk4 , Cdk6 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tp53
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Egf , Egfr , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Raf1 , Sos1 , Sos2 , Stk4 , Tp53
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Raf1
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mapk1 , Mapk3 , Raf1
myocarditis pathwayCasp9 , Ccnd1
N-cadherin signaling pathwayPik3ca , Pik3r1 , Plcg1
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Raf1 , Sos1 , Sos2 , Tp53
NOD-like receptor signaling pathwayMapk1 , Mapk3
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Fhit , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Pten , Raf1 , Rarb , Rassf1 , Rassf5 , Rb1 , Rxra , Rxrb , Rxrg , Sos1 , Sos2 , Stk4 , Tgfa , Tp53
Notch signaling pathwayCcnd1
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1 , Prkca
nuclear factor, erythroid 2 like 2 signaling pathwayPten
p53 signaling pathwayAkt1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Pten , Rassf1 , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tgfa , Tp53
panitumumab pharmacodynamics pathwayEgfr
Parkinson disease pathwayCasp9
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Hras , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Pten
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Foxo3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1 , Pten
Plasmodium infection pathwayMet
platelet-derived growth factor signaling pathwayBraf , Grb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Prkca , Pten , Raf1 , Sos1
prion diseases pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Sos1 , Sos2 , Tgfa , Tp53
protein kinase C (PKC) signaling pathwayPdpk1 , Prkca , Prkcb , Prkcg
purine metabolic pathwayFhit
Ras family mediated signaling pathwaySos1
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
retinoic acid signaling pathwayRarb , Rxra , Rxrb , Rxrg
ribosome biogenesis pathwayPrkcb
RNA polymerase III transcription pathwayRb1
S phase pathwayCcnd1 , Cdk4
scatter factor/hepatocyte growth factor signaling pathwayGrb2 , Met , Pik3r1 , Plcg1
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , E2f1 , E2f3 , Fhit , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rarb , Rb1 , Rxra , Rxrb , Rxrg , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Mapk1 , Mapk3 , Plcg1
syndecan signaling pathwayEgfr , Hras , Mapk1 , Mapk3 , Prkca
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cdk4 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Raf1 , Sos1 , Sos2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
thyroid cancer pathwayBraf , Ccnd1 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Rxra , Rxrb , Rxrg , Tp53
titanium dioxide nanoparticle response pathwayTp53
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Trail mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayFoxo3 , Grb2 , Pdpk1 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3
trastuzumab pharmacodynamics pathwayEgfr
Trypanosoma brucei infection pathwayPrkca , Prkcb , Prkcg
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type 2 diabetes mellitus pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayCcnd1 , Prkca , Prkcb , Prkcg , Tp53
Phenotype Annotations Associated with Genes in the non-small cell lung cancer pathway

References Associated with the non-small cell lung cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: