FASL MEDIATED SIGNALING PATHWAY (PW:0000681)

View Ontology Report

Description

FasL mediated signaling is one of the major extrinsic apoptotic pathways engaging the death receptors. FasL (official symbol Faslg) and its receptor Fas, also known as CD95/APO-1, belong to the tumor necrosis superfamily (TNF) of ligands and receptors. The receptor contains an extracellular CRD (cysteine-rich domain) while the cytoplasmic part contains a DD (death domain) responsible for the interaction with adapter/effector proteins. Fas, which is ubiquitously expressed, is found at the plasma

Pathway Diagram:

Ariadne Genomics Inc. caspase targets Fadd Faslg Fas Bid Casp7 ---> caspase targets Casp7 ---> caspase targets intrinsic apoptotic pathway Cflar ---| Casp8 Casp8 Cflar clustering Fas ---- Faslg Cflar ---- Fadd Casp8 ---> Bid Casp8 --+> Bid Casp8 --+> Casp7 Casp8 ---> Casp7 Casp8 ---> Casp3 Casp8 --+> Casp3 Casp7 Casp3 Casp3 ---> caspase targets Casp3 ---> caspase targets Fadd ---- Fas Casp8 ---- Fadd
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Genes in Pathway:

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FasL mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:2314002
RGD:4143196
RGD:6484113
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6484113
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6484113
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:6484113
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:4143196
RGD:6484113
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:4143196
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:2314002
RGD:4143196
RGD:6484113
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:4143196
RGD:6484113
RGD:8662854
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6484113
G Cltc clathrin heavy chain JBrowse link 10 74,014,560 74,070,578 RGD:6484113
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:6484113
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:4143196
RGD:6484113
G Faim2 Fas apoptotic inhibitory molecule 2 JBrowse link 7 141,158,769 141,185,781 RGD:6484113
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:2314002
RGD:4143196
RGD:6484113
RGD:8662854
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:2314002
RGD:4143196
RGD:6484113
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6484113
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6484113
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6484113
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6484113
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:6484113
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6484113
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6484113
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6484113
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6484113
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6484113
G Rfc1 replication factor C subunit 1 JBrowse link 14 44,627,528 44,702,205 RGD:6484113
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:6484113
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:6484113
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6484113
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupCaspase targetscaspage target genes.
Pathwayintrinsic apoptotic pathwayintrinsic apoptotic pathway

Pathway Gene Annotations

Disease Annotations Associated with Genes in the FasL mediated signaling pathway
Disease TermsGene Symbols
46,XY Sex Reversal 6Map3k1
Abnormalities, MultipleChuk , Cltc
Acute Kidney InjuryFas
Acute Lung InjuryFadd , Fas , Faslg
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
AdenocarcinomaCasp8 , Pik3ca
Adenocarcinoma of EsophagusFas , Pik3ca
Adenocarcinoma of LungAkt1 , Pik3ca
ADENOCARCINOMA OF STOMACHAkt1 , Pik3ca
Adenocarcinoma, ProstaticAkt1 , Pik3ca
Adenomatous Polyposis ColiAkt1
Adrenocortical CarcinomaPik3ca
AgammaglobulinemiaBtk
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Alzheimer DiseaseAkt1 , Casp3 , Fas , Ikbkb , Mapk10 , Mapk14 , Mapk8 , Mapk9 , Pik3r1
Amphetamine-Related DisordersAkt1
Amyotrophic Lateral SclerosisAkt1 , Casp3 , Mapk14
AnaphylaxisBtk
Anemia, AplasticFas , Faslg
Anemia, Nonspherocytic Hemolytic, due to G6pd DeficiencyIkbkg
Angina, UnstableAkt1
AnoxiaCasp3
Anti-Glomerular Basement Membrane DiseaseMapk14 , Mapk8 , Syk
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisFas
Aortic Aneurysm, AbdominalMapk8
Aortic Aneurysm, ThoracicFas
Aortic Valve, Calcification ofAkt1
ArteriosclerosisFaslg , Mapk9
Arthritis, ExperimentalAkt1 , Btk , Faslg , Ikbkb , Ikbkg , Pik3cd
Arthritis, RheumatoidCasp7 , Fas , Faslg
Arthus ReactionBtk
AsthmaChuk , Fas
AstrocytomaAkt1
AtherosclerosisAkt1 , Faslg
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
Autism Spectrum DisorderMapk11
Autoimmune DiseasesCasp8 , Fas
Autoimmune Lymphoproliferative SyndromeCasp8 , Fas , Faslg
Autoimmune Lymphoproliferative Syndrome, Type IAFas
Bacterial InfectionsCasp3 , Casp8
Barrett EsophagusFas
Behcet SyndromeFas , Ikbkg
Biliary Tract NeoplasmsFaslg
Bipolar DisorderAkt1
Bone Diseases, DevelopmentalChuk
Brain DeathMap2k6
Brain Diseases, MetabolicFas
Brain InjuriesAkt1 , Casp3 , Casp8 , Fas
Brain IschemiaAkt1 , Casp3 , Fas , Faslg , Mapk8 , Src
Breast AdenocarcinomaAkt1 , Pik3ca
Breast Cancer, FamilialPik3r3
Breast NeoplasmsAkt1 , Birc2 , Btk , Casp3 , Casp7 , Casp8 , Fas , Faslg , Ikbkb , Map2k7 , Map3k1 , Pdpk1 , Pik3ca , Pik3r1 , Src
Bruton type agammaglobulinemiaBtk
Burkitt LymphomaPik3r1
BurnsCasp3
CalcinosisCasp3
Carbon Tetrachloride PoisoningFadd
CarcinomaEzr , Pik3r1
Carcinoma in SituAkt1
Carcinoma, Adenoid CysticPik3ca
Carcinoma, Basal CellPik3ca
Carcinoma, EndometrioidAkt1 , Pik3r2
Carcinoma, HepatocellularAkt1 , Bid , Casp8 , Pik3ca
Carcinoma, Intraductal, NoninfiltratingSrc
Carcinoma, LobularFaslg
Carcinoma, Non-Small-Cell LungAkt1 , Casp8 , Faslg , Pik3ca
Carcinoma, Pancreatic DuctalFaslg
Carcinoma, Renal CellAkt1 , Birc2 , Birc3 , Casp3 , Fas , Faslg , Pik3ca
Carcinoma, Squamous CellAkt1 , Fas , Pik3ca , Ripk1
Carcinoma, Squamous Cell of Head and NeckAkt1 , Casp8 , Pik3ca
Carcinoma, Transitional CellAkt1 , Casp3 , Fas , Faslg , Pik3ca
CardiomegalyAkt1 , Map2k6 , Mapk8 , Src
CardiomyopathiesAkt1 , Fas , Faslg , Mapk11 , Mapk14
Cardiomyopathy, DilatedFas , Faslg
Cardiomyopathy, HypertrophicCasp3
Cardiomyopathy, RestrictiveMap2k6 , Mapk14
Carotid Artery DiseasesFaslg
Carotid Artery InjuriesCflar
Carotid StenosisFaslg
CataractFas
Cell Transformation, NeoplasticMapk8
Cerebral HemorrhageCasp3 , Casp8
Ceroid Lipofuscinosis, Neuronal, 6Smpd1
Cervical Intraepithelial NeoplasiaFaslg
Chest TraumaFas
CholangiocarcinomaFaslg
CholestasisMapk14
ChorioamnionitisFas
Choroidal NeovascularizationIkbkb
Chronic Cerebral HypoperfusionMapk14
Chronic Lymphoid LeukemiaBtk
Chronic UveitisFas
Cleft PalateChuk
ClonorchiasisFas , Faslg
Cocoon SyndromeChuk
Cognition DisordersMapk14
ColitisChuk , Ikbkb , Src
Colitis, ExperimentalFas
Colonic NeoplasmsAkt1 , Fas , Ikbkb , Map2k6 , Pik3ca , Pik3r1 , Rfc1 , Src
Colorectal NeoplasmsAkt1 , Casp8 , Pik3ca , Pik3r1 , Src
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Conjunctivitis, ChronicFas
Copper-Overload CirrhosisCasp3
Corneal NeovascularizationFas
Coronary Artery DiseaseAkt1
COWDEN SYNDROME 5Pik3ca
Craniofacial AbnormalitiesFadd
CryptorchidismCasp3
Currarino TriadPik3ca
Cystic FibrosisFas , Faslg
DermatitisIkbkb
Dermatitis, Allergic ContactCasp8
Dermatitis, AtopicMapk8
Dermatitis, ContactCasp8
DermatomyositisFas
Diabetes Mellitus, ExperimentalAkt1 , Casp3 , Casp8 , Fas , Faslg , Ikbkb , Map2k6 , Pik3r1 , Smpd1
Diabetes Mellitus, Type 1Casp3 , Casp8 , Fas , Faslg
Diabetes Mellitus, Type 2Akt1 , Casp3 , Casp7 , Casp8 , Fas , Faslg , Ikbkb , Pik3r1 , Src
Diabetic AngiopathiesCasp3 , Fas , Faslg
Diabetic NephropathiesCasp3 , Fas , Faslg , Mapk14
Diabetic NeuropathiesCasp3 , Mapk14
Diabetic RetinopathyCasp3
Disease Models, AnimalAkt1 , Fas , Mapk8 , Mapk9
Drug HypersensitivityFaslg
Drug-Induced Liver InjuryCasp8 , Fadd , Fas
Dwarfism, PituitaryBtk
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Ectodermal Dysplasia, Hypohidrotic, with Immune DeficiencyIkbkg
EdemaCasp3 , Casp8 , Map2k6
Encephalomyelitis, Autoimmune, ExperimentalCasp3 , Casp8 , Faslg
Endometrial NeoplasmsPik3ca
EndophthalmitisFas
EndotoxemiaCasp3 , Casp7 , Fas , Mapk14
Enterocolitis, NecrotizingIkbkg
Epidermal NevusPik3ca
EpilepsyAkt1
Epilepsy, GeneralizedMapk10
Epileptic Encephalopathy, Lennox-Gastaut TypeMapk10
Erectile DysfunctionAkt1 , Casp3
Esophageal NeoplasmsCasp8 , Fas , Faslg , Pik3ca
Facial AsymmetryPik3ca
Fatty LiverBirc3 , Mapk8
Fetal DiseasesChuk
Fetal Growth RetardationCasp3 , Fas , Faslg
FibrosisAkt1 , Map2k7
Gallbladder NeoplasmsFaslg
Gastrointestinal NeoplasmsPik3ca
Genetic Diseases, InbornCltc , Pik3r2
GlaucomaFas
GlioblastomaAkt1 , Pik3ca , Pik3r1
GliomaFas , Pik3ca
GlomerulonephritisFas
Glucosephosphate Dehydrogenase DeficiencyIkbkg
Graft vs Host DiseaseFas , Faslg
Graves DiseaseFas
Growth DisordersPik3ca
Hamartoma Syndrome, MultipleAkt1 , Pik3ca
Hashimoto DiseaseFas
Head and Neck NeoplasmsPik3ca
Hearing Loss, SensorineuralFadd
Heart ArrestAkt1
Heart DiseasesMapk14
Heart FailureCflar , Fas , Map2k7 , Pdpk1
Heart Valve DiseasesCasp3
Hematologic DiseasesFas
HemimegalencephalyPik3ca
HepatitisFaslg
Hepatitis, ChronicCasp3
Hepatolenticular DegenerationSmpd1
Heroin DependenceFas
HIV InfectionsBirc2 , Birc3 , Fas
Hodgkin DiseaseCflar
Huntington DiseaseFas , Faslg
Hyper-IgM Immunodeficiency, X-Linked, with Ectodermal Dysplasia, HypohidroticIkbkg
HyperalgesiaMapk8 , Mapk9
HyperglycemiaCasp8
Hyperlipidemia, Familial CombinedFaslg
HyperoxiaCflar , Fadd , Fas
HyperplasiaAkt1 , Ikbkb , Pik3ca
HypersensitivityMap2k6
HypersplenismFas
HypertensionAkt1 , Casp3 , Fadd , Ikbkb , Mapk8 , Pik3r1 , Src
Hypertension, PortalPik3r1
Hypertrophy, Right VentricularAkt1
Hypogammaglobulinemia and Isolated Growth Hormone Deficiency, X-LinkedBtk
Hypogammaglobulinemia, X-LinkedBtk
HypoglycemiaPik3r1
HypothermiaFas , Faslg
Hypoxia-Ischemia, BrainCasp3 , Fas
Idiopathic Pulmonary FibrosisCflar , Fas , Faslg
Immunodeficiency 14Pik3cd
Immunodeficiency 15Ikbkb
Immunodeficiency 36Pik3r1
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
Immunologic Deficiency SyndromesBtk , Casp8
Incontinentia PigmentiIkbkg
Infarction, Middle Cerebral ArteryCasp3 , Fadd , Ikbkb
Infections, Recurrent, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsFadd
Infectious MononucleosisFas , Faslg
Infertility, MaleFas
InflammationAkt1 , Chuk
Inflammatory Bowel Disease 11Casp3
Inflammatory Bowel DiseasesIkbkb
Insulin ResistanceIkbkb , Pik3r1
Intermittent ClaudicationCasp3
Intervertebral Disc DisplacementAkt1
Intestinal DiseasesCasp3
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
Irritable Bowel SyndromeIkbkg
IschemiaMapk9
Ischemic Attack, TransientCasp3 , Fas , Ikbkb
Kashin-Beck DiseaseFas
Keratosis, SeborrheicPik3ca
Kidney NeoplasmsAkt1
Kidney Reperfusion InjuryCasp3 , Ikbkb , Src
Learning DisordersIkbkg
LeiomyomaFaslg
LeukemiaBirc2 , Birc3 , Cflar , Fadd
Leukemia, Lymphocytic, Chronic, B-CellBtk , Fas
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveFas , Faslg , Mapk14
Leukemia, Myeloid, AcuteCasp7 , Cflar , Fadd , Fas
Leukemia, Promyelocytic, AcuteAkt1
Leukemia-Lymphoma, Adult T-CellFas
Lichen PlanusRipk1
Limb Deformities, CongenitalChuk
Liver Cirrhosis, ExperimentalBirc3 , Casp7 , Ezr , Fas
Liver Failure, AcuteFas , Faslg , Mapk8
Liver NeoplasmsAkt1 , Casp8 , Mapk14 , Pik3ca
Liver Reperfusion InjuryCasp8 , Fadd , Fas , Ikbkg , Mapk8
Long QT SyndromeSyk
Lung NeoplasmsAkt1 , Casp8 , Fas , Faslg , Ikbkg , Map2k7 , Mapk14 , Pik3ca
Lung Reperfusion InjuryCasp3
Lupus Erythematosus, SystemicFas
Lymphatic MetastasisFas
Lymphoma, B-CellBtk
Lymphoma, Extranodal NK-T-CellCflar , Fas
Lymphoma, Large B-Cell, DiffuseCltc , Fas , Pdpk1 , Pik3ca , Pik3cb , Pik3cd
Lymphoma, Mantle-CellBtk , Pik3cd
Lymphoma, Non-HodgkinPik3ca
Lymphoma, T-CellAkt1
Lymphoma, T-Cell, CutaneousFas
Lymphoproliferative DisordersFas
Macular DegenerationFas
Malaria, FalciparumFas
Malformations of Cortical DevelopmentPik3ca
Mammary Neoplasms, AnimalEzr , Map2k6 , Pik3r1
Mammary Neoplasms, ExperimentalAkt1 , Casp3 , Casp7 , Casp8 , Ezr , Fas , Map2k7 , Pik3r1
Marijuana AbuseAkt1
MedulloblastomaPik3ca
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca , Pik3r2
MelanomaAkt1 , Casp8 , Fas , Faslg , Pik3ca , Pik3r1 , Syk
Melanoma, ExperimentalIkbkb
Meningeal NeoplasmsAkt1
MeningiomaAkt1
MesotheliomaSyk
Metabolic Syndrome XFadd
Microphthalmia, Syndromic 1Map3k1
Mixed Connective Tissue DiseaseFas
Mixed Tumor, MullerianPik3ca , Pik3r1
Mood DisordersAkt1
Morphine DependenceFadd
Mouth NeoplasmsPik3ca
Moyamoya DiseaseFas
Multiple MyelomaFaslg , Pik3ca
Multiple SclerosisFas , Faslg
Multiple Sclerosis, Relapsing-RemittingFas
Multiple System AtrophyFas
Multisystemic Smooth Muscle Dysfunction SyndromeFas
Muscular AtrophyAkt1 , Chuk , Ikbkb
Myasthenia GravisFas
Mycoplasma InfectionsCasp3
Myelodysplastic SyndromesCflar , Fas , Faslg
Myocardial InfarctionAkt1 , Casp3 , Map2k6
Myocardial IschemiaMapk14
Myocardial Reperfusion InjuryAkt1 , Bid , Casp3 , Casp7 , Casp8 , Cflar , Fadd , Fas , Map2k6 , Mapk14 , Mapk8 , Mapk9
Myositis, Inclusion BodyFas
Nasal PolypsFas
Nasopharyngeal CarcinomaPik3ca
Nasopharyngeal NeoplasmsPik3ca
NecrosisFas , Faslg
Nematode InfectionsPik3r1
Neoplasm InvasivenessSmpd1 , Src
Neoplasm MetastasisCasp3 , Ezr , Fadd , Fas , Faslg , Mapk9 , Src
NeoplasmsPik3ca , Pik3r1 , Src
Neoplastic Syndromes, HereditaryPik3ca
NephritisFas
Nephrosis, Puromycin AminonucleosideFas
Nerve DegenerationCasp3
Nervous System DiseasesCasp3
NeuroblastomaPik3ca
Neurotoxicity SyndromesCasp3
Niemann-Pick Disease, Intermediate, Protracted NeurovisceralSmpd1
Niemann-Pick Disease, Type ASmpd1
Niemann-Pick Disease, Type BSmpd1
Niemann-Pick DiseasesSmpd1
Non-alcoholic Fatty Liver DiseaseFas , Ikbkg
ObesityAkt1 , Fadd , Ikbkb , Pik3r1
Ocular HypertensionFas
OsteoarthritisEzr
Osteoarthritis, Temporomandibular JointFas
OsteoporosisMapk14
OsteosarcomaAkt1 , Rfc1
Ovarian Epithelial CancerPik3ca
Ovarian NeoplasmsAkt1 , Fas , Map2k6 , Map2k7 , Pik3ca , Pik3r1
Oxygen-Induced RetinopathyFas , Faslg , Mapk8
PainAkt1
Pancreatic AdenocarcinomaPik3ca
Pancreatic NeoplasmsBid , Casp8 , Cflar , Faslg
PancreatitisCasp3 , Ikbkb
Pancreatitis, Acute NecrotizingCasp3
Pancreatitis, ExperimentalIkbkg
Papillary Renal Cell Carcinoma, SporadicPik3ca
Papillomavirus InfectionsCasp8
ParaplegiaAkt1
Parkinson DiseaseAkt1 , Fas , Faslg
Parkinsonian DisordersSrc
Penile NeoplasmsPik3ca
Peripheral Vascular DiseasesFas
Pick Disease of the BrainMap2k6
Plaque, AtheroscleroticCflar
PneumoniaIkbkb
Pneumonia, BacterialChuk
Polycystic Kidney, Autosomal RecessiveAkt1 , Pik3ca , Src
Pre-EclampsiaFas
Precancerous ConditionsAkt1 , Map2k7 , Mapk8 , Mapk9
Precursor Cell Lymphoblastic Leukemia-LymphomaCasp8 , Fas
Pregnancy Complications, CardiovascularFas
Prostatic Intraepithelial NeoplasiaMap2k6 , Map2k7
Prostatic NeoplasmsAkt1 , Casp3 , Chuk , Ezr , Fas , Faslg , Map2k6 , Map2k7 , Mapk10 , Pik3ca , Pik3cd , Pik3r1 , Src
ProteinuriaFas
Proteus SyndromeAkt1
PsoriasisIkbkb
Psychoses, Substance-InducedAkt1
Pulmonary Disease, Chronic ObstructiveMapk8
Pulmonary FibrosisCflar
Purpura, Thrombocytopenic, IdiopathicFas
Radiation Injuries, ExperimentalFas
Rectal NeoplasmsPik3ca
Reperfusion InjuryAkt1 , Bid , Casp3 , Casp7 , Casp8 , Fas , Mapk8 , Mapk9 , Pik3r1 , Src
Retinal DetachmentCasp3 , Fas
Retinal DiseasesCasp3
Retinitis PigmentosaCasp7 , Ripk1
RetinoblastomaFas
Salivary Gland DiseasesCasp3
SarcomaPik3ca
SchizophreniaAkt1 , Pik3cb
Scleroderma, LimitedFas , Faslg
SeizuresFas
SeminomaFas , Faslg
SepsisCasp3 , Casp8 , Fas , Faslg
Septic PeritonitisPik3r1
SHORT SyndromePik3r1
Sjogren's SyndromeFas
Skin AbnormalitiesChuk
Skin NeoplasmsAkt1 , Casp8
Small Cell Lung CarcinomaAkt1 , Pik3ca
Smith-Magenis SyndromeCltc , Map2k6
Spinal Cord CompressionFas , Faslg
Spinal Cord InjuriesAkt1 , Casp3 , Fadd , Fas
Spinocerebellar AtaxiasCasp7
Squamous Cell Carcinoma of the LungAkt1 , Pik3ca
Status EpilepticusCasp3 , Casp8 , Src
Stomach NeoplasmsBid , Birc2 , Casp8 , Mapk8 , Pik3ca
Stomatognathic DiseasesFadd
StrokeAkt1 , Casp3 , Mapk8 , Src
Subarachnoid HemorrhageCasp3
Substance-Related DisordersFaslg
Supranuclear Palsy, ProgressiveMap2k6
Taste DisordersFas
Testicular DiseasesFaslg
Testicular InjuryFas
THROMBOCYTOPENIA 6Src
ThrombosisPik3cb
Transplant RejectionIkbkb
Trigeminal NeuralgiaMapk8 , Mapk9
Ureteral ObstructionAkt1
Urinary Bladder NeoplasmsAkt1 , Birc3 , Casp3 , Fas , Faslg , Src
Uterine Cervical NeoplasmsAkt1 , Birc2 , Casp3 , Casp8 , Faslg , Map2k6 , Pik3ca
Uterine NeoplasmsPik3ca , Pik3r1
Uveitis, Autoimmune, ExperimentalFas
VaricoceleFas
Ventilator-Induced Lung InjuryAkt1
Ventricular Dysfunction, LeftFas
VitiligoCasp7
Weight GainPik3ca
Wet Macular DegenerationMapk8
Pathway Annotations Associated with Genes in the FasL mediated signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
adenosine signaling pathwayAkt1 , Chuk , Ikbkb , Map2k6 , Map2k7 , Map3k1 , Mapk11 , Mapk8 , Pdpk1 , Pik3ca
aldosterone signaling pathwayPdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
allograft rejection pathwayFas , Faslg
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Pik3ca
altered Reelin signaling pathwaySrc
Alzheimer disease pathwayBid , Casp3 , Casp7 , Casp8 , Fadd , Fas
amyotrophic lateral sclerosis disease pathwayBid , Casp3 , Map2k6 , Mapk11 , Mapk14
angiotensin II signaling pathwayPdpk1
apoptotic cell death pathwayAkt1 , Bid , Birc2 , Birc3 , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Fadd , Fas , Faslg , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1
autoimmune thyroid disease pathwayFas , Faslg
B cell receptor signaling pathwayAkt1 , Btk , Chuk , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Syk
c-Jun N-terminal kinases MAPK signaling pathwayMap2k7 , Map3k1 , Mapk10 , Mapk8 , Mapk9
ceramide signaling pathwayAkt1 , Bid , Birc3 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Smpd1
chemokine mediated signaling pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
chronic myeloid leukemia pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
clathrin-dependent synaptic vesicle endocytosisCltc
colorectal cancer pathwayAkt1 , Casp3 , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
cytokine mediated signaling pathwayFas , Faslg
DNA replication pathwayRfc1
dopamine signaling pathwaySrc
E-cadherin signaling pathwayAkt1 , Pik3ca , Pik3r1 , Src
eicosanoid signaling pathwayAkt1 , Mapk11 , Mapk14 , Src , Syk
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwayCltc , Src
endometrial cancer pathwayAkt1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Endoplasmic Reticulum-associated degradation pathwayMap2k7 , Mapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Mapk14 , Mapk8 , Src
Entamoeba histolyca infection pathwayCasp3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
ephrin - ephrin receptor bidirectional signaling axisMapk8 , Pik3ca , Pik3r1 , Src
epidermal growth factor/neuregulin signaling pathwayAkt1 , Map2k7 , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
erythropoietin signaling pathwayBtk , Mapk14 , Mapk8 , Pik3r1
estrogen signaling pathwaySrc
extrinsic apoptotic pathwayCasp3 , Casp7 , Casp8 , Fas , Faslg
FasL mediated signaling pathwayAkt1 , Bid , Birc2 , Birc3 , Btk , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Cltc , Ezr , Fadd , Faim2 , Fas , Faslg , Ikbkb , Ikbkg , Map2k6 , Map2k7 , Map3k1 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Rfc1 , Ripk1 , Smpd1 , Src , Syk
Fc epsilon receptor mediated signaling pathwayAkt1 , Btk , Map2k6 , Map2k7 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Syk
Fc gamma receptor mediated signaling pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Syk
fibroblast growth factor signaling pathwayAkt1 , Pdpk1 , Pik3ca , Pik3r1 , Src
forkhead class A signaling pathwayAkt1
glioma pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
glutathione metabolic pathwayCasp7
glutathione synthase deficiency pathwayCasp7
glutathionuria disease pathwayCasp7
glypican signaling pathwayMapk8 , Mapk9 , Src
gonadotropin-releasing hormone signaling pathwayMap2k6 , Map2k7 , Map3k1 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Src
graft-versus-host disease pathwayFas , Faslg
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Pik3ca , Pik3r1 , Syk
Hedgehog signaling pathwayAkt1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1
Huntington disease pathwayCasp3 , Casp8 , Cltc
hypoxia inducible factor pathwayAkt1
inflammatory response pathwayMapk8
influenza A virus infection pathwayAkt1 , Fas , Faslg , Ikbkb , Map2k6 , Map2k7 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1
insulin signaling pathwayAkt1 , Ikbkb , Mapk10 , Mapk8 , Mapk9 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
insulin-like growth factor signaling pathwayAkt1 , Pdpk1 , Pik3ca , Pik3r1
interleukin-1 signaling pathwayChuk , Ikbkb , Ikbkg , Map2k6 , Mapk8 , Pik3ca , Pik3r1
interleukin-12 signaling pathwayFaslg , Map2k6 , Mapk14
interleukin-2 signaling pathwayMapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3r1 , Syk
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Mapk14 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1
intrinsic apoptotic pathwayBid , Casp3 , Casp7 , Fas
Jak-Stat signaling pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Leishmania infection pathwayMapk11 , Mapk14
measles infection pathwayAkt1 , Chuk , Fas , Faslg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
melanoma pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
mismatch repair pathwayRfc1
mitochondrial autophagy pathwaySrc
mitogen activated protein kinase signaling pathwayAkt1 , Casp3 , Chuk , Fas , Faslg , Ikbkb , Ikbkg , Map2k6 , Map2k7 , Map3k1 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9
mTOR signaling pathwayAkt1 , Ikbkb , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Mycobacterium tuberculosis infection pathwayAkt1 , Bid , Casp3 , Casp8 , Fadd , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Src , Syk
myocarditis pathwayBid , Casp3 , Casp8
N-cadherin signaling pathwayMapk8 , Pik3ca , Pik3r1
nerve growth factor signaling pathwaySrc
neurotrophic factor signaling pathwayAkt1 , Faslg , Ikbkb , Map2k7 , Map3k1 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
NOD-like receptor signaling pathwayBirc2 , Birc3 , Casp8 , Chuk , Ikbkb , Ikbkg , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9
non-small cell lung cancer pathwayAkt1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
nuclear factor kappa B signaling pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Mapk14 , Pik3ca , Pik3r1 , Src , Syk
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb
nucleotide excision repair pathwayRfc1
p38 MAPK signaling pathwayMap2k6 , Map3k1 , Mapk11 , Mapk14
p53 signaling pathwayAkt1 , Bid , Casp3 , Casp8 , Fas , Mapk14 , Mapk8 , Mapk9
pancreatic cancer pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
parathyroid hormone signaling pathwayEzr
Parkinson disease pathwayCasp3
phosphatidylinositol 3-kinase class I signaling pathwayBtk , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src , Syk
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Chuk , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
platelet-derived growth factor signaling pathwayMap2k7 , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
primary immunodeficiency disease pathwayBtk , Ikbkg
prostate cancer pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
protein kinase A (PKA) signaling pathwayEzr
protein kinase C (PKC) signaling pathwayBtk , Pdpk1
Reelin signaling pathwayAkt1 , Map2k7 , Mapk8 , Pik3ca , Pik3r1 , Src
renal cell cancer pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Ripk1
Rho/Rac/Cdc42 mediated signaling pathwayMapk8
scatter factor/hepatocyte growth factor signaling pathwayPik3r1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
small cell lung cancer pathwayAkt1 , Birc2 , Birc3 , Chuk , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
somatostatin signaling pathwaySrc
sphingolipid metabolic pathwaySmpd1
sphingosine 1-phosphate signaling pathwayAkt1 , Mapk14 , Mapk8 , Src
syndecan signaling pathwayCasp3 , Ezr , Mapk8 , Src
T cell receptor signaling pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Map2k7 , Mapk11 , Mapk14 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap3k1
titanium dioxide nanoparticle response pathwayCasp3 , Casp8 , Fas
Toll-like receptor signaling pathwayAkt1 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k6 , Map2k7 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1
Toxoplasma gondii infection pathwayAkt1 , Birc2 , Birc3 , Casp3 , Casp8 , Chuk , Ikbkb , Ikbkg , Map2k6 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Trail mediated signaling pathwayBid , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Smpd1
transforming growth factor-beta Smad dependent signaling pathwayPdpk1
Trypanosoma brucei infection pathwayFas , Faslg
Trypanosoma cruzi infection pathwayAkt1 , Casp8 , Cflar , Chuk , Fadd , Fas , Faslg , Ikbkb , Ikbkg , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
tumor necrosis factor mediated signaling pathwayBirc2 , Birc3 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k7 , Map3k1 , Ripk1 , Smpd1
type 1 diabetes mellitus pathwayFas , Faslg
type 2 diabetes mellitus pathwayIkbkb , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
type II interferon signaling pathwayAkt1 , Map3k1 , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayBirc2 , Birc3 , Map3k1 , Src
vascular endothelial growth factor signaling pathwayAkt1 , Map2k6 , Mapk11 , Mapk14 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
Wnt signaling pathwayMapk10 , Mapk8 , Mapk9
Wnt signaling, non-canonical pathwayMapk10 , Mapk8 , Mapk9
Phenotype Annotations Associated with Genes in the FasL mediated signaling pathway
Phenotype TermsGene Symbols
neurodegenerationFaslg

References Associated with the FasL mediated signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: