INTEGRIN MEDIATED SIGNALING PATHWAY (PW:0000286)

View Ontology Report

Description

Integrin mediated signaling involves cell-cell and cell-extracellular matrix (ECM) specific protein interactions. Integrin alpha and beta subunits form the approximately 24 known pairs of receptor heterodimer complexes. In the absence of stimuli the receptors are in a low-affinity ligand binding state - the 'bent' conformation. Structural re-arrangements triggered by agonists give rise to the 'extended', high-affinity ligand binding state. The integrin mediated signaling is bi-directional: bindi

Pathway Diagram:

Ariadne Genomics Inc. Itgb1bp1 ---- Krit1 Tln1 Itga Itga ---- Sharpin Fabp3 ---- Itga Fblim1 ---- filamins cell motility cell differentiation cell proliferation cell survival PIP2 Fblim1 ---| filamins kindlins (Fermt) Ilk Sharpin ---| Itgb Fabp3 Sharpin Fabp3 ---| Itgb Itgb Fblim1 Krit1 Itgb1bp1 ---| Itgb Itgb ---- Itgb1bp1 Itgb1bp1 filamins ---| Itgb filamins ---- Itgb Itgb ---> invasion Ptk2 RTK, others Itgb ---- Tln1 Itgb ---- Tln2 kindlins (Fermt) --+> Itgb Itgb ---- kindlins (Fermt) Itga ---> cell adhesion Itga ---> invasion invasion Ilk ---- Parvb Parva ---- Pxn Nck2 ---- RTK, others Ilk ---- Lims1 Ilk ---- Pxn Ilk ---- Parva Lims1 ---- Nck2 Ptk2 ---- RTK, others Ptk2 ---- Tln1 Ilk ---- Parvg Apbb1ip ---- Tln2 Apbb1ip ---- Tln1 Tln1 --+> Itgb Tln2 cell surface proteins Itgb ---> cell migration Itga ---> cell migration Itga ---> ECM assembly Itgb ---> ECM assembly RTK, others ---> invasion ECM assembly cell migration ECM proteins cell adhesion Itgb ---> cell adhesion Krit1 ---| Itgb1bp1 Tln2 --+> Itgb Pxn Ptk2 ---- Pxn Ilk ---- Lims2 Lims2 Lims1 Ilkap Ilkap ---| Ilk Parvb Parva Parvg Apbb1ip Nck2 Ilk ---- Itgb filamins
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Genes in Pathway:

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integrin mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein JBrowse link 17 90,098,953 90,149,192 RGD:2300340
G Fabp3 fatty acid binding protein 3 JBrowse link 5 148,528,854 148,535,597 RGD:7364738
G Fblim1 filamin binding LIM protein 1 JBrowse link 5 160,122,466 160,158,921 RGD:7349373
G Fermt1 fermitin family member 1 JBrowse link 3 125,566,744 125,607,864 RGD:7349373
G Fermt2 fermitin family member 2 JBrowse link 15 19,807,806 19,876,557 RGD:7349373
G Fermt3 fermitin family member 3 JBrowse link 1 222,254,183 222,272,775 RGD:7349373
G Flna filamin A JBrowse link X 156,460,785 156,487,245 RGD:7364738
G Flnb filamin B JBrowse link 15 18,750,152 18,883,019 RGD:7364738
G Flnc filamin C JBrowse link 4 56,710,934 56,738,779 RGD:7364738
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:633110
RGD:2300344
RGD:2302091
G Ilkap ILK associated serine/threonine phosphatase JBrowse link 9 98,514,599 98,536,586 RGD:2300344
G Itga1 integrin subunit alpha 1 JBrowse link 2 47,127,403 47,281,387 RGD:729264
RGD:5135538
G Itga10 integrin subunit alpha 10 JBrowse link 2 198,772,937 198,792,253 RGD:1358329
RGD:5135538
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,874 67,683,973 RGD:1358329
RGD:5135538
G Itga2 integrin subunit alpha 2 JBrowse link 2 46,996,904 47,097,011 RGD:1302878
RGD:5135538
G Itga2b integrin subunit alpha 2b JBrowse link 10 90,397,960 90,416,550 RGD:5135538
G Itga3 integrin subunit alpha 3 JBrowse link 10 82,855,841 82,887,755 RGD:1358329
RGD:5135538
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:1302879
RGD:5135538
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:1300196
RGD:5135538
G Itga6 integrin subunit alpha 6 JBrowse link 3 58,442,904 58,515,124 RGD:1358329
RGD:5135538
G Itga7 integrin subunit alpha 7 JBrowse link 7 3,355,079 3,383,886 RGD:70774
RGD:5135538
G Itga8 integrin subunit alpha 8 JBrowse link 17 79,321,893 79,676,927 RGD:633055
RGD:5135538
G Itga9 integrin subunit alpha 9 JBrowse link 8 127,271,029 127,576,709 RGD:1358329
G Itgad integrin subunit alpha D JBrowse link 1 199,595,968 199,623,931 RGD:1358329
RGD:5135538
G Itgae integrin subunit alpha E JBrowse link 10 59,652,324 59,711,885 RGD:633077
RGD:5135538
G Itgal integrin subunit alpha L JBrowse link 1 198,744,053 198,781,745 RGD:1358329
RGD:5135538
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:1358329
RGD:5135538
G Itgav integrin subunit alpha V JBrowse link 3 71,113,269 71,205,958 RGD:1358329
RGD:1625134
RGD:5135538
G Itgax integrin subunit alpha X JBrowse link 1 199,555,560 199,576,948 RGD:5135538
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1302874
RGD:1625134
RGD:5135538
G Itgb1bp1 integrin subunit beta 1 binding protein 1 JBrowse link 6 43,348,927 43,363,633 RGD:7349373
RGD:7364738
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:1358329
RGD:5135538
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:633129
RGD:1625134
RGD:5135538
G Itgb4 integrin subunit beta 4 JBrowse link 10 104,524,000 104,560,180 RGD:729025
RGD:5135538
G Itgb5 integrin subunit beta 5 JBrowse link 11 70,056,500 70,172,164 RGD:724441
RGD:5135538
G Itgb6 integrin beta 6 JBrowse link 3 46,652,624 46,775,362 RGD:1358329
RGD:5135538
G Itgb7 integrin subunit beta 7 JBrowse link 7 143,820,236 143,837,802 RGD:633040
RGD:5135538
G Itgb8 integrin subunit beta 8 JBrowse link 6 147,089,280 147,172,846 RGD:1358329
RGD:5135538
G Krit1 KRIT1, ankyrin repeat containing JBrowse link 4 27,438,609 27,473,150 RGD:7349373
RGD:7364738
G Lims1 LIM zinc finger domain containing 1 JBrowse link 20 27,895,981 28,004,767 RGD:2300344
G Lims2 LIM zinc finger domain containing 2 JBrowse link 18 24,707,951 24,746,159 RGD:2300344
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:2300344
G Parva parvin, alpha JBrowse link 1 177,249,302 177,408,160 RGD:2300344
G Parvb parvin, beta JBrowse link 7 125,189,827 125,275,977 RGD:2300344
G Parvg parvin, gamma JBrowse link 7 125,288,081 125,307,587 RGD:2300344
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:2300402
G Pxn paxillin JBrowse link 12 46,797,953 46,845,107 RGD:2300344
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,455 RGD:7349373
RGD:7364738
G Tln1 talin 1 JBrowse link 5 59,033,635 59,063,592 RGD:2300340
RGD:7349373
G Tln2 talin 2 JBrowse link 8 73,009,980 73,441,536 RGD:7349373
altered integrin mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:5490966
G Itga1 integrin subunit alpha 1 JBrowse link 2 47,127,403 47,281,387 RGD:1302875
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,874 67,683,973 RGD:5490966
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:1302879
RGD:5490966
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:1302875
G Itga7 integrin subunit alpha 7 JBrowse link 7 3,355,079 3,383,886 RGD:70774
G Itga8 integrin subunit alpha 8 JBrowse link 17 79,321,893 79,676,927 RGD:633055
G Itga9 integrin subunit alpha 9 JBrowse link 8 127,271,029 127,576,709 RGD:5490966
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1302874

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Groupfilaminsfilamin activators
Functional ClassItgaintegrin alpha subunit
Functional ClassItgbintegrin beta subunit
Gene Groupkindlins (Fermt)kindlin activators

Pathway Gene Annotations

Disease Annotations Associated with Genes in the integrin mediated signaling pathway
Disease TermsGene Symbols
Abortion, SpontaneousItga2 , Itgb4
Absent Radii and ThrombocytopeniaItga10
Acute Coronary SyndromeItgb3
Acute Lung InjuryItgb2
AlbuminuriaNck2
Alzheimer DiseaseFabp3
Anemia, Iron-DeficiencyItga2
Angina, UnstableItga2
Angiokeratoma Corporis Diffusum with Arteriovenous FistulasKrit1
ANTERIOR SEGMENT DYSGENESIS 7Pxn
Anti-Glomerular Basement Membrane DiseaseItga4
Aortic Aneurysm, AbdominalItgav
Arrhythmias, CardiacItga2
Arterial Occlusive DiseasesItgb3
ArteriosclerosisItga1 , Itga2 , Itga7 , Itgb3
Arthritis, ExperimentalItga4 , Itgb2 , Itgb3
Arthritis, JuvenileItga2b , Itgb5
Arthritis, RheumatoidItga6 , Ptk2
AsthmaItgb3
Atelosteogenesis Type 1Flnb
Atelosteogenesis Type 3Flnb
AtrophyFermt1
Autism Spectrum DisorderItgb3
Autistic DisorderItga4 , Itgb3
Banti's SyndromeItgb3
Behcet SyndromeItga2 , Itgal , Itgb2
Blood Platelet DisordersFermt3
Bone Diseases, DevelopmentalFlnb , Itgb1bp1
Boomerang DysplasiaFlnb
Branch Retinal Vein OcclusionItga2
Breast NeoplasmsFlna , Itga1 , Ptk2
Bronchial HyperreactivityItgb3
CalcinosisItgb1 , Itgb2
Candidiasis, InvasiveItgam
Carcinoma, Adenoid CysticItgb4
Carcinoma, HepatocellularPtk2
Carcinoma, Intraductal, NoninfiltratingPtk2
Carcinoma, Non-Small-Cell LungItgb1 , Itgb3 , Pxn
Carcinoma, Squamous CellItga5 , Itgb1 , Ptk2
Cardiac Valvular Dysplasia, X-LinkedFlna
CardiomegalyItga3
CardiomyopathiesFlnc , Ilk , Itgb1
Cardiomyopathy, DilatedIlk , Itgb1
CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 26Flnc
CARDIOMYOPATHY, FAMILIAL RESTRICTIVE, 5Flnc
Cardiomyopathy, HypertrophicIlk
Cardiomyopathy, Hypertrophic, FamilialIlk
Carotid Artery InjuriesItgb3
Carotid Artery ThrombosisItga2b , Itgb3
Carotid StenosisItgb3
Cavernous Malformations of CNS and RetinaKrit1
Cell Transformation, NeoplasticPtk2
Cerebral HemorrhageItga2b , Itgav , Itgb2 , Itgb3
ChloracneItgb2
Choroidal NeovascularizationItgav
Chronic PeriodontitisItgb2
Cleft PalateFlna , Flnb
ClubfootFlnb
Cocaine-Related DisordersIlk
ColitisItgb2
Colitis, ExperimentalItga2 , Itga4
Colonic NeoplasmsItga7
Colonic PolypsIlk
Colorectal NeoplasmsFlnc , Itgb3
Congenital Idiopathic Intestinal PseudoobstructionFlna
Constriction, PathologicItgb3
Corneal NeovascularizationItgav
Coronary Artery DiseaseItga2
Coronary DiseaseItga2 , Itgb3
Coronary RestenosisItgb2
Coronary StenosisItgav
Coronary ThrombosisItgb3
Craniofacial AbnormalitiesItgb1bp1
CraniosynostosesFlna
Death, Sudden, CardiacItgb3
DermatitisItgb2 , Sharpin
Dermatitis, Allergic ContactItgam
Diabetes MellitusItga2
Diabetes Mellitus, ExperimentalFabp3 , Itga3 , Itgb1 , Itgb3
Diabetes Mellitus, Type 1Itga2
Diabetes Mellitus, Type 2Fabp3 , Itga2
Diabetic NephropathiesItga2
Diabetic RetinopathyItga2 , Itga4 , Itgb3
Down SyndromeFabp3
Ectodermal DysplasiaItgb4
Encephalomyelitis, Autoimmune, ExperimentalItga4
Endometrial HyperplasiaPtk2
Endometrial NeoplasmsPtk2
EndometriosisItga2 , Itgb1 , Itgb8 , Ptk2
EndotoxemiaItga2b , Itgb3
EnterocolitisItgb2
EosinophiliaSharpin
Epidermolysis BullosaItgb4
Epidermolysis Bullosa SimplexItgb4
Epidermolysis Bullosa with Pyloric AtresiaItga6 , Itgb4
Epidermolysis Bullosa, JunctionalItga6 , Itgb4
Epidermolysis Bullosa, Junctional, Non-Herlitz TypeItgb4
EpilepsyFlna , Ilk
ErythemaFermt1
Filaminopathy, Autosomal DominantFlnb , Flnc
Frontometaphyseal DysplasiaFlna
GalactosemiasItgb4
Genetic Diseases, InbornItga11
Glanzmann Thrombasthenia, Autosomal DominantItga2b , Itgb3
Glaucoma, Angle-ClosureFermt2
GlioblastomaPtk2
GliosisItga1 , Itga2 , Itga4 , Itga5 , Itgb1 , Itgb3 , Itgb4
GlomerulonephritisItga3 , Itgam , Itgb1 , Itgb2 , Itgb3
Glomerulosclerosis, Focal SegmentalItgb3
Glycoprotein IA DeficiencyItga2
Graft vs Host DiseaseItga2
Graves DiseaseItgb3
Hantavirus InfectionsItgb3
Hearing Loss, ConductiveFlna
Hearing Loss, SensorineuralItga2
Hearing Loss, SuddenItga2
Heart FailureItgb1
Heart Valve DiseasesItgb2
Hemangioma, Cavernous, Central Nervous SystemKrit1
HemorrhageFermt3 , Itgb3
Hemorrhagic DisordersItgb3
Hemorrhagic Fever with Renal SyndromeItgb3
Hereditary Renal AgenesisItga8
Heterotopia, Periventricular, Ehlers-Danlos VariantFlna
Hip FracturesItgb3
HydrocephalusItgb1
HyperalgesiaItga1 , Itga2 , Itga3 , Itga5 , Itgb1
HyperglycemiaItgav
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated with Cerebral Capillary MalformationsKrit1
HypersensitivityItgb2
HypertensionFabp3 , Itgav , Ptk2
Hypertension, PulmonaryPtk2
Hypertrophy, Left VentricularPtk2
Hypertrophy, Right VentricularPtk2
IleitisItgam
Infertility, FemaleItga2
InflammationItgal
Inflammatory Bowel DiseasesItga4 , Itgal , Itgb8
Insulin ResistanceFabp3
Interstitial Lung Disease, Nephrotic Syndrome, and Epidermolysis Bullosa, CongenitalItga3
Intestinal Pseudo-ObstructionFlna
IschemiaItgav , Ptk2
Ischemic Attack, TransientIlk , Itgb3
Kidney Failure, ChronicItga8 , Itgb3
Kidney NeoplasmsItgb2
Kidney Reperfusion InjuryItgb2
Larsen SyndromeFlnb
Larsen Syndrome, Dominant TypeFlnb
LeiomyomaPtk2
Leukemia, Lymphocytic, Chronic, B-CellItga4
Leukemia, Myeloid, AcuteFermt2 , Fermt3 , Itgav , Itgb3
Leukemia, Promyelocytic, AcuteItgal , Itgam , Itgax , Itgb2
Leukocyte Adhesion Deficiency Type 1Fermt3 , Itgb2
Leukocyte Adhesion Deficiency, Type IIIFermt3
Leukocyte DisordersItgb2
Leukocyte-Adhesion Deficiency SyndromeItgb2
LeukocytosisItga4
Limb IschemiaItgav
Liver CirrhosisItgb6
Liver Cirrhosis, ExperimentalApbb1ip , Flna , Ilk , Itga2b , Itgal , Itgb1 , Itgb2 , Itgb3 , Itgb6 , Ptk2
Long QT SyndromeIlk
Lung DiseasesItgb3
Lupus Erythematosus, SystemicItgam
Lupus NephritisItgam
Malformations of Cortical Development, Group IIFlna
Mammary Neoplasms, ExperimentalIlk , Itgb3 , Ptk2
Melanoma, ExperimentalPxn
Mesangial Proliferative GlomerulonephritisItga8
Mesothelioma, MalignantIlk
Metabolic Syndrome XItgav
Mitral Valve ProlapseFlna
Molybdenum Cofactor DeficiencyItga2
Mouth NeoplasmsPtk2
Muscular DiseasesFabp3 , Itga7
Muscular DystrophiesItga7
Muscular Dystrophy, Congenital, due to Integrin Alpha-7 DeficiencyItga7
Muscular Dystrophy, Limb-Girdle, Type 2WLims2
Myelodysplastic SyndromesItgb3
Myocardial InfarctionFabp3 , Itga2 , Itga3 , Itgb3
Myocardial IschemiaItgav
Myopathy, Distal, 4Flnc
Nasal PolypsItgal
NecrosisFabp3
Neoplasm InvasivenessItga5 , Itgb1 , Ptk2 , Tln1
Neoplasm MetastasisItga6 , Itgb1 , Itgb3 , Ptk2 , Pxn
NephritisItga4 , Itgal , Itgam , Itgb2 , Ptk2
NephrosisItgb2
Nephrotic SyndromeNck2
NeuralgiaItgam
Nonarteritic Anterior Ischemic Optic NeuropathyItgb3
ObesityFabp3
Opitz-Kaveggia SyndromeFlna
OsteochondrodysplasiasFlna , Flnb
Osteogenesis ImperfectaItga3
OsteopetrosisFermt3
OsteoporosisTln1
Oto-Palato-Digital Syndrome Type 1Flna
Oto-Palato-Digital Syndrome, Type 2Flna
Otopalatodigital Spectrum DisorderFlna
Ovarian NeoplasmsFermt3 , Itga8 , Ptk2
Pancreatic NeoplasmsIlk , Itga11 , Itga4 , Itga9
PancreatitisItgb2
Periventricular Nodular HeterotopiaFlna
Phyllodes TumorFlna
Placental InsufficiencyItga2
Pleomorphic Xanthoastrocytoma Flnc , Itgb8 , Krit1
PneumoniaItga2 , Itga4 , Itgb2 , Itgb3
Pneumonia, BacterialItgb3
Poikiloderma of KindlerFermt1
Polycystic Kidney, Autosomal DominantItga8
Posttransfusion PurpuraItgb3
Pre-EclampsiaItga4
Prostatic NeoplasmsIlk , Itgad , Itgb3 , Ptk2
ProteinuriaNck2
PsoriasisItgb2
Pulmonary EmphysemaItgb6
Purpura, ThrombocytopenicItga2b , Itgb3
Purpura, Thrombocytopenic, IdiopathicItgb3
Pyloric AtresiaItgb4
Reperfusion InjuryItga2b , Itga5 , Itgb3 , Ptk2
Retinal Necrosis Syndrome, AcuteItga2
Retinal NeovascularizationItgav
Retinal Vein OcclusionItga2
Retinitis PigmentosaItga4
Salivary Gland NeoplasmsItgb4
Schizophrenia, ChildhoodItga6
Skin Diseases, VesiculobullousFermt1
Skin UlcerItgb2
Smith-Magenis SyndromeItga2b , Itga3 , Itgb3 , Itgb4
Spinal DiseasesFlnb
Spondylocarpotarsal SynostosisFlnb
Stomach NeoplasmsItga5 , Itga8
StrokeItga2 , Itga2b , Itgav , Itgb3
Substance-Related DisordersParva
TelangiectasisFermt1
Terminal Osseous DysplasiaFlna
Thoracic DiseasesIlk
ThrombastheniaItga2 , Itga2b , Itgb3
ThrombocytopeniaItga2 , Itga2b , Itgb3
Thrombocytopenia, Neonatal AlloimmuneItga2b , Itgb3
ThrombosisItga2
Thrombotic MicroangiopathiesItgb3
Thyroid DiseasesItgb5
Transplant RejectionItga4
Tuberous SclerosisFlna
UlcerItgb3
UremiaPtk2
Urinary Bladder NeoplasmsFermt2
Uterine Cervical NeoplasmsPtk2
Uveomeningoencephalitic SyndromeItgb2
Venous ThrombosisItga2 , Itgb3
von Willebrand Disease, Type 1Itga2 , Itga2b
von Willebrand Disease, Type 2Itga2 , Itga2b
Pathway Annotations Associated with Genes in the integrin mediated signaling pathway
Pathway TermsGene Symbols
abciximab pharmacodynamics pathwayItga2b , Itgb3
altered integrin mediated signaling pathwayIlk , Itga1 , Itga11 , Itga4 , Itga5 , Itga7 , Itga8 , Itga9 , Itgb1
altered Reelin signaling pathwayItga3 , Itgb1
arrhythmogenic right ventricular cardiomyopathy pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
calcium signaling pathway via the calcium-sensing receptorFlna
cell-extracellular matrix signaling pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
chemokine mediated signaling pathwayPtk2 , Pxn
dilated cardiomyopathy pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
E-cadherin signaling pathwayItgae , Itgb7
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaFabp3 , Ilk
endometrial cancer pathwayIlk
Entamoeba histolyca infection pathwayItgam , Itgb2 , Ptk2
ephrin - ephrin receptor bidirectional signaling axisItga2b , Itgb3 , Nck2 , Pxn
epidermal growth factor/neuregulin signaling pathwayNck2 , Ptk2 , Tln1
eptifibatide pharmacodynamics pathwayItga2b , Itgb3
glomerulonephritis pathwayItga8 , Itgb1
hypertrophic cardiomyopathy pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
hypoxia inducible factor pathwayItgb2
insulin signaling pathwayNck2
insulin-like growth factor signaling pathwayNck2 , Pxn
integrin mediated signaling pathwayApbb1ip , Fabp3 , Fblim1 , Fermt1 , Fermt2 , Fermt3 , Flna , Flnb , Flnc , Ilk , Ilkap , Itga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga3 , Itga4 , Itga5 , Itga6 , Itga7 , Itga8 , Itga9 , Itgad , Itgae , Itgal , Itgam , Itgav , Itgax , Itgb1 , Itgb1bp1 , Itgb2 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8 , Krit1 , Lims1 , Lims2 , Nck2 , Parva , Parvb , Parvg , Ptk2 , Pxn , Sharpin , Tln1 , Tln2
interleukin-4 signaling pathwayItgb3
Leishmania infection pathwayItga4 , Itgam , Itgb1 , Itgb2
long term potentiationPtk2
mitogen activated protein kinase signaling pathwayFlna , Flnb , Flnc
mTOR signaling pathwayPxn
Mycobacterium tuberculosis infection pathwayItgam , Itgax , Itgb2
myocardial infarction pathwayItga1 , Itga5
myocarditis pathwayItgal , Itgb2
nuclear factor kappa B signaling pathwaySharpin
pancreatic cancer pathwayIlk , Itga11 , Itga4 , Itga9
phagocytosis pathwayItga2 , Itga5 , Itgam , Itgb1 , Itgb2 , Itgb3 , Itgb5
Plasmodium infection pathwayItgal , Itgb2
platelet aggregation pathwayItgb3
platelet-derived growth factor signaling pathwayItgav , Itgb3 , Nck2
Reelin signaling pathwayItga3 , Itgb1 , Nck2
rheumatoid arthritis disease pathwayItgal , Itgb2
Rho/Rac/Cdc42 mediated signaling pathwayFlna
small cell lung cancer pathwayItga2 , Itga2b , Itga6 , Itgb1 , Ptk2
sphingosine 1-phosphate signaling pathwayItgav , Itgb3
Staphylococcus aureus infection pathwayItgal , Itgam , Itgb2
syndecan signaling pathwayItga2 , Itga5 , Itgb1
T cell receptor signaling pathwayNck2
tirofiban pharmacodynamics pathwayItga2b , Itgb3
Toxoplasma gondii infection pathwayItga6 , Itgb1
tumor necrosis factor mediated signaling pathwaySharpin
vascular endothelial growth factor signaling pathwayItgav , Itgb3 , Nck2 , Ptk2 , Pxn
Wnt signaling, non-canonical pathwayFlna
Phenotype Annotations Associated with Genes in the integrin mediated signaling pathway

References Associated with the integrin mediated signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: