ALTERED INSULIN SIGNALING PATHWAY (PW:0000596)

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Description

Type 2 diabetes mellitus (T2D) is reaching epidemic proportions worldwide, yet the genetic underpinnings of the disease continue to be remarkably elusive. The importance and impact of environmental factors such as diet and lifestyle on the susceptibility of the disease only add additional challenges to the identification of genetic causes. While it is known that several pathways important for the maintenance of glucose homeostasis are altered in T2D, less is known about the molecular mech

Pathway Diagram:

Ariadne Genomics Inc. altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway altered insulin responsive facilitative sugar transporter mediated glucose transport pathway Insr Ins2 Irs1 Sh2b2 Irs2 Ins1 Ins1 ---- Insr Irs1 ---- Pik3r1 Irs2 ---- Pik3r1 Grb14 ---| Insr Grb10 ---| Insr Enpp1 ---| Insr Pkcs ---| Insr Pkcs ---| Irs1 Pik3r1 Grb2 ---- Irs2 Irs2 ---- Ptpn11 Grb2 ---- Sos2 Grb2 ---- Shc1 Ptprf ---| Insr Ptpn1 ---| Insr Ptpn11 Ptprf Enpp1 Ptpn1 Pkcs Irs4 Irs3 Grb14 Grb10 Grb2 ---- Sos1 Socs1 ---| Insr Socs6 ---| Insr Socs3 ---| Insr Socs7 ---| Insr Sos1 Sos2 Grb2 Grb2 ---- Irs1 Shc1 Socs7 Socs6 Socs3 Socs1
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altered insulin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:2313694
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:2313694

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwayaltered insulin responsive facilitative sugar transporter mediated glucose transport pathway
Pathwayaltered phosphatidylinositol 3-kinase-Akt signaling pathwaysignaling pathway
Pathwayaltered extracellular signal-regulated Raf/Mek/Erk signaling pathway

Pathway Gene Annotations

Disease Annotations Associated with Genes in the altered insulin signaling pathway
Disease TermsGene Symbols
Acute Kidney InjuryIns2
AdenomaIns2
AIDS Dementia ComplexInsr
AlbuminuriaIns2
Alzheimer DiseaseIns2 , Insr
Bipolar DisorderIns2
Breast NeoplasmsInsr
Carcinoma, Pancreatic DuctalIns2
Carcinoma, Renal CellInsr
CardiomyopathiesInsr
Cardiomyopathy, HypertrophicIns2
ChoriocarcinomaInsr
Diabetes MellitusIns2 , Insr
Diabetes Mellitus, ExperimentalInsr
Diabetes Mellitus, Insulin-Dependent, 2Ins2
Diabetes Mellitus, Insulin-Resistant, with Acanthosis NigricansInsr
Diabetes Mellitus, LipoatrophicInsr
Diabetes Mellitus, Permanent NeonatalIns2
Diabetes Mellitus, Type 1Ins2
Diabetes Mellitus, Type 2Ins2 , Insr
Diabetes, GestationalIns2 , Insr
Diabetic CardiomyopathiesIns2
Diabetic KetoacidosisIns2 , Insr
Diabetic NephropathiesIns2
Diabetic NeuropathiesInsr
Diabetic RetinopathyIns2
Donohue SyndromeInsr
EdemaIns2
Fatty LiverIns2
Glucose IntoleranceIns2 , Insr
Heart ArrestIns2
Heart FailureIns2
HepatitisIns2
Hernias, Diaphragmatic, CongenitalInsr
HyperalgesiaInsr
HyperglycemiaIns2 , Insr
Hyperinsulinemic Hypoglycemia, Familial, 5Insr
HyperinsulinismIns2 , Insr
HyperkalemiaIns2
HyperproinsulinemiaIns2
HypertensionIns2
HypertriglyceridemiaIns2
HyperuricemiaIns2
HypoglycemiaIns2
HypokalemiaIns2
HypotensionIns2
Insulin ResistanceIns2 , Insr
InsulinomaIns2
Kidney Diseases, CysticIns2
Lewy Body DiseaseIns2 , Insr
LipodystrophyInsr
Liver Cirrhosis, ExperimentalIns2
Liver Failure, AcuteIns2
Lung DiseasesInsr
Maturity-Onset Diabetes of the YoungIns2
Maturity-Onset Diabetes of the Young, Type 1Ins2
Maturity-Onset Diabetes of the Young, Type 10Ins2
Memory DisordersIns2
Metabolic DiseasesIns2
Metabolic Syndrome XIns2
Muscular DiseasesIns2
Neural Tube DefectsIns2
Neurocognitive DisordersIns2
ObesityIns2
OsteoarthritisIns2
Pancreatic NeoplasmsIns2
PancreatitisIns2
Panic DisorderIns2
ParalysisIns2
ParesthesiaIns2
Parkinson DiseaseIns2 , Insr
Polycystic Ovary SyndromeIns2
Precancerous ConditionsInsr
Prostatic NeoplasmsIns2 , Insr
Renal InsufficiencyIns2
Renal Insufficiency, ChronicInsr
RhabdomyolysisIns2
Segawa Syndrome, Autosomal RecessiveIns2
SeizuresIns2
SeminomaInsr
Short Bowel SyndromeInsr
Substance-Related DisordersInsr
TachycardiaIns2
Telomeric 22q13 Monosomy SyndromeIns2
Urinary Bladder DiseasesIns2
Ventricular Dysfunction, LeftIns2
Ventricular FibrillationIns2
Ventricular Outflow ObstructionIns2
Weight LossIns2
Pathway Annotations Associated with Genes in the altered insulin signaling pathway

References Associated with the altered insulin signaling pathway:

Ontology Path Diagram:

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