ALTERED INSULIN SECRETION PATHWAY (PW:0000677)

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Description

Type 2 diabetes mellitus (T2D) is reaching epidemic proportions worldwide, yet the genetic underpinnings of the disease continue to be remarkably elusive. The importance and impact of environmental factors such as diet and lifestyle on the susceptibility of the disease only add additional challenges to the identification of genetic causes. While it is known that several pathways important for the maintenance of glucose homeostasis are altered in T2D, less is known about the molecular mech

Pathway Diagram:

Elsevier Inc. ATP-sensitive K+ channels NADPH electron transport chain pathway Rab27a Cdc42 ATP ATP biosynthetic pathway oxidative phosphorylation pathway pyruvate metabolic pathway ---> pyruvate  cycling citric acid cycle pathway pyruvate metabolic pathway glycolysis pathway Gck Slc2a2 membrane depolarization --+> voltage-gated K+ channels Stx1a Munc proteins Syt proteins voltage-gated K+ channels voltage-gated Ca2+ channels Rab3a Vamp2 Snap25 Rho/Rac/Cdc42 mediated signaling pathway Rab family mediated signaling pathway voltage-gated K+ channels ---> membrane repolarization membrane depolarization citric acid cycle pathway ---> pyruvate  cycling voltage-gated Ca2+ channels ---> Ca2+ membrane repolarization glucose-6-P ---> glycolysis pathway D-glucose ---> glucose-6-P pyruvate  cycling Munc proteins ---> Stx1a Snap25 ---- voltage-gated K+ channels elevated glucose levels ---> D-glucose elevated glucose levels D-glucose glucose-6-P Ca2+ membrane depolarization --+> voltage-gated Ca2+ channels membrane repolarization ---| voltage-gated Ca2+ channels Snap25 ---| voltage-gated K+ channels
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Genes in Pathway:

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altered insulin secretion pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:2313628
G Kcnj11 potassium voltage-gated channel subfamily J member 11 JBrowse link 1 102,103,093 102,107,134 RGD:2313610
RGD:2313628

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupKATPATP-sensitive potassium channels
Gene GroupMuncsmunc (stxbp and Unc) proteins
Gene GroupVDCCvoltage-gated calcium channels
Gene GroupKcnvoltage-gated potassium channels

Pathway Gene Annotations

Disease Annotations Associated with Genes in the altered insulin secretion pathway
Pathway Annotations Associated with Genes in the altered insulin secretion pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAbcc8 , Kcnj11
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAbcc8 , Kcnj11
altered insulin secretion pathwayAbcc8 , Kcnj11
amiodarone pharmacodynamics pathwayAbcc8 , Kcnj11
amlodipine pharmacodynamics pathwayAbcc8 , Kcnj11
atenolol pharmacodynamics pathwayAbcc8 , Kcnj11
betaxolol pharmacodynamics pathwayAbcc8 , Kcnj11
bisoprolol pharmacodynamics pathwayAbcc8 , Kcnj11
bupranolol drug pathwayAbcc8 , Kcnj11
bupranolol pharmacodynamics pathwayAbcc8 , Kcnj11
carvedilol pharmacodynamics pathwayAbcc8 , Kcnj11
diabetes pathwayAbcc8
diltiazem pharmacodynamics pathwayAbcc8 , Kcnj11
disopyramide pharmacodynamics pathwayAbcc8 , Kcnj11
dobutamine pharmacodynamics pathwayAbcc8 , Kcnj11
esmolol pharmacodynamics pathwayAbcc8 , Kcnj11
flecainde pharmacodynamics pathwayAbcc8 , Kcnj11
forkhead class A signaling pathwayAbcc8 , Kcnj11
fosphenytoin pharmacodynamics pathwayAbcc8 , Kcnj11
gliclazide pharmacodynamics pathwayAbcc8
glyburide pharmacodynamics pathwayAbcc8
ibutilide pharmacodynamics pathwayAbcc8 , Kcnj11
insulin secretion pathwayAbcc8 , Kcnj11
isoprenaline pharmacodynamics pathwayAbcc8 , Kcnj11
isradipine pharmacodynamics pathwayAbcc8 , Kcnj11
levobunolol pharmacodynamics pathwayAbcc8 , Kcnj11
lidocaine pharmacodynamics pathwayAbcc8 , Kcnj11
metoprolol pharmacodynamics pathwayAbcc8 , Kcnj11
mexiletine pharmacodynamics pathwayAbcc8 , Kcnj11
nadolol pharmacodynamics pathwayAbcc8 , Kcnj11
nebivolol pharmacodynamics pathwayAbcc8 , Kcnj11
nifedipine pharmacodynamics pathwayAbcc8 , Kcnj11
nimodipine pharmacodynamics pathwayAbcc8 , Kcnj11
nisoldipine pharmacodynamics pathwayAbcc8 , Kcnj11
nitrendipine pharmacodynamics pathwayAbcc8 , Kcnj11
penbutolol pharmacodynamics pathwayAbcc8 , Kcnj11
phenytoin pharmacodynamics pathwayAbcc8 , Kcnj11
pindolol pharmacodynamics pathwayAbcc8 , Kcnj11
potassium channel inhibitors pharmacodynamics pathwayAbcc8
procainamide pharmacodynamics pathwayAbcc8 , Kcnj11
propranolol pharmacodynamics pathwayAbcc8 , Kcnj11
quinidine pharmacodynamics pathwayAbcc8 , Kcnj11
sotalol pharmacodynamics pathwayAbcc8 , Kcnj11
timolol pharmacodynamics pathwayAbcc8 , Kcnj11
type 2 diabetes mellitus pathwayAbcc8 , Kcnj11
verapamil pharmacodynamics pathwayAbcc8 , Kcnj11

References Associated with the altered insulin secretion pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: