RENIN-ANGIOTENSIN CASCADE PATHWAY (PW:0000492)

View Ontology Report

Description

Renin-angiotensin system (RAS) signaling pathway is well known for its cardiovascular roles primarily via the circulating or 'classical' route and also, has become recognized as a complex system with pleiotropic effects that engages both the circulating and the local or 'tissue' routes. Originally viewed as solely endocrine, the system is now regarded as an endocrine, paracrine and autocrine one producing an array of diverse and many times opposing actions. Underlying the system's ability of pro

Pathway Diagram:

Ariadne Genomics Inc. Ren Agtr2 Agtr1a Agtr1b Mas1 Lnpep angiotensin III signaling via AT2 receptor angiotensin III signaling pathway angiotensin (1-7) signaling pathway angiotensin IV signaling pathway angiotensin II signaling pathway angiotensin II signaling via AT2 receptor angiotensin II signaling via AT1 receptor Enpep Anpep Mme Ace2 Ace renin receptor mediated intracellular signaling angiotensin IV signaling pathway ---> cognition AgtIII ---- Agtr1a Renbp ---| Ren Renbp Agt ---> AgtI AgtIII ---- Agtr2 cognition AgtII ---- Agtr1b AgtIV ---- Lnpep AgtII ---- Agtr2 AgtI ---> AgtII Igf2r ---- Ren angiotensin III signaling via AT1 receptor ---> cell proliferation vasodilation AgtII ---- Agtr1a angiotensin III signaling via AT2 receptor ---> vasodilation angiotensin II signaling via AT2 receptor ---> vasodilation Atp6ap2 ---- Ren Cma1 Atp6ap2 ---> renin receptor mediated intracellular signaling Igf2r cell proliferation vasoconstriction angiotensin II signaling via AT1 receptor ---> cell proliferation Igf2r ---> complex internalization complex internalization AgtII ---> AgtIII Agt AgtI ---> Agt(1-7) AgtIII ---> AgtIV AgtII ---> Agt(1-7) AgtIII ---- Agtr1b AgtI Agt(1-7) AgtIII AgtIV AgtII Ren ---- Renbp Ren ---> renin receptor mediated intracellular signaling angiotensin III signaling via AT1 receptor angiotensin III signaling via AT1 receptor ---> vasoconstriction angiotensin II signaling via AT1 receptor ---> vasoconstriction angiotensin (1-7) signaling pathway ---> vasodilation Atp6ap2 Agt(1-7) ---- Mas1
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Genes in Pathway:

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renin-angiotensin cascade pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1581742
RGD:1581953
RGD:6907045
G Ace2 angiotensin I converting enzyme 2 JBrowse link X 32,050,734 32,095,860 RGD:1581742
RGD:1581931
RGD:6907045
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581651
RGD:1581742
RGD:1582105
RGD:6907045
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1581847
RGD:6907045
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1581847
RGD:6907045
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1581855
RGD:6907045
G Anpep alanyl aminopeptidase, membrane JBrowse link 1 141,561,364 141,604,249 RGD:1581649
RGD:6907045
G Atp6ap2 ATPase H+ transporting accessory protein 2 JBrowse link X 11,137,889 11,164,854 RGD:5132617
G Cma1 chymase 1 JBrowse link 15 34,601,037 34,603,819 RGD:1581742
RGD:6907045
G Cpa3 carboxypeptidase A3 JBrowse link 2 105,016,798 105,047,989 RGD:6907045
G Ctsa cathepsin A JBrowse link 3 161,298,750 161,304,627 RGD:6907045
G Ctsg cathepsin G JBrowse link 15 35,107,333 35,113,678 RGD:6907045
G Enpep glutamyl aminopeptidase JBrowse link 2 233,667,253 233,743,866 RGD:1581649
RGD:1581742
RGD:6907045
G Igf2r insulin-like growth factor 2 receptor JBrowse link 1 48,176,095 48,264,482 RGD:1581738
RGD:1581739
G Lnpep leucyl and cystinyl aminopeptidase JBrowse link 1 59,289,392 59,384,540 RGD:1581849
RGD:1582105
RGD:6907045
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor JBrowse link 1 48,076,761 48,108,218 RGD:1581849
RGD:1581931
RGD:6907045
G Mcpt8l2 mast cell protease 8-like 2 JBrowse link 15 34,622,126 34,625,079 RGD:6907045
G Mcpt8l3 mast cell protease 8-like 3 JBrowse link 15 34,667,266 34,670,303 RGD:6907045
G Mme membrane metallo-endopeptidase JBrowse link 2 153,799,203 153,880,910 RGD:1581742
RGD:1581931
RGD:1581953
RGD:6907045
G Nln neurolysin JBrowse link 2 34,086,970 34,185,835 RGD:6907045
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:1581651
RGD:1581738
RGD:1581739
RGD:1581742
RGD:6907045
G Renbp renin binding protein JBrowse link X 156,854,490 156,863,548 RGD:5132613
G Rnpep arginyl aminopeptidase JBrowse link 13 52,092,863 52,124,006 RGD:1581649
G Thop1 thimet oligopeptidase 1 JBrowse link 7 11,501,145 11,513,576 RGD:6907045
angiotensin (1-7) signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1581953
RGD:1598433
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581938
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor JBrowse link 1 48,076,761 48,108,218 RGD:1581931
RGD:1581938
G Mme membrane metallo-endopeptidase JBrowse link 2 153,799,203 153,880,910 RGD:1581742
RGD:1581931
RGD:1581953
angiotensin II signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1581742
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1579760
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:629553
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1566502
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:1582323
G Cma1 chymase 1 JBrowse link 15 34,601,037 34,603,819 RGD:1581745
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1600094
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:1580992
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:1581775
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:1642674
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1581825
RGD:2316188
RGD:5133683
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1581825
G Agtrap angiotensin II receptor-associated protein JBrowse link 5 164,888,069 164,898,387 RGD:2314353
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 JBrowse link 1 166,459,062 166,525,200 RGD:2316188
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5133417
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5133417
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:1581847
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:1581847
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:5133417
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:5133417
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:5133417
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:5133417
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:5133683
RGD:6478796
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:5133418
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:6478796
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582434
RGD:1582435
RGD:7401256
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1581825
RGD:7401256
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 JBrowse link 5 152,447,348 152,458,005 RGD:5133679
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:5133675
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:5133679
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:7401256
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:7401256
G Mtus1 microtubule associated scaffold protein 1 JBrowse link 16 54,240,892 54,386,131 RGD:5133679
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:5133675
G Slc9a6 solute carrier family 9 member A6 JBrowse link X 158,979,081 159,045,019 RGD:5133679
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:5133679
G Zbtb16 zinc finger and BTB domain containing 16 JBrowse link 8 52,980,226 53,146,765 RGD:5133679
angiotensin III signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582124
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1582124
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1582124
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1582124
G Enpep glutamyl aminopeptidase JBrowse link 2 233,667,253 233,743,866 RGD:1581649
angiotensin III signaling pathway via AT1 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582152
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1582152
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1582152
angiotensin III signaling pathway via AT2 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582118
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1582118
angiotensin IV signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582105
G Anpep alanyl aminopeptidase, membrane JBrowse link 1 141,561,364 141,604,249 RGD:1581649
G Lnpep leucyl and cystinyl aminopeptidase JBrowse link 1 59,289,392 59,384,540 RGD:1581864
RGD:1582105
G Rnpep arginyl aminopeptidase JBrowse link 13 52,092,863 52,124,006 RGD:1581649
angiotensin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1566511

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ProteinAgt(1-7)angiotensinogen derived peptide
ProteinAgtIVangiotensinogen derived peptide
ProteinAgtIIIangiotensinogen derived peptide
ProteinAgtIIangiotensinogen derived peptide

Pathway Gene Annotations

Disease Annotations Associated with Genes in the renin-angiotensin cascade pathway
Disease TermsGene Symbols
Abortion, SpontaneousAce2 , Agtr1a
Acute Kidney InjuryAce
AdenocarcinomaAce
AIDS-Associated NephropathyAgtr1a , Agtr2
AlbuminuriaAce , Agt , Ren
AlkalosisAgt
Allanson Pantzar McLeod SyndromeAce , Agt , Agtr1a , Ren
Alveolitis, Extrinsic AllergicAce
Alzheimer DiseaseAce , Agt , Agtr1a , Igf2r , Mme
Amyotrophic Lateral SclerosisIgf2r
AnaphylaxisAgt , Cma1
AnemiaAce , Agt , Ren
Aneurysm, DissectingAgt
Angina, UnstableAce , Agt , Agtr1a
Angiotensin I-Converting Enzyme, Benign Serum IncreaseAce
Anti-Glomerular Basement Membrane DiseaseAgt , Agtr1a
AnuriaAgt
Aortic AneurysmAgt
Aortic Aneurysm, AbdominalAce , Ace2 , Agt , Agtr1a
Aortic CalcificationAgt
Aortic CoarctationAce
Arrhythmias, CardiacAce , Agt , Agtr1a
Arteriovenous FistulaAce
Arthritis, ExperimentalAce
AsthmaAce , Agtr1a , Agtr2 , Cma1
AtherosclerosisAgt
Atrial FibrillationAce , Agt , Agtr1a , Ren
Autistic DisorderAce
AzotemiaRen
Bartter SyndromeRen
Behcet SyndromeAce
BerylliosisAce
Bipolar DisorderAce , Agt
BradycardiaAgt
Brain IschemiaAce
Breast NeoplasmsAce , Agt , Agtr1a , Igf2r , Lnpep , Mme
Bronchiolitis ObliteransAce
Carcinoma in SituAce , Igf2r
Carcinoma, EndometrioidLnpep
Carcinoma, HepatocellularAce , Igf2r
Carcinoma, LobularAgtr2
Carcinoma, Pancreatic DuctalAce , Ace2 , Agtr1a
Carcinoma, Renal CellAgtr1a , Agtr2 , Lnpep
Cardiac FibrosisAce2
CardiomegalyAce , Agt , Agtr1a , Agtr1b , Cma1 , Ren
CardiomyopathiesAgt
Cardiomyopathy, AlcoholicAce , Agt
Cardiomyopathy, DilatedAce , Agt , Agtr1a , Agtr2 , Mas1 , Renbp
Cardiomyopathy, HypertrophicAce , Agt , Cma1
Cardiovascular AbnormalitiesAgt
Cardiovascular DiseasesAce , Agt
Carotid Artery DiseasesAce , Agt , Agtr1a
Carotid Artery InjuriesAgtr1a
CatalepsyAgt
Cerebral Amyloid AngiopathyMme
Cerebral HemorrhageAce
Cerebral InfarctionAce
Cerebrovascular DisordersAgt , Agtr1a
Charcot-Marie-Tooth Disease, Axonal, Type 2TMme
Chemotherapy-Induced Febrile NeutropeniaAce
CholestasisAgt
Chronic Intermittent HypoxiaAce , Agt
Cognition DisordersAgt
Congenital Hepatic FibrosisAce
Corneal NeovascularizationAgt , Agtr1a
Coronary Artery DiseaseAce , Agt , Agtr1a
Coronary DiseaseAce , Ace2 , Agtr1a
Coronary RestenosisAce
Coronavirus InfectionsAce
CoughAce
Craniofacial AbnormalitiesAtp6ap2
Crohn DiseaseAgt
Cryopyrin-Associated Periodic SyndromesMme
Death, SuddenAce , Agt
Dermatitis, AtopicCma1
Diabetes Mellitus, ExperimentalAce , Ace2 , Agt , Agtr2 , Cma1 , Igf2r , Mas1 , Ren
Diabetes Mellitus, Type 1Ace , Igf2r
Diabetes Mellitus, Type 2Ace , Agt , Agtr2 , Igf2r , Lnpep
Diabetic CardiomyopathiesAce , Ace2 , Agtr2
Diabetic NephropathiesAce , Ace2 , Agt , Agtr1a , Agtr2 , Lnpep , Ren
Diabetic NeuropathiesMme
Diabetic RetinopathyAce , Ace2 , Agt , Agtr1a
Drug HypersensitivityAce
Drug OverdoseAgt
Drug-Related Side Effects and Adverse ReactionsRen
Ductus Arteriosus, PatentAgtr1a
Endometrial NeoplasmsLnpep
Endomyocardial FibrosisAce , Ace2 , Agt
EndotoxemiaAce , Agtr2
Epilepsy, Temporal LobeAgt
Erectile DysfunctionAgt
Fabry DiseaseAce
Familial Cerebral Cavernous MalformationAce
Fatigue Syndrome, ChronicRen
Fetal DeathAce
Fetal Growth RetardationAce , Agt , Agtr1a , Agtr2 , Ren
FibrosisAgt , Agtr1a , Agtr2 , Atp6ap2 , Ren
Gallbladder NeoplasmsAce
Gaucher DiseaseAce
Genetic Predisposition to DiseaseAce
GlaucomaAce2 , Mas1
GlomerulonephritisAce , Agt , Agtr2
Glomerulonephritis, IGAAce , Agt , Agtr1a , Agtr2
Glomerulonephritis, MembranousMme
GlomerulosclerosisAce , Agtr1a , Agtr2
Glomerulosclerosis, Focal SegmentalAgt , Agtr1a , Agtr2
Glycogen Storage Disease Type VAce
GranulomaCma1
Heart Defects, CongenitalCma1
Heart DiseasesAgt
Heart FailureAce , Agt , Agtr1a , Agtr2 , Mas1 , Ren
HemorrhageAgt , Ren
Hepatitis, AlcoholicAgt
Hernia, DiaphragmaticAgt , Agtr1b
Hernias, Diaphragmatic, CongenitalAce , Agtr2 , Igf2r
Huntington DiseaseAgtr1a
HydronephrosisAgt
Hydrops FetalisCtsa
HyperaldosteronismAgtr1b
HyperalgesiaAgt
HyperemiaAgt
HyperinsulinismAgt , Agtr1a
HyperoxiaAce
HypersensitivityAce , Agt
HypertensionAce , Ace2 , Agt , Agtr1a , Agtr1b , Agtr2 , Cma1 , Mas1 , Ren , Rnpep
Hypertension, EssentialAgt , Agtr1a
Hypertension, MalignantAgt , Ren
Hypertension, PortalRen
Hypertension, Pregnancy-InducedAce , Ace2 , Agt
Hypertension, PulmonaryAce , Agt , Agtr1a
Hypertension, RenalAgt , Agtr1a
Hypertension, RenovascularAce , Agtr1a , Agtr1b , Agtr2 , Ren
Hypertensive NephropathyAgt , Agtr1a
HypertrophyAgt
Hypertrophy, Left VentricularAce , Ace2 , Agt , Agtr1a , Agtr2 , Cma1 , Ren
Hypertrophy, Right VentricularAce
Hyperuricemic Nephropathy, Familial Juvenile 2Ren
Hyperuricemic Nephropathy, Familial Juvenile, 1Ren
HypoglycemiaAgtr2
HypokalemiaAgt
HypotensionAce , Agt , Ren
Hypoxia-Ischemia, BrainAgtr2
Infant, Premature, DiseasesAce
Infarction, Middle Cerebral ArteryAce , Ace2 , Agt
Infertility, MaleAce
InflammationAgt , Agtr1a , Agtr2
Inflammatory Bowel DiseasesAgt
Insulin ResistanceAce , Agtr2
Intellectual DisabilityAgtr2
Intracranial AneurysmAce
IschemiaRen
Ischemic Attack, TransientAgt
Juvenile GoutRen
Kidney DiseasesAce , Agt , Agtr1a , Ren
Kidney Failure, ChronicAce , Agt , Agtr2
Kidney Reperfusion InjuryAce , Ace2
LeiomyomaLnpep
LeukemiaAce
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveAce , Agt
LeukostasisAce
Lewy Body DiseaseIgf2r
Liddle SyndromeRen
Liver CirrhosisAgt , Ren
Liver Cirrhosis, BiliaryAce , Ace2 , Agt , Mas1 , Ren
Liver Cirrhosis, ExperimentalAce2 , Agt , Agtr1a , Enpep , Igf2r , Mas1 , Mme
Liver NeoplasmsIgf2r
Liver Neoplasms, ExperimentalIgf2r
Lung DiseasesAce , Ace2 , Agtr1a , Igf2r
Lung Diseases, InterstitialCma1
Lung InjuryMme
Lung NeoplasmsAce , Igf2r
Lupus Erythematosus, SystemicAce , Agtr2
Lysosomal Storage DiseasesCtsa
Mammary Neoplasms, ExperimentalAgt , Agtr1a , Agtr2 , Lnpep , Rnpep
Meconium Aspiration SyndromeAgt , Agtr2
Melanoma, Cutaneous MalignantAgt
Memory DisordersAce , Lnpep
Meningococcal InfectionsAce
Mental Retardation, X-LinkedAgtr2
Mental Retardation, X-Linked, with EpilepsyAtp6ap2
Metabolic Syndrome XAgt , Agtr1a
Microvascular Complications of Diabetes, Susceptibility To, 1Ace
Microvascular Complications of Diabetes, Susceptibility To, 2Ace
Microvascular Complications of Diabetes, Susceptibility To, 3Ace
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 4Ace
Microvascular Complications of Diabetes, Susceptibility To, 6Ace
Microvascular Complications of Diabetes, Susceptibility To, 7Ace
Mitral Valve ProlapseAce , Agt
Multiple MyelomaAce
Myocardial InfarctionAce , Ace2 , Agt , Agtr1a , Ren
Myocardial IschemiaAgt
Myocardial Reperfusion InjuryAgt , Agtr1a
MyocarditisAce , Cma1
NecrosisAgt
NeointimaAgt
Neoplasm MetastasisAce , Agtr1a , Agtr2
NephritisAce , Agtr1a
NephrosclerosisAce
NephrosisAce , Agt , Ren
Nephrosis, Puromycin AminonucleosideAce , Agt , Ren
Nephrotic SyndromeAce
Neuraminidase Deficiency with Beta-Galactosidase DeficiencyCtsa
Non-alcoholic Fatty Liver DiseaseAce
Nonarteritic Anterior Ischemic Optic NeuropathyAce
ObesityAce , Agt , Agtr2 , Ren
Ocular HypotensionAce
OsteoporosisAce , Ren
OtosclerosisAgt
Ovarian CystsAgtr2
Ovarian NeoplasmsLnpep
PainAce
Pancreatic NeoplasmsAce , Agtr2
Parkinson DiseaseAce , Agtr1a , Igf2r
Parkinsonism with Spasticity, X-LinkedAtp6ap2
Peptic Ulcer HemorrhageAgt
Peritoneal FibrosisAce
Pituitary NeoplasmsAgtr1a
Placental InsufficiencyAgtr1a
PneumoniaAce
Pneumonia, AspirationAce
Pneumonia, ViralAce
Polycystic Kidney, Autosomal RecessiveAce
PolycythemiaAce
PolyhydramniosLnpep
Postoperative Cognitive DysfunctionAgtr1a , Agtr1b
Pre-EclampsiaAce , Agt
Precancerous ConditionsAce
Prediabetic StateAgt
Prenatal Exposure Delayed EffectsAgtr1b
Prostatic NeoplasmsAce , Igf2r , Mme
ProteinuriaAce , Agt , Agtr1a , Ren
PsoriasisRen
Psychoses, Substance-InducedAce
Pulmonary Disease, Chronic ObstructiveAce , Cma1
Pulmonary EdemaAgt
Pulmonary FibrosisAce , Ace2 , Agt , Agtr1a , Agtr2 , Cma1
Purpura, Schoenlein-HenochAce , Agt
PyelonephritisAce
Radiation Injuries, ExperimentalAce , Agtr1a , Agtr2
Renal FibrosisAce
Renal InsufficiencyAce , Agt , Mme
Renal Insufficiency, ChronicAgtr1a , Agtr2
Renal Tubular DysgenesisAce , Agt , Agtr1a , Ren
Reoviridae InfectionsIgf2r
Reperfusion InjuryAce , Agt , Agtr2 , Ctsg
Respiratory Distress Syndrome, AdultAce
Respiratory Tract DiseasesAce
Retina Reperfusion InjuryRen
Retinal VasculitisAgt
Retinopathy of PrematurityAgt
Rhinitis, AllergicAce
Rhinitis, Allergic, SeasonalCma1
SarcoidosisAce , Agtr1a , Cma1
Sciatic NeuropathyAgt
Scleroderma, DiffuseAgt
Scleroderma, SystemicAce , Agt
Segmental GlomerulosclerosisAce
SeizuresAgt
Severe Acute Respiratory SyndromeAce
Sick Sinus SyndromeAgt
Sleep Apnea, ObstructiveAce
Smith-Magenis SyndromeAce
SPINOCEREBELLAR ATAXIA 43Mme
Spondylitis, AnkylosingAce
Staphylococcal InfectionsAce
Stomach NeoplasmsAce , Agtr2
Stomach UlcerAgt
StrokeAce , Agt , Agtr2
Substance Withdrawal SyndromeRen
ThrombosisAce2 , Agt , Mas1
Ureteral ObstructionAce
Urinary Bladder NeoplasmsAnpep
Urogenital AbnormalitiesAgtr2
UveitisAce
Vascular RemodelingAgt
Vascular System InjuriesAce , Agtr2
Venous ThromboembolismAce
Ventricular Dysfunction, LeftAgt
Ventricular FibrillationAce
Ventricular RemodelingAce , Ace2 , Agtr1a
Vesico-Ureteral RefluxAgtr1a , Agtr2
Water-Electrolyte ImbalanceAgtr1b
Weight GainAce
Wilms TumorIgf2r
Pathway Annotations Associated with Genes in the renin-angiotensin cascade pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAgtr1a
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAgtr1a
Alzheimer disease pathwayMme
amino sugar metabolic pathwayRenbp
amiodarone pharmacodynamics pathwayAgtr1a
amlodipine pharmacodynamics pathwayAgtr1a
angiotensin (1-7) signaling pathwayAce , Agt , Mas1 , Mme
angiotensin II signaling pathwayAce , Agt , Agtr1a , Agtr1b , Agtr2 , Cma1
angiotensin II signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b
angiotensin II signaling pathway via AT2 receptorAgt , Agtr2
angiotensin III signaling pathwayAgt , Agtr1a , Agtr1b , Agtr2 , Enpep
angiotensin III signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b
angiotensin III signaling pathway via AT2 receptorAgt , Agtr2
angiotensin IV signaling pathwayAgt , Anpep , Lnpep , Rnpep
angiotensin signaling pathwayAgt
apelin signaling pathwayAce2
atenolol pharmacodynamics pathwayAgtr1a
benazepril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
benazepril pharmacokinetics pathwayAce
betaxolol pharmacodynamics pathwayAgtr1a
bisoprolol pharmacodynamics pathwayAgtr1a
bupranolol drug pathwayAgtr1a
bupranolol pharmacodynamics pathwayAgtr1a
calcium/calcium-mediated signaling pathwayAgtr1a , Agtr1b
candesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
captopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
carvedilol pharmacodynamics pathwayAgtr1a
cilazapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
cilazapril pharmacokinetics pathwayAce
diltiazem pharmacodynamics pathwayAgtr1a
disopyramide pharmacodynamics pathwayAgtr1a
dobutamine pharmacodynamics pathwayAgtr1a
enalapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
enalapril pharmacokinetics pathwayAce
Entamoeba histolyca infection pathwayCtsg , Mcpt8l2 , Mcpt8l3
eprosartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
esmolol pharmacodynamics pathwayAgtr1a
flecainde pharmacodynamics pathwayAgtr1a
forasartsn pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
fosinopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
fosinopril pharmacokinetics pathwayAce
fosphenytoin pharmacodynamics pathwayAgtr1a
french type sialuria disease pathwayRenbp
G protein mediated signaling pathway via Galpha12/Galpha13 familyAgtr1a
G protein mediated signaling pathway via Galphai familyAgtr2
G protein mediated signaling pathway via Galphaq familyAgtr1a , Agtr1b
glutathione metabolic pathwayAnpep
glutathione synthase deficiency pathwayAnpep
glutathionuria disease pathwayAnpep
hypertrophic cardiomyopathy pathwayAce
ibutilide pharmacodynamics pathwayAgtr1a
insulin responsive facilitative sugar transporter mediated glucose transport pathwayLnpep
irbesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
isoprenaline pharmacodynamics pathwayAgtr1a
isradipine pharmacodynamics pathwayAgtr1a
kallikrein-kinin cascade pathwayAce
levobunolol pharmacodynamics pathwayAgtr1a
lidocaine pharmacodynamics pathwayAgtr1a
lisinopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
long term potentiationAgt , Lnpep
losartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
metoprolol pharmacodynamics pathwayAgtr1a
mexiletine pharmacodynamics pathwayAgtr1a
moexipril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
moexipril pharmacokinetics pathwayAce
myocardial infarction pathwayAgt
nadolol pharmacodynamics pathwayAgtr1a
nebivolol pharmacodynamics pathwayAgtr1a
nifedipine pharmacodynamics pathwayAgtr1a
nimodipine pharmacodynamics pathwayAgtr1a
nisoldipine pharmacodynamics pathwayAgtr1a
nitrendipine pharmacodynamics pathwayAgtr1a
nucleotide sugar metabolic pathwayRenbp
olmesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
penbutolol pharmacodynamics pathwayAgtr1a
perindopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
phenytoin pharmacodynamics pathwayAgtr1a
pindolol pharmacodynamics pathwayAgtr1a
procainamide pharmacodynamics pathwayAgtr1a
propranolol pharmacodynamics pathwayAgtr1a
quinapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
quinapril pharmacokinetics pathwayAce
quinidine pharmacodynamics pathwayAgtr1a
ramipril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
ramipril pharmacokinetics pathwayAce
renin-angiotensin cascade pathwayAce , Ace2 , Agt , Agtr1a , Agtr1b , Agtr2 , Anpep , Atp6ap2 , Cma1 , Cpa3 , Ctsa , Ctsg , Enpep , Igf2r , Lnpep , Mas1 , Mcpt8l2 , Mcpt8l3 , Mme , Nln , Ren , Renbp , Rnpep , Thop1
sialic acid storage disease pathwayRenbp
sotalol pharmacodynamics pathwayAgtr1a
spirapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
spirapril pharmacokinetics pathwayAce
systemic lupus erythematosus pathwayCtsg , Mcpt8l2 , Mcpt8l3
Tay-Sachs disease pathwayRenbp
telmisartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
timolol pharmacodynamics pathwayAgtr1a
trandolapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
trandolapril pharmacokinetics pathwayAce
Trypanosoma brucei infection pathwayThop1
Trypanosoma cruzi infection pathwayAce
valsartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
verapamil pharmacodynamics pathwayAgtr1a
Phenotype Annotations Associated with Genes in the renin-angiotensin cascade pathway

References Associated with the renin-angiotensin cascade pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: