REELIN SIGNALING PATHWAY (PW:0000388)

View Ontology Report

Description

The Reelin signaling pathway controls neuronal migration and positioning in central nervous system (CNS) development, as well as synaptic plasticity and memory, operating through different receptors, probably depending on context. Defects in the Reelin gene lead to the reeler phenotype in mice, exhibiting neural positioning defects, and to lissencephaly in humans, with malformation of the cerebrum and cerebellum. Reelin signaling is also thought to be involved in Alzheimer's disease, autism and

Pathway Diagram:

Ariadne Genomics Inc. Src-related kinases --+> Grin2b Src-related kinases --+> Grin2a Src-related kinases Itga3 ---> integrin mediated signaling pathway P-tyrosine PAFAH1B3 PAFAH1B1 Dab1 ---- Vldlr Ca2+ ---> Gria1 phosphatidylinositol 3-kinase-Akt signaling pathway Grin2b ---- Vldlr Grin2a ---- Lrp8 Grin2a ---- Vldlr Grin2b ---- Lrp8 thyroid hormones Dab1 ---- Lrp8 Itgb1 ---- Reln Itga3 ---- Reln Reln ---- Vldlr Lrp8 ---- Reln Dab1 ---- PtdIns4P PAFAH1B1 ---> brain development PAFAH1B1 ---> neuronal migration Itgb1 ---> integrin mediated signaling pathway brain development Pik3r1 Ca2+ ---> learning and/or memory learning and/or memory neuronal migration PtdIns4P Reln Gria1 Grin2a Grin2b Lrp8 Vldlr Itga3 Itgb1 Pafah1b2 Grin2a --+> Ca2+ Grin2b --+> Ca2+ Itgb1 --+> Dab1 Itga3 --+> Dab1 Dab1 Dab1 --+> Src-related kinases Pik3r1 ---> phosphatidylinositol 3-kinase-Akt signaling pathway Fyn --+> Dab1 Fyn Dab1 --+> Fyn Src-related kinases --+> Dab1 integrin mediated signaling pathway Gria1 --+> synaptic transmission synaptic transmission thyroid hormones --+> Reln Pafah1b2 ---- Vldlr PAFAH1B3 ---- Vldlr Dab1 ---- PAFAH1B1 Dab1 ---- Gria1 Ca2+
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Genes in Pathway:

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Reelin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 JBrowse link 2 187,964,100 188,022,847 RGD:6484113
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:6484113
G Cdk5 cyclin-dependent kinase 5 JBrowse link 4 7,282,945 7,287,427 RGD:6484113
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 JBrowse link 10 67,862,054 67,863,255 RGD:6484113
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:6484113
G Dab1 DAB1, reelin adaptor protein JBrowse link 5 123,154,360 124,279,170 RGD:727518
RGD:6484113
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:2324970
RGD:6484113
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 10 42,441,723 42,760,200 RGD:2325284
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:2325284
RGD:6484113
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 4 169,541,620 170,000,216 RGD:2325284
RGD:6484113
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6484113
G Itga3 integrin subunit alpha 3 JBrowse link 10 82,855,841 82,887,755 RGD:2325851
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:2325851
RGD:6484113
G Lrp8 LDL receptor related protein 8 JBrowse link 5 127,404,348 127,476,636 RGD:2324974
RGD:6484113
G Lrpap1 LDL receptor related protein associated protein 1 JBrowse link 14 80,911,281 80,923,290 RGD:6484113
G Map1b microtubule-associated protein 1B JBrowse link 2 29,675,391 29,768,750 RGD:6484113
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6484113
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 1 221,043,119 221,056,420 RGD:6484113
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6484113
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6484113
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:6484113
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 JBrowse link 10 61,456,144 61,577,412 RGD:4107040
RGD:6484113
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 JBrowse link 8 50,256,969 50,310,043 RGD:4107040
G Pafah1b3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 JBrowse link 1 82,163,733 82,166,259 RGD:4107040
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:4108507
RGD:6484113
G Rap1a RAP1A, member of RAS oncogene family JBrowse link 2 208,193,950 208,215,186 RGD:6484113
G Reln reelin JBrowse link 4 9,347,533 9,774,257 RGD:727518
RGD:6484113
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:2325284
G Vldlr very low density lipoprotein receptor JBrowse link 1 245,236,819 245,273,688 RGD:727518
RGD:6484113
altered Reelin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dab1 DAB1, reelin adaptor protein JBrowse link 5 123,154,360 124,279,170 RGD:727518
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:2324970
G Itga3 integrin subunit alpha 3 JBrowse link 10 82,855,841 82,887,755 RGD:2325851
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:2325851
G Lrp8 LDL receptor related protein 8 JBrowse link 5 127,404,348 127,476,636 RGD:2324974
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 JBrowse link 10 61,456,144 61,577,412 RGD:4107040
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 JBrowse link 8 50,256,969 50,310,043 RGD:4107040
G Pafah1b3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 JBrowse link 1 82,163,733 82,166,259 RGD:4107040
G Reln reelin JBrowse link 4 9,347,533 9,774,257 RGD:727518
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:2325284
G Vldlr very low density lipoprotein receptor JBrowse link 1 245,236,819 245,273,688 RGD:1358468

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassSrc related Kinasesv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) related kinases

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Reelin signaling pathway
Disease TermsGene Symbols
Abnormalities, MultipleGrin2b , Gsk3b
Acute Kidney InjuryGsk3b
AdenocarcinomaPik3ca
Adenocarcinoma of EsophagusPik3ca
Adenocarcinoma of LungAkt1 , Pik3ca
Adenocarcinoma, ProstaticAkt1 , Pik3ca
Adenomatous Polyposis ColiAkt1
Adrenocortical CarcinomaPik3ca
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Aging, PrematureMapt
AlbuminuriaNck2
AlcoholismGrin2b
Alzheimer DiseaseAkt1 , Fyn , Gsk3b , Lrp8 , Lrpap1 , Mapk8 , Mapt , Pik3r1 , Reln , Vldlr
Amphetamine-Related DisordersAkt1
Amyotrophic Lateral SclerosisAkt1 , Cdk5 , Gsk3b
Angina, UnstableAkt1
Anterior Segment Dysgenesis 5Dab1
Anti-Glomerular Basement Membrane DiseaseMapk8
Aortic Aneurysm, AbdominalMapk8
Aortic Valve, Calcification ofAkt1
ArteriosclerosisVldlr
Arthritis, ExperimentalAkt1 , Cbl , Gsk3b
AstigmatismGrin2b
AstrocytomaAkt1
AtaxiaGrin2b , Reln
AtherosclerosisAkt1
Autism Spectrum DisorderGrin2b , Reln
Autistic DisorderDab1 , Gria1 , Grin2a , Reln , Vldlr
Bipolar DisorderAkt1 , Grin2a , Grin2b , Gsk3b , Reln
Brain DiseasesCdk5r1
Brain InjuriesAkt1 , Gsk3b , Map1b
Brain IschemiaAkt1 , Cdk5 , Mapk8 , Mapt , Src
Breast AdenocarcinomaAkt1 , Pik3ca
Breast NeoplasmsAkt1 , Crkl , Map2k7 , Mapt , Pik3ca , Pik3r1 , Src
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Akt1 , Pik3ca
Burkitt LymphomaPik3r1
BurnsFyn , Gsk3b
CalcinosisItgb1
CarcinogenesisGsk3b , Pafah1b1
CarcinomaPik3r1
Carcinoma in SituAkt1
Carcinoma, Adenoid CysticPik3ca
Carcinoma, Basal CellPik3ca
Carcinoma, Ductal, BreastCrkl
Carcinoma, HepatocellularAkt1 , Pafah1b1 , Pik3ca
Carcinoma, Intraductal, NoninfiltratingSrc
Carcinoma, Non-Small-Cell LungAkt1 , Cbl , Itgb1 , Pik3ca
Carcinoma, Renal CellAkt1 , Pik3ca
Carcinoma, Squamous CellAkt1 , Itgb1 , Pik3ca
Carcinoma, Squamous Cell of Head and NeckAkt1 , Pik3ca
CardiomegalyAkt1 , Gsk3b , Itga3 , Mapk8 , Src , Vldlr
CardiomyopathiesAkt1 , Itgb1
Cardiomyopathy, DilatedItgb1
Carotid Artery InjuriesCbl
CatalepsyFyn
Cell Transformation, NeoplasticMapk8
Central Nervous System Viral DiseasesGria1 , Grin2a
Cerebellar HypoplasiaVldlr
Ceroid Lipofuscinosis, Neuronal, 6Gsk3b
Classical Lissencephalies and Subcortical Band HeterotopiasPafah1b1
Cocaine-Related DisordersCdk5 , Gria1
Cognition DisordersCdk5r1 , Mapt
ColitisSrc
Colonic NeoplasmsAkt1 , Crkl , Pik3ca , Pik3r1 , Src
Colorectal NeoplasmsAkt1 , Grin2a , Pik3ca , Pik3r1
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Coronary Artery DiseaseAkt1 , Lrp8
COWDEN SYNDROME 5Pik3ca
CryptorchidismCbl
Currarino TriadPik3ca
DementiaLrp8 , Lrpap1 , Mapt , Vldlr
Depressive DisorderGsk3b , Reln
Depressive Disorder, MajorReln
Dermatitis, AtopicMapk8
Developmental DisabilitiesCbl , Grin2a
Diabetes Mellitus, ExperimentalAkt1 , Grin2b , Itga3 , Itgb1 , Pik3r1 , Vldlr
Diabetes Mellitus, Type 1Cbl
Diabetes Mellitus, Type 2Akt1 , Gsk3b , Pik3r1 , Src
DiGeorge SyndromeCrkl
Disease Models, AnimalAkt1 , Mapk8 , Mapt
Dysequilibrium syndromeVldlr
Egg HypersensitivityGrin2b
Encephalomyelitis, Autoimmune, ExperimentalMapt
Endometrial NeoplasmsPik3ca
EndometriosisItgb1
Epidermal NevusPik3ca
Epilepsies, PartialGrin2a
EpilepsyAkt1 , Gria1 , Grin2a , Grin2b
EPILEPSY, FAMILIAL TEMPORAL LOBE, 7Reln
Epilepsy, GeneralizedGrin2a , Grin2b
Epilepsy, RolandicGrin2a
Epilepsy, Temporal LobeFyn , Reln
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 27Grin2b
Erectile DysfunctionAkt1
Essential TremorMapt
Facial AsymmetryPik3ca
Fatty LiverMapk8
Fetal Growth RetardationGria1 , Grin2a
FibrosisAkt1 , Map2k7
Frontotemporal DementiaMapt
Gastrointestinal NeoplasmsPik3ca
Genetic Diseases, InbornGrin2a , Grin2b
GlioblastomaAkt1 , Pik3ca , Pik3r1
GliomaPik3ca
GliosisItgb1 , Mapt
GlomerulonephritisItga3 , Itgb1
Glomerulonephritis, MembranousLrpap1
Glomerulosclerosis, Focal SegmentalVldlr
Growth DisordersCbl , Pik3ca
Hamartoma Syndrome, MultipleAkt1 , Pik3ca
Head and Neck NeoplasmsPik3ca
Hearing Loss, Cisplatin-InducedGsk3b
Heart ArrestAkt1
Heart FailureCbl , Gsk3b , Itgb1 , Map2k7
Hematologic NeoplasmsCbl
HemimegalencephalyPik3ca
Hepatic EncephalopathyGria1
Hernias, Diaphragmatic, CongenitalCbl
HydrocephalusItgb1
HyperalgesiaGrin2b , Itga3 , Itgb1 , Mapk8
HypercholesterolemiaVldlr
HyperglycemiaCbl
HyperkinesisGria1
HyperlipidemiasVldlr
HyperoxaluriaRap1a
HyperplasiaAkt1 , Pik3ca
HypertensionAkt1 , Gsk3b , Mapk8 , Pik3r1 , Src
Hypertension, PortalPik3r1
HypertriglyceridemiaVldlr
Hypertrophy, Right VentricularAkt1
HypoglycemiaGrin2b , Pik3r1
HypotensionGria1 , Grin2b
HypothyroidismMap1b , Reln
Hypoxia-Ischemia, BrainGrin2a , Grin2b
Immunodeficiency 36Pik3r1
InflammationAkt1
Insulin ResistancePik3r1
Intellectual DisabilityGrin2a , Grin2b , Mapt
Interstitial Lung Disease, Nephrotic Syndrome, and Epidermolysis Bullosa, CongenitalItga3
Intervertebral Disc DisplacementAkt1
Ischemic Attack, TransientCbl
Joint InstabilityGrin2b
Keratosis, SeborrheicPik3ca
Kidney NeoplasmsAkt1
Kidney Reperfusion InjurySrc
Landau-Kleffner SyndromeGrin2a , Grin2b
Language Development DisordersGrin2a , Grin2b
Learning DisordersGria1 , Mapt , Pafah1b1
Leukemia, ExperimentalCbl
Leukemia, Lymphocytic, Chronic, B-CellCbl
Leukemia, Myeloid, AcuteCbl
Leukemia, Myelomonocytic, JuvenileCbl
Leukemia, Promyelocytic, AcuteAkt1
Leukemia-Lymphoma, Adult T-CellFyn
LissencephalyPafah1b1 , Reln
Liver CirrhosisReln
Liver Cirrhosis, ExperimentalFyn , Itgb1 , Reln
Liver Failure, AcuteMapk8
Liver NeoplasmsAkt1 , Pik3ca
Liver Reperfusion InjuryMapk8
Lung NeoplasmsAkt1 , Crkl , Map2k7 , Pik3ca
LymphomaPafah1b2
Lymphoma, Large B-Cell, DiffusePik3ca
Lymphoma, Mantle-CellGsk3b
Lymphoma, Non-HodgkinPik3ca
Lymphoma, T-CellAkt1
Lymphoma, T-Cell, PeripheralFyn
LymphopeniaCbl
Malformations of Cortical DevelopmentPik3ca
Mammary Neoplasms, AnimalPik3r1
Mammary Neoplasms, ExperimentalAkt1 , Map2k7 , Pik3r1
Marijuana AbuseAkt1
MedulloblastomaPik3ca
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca
MelanomaAkt1 , Cbl , Grin2a , Pik3ca , Pik3r1
Melanoma, Cutaneous Malignant, Susceptibility To, 1Akt1 , Cbl , Pik3ca
Memory DisordersMapt
Meningeal NeoplasmsAkt1
MeningiomaAkt1
Mental Retardation, Autosomal Dominant 6Grin2b
Metabolic Syndrome XLrpap1
Mood DisordersAkt1
Morphine DependenceGria1 , Grin2a
Motor Skills DisordersPafah1b1
Mouth NeoplasmsPik3ca
Multiple MyelomaCbl , Pik3ca
Muscular AtrophyAkt1 , Gsk3b
Myeloproliferative DisordersCbl
Myocardial InfarctionAkt1 , Gsk3b , Itga3 , Lrp8 , Lrpap1
Myocardial Reperfusion InjuryAkt1 , Cbl , Gsk3b , Mapk8 , Rap1a
Myopia 23, Autosomal RecessiveLrpap1
Nasopharyngeal carcinomaPik3ca
Nasopharyngeal NeoplasmsPik3ca
Nematode InfectionsPik3r1
Neoplasm InvasivenessItgb1 , Src
Neoplasm MetastasisItgb1 , Src
NeoplasmsPik3ca , Pik3r1 , Src
Neoplastic Syndromes, HereditaryPik3ca
Nephrotic SyndromeNck2 , Vldlr
Nerve DegenerationCdk5r1 , Lrp8
Nervous System MalformationsPafah1b1 , Reln
NeuroblastomaPik3ca
Neurodegenerative DiseasesMapt
Noonan like syndromeCbl
Noonan SyndromeCbl
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaCbl
Norman Roberts Lissencephaly SyndromeReln
ObesityAkt1 , Pik3r1 , Vldlr
Osteoarthritis, ExperimentalLrpap1
OsteosarcomaAkt1
Ovarian Epithelial CancerPik3ca
Ovarian NeoplasmsAkt1 , Crkl , Map2k7 , Pik3ca , Pik3r1
Oxygen-Induced RetinopathyMapk8
PainAkt1
Pancreatic AdenocarcinomaPik3ca
Papillary Renal Cell Carcinoma, SporadicPik3ca
ParaplegiaAkt1
Parkinson DiseaseAkt1 , Gsk3b , Mapt
Parkinson Disease, Late-OnsetMapt
Parkinsonian DisordersMapt , Src
Penile NeoplasmsPik3ca
PeritonitisGsk3b
Pick Disease of the BrainMapt
Placental InsufficiencyGrin2a , Grin2b
Pleomorphic Xanthoastrocytoma Reln
PoisoningGsk3b
Polycystic Kidney, Autosomal RecessiveAkt1 , Pik3ca , Src
Precancerous ConditionsMap2k7 , Mapk8
Primary ciliary dyskinesia, 2Dab1
Progressive Supranuclear Palsy AtypicalMapt
Prostatic Intraepithelial NeoplasiaMap2k7
Prostatic NeoplasmsAkt1 , Crkl , Gsk3b , Lrpap1 , Map2k7 , Mapt , Pik3ca , Pik3r1 , Src
ProteinuriaNck2
Proteus SyndromeAkt1
Psychomotor AgitationMapt
Psychoses, Substance-InducedAkt1
Pulmonary Disease, Chronic ObstructiveMapk8
RASopathiesCbl
Rectal NeoplasmsPik3ca
Reperfusion InjuryAkt1 , Gria1 , Grin2a , Grin2b , Mapk8 , Pik3r1 , Src
Respiratory InsufficiencyMapt
Rolandic Epilepsy, Mental Retardation, and Speech Dyspraxia, Autosomal DominantGrin2a , Grin2b
SarcomaPik3ca
SchizophreniaAkt1 , Crkl , Fyn , Grin2a , Grin2b , Gsk3b , Lrp8 , Pafah1b1 , Reln
SeizuresGria1 , Map1b , Pafah1b1
SepsisFyn , Grin2a , Gsk3b
Septic PeritonitisPik3r1
Sexual Dysfunctions, PsychologicalGria1
SHORT SyndromePik3r1
Skin NeoplasmsAkt1 , Crkl
Sleep DeprivationGrin2b
Small Cell Lung CarcinomaAkt1 , Pik3ca
Smith-Magenis SyndromeCdk5r1 , Itga3 , Mapt
Speech DisordersGrin2a
Spinal Cord InjuriesAkt1 , Map1b , Mapt
SplenomegalyMapt
Squamous Cell Carcinoma of the LungAkt1 , Pik3ca
Status EpilepticusDab1 , Gria1 , Gsk3b , Reln , Src
Stomach NeoplasmsFyn , Mapk8 , Pik3ca
StrokeAkt1 , Mapk8 , Src
Substance Withdrawal SyndromeGria1 , Grin2a
Supranuclear Palsy, ProgressiveMapt
TauopathiesMapt
ThrombosisLrp8
Trauma, Nervous SystemGrin2b
Trigeminal NeuralgiaMapk8
Ureteral ObstructionAkt1
Urinary Bladder NeoplasmsAkt1 , Src
Uterine Cervical NeoplasmsAkt1 , Pik3ca
VasculitisCbl
Ventilator-Induced Lung InjuryAkt1
Weight GainPik3ca
Weight LossMapt
Wet Macular DegenerationMapk8
Pathway Annotations Associated with Genes in the Reelin signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Pik3ca , Pik3r1
adenosine signaling pathwayAkt1 , Map2k7 , Mapk8 , Pik3ca , Rap1a
aldosterone signaling pathwayPik3ca , Pik3r1
alfentanil pharmacodynamics pathwayGrin2a
altered integrin mediated signaling pathwayItgb1
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Pik3ca
altered Reelin signaling pathwayDab1 , Fyn , Itga3 , Itgb1 , Lrp8 , Pafah1b1 , Pafah1b2 , Pafah1b3 , Reln , Src , Vldlr
Alzheimer disease pathwayCdk5 , Cdk5r1 , Grin2a , Grin2b , Gsk3b , Mapt
amyotrophic lateral sclerosis disease pathwayGria1 , Grin2a , Grin2b
apoptotic cell death pathwayAkt1 , Pik3ca , Pik3r1
arrhythmogenic right ventricular cardiomyopathy pathwayItgb1
B cell receptor signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1
basal cell carcinoma pathwayGsk3b
Bone morphogenetic proteins signaling pathwayGsk3b
bupivacaine pharmacodynamics pathwayGrin2a
buprenorphine pharmacodynamics pathwayGrin2a
c-Jun N-terminal kinases MAPK signaling pathwayMap2k7 , Map3k11 , Mapk8
calcium/calcium-mediated signaling pathwayGrin2a
calcium/calmodulin dependent kinase 2 signaling pathwayGria1 , Grin2a , Grin2b
cell cycle pathway, mitoticGsk3b
cell-extracellular matrix signaling pathwayItgb1 , Reln
ceramide signaling pathwayAkt1 , Mapk8 , Pik3ca , Pik3r1
chemokine mediated signaling pathwayAkt1 , Crkl , Gsk3b , Pik3ca , Pik3r1 , Rap1a
chloroprocaine pharmacodynamics pathwayGrin2a
chronic myeloid leukemia pathwayAkt1 , Cbl , Crkl , Pik3ca , Pik3r1
citalopram pharmacodynamics pathwayGrin2a
cocaine pharmacodynamics pathwayGrin2a
codeine and morphine pharmacodynamics pathwayGrin2a
colorectal cancer pathwayAkt1 , Gsk3b , Mapk8 , Pik3ca , Pik3r1
desipramine pharmacodynamics pathwayGrin2a
dilated cardiomyopathy pathwayItgb1
diphenoxylate pharmacodynamics pathwayGrin2a
dopamine signaling pathwayCdk5 , Src
E-cadherin signaling pathwayAkt1 , Fyn , Pik3ca , Pik3r1 , Rap1a , Src
eicosanoid signaling pathwayAkt1 , Fyn , Src
endocytosis pathwayCbl , Src
endometrial cancer pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1
Endoplasmic Reticulum-associated degradation pathwayMap2k7 , Mapk8
endothelin signaling pathwayAkt1 , Mapk8 , Src
Entamoeba histolyca infection pathwayPik3ca , Pik3r1
ephrin - ephrin receptor bidirectional signaling axisCbl , Cdk5 , Crkl , Fyn , Gria1 , Mapk8 , Nck2 , Pik3ca , Pik3r1 , Rap1a , Src
epidermal growth factor/neuregulin signaling pathwayAkt1 , Cbl , Crkl , Gsk3b , Map2k7 , Mapk8 , Nck2 , Pik3ca , Pik3r1 , Src
erythropoietin signaling pathwayCbl , Crkl , Mapk8 , Pik3r1 , Rap1a
escitalopram pharmacodynamics pathwayGrin2a
estrogen signaling pathwaySrc
ether lipid metabolic pathwayPafah1b1 , Pafah1b2 , Pafah1b3
ether lipid metabolic pathwayPafah1b1 , Pafah1b2 , Pafah1b3
ethylmorphine pharmacodynamics pathwayGrin2a
excitatory synaptic transmission pathwayGrin2a , Grin2b
FasL mediated signaling pathwayAkt1 , Map2k7 , Mapk8 , Pik3ca , Pik3r1 , Src
Fc epsilon receptor mediated signaling pathwayAkt1 , Fyn , Map2k7 , Mapk8 , Pik3ca , Pik3r1
Fc gamma receptor mediated signaling pathwayAkt1 , Crkl , Pik3ca , Pik3r1
fentanyl pharmacodynamics pathwayGrin2a
fibroblast growth factor signaling pathwayAkt1 , Cbl , Pik3ca , Pik3r1 , Src
fluoxetine pharmacodynamics pathwayGrin2a
forkhead class A signaling pathwayAkt1
glioma pathwayAkt1 , Pik3ca , Pik3r1
glomerulonephritis pathwayItgb1
glutamate signaling pathwayGria1 , Grin2a , Grin2b
glycogen biosynthetic pathwayGsk3b
glypican signaling pathwayFyn , Mapk8 , Src
gonadotropin-releasing hormone signaling pathwayMap2k7 , Mapk8 , Src
granulocyte-macrophage colony-stimulating factor signaling pathwayPik3ca , Pik3r1
Hedgehog signaling pathwayAkt1 , Gsk3b , Lrpap1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayAkt1 , Gsk3b , Mapk8 , Pik3ca , Pik3r1
heroin pharmacodynamics pathwayGrin2a
Huntington disease pathwayGrin2b
hydrocodone pharmacodynamics pathwayGrin2a
hydromorphone pharmacodynamics pathwayGrin2a
hypertrophic cardiomyopathy pathwayItgb1
hypoxia inducible factor pathwayAkt1
imipramine pharmacodynamics pathwayGrin2a
inflammatory response pathwayMapk8
influenza A virus infection pathwayAkt1 , Gsk3b , Map2k7 , Mapk8 , Pik3ca , Pik3r1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Cbl , Gsk3b
insulin signaling pathwayAkt1 , Cbl , Crkl , Gsk3b , Mapk8 , Nck2 , Pik3ca , Pik3r1
insulin-like growth factor signaling pathwayAkt1 , Crkl , Nck2 , Pik3ca , Pik3r1
integrin mediated signaling pathwayItga3 , Itgb1 , Nck2
interleukin-1 signaling pathwayMapk8 , Pik3ca , Pik3r1
interleukin-2 signaling pathwayFyn , Mapk8 , Pik3ca , Pik3r1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Cbl , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Pik3ca , Pik3r1
Jak-Stat signaling pathwayAkt1 , Cbl , Pik3ca , Pik3r1
Leishmania infection pathwayItgb1
levacetylmethadol pharmacodynamics pathwayGrin2a
levobupivacaine phgarmacodynamics pathwayGrin2a
levorphanol pharmacodynamics pathwayGrin2a
lidocaine pharmacodynamics pathwayGrin2a
long term depressionGria1 , Grin2a , Gsk3b
long term potentiationGria1 , Grin2a , Grin2b , Rap1a
measles infection pathwayAkt1 , Fyn , Gsk3b , Pik3ca , Pik3r1
melanoma pathwayAkt1 , Pik3ca , Pik3r1
mepivacaine pharmacodynamics pathwayGrin2a
methadone pharmacodynamics pathwayGrin2a
methadone pharmacokinetics pathwayGrin2a
mitochondrial autophagy pathwaySrc
mitogen activated protein kinase signaling pathwayAkt1 , Crkl , Map2k7 , Map3k11 , Mapk8 , Mapt , Rap1a
mTOR signaling pathwayAkt1 , Pik3ca , Pik3r1
Mycobacterium tuberculosis infection pathwayAkt1 , Mapk8 , Src
myocarditis pathwayFyn
N-cadherin signaling pathwayMapk8 , Pik3ca , Pik3r1
nalbuphine pharmacodynamics pathwayGrin2a
naloxone pharmacodynamics pathwayGrin2a
naltrexone pharmacodynamics pathwayGrin2a
nerve growth factor signaling pathwaySrc
neurotrophic factor signaling pathwayAkt1 , Crkl , Gsk3b , Map2k7 , Mapk8 , Pik3ca , Pik3r1 , Rap1a
nicotine pharmacodynamics pathwayGrin2a
NOD-like receptor signaling pathwayMapk8
non-small cell lung cancer pathwayAkt1 , Pik3ca , Pik3r1
Notch signaling pathwayCbl
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1 , Src
nuclear factor, erythroid 2 like 2 signaling pathwayGsk3b
oxybuprocaine pharmacodynamics pathwayGrin2a
oxycodone pharmacodynamics pathwayGrin2a
oxymorphone pharmacodynamics pathwayGrin2a
p38 MAPK signaling pathwayMap3k11
p53 signaling pathwayAkt1 , Gsk3b , Mapk8
pancreatic cancer pathwayAkt1 , Mapk8 , Pik3ca , Pik3r1
pentazocine pharmacodynamics pathwayGrin2a
phagocytosis pathwayItgb1
phosphatidylinositol 3-kinase class I signaling pathwayFyn , Pik3ca , Pik3r1 , Rap1a , Src
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3r1
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1 , Src
phosphoinositide metabolic pathwayPik3ca , Pik3r1
platelet-derived growth factor signaling pathwayCbl , Crkl , Fyn , Map2k7 , Mapk8 , Nck2 , Pik3ca , Pik3r1 , Rap1a , Src
prilocaine pharmacodynamics pathwayGrin2a
prion diseases pathwayFyn
procaine pharmacodynamics pathwayGrin2a
prostate cancer pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1
protein kinase C (PKC) signaling pathwayFyn
Reelin signaling pathwayAkt1 , Arhgef2 , Cbl , Cdk5 , Cdk5r1 , Crkl , Dab1 , Fyn , Gria1 , Grin2a , Grin2b , Gsk3b , Itga3 , Itgb1 , Lrp8 , Lrpap1 , Map1b , Map2k7 , Map3k11 , Mapk8 , Mapt , Nck2 , Pafah1b1 , Pafah1b2 , Pafah1b3 , Pik3ca , Pik3r1 , Rap1a , Reln , Src , Vldlr
remifentanil pharmacodynamics pathwayGrin2a
renal cell cancer pathwayAkt1 , Crkl , Pik3ca , Pik3r1 , Rap1a
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMapk8
Rho/Rac/Cdc42 mediated signaling pathwayCbl , Mapk8
ropivacaine pharmacodynamics pathwayGrin2a
scatter factor/hepatocyte growth factor signaling pathwayCbl , Crkl , Pik3r1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
small cell lung cancer pathwayAkt1 , Itgb1 , Pik3ca , Pik3r1
somatostatin signaling pathwaySrc
sphingosine 1-phosphate signaling pathwayAkt1 , Mapk8 , Src
syndecan signaling pathwayFyn , Itgb1 , Mapk8 , Src
systemic lupus erythematosus pathwayGrin2a , Grin2b
T cell receptor signaling pathwayAkt1 , Cbl , Fyn , Gsk3b , Map2k7 , Nck2 , Pik3ca , Pik3r1
Toll-like receptor signaling pathwayAkt1 , Map2k7 , Mapk8 , Pik3ca , Pik3r1
Toxoplasma gondii infection pathwayAkt1 , Itgb1 , Mapk8 , Pik3ca , Pik3r1
Trail mediated signaling pathwayMapk8 , Pik3ca , Pik3r1
tramadol pharmacodynamics pathwayGrin2a
Trypanosoma cruzi infection pathwayAkt1 , Mapk8 , Pik3ca , Pik3r1
tumor necrosis factor mediated signaling pathwayMap2k7
type 2 diabetes mellitus pathwayMapk8 , Pik3ca , Pik3r1
type II interferon signaling pathwayAkt1 , Cbl , Crkl , Map3k11 , Pik3ca , Pik3r1 , Rap1a
ubiquitin/proteasome degradation pathwayCbl , Src
vascular endothelial growth factor signaling pathwayAkt1 , Cbl , Fyn , Nck2 , Pik3ca , Pik3r1 , Src
Wnt signaling pathwayGsk3b , Mapk8
Wnt signaling, canonical pathwayGsk3b
Wnt signaling, non-canonical pathwayMapk8
Phenotype Annotations Associated with Genes in the Reelin signaling pathway

References Associated with the Reelin signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: