GLUCAGON SIGNALING PATHWAY (PW:0000676)

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Description

In the pancreatic alpha cells of the islets of Langerhans, glucagon is processed from the precursor proglucagon by the prohormone convertase 2 (PC-2). In the intestinal L cells and brainstem neurons, prohormone convertase 1 (PC-1) processes the same precursor molecule into several peptides distinct from glucagon, including the glucagon-like peptides (GLP) 1 and 2. The resulting peptides bind to cognate G-protein coupled receptors (GPCR) to elicit distinct responses. When the levels of circulatin

Pathway Diagram:

Ariadne Genomics Inc. expression of gluconeogenic genes gluconeogenesis pathway glycogen degradation pathway glycogen biosynthetic pathway glycolysis pathway protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphas family Adcy6 Adcy5 protein kinase A (PKA) signaling pathway --+> expression of gluconeogenic genes reduced F2, 6P levels protein kinase A (PKA) signaling pathway --+> gluconeogenesis pathway protein kinase A (PKA) signaling pathway ---| glycolysis pathway ATP ---> cAMP Gnas --+> Adcy6 Gnas --+> Adcy5 cAMP --+> protein kinase A (PKA) signaling pathway cAMP ATP Gnas Gcg Gcgr ---- Gnas Gcg ---- Gcgr protein kinase A (PKA) signaling pathway --+> glycogen degradation pathway protein kinase A (PKA) signaling pathway ---| glycogen biosynthetic pathway Gcgr
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Genes in Pathway:

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glucagon signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcy5 adenylate cyclase 5 JBrowse link 11 68,695,839 68,842,452 RGD:2315004
RGD:2315006
G Adcy6 adenylate cyclase 6 JBrowse link 7 140,270,678 140,291,722 RGD:2315004
RGD:2315006
G Gcg glucagon JBrowse link 3 48,442,635 48,451,650 RGD:2315015
G Gcgr glucagon receptor JBrowse link 10 109,707,863 109,716,253 RGD:1625210
RGD:2315004
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:1625210
RGD:2315004

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwaygluconeogenesis pathway
Pathwayglycogen biosynthetic pathway
Pathwayglycolysis pathway
Pathwayglycogen degradation pathway
PathwayG protein mediated signaling via Galphas familyBased on sequence similarity, the Galpha genes have been grouped into four classes. Effectors of activated Galphas are adenylyl cyclases that catalyzed the formation of cAMP
Small MoleculecAMPcAMP binding to the PKA complex leads to dissociation of the catalytic subunits
Pathwayprotein kinase A (PKA) signaling pathwayProtein kinase A (PKA) signaling is a widely used intracellular pathway and the major route for channeling the second messenger cAMP signal

Pathway Gene Annotations

Disease Annotations Associated with Genes in the glucagon signaling pathway
Disease TermsGene Symbols
Aberrant Crypt FociGcg
Abnormalities, MultipleAdcy5 , Gnas
AcromegalyGnas
Acth-Independent Macronodular Adrenal HyperplasiaGcgr , Gnas
ACTH-Secreting Pituitary AdenomaGnas
Adenocarcinoma of LungGnas
ADENOCARCINOMA OF STOMACHGnas
Adrenal Gland NeoplasmsGnas
Adrenocortical CarcinomaGnas
Albright's Hereditary OsteodystrophyGnas
Alzheimer DiseaseGcg , Gnas
Birth WeightAdcy5
Bone Diseases, MetabolicGnas
BrachydactylyGnas
BradycardiaGcg
Breast NeoplasmsGnas
Cafe-au-Lait SpotsGnas
CarcinomaAdcy5
Carcinoma, HepatocellularGnas
Carcinoma, Squamous Cell of Head and NeckGnas
CardiomyopathiesAdcy5
CatalepsyGcg
CholangiocarcinomaGnas
Cognition DisordersGnas
ColitisGcg
Colonic NeoplasmsGcg
Colorectal NeoplasmsGnas
ComaGcg
ConstipationGcg
Cushing SyndromeGnas
Diabetes Mellitus, ExperimentalGcg
Diabetes Mellitus, Type 2Adcy5 , Gcg , Gcgr
DysarthriaAdcy5
Dyskinesia, Familial, with Facial MyokymiaAdcy5
Endocrine System DiseasesGnas
FibrosisAdcy5
Fibrous Dysplasia, PolyostoticGnas
GallstonesGnas
Genetic Diseases, InbornAdcy5 , Gnas
Growth Hormone-Secreting Pituitary AdenomaGnas
Heart DiseasesGcg
Heart FailureGcg
Hemorrhagic DisordersGnas
HyperglycemiaGcg
HyperinsulinismGcg
HyperkinesisGcg
HyperlipidemiasGcg
HypertensionAdcy5 , Gcg , Gnas
HypocalcemiaGnas
HypotensionGcg
Hypotension, OrthostaticGnas
HypothermiaGcg
HypoxiaGnas
Insulin ResistanceGnas
Intellectual DisabilityGnas
LETHAL CONGENITAL CONTRACTURE SYNDROME 8Adcy6
Leukemia, Lymphocytic, Chronic, B-CellGnas
liver cancerGnas
Liver Diseases, ParasiticGnas
Liver NeoplasmsGnas
Mammary Neoplasms, AnimalAdcy5
Mammary Neoplasms, ExperimentalAdcy5
MelanomaGnas
Myocardial Reperfusion InjuryGcg
NeoplasmsGnas
NeuroblastomaGnas
Neurodevelopmental DisordersAdcy5
ObesityGcg , Gnas
Osseous Heteroplasia, ProgressiveGnas
Ossification, HeterotopicGnas
OsteoporosisAdcy5
Pancreatic AdenocarcinomaGnas
Pancreatic NeoplasmsGnas
Parkinsonian DisordersAdcy5
Pituitary ACTH HypersecretionGnas
Pituitary NeoplasmsGnas
PoisoningGcg
Polycystic Ovary SyndromeGnas
Prediabetic StateGcg
Prolonged Bleeding Time, Brachydactyly, and Mental RetardationGnas
PseudohypoaldosteronismGnas
PseudohypoparathyroidismGnas
Pseudohypoparathyroidism Type 1AGnas
Pseudohypoparathyroidism Type 1BGnas
Pseudohypoparathyroidism Type 1CGnas
PseudopseudohypoparathyroidismGnas
Puberty, PrecociousGnas
Respiration DisordersGnas
Sex Cord-Gonadal Stromal TumorsGnas
Smith-Magenis SyndromeGcgr
SpasmGcg
Stomach DiseasesGcg
Substance Withdrawal SyndromeGnas
TachycardiaGcg , Gnas
Tachycardia, SinusGcg
TetanyGnas
Uterine Cervical NeoplasmsGnas
Vascular DiseasesGcg
Ventricular Dysfunction, LeftAdcy5
Pathway Annotations Associated with Genes in the glucagon signaling pathway
Pathway TermsGene Symbols
adenosine signaling pathwayGnas
bile acid transport pathwayAdcy5 , Adcy6 , Gnas
calcium/calcium-mediated signaling pathwayGnas
chemokine mediated signaling pathwayAdcy5 , Adcy6
corticotropin-releasing hormone signaling pathwayGnas
dilated cardiomyopathy pathwayAdcy5 , Adcy6 , Gnas
dopamine signaling pathway via D1 family of receptorsAdcy5 , Gnas
dopamine signaling pathway via D2 family of receptorsAdcy5
endothelin signaling pathwayAdcy5 , Adcy6
Entamoeba histolyca infection pathwayGnas
epinephrine signaling pathway via adrenergic receptor betaGnas
follicle-stimulating hormone signaling pathwayGnas
forkhead class A signaling pathwayGcg
G protein mediated signaling pathway via Galphai familyAdcy5
G protein mediated signaling pathway via Galphas familyAdcy5 , Adcy6 , Gcgr , Gnas
glucagon signaling pathwayAdcy5 , Adcy6 , Gcg , Gcgr , Gnas
glutamate signaling pathwayAdcy5 , Adcy6 , Gnas
gonadotropin-releasing hormone signaling pathwayAdcy5 , Adcy6 , Gnas
histamine signaling pathway, immunologicalGnas
long term depressionGnas
luteinizing hormone signaling pathwayGnas
melanocortin system pathwayGnas
prostaglandin D2 signaling pathwayGnas
prostaglandin I2 signaling pathwayGnas
protein kinase A (PKA) signaling pathwayAdcy5 , Adcy6
purine metabolic pathwayAdcy5 , Adcy6
serotonin signaling pathway via receptors engaging G alphas protein familyGnas
Trypanosoma cruzi infection pathwayGnas
vasopressin signaling pathwayAdcy6 , Gnas
vasopressin signaling pathway via receptor type 2Adcy6 , Gnas

References Associated with the glucagon signaling pathway:

Ontology Path Diagram:

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