COLORECTAL CANCER PATHWAY (PW:0000612)

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Description

Colorectal cancer (CRC) affects both men and women and is a rather prevalent condition in the Western world. A number of pathways are known to be altered in CRC; they include the canonical Wnt, transforming growth factor-beta, Smad dependent and the extracellular signal-regulated Raf/Mek/Erk signaling pathways and the regulatory DNA mismatch repair pathway. While mutations in components of some of these pathways may be implicated in other forms of cancer and/or types of diseases, the diagram dep

Pathway Diagram:

Elsevier Inc. cisplatin_DNA_adducts ---| Colorectal Neoplasms Axin2 Ctnnb1 Axin1 Apc altered Wnt signaling, canonical pathway Tgfbr2 Tgfbr1 Tgfb1 Smad3 Smad4 Smad2 altered transforming growth factor-beta Smad dependent signaling pathway upregulated miRNA ---> downregulated target translation upregulated target translation downregulated target translation cisplatin_DNA_adducts abnormal Watson-Crick pairing Mlh1 Msh2 Msh6 Pms1 Pms2 altered mismatch repair pathway altered expression of target genes potential CRC miRNA ---> Colorectal Neoplasms downregulated miRNA ---> upregulated target translation cisplatin drug pathway Braf Kras altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered mismatch repair pathway ---> abnormal Watson-Crick pairing altered Wnt signaling, canonical pathway ---> altered expression of target genes altered transforming growth factor-beta Smad dependent signaling pathway ---> altered expression of target genes altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes potential CRC miRNA upregulated miRNA downregulated miRNA cisplatin drug pathway ---> cisplatin_DNA_adducts Colorectal Neoplasms
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Genes in Pathway:

show annotations for term's descendants       view all columns
colorectal cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Apc APC, WNT signaling pathway regulator JBrowse link 18 27,011,710 27,106,323 RGD:2293188
RGD:6907045
G Apc2 APC2, WNT signaling pathway regulator JBrowse link 7 12,258,468 12,280,459 RGD:6907045
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 JBrowse link 16 2,560,103 2,602,035 RGD:6907045
G Axin1 axin 1 RGD:2293188
RGD:6907045
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:2293188
RGD:6907045
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6907045
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6907045
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:2298531
RGD:6907045
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:2293188
RGD:6907045
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6907045
G Cyct cytochrome c, testis JBrowse link 3 63,204,779 63,211,847 RGD:6907045
G Dcc DCC netrin 1 receptor JBrowse link 18 66,518,213 67,629,801 RGD:6907045
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6907045
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:2306732
RGD:6907045
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:2306714
RGD:6907045
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:2306714
RGD:6907045
G Msh3 mutS homolog 3 JBrowse link 2 21,790,048 21,931,791 RGD:6907045
G Msh6 mutS homolog 6 JBrowse link 6 11,644,565 11,662,389 RGD:2306714
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pms1 PMS1 homolog 1, mismatch repair system component JBrowse link 9 53,120,656 53,206,520 RGD:2306714
G Pms2 PMS1 homolog 2, mismatch repair system component JBrowse link 12 12,714,394 12,738,654 RGD:2306714
G Rac1 ras-related C3 botulinum toxin substrate 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Rac2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) JBrowse link 7 119,769,708 119,797,111 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Ralgds ral guanine nucleotide dissociation stimulator JBrowse link 3 7,090,134 7,130,548 RGD:6907045
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6907045
G RSA-14-44 RSA-14-44 protein JBrowse link 4 96,831,880 96,833,252 RGD:6907045
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:2306282
RGD:2308865
RGD:6907045
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:2306282
RGD:6907045
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:2306282
RGD:2308865
RGD:6907045
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:2308865
G Tcf3 transcription factor 3 JBrowse link 7 12,146,642 12,168,400 RGD:6907045
G Tcf7 transcription factor 7 JBrowse link 10 37,616,033 37,646,027 RGD:6907045
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:6907045
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2306282
RGD:6907045
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6907045
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:6907045
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:2306282
RGD:6907045
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:2306282
RGD:2308865
RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Grouppotential CRC mRNApotential CRC mRNA

Pathway Gene Annotations

Disease Annotations Associated with Genes in the colorectal cancer pathway
Disease TermsGene Symbols
Aberrant Crypt FociApc , Ctnnb1
Abnormalities, Drug-InducedRhoa
Abnormalities, MultipleCtnnb1 , Gsk3b , Kras , Mapk1 , Smad2
Abortion, SpontaneousTgfb1 , Tgfbr1
Acro-OsteolysisSmad4
Acromicric DysplasiaSmad2 , Tgfb1
Acute Kidney InjuryBad , Bax , Bcl2 , Gsk3b , Myc , Tgfb1 , Tp53
Acute Lung InjuryBax , Bcl2 , Tgfb1
AdenocarcinomaApc , Bcl2 , Birc5 , Ccnd1 , Ctnnb1 , Kras , Myc , Pik3ca , Tcf7l2 , Tgfb1 , Tp53
Adenocarcinoma of EsophagusPik3ca , Smad4 , Tp53
Adenocarcinoma of LungAkt1 , Apc , Braf , Ctnnb1 , Kras , Map2k1 , Mlh1 , Msh3 , Msh6 , Myc , Pik3ca , Raf1 , Rhoa , Smad4 , Tp53
ADENOCARCINOMA OF STOMACHAkt1 , Braf , Ctnnb1 , Kras , Map2k1 , Mlh1 , Pik3ca , Raf1 , Rhoa , Smad4 , Tp53
Adenocarcinoma, Bronchiolo-AlveolarKras , Tp53
Adenocarcinoma, Clear CellBcl2 , Tp53
Adenocarcinoma, FollicularKras
Adenocarcinoma, ProstaticAkt1 , Braf , Ctnnb1 , Map2k1 , Pik3ca , Smad4 , Tp53
AdenomaApc , Bcl2 , Ctnnb1 , Kras , Tp53
Adenoma, ColorectalApc
Adenoma, Liver CellCtnnb1 , Kras
Adenomatous Polyposis ColiAkt1 , Apc
Adenomatous Polyposis Coli, AttenuatedApc
Adenomatous PolypsApc
Adrenal Gland NeoplasmsCtnnb1 , Tp53
Adrenal InsufficiencyBax , Bcl2
Adrenocortical CarcinomaBraf , Ctnnb1 , Pik3ca , Tp53
Adrenocortical Carcinoma, HereditaryTp53
Adrenocortical Carcinoma, PediatricTp53
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AGAMMAGLOBULINEMIA 8, AUTOSOMAL DOMINANTTcf3
Agenesis of Corpus CallosumDcc
Aging, PrematureBax , Bcl2 , Tp53
AIDS-related Kaposi SarcomaBcl2
Alzheimer DiseaseAkt1 , Apc , Bad , Bax , Bcl2 , Casp3 , Ctnnb1 , Gsk3b , Mapk10 , Mapk8 , Mapk9 , Pik3r1 , Tp53
AmeloblastomaBraf
Amphetamine-Related DisordersAkt1 , Fos
Amyotrophic Lateral SclerosisAkt1 , Casp3 , Casp9 , Gsk3b , Tp53
Amyotrophic Lateral Sclerosis 1Fos
AnemiaKras
Anemia, AplasticTgfb1
Anemia, MacrocyticApc
Anemia, RefractoryBirc5
Anemia, Refractory, with Excess of BlastsBirc5
Anemia, Sickle CellTgfb1
AnetodermaTgfb1
AneurysmSmad3 , Tgfbr2
Aneurysm, DissectingSmad3 , Tgfbr1 , Tgfbr2
Angina, UnstableAkt1
AnodontiaAxin2
AnoxiaCasp3
Anti-Glomerular Basement Membrane DiseaseMapk8
Anxiety DisordersFos
Aortic AneurysmSmad3 , Tgfbr1 , Tgfbr2
Aortic Aneurysm, AbdominalMapk8
Aortic Aneurysm, Familial Thoracic 1Tgfbr2
Aortic Aneurysm, Familial Thoracic 3Tgfbr2
Aortic Aneurysm, ThoracicSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
Aortic DiseasesSmad4
Aortic Valve InsufficiencyTgfb1 , Tgfb2
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arrhythmogenic Right Ventricular DysplasiaTgfb3
Arrhythmogenic Right Ventricular Dysplasia, Familial, 1Tgfb3
Arsenic PoisoningTp53
ArteriosclerosisMapk9 , Tgfb1 , Tgfbr2
Arthritis, ExperimentalAkt1 , Bax , Bcl2 , Gsk3b , Pik3cd , Tgfbr2
Arthritis, JuvenileFos , Jun , Kras , Mapk1 , Smad3 , Tcf7l2
AsphyxiaJun
AsthmaBcl2 , Rhoa , Tgfb1
Asthma, OccupationalTgfb1
AstrocytomaAkt1 , Braf , Kras , Tp53
Ataxia-Oculomotor Apraxia 3Pik3r5
Ataxia-Telangiectasia-Like Disorder 1Msh6
AtherosclerosisAkt1
AtrophyMapk3
Autism Spectrum DisorderMapk3
Autistic DisorderApc , Bcl2
Autoimmune DiseasesTgfb2
Autoimmune Lymphoproliferative Syndrome, Type IVKras
AzoospermiaBcl2
B-Cell CLL/Lymphoma 2Bcl2
Bacterial InfectionsCasp3 , Casp9
Balkan NephropathyTp53
Bardet-Biedl SyndromeAkt3
Behcet SyndromeTgfb1
BerylliosisTgfb1
Bipolar DisorderAkt1 , Gsk3b
Bone DiseasesTgfbr2
Bone Diseases, DevelopmentalTgfb2 , Tp53
Bone Marrow NeoplasmsTp53
Bone NeoplasmsTgfbr2
BrachydactylySmad4
Brain InjuriesAkt1 , Bad , Bax , Bcl2 , Birc5 , Casp3 , Fos , Gsk3b , Jun , Rhoa
Brain IschemiaAkt1 , Bad , Bcl2 , Casp3 , Casp9 , Cycs , Jun , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Tgfb1 , Tp53
Brain NeoplasmsCcnd1 , Ctnnb1 , Pms2 , Tp53
Breast AdenocarcinomaAkt1 , Kras , Pik3ca , Tp53
Breast Cancer, FamilialPik3r3
Breast NeoplasmsAkt1 , Akt2 , Apc , Apc2 , Bad , Bax , Bcl2 , Birc5 , Braf , Casp3 , Casp9 , Ccnd1 , Ctnnb1 , Fos , Jun , Kras , Map2k1 , Mapk1 , Mlh1 , Msh2 , Myc , Pik3ca , Pik3r1 , Pms2 , Raf1 , Rhoa , Smad2 , Smad4 , Tgfb1 , Tp53
Burkitt LymphomaMyc , Pik3r1 , Tcf3
BurnsBad , Bax , Bcl2 , Casp3 , Ccnd1 , Gsk3b
CachexiaTgfb1
Cafe-au-Lait SpotsPms2
CalcinosisCasp3 , Ctnnb1 , Tgfb1
Camurati-Engelmann SyndromeTgfb1
CarcinogenesisBraf , Gsk3b , Kras
CarcinomaBcl2 , Ccnd1 , Kras , Myc , Pik3r1 , Rhoa , Tgfb1 , Tgfbr2 , Tp53
Carcinoma in SituAkt1 , Ctnnb1
Carcinoma, Acinar CellApc
Carcinoma, Adenoid CysticCcnd1 , Pik3ca , Tp53
Carcinoma, Basal CellPik3ca , Tp53
Carcinoma, Ductal, BreastSmad4
Carcinoma, EndometrioidBirc5 , Ctnnb1 , Kras
Carcinoma, HepatocellularAkt1 , Akt2 , Apc , Axin1 , Birc5 , Braf , Ccnd1 , Ctnnb1 , Fos , Jun , Kras , Myc , Pik3ca , Rac1 , Smad2 , Smad4 , Tgfb1 , Tgfbr2 , Tp53
Carcinoma, Intraductal, NoninfiltratingBcl2 , Birc5 , Ccnd1 , Tp53
Carcinoma, LobularCcnd1 , Ctnnb1
Carcinoma, Merkel CellMyc
Carcinoma, Non-Small-Cell LungAkt1 , Akt2 , Apc , Birc5 , Braf , Kras , Map2k1 , Myc , Pik3ca , Raf1 , Tp53
Carcinoma, Pancreatic DuctalKras , Pms1 , Tgfb1 , Tgfbr2
Carcinoma, Renal CellAkt1 , Apc , Bad , Bcl2 , Birc5 , Casp3 , Ccnd1 , Ctnnb1 , Jun , Kras , Map2k1 , Mlh1 , Msh2 , Myc , Pik3ca , Smad2 , Smad4 , Tp53
Carcinoma, Small CellBirc5 , Tp53
Carcinoma, Squamous CellAkt1 , Bcl2 , Birc5 , Ccnd1 , Kras , Mapk1 , Mapk3 , Myc , Pik3ca , Tgfb1 , Tp53
Carcinoma, Squamous Cell of Head and NeckAkt1 , Braf , Ctnnb1 , Map2k1 , Mapk1 , Pik3ca , Rac1 , Rhoa , Smad4 , Tp53
Carcinoma, Transitional CellApc , Bcl2 , Birc5 , Casp3 , Ccnd1 , Ctnnb1 , Kras , Smad4 , Tp53
CarcinosarcomaTgfb1
Cardiac FibrosisTgfb1
Cardiofaciocutaneous SyndromeBraf , Kras , Map2k1
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
CardiomegalyAkt1 , Bad , Gsk3b , Mapk1 , Mapk8 , Myc , Rac1 , Rhoa , Tgfb1
CardiomyopathiesAkt1 , Kras , Mapk1 , Mapk3 , Tp53
Cardiomyopathy, DilatedBax , Kras , Rac1 , Raf1
CARDIOMYOPATHY, DILATED, 1NNRaf1
Cardiomyopathy, HypertrophicBcl2 , Casp3 , Ctnnb1 , Kras , Myc , Raf1 , Tgfb1 , Tp53
Cardiomyopathy, Hypertrophic, FamilialKras , Raf1
Cardiovascular AbnormalitiesMap2k1
Carotid Artery DiseasesTgfb1 , Tp53
Carotid Artery InjuriesMyc
CataractMap2k1 , Tp53
Caudal Duplication AnomalyAxin1
Cecal NeoplasmsCcnd1 , Ctnnb1 , Kras , Tp53
Cell Transformation, NeoplasticApc , Bcl2 , Ccnd1 , Fos , Jun , Kras , Mapk8 , Myc , Rac1 , Tgfb1 , Tp53
Central Nervous System NeoplasmsTp53
Cerebral HemorrhageBax , Bcl2 , Casp3
Ceroid Lipofuscinosis, Neuronal, 6Gsk3b , Mapk1 , Mapk3
Cervical Intraepithelial NeoplasiaBcl2 , Ccnd1 , Mlh1 , Msh2
Chemotherapy-Induced Febrile NeutropeniaTp53
ChloracneCycs
CholangiocarcinomaApc , Cycs , Kras , Smad4 , Tgfb1 , Tgfbr2 , Tp53
CholangitisTgfb2
Cholesteatoma, Middle EarTp53
Chondrosarcoma, MesenchymalBcl2
ChorioamnionitisTgfb1
Choroid Plexus CarcinomaTp53
Chromosome 17 DeletionTp53
Chromosome BreakageMyc
Chronic Lymphoid LeukemiaBraf , Kras , Myc , Tp53
Chronic PeriodontitisRac2
CicatrixSmad4
Clear-Cell Metastatic Renal Cell CarcinomaMyc
Cleft LipMyc
Cleft PalateMyc , Tgfb1 , Tgfb2 , Tgfb3
Cocaine-Related DisordersFos , Mapk1 , Mapk3
Cognition DisordersSmad4
ColitisMsh2
Colitis, ExperimentalSmad4
Colitis, UlcerativeTp53
Colonic NeoplasmsAkt1 , Akt2 , Apc , Axin2 , Bad , Bax , Bcl2 , Birc5 , Braf , Ccnd1 , Ctnnb1 , Dcc , Jun , Kras , Lef1 , Mlh1 , Myc , Pik3ca , Pik3r1 , Pms2 , Tcf7l2 , Tgfbr2 , Tp53
Colorectal Cancer, Hereditary Nonpolyposis, Type 1Mlh1 , Msh2 , Msh6 , Pms1 , Pms2
Colorectal Cancer, Hereditary Nonpolyposis, Type 4Pms2
Colorectal Cancer, Hereditary Nonpolyposis, Type 5Msh6
Colorectal Cancer, Hereditary Nonpolyposis, Type 6Tgfbr2
Colorectal NeoplasmsAkt1 , Akt2 , Apc , Apc2 , Axin1 , Axin2 , Bax , Bcl2 , Birc5 , Braf , Ccnd1 , Ctnnb1 , Dcc , Kras , Map2k1 , Mlh1 , Msh2 , Msh3 , Msh6 , Pik3ca , Pik3r1 , Pms1 , Pms2 , Raf1 , Rhoa , Smad4 , Smad7 , Tcf7l2 , Tgfb1 , Tgfbr1 , Tp53
Colorectal Neoplasms, Hereditary NonpolyposisApc , Mlh1 , Msh2 , Msh6 , Pms1 , Pms2 , Smad2 , Smad3 , Smad4 , Tgfbr1 , Tgfbr2
Congenital AbnormalitiesRac2
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Conjunctivitis, AllergicTgfb1
Copper-Overload CirrhosisCasp3 , Smad2 , Tgfb1
Coronary Artery DiseaseAkt1 , Tgfb1
Coronary RestenosisMapk1 , Myc , Tp53
Costello SyndromeBraf , Kras , Map2k1
COWDEN SYNDROME 5Pik3ca
Cranioectodermal DysplasiaTgfb3
Craniofacial AbnormalitiesCtnnb1 , Smad2 , Smad3 , Smad4 , Tgfb2 , Tgfbr2 , Tp53
CraniopharyngiomaBraf , Ctnnb1
Crohn DiseaseSmad3 , Tcf7
CryptorchidismCasp3
Currarino TriadPik3ca
CyanosisTgfb2
Cystadenocarcinoma, SerousTp53
Cystic FibrosisTgfb1
DeafnessSmad4
Deafness, Autosomal Recessive 9Msh6
DementiaBax , Bcl2
Dementia, Multi-InfarctBax , Bcl2
Dementia, VascularTp53
Demyelinating DiseasesMyc , Tp53
Depressive DisorderBax , Gsk3b , Jun
Dermatitis, Allergic ContactBcl2
Dermatitis, AtopicMapk8 , Tgfb1
Dermatitis, ContactBcl2
DermatomyositisPms1
Desmoid Disease, HereditaryApc , Ctnnb1
Developmental DisabilitiesAkt3
Diabetes MellitusRac1 , Tcf7l2
Diabetes Mellitus, ExperimentalAkt1 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Mapk1 , Mapk3 , Myc , Pik3r1 , Rhoa , Tgfb1 , Tgfb2 , Tp53
Diabetes Mellitus, Type 1Casp3 , Casp9 , Tgfb1
Diabetes Mellitus, Type 2Akt1 , Akt2 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Gsk3b , Pik3r1 , Smad4 , Tcf7l2 , Tgfb1 , Tgfbr2
Diabetes, GestationalTcf7l2
Diabetic AngiopathiesCasp3
Diabetic CardiomyopathiesBad , Bcl2
Diabetic CystopathyBad
Diabetic NephropathiesCasp3 , Mapk1 , Tcf7l2 , Tgfb1 , Tgfbr2 , Tp53
Diabetic NeuropathiesBad , Casp3 , Tgfb1 , Tgfb2 , Tgfb3
Diabetic RetinopathyCasp3 , Casp9
Diaphyseal Dysplasia 1, ProgressiveTgfb1
Digestive System NeoplasmsApc , Msh3
Dilatation, PathologicTgfb1
DiseaseCtnnb1
Disease Models, AnimalAkt1 , Fos , Kras , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Rhoa , Tp53
Disease ProgressionBcl2 , Myc
Drug-Induced Liver InjuryBad , Bax , Ctnnb1
Drug-induced NeutropeniaTp53
Drug-Related Side Effects and Adverse ReactionsTp53
Dry Eye SyndromesTgfb1
Duodenal UlcerTgfb1
Dysembryoplastic Neuroepithelial TumorBraf
Dyskeratosis Congenita, Autosomal RecessiveTp53
EdemaCasp3 , Casp9
Ehlers-Danlos SyndromeTgfb1
EmphysemaTp53
Encephalomyelitis, Autoimmune, ExperimentalCasp3 , Casp9 , Rhoa , Tgfb1 , Tgfb2
Endodermal Sinus TumorCtnnb1
Endometrial HyperplasiaBirc5 , Kras
Endometrial NeoplasmsBcl2 , Birc5 , Ccnd1 , Ctnnb1 , Jun , Kras , Mlh1 , Msh2 , Msh3 , Msh6 , Myc , Pik3ca , Smad2 , Smad3 , Smad4 , Smad7 , Tp53
EndometriosisBax , Bcl2 , Birc5 , Fos , Kras , Tgfb2
Endomyocardial FibrosisTgfb1
EndotoxemiaBax , Bcl2 , Casp3
Eosinophilic EsophagitisTgfb1
Epidermal NevusKras , Pik3ca
EpilepsyAkt1 , Fos
Epilepsy, GeneralizedMapk10
Epileptic Encephalopathy, Lennox-Gastaut TypeMapk10
Erectile DysfunctionAkt1 , Bad , Bax , Bcl2 , Casp3 , Ccnd1 , Tgfb1
Esophageal NeoplasmsBax , Bcl2 , Ccnd1 , Dcc , Myc , Tgfbr2 , Tp53
Esophageal Squamous Cell CarcinomaCcnd1 , Ctnnb1 , Tp53
Exudative vitreoretinopathy 1Ctnnb1
Eye AbnormalitiesApc , Tgfb2 , Tgfbr2
Facial AsymmetryPik3ca
FAMILIAL ADENOMATOUS POLYPOSIS 4Msh3
Familial Primary Pulmonary HypertensionSmad4
FatigueTgfbr2
Fatty LiverCycs , Mapk8 , Myc
Femoral FracturesLef1
Fetal Alcohol SyndromeRhoa
Fetal Growth RetardationBax , Bcl2 , Casp3
Fibromatosis, AbdominalApc
Fibromatosis, AggressiveApc
FibrosisAkt1 , Rhoa , Tgfb1
Fibrous Dysplasia of BoneFos
Fractures, BoneTgfbr2
Gallbladder NeoplasmsApc , Bcl2 , Kras , Tgfb1 , Tp53
Gardner SyndromeApc
Gastrointestinal HemorrhageBax
Gastrointestinal NeoplasmsApc , Pik3ca , Smad4
Gastrointestinal Stromal TumorsBraf , Kras
Gaze Palsy, Familial Horizontal, with Progressive ScoliosisDcc
Genetic Diseases, InbornCtnnb1 , Mapk1 , Pik3r2 , Smad2
Genital Diseases, FemaleSmad2
Genomic InstabilityCcnd1
GerminomaBraf
GlaucomaBad , Bax , Bcl2 , Tgfb2
Glaucoma, Primary Open AngleTp53
GlioblastomaAkt1 , Apc , Braf , Myc , Pik3ca , Pik3r1 , Tp53
GliomaAkt2 , Bad , Birc5 , Braf , Pik3ca , Raf1 , Tp53
GliosisMapk1 , Mapk3
GlomerulonephritisBax , Bcl2 , Fos , Mapk1
Glomerulonephritis, IGATgfb1
Glomerulonephritis, MembranoproliferativeTgfbr2
Glomerulonephritis, MembranousRhoa
Glomerulosclerosis, Focal SegmentalTgfb1
Graft vs Host DiseaseTp53
Granulosa Cell TumorCtnnb1
Graves DiseaseTp53
Growth DisordersPik3ca
Growth Mental Deficiency Syndrome of MyhreSmad4
Hamartoma Syndrome, MultipleAkt1 , Pik3ca
Head and Neck NeoplasmsBcl2 , Mapk1 , Mapk3 , Pik3ca , Tp53
Hearing Loss, Cisplatin-InducedGsk3b
Heart ArrestAkt1
Heart Defects, CongenitalTgfb2
Heart DiseasesBax , Casp9 , Rac2 , Tgfb1
Heart FailureBax , Bcl2 , Birc5 , Fos , Gsk3b , Rac1 , Tp53
Heart Septal Defects, VentricularBraf , Fos , Tgfb3
Heart Valve DiseasesCasp3
Heat StrokeFos , Jun
Hemangioma, CapillaryAkt3
HemangiosarcomaCcnd1 , Ctnnb1 , Jun , Kras , Myc , Tp53
HematuriaFos
HemimegalencephalyPik3ca
Hemolytic-Uremic SyndromeFos
Hemophilia ATgfb1
HemorrhageFos
Hepatitis, AutoimmuneTgfb1
Hepatitis, ChronicCasp3 , Smad2 , Tgfb1
HepatoblastomaApc , Ctnnb1 , Tp53
Hepatoblastoma Caused By Somatic MutationApc , Ctnnb1
Hepatolenticular DegenerationMsh2
Hernia, DiaphragmaticTgfb1
Hernia, InguinalTgfbr2
Hernias, Diaphragmatic, CongenitalRhoa
HIV InfectionsBax
Hodgkin DiseaseJun
Holt-Oram SyndromeTgfb2
Huntington DiseaseBax , Bcl2 , Msh2
Hydatidiform MoleMlh1 , Msh2
Hydatidiform Mole, InvasiveMsh2
HyperalgesiaFos , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Raf1
HyperbilirubinemiaBcl2
HyperkinesisFos
HyperlipidemiasApc , Tgfb1
HyperoxiaTgfb1
HyperparathyroidismCcnd1 , Myc
HyperplasiaAkt1 , Apc , Bax , Ccnd1 , Pik3ca , Tcf7l2 , Tgfb1 , Tgfbr2
HypersensitivityTgfb1
HypertensionAkt1 , Akt2 , Bad , Bax , Bcl2 , Casp3 , Fos , Gsk3b , Jun , Kras , Mapk8 , Pik3r1 , Rhoa , Tgfb1 , Tgfb3 , Tp53
Hypertension, PortalPik3r1
Hypertension, PulmonaryBcl2 , Birc5 , Myc , Rhoa , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53
HypertrophyMapk1 , Mapk3
Hypertrophy, Left VentricularMyc , Rac1 , Rhoa
Hypertrophy, Right VentricularAkt1 , Tgfb1
Hypoglossal Nerve InjuriesSmad2 , Smad3 , Smad4 , Smad7
HypoglycemiaAkt2 , Pik3r1
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
HypothermiaBcl2
HypothyroidismBad
Hypoxia-Ischemia, BrainBax , Bcl2 , Casp3
Immunoblastic LymphadenopathyRhoa
Immunodeficiency 14Pik3cd
Immunodeficiency 36Pik3r1
Impotence, VasculogenicTgfbr2
Infarction, Middle Cerebral ArteryBad , Bax , Bcl2 , Casp3 , Fos
InfectionCtnnb1
Infections, Recurrent, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsMsh2
Infertility, FemaleMapk1 , Mapk3 , Tp53
Infertility, MaleBax , Bcl2 , Tp53
InflammationAkt1 , Tgfb1
Inflammatory Bowel Disease 11Casp3
Inflammatory Bowel DiseasesApc , Apc2
Insulin ResistanceAkt2 , Bad , Pik3r1 , Tcf7l2
InsulinomaTgfb1
Intellectual DisabilityApc , Dcc , Kras , Ralgds
Intermittent ClaudicationBad , Bax , Casp3
Intervertebral Disc DegenerationTgfb1
Intervertebral Disc DisplacementAkt1
Intestinal DiseasesBax , Bcl2 , Casp3
Intestinal NeoplasmsApc , Bax , Bcl2 , Ctnnb1
Intestinal PolyposisSmad4
Intestinal PolypsApc , Ccnd1 , Jun
Intracranial AneurysmBcl2
IschemiaAkt2 , Bax , Cycs , Mapk9 , Raf1 , Tp53
Ischemic Attack, TransientBad , Bax , Bcl2 , Casp3 , Casp9 , Cycs
Joubert Syndrome 3Msh6
Juvenile Polyposis SyndromeSmad4
Juvenile Polyposis with Hereditary Hemorrhagic TelangiectasiaSmad4
Kashin-Beck DiseaseBax , Bcl2
Keratoacanthoma FamilialTgfbr1
KeratosisTp53
Keratosis, ActinicTgfb1
Keratosis, SeborrheicPik3ca
Kidney DiseasesMapk1 , Tgfb1 , Tgfbr1 , Tgfbr2
Kidney Failure, ChronicBcl2 , Tgfb1
Kidney NeoplasmsAkt1 , Birc5 , Braf , Ccnd1 , Jun , Kras , Mapk1 , Mapk3 , Raf1
Kidney Reperfusion InjuryBax , Bcl2 , Casp3 , Fos , Myc
Laryngotracheal Stenosis, Progressive, with Short Stature and ArthropathySmad4
Learning DisordersBcl2
LeiomyomaBax , Bcl2 , Myc , Smad3 , Tgfbr1
LEOPARD SyndromeBraf , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD syndrome, 2Raf1
LeukemiaBad , Ccnd1 , Tp53
Leukemia, B-CellMyc
Leukemia, Hairy CellMap2k1
Leukemia, Lymphocytic, Chronic, B-CellBcl2 , Braf , Kras , Lef1 , Tp53
Leukemia, Megakaryoblastic, AcuteBirc5 , Tp53
Leukemia, Megakaryoblastic, of Down SyndromeTp53
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveBirc5 , Braf
Leukemia, Myeloid, AcuteBcl2 , Ccnd1 , Kras , Myc , Tp53
Leukemia, Myelomonocytic, JuvenileKras , Rac2
Leukemia, Promyelocytic, AcuteAkt1 , Myc
Leukemia-Lymphoma, Adult T-CellBirc5 , Tp53
LeukocytosisApc , Kras
Leukodystrophy, Hypomyelinating, 8, with or without Oligodontia and/or Hypogonadotropic HypogonadismMsh6
Leukoplakia, OralBcl2 , Tp53
Li-Fraumeni SyndromeTp53
Li-Fraumeni Syndrome 2Tp53
Li-Fraumeni-Like SyndromeTp53
Lichen Planus, OralTp53
Limb Deformities, CongenitalTgfb2
Lip NeoplasmsTp53
Lipodystrophy, Familial PartialAkt2
Liver CirrhosisCtnnb1 , Smad3 , Tgfb1
Liver Cirrhosis, AlcoholicBcl2 , Smad3 , Tgfb1
Liver Cirrhosis, ExperimentalAppl1 , Bcl2 , Birc5 , Fos , Myc , Rac2 , Rhoa , Smad2 , Smad4 , Tgfb1 , Tgfb3 , Tgfbr1 , Tgfbr2
Liver DiseasesRac1
Liver Diseases, ParasiticKras , Smad4 , Tp53
Liver Failure, AcuteMapk8
Liver InjuryMyc
Liver NeoplasmsAkt1 , Apc , Axin1 , Braf , Ccnd1 , Ctnnb1 , Jun , Kras , Myc , Pik3ca , Raf1 , Tp53
Liver Neoplasms, ExperimentalBcl2 , Birc5 , Ccnd1 , Ctnnb1 , Kras , Map2k1 , Myc , Tp53
Liver Reperfusion InjuryBad , Bax , Bcl2 , Mapk8
Loeys-Dietz SyndromeSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
LOEYS-DIETZ SYNDROME 2Tgfbr2
Loeys-Dietz Syndrome 3Smad3
Loeys-Dietz Syndrome 4Tgfb2 , Tgfb3
Loeys-Dietz Syndrome 5Tgfb3
Loeys-Dietz Syndrome, Type 1bTgfbr2
Low Tension GlaucomaTp53
Lung DiseasesTgfb1
Lung Diseases, InterstitialTgfb1
Lung NeoplasmsAkt1 , Apc , Birc5 , Braf , Ccnd1 , Ctnnb1 , Fos , Jun , Kras , Mapk1 , Mapk3 , Mlh1 , Myc , Pik3ca , Raf1 , Tgfb1 , Tgfbr2 , Tp53
Lung Reperfusion InjuryBax , Bcl2 , Casp3 , Myc
Lupus Erythematosus, SystemicTcf7
Lymphatic MetastasisBcl2 , Birc5 , Ctnnb1 , Rhoa , Smad4 , Tp53
LymphomaKras , Mlh1 , Rac2 , Tp53
Lymphoma, B-Cell, Marginal ZoneTp53
Lymphoma, FollicularBcl2
Lymphoma, Large B-Cell, DiffuseBcl2 , Pik3ca , Pik3cb , Pik3cd
Lymphoma, Mantle-CellCcnd1 , Ctnnb1 , Gsk3b , Pik3cd
Lymphoma, Non-HodgkinBcl2 , Braf , Ccnd1 , Map2k1 , Myc , Pik3ca , Rhoa , Tp53
Lymphoma, T-CellAkt1 , Rhoa , Tp53
Lymphoma, T-Cell, CutaneousBax , Braf , Rhoa , Tp53
Lymphoma, T-Cell, PeripheralRhoa
Lynch Syndrome IIMlh1
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
Macular DegenerationBad , Bax
Malformations of Cortical DevelopmentAkt3 , Pik3ca
Mammary Neoplasms, AnimalApc , Ccnd1 , Pik3r1
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Ccnd1 , Ctnnb1 , Myc , Pik3r1 , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53
Mandibular NeoplasmsBraf
Marfan SyndromeTgfbr2
Marijuana AbuseAkt1
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 14Appl1
MedulloblastomaApc , Ctnnb1 , Myc , Pik3ca , Tp53
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
MelanomaAkt1 , Bcl2 , Braf , Ctnnb1 , Dcc , Kras , Map2k1 , Myc , Pik3ca , Pik3r1 , Rac1 , Rac2 , Raf1 , Tp53
Melanoma, Cutaneous Malignant, Susceptibility To, 1Akt1 , Braf , Ctnnb1 , Map2k1 , Pik3ca , Rac1 , Raf1 , Tp53
Memory DisordersBcl2
Meningeal NeoplasmsAkt1
MeningiomaAkt1
Mental Retardation, Autosomal Dominant 19Ctnnb1
Mercury Poisoning, Nervous SystemJun
MesotheliomaApc , Tp53
Mesothelioma, MalignantBcl2 , Ctnnb1 , Raf1 , Tgfb2 , Tp53
Metabolic Syndrome XTgfb1
MetaplasiaAxin2 , Bcl2
Methylmalonic AcidemiaCycs
Microphthalmia, Cataracts, and Iris AbnormalitiesSmad4
Microsatellite InstabilityBax , Braf , Msh3 , Msh6 , Tgfbr2
Migraine DisordersTgfbr2
Mirror Movements 1Dcc
Miyoshi MyopathyApc
Monoclonal B-Cell LymphocytosisApc
Mood DisordersAkt1
Morphine DependenceBax , Bcl2
Mouth NeoplasmsKras , Pik3ca , Tp53
Muir-Torre SyndromeMlh1 , Msh2
Multiple MyelomaBcl2 , Braf , Ccnd1 , Kras , Pik3ca , Tgfb1 , Tp53
Multiple Organ FailureMapk1
Multiple SclerosisRhoa
Muscular AtrophyAkt1 , Ctnnb1 , Gsk3b
Muscular DiseasesSmad4 , Tgfb1
Muscular Dystrophy, DuchenneTgfb1
Muscular Dystrophy, Limb-Girdle, Type 2BApc
Musculoskeletal AbnormalitiesTgfb2
Mycoplasma InfectionsCasp3
Myelodysplastic SyndromesKras , Myc , Tp53
Myeloproliferative DisordersKras
Myocardial InfarctionAkt1 , Bax , Bcl2 , Birc5 , Casp3 , Gsk3b , Mapk1 , Smad2 , Smad4 , Tgfb1 , Tgfb2 , Tgfbr1 , Tgfbr2 , Tp53
Myocardial IschemiaBax , Bcl2 , Ccnd1
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Gsk3b , Mapk1 , Mapk8 , Mapk9 , Rhoa , Smad3 , Smad4 , Tgfb1 , Tp53
Myoclonus, Familial CorticalMyc
Myopathy, Distal, with Anterior Tibial OnsetApc
Nasal PolypsJun , Tgfb1
Nasopharyngeal carcinomaAkt2 , Bcl2 , Ccnd1 , Kras , Pik3ca , Tp53
Nasopharyngeal NeoplasmsCcnd1 , Pik3ca , Tp53
NecrosisBcl2
Nematode InfectionsPik3r1
Neoplasm InvasivenessCtnnb1 , Mapk1 , Mapk3 , Rhoa , Tgfb1
Neoplasm MetastasisAkt2 , Bax , Bcl2 , Braf , Casp3 , Ctnnb1 , Kras , Mapk1 , Mapk3 , Mapk9 , Mlh1 , Msh2 , Myc , Pms2 , Rac1 , Rhoa , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53
NeoplasmsApc , Braf , Ctnnb1 , Kras , Map2k1 , Myc , Pik3ca , Pik3r1 , Tp53
Neoplasms, ExperimentalCcnd1 , Kras , Tp53
Neoplasms, Germ Cell and EmbryonalBirc5 , Mlh1 , Msh2 , Rhoa
Neoplasms, Multiple PrimaryMlh1
Neoplastic Syndromes, HereditaryApc , Axin2 , Mlh1 , Msh2 , Msh6 , Pik3ca , Pms2 , Smad4 , Tp53
NephritisSmad7
Nephritis, InterstitialBax
Nephrolithiasis, Calcium OxalateTgfb1
Nephrotic SyndromeTgfb1
Nerve DegenerationBax , Bcl2 , Casp3 , Ctnnb1 , Mapk1 , Mapk3
Nerve Sheath NeoplasmsTp53
Nervous System DiseasesCasp3 , Casp9 , Fos , Tp53
NeuralgiaTgfb1
Neuritis, Autoimmune, ExperimentalDcc , Rhoa
NeuroblastomaKras , Myc , Pik3ca , Tp53
Neurodevelopmental DisordersCtnnb1 , Tcf7l2
Neuroectodermal TumorsMyc
Neuroectodermal Tumors, PrimitivePms2
Neuroendocrine TumorsBraf
Neurotoxicity SyndromesCasp3 , Fos
Neutrophil Immunodeficiency SyndromeRac2
NevusBraf
Nevus, Sebaceous of JadassohnKras
Niemann-Pick Disease, Type BApc
No-Reflow PhenomenonCtnnb1
Non-alcoholic Fatty Liver DiseaseTgfb1
Nonseminomatous Germ Cell TumorBraf
Noonan SyndromeBraf , Kras , Map2k1 , Raf1
Noonan syndrome 3Kras
Noonan Syndrome 5Raf1
Noonan Syndrome 7Braf
Nose NeoplasmsTp53
ObesityAkt1 , Akt2 , Bad , Bcl2 , Cycs , Myc , Pik3r1 , Rhoa , Tgfb1
Occupational DiseasesTgfb1
Odontogenic CystsSmad4
Odontogenic MyxomaTp53
Oligodontia-Colorectal Cancer SyndromeAxin2
Optic Atrophy, Hereditary, LeberTp53
Optic Nerve InjuriesBax , Bcl2 , Jun , Rhoa
Oral Submucous FibrosisTgfb1 , Tp53
Oropharyngeal NeoplasmsTp53
Osseous Heteroplasia, ProgressiveCtnnb1
Ossification, HeterotopicSmad4
OsteoarthritisBad , Bax , Bcl2 , Smad3
Osteoarthritis, KneeBax , Bcl2 , Ctnnb1
OsteochondrodysplasiasBcl2 , Tgfb1 , Tgfb2 , Tgfbr1
OsteopetrosisJun
OsteoporosisBax , Bcl2 , Myc , Tgfb1
Osteoporosis, PostmenopausalTgfb1
OsteosarcomaAkt1 , Jun , Myc , Tp53
Ovarian Epithelial CancerPik3ca , Tp53
Ovarian NeoplasmsAkt1 , Akt2 , Bcl2 , Birc5 , Braf , Ccnd1 , Ctnnb1 , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Mlh1 , Msh2 , Msh6 , Myc , Pik3ca , Pik3r1 , Pms2 , Rhoa , Smad2 , Smad4 , Smad7 , Tp53
Oxygen-Induced RetinopathyMapk8
PainAkt1
Pancreatic AdenocarcinomaCtnnb1 , Kras , Pik3ca , Smad4 , Tp53
Pancreatic CarcinomaKras , Smad4 , Tp53
Pancreatic NeoplasmsAkt2 , Apc , Ctnnb1 , Cycs , Kras , Myc , Smad3 , Smad4 , Tcf7l2 , Tgfb1 , Tgfbr2 , Tp53
PancreatitisCasp3
Pancreatitis, AcuteBirc5
Pancreatitis, Acute NecrotizingBirc5 , Casp3
Pancreatitis, ChronicBad
Pancreatitis, Experimental, Acute Kras
Papillary Renal Cell Carcinoma, SporadicBraf , Myc , Pik3ca , Tp53
PapillomaCcnd1 , Tgfb1
Papilloma, Choroid PlexusTp53
Paranasal Sinus NeoplasmsTp53
ParaplegiaAkt1
Paraquat LungSmad7 , Tgfb1
Parkinson DiseaseAkt1 , Gsk3b
Parkinsonian DisordersBad
Penile IndurationTgfb1
Penile NeoplasmsCcnd1 , Kras , Pik3ca , Tp53
Periampullary AdenomaApc
Peripheral Nervous System DiseasesCasp9 , Jun
Peritoneal FibrosisTgfb1
Peritoneal NeoplasmsCtnnb1
PeritonitisGsk3b
Phyllodes TumorCtnnb1 , Tp53
Pick Disease of the BrainFos
PilomatrixomaCtnnb1
PlasmacytomaBcl2
Pleomorphic Xanthoastrocytoma Braf , Cycs
Pleural DiseasesTgfb1
PneumoniaTgfb1
Pneumonia, PneumococcalMapk1 , Mapk3
PoisoningGsk3b
Polycystic Kidney Disease, Type 1Myc
Polycystic Kidney DiseasesMyc
Polycystic Kidney, Autosomal DominantFos , Myc
Polycystic Kidney, Autosomal RecessiveAkt1 , Myc , Pik3ca
Polycystic Ovary SyndromeBax , Bcl2
PolymicrogyriaAkt3
PolymyositisPms1
PolyploidyTp53
Precancerous ConditionsAkt1 , Ccnd1 , Mapk8 , Mapk9 , Smad3 , Smad4 , Tp53
Precursor B-Cell Lymphoblastic Leukemia-LymphomaCcnd1 , Tcf3 , Tp53
Precursor Cell Lymphoblastic Leukemia-LymphomaBcl2 , Ccnd1 , Kras , Myc , Tcf3 , Tp53
Precursor T-Cell Lymphoblastic Leukemia-LymphomaBax , Bcl2 , Kras
PriapismBcl2
Primary MyelofibrosisTgfb1 , Tp53
ProlactinomaMyc
Prostatic HyperplasiaBad , Myc
Prostatic Intraepithelial NeoplasiaCcnd1 , Kras , Myc , Smad4
Prostatic NeoplasmsAkt1 , Apc , Bad , Bax , Bcl2 , Birc5 , Braf , Casp3 , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Jun , Kras , Map2k1 , Mapk10 , Mapk3 , Mlh1 , Msh2 , Msh3 , Myc , Pik3ca , Pik3cd , Pik3r1 , Pms2 , Rac2 , Smad3 , Smad4 , Tgfb1 , Tgfbr2 , Tp53
ProstatitisSmad4
ProteinuriaRhoa , Tgfb1
Proteus SyndromeAkt1
PsoriasisTgfb1 , Tp53
Psychoses, Substance-InducedAkt1
PterygiumTp53
Pulmonary Disease, Chronic ObstructiveMapk8 , Smad4 , Tgfb1 , Tp53
Pulmonary EmphysemaTgfb1
Pulmonary FibrosisBad , Smad4 , Smad7 , Tgfb1 , Tgfbr2
Purpura, Thrombocytopenic, IdiopathicTgfb1
Radiation InjuriesTgfbr2
Radiation Injuries, ExperimentalMapk1 , Mapk3
Radiation PneumonitisTgfb1
RASopathiesBraf , Kras , Map2k1 , Raf1
Rectal NeoplasmsApc , Pik3ca
RecurrenceKras
Renal FibrosisKras , Mapk1 , Myc
Reperfusion InjuryAkt1 , Bad , Bax , Bcl2 , Birc5 , Casp3 , Casp9 , Ccnd1 , Dcc , Fos , Jun , Mapk8 , Mapk9 , Pik3r1 , Tgfbr2 , Tp53
Respiratory Distress Syndrome, AdultApc
Respiratory System AbnormalitiesTgfb2 , Tgfb3
Retina Reperfusion InjuryBad , Bax , Bcl2
Retinal DegenerationBax , Bcl2
Retinal DetachmentCasp3 , Casp9
Retinal DiseasesCasp3
Rhabdoid TumorMyc
RhabdomyosarcomaPms2 , Tp53
RhinitisTgfb1
Rhinitis, AllergicBcl2
Salivary Gland DiseasesCasp3
Salivary Gland NeoplasmsCcnd1
SarcoidosisTgfb1
Sarcoidosis, PulmonaryTgfb1
SarcomaPik3ca , Tp53
Sarcoma Family Syndrome of Li and FraumeniTp53
Sarcoma, ExperimentalKras
Sarcoma, KaposiTp53
Sarcoma, MyeloidKras
Sarcoma, SynovialBcl2
SarcopeniaBax , Bcl2
SchizophreniaAkt1 , Gsk3b , Mapk3 , Pik3cb , Tp53
Scleroderma, LocalizedTgfb1
Sebaceous Gland NeoplasmsLef1
Sebaceous Nevus Syndrome and HemimegalencephalyKras
SeizuresBad , Ccnd1 , Fos , Msh2
SeminomaKras , Smad4
Senior Loken SyndromeAkt3
SepsisBad , Casp3 , Gsk3b , Mapk1 , Mapk3 , Tgfb1
Septic PeritonitisPik3r1
Sezary SyndromeBraf , Mapk1 , Tp53
Shock, HemorrhagicBad , Bcl2 , Mapk1 , Myc
SHORT SyndromePik3r1
Sjogren's SyndromeTgfb1
Skin NeoplasmsAkt1 , Ctnnb1 , Tgfb1 , Tgfbr1 , Tp53
Small Cell Lung CarcinomaAkt1 , Pik3ca , Tp53
Small-For-Size SyndromeBad
Smith-Magenis SyndromeAxin2 , Birc5
Soft Tissue NeoplasmsBcl2
SOTOS SYNDROME 3Apc2
Spinal Cord InjuriesAkt1 , Casp3 , Dcc , Jun , Tgfb1 , Tgfb2 , Tp53
Spinal Cord Reperfusion InjuryBad
Spinocerebellar Ataxia, Autosomal Recessive 8Apc
SplenomegalyApc , Kras
Spondylocostal Dysostosis 5Mapk3
Squamous Cell Carcinoma of the LungAkt1 , Braf , Kras , Pik3ca , Tp53
Squamous Cell Carcinoma of the TongueTp53
Status EpilepticusBax , Bcl2 , Casp3 , Ccnd1 , Fos , Gsk3b , Jun
Stevens-Johnson SyndromeCtnnb1
Stomach NeoplasmsApc , Birc5 , Ccnd1 , Ctnnb1 , Jun , Kras , Mapk1 , Mapk3 , Mapk8 , Myc , Pik3ca , Rhoa , Smad4 , Tp53
Stomach UlcerBad , Bcl2
Stress Disorders, Post-TraumaticBax , Bcl2
StrokeAkt1 , Casp3 , Ctnnb1 , Mapk8 , Tgfb1
Subarachnoid HemorrhageCasp3
Substance Withdrawal SyndromeFos , Mapk1 , Mapk3
Supratentorial NeoplasmsPms2
SyndromeRac2
Tachycardia, VentricularRaf1
TauopathiesGsk3b
Telangiectasia, Hereditary HemorrhagicSmad4
Telangiectasia, Hereditary Hemorrhagic, Type 1Tgfb1
Tendon InjuriesFos
TeratomaBax , Ctnnb1
Thrombocythemia, EssentialTgfb1
ThrombocytopeniaCycs , Tgfb1
Thrombocytopenia 4Cycs
ThrombosisPik3cb
ThymomaTp53
Thymus NeoplasmsTp53
Thyroid Cancer, FollicularBraf
Thyroid Cancer, MedullaryKras
Thyroid cancer, papillaryBraf
Thyroid Carcinoma, AnaplasticTp53
Thyroid NeoplasmsBraf , Ccnd1 , Kras , Tp53
ThyroiditisBax
Tongue NeoplasmsBcl2 , Fos , Tp53
ToxoplasmosisBax
Tracheal StenosisTgfb1
Transplant RejectionMyc
Trigeminal Nerve InjuriesTp53
Trigeminal NeuralgiaFos , Mapk1 , Mapk3 , Mapk8 , Mapk9
Tuberculosis, PulmonaryJun
Tumor Predisposition SyndromeApc , Mlh1 , Msh2 , Msh6 , Pms2 , Smad4 , Tp53
Turcot SyndromeApc , Mlh1 , Msh2 , Msh6 , Pms2
UremiaTgfb1 , Tgfbr1
Ureteral ObstructionAkt1 , Tgfb1 , Tgfb2
Urethral ObstructionMapk1 , Tgfb1
Urinary Bladder NeoplasmsAkt1 , Bax , Bcl2 , Birc5 , Casp3 , Casp9 , Ctnnb1 , Kras , Mlh1 , Msh2 , Myc , Pms2 , Rhoa , Smad2 , Smad4 , Tgfbr1 , Tp53
Urinary IncontinenceMapk1
Urogenital AbnormalitiesTgfb2
Urogenital NeoplasmsMsh2 , Tp53
Urologic NeoplasmsBirc5 , Ccnd1 , Rhoa , Tp53
UrticariaTgfb1
Uterine Cervical NeoplasmsAkt1 , Bax , Birc5 , Casp3 , Ccnd1 , Ctnnb1 , Fos , Kras , Mapk1 , Mlh1 , Msh2 , Myc , Pik3ca , Smad2 , Smad4 , Tp53
Uterine NeoplasmsCtnnb1 , Kras , Smad3
UveitisTgfb1
VaricoceleCasp9
Ventilator-Induced Lung InjuryAkt1
Ventricular Premature ComplexesTgfb3
Ventricular RemodelingSmad2 , Smad3 , Tgfb1
VitiligoTgfb1
von Hippel-Lindau DiseaseCcnd1
Vulvar Lichen SclerosusTp53
Vulvar NeoplasmsMlh1 , Msh2 , Tp53
Wallerian DegenerationTgfb1 , Tgfb2
Weight GainPik3ca
Wet Macular DegenerationMapk8
Wilms TumorCtnnb1 , Myc
Wounds and InjuriesTgfb1 , Tgfb2 , Tgfb3
Xeroderma PigmentosumTp53
Pathway Annotations Associated with Genes in the colorectal cancer pathway
Pathway TermsGene Symbols
activin signaling pathwaySmad2 , Smad3
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tcf3 , Tcf7 , Tcf7l2
adenosine signaling pathwayAkt1 , Bad , Braf , Jun , Mapk1 , Mapk8 , Pik3ca
aldosterone signaling pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered mismatch repair pathwayMlh1 , Msh2 , Msh6 , Pms1 , Pms2
altered p53 signaling pathwayTp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
altered transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
altered Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Ctnnb1 , Tcf7l2
Alzheimer disease pathwayBad , Casp3 , Casp9 , Cycs , Cyct , Gsk3b , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayBad , Bax , Bcl2 , Casp3 , Casp9 , Cycs , Cyct , Rac1 , Tp53
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Cycs , Cyct , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
Arf family mediated signaling pathwayRac1
arrhythmogenic right ventricular cardiomyopathy pathwayCtnnb1 , Lef1 , Tcf3 , Tcf7 , Tcf7l2
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Fos , Gsk3b , Jun , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1
basal cell carcinoma pathwayApc , Apc2 , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
bladder cancer pathwayBraf , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Myc , Raf1 , Tp53
Bone morphogenetic proteins signaling pathwayGsk3b , Mapk1 , Smad4 , Smad7
c-Jun N-terminal kinases MAPK signaling pathwayMapk10 , Mapk8 , Mapk9 , Rac1
calcium signaling pathway via the calcium-sensing receptorRhoa
cardiolipin metabolic pathwayCycs
cell cycle pathway, mitoticCcnd1 , Gsk3b , Myc , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tp53
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Bax , Bcl2 , Braf , Casp9 , Ccnd1 , Cycs , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Ralgds , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Gsk3b , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Rhoa , RSA-14-44
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Apc , Apc2 , Appl1 , Axin1 , Axin2 , Bad , Bax , Bcl2 , Birc5 , Braf , Casp3 , Casp9 , Ccnd1 , Ctnnb1 , Cycs , Cyct , Dcc , Fos , Gsk3b , Jun , Kras , Lef1 , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mlh1 , Msh2 , Msh3 , Msh6 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pms1 , Pms2 , Rac1 , Rac2 , Raf1 , Ralgds , Rhoa , RSA-14-44 , Smad2 , Smad3 , Smad4 , Smad7 , Tcf3 , Tcf7 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
cytokine mediated signaling pathwayTgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
dilated cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Ctnnb1 , Pik3ca , Pik3r1 , Rac1 , Rhoa
eicosanoid signaling pathwayAkt1 , Pik3r5 , Rac1 , Rhoa
electron transport chain pathwayCycs
endocytosis pathwayRhoa , RSA-14-44 , Smad2 , Smad3 , Smad7 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Apc , Apc2 , Axin1 , Axin2 , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Mlh1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Endoplasmic Reticulum-associated degradation pathwayBax , Bcl2 , Mapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Fos , Jun , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Rac1 , Raf1 , Rhoa
Entamoeba histolyca infection pathwayCasp3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tgfb1 , Tgfb2 , Tgfb3
ephrin - ephrin receptor bidirectional signaling axisMap2k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1 , Pik3r5 , Rac1 , Rhoa
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Gsk3b , Jun , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
erythropoietin signaling pathwayBcl2 , Mapk8 , Pik3r1
extrinsic apoptotic pathwayCasp3
FasL mediated signaling pathwayAkt1 , Casp3 , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Fos , Jun , Mapk1 , Mapk3 , Pik3ca , Pik3r1
forkhead class A signaling pathwayAkt1 , Fos , Jun
G1 phase pathwayCcnd1
G1/S transition pathwayCcnd1
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
glutamate signaling pathwayMapk1 , Mapk3
glycogen biosynthetic pathwayGsk3b
glypican signaling pathwayMapk8 , Mapk9 , Smad2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr2
gonadotropin-releasing hormone signaling pathwayJun , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Raf1
granulocyte-macrophage colony-stimulating factor signaling pathwayFos , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Raf1
Hedgehog signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Tgfb2
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Gsk3b , Kras , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
histone modification pathwayBirc5
Huntington disease pathwayBax , Casp3 , Casp9 , Cycs , Cyct , Tp53
hypertrophic cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
hypoxia inducible factor pathwayAkt1 , Fos , Jun , Smad3 , Smad4
inflammatory response pathwayMapk8
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Casp9 , Cycs , Cyct , Gsk3b , Jun , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Gsk3b , Rac1
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Gsk3b , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
insulin-like growth factor signaling pathwayAkt1 , Bad , Pik3ca , Pik3r1 , Raf1
interleukin-1 signaling pathwayJun , Mapk8 , Pik3ca , Pik3r1
interleukin-12 signaling pathwayFos
interleukin-2 signaling pathwayBcl2 , Fos , Jun , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3r1 , Raf1 , Rhoa
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-27 signaling pathwayTgfb1
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Fos , Jun , Myc , Pik3ca , Pik3r1 , Rac1
intrinsic apoptotic pathwayBad , Bax , Bcl2 , Casp3 , Casp9 , Cycs
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Leishmania infection pathwayFos , Jun , Mapk1 , Mapk3 , Tgfb1 , Tgfb2 , Tgfb3
long term depressionBraf , Gsk3b , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
long term potentiationBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
measles infection pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mismatch repair pathwayMlh1 , Msh2 , Msh3 , Msh6 , Pms1 , Pms2
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Casp3 , Fos , Jun , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Rac1 , Rac2 , Raf1 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cycs , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rhoa
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Cycs , Cyct , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Raf1 , Rhoa , RSA-14-44 , Tgfb1 , Tgfb2 , Tgfb3
myocarditis pathwayCasp3 , Casp9 , Ccnd1 , Cycs , Cyct , Rac1 , Rac2
N-cadherin signaling pathwayAxin1 , Ctnnb1 , Mapk8 , Pik3ca , Pik3r1 , Rac1 , Rhoa
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Bax , Bcl2 , Braf , Gsk3b , Jun , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rhoa , RSA-14-44 , Tp53
NOD-like receptor signaling pathwayMapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
Notch signaling pathwayCcnd1 , Myc
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1
nuclear factor, erythroid 2 like 2 signaling pathwayGsk3b
p38 MAPK signaling pathwayRac1
p53 signaling pathwayAkt1 , Bax , Casp3 , Casp9 , Ccnd1 , Cycs , Cyct , Gsk3b , Mapk8 , Mapk9 , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Ralgds , Smad2 , Smad3 , Smad4 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
Parkinson disease pathwayCasp3 , Casp9 , Cycs , Cyct
phagocytosis pathwayRac1
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rhoa
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
Plasmodium infection pathwayTgfb1 , Tgfb2 , Tgfb3
platelet-derived growth factor signaling pathwayBraf , Fos , Jun , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rhoa
prion diseases pathwayBax , Map2k1 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2 , Braf , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Reelin signaling pathwayAkt1 , Gsk3b , Mapk8 , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Jun , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Tgfb1 , Tgfb2 , Tgfb3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMapk10 , Mapk8 , Mapk9
rheumatoid arthritis disease pathwayFos , Jun , Tgfb1 , Tgfb2 , Tgfb3
Rho/Rac/Cdc42 mediated signaling pathwayJun , Mapk8 , Rac1 , Rhoa
S phase pathwayCcnd1
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bcl2 , Casp9 , Ccnd1 , Cycs , Cyct , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Fos , Jun , Mapk1 , Mapk3 , Mapk8 , Rac1 , Rhoa
syndecan signaling pathwayBax , Casp3 , Mapk1 , Mapk3 , Mapk8 , Rac1 , Rhoa , Tgfb1
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Fos , Gsk3b , Jun , Kras , Map2k1 , Mapk1 , Mapk3 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rhoa , RSA-14-44
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
thyroid cancer pathwayBraf , Ccnd1 , Ctnnb1 , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Myc , Tcf3 , Tcf7 , Tcf7l2 , Tp53
tioguanine pharmacodynamics pathwayRac1
titanium dioxide nanoparticle response pathwayBax , Casp3 , Tp53
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Fos , Jun , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2 , Casp3 , Casp9 , Cycs , Cyct , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tgfb1 , Tgfb2 , Tgfb3
Trail mediated signaling pathwayCasp3 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayAxin1 , Ctnnb1 , Rhoa , Smad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Myc , Rhoa , RSA-14-44 , Smad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Fos , Jun , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Smad2 , Smad3 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
type 2 diabetes mellitus pathwayAkt2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Smad7
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ctnnb1 , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Rhoa
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayApc , Apc2 , Axin1 , Axin2 , Ccnd1 , Ctnnb1 , Gsk3b , Jun , Lef1 , Mapk10 , Mapk8 , Mapk9 , Myc , Rac1 , Rac2 , Rhoa , RSA-14-44 , Smad2 , Smad3 , Smad4 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf7 , Tcf7l2
Wnt signaling, non-canonical pathwayMapk10 , Mapk8 , Mapk9 , Rac1 , Rhoa
Wnt signaling, the planar cell polarity pathwayRac1 , Rhoa
Phenotype Annotations Associated with Genes in the colorectal cancer pathway

References Associated with the colorectal cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: