LEPTIN SYSTEM PATHWAY (PW:0000363)

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Description

The leptin system plays an essential role in energy homeostasis - the balance between energy intake and expenditure. Leptin acts on two classes of neurons: those expressing the appetite decreasing peptides POMC and CART and those expressing the appetite stimulating peptides NPY and AgRP, promoting the upregulation of the former and downregulation of the latter. The products of the Pomc and Agrp genes act on melanocortin receptors as agonists and antagonists, respectively and the le

Pathway Diagram:

Ariadne Genomics Inc. PY1138 PY985 Stat3 Lepr --+> Jak2 Jak2 Lepr Ptpn11 Socs3 ---| Lepr Jak2 --+> Irs2 Lepr --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Lep phosphatidylinositol 3-kinase-Akt signaling pathway leptin activated Stat3 gene targets ---> Socs3 Socs3 Ptpn1 Lepr ---- Stat3 Lep ---- Lepr Jak2 --+> Lepr Jak2 --+> Irs1 Jak2 ---- Lepr Jak2 ---- Sh2bpsm1 Irs1 ---- Sh2bpsm1 Irs2 ---- Sh2bpsm1 Jak2 ---- Ptpn11 Lepr ---- Ptpn11 Stat3 ---> leptin activated Stat3 gene targets the extracellular signal-regulated Raf/Mek/Erk signaling pathway Ptpn1 ---| Stat3 Ptpn1 ---| Jak2 Irs2 Irs1 Sh2bpsm1 Jak-Stat signaling pathway Socs3 ---| Jak2 Jak2 --+> Stat3 leptin activated Stat3 gene targets Lepr --+> phosphatidylinositol 3-kinase-Akt signaling pathway Jak2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway
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Genes in Pathway:

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leptin system pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:2302071
G Irs2 insulin receptor substrate 2 JBrowse link 16 83,824,515 83,848,569 RGD:2302071
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1625125
RGD:2302071
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:61790
RGD:2290294
RGD:2290293
RGD:1625125
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:61790
RGD:2290294
RGD:2290293
RGD:1625125
RGD:1600611
G Lepr_v1 leptin receptor, variant 1 RGD:2290293
RGD:2290294
G Lepr_v2 leptin receptor, variant 2 RGD:2290292
RGD:2290294
RGD:2290293
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:2289366
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:2289807
G Sh2b1 SH2B adaptor protein 1 JBrowse link 1 197,878,839 197,888,223 RGD:2302071
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:1625125
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:1600611
RGD:1625125
altered leptin system pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:2290473
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:61790
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:61790
RGD:1600611
G Lepr_v2 leptin receptor, variant 2 RGD:2290292

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupLeptin activated Stat3 gene targetsLeptin activated Stat3 gene targets

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the leptin system pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayStat3
aldosterone signaling pathwayIrs1 , Irs2 , Jak2
altered energy homeostasis pathwayLep , Lepr
altered Jak-Stat signaling pathwayJak2
altered leptin system pathwayLep , Lepr , Lepr_v2
angiotensin II signaling pathwayJak2
angiotensin II signaling pathway via AT1 receptorJak2
ceramide signaling pathwayStat3
chemokine mediated signaling pathwayJak2 , Stat3
chronic myeloid leukemia pathwayPtpn11
cytokine mediated signaling pathwayLep , Lepr
endothelin signaling pathwayJak2
energy homeostasis pathwayLep , Lepr
epidermal growth factor/neuregulin signaling pathwayPtpn1 , Ptpn11 , Stat3
erythropoietin signaling pathwayIrs2 , Jak2 , Ptpn11 , Socs3
fibroblast growth factor signaling pathwayPtpn11
granulocyte-macrophage colony-stimulating factor signaling pathwayJak2 , Ptpn11 , Stat3
growth hormone signaling pathwayJak2
hepatitis C virus infection pathwaySocs3 , Stat3
hypoxia inducible factor pathwayLep
influenza A virus infection pathwayJak2 , Socs3
insulin signaling pathwayIrs1 , Irs2 , Ptpn1 , Ptpn11 , Socs3
insulin-like growth factor signaling pathwayIrs1 , Irs2 , Ptpn1 , Ptpn11
Interleukin-10 signaling pathwayStat3
interleukin-12 signaling pathwayJak2 , Stat3
interleukin-2 signaling pathwayIrs1 , Irs2 , Ptpn11 , Socs3 , Stat3
interleukin-23 signaling pathwayJak2 , Socs3 , Stat3
interleukin-27 signaling pathwayJak2 , Stat3
interleukin-3 signaling pathwayJak2 , Ptpn11
interleukin-4 signaling pathwayIrs1 , Irs2 , Jak2 , Socs3
interleukin-5 signaling pathwayJak2 , Ptpn11
interleukin-6 signaling pathwayJak2 , Ptpn11 , Socs3 , Stat3
Jak-Stat signaling pathwayJak2 , Lep , Lepr , Ptpn1 , Ptpn11 , Socs3 , Stat3
Leishmania infection pathwayJak2
leptin system pathwayIrs1 , Irs2 , Jak2 , Lep , Lepr , Lepr_v1 , Lepr_v2 , Ptpn1 , Ptpn11 , Sh2b1 , Socs3 , Stat3
measles infection pathwayJak2 , Stat3
mTOR signaling pathwayIrs1
Mycobacterium tuberculosis infection pathwayJak2
N-cadherin signaling pathwayPtpn1 , Ptpn11
neurotrophic factor signaling pathwayIrs1 , Irs2 , Ptpn11 , Sh2b1
obesity disease pathwayLepr , Lepr_v2
pancreatic cancer pathwayStat3
platelet-derived growth factor signaling pathwayJak2 , Ptpn1 , Ptpn11 , Stat3
renal cell cancer pathwayPtpn11
scatter factor/hepatocyte growth factor signaling pathwayPtpn11
somatostatin signaling pathwayJak2 , Ptpn11
sphingosine 1-phosphate signaling pathwayIrs1 , Jak2
Toxoplasma gondii infection pathwayJak2 , Stat3
type 2 diabetes mellitus pathwayIrs1 , Irs2 , Socs3
type II interferon signaling pathwayJak2 , Ptpn11 , Stat3
ubiquitin/proteasome degradation pathwaySocs3
vascular endothelial growth factor signaling pathwayPtpn11
Phenotype Annotations Associated with Genes in the leptin system pathway

References Associated with the leptin system pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: