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AMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gamma-regulatory subunits. Humans and rodents have two alpha and beta and three gamma isoforms; some genes are subject to alternative splicing increasing the range of possible heterotrimer combinations. Cellular stresses that inhibit ATP production or increase its consumption change the AMP:ATP r

Pathway Diagram:

Elsevier Inc. P-T172 AMPK targets calmodulin ---- Camkk2 insulin responsive facilitative sugar transporter mediated glucose transport pathway fatty acid beta degradation pathway fatty acid biosynthetic pathway mTOR signaling pathway glycogen biosynthetic pathway gluconeogenesis pathway AMPK alpha PP1 in AMPK ---| AMPK alpha Ppm1e Ppm1f Ppp2ca Ppp2ca ---| AMPK alpha Ppm1e ---| AMPK alpha Ppm1f ---| AMPK alpha Camkk1 --+> AMPK alpha Camkk2 --+> AMPK alpha Lkb1 complex --+> AMPK alpha AMPK beta ---- AMPK gamma AMPK alpha ---- AMPK beta ADP AMP ATP Ca2+ AMPK targets ---| mTOR signaling pathway AMPK targets ---| glycogen biosynthetic pathway AMPK targets ---| gluconeogenesis pathway AMPK targets ---| fatty acid biosynthetic pathway calmodulin AMPK gamma AMPK beta Camkk1 Camkk2 calmodulin ---- Camkk1 AMPK gamma ---- ATP ADP ---- AMPK gamma AMP --+> AMPK gamma Lkb1 complex AMP ---- AMPK gamma AMPK targets --+> fatty acid beta degradation pathway AMPK targets --+> insulin responsive facilitative sugar transporter mediated glucose transport pathway cellular stress ---> AMP cellular stress cellular stress ---> ADP cellular stress ---> ATP AMPK alpha ---> AMPK targets PP1 in AMPK

Genes in Pathway:

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adenosine monophosphate-activated protein kinase (AMPK) signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cab39 calcium binding protein 39 JBrowse link 9 92,834,327 92,895,778 RGD:1600678
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:2311420
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:2311420
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:2311420
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 JBrowse link 10 59,585,023 59,608,180 RGD:2311420
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 JBrowse link 12 39,253,409 39,302,601 RGD:2311420
G Ppm1e protein phosphatase, Mg2+/Mn2+ dependent, 1E JBrowse link 10 74,548,270 74,679,858 RGD:7794756
G Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F JBrowse link 11 88,313,709 88,343,726 RGD:7794756
G Ppp1ca protein phosphatase 1 catalytic subunit alpha JBrowse link 1 219,439,953 219,443,570 RGD:7794757
G Ppp1cb protein phosphatase 1 catalytic subunit beta JBrowse link 6 23,548,507 23,581,136 RGD:7794757
G Ppp1r3d protein phosphatase 1, regulatory subunit 3D JBrowse link 3 173,950,613 173,953,684 RGD:7794757
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:7794757
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:1600678
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:1600678
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 JBrowse link 12 46,316,298 46,326,789 RGD:1600678
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 JBrowse link 2 199,831,990 199,847,623 RGD:1600678
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 JBrowse link 7 140,489,499 140,506,925 RGD:1600678
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 JBrowse link 4 6,559,153 6,799,888 RGD:1600678
G Prkag3 protein kinase AMP-activated non-catalytic subunit gamma 3 JBrowse link 9 81,999,368 82,008,620 RGD:1600678
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:1600678
G Strada STE20-related kinase adaptor alpha JBrowse link 10 94,355,369 94,384,404 RGD:1600678

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupAMPK targetsDownstream targets of AMPK
Small MoleculePT172phosphorylated threonine of AMPK
Functional ClassAMPK alphathe catalytic alpha subunits of the AMPK complex
ComplexLkb1 complexthe main upstream kinase of AMPK is a complex of one catalytic and two regulatory subunits
Functional ClassPP1 in AMPKthe members of phosphatase 1 involved in AMPK regulation
Functional ClassAMPK betathe non-catalytic beta subunits of the AMPK complex
Functional ClassAMPK gammathe non-catalytic gamma subunits of the AMPK complex

Pathway Gene Annotations

Disease Annotations Associated with Genes in the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway
Disease TermsGene Symbols
Acute Lung InjuryPrkaa1
Adenocarcinoma of LungStk11
Alzheimer DiseaseCalm1
Arrhythmogenic Right Ventricular Dysplasia, Familial, 9Prkag2
Autism Spectrum DisorderPrkab2
breast carcinomaStk11
Breast NeoplasmsPrkaa1 , Stk11
Carbohydrate Metabolism, Inborn ErrorsPrkag3
Carcinoma, Non-Small-Cell LungStk11
Carcinoma, Squamous CellStk11
Cardiac Output, LowPpp1ca
CardiomegalyPrkaa2 , Stk11
CardiomyopathiesPrkaa2 , Prkag2
Cardiomyopathy, DilatedPpp1ca
Cardiomyopathy, Familial Hypertrophic, 1Prkag2
Cardiomyopathy, Familial Hypertrophic, 6Prkag2
Cardiomyopathy, HypertrophicPrkag2
Cardiomyopathy, Hypertrophic, FamilialPrkag2
Chromosome 1q21.1 Deletion Syndrome, 1.35-MbPrkab2
Cocaine-Related DisordersCalm1
Colonic NeoplasmsPrkaa1
Colorectal NeoplasmsPpm1e
Deafness, Autosomal Recessive 9Stk11
Depressive Disorder, MajorCalm2
Diabetes ComplicationsPrkaa1
Diabetes Mellitus, Type 2Calm1 , Ppp2ca , Prkaa1 , Prkaa2
Digitorenocerebral SyndromeStk11
Disease ProgressionPrkab1
Dysplastic Nevus SyndromeStk11
Encephalomyelitis, Autoimmune, ExperimentalPrkaa1
Endometrial NeoplasmsStk11
Epilepsies, MyoclonicStk11
Epileptic Encephalopathy, Early Infantile, 16Stk11
Fatty LiverPrkaa1
Glucose IntolerancePrkaa1 , Prkaa2
Glycogen Storage DiseasePrkag2
Glycogen Storage Disease of Heart, Lethal CongenitalPrkag2
Heart DiseasesPpp2ca
Heart FailurePpp1ca , Ppp2ca
Huntington DiseasePrkaa1
Hypertrophy, Left VentricularStk11
Insulin ResistancePrkaa1 , Prkaa2 , Stk11
Intestinal PolyposisStk11
Lipid Metabolism, Inborn ErrorsPrkag3
Liver Neoplasms, ExperimentalPpp2ca
Long QT Syndrome 1Calm3
Lung NeoplasmsStk11
Lymphatic MetastasisStk11
Male Germ Cell TumorStk11
Marijuana AbuseCalm1
MelanomaPpp2ca , Prkag2 , Stk11
Melanoma, Cutaneous MalignantStk11
Melanoma, Cutaneous Malignant, Susceptibility To, 1Ppp2ca , Prkag2 , Stk11
Myocardial IschemiaPpp2ca
Myoclonic Epilepsy, Familial InfantileStk11
Neoplastic Syndromes, HereditaryStk11
Nervous System DiseasesCamkk1
Noonan syndrome-like disorder with loose anagen hair 2Ppp1cb
Ovarian NeoplasmsStk11
pancreatic carcinoma Stk11
Pancreatic NeoplasmsStk11
Parkinson DiseasePpp2ca
Peutz-Jeghers SyndromeStk11
Phencyclidine AbuseCalm1
Polyhydramnios, Megalencephaly, and Symptomatic EpilepsyStrada
Polymorphic Catecholergic Ventricular TachycardiaCalm1
Prostatic Intraepithelial NeoplasiaStk11
Prostatic NeoplasmsPpp2ca
Romano-Ward SyndromeCalm3
Smith-Magenis SyndromePpm1e , Strada
Squamous Cell Carcinoma of the LungStk11
Stomach NeoplasmsPrkaa1 , Prkab1
StrokePrkaa2 , Prkag2
Testicular Germ Cell TumorStk11
Tumor Predisposition SyndromeStk11
Uterine Cervical NeoplasmsStk11
Ventricular tachycardia, catecholaminergic polymorphic, 1Calm1
Ventricular tachycardia, catecholaminergic polymorphic, 4Calm1
Weight GainCalm1
Wolff-Parkinson-White SyndromePrkag2
Pathway Annotations Associated with Genes in the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayCalm1
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayCab39 , Calm1 , Calm2 , Calm3 , Camkk1 , Camkk2 , Ppm1e , Ppm1f , Ppp1ca , Ppp1cb , Ppp1r3d , Ppp2ca , Prkaa1 , Prkaa2 , Prkab1 , Prkab2 , Prkag1 , Prkag2 , Prkag3 , Stk11 , Strada
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayCalm1
Alzheimer disease pathwayCalm1 , Calm2 , Calm3
amiodarone pharmacodynamics pathwayCalm1
amlodipine pharmacodynamics pathwayCalm1
ataxia telangiectasia-mutated (ATM) signaling pathwayPpp2ca
atenolol pharmacodynamics pathwayCalm1
autophagy pathwayPrkaa1 , Prkaa2
betaxolol pharmacodynamics pathwayCalm1
bisoprolol pharmacodynamics pathwayCalm1
Bone morphogenetic proteins signaling pathwayPpp1ca
bupranolol drug pathwayCalm1
bupranolol pharmacodynamics pathwayCalm1
calcium/calcium-mediated signaling pathwayCalm1 , Calm2 , Calm3
calcium/calmodulin dependent kinase 2 signaling pathwayCalm1 , Calm2 , Calm3 , Ppm1e , Ppm1f , Ppp2ca
carvedilol pharmacodynamics pathwayCalm1
diltiazem pharmacodynamics pathwayCalm1
disopyramide pharmacodynamics pathwayCalm1
dobutamine pharmacodynamics pathwayCalm1
dopamine signaling pathwayPpp1ca , Ppp1cb , Ppp2ca
esmolol pharmacodynamics pathwayCalm1
flecainde pharmacodynamics pathwayCalm1
follicle-stimulating hormone signaling pathwayPpp1ca
fosphenytoin pharmacodynamics pathwayCalm1
glioma pathwayCalm1 , Calm2 , Calm3
glycogen biosynthetic pathwayPpp1ca , Ppp1cb , Ppp1r3d
glycogen degradation pathwayCalm1 , Calm2 , Calm3 , Ppp1ca , Ppp1cb , Ppp1r3d
gonadotropin-releasing hormone signaling pathwayCalm1 , Calm2 , Calm3
hepatitis C virus infection pathwayPpp2ca
histamine signaling pathway, immunologicalPpp1ca
hypertrophic cardiomyopathy pathwayPrkaa1 , Prkaa2 , Prkab1 , Prkab2 , Prkag1 , Prkag2 , Prkag3
ibutilide pharmacodynamics pathwayCalm1
insulin responsive facilitative sugar transporter mediated glucose transport pathwayCalm1 , Calm2 , Calm3
insulin signaling pathwayCalm1 , Calm2 , Calm3 , Ppp1ca , Ppp1cb , Ppp1r3d , Prkaa1 , Prkaa2 , Prkab1 , Prkab2 , Prkag1 , Prkag2 , Prkag3
isoprenaline pharmacodynamics pathwayCalm1
isradipine pharmacodynamics pathwayCalm1
levobunolol pharmacodynamics pathwayCalm1
lidocaine pharmacodynamics pathwayCalm1
long term depressionPpp2ca
long term potentiationCalm1 , Calm2 , Calm3 , Ppp1ca , Ppp1cb
luteinizing hormone signaling pathwayPpp1ca
metoprolol pharmacodynamics pathwayCalm1
mexiletine pharmacodynamics pathwayCalm1
mRNA decay pathwayPpp2ca
mTOR signaling pathwayCab39 , Prkaa1 , Prkaa2 , Stk11 , Strada
Mycobacterium tuberculosis infection pathwayCalm1 , Calm2 , Calm3
N-cadherin signaling pathwayCalm1 , Calm2 , Calm3
nadolol pharmacodynamics pathwayCalm1
nebivolol pharmacodynamics pathwayCalm1
neurotrophic factor signaling pathwayCalm1 , Calm2 , Calm3
nifedipine pharmacodynamics pathwayCalm1
nimodipine pharmacodynamics pathwayCalm1
nisoldipine pharmacodynamics pathwayCalm1
nitrendipine pharmacodynamics pathwayCalm1
p38 MAPK signaling pathwayCalm1 , Calm2 , Calm3
p53 signaling pathwayPpp2ca
penbutolol pharmacodynamics pathwayCalm1
phenytoin pharmacodynamics pathwayCalm1
phosphatidylinositol 3-kinase signaling pathwayCalm1 , Calm2 , Calm3
phosphatidylinositol 3-kinase-Akt signaling pathwayPpp2ca
pindolol pharmacodynamics pathwayCalm1
platelet-derived growth factor signaling pathwayPpp2ca
procainamide pharmacodynamics pathwayCalm1
propranolol pharmacodynamics pathwayCalm1
quinidine pharmacodynamics pathwayCalm1
serotonin signaling pathway via receptors engaging G alphas protein familyPpp1ca
sotalol pharmacodynamics pathwayCalm1
timolol pharmacodynamics pathwayCalm1
transforming growth factor-beta Smad dependent signaling pathwayPpp1ca , Ppp2ca
transforming growth factor-beta superfamily mediated signaling pathwayPpp2ca
Trypanosoma cruzi infection pathwayPpp2ca
type II interferon signaling pathwayCalm1 , Calm2 , Calm3
vascular endothelial growth factor signaling pathwayCalm1 , Calm2 , Calm3 , Camkk2 , Prkaa1 , Prkaa2 , Prkab1 , Prkag1
verapamil pharmacodynamics pathwayCalm1
visual phototransduction pathwayCalm1 , Calm2 , Calm3
Wnt signaling pathwayPpp2ca

References Associated with the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway:

Ontology Path Diagram:

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