ALTERED TRANSFORMING GROWTH FACTOR-BETA SMAD DEPENDENT SIGNALING PATHWAY (PW:0000614)

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Description

Transforming growth factor-beta superfamily mediated pathways are central regulators of proliferation and survival, migration and differentiation, angiogenesis, embryonic development and wound healing. The transforming growth factor-beta (Tgf-b) Smad-dependent pathway is one of the best characterized modules of the Tgf-b superfamily signaling. Deregulation of the Tgf-b Smad dependent signaling renders the otherwise tumor suppressive and growth inhibitory pathway, a pro-growth and pro-tumo

Pathway Diagram:

Ariadne Genomics Inc. Tgf-beta target genes Transcription factors/co-activators colorectal cancer pathway Colorectal Neoplasms Pancreatic Neoplasms Prostatic Neoplasms Smad7 Smurf2 Tgf-beta target genes ---> Colorectal Neoplasms Smad3 Smad2 Smad7 ---| Tgfbr1 Fkbp1a Zfyve9 Dcn A2m Tgfbr3 Smad3 ---- Zfyve9 Fkbp1a ---| Tgfbr1 A2m ---| Tgfb1 Smad7 ---| Tgfbr1 Smad2 ---- Zfyve9 Tgfbr1 ---- Zfyve9 Tgfb1 ---- Tgfbr3 Dcn ---| Tgfb1 Tgf-beta target genes ---> Smad7 Smurf1 Smad4 Tgf-beta target genes ---> colorectal cancer pathway Tgf-beta target genes ---> Pancreatic Neoplasms Translocated Smad ---> Tgf-beta target genes Tgfbr2 Tgfb1 ---- Tgfbr2 Tgfb1 Tgfbr1 Tgfb1 ---- Tgfbr1 Tgf-beta target genes ---> Prostatic Neoplasms Translocated Smad
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Genes in Pathway:

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altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:2306282
RGD:2308865
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:2306282
RGD:5490966
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:2306282
RGD:5490965
RGD:5490966
RGD:2308865
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:2308865
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2299005
RGD:2306282
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:2299005
RGD:2306282
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:2299005
RGD:2306282
RGD:2308865
RGD:5490966
RGD:5490965

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwaycolorectal cancer pathwayColorectal cancer are malignant tumors of the colon and rectum
Gene GroupTgf-beta target genestransforming growth factor, beta target genes

Pathway Gene Annotations

Disease Annotations Associated with Genes in the altered transforming growth factor-beta Smad dependent signaling pathway
Disease TermsGene Symbols
Abortion, SpontaneousTgfb1 , Tgfbr1
Acro-OsteolysisSmad4
Acromicric dysplasiaSmad2 , Tgfb1
Acute Kidney InjuryTgfb1
Acute Lung InjuryTgfb1
AdenocarcinomaTgfb1
Adenocarcinoma of EsophagusSmad4
Adenocarcinoma of LungSmad4
ADENOCARCINOMA OF STOMACHSmad4
Adenocarcinoma, ColonTgfb1
Adenocarcinoma, ProstaticSmad4
Anemia, AplasticTgfb1
Anemia, Sickle CellTgfb1
AnetodermaTgfb1
AneurysmSmad3 , Tgfbr2
Aneurysm, DissectingSmad3 , Tgfbr1 , Tgfbr2
Aortic AneurysmSmad3 , Tgfbr1 , Tgfbr2
Aortic Aneurysm, Familial Thoracic 1Tgfbr2
Aortic Aneurysm, Familial Thoracic 3Tgfbr2
Aortic Aneurysm, ThoracicSmad3 , Tgfbr1 , Tgfbr2
Aortic DiseasesSmad4
Aortic Valve InsufficiencyTgfb1
ArteriosclerosisTgfb1 , Tgfbr2
Arthritis, ExperimentalTgfbr2
Arthritis, JuvenileSmad3
AsthmaTgfb1
Asthma, OccupationalTgfb1
Behcet SyndromeTgfb1
BerylliosisTgfb1
Bone DiseasesTgfbr2
Bone NeoplasmsTgfbr2
BrachydactylySmad4
Brain IschemiaTgfb1
breast cancerSmad4
Breast NeoplasmsSmad2 , Smad4 , Tgfb1
CachexiaTgfb1
CalcinosisTgfb1
Camurati-Engelmann SyndromeTgfb1
CarcinomaTgfb1 , Tgfbr2
Carcinoma, Ductal, BreastSmad4
Carcinoma, HepatocellularSmad2 , Smad4 , Tgfb1 , Tgfbr2
Carcinoma, Pancreatic DuctalTgfb1 , Tgfbr2
Carcinoma, Renal CellSmad2 , Smad4
Carcinoma, Squamous CellTgfb1
Carcinoma, Squamous Cell of Head and NeckSmad4
Carcinoma, Transitional CellSmad4
CarcinosarcomaTgfb1
Cardiac FibrosisTgfb1
CardiomegalyTgfb1
Cardiomyopathy, HypertrophicTgfb1
Carotid Artery DiseasesTgfb1
Cell Transformation, NeoplasticTgfb1
CholangiocarcinomaSmad4 , Tgfb1 , Tgfbr2
ChorioamnionitisTgfb1
CicatrixSmad4
Cleft PalateTgfb1
Cognition DisordersSmad4
Colitis, ExperimentalSmad4
colon carcinomaTgfb1
Colonic NeoplasmsTgfbr2
colorectal cancerTgfb1
Colorectal Cancer, Hereditary Nonpolyposis, Type 6Tgfbr2
Colorectal NeoplasmsSmad4 , Smad7 , Tgfb1 , Tgfbr1
Colorectal Neoplasms, Hereditary NonpolyposisSmad2 , Smad3 , Smad4 , Tgfbr1 , Tgfbr2
Conjunctivitis, AllergicTgfb1
Copper-Overload CirrhosisSmad2 , Tgfb1
Coronary Artery DiseaseTgfb1
Craniofacial AbnormalitiesSmad2 , Smad3 , Smad4 , Tgfbr2
Crohn DiseaseSmad3
Cystic FibrosisTgfb1
DeafnessSmad4
Dermatitis, AtopicTgfb1
Diabetes Mellitus, ExperimentalTgfb1
Diabetes Mellitus, Type 1Tgfb1
Diabetes Mellitus, Type 2Smad4 , Tgfb1 , Tgfbr2
Diabetic NephropathiesTgfb1 , Tgfbr2
Diabetic NeuropathiesTgfb1
Diaphyseal Dysplasia 1, ProgressiveTgfb1
Dilatation, PathologicTgfb1
Dry Eye SyndromesTgfb1
Duodenal UlcerTgfb1
Ehlers-Danlos SyndromeTgfb1
Encephalomyelitis, Autoimmune, ExperimentalTgfb1
Endometrial NeoplasmsSmad2 , Smad3 , Smad4 , Smad7
Endomyocardial FibrosisTgfb1
Eosinophilic EsophagitisTgfb1
Erectile DysfunctionTgfb1
esophageal cancerTgfbr2
Esophageal NeoplasmsSmad4 , Tgfbr2
Eye AbnormalitiesTgfbr2
Familial Primary Pulmonary HypertensionSmad4
FatigueTgfbr2
FibrosisTgfb1
Fractures, BoneTgfbr2
Gallbladder NeoplasmsTgfb1
Gastrointestinal NeoplasmsSmad4
Gastrointestinal Stromal TumorsTgfbr2
Genetic Diseases, InbornSmad2
Genital Diseases, FemaleSmad2
Glomerulonephritis, IGATgfb1
Glomerulonephritis, MembranoproliferativeTgfbr2
Glomerulosclerosis, Focal SegmentalTgfb1
Growth Mental Deficiency Syndrome of MyhreSmad4
Heart DiseasesTgfb1
Hemophilia ATgfb1
Hepatitis, AutoimmuneTgfb1
Hepatitis, ChronicSmad2 , Tgfb1
Hernia, DiaphragmaticTgfb1
Hernia, InguinalTgfbr2
HyperlipidemiasTgfb1
HyperoxiaTgfb1
HyperplasiaTgfb1 , Tgfbr2
HypersensitivityTgfb1
HypertensionTgfb1
Hypertension, PulmonarySmad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
Hypertrophy, Right VentricularTgfb1
Hypoglossal Nerve InjuriesSmad2 , Smad3 , Smad4 , Smad7
Impotence, VasculogenicTgfbr2
InflammationTgfb1
InsulinomaTgfb1
Intervertebral Disc DegenerationTgfb1
Intestinal PolyposisSmad4
Juvenile Polyposis SyndromeSmad4
Juvenile Polyposis with Hereditary Hemorrhagic TelangiectasiaSmad4
Keratoacanthoma FamilialTgfbr1
Keratosis, ActinicTgfb1
Kidney DiseasesTgfb1 , Tgfbr1 , Tgfbr2
Kidney Failure, ChronicTgfb1
Laryngotracheal Stenosis, Progressive, with Short Stature and ArthropathySmad4
LeiomyomaSmad3 , Tgfbr1
Liver CirrhosisSmad3 , Tgfb1
Liver Cirrhosis, AlcoholicSmad3 , Tgfb1
Liver Cirrhosis, ExperimentalSmad2 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
Liver Diseases, ParasiticSmad4
Liver Neoplasms, ExperimentalTgfb1
Loeys-Dietz SyndromeSmad3 , Tgfbr1 , Tgfbr2
LOEYS-DIETZ SYNDROME 2Tgfbr2
Loeys-Dietz Syndrome 3Smad3
Loeys-Dietz Syndrome, Type 1bTgfbr2
Lung DiseasesTgfb1
Lung Diseases, InterstitialTgfb1
Lung NeoplasmsTgfb1 , Tgfbr2
Lymphatic MetastasisSmad4
Mammary Neoplasms, ExperimentalTgfb1 , Tgfbr1 , Tgfbr2
Marfan SyndromeTgfbr2
Metabolic Syndrome XTgfb1
Microphthalmia, Cataracts, and Iris AbnormalitiesSmad4
Microsatellite InstabilityTgfbr2
Migraine DisordersTgfbr2
Multiple MyelomaTgfb1
Muscular DiseasesSmad4 , Tgfb1
Muscular Dystrophy, DuchenneTgfb1
Myocardial InfarctionSmad2 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
Myocardial Reperfusion InjurySmad3 , Smad4 , Tgfb1
Nasal PolypsTgfb1
Neoplasm InvasivenessTgfb1
Neoplasm MetastasisTgfb1 , Tgfbr1 , Tgfbr2
Neoplastic Syndromes, HereditarySmad4
NephritisSmad7
Nephrolithiasis, Calcium OxalateTgfb1
Nephrotic SyndromeTgfb1
NeuralgiaTgfb1
Non-alcoholic Fatty Liver DiseaseTgfb1
ObesityTgfb1
Occupational DiseasesTgfb1
Odontogenic CystsSmad4
Oral Submucous FibrosisTgfb1
Ossification, HeterotopicSmad4
OsteoarthritisSmad3
OsteochondrodysplasiasTgfb1 , Tgfbr1
OsteoporosisTgfb1
Osteoporosis, PostmenopausalTgfb1
Ovarian NeoplasmsSmad2 , Smad4 , Smad7
Pancreatic AdenocarcinomaSmad4
pancreatic carcinoma Smad4
Pancreatic NeoplasmsSmad3 , Smad4 , Tgfb1 , Tgfbr2
PapillomaTgfb1
Paraquat LungSmad7 , Tgfb1
Penile IndurationTgfb1
Peritoneal FibrosisTgfb1
Pleural DiseasesTgfb1
PneumoniaTgfb1
Precancerous ConditionsSmad3 , Smad4
Primary MyelofibrosisTgfb1
Prostatic Intraepithelial NeoplasiaSmad4
Prostatic NeoplasmsSmad3 , Smad4 , Tgfb1 , Tgfbr2
ProstatitisSmad4
ProteinuriaTgfb1
PsoriasisTgfb1
Pulmonary Disease, Chronic ObstructiveSmad4 , Tgfb1
Pulmonary EmphysemaTgfb1
Pulmonary FibrosisSmad4 , Smad7 , Tgfb1 , Tgfbr2
Purpura, Thrombocytopenic, IdiopathicTgfb1
Radiation InjuriesTgfbr2
Radiation PneumonitisTgfb1
Reperfusion InjuryTgfbr2
RhinitisTgfb1
SarcoidosisTgfb1
Sarcoidosis, PulmonaryTgfb1
Scleroderma, LocalizedTgfb1
SeminomaSmad4
SepsisTgfb1
Sjogren's SyndromeTgfb1
Skin NeoplasmsTgfb1 , Tgfbr1
Spinal Cord InjuriesTgfb1
Stomach NeoplasmsSmad4
StrokeTgfb1
Telangiectasia, Hereditary HemorrhagicSmad4
Telangiectasia, Hereditary Hemorrhagic, Type 1Tgfb1
Thrombocythemia, EssentialTgfb1
ThrombocytopeniaTgfb1
Tracheal StenosisTgfb1
Tubulointerstitial FibrosisTgfb1
Tumor Predisposition SyndromeSmad4
UremiaTgfb1 , Tgfbr1
Ureteral ObstructionTgfb1
Urethral ObstructionTgfb1
Urinary Bladder NeoplasmsSmad2 , Smad4 , Tgfbr1
UrticariaTgfb1
Uterine Cervical NeoplasmsSmad2 , Smad4
Uterine NeoplasmsSmad3
UveitisTgfb1
Ventricular RemodelingSmad2 , Smad3 , Tgfb1
VitiligoTgfb1
Wallerian DegenerationTgfb1
Wounds and InjuriesTgfb1
Pathway Annotations Associated with Genes in the altered transforming growth factor-beta Smad dependent signaling pathway
Pathway TermsGene Symbols
activin signaling pathwaySmad2 , Smad3
altered transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
Bone morphogenetic proteins signaling pathwaySmad4 , Smad7
cell cycle pathway, mitoticSmad2 , Smad3 , Smad4 , Tgfb1
ceramide signaling pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
chronic myeloid leukemia pathwaySmad3 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
colorectal cancer pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
cytokine mediated signaling pathwayTgfb1 , Tgfbr1 , Tgfbr2
dilated cardiomyopathy pathwayTgfb1
endocytosis pathwaySmad2 , Smad3 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
Entamoeba histolyca infection pathwayTgfb1
glypican signaling pathwaySmad2 , Tgfb1 , Tgfbr2
hypertrophic cardiomyopathy pathwayTgfb1
hypoxia inducible factor pathwaySmad3 , Smad4
interleukin-27 signaling pathwayTgfb1
Leishmania infection pathwayTgfb1
mitogen activated protein kinase signaling pathwayTgfb1 , Tgfbr1 , Tgfbr2
Mycobacterium tuberculosis infection pathwayTgfb1
pancreatic cancer pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
Plasmodium infection pathwayTgfb1
renal cell cancer pathwayTgfb1
rheumatoid arthritis disease pathwayTgfb1
syndecan signaling pathwayTgfb1
Toxoplasma gondii infection pathwayTgfb1
transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
transforming growth factor-beta superfamily mediated signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
Trypanosoma cruzi infection pathwaySmad2 , Smad3 , Tgfb1 , Tgfbr1 , Tgfbr2
type II interferon signaling pathwaySmad7
Wnt signaling pathwaySmad2 , Smad3 , Smad4
Phenotype Annotations Associated with Genes in the altered transforming growth factor-beta Smad dependent signaling pathway
Phenotype TermsGene Symbols
liver fibrosisSmad3

References Associated with the altered transforming growth factor-beta Smad dependent signaling pathway:

Ontology Path Diagram:

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