TRANSFORMING GROWTH FACTOR-BETA SMAD DEPENDENT SIGNALING PATHWAY (PW:0000490)

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Description

Transforming growth factor-beta superfamily mediated pathways are central regulators of proliferation and survival, migration and differentiation, angiogenesis, embryonic development and wound healing. The superfamily of ligands can be divided into two main groups: the Tgf-b/activin and the bone morphogenetic protein (BMP)/growth and differentiation factor (GDF) - both can be further subdivided. The serine/threonine kinase receptor superfamily is represented by the type I and II receptors that c

Pathway Diagram:

Elsevier Inc. Dcn A2m Tgfbr3 Smad7 Fkbp1a Smad4 Smad3 ---- Zfyve9 Smad2 Smad3 Translocated Smad Zfyve9 Tgfb1 Tgfbr1 Tgfbr2 Smad7 ---| Tgfbr1 Smurf2 Smurf1 Tgf-beta target genes Transcription factors/co-activators Smad2 ---- Smad4 Fkbp1a ---| Tgfbr1 A2m ---| Tgfb1 Tgfbr2 --+> Tgfbr1 Smad7 ---| Tgfbr1 Smad3 ---- Smad4 Smad2 ---- Zfyve9 Tgfbr1 ---- Zfyve9 Tgfbr1 --+> Smad2 Tgfbr1 --+> Smad3 Tgfb1 ---- Tgfbr1 Tgfb1 ---- Tgfbr3 Dcn ---| Tgfb1 Tgfb1 ---- Tgfbr2 Smad3 ---> Translocated Smad Smad2 ---> Translocated Smad Smad4 ---> Translocated Smad Translocated Smad ---> Tgf-beta target genes Tgf-beta target genes ---> Smad7
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Genes in Pathway:

show annotations for term's descendants       view all columns
transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:2298922
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:6484113
G Atf3 activating transcription factor 3 JBrowse link 13 109,817,892 109,849,632 RGD:2302137
RGD:5143919
G Axin1 axin 1 RGD:6484113
G Bambi BMP and activin membrane-bound inhibitor JBrowse link 17 56,905,419 56,909,675 RGD:6484113
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:6484113
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6484113
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:1625706
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:2302137
RGD:5143919
G Ctgf connective tissue growth factor JBrowse link 1 21,851,657 21,854,773 RGD:6484113
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6484113
G Dact2 dishevelled-binding antagonist of beta-catenin 2 JBrowse link 1 56,159,435 56,169,443 RGD:6484113
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:6484113
G Dcn decorin JBrowse link 7 38,742,250 38,782,282 RGD:2298922
G Dynlrb1 dynein light chain roadblock-type 1 JBrowse link 3 150,761,329 150,782,493 RGD:6484113
G Eif2a eukaryotic translation initiation factor 2A JBrowse link 2 148,722,343 148,755,781 RGD:6484113
G Fkbp1a FK506 binding protein 1a JBrowse link 3 147,042,944 147,062,725 RGD:2298922
RGD:6484113
G Foxh1 forkhead box H1 JBrowse link 7 117,730,307 117,733,076 RGD:2302137
RGD:5143919
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:2302137
RGD:5143919
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:2302137
RGD:5143919
G Foxo4 forkhead box O4 JBrowse link X 71,155,284 71,162,158 RGD:2302137
RGD:5143919
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6484113
G Itch itchy E3 ubiquitin protein ligase JBrowse link 3 150,660,665 150,752,016 RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:6484113
G Nedd4l neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase JBrowse link 18 60,392,376 60,719,720 RGD:6484113
G Ocln occludin JBrowse link 2 30,527,327 30,577,218 RGD:6484113
G Pard6a par-6 family cell polarity regulator alpha JBrowse link 19 37,668,133 37,670,450 RGD:6484113
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6484113
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:6484113
G Ppp1ca protein phosphatase 1 catalytic subunit alpha JBrowse link 1 219,439,953 219,443,570 RGD:6484113
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A JBrowse link 1 101,511,899 101,515,043 RGD:6484113
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:6484113
G Ppp2cb protein phosphatase 2 catalytic subunit beta JBrowse link 16 62,273,276 62,294,767 RGD:6484113
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha JBrowse link 15 43,673,958 43,733,182 RGD:6484113
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6484113
G Rnf111 ring finger protein 111 JBrowse link 8 76,864,343 76,940,235 RGD:6484113
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6484113
G Runx1 runt-related transcription factor 1 JBrowse link 11 32,765,147 33,003,061 RGD:2302137
RGD:5143919
G Runx2 runt-related transcription factor 2 JBrowse link 9 18,564,743 18,773,092 RGD:2302137
RGD:5143919
G Runx3 runt-related transcription factor 3 JBrowse link 5 153,507,093 153,531,137 RGD:2302137
RGD:5143919
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:6484113
G Skil SKI-like proto-oncogene JBrowse link 2 115,862,932 115,891,304 RGD:6484113
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:1599906
RGD:2298922
RGD:2302517
RGD:6484113
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:1299323
RGD:1599906
RGD:1625706
RGD:2298922
RGD:6484113
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:1599906
RGD:2298922
RGD:6484113
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:2298922
RGD:6484113
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 12 11,433,815 11,526,465 RGD:2298922
RGD:6484113
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 JBrowse link 10 95,018,050 95,118,107 RGD:2298922
RGD:6484113
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6484113
G Sptbn1 spectrin, beta, non-erythrocytic 1 JBrowse link 14 114,517,839 114,700,199 RGD:6484113
G Strap serine/threonine kinase receptor associated protein JBrowse link 4 171,730,629 171,744,877 RGD:6484113
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:6484113
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:6484113
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2298921
RGD:6484113
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:2298921
RGD:6484113
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:2298922
RGD:6484113
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:2298922
RGD:2302517
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:2298921
RGD:2302517
RGD:6484113
G Tgfbr3 transforming growth factor beta receptor 3 JBrowse link 14 3,506,416 3,680,508 RGD:2298922
RGD:6484113
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 JBrowse link 5 33,608,489 33,696,487 RGD:6484113
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:6484113
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon JBrowse link 10 63,884,338 63,921,709 RGD:6484113
G Zfyve16 zinc finger FYVE-type containing 16 JBrowse link 2 22,060,879 22,105,822 RGD:6484113
G Zfyve9 zinc finger FYVE-type containing 9 JBrowse link 5 128,233,096 128,392,675 RGD:2298922
RGD:6484113
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:2306282
RGD:2308865
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:2306282
RGD:5490966
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:2306282
RGD:2308865
RGD:5490965
RGD:5490966
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:2308865
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2299005
RGD:2306282
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:2299005
RGD:2306282
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:2299005
RGD:2306282
RGD:2308865
RGD:5490965
RGD:5490966

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupTgf-beta target genestransforming growth factor, beta target genes

Pathway Gene Annotations

Disease Annotations Associated with Genes in the transforming growth factor-beta Smad dependent signaling pathway
Disease TermsGene Symbols
Aberrant Crypt FociCtnnb1
Abnormalities, Drug-InducedRhoa
Abnormalities, MultipleCrebbp , Ctnnb1 , Smad2 , Sptbn1
Abortion, SpontaneousTgfb1 , Tgfbr1
Acro-OsteolysisSmad4
Acromicric dysplasiaSmad2 , Tgfb1
Acute Kidney InjuryA2m , Ocln , Tgfb1
Acute Lung InjuryCav1 , Tgfb1
AdenocarcinomaCtgf , Ctnnb1 , Runx3 , Strap , Tgfb1
Adenocarcinoma of EsophagusSmad4
Adenocarcinoma of LungCrebbp , Ctnnb1 , Foxo3 , Rhoa , Smad4 , Sos1
ADENOCARCINOMA OF STOMACHCrebbp , Ctnnb1 , Rhoa , Smad4
Adenocarcinoma, Clear CellDaxx
Adenocarcinoma, ColonDaxx
Adenocarcinoma, ProstaticCtnnb1 , Smad4
AdenomaCtnnb1
Adenoma, Liver CellA2m , Ctnnb1
Adrenal Gland NeoplasmsCtnnb1
Adrenocortical CarcinomaCtnnb1 , Daxx
Aging, PrematureFoxo1
Alcohol-Induced DisordersFoxo4
Alpha-2-Macroglobulin DeficiencyA2m
Alzheimer DiseaseA2m , Crebbp , Ctnnb1 , Foxo3 , Runx1 , Shc1
Amaurosis FugaxPpp1r15a
Amphetamine-Related DisordersArrb2
Amyotrophic Lateral SclerosisPpp1r15a , Runx1
Amyotrophic Lateral Sclerosis 1Crebbp , Shc1 , Xiap
Anemia, AplasticTgfb1
Anemia, HemolyticA2m
Anemia, Sickle CellTgfb1
AnetodermaTgfb1
AneurysmSmad3 , Tgfbr2
Aneurysm, DissectingSmad3 , Tgfbr1 , Tgfbr2
Aortic AneurysmSmad3 , Tgfbr1 , Tgfbr2
Aortic Aneurysm, AbdominalCav1
Aortic Aneurysm, Familial Thoracic 1Tgfbr2
Aortic Aneurysm, Familial Thoracic 3Tgfbr2
Aortic Aneurysm, ThoracicSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
Aortic DiseasesSmad4
Aortic Valve InsufficiencyCtgf , Tgfb1 , Tgfb2
Arrhythmogenic Right Ventricular DysplasiaTgfb3
Arrhythmogenic Right Ventricular Dysplasia, Familial, 1Tgfb3
Arsenic PoisoningSkil
ArteriosclerosisTgfb1 , Tgfbr2
Arteriovenous FistulaArrb2
Arthritis, ExperimentalA2m , Arrb2 , Tgfbr2
Arthritis, JuvenileSmad3
Arthritis, PsoriaticRunx2
Arthritis, RheumatoidA2m , Ctgf , Foxo3 , Runx1 , Runx2
AsthmaDcn , Ppp2ca , Rhoa , Runx1 , Tgfb1
Asthma, OccupationalTgfb1
AtherosclerosisCav1
Atrial FibrillationCav1
AtrophyRps6kb1
Attention Deficit Disorder with HyperactivityCrebbp
Autoimmune Disease, Multisystem, with Facial DysmorphismItch
Autoimmune DiseasesRunx1 , Tgfb2
Behcet SyndromeTgfb1
BerylliosisTgfb1
Bile Duct NeoplasmsRunx3
bladder urothelial carcinomaCrebbp , Ctnnb1
Bone DiseasesCtgf , Tgfbr2
Bone Diseases, DevelopmentalTgfb2
Bone NeoplasmsTgfbr2
BrachydactylySmad4
Brain InjuriesRhoa
Brain IschemiaCav1 , Creb1 , Ppp1r15a , Tgfb1
Brain NeoplasmsCtnnb1
Breast NeoplasmsCav1 , Ctnnb1 , Dcn , Ocln , Pdpk1 , Rhoa , Runx3 , Smad2 , Smad4 , Tgfb1 , Wwp1 , Xiap
BurnsA2m , Ocln , Rps6kb1
CachexiaTgfb1
Cafe au lait Spots, MultipleSos1
CalcinosisCtnnb1 , Tgfb1
Camurati-Engelmann SyndromeTgfb1
CarcinomaRhoa , Tgfb1 , Tgfbr2
Carcinoma in SituCtnnb1 , Runx3
Carcinoma, Adenoid CysticCrebbp , Foxo3
Carcinoma, Ductal, BreastPml , Smad4
Carcinoma, EndometrioidCtnnb1 , Daxx
Carcinoma, HepatocellularA2m , Axin1 , Crebbp , Ctnnb1 , Dynlrb1 , Shc1 , Smad2 , Smad4 , Tgfb1 , Tgfbr2
Carcinoma, Islet CellDaxx
Carcinoma, Large CellStrap
Carcinoma, LobularCtnnb1
Carcinoma, Non-Small-Cell LungAtf3 , Foxo3
Carcinoma, Pancreatic DuctalTgfb1 , Tgfbr2
Carcinoma, Renal CellCav1 , Ctnnb1 , Smad2 , Smad4 , Xiap
Carcinoma, Squamous CellCav1 , Crebbp , Smurf2 , Tgfb1
Carcinoma, Squamous Cell of Head and NeckCrebbp , Ctnnb1 , Rhoa , Smad4
Carcinoma, Transitional CellCav1 , Crebbp , Ctnnb1 , Daxx , Smad4
CarcinosarcomaTgfb1
Cardiac FibrosisTgfb1
Cardiac Output, LowPpp1ca
CardiomegalyA2m , Cav1 , Rhoa , Rps6kb1 , Shc1 , Tgfb1
CardiomyopathiesAtf3 , Runx1
Cardiomyopathy, DilatedCreb1 , Nedd4l , Ppp1ca , Rps6kb1
Cardiomyopathy, HypertrophicCtnnb1 , Sos1 , Tgfb1 , Tgfb3
Cardiomyopathy, Hypertrophic, FamilialSos1
Cardiomyopathy, RestrictiveCtgf
Carotid Artery DiseasesTgfb1
Carotid Artery InjuriesCtgf , Foxo3
Caudal Duplication AnomalyAxin1
Cecal NeoplasmsCtnnb1
Celiac DiseaseRunx3
Cell Transformation, NeoplasticOcln , Tgfb1
Ceroid Lipofuscinosis, Neuronal 1, InfantileRps6kb1
Cervical Intraepithelial NeoplasiaXiap
CholangiocarcinomaRunx3 , Smad4 , Tgfb1 , Tgfbr2
CholangitisTgfb2
ChorioamnionitisTgfb1
Chromosomal InstabilityPpp2r2a
CicatrixSmad4
Cleft PalateNedd4l , Tgfb1 , Tgfb2 , Tgfb3
Cleidocranial DysplasiaRunx2
Cleidocranial Dysplasia, Forme Fruste, Dental Anomalies OnlyRunx2
Cleidocranial Dysplasia, Forme Fruste, with BrachydactylyRunx2
Cocaine-Related DisordersCamk2a , Creb1
Cognition DisordersSmad4
Colitis, ExperimentalSmad4
colon cancerCtnnb1
Colonic NeoplasmsA2m , Ctnnb1 , Runx3 , Tgfbr2
colorectal cancerCtnnb1 , Rhoa
Colorectal Cancer, Hereditary Nonpolyposis, Type 6Tgfbr2
Colorectal NeoplasmsAxin1 , Crebbp , Ctnnb1 , Rhoa , Runx3 , Smad4 , Smad7 , Strap , Tgfb1 , Tgfbr1
Colorectal Neoplasms, Hereditary NonpolyposisSmad2 , Smad3 , Smad4 , Tgfbr1 , Tgfbr2
Congenital Heart Defects, Multiple Types, 2Tab2
Conjunctivitis, AllergicTgfb1
Copper-Overload CirrhosisSmad2 , Tgfb1
Corneal Dystrophy, Congenital StromalDcn
Coronary Artery DiseaseTgfb1
Cranioectodermal dysplasiaTgfb3
Craniofacial AbnormalitiesCtnnb1 , Runx2 , Smad2 , Smad3 , Smad4 , Tgfb2 , Tgfbr2
CraniopharyngiomaCtnnb1
Crohn DiseaseOcln , Smad3
CyanosisTgfb2
CyclopiaFoxh1
Cystadenoma, MucinousDaxx
Cystadenoma, SerousDaxx
Cystic FibrosisTgfb1
DeafnessSmad4
Demyelinating DiseasesPpp1r15a
Dermal FibrosisCav1
Dermatitis, AtopicTgfb1
Dermatitis, ContactCtgf
Desmoid Disease, HereditaryCtnnb1
Developmental DisabilitiesOcln
Diabetes MellitusCav1
Diabetes Mellitus, ExperimentalAtf3 , Cav1 , Ctgf , Dcn , Foxo3 , Rhoa , Tgfb1 , Tgfb2
Diabetes Mellitus, Insulin-Dependent, 5Tab2
Diabetes Mellitus, Type 1Foxo1 , Tgfb1
Diabetes Mellitus, Type 2Atf3 , Ctgf , Dcn , Foxo1 , Ppp2ca , Smad4 , Tgfb1 , Tgfbr2
Diabetes, GestationalDcn
Diabetic CardiomyopathiesA2m
Diabetic NephropathiesCreb1 , Ctgf , Dcn , Tgfb1 , Tgfbr2
Diabetic NeuropathiesCav1 , Tgfb1 , Tgfb2 , Tgfb3
Diabetic RetinopathyCtgf , Ocln
Diaphyseal Dysplasia 1, ProgressiveTgfb1
Digestive System NeoplasmsRunx3
Dilatation, PathologicTgfb1
DiseaseCtnnb1
Disease Models, AnimalRhoa
Drug-Induced Liver InjuryCtnnb1
Dry Eye SyndromesTgfb1
Duodenal UlcerTgfb1
DwarfismCtgf
Ehlers-Danlos SyndromeTgfb1
EmphysemaPpp1r15a , Ppp2r2a
Encephalomyelitis, Autoimmune, ExperimentalA2m , Rhoa , Tgfb1 , Tgfb2
Endodermal Sinus TumorCtnnb1
Endometrial NeoplasmsCtnnb1 , Dcn , Runx3 , Smad2 , Smad3 , Smad4 , Smad7 , Tgfbr3
EndometriosisNedd4l , Runx1 , Tgfb2
Endomyocardial FibrosisCtgf , Tgfb1
Eosinophilic EsophagitisTgfb1
Epilepsy, Temporal LobeFoxo3
Erectile DysfunctionTgfb1
Esophageal NeoplasmsCtnnb1 , Rhoa , Runx3 , Smad4 , Tgfbr2 , Xiap
Esophageal Squamous Cell CarcinomaCrebbp , Ctnnb1 , Fkbp1a
Exfoliation SyndromeCav1
Exudative vitreoretinopathy 1Ctnnb1
Eye AbnormalitiesTgfb2 , Tgfbr2
Familial Primary Pulmonary HypertensionSmad4
FatigueTgfbr2
Fatty LiverCreb1 , Shc1
Femur Head NecrosisA2m
Fetal Alcohol SyndromeRhoa
FeverA2m , Ctgf
Fibromatosis, AggressiveCtgf
Fibromatosis, GingivalSos1
Fibromatosis, Gingival, 1Sos1
FibrosisCtgf , Dcn , Rhoa , Tgfb1
Forney Robinson Pascoe SyndromeMap3k7
Fractures, BoneRunx1 , Runx2 , Sptbn1 , Tgfbr2
Frontometaphyseal Dysplasia 2Map3k7
Gallbladder NeoplasmsRunx3 , Tgfb1
Gastrointestinal NeoplasmsSmad4
Genetic Diseases, InbornCav1 , Crebbp , Ctnnb1 , Smad2
Genital Diseases, FemaleSmad2
GlaucomaCrebbp , Tgfb2
Glaucoma, Open-AngleCav1
Glaucoma, Primary Open AngleCav1
GlioblastomaCrebbp , Pml , Runx1 , Runx3
GliomaCav1 , Dcn
Glomerulonephritis, IGATgfb1
Glomerulonephritis, MembranoproliferativeCtgf , Tgfbr2
Glomerulonephritis, MembranousA2m , Rhoa
Glomerulosclerosis, Focal SegmentalCtgf , Tgfb1
Granulosa Cell TumorCtnnb1
Growth Mental Deficiency Syndrome of MyhreSmad4
Hearing Loss, Cisplatin-InducedCamk2a
Heart Defects, CongenitalFkbp1a , Tgfb2
Heart DiseasesA2m , Ppp2ca , Tgfb1
Heart FailureCtgf , Foxo1 , Pdpk1 , Ppp1ca , Ppp2ca
Heart Septal Defects, VentricularTgfb3
Heavy Metal ToxicityDaxx
HemangiosarcomaCtnnb1
Hemophilia ATgfb1
HemorrhageCav1
Hepatic Veno-Occlusive DiseaseOcln
Hepatitis B, ChronicCtgf
Hepatitis, AutoimmuneTgfb1
Hepatitis, ChronicShc1 , Smad2 , Tgfb1
HepatoblastomaCtnnb1
Hepatoblastoma Caused By Somatic MutationCtnnb1
Hepatolenticular DegenerationA2m , Camk2a
HepatomegalyCamk2a
Hernia, DiaphragmaticTgfb1
Hernia, InguinalTgfbr2
Hernias, Diaphragmatic, CongenitalCtgf , Rhoa
Hirschsprung Disease 1Crebbp
Histiocytoma, Angiomatoid FibrousCreb1
HoloprosencephalyCreb1 , Foxh1
Holt-Oram SyndromeTgfb2
Huntington DiseaseCreb1
HyperalgesiaCamk2a
HyperglycemiaShc1
HyperinsulinismRps6kb1
HyperlipidemiasShc1 , Tgfb1
HyperoxaluriaRunx2
HyperoxiaTgfb1
HyperplasiaCav1 , Tgfb1 , Tgfbr2
HypersensitivityTgfb1
HypertensionCav1 , Ctgf , Nedd4l , Rhoa , Rps6kb1 , Tgfb1 , Tgfb3
Hypertension, PulmonaryCav1 , Ctgf , Rhoa , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
Hypertensive NephropathyShc1
Hypertrophy, Left VentricularCtgf , Foxo3 , Rhoa , Rps6kb1 , Shc1
Hypertrophy, Right VentricularTgfb1
HypoalbuminemiaA2m
Hypoglossal Nerve InjuriesSmad2 , Smad3 , Smad4 , Smad7
HypoglycemiaCreb1
HypoproteinemiaRps6kb1
HypospadiasAtf3
HypothyroidismCav1
Hypoxia-Ischemia, BrainDaxx , Foxo3
Immunoblastic LymphadenopathyRhoa
Impotence, VasculogenicTgfbr2
Infarction, Middle Cerebral ArteryAtf3 , Runx1
InfectionCtnnb1
Infertility, FemaleCtgf
InflammationA2m , Camk2a , Tgfb1
Influenza, HumanAtf3
Insulin ResistanceFoxo1 , Shc1
InsulinomaTgfb1
Intervertebral Disc DegenerationTgfb1
Intestinal NeoplasmsCtnnb1
Intestinal PolyposisSmad4
Intestinal Reperfusion InjuryPpp1r15a
Intimal HyperplasiaFoxo3
Ischemic Attack, TransientCav1 , Creb1 , Daxx , Ppp1r15a
Juvenile Polyposis SyndromeSmad4
Juvenile Polyposis with Hereditary Hemorrhagic TelangiectasiaSmad4
Keratoacanthoma FamilialTgfbr1
KeratoconusFoxo1
Keratosis, ActinicTgfb1
Kidney DiseasesTgfb1 , Tgfbr1 , Tgfbr2
Kidney Failure, ChronicTgfb1
Kidney Reperfusion InjuryDaxx
Laryngotracheal Stenosis, Progressive, with Short Stature and ArthropathySmad4
LeiomyomaCav1 , Smad3 , Tgfbr1
LeukemiaDaxx
Leukemia, ExperimentalRunx1
Leukemia, LymphoidRunx1
Leukemia, Megakaryoblastic, AcuteRunx1
Leukemia, Myeloid, AcuteCrebbp , Foxo1 , Runx1 , Runx3
Leukemia, Myelomonocytic, JuvenileRunx1
Leukemia, Promyelocytic, AcutePml
Limb Deformities, CongenitalTgfb2
Lipodystrophy with Congenital Cataracts and NeurodegenerationCav1
Lipodystrophy, Congenital Generalized, Type 3Cav1
Lipodystrophy, Familial PartialCav1
Liver CirrhosisA2m , Ctgf , Ctnnb1 , Smad3 , Tgfb1
Liver Cirrhosis, AlcoholicSmad3 , Tgfb1
Liver Cirrhosis, BiliaryCtgf , Rps6kb1
Liver Cirrhosis, ExperimentalA2m , Arrb2 , Atf3 , Cav1 , Ctgf , Fkbp1a , Rhoa , Skil , Smad2 , Smad4 , Tgfb1 , Tgfb3 , Tgfbr1 , Tgfbr2 , Zfyve16
Liver Diseases, AlcoholicCav1
Liver Diseases, ParasiticSmad4
Liver NeoplasmsAtf3 , Axin1 , Crebbp , Ctnnb1 , Dact2
Liver Neoplasms, ExperimentalArrb2 , Ctnnb1 , Pml , Ppp2ca
Loeys-Dietz SyndromeSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
LOEYS-DIETZ SYNDROME 2Tgfbr2
Loeys-Dietz Syndrome 3Smad3
Loeys-Dietz Syndrome 4Tgfb2 , Tgfb3
Loeys-Dietz Syndrome 5Tgfb3
Loeys-Dietz Syndrome, Type 1bTgfbr2
Low Tension GlaucomaCav1
Lung DiseasesA2m , Ctgf , Tgfb1
Lung Diseases, InterstitialTgfb1
Lung Diseases, ObstructiveA2m
Lung NeoplasmsA2m , Ctgf , Ctnnb1 , Runx3 , Strap , Tgfb1 , Tgfbr2
Lymphatic MetastasisCav1 , Ctnnb1 , Rhoa , Smad4
Lymphoma, FollicularCrebbp
Lymphoma, Large B-Cell, DiffusePdpk1 , Rps6kb1
Lymphoma, Mantle-CellCtnnb1
Lymphoma, Non-HodgkinRhoa
Lymphoma, T-CellRhoa , Runx1
Lymphoma, T-Cell, CutaneousRhoa
Lymphoma, T-Cell, PeripheralRhoa
Lymphoproliferative DisordersXiap
Lymphoproliferative Syndrome, X-Linked, 2Xiap
Mammary Neoplasms, ExperimentalCav1 , Ctnnb1 , Tgfb1 , Tgfbr1 , Tgfbr2 , Xiap
Marfan SyndromeTgfbr2
MedulloblastomaCrebbp , Ctnnb1
MelanomaCav1 , Crebbp , Ctnnb1 , Ppp2ca
Memory DisordersCreb1
Mental Retardation, Autosomal Dominant 19Ctnnb1
Mesothelioma, MalignantCtnnb1 , Tgfb2
Metabolic Syndrome XTgfb1
Metaphyseal Dysplasia with Maxillary Hypoplasia and BrachydactylyRunx2
Metaphyseal Dysplasia with Maxillary Hypoplasia with or without BrachydactylyRunx2
Micronuclei, Chromosome-DefectivePpp2r2a
Microphthalmia, Cataracts, and Iris AbnormalitiesSmad4
Microsatellite InstabilityTgfbr2
Migraine DisordersTgfbr2
Morphine DependenceCreb1
Multiple MyelomaRunx1 , Tgfb1
Multiple SclerosisCav1 , Rhoa
Muscular AtrophyCtnnb1 , Rps6kb1
Muscular DiseasesSmad4 , Tgfb1
Muscular Dystrophy, DuchenneTgfb1
Muscular Dystrophy, FacioscapulohumeralDcn
Musculoskeletal AbnormalitiesTgfb2
Myelodysplastic SyndromesRunx1
Myeloproliferative DisordersRunx1
Myocardial InfarctionCreb1 , Ctgf , Dcn , Rps6kb1 , Smad2 , Smad4 , Tgfb1 , Tgfb2 , Tgfbr1 , Tgfbr2
Myocardial IschemiaDcn , Eif2a , Ppp2ca
Myocardial Reperfusion InjuryRhoa , Smad3 , Smad4 , Tgfb1 , Xiap
Myocarditis, Autoimmune, ExperimentalCav1
Nasal PolypsTgfb1
NecrosisCtgf
NeointimaFoxo4
Neoplasm InvasivenessCtnnb1 , Rhoa , Tgfb1
Neoplasm MetastasisCav1 , Ctnnb1 , Daxx , Dcn , Rhoa , Tgfb1 , Tgfbr1 , Tgfbr2 , Ywhae
NeoplasmsCtnnb1 , Ocln
Neoplasms, Germ Cell and EmbryonalRhoa
Neoplasms, Second PrimaryPml
Neoplasms, Squamous CellStrap
Neoplastic Syndromes, HereditarySmad4
NephritisSmad7
Nephritis, InterstitialDcn
Nephrogenic Fibrosing DermopathyCav1
Nephrolithiasis, Calcium OxalateTgfb1
Nephrotic SyndromeA2m , Tgfb1
Nerve DegenerationCtnnb1
Nervous System DiseasesAtf3
NeuralgiaTgfb1
Neuritis, Autoimmune, ExperimentalCav1 , Rhoa
Neurodevelopmental DisordersCtnnb1
Neuroendocrine TumorsDaxx
Neuroma, AcousticCav1
No-Reflow PhenomenonCtnnb1
Non-alcoholic Fatty Liver DiseaseTgfb1
Nonproliferative Diabetic RetinopathyA2m
Noonan like syndromeSos1
Noonan SyndromeSos1
Noonan Syndrome 4Sos1
ObesityCav1 , Dcn , Foxo3 , Rhoa , Rps6kb1 , Tgfb1
Occupational DiseasesTgfb1
Odontogenic CystsSmad4
Optic Nerve InjuriesRhoa
Oral Submucous FibrosisTgfb1
Osseous Heteroplasia, ProgressiveCtnnb1
Ossification, HeterotopicRunx2 , Smad4
Osteitis DeformansPml
OsteoarthritisCav1 , Runx2 , Smad3
Osteoarthritis, KneeCtnnb1
OsteochondrodysplasiasTgfb1 , Tgfb2 , Tgfbr1
OsteoporosisTgfb1
Osteoporosis, PostmenopausalTgfb1
OsteosarcomaRunx2
Ovarian Epithelial CancerDaxx
Ovarian NeoplasmsAtf3 , Cav1 , Ctgf , Ctnnb1 , Rhoa , Runx3 , Smad2 , Smad4 , Smad7 , Xiap
Pancreatic AdenocarcinomaCtnnb1 , Smad4
Pancreatic CarcinomaSmad4
pancreatic carcinoma Smad4
Pancreatic Islet Cell TumorsDaxx
Pancreatic NeoplasmsCtnnb1 , Daxx , Runx3 , Smad3 , Smad4 , Smurf1 , Tgfb1 , Tgfbr2
PapillomaTgfb1
ParaplegiaFoxo4
Paraquat LungSkil , Smad7 , Tgfb1
Parkinson DiseaseA2m , Ctgf , Ppp2ca
Parkinsonian DisordersFkbp1a
Penile IndurationTgfb1
Peripheral Nervous System DiseasesAtf3
Peritoneal FibrosisTgfb1
Peritoneal NeoplasmsCtnnb1
PeritonitisA2m
Periventricular Nodular HeterotopiaNedd4l
PERIVENTRICULAR NODULAR HETEROTOPIA 7Nedd4l
PERIVENTRICULAR NODULAR HETEROTOPIA WITH SYNDACTYLY, CLEFT PALATE AND DEVELOPMENTAL DELAYNedd4l
Phyllodes TumorCtnnb1
Pick Disease of the BrainCreb1
PilomatrixomaCtnnb1
Platelet Disorder, Familial, with Associated Myeloid MalignancyRunx1
Pleomorphic Xanthoastrocytoma Cav1 , Smurf1
Pleural DiseasesTgfb1
PneumoniaTgfb1
Polycystic Kidney, Autosomal DominantRps6kb1
Polycystic Ovary SyndromeRunx3 , Tab1
Precancerous ConditionsSmad3 , Smad4
Precursor B-Cell Lymphoblastic Leukemia-LymphomaCtgf , Runx1
Precursor Cell Lymphoblastic Leukemia-LymphomaCrebbp , Runx1
Precursor T-Cell Lymphoblastic Leukemia-LymphomaRunx1
Prenatal Exposure Delayed EffectsCtgf
Primary MyelofibrosisTgfb1
Prostatic Intraepithelial NeoplasiaSmad4
Prostatic NeoplasmsAtf3 , Cav1 , Crebbp , Ctnnb1 , Daxx , Foxo1 , Foxo3 , Map3k7 , Ppp2ca , Runx1 , Skil , Smad3 , Smad4 , Tgfb1 , Tgfbr2 , Tgfbr3 , Wwp1 , Xiap
ProstatitisSmad4
ProteinuriaRhoa , Tgfb1
PSEUDO-TORCH SYNDROME 1Ocln
PsoriasisCav1 , Runx3 , Tgfb1
Pulmonary Disease, Chronic ObstructiveCtgf , Foxo3 , Smad4 , Tgfb1
Pulmonary EmbolismCtgf
Pulmonary EmphysemaTgfb1
Pulmonary FibrosisCav1 , Ctgf , Skil , Smad4 , Smad7 , Tgfb1 , Tgfbr2
Pulmonary Hypertension, Primary, 3Cav1
Purpura, Thrombocytopenic, IdiopathicTgfb1
Radiation InjuriesTgfbr2
Radiation Injuries, ExperimentalCtgf
Radiation PneumonitisTgfb1
RASopathiesSos1
Reperfusion InjuryCav1 , Eif2a , Tgfbr2
Respiratory System AbnormalitiesTgfb2 , Tgfb3
Retinal DiseasesOcln
Rhabdomyosarcoma, AlveolarFoxo1
RhinitisTgfb1
Rubinstein-Taybi SyndromeCrebbp
SarcoidosisTgfb1
Sarcoidosis, PulmonaryTgfb1
SarcopeniaCav1 , Foxo4
SchizophreniaCreb1 , Pml
Sciatic NeuropathyCav1 , Creb1 , Runx1
Scleroderma, LimitedCav1
Scleroderma, LocalizedTgfb1
Scleroderma, SystemicCav1 , Ctgf
ScoliosisCrebbp
SeminomaSmad4
SepsisA2m , Tgfb1
Sezary SyndromeCrebbp
Shock, SepticA2m
Sjogren's SyndromeTgfb1
Skin DiseasesSkil
Skin NeoplasmsCtnnb1 , Tgfb1 , Tgfbr1
Small Cell Lung CarcinomaCrebbp
Smith-Magenis SyndromeGrb2 , Rps6kb1 , Smurf2
Spina Bifida CysticaRunx1
Spinal Cord InjuriesCav1 , Foxo3 , Ppp1r15a , Smurf1 , Tgfb1 , Tgfb2
SplenomegalyOcln
SpondylarthritisRunx2
Spondylitis, AnkylosingRunx3
Squamous Cell Carcinoma of the LungCrebbp
Status EpilepticusFoxo3
Stevens-Johnson SyndromeCav1 , Ctnnb1 , Pml
Stomach NeoplasmsCav1 , Ctnnb1 , Rhoa , Runx3 , Smad4 , Sptbn1
Stomach UlcerFoxo4
Stomatognathic System AbnormalitiesRunx2
StrokeCtnnb1 , Nedd4l , Ppp1r15a , Tgfb1
Substance Withdrawal SyndromeCreb1
SyndactylyNedd4l
Telangiectasia, Hereditary HemorrhagicSmad4
Telangiectasia, Hereditary Hemorrhagic, Type 1Tgfb1
TendinopathyCtgf
TeratomaCtnnb1
Tetralogy of FallotFoxh1
Therapy-related Acute Myeloid LeukemiaRunx1
Thrombocythemia, EssentialTgfb1
ThrombocytopeniaRunx1 , Tgfb1
Thumb DeformityCrebbp
Tooth AbnormalitiesRunx2
Tracheal StenosisTgfb1
Transient Myeloproliferative Disorder of Down SyndromeRunx1
TrypanosomiasisA2m
Tumor Predisposition SyndromeSmad4
UremiaRunx2 , Tgfb1 , Tgfbr1
Ureteral ObstructionCtgf , Skil , Tgfb1 , Tgfb2
Urethral ObstructionTgfb1
Urinary Bladder NeoplasmsCav1 , Crebbp , Ctnnb1 , Rhoa , Runx3 , Smad2 , Smad4 , Tgfbr1
Urogenital AbnormalitiesTgfb2
Urologic NeoplasmsRhoa
UrticariaTgfb1
Uterine Cervical NeoplasmsCrebbp , Ctnnb1 , Smad2 , Smad4 , Xiap
Uterine NeoplasmsCtnnb1 , Smad3 , Sos1
UveitisTgfb1
Vascular CalcificationCtnnb1
Ventricular Premature ComplexesTgfb3
Ventricular RemodelingSmad2 , Smad3 , Tgfb1
VitiligoTgfb1
Wallerian DegenerationTgfb1 , Tgfb2
Weight GainCav1 , Sptbn1
Wilms TumorCtnnb1
Wounds and InjuriesDcn , Tgfb1 , Tgfb2 , Tgfb3
Pathway Annotations Associated with Genes in the transforming growth factor-beta Smad dependent signaling pathway
Pathway TermsGene Symbols
activin signaling pathwayFkbp1a , Smad2 , Smad3
acute myeloid leukemia pathwayGrb2 , Pml , Rps6kb1 , Runx1 , Sos1
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayPpp1ca , Ppp2ca
adenosine signaling pathwayCreb1 , Pard6a , Pdpk1
aldosterone signaling pathwayCrebbp , Daxx , Nedd4l , Pdpk1
altered transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
altered Wnt signaling, canonical pathwayAxin1 , Ctnnb1
Alzheimer disease pathwayA2m
amyotrophic lateral sclerosis disease pathwayDaxx
androgen signaling pathwayCrebbp
angiotensin II signaling pathwayPdpk1
angiotensin II signaling pathway via AT1 receptorArrb2
antigen processing and presentation pathwayCreb1
apoptotic cell death pathwayXiap
arrhythmogenic right ventricular cardiomyopathy pathwayCtnnb1
ataxia telangiectasia-mutated (ATM) signaling pathwayPpp2ca
B cell receptor signaling pathwayGrb2 , Sos1
basal cell carcinoma pathwayAxin1 , Ctnnb1
Bone morphogenetic proteins signaling pathwayBambi , Map3k7 , Ppp1ca , Ppp1r15a , Smad4 , Smad7 , Smurf1 , Smurf2 , Tab1 , Tab2 , Xiap , Zfyve16
brain-derived neurotrophic factor signaling pathwayGrb2 , Shc1
c-Jun N-terminal kinases MAPK signaling pathwayMap3k7
calcium signaling pathway via the calcium-sensing receptorArrb2 , Rhoa
calcium/calcium-mediated signaling pathwayCamk2a
calcium/calmodulin dependent kinase 2 signaling pathwayCamk2a , Ppp2ca
cell cycle pathway, mitoticCrebbp , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Ywhae
ceramide signaling pathwayEif2a , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
chemokine mediated signaling pathwayArrb2 , Foxo3 , Grb2 , Rhoa , Shc1 , Sos1
chronic myeloid leukemia pathwayGrb2 , Runx1 , Shc1 , Smad3 , Smad4 , Sos1 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
coagulation cascade pathwayA2m
colorectal cancer pathwayAxin1 , Ctnnb1 , Rhoa , Smad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
complement system pathwayA2m
corticotropin-releasing hormone signaling pathwayArrb2
cortisol signaling pathwayCrebbp
cytokine mediated signaling pathwayTgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
dilated cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
dopamine signaling pathwayPpp1ca , Ppp2ca , Ppp2cb
dopamine signaling pathway via D1 family of receptorsArrb2
dopamine signaling pathway via D2 family of receptorsArrb2
E-cadherin signaling pathwayCtnnb1 , Rhoa
eicosanoid signaling pathwayArrb2 , Rhoa
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwayArrb2 , Cav1 , Itch , Nedd4l , Pard6a , Pml , Rhoa , Smad2 , Smad3 , Smad7 , Smurf2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Wwp1 , Zfyve16 , Zfyve9
endometrial cancer pathwayAxin1 , Ctnnb1 , Foxo3 , Grb2 , Pdpk1 , Sos1
endoplasmic reticulum stress - the unfolded protein response pathwayEif2a
Endoplasmic Reticulum-associated degradation pathwayPpp1r15a
endothelin signaling pathwayRhoa
Entamoeba histolyca infection pathwayTgfb1 , Tgfb2 , Tgfb3
ephrin - ephrin receptor bidirectional signaling axisGrb2 , Map3k7 , Rhoa
epidermal growth factor/neuregulin signaling pathwayCamk2a , Grb2 , Rps6kb1 , Shc1 , Sos1
epinephrine signaling pathway via adrenergic receptor betaArrb2
erythropoietin signaling pathwayGrb2 , Shc1 , Sos1
estrogen signaling pathwayCrebbp
FasL mediated signaling pathwayPdpk1
Fc epsilon receptor mediated signaling pathwayGrb2 , Sos1
Fc gamma receptor mediated signaling pathwayRps6kb1
fibroblast growth factor signaling pathwayCamk2a , Grb2 , Pdpk1 , Runx2 , Shc1 , Sos1
follicle-stimulating hormone signaling pathwayCreb1 , Ppp1ca
forkhead class A signaling pathwayCreb1 , Crebbp
glioma pathwayCamk2a , Grb2 , Shc1 , Sos1
glycogen biosynthetic pathwayPpp1ca
glycogen degradation pathwayPpp1ca
glypican signaling pathwaySmad2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr2
gonadotropin-releasing hormone signaling pathwayCamk2a , Grb2 , Sos1
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Shc1 , Sos1
Hedgehog signaling pathwayArrb2 , Crebbp , Tgfb2
hepatitis C virus infection pathwayGrb2 , Ocln , Ppp2ca , Ppp2cb , Ppp2r2a , Sos1
histamine signaling pathway, immunologicalCreb1 , Ppp1ca
histone modification pathwayCrebbp , Daxx
Huntington disease pathwayCreb1 , Crebbp
hypertrophic cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
hypoxia inducible factor pathwayCreb1 , Crebbp , Smad3 , Smad4
immune response pathwayA2m
inflammatory response pathwayA2m
influenza A virus infection pathwayCrebbp , Pml
insulin responsive facilitative sugar transporter mediated glucose transport pathwayYwhae
insulin signaling pathwayCav1 , Foxo1 , Foxo3 , Grb2 , Pard6a , Pdpk1 , Ppp1ca , Rps6kb1 , Shc1 , Sos1
insulin-like growth factor signaling pathwayGrb2 , Pdpk1 , Rps6kb1 , Shc1 , Sos1 , Ywhae
interleukin-1 signaling pathwayMap3k7 , Tab1 , Tab2
interleukin-2 signaling pathwayGrb2 , Rhoa , Shc1 , Sos1
interleukin-27 signaling pathwayTgfb1
interleukin-3 signaling pathwayGrb2 , Shc1
interleukin-4 signaling pathwayGrb2 , Rps6kb1 , Shc1
interleukin-5 signaling pathwayGrb2
interleukin-6 signaling pathwayA2m , Foxo1 , Grb2 , Sos1
intrinsic apoptotic pathwayXiap
Jak-Stat signaling pathwayCrebbp , Grb2 , Sos1
kallikrein-kinin cascade pathwayA2m
kinin signaling pathwayArrb2
Leishmania infection pathwayMap3k7 , Tgfb1 , Tgfb2 , Tgfb3
long term depressionPpp2ca , Ppp2cb
long term potentiationCamk2a , Crebbp , Ppp1ca
luteinizing hormone signaling pathwayCreb1 , Ppp1ca
measles infection pathwayMap3k7
mitochondria transport pathwayDynlrb1
mitogen activated protein kinase signaling pathwayArrb2 , Daxx , Grb2 , Map3k7 , Shc1 , Sos1 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
mRNA decay pathwayPpp2ca , Ppp2cb , Ppp2r2a
mTOR signaling pathwayFkbp1a , Pdpk1 , Pml , Rhoa , Rps6kb1 , Ywhae
Mycobacterium tuberculosis infection pathwayCamk2a , Creb1 , Crebbp , Rhoa , Tgfb1 , Tgfb2 , Tgfb3
myocarditis pathwayCav1
N-cadherin signaling pathwayAxin1 , Ctnnb1 , Rhoa
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayCamk2a , Foxo3 , Grb2 , Rhoa , Shc1 , Sos1 , Ywhae
NOD-like receptor signaling pathwayMap3k7 , Xiap
non-small cell lung cancer pathwayFoxo3 , Grb2 , Pdpk1 , Sos1
Notch signaling pathwayCrebbp , Itch
nuclear factor kappa B signaling pathwayArrb2 , Map3k7 , Tab1 , Tab2
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp
p38 MAPK signaling pathwayMap3k7 , Tab1 , Tab2
p53 signaling pathwayCrebbp , Daxx , Ppp2ca
pancreatic cancer pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
parathyroid hormone signaling pathwayArrb2
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Pdpk1 , Rhoa
phosphatidylinositol 3-kinase-Akt signaling pathwayFoxo1 , Foxo3 , Foxo4 , Pdpk1 , Ppp2ca , Ppp2cb , Ppp2r2a , Ywhae
Plasmodium infection pathwayTgfb1 , Tgfb2 , Tgfb3
platelet-derived growth factor signaling pathwayCav1 , Grb2 , Ppp2ca , Rhoa , Shc1 , Sos1 , Ywhae
prostate cancer pathwayCreb1 , Crebbp , Ctnnb1 , Foxo1 , Grb2 , Pdpk1 , Sos1
protein kinase C (PKC) signaling pathwayPard6a , Pdpk1
Ras family mediated signaling pathwaySos1
renal cell cancer pathwayCrebbp , Grb2 , Sos1 , Tgfb1 , Tgfb2 , Tgfb3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMap3k7
reverse cholesterol transport pathwayCav1
rheumatoid arthritis disease pathwayTgfb1 , Tgfb2 , Tgfb3
Rho/Rac/Cdc42 mediated signaling pathwayRhoa
RNA polymerase I transcription pathwayCrebbp
RNA transport pathwayStrap
scatter factor/hepatocyte growth factor signaling pathwayGrb2 , Shc1
serotonin signaling pathway via receptors engaging G alphas protein familyCreb1 , Ppp1ca
small cell lung cancer pathwayXiap
sphingosine 1-phosphate signaling pathwayRhoa
syndecan signaling pathwayRhoa , Tgfb1
T cell receptor signaling pathwayGrb2 , Map3k7 , Rhoa , Sos1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayShc1
thyroid cancer pathwayCtnnb1
Toll-like receptor signaling pathwayMap3k7 , Tab1 , Tab2
Toxoplasma gondii infection pathwayMap3k7 , Tgfb1 , Tgfb2 , Tgfb3 , Xiap
transforming growth factor-beta Smad dependent signaling pathwayA2m , Arrb2 , Atf3 , Axin1 , Bambi , Camk2a , Cav1 , Creb1 , Crebbp , Ctgf , Ctnnb1 , Dact2 , Daxx , Dcn , Dynlrb1 , Eif2a , Fkbp1a , Foxh1 , Foxo1 , Foxo3 , Foxo4 , Grb2 , Itch , Map3k7 , Nedd4l , Ocln , Pard6a , Pdpk1 , Pml , Ppp1ca , Ppp1r15a , Ppp2ca , Ppp2cb , Ppp2r2a , Rhoa , Rnf111 , Rps6kb1 , Runx1 , Runx2 , Runx3 , Shc1 , Skil , Smad2 , Smad3 , Smad4 , Smad7 , Smurf1 , Smurf2 , Sos1 , Sptbn1 , Strap , Tab1 , Tab2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tgfbr3 , Wwp1 , Xiap , Ywhae , Zfyve16 , Zfyve9
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Dcn , Ppp2ca , Ppp2cb , Rhoa , Rps6kb1 , Smad2 , Smad3 , Smad4 , Smad7 , Smurf2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Zfyve16 , Zfyve9
Trypanosoma cruzi infection pathwayPpp2ca , Ppp2cb , Ppp2r2a , Smad2 , Smad3 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
tumor necrosis factor mediated signaling pathwayCav1 , Itch , Map3k7 , Tab1 , Tab2
type II interferon signaling pathwayCamk2a , Crebbp , Smad7
ubiquitin/proteasome degradation pathwayItch , Nedd4l , Pml , Smurf2 , Wwp1 , Xiap
vascular endothelial growth factor signaling pathwayCav1 , Ctnnb1 , Grb2 , Pdpk1 , Rhoa
vasopressin signaling pathway via receptor type 2Creb1
visual phototransduction pathwayArrb2
Wnt signaling pathwayAxin1 , Camk2a , Crebbp , Ctnnb1 , Map3k7 , Ppp2ca , Ppp2cb , Rhoa , Smad2 , Smad3 , Smad4
Wnt signaling, canonical pathwayAxin1 , Cav1 , Crebbp , Ctnnb1
Wnt signaling, non-canonical pathwayArrb2 , Camk2a , Map3k7 , Rhoa , Tab1 , Tab2
Wnt signaling, the planar cell polarity pathwayRhoa
Phenotype Annotations Associated with Genes in the transforming growth factor-beta Smad dependent signaling pathway
Phenotype TermsGene Symbols
cardiac hypertrophyA2m , Crebbp
liver fibrosisSmad3

References Associated with the transforming growth factor-beta Smad dependent signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: