LEPTIN SYSTEM PATHWAY (PW:0000363)

View Ontology Report

Description

The leptin system plays an essential role in energy homeostasis - the balance between energy intake and expenditure. Leptin acts on two classes of neurons: those expressing the appetite decreasing peptides POMC and CART and those expressing the appetite stimulating peptides NPY and AgRP, promoting the upregulation of the former and downregulation of the latter. The products of the Pomc and Agrp genes act on melanocortin receptors as agonists and antagonists, respectively and the le

Pathway Diagram:

Ariadne Genomics Inc. PY1138 PY985 Stat3 Lepr --+> Jak2 Jak2 Lepr Ptpn11 Socs3 ---| Lepr Jak2 --+> Irs2 Lepr --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Lep phosphatidylinositol 3-kinase-Akt signaling pathway leptin activated Stat3 gene targets ---> Socs3 Socs3 Ptpn1 Lepr ---- Stat3 Lep ---- Lepr Jak2 --+> Lepr Jak2 --+> Irs1 Jak2 ---- Lepr Jak2 ---- Sh2bpsm1 Irs1 ---- Sh2bpsm1 Irs2 ---- Sh2bpsm1 Jak2 ---- Ptpn11 Lepr ---- Ptpn11 Stat3 ---> leptin activated Stat3 gene targets the extracellular signal-regulated Raf/Mek/Erk signaling pathway Ptpn1 ---| Stat3 Ptpn1 ---| Jak2 Irs2 Irs1 Sh2bpsm1 Jak-Stat signaling pathway Socs3 ---| Jak2 Jak2 --+> Stat3 leptin activated Stat3 gene targets Lepr --+> phosphatidylinositol 3-kinase-Akt signaling pathway Jak2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns
leptin system pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:2302071
G Irs2 insulin receptor substrate 2 JBrowse link 16 83,824,515 83,848,569 RGD:2302071
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1625125
RGD:2302071
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:61790
RGD:1625125
RGD:2290293
RGD:2290294
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:61790
RGD:1600611
RGD:1625125
RGD:2290293
RGD:2290294
G Lepr_v1 leptin receptor, variant 1 RGD:2290293
RGD:2290294
G Lepr_v2 leptin receptor, variant 2 RGD:2290292
RGD:2290293
RGD:2290294
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:2289366
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:2289807
G Sh2b1 SH2B adaptor protein 1 JBrowse link 1 197,878,839 197,888,223 RGD:2302071
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:1625125
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:1600611
RGD:1625125
altered leptin system pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:2290473
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:61790
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:61790
RGD:1600611
G Lepr_v2 leptin receptor, variant 2 RGD:2290292

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupLeptin activated Stat3 gene targetsLeptin activated Stat3 gene targets

Pathway Gene Annotations

Disease Annotations Associated with Genes in the leptin system pathway
Disease TermsGene Symbols
Abortion, SpontaneousJak2
AdenocarcinomaPtpn11 , Stat3
Adenocarcinoma of LungPtpn11
ADENOCARCINOMA OF STOMACHPtpn11
AIDS Dementia ComplexIrs1
AlbuminuriaLepr
Alzheimer DiseaseIrs1 , Irs2 , Jak2 , Lep , Stat3
AnemiaJak2
AngiomyolipomaStat3
Aortic Valve InsufficiencyPtpn11
Aortic Valve StenosisPtpn11
ArteriosclerosisLepr
Arthritis, ExperimentalJak2 , Lep , Socs3 , Stat3
Arthritis, JuvenileStat3
Arthritis, PsoriaticStat3
Arthritis, RheumatoidJak2 , Stat3
AsthmaLep
AstrocytomaPtpn11
AtherosclerosisSocs3 , Stat3
AtrophyStat3
Autistic DisorderLep , Stat3
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1Stat3
Autoimmune DiseasesStat3
Behcet SyndromeStat3
Body Mass Index Quantitative Trait Locus 10Lepr
Body Mass Index Quantitative Trait Locus 11Lepr
Body Mass Index Quantitative Trait Locus 12Lepr
Body Mass Index Quantitative Trait Locus 14Lepr
Body Mass Index Quantitative Trait Locus 4Lepr
Body Mass Index Quantitative Trait Locus 7Lepr
Body Mass Index Quantitative Trait Locus 8Lepr
Body Mass Index Quantitative Trait Locus 9Lepr
Body Weight ChangesLep
Brain InjuriesJak2 , Lep , Stat3
Brain IschemiaStat3
Breast NeoplasmsLep , Lepr , Stat3
Budd-Chiari SyndromeJak2
BurnsSocs3
CalcinosisJak2
CarcinomaStat3
Carcinoma, Ductal, BreastSocs3
Carcinoma, HepatocellularIrs1 , Irs2 , Socs3
Carcinoma, Intraductal, NoninfiltratingSocs3
Carcinoma, Non-Small-Cell LungLep , Stat3
Carcinoma, Renal CellLep , Stat3
Carcinoma, Squamous CellPtpn11 , Stat3
Carcinoma, Squamous Cell of Head and NeckStat3
Cardiofaciocutaneous SyndromePtpn11
CardiomegalyStat3
CardiomyopathiesStat3
Cardiomyopathy, DilatedLepr , Ptpn11
Cardiomyopathy, HypertrophicPtpn11
Cell Transformation, NeoplasticIrs1 , Stat3
Cervical Intraepithelial NeoplasiaStat3
Choroidal NeovascularizationLep , Stat3
Chronic Lymphoid LeukemiaPtpn11
Churg-Strauss SyndromeStat3
Colonic NeoplasmsLep , Stat3
Colorectal NeoplasmsPtpn11
Copper-Overload CirrhosisStat3
Coronary Artery DiseaseIrs1
Coronary DiseaseIrs1
Costello SyndromePtpn11
Crohn DiseaseJak2 , Lep , Stat3
Cystic FibrosisLep
Dermatitis, IrritantStat3
Diabetes MellitusIrs1 , Lep , Lepr
Diabetes Mellitus, ExperimentalIrs1 , Irs2 , Lep , Lepr , Socs3 , Stat3
Diabetes Mellitus, Type 1Stat3
Diabetes Mellitus, Type 2Irs1 , Irs2 , Lep , Lepr , Ptpn1 , Socs3 , Stat3
Diabetes, GestationalLep , Lepr
Diabetic NephropathiesIrs2 , Jak2 , Lep , Stat3
Diabetic NeuropathiesLepr
Disease Models, AnimalStat3
Duodenal UlcerStat3
DyslipidemiasLepr
Encephalomyelitis, Autoimmune, ExperimentalJak2 , Stat3
EnchondromatosisPtpn11
Endometrial NeoplasmsSocs3 , Stat3
EndotoxemiaIrs1 , Socs3
Epidermal HyperplasiaStat3
Erythrocytosis, Familial, 1Jak2
Erythrocytosis, Familial, 2Jak2
Exostoses, Multiple HereditaryPtpn11
Fatty LiverJak2 , Lep , Lepr , Socs3
Femoral FracturesLep
Fetal Growth RetardationIrs1 , Irs2 , Lep , Ptpn11
FeverStat3
FibrosisLepr , Socs3 , Stat3
Glucose IntoleranceJak2 , Lep , Lepr
Granuloma, PyogenicStat3
Growth DisordersJak2
Growth Hormone-Secreting Pituitary AdenomaPtpn11
Heart DiseasesJak2 , Stat3
Heart FailureLep , Lepr
Heart Valve DiseasesJak2
Helicobacter InfectionsSocs3
HemangiosarcomaStat3
Hepatitis C, ChronicStat3
Hepatitis, AutoimmuneLep
Hepatitis, ChronicStat3
HepatomegalyLepr
Hernias, Diaphragmatic, CongenitalStat3
Heroin DependenceLep
HIV InfectionsSocs3
Hodgkin DiseasePtpn1
Huntington DiseaseLep
Hyper-Ige Recurrent Infection Syndrome, Autosomal DominantStat3
HyperalgesiaJak2 , Stat3
HypercapniaLep
HypercholesterolemiaLep
HyperglycemiaIrs2 , Lepr
HyperinsulinismIrs1 , Lep , Lepr
HyperlipidemiasIrs1 , Lep , Lepr
HyperphagiaLep , Lepr
HyperplasiaLep
HypertensionLep , Lepr
HypertriglyceridemiaLep , Socs3
Hypertrophy, Left VentricularLepr
HyperuricemiaJak2 , Stat3
HypogonadismLep , Lepr
HypoventilationLep
Idiopathic Pulmonary FibrosisStat3
Immunologic Deficiency SyndromesLepr
Infarction, Middle Cerebral ArteryStat3
InfertilityLepr
Infertility, FemaleLep , Lepr
InflammationJak2 , Lep , Stat3
Inflammatory Bowel Disease 11Jak2 , Stat3
Insulin ResistanceIrs1 , Irs2 , Lep , Lepr , Ptpn1 , Socs3
Intestinal Reperfusion InjuryJak2
Ischemic Attack, TransientJak2 , Stat3
Job SyndromeStat3
Kidney DiseasesLepr
Kidney Failure, ChronicIrs1 , Lep
Kidney Reperfusion InjuryLep
LEOPARD SyndromePtpn11
LEPTIN DEFICIENCY OR DYSFUNCTIONLep
Leptin Receptor DeficiencyLepr
LeukemiaJak2 , Ptpn11
Leukemia, Large Granular LymphocyticStat3
Leukemia, Lymphocytic, Chronic, B-CellPtpn11
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveJak2
Leukemia, Myeloid, AcuteJak2 , Ptpn11 , Stat3
Leukemia, Myelomonocytic, JuvenilePtpn11
Leukemia, T-CellStat3
Leukemia-Lymphoma, Adult T-CellStat3
Liver CirrhosisStat3
Liver Cirrhosis, AlcoholicJak2
Liver Cirrhosis, BiliaryJak2 , Lep , Lepr
Liver Cirrhosis, ExperimentalJak2 , Lep , Lepr , Ptpn1
Liver DiseasesSocs3
Liver InjuryJak2 , Stat3
Liver NeoplasmsStat3
Liver Neoplasms, ExperimentalStat3
Liver Reperfusion InjuryJak2
Lung DiseasesLep
Lupus Erythematosus, SystemicJak2
LymphangioleiomyomatosisStat3
Lymphatic MetastasisSocs3 , Stat3
Lymphoblastic Leukemia, Acute, with Lymphomatous FeaturesJak2
Lymphoma, B-CellPtpn1
Lymphoma, Large-Cell, AnaplasticStat3
Lymphoma, T-CellStat3
Lymphoproliferative DisordersStat3
Mammary Neoplasms, AnimalStat3
Mammary Neoplasms, ExperimentalLep , Socs3 , Stat3
Mediastinal NeoplasmsPtpn1
MedulloblastomaIrs2 , Stat3
Melanoma, Cutaneous MalignantStat3
Memory DisordersStat3
Mesenteric Vascular OcclusionJak2
Metabolic Syndrome XIrs1 , Lep
Metabolism, Inborn ErrorsLepr
MetachondromatosisPtpn11
Multiple MyelomaPtpn11
Myeloproliferative DisordersJak2
Myocardial InfarctionJak2
Myocardial IschemiaJak2 , Lepr , Socs3
Myocardial Reperfusion InjuryJak2 , Lep , Lepr , Stat3
Nasal PolypsLepr , Stat3
Neoplasm MetastasisStat3
Nephrotic SyndromeJak2
Nerve DegenerationLep
NeuroblastomaPtpn11
Neurodevelopmental DisordersPtpn11
Niemann-Pick Disease, Type CJak2 , Stat3
Non-alcoholic Fatty Liver DiseaseIrs1 , Irs2 , Jak2 , Lep , Stat3
Noonan like syndromePtpn11
Noonan SyndromePtpn11
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaPtpn11
ObesityIrs1 , Irs2 , Jak2 , Lep , Lepr , Ptpn1 , Sh2b1 , Socs3 , Stat3
Obesity, MorbidLep , Lepr
Oral UlcerLep
OsteoarthritisLep
Osteoarthritis, KneeLep , Lepr
OsteochondromaPtpn11
OsteoporosisIrs1 , Irs2 , Lep , Lepr
Ovarian NeoplasmsStat3
OverweightLepr
Oxygen-Induced RetinopathyStat3
Pancreatic DiseasesLepr
Pancreatic NeoplasmsStat3
PancreatitisLepr
Parkinson DiseaseLep
Pituitary DiseasesLepr
Pleomorphic Xanthoastrocytoma Lep
Pneumonia, BacterialLep , Stat3
Pneumonia, PneumococcalLep , Lepr
Polycystic Ovary SyndromeLep
PolycythemiaJak2
Polycythemia VeraJak2
PolydipsiaLep
PolyuriaLep
Pre-EclampsiaLep , Lepr
Precancerous ConditionsIrs1 , Stat3
Precursor B-Cell Lymphoblastic Leukemia-LymphomaStat3
Precursor T-Cell Lymphoblastic Leukemia-LymphomaPtpn11
Pregnancy ComplicationsJak2
Primary MyelofibrosisJak2
Prostatic NeoplasmsIrs1 , Jak2 , Lep , Stat3
ProteinuriaLep , Lepr
PsoriasisStat3
Puberty, DelayedLepr
Pulmonary Disease, Chronic ObstructiveLep , Lepr
Pulmonary FibrosisLepr , Stat3
RASopathiesPtpn11
Reperfusion InjuryJak2 , Lep , Socs3 , Stat3
Respiratory Distress Syndrome, AdultLep
Respiratory Tract InfectionsLepr
Retina Reperfusion InjuryStat3
Retinal DetachmentJak2
Rett SyndromePtpn1
RhinitisLep
SchizophreniaSh2b1
Scleroderma, LimitedJak2
ScrapieJak2 , Stat3
SeizuresLep
SepsisIrs1 , Jak2 , Lep , Socs3 , Stat3
Sepsis-Associated EncephalopathyJak2 , Stat3
Short Bowel SyndromeLep , Lepr
Skin NeoplasmsStat3
Sleep Apnea SyndromesLepr
Sleep Apnea, ObstructiveLep , Lepr
Smith-Magenis SyndromeSocs3 , Stat3
Spinal Cord InjuriesJak2 , Lep
Spinal FracturesLepr
Spondylitis, AnkylosingJak2
Squamous Cell Carcinoma of the LungPtpn11
Status EpilepticusSocs3
Stomach NeoplasmsIrs2 , Stat3
Stomach UlcerLep
StrokeJak2
Subarachnoid HemorrhageStat3
TachycardiaLep
Tetralogy of FallotPtpn11
Thrombocythemia 3Jak2
Thrombocythemia, EssentialJak2
ThrombocytosisJak2
ThromboembolismJak2
Tongue NeoplasmsStat3
Uterine Cervical NeoplasmsJak2 , Stat3
Uveitis, Autoimmune, ExperimentalStat3
Uveoretinitis, Autoimmune, ExperimentalStat3
Varicose UlcerLepr
Venous ThrombosisJak2
Weight GainLep
Weight LossLep
Wilms TumorStat3
Pathway Annotations Associated with Genes in the leptin system pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayStat3
aldosterone signaling pathwayIrs1 , Irs2 , Jak2
altered energy homeostasis pathwayLep , Lepr
altered Jak-Stat signaling pathwayJak2
altered leptin system pathwayLep , Lepr , Lepr_v2
angiotensin II signaling pathwayJak2
angiotensin II signaling pathway via AT1 receptorJak2
ceramide signaling pathwayStat3
chemokine mediated signaling pathwayJak2 , Stat3
chronic myeloid leukemia pathwayPtpn11
cytokine mediated signaling pathwayLep , Lepr
endothelin signaling pathwayJak2
energy homeostasis pathwayLep , Lepr
epidermal growth factor/neuregulin signaling pathwayPtpn1 , Ptpn11 , Stat3
erythropoietin signaling pathwayIrs2 , Jak2 , Ptpn11 , Socs3
fibroblast growth factor signaling pathwayPtpn11
granulocyte-macrophage colony-stimulating factor signaling pathwayJak2 , Ptpn11 , Stat3
growth hormone signaling pathwayJak2
hepatitis C virus infection pathwaySocs3 , Stat3
hypoxia inducible factor pathwayLep
influenza A virus infection pathwayJak2 , Socs3
insulin signaling pathwayIrs1 , Irs2 , Ptpn1 , Ptpn11 , Socs3
insulin-like growth factor signaling pathwayIrs1 , Irs2 , Ptpn1 , Ptpn11
Interleukin-10 signaling pathwayStat3
interleukin-12 signaling pathwayJak2 , Stat3
interleukin-2 signaling pathwayIrs1 , Irs2 , Ptpn11 , Socs3 , Stat3
interleukin-23 signaling pathwayJak2 , Socs3 , Stat3
interleukin-27 signaling pathwayJak2 , Stat3
interleukin-3 signaling pathwayJak2 , Ptpn11
interleukin-4 signaling pathwayIrs1 , Irs2 , Jak2 , Socs3
interleukin-5 signaling pathwayJak2 , Ptpn11
interleukin-6 signaling pathwayJak2 , Ptpn11 , Socs3 , Stat3
Jak-Stat signaling pathwayJak2 , Lep , Lepr , Ptpn1 , Ptpn11 , Socs3 , Stat3
Leishmania infection pathwayJak2
leptin system pathwayIrs1 , Irs2 , Jak2 , Lep , Lepr , Lepr_v1 , Lepr_v2 , Ptpn1 , Ptpn11 , Sh2b1 , Socs3 , Stat3
measles infection pathwayJak2 , Stat3
mTOR signaling pathwayIrs1
Mycobacterium tuberculosis infection pathwayJak2
N-cadherin signaling pathwayPtpn1 , Ptpn11
neurotrophic factor signaling pathwayIrs1 , Irs2 , Ptpn11 , Sh2b1
obesity disease pathwayLepr , Lepr_v2
pancreatic cancer pathwayStat3
platelet-derived growth factor signaling pathwayJak2 , Ptpn1 , Ptpn11 , Stat3
renal cell cancer pathwayPtpn11
scatter factor/hepatocyte growth factor signaling pathwayPtpn11
somatostatin signaling pathwayJak2 , Ptpn11
sphingosine 1-phosphate signaling pathwayIrs1 , Jak2
Toxoplasma gondii infection pathwayJak2 , Stat3
type 2 diabetes mellitus pathwayIrs1 , Irs2 , Socs3
type II interferon signaling pathwayJak2 , Ptpn11 , Stat3
ubiquitin/proteasome degradation pathwaySocs3
vascular endothelial growth factor signaling pathwayPtpn11
Phenotype Annotations Associated with Genes in the leptin system pathway

References Associated with the leptin system pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: