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Wnt signaling pathways initiated by the Wnt family of secreted glycoproteins play important roles in the control of embryonic development, tissue regeneration, cell polarity, proliferation and cell fate determination. The canonical, beta-catenin dependent pathway is the best understood system. Altered canonical Wnt signaling has been implicated in several conditions, primarily tumorigenesis and bone malformations. Hyperactive Wnt signaling is found in more than 90% of colorectal cancer (CRC). In

Pathway Diagram:

Elsevier Inc. Lrp5 ---> eye defects Lrp5 ---> bone malformations eye defects Lrp5 bone malformations Wnt target genes ---> Colorectal Neoplasms Colorectal Neoplasms Wnt target genes Wnt target genes ---> colorectal cancer pathway colorectal cancer pathway translocated Ctnnb1 Axin1 Axin2 Apc Wls Csnk1g1 Wnt_ligands_secreted Sostdc1 Ndp Sost Crebbp palmitate Wnt_ligands Rnf43 ---| Fzd_receptors Rnf43 ---| Fzd_receptors Znrf3 ---| Fzd_receptors Znrf3 ---| Fzd_receptors sFRPs ---| Wnt_ligands_secreted Wif1 ---| Wnt_ligands_secreted Znrf3 ---| Lrp6 Csnk1g1 --+> Lrp6 Gsk3b --+> Lrp6 RSPOs ---> Wnt signal potentiation Ndp ---> Wnt signal potentiation Gsk3b Lrp6 Kremen2 Kremen1 Wif1 Porcn Lef1 Smarca4 Csnk1a1 Rnf43 Znrf3 Lgr4 Lgr5 RSPOs Btrc Dvls Wnt signal potentiation Dkk members Axin1 ---- Lrp6 Dvls ---- Fzd_receptors sFRPs sFRPs ---- Wnt_ligands_secreted sFRPs ---> Fzd_receptors Fzd_receptors Fzd_receptors ---- sFRPs Axin1 ---- Gsk3b Lgr4 ---- Ndp RSPOs ---> Znrf3 Lrp6 ---- Sost Lrp5 ---- Sost Lrp6 ---- Sostdc1 Dkk members ---- Lrp5 Dkk members ---> Lrp5 Dkk members ---> Lrp6 Dkk members ---- Lrp6 Lrp5 ---- Ndp Lgr4 ---- RSPOs Lgr5 ---- RSPOs Fzd_receptors ---- Wnt_ligands_secreted Lrp5 ---- Wnt_ligands_secreted Kremen2 ---> Dkk members Kremen1 ---> Dkk members Dkk members ---- Kremen1 Dkk members ---- Kremen2 Lrp6 ---- Wnt_ligands_secreted Wif1 ---- Wnt_ligands_secreted translocated Ctnnb1 ---> Wnt target genes Porcn ---> Wnt_ligands Wls ---- Wnt_ligands Wnt_ligands ---> Wnt_ligands_secreted Fzd_receptors ---- Ndp Axin1 ---- Csnk1a1 Tcf_factors Csnk1a1 ---> Axin1 Gsk3b ---> Axin1

Genes in Pathway:

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altered Wnt signaling, canonical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC, WNT signaling pathway regulator JBrowse link 18 27,011,710 27,106,323 RGD:2293188
G Axin1 axin 1 RGD:2293188
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:2293188
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:2293188
G Lrp5 LDL receptor related protein 5 JBrowse link 1 218,816,833 218,920,147 RGD:2293188
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:5490966
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:5490966

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassDkk membersdickkopf homolog 1 (Xenopus laevis)
Functional ClassDvlsdisheveled, dsh homolog family of proteins
Functional ClassFzd_receptorsfrizzled homolog family of proteins
Functional ClassRSPOsRSPOs family of agonists
Functional ClasssFRPssFRP famikly of antagonists
Functional ClassTcf_factorsTcf family of transcription factors
Functional ClassWnt_ligandswingless related family of proteins

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the altered Wnt signaling, canonical pathway

References Associated with the altered Wnt signaling, canonical pathway:

Ontology Path Diagram:

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