NON-SMALL CELL LUNG CANCER PATHWAY (PW:0000705)

View Ontology Report

Description

Lung cancer, a major cause of cancer mortality, has been assigned to two types: small-cell (SCLC) and non-small cell lung cancer (NSCLC). The first, an extremely aggressive form of cancer accounts for ~20% of cases while the second accounts for the remaining ~80%. NSCLC itself is comprised of three subtypes: squamous- and large-cell carcinoma and adenocarcinoma. Of the three, the most prevalent type is adenocarcinoma. Well documented contributors to NSCLC are mutations in the epidermal growth f

Pathway Diagram:

Elsevier Inc. Lung Neoplasms cisplatin_DNA_adducts cisplatin drug pathway Map2k1 Braf Kras Egfr Erbb2 Pten Akt1 altered epidermal growth factor/neuregulin signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway Pik3ca cisplatin_DNA_adducts ---| Lung Neoplasms cisplatin drug pathway ---> cisplatin_DNA_adducts Met gefitinib drug pathway ---> Egfr altered scatter factor/hepatocyte growth factor signaling pathway ---> altered epidermal growth factor/neuregulin signaling pathway gefitinib drug pathway potential NSCLC miRNA ---> Lung Neoplasms deregulated miRNA ---> deregulated target translation deregulated target translation deregulated miRNA altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered regulation of target genes altered scatter factor/hepatocyte growth factor signaling pathway altered regulation of target genes altered expression of target genes altered p53 signaling pathway ---> altered expression of target genes altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered regulation of target genes altered scatter factor/hepatocyte growth factor signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes Tp53 altered scatter factor/hepatocyte growth factor signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway altered epidermal growth factor/neuregulin signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered epidermal growth factor/neuregulin signaling pathway altered p53 signaling pathway potential NSCLC miRNA
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Genes in Pathway:

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non-small cell lung cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:5133243
RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:5133242
RGD:6907045
RGD:5133243
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6907045
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6907045
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6907045
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6907045
G E2f3 E2F transcription factor 3 JBrowse link 17 36,334,136 36,408,831 RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:5133241
RGD:6907045
RGD:5133242
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:5133243
RGD:6907045
G Fhit fragile histidine triad JBrowse link 15 15,697,292 16,862,873 RGD:6907045
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:5133242
RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:5133242
RGD:6907045
RGD:5133243
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:5133241
RGD:5133243
RGD:5133242
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:5133242
RGD:6907045
RGD:5133243
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:6907045
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:6907045
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6907045
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6907045
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:5133242
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rarb retinoic acid receptor, beta JBrowse link 15 9,915,223 10,262,599 RGD:6907045
G Rassf1 Ras association domain family member 1 JBrowse link 8 116,307,149 116,318,289 RGD:6907045
G Rassf5 Ras association domain family member 5 JBrowse link 13 47,956,754 48,022,333 RGD:6907045
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6907045
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6907045
G Rxrb retinoid X receptor beta JBrowse link 20 3,822,673 3,829,138 RGD:6907045
G Rxrg retinoid X receptor gamma JBrowse link 13 85,818,473 85,868,555 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Stk4 serine/threonine kinase 4 JBrowse link 3 160,467,552 160,546,540 RGD:6907045
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:5133242
RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwayaltered phosphatidylinositol 3-kinase-Akt signaling pathwayA phosphatidylinositol 3-kinase-Akt signaling pathway that deviates from what its normal course should be
Pathwaycisplatin drug pathwayA platinum (Pt)-containing drug
Pathwayaltered extracellular signal-regulated pathwayA Raf/Mek/Erk signaling pathway that deviates from what its normal course should be. Aberrant Raf/Mek/Erk signaling has been implicated in many types of cancer.
Pathwayaltered scatter factor/hepatocyte growth factor signaling pathwayA scatter factor/hepatocyte growth factor signaling pathway that deviates from what its normal course should be
Pathwayaltered p53 signaling pathwayaltered p53 signaling pathway
Pathwayaltered epidermal growth factor/neuregulin signaling pathwayAn epidermal growth factor/neuregulin signaling pathway that deviates from what its normal course should be.
Functional Classpotential NSCLC miRNAderegulated miRNA that could serve as early detection markers
Pathwaygefitnib drug pathwayThe pharmacokinetics and pharmacodynamics pathway of gefitinib, a selective inhibitor of Egfr

Pathway Gene Annotations

Disease Annotations Associated with Genes in the non-small cell lung cancer pathway
Disease TermsGene Symbols
Colitis, UlcerativeTp53
Pathway Annotations Associated with Genes in the non-small cell lung cancer pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
adenosine signaling pathwayAkt1 , Bad , Braf , Hras , Map2k2 , Mapk1 , Pdpk1 , Pik3ca
aldosterone signaling pathwayKras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2 , Tgfa
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered G1/S transition pathwayCdkn2a
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered p53 signaling pathwayTp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered scatter factor/hepatocyte growth factor signaling pathwayMet
Alzheimer disease pathwayBad , Casp9 , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayBad , Casp9 , Tp53
angiotensin II signaling pathwayPdpk1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg2 , Prkcb , Raf1 , Sos1 , Sos2
basal cell carcinoma pathwayTp53
bile acid transport pathwayRxra
bladder cancer pathwayBraf , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Rassf1 , Rb1 , Tp53
Bone morphogenetic proteins signaling pathwayMapk1
brain-derived neurotrophic factor signaling pathwayGrb2
calcium/calcium-mediated signaling pathwayEgfr , Erbb2 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg
cell cycle pathway, mitoticCcnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Rb1 , Tp53
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rb1 , Tgfa , Tp53
cetuximab pharmacodynamics pathwayEgfr
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcb , Raf1 , Sos1 , Sos2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rb1 , Sos1 , Sos2 , Tp53
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
cytokine mediated signaling pathwayEgf , Egfr , Met
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Egf , Egfr , Pik3ca , Pik3r1 , Plcg1
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5 , Prkca , Prkcg
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1 , Rxra , Rxrb , Rxrg
endocytosis pathwayEgf , Egfr , Hras , Met
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tp53
endothelin signaling pathwayAkt1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Prkca , Prkcg , Raf1
Entamoeba histolyca infection pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
ephrin - ephrin receptor bidirectional signaling axisGrb2 , Hras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Pik3r5 , Plcg1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1 , Sos1 , Sos2 , Tgfa
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayGrb2 , Hras , Pik3r1 , Plcg1 , Plcg2 , Sos1
FasL mediated signaling pathwayAkt1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcg , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1
fibroblast growth factor signaling pathwayAkt1 , Grb2 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1 , Plcg1 , Sos1
forkhead class A signaling pathwayAkt1
G1 phase pathwayCcnd1 , Cdk4
G1/S transition pathwayCcnd1 , Cdk4 , Cdk6 , Cdkn2a , Rb1
gefitinib pharmacodynamics pathwayEgfr
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Pten , Raf1 , Rb1 , Sos1 , Sos2 , Tgfa , Tp53
glutamate signaling pathwayMapk1 , Mapk3 , Prkca , Prkcb , Prkcg
gonadotropin-releasing hormone signaling pathwayEgfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Raf1 , Sos1 , Sos2
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1
Hedgehog signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Grb2 , Hras , Kras , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rxra , Sos1 , Sos2 , Tp53
Huntington disease pathwayCasp9 , Tp53
hypoxia inducible factor pathwayAkt1
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Casp9 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Raf1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Plcg1 , Plcg2 , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Raf1 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Bad , Grb2 , Hras , Pdpk1 , Pik3ca , Pik3r1 , Raf1 , Sos1
interleukin-1 signaling pathwayPik3ca , Pik3r1
interleukin-2 signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Prkcb , Raf1 , Sos1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1 , Sos1 , Sos2
intrinsic apoptotic pathwayBad , Casp9
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Leishmania infection pathwayMapk1 , Mapk3 , Prkcb
long term depressionBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Raf1
long term potentiationBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Raf1
measles infection pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Cdk4 , Cdk6 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tp53
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Egf , Egfr , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Raf1 , Sos1 , Sos2 , Stk4 , Tp53
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Raf1
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mapk1 , Mapk3 , Raf1
myocarditis pathwayCasp9 , Ccnd1
N-cadherin signaling pathwayPik3ca , Pik3r1 , Plcg1
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Raf1 , Sos1 , Sos2 , Tp53
NOD-like receptor signaling pathwayMapk1 , Mapk3
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Fhit , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Pten , Raf1 , Rarb , Rassf1 , Rassf5 , Rb1 , Rxra , Rxrb , Rxrg , Sos1 , Sos2 , Stk4 , Tgfa , Tp53
Notch signaling pathwayCcnd1
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1 , Prkca
nuclear factor, erythroid 2 like 2 signaling pathwayPten
p53 signaling pathwayAkt1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Pten , Rassf1 , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tgfa , Tp53
panitumumab pharmacodynamics pathwayEgfr
Parkinson disease pathwayCasp9
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Hras , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Pten
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Foxo3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1 , Pten
Plasmodium infection pathwayMet
platelet-derived growth factor signaling pathwayBraf , Grb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Prkca , Pten , Raf1 , Sos1
prion diseases pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Sos1 , Sos2 , Tgfa , Tp53
protein kinase C (PKC) signaling pathwayPdpk1 , Prkca , Prkcb , Prkcg
purine metabolic pathwayFhit
Ras family mediated signaling pathwaySos1
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
retinoic acid signaling pathwayRarb , Rxra , Rxrb , Rxrg
ribosome biogenesis pathwayPrkcb
RNA polymerase III transcription pathwayRb1
S phase pathwayCcnd1 , Cdk4
scatter factor/hepatocyte growth factor signaling pathwayGrb2 , Met , Pik3r1 , Plcg1
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , E2f1 , E2f3 , Fhit , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rarb , Rb1 , Rxra , Rxrb , Rxrg , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Mapk1 , Mapk3 , Plcg1
syndecan signaling pathwayEgfr , Hras , Mapk1 , Mapk3 , Prkca
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cdk4 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Raf1 , Sos1 , Sos2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
thyroid cancer pathwayBraf , Ccnd1 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Rxra , Rxrb , Rxrg , Tp53
titanium dioxide nanoparticle response pathwayTp53
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Trail mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayFoxo3 , Grb2 , Pdpk1 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3
trastuzumab pharmacodynamics pathwayEgfr
Trypanosoma brucei infection pathwayPrkca , Prkcb , Prkcg
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type 2 diabetes mellitus pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayCcnd1 , Prkca , Prkcb , Prkcg , Tp53
Phenotype Annotations Associated with Genes in the non-small cell lung cancer pathway

References Associated with the non-small cell lung cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: