AUTOPHAGY PATHWAY (PW:0000278)

View Ontology Report

Description

Autophagy, the catabolic pathway of cytoplasmic degradation is essential for cellular and tissue homeostasis and it can act as a source of nutrients under starvation or stress conditions. Autophagy encompasses macro and microautophagy, conserved across species, and the chaperone-mediated autophagy (CMA) which appears to be confined to mammalian cells. Macroautophagy (autophagy hereafter) is the pathway described here and shown in the diagram. It involves the sequestration of damaged organelles a

Pathway Diagram:

Ariadne Genomics Inc. Lamp members SNARE, ESCRT, Rabs Atg4 members Atg9 members LC3 conjugation system Atg12 conjugation system Pik3c3 Pik3r4 Atg14 Rb1cc1 Ulk1 mTOR signaling pathway PtdIns3P Atg4 members ---> LC3 conjugation system starvation ---| mTOR signaling pathway nutrient-rich --+> mTOR signaling pathway starvation nutrient-rich Becn1 ---- Uvrag Ulk2 --+> Atg13 Ulk1 --+> Rb1cc1 Becn1 class III PI3K complex Becn1 ---- Rubicon mTOR signaling pathway ---| Ulk1 mTOR signaling pathway ---| Ulk2 Rubicon Uvrag Atg12 conjugation system ---> LC3 conjugation system Acp2 ---> degradation Acp2 degradation Lamp members ---> degradation Ulk2 Atg13 Atg13 ---- Rb1cc1 Pik3c3 ---> PtdIns3P PE Ulk/Atg13/Atg17 complex class III PI3K complex ---> Atg12 conjugation system
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Genes in Pathway:

show annotations for term's descendants       view all columns
autophagy pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acp2 acid phosphatase 2, lysosomal JBrowse link 3 80,020,346 80,030,365 RGD:4892631
G Atg10 autophagy related 10 JBrowse link 2 19,853,546 20,152,918 RGD:1643329
RGD:4889529
G Atg12 autophagy related 12 JBrowse link 18 40,721,799 40,732,143 RGD:1643329
RGD:2301217
RGD:4889529
RGD:6907045
G Atg13 autophagy related 13 JBrowse link 3 80,580,549 80,614,554 RGD:4889529
G Atg14 autophagy related 14 JBrowse link 15 24,343,418 24,374,776 RGD:4889529
G Atg16l1 autophagy related 16-like 1 JBrowse link 9 94,879,876 94,915,231 RGD:1643329
RGD:4889529
G Atg16l2 autophagy related 16-like 2 JBrowse link 1 166,401,271 166,415,078 RGD:1643329
RGD:4889529
G Atg3 autophagy related 3 JBrowse link 11 60,585,192 60,613,706 RGD:1643237
RGD:1643329
RGD:4889529
RGD:6907045
G Atg4a autophagy related 4A, cysteine peptidase JBrowse link X 112,328,907 112,403,157 RGD:1643329
G Atg4b autophagy related 4B, cysteine peptidase JBrowse link 9 100,888,457 100,920,123 RGD:1643329
RGD:6907045
G Atg4c autophagy related 4C, cysteine peptidase JBrowse link 5 117,861,517 117,932,116 RGD:1643329
RGD:6907045
G Atg4d autophagy related 4D, cysteine peptidase JBrowse link 8 22,291,445 22,301,331 RGD:1643329
RGD:6907045
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:2301217
RGD:4889529
RGD:6907045
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:1643198
RGD:1643329
RGD:4889529
RGD:6907045
G Atg9a autophagy related 9A JBrowse link 9 82,382,800 82,393,429 RGD:4889529
G Atg9b autophagy related 9B JBrowse link 4 7,314,369 7,322,095 RGD:4889529
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:1643194
RGD:1643329
RGD:4889529
RGD:6907045
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:4892619
G Chmp3 charged multivesicular body protein 3 JBrowse link 4 99,449,213 99,496,156 RGD:4892619
G Gabarap GABA type A receptor-associated protein JBrowse link 10 56,601,288 56,604,223 RGD:1643329
RGD:4890444
RGD:6907045
G Gabarapl1 GABA type A receptor associated protein like 1 JBrowse link 4 163,293,724 163,302,866 RGD:4890444
RGD:6907045
G Gabarapl2 GABA type A receptor associated protein like 2 JBrowse link 19 44,164,935 44,175,771 RGD:1643329
RGD:4890444
RGD:6907045
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate JBrowse link 10 109,638,944 109,657,460 RGD:4892619
G Ifna1 interferon, alpha 1 JBrowse link 5 106,951,822 106,952,908 RGD:6907045
G Ifna11 interferon alpha family, gene 11 JBrowse link 5 107,504,741 107,505,783 RGD:6907045
G Ifna2 interferon alpha 2 JBrowse link 5 107,416,117 107,416,695 RGD:6907045
G Ifna4 interferon, alpha 4 JBrowse link 5 106,922,563 106,923,132 RGD:6907045
G Ifna5 interferon, alpha 5 JBrowse link 5 107,039,347 107,039,925 RGD:6907045
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6907045
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:6907045
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6907045
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:4892310
RGD:4892631
G Lamp2 lysosomal-associated membrane protein 2 JBrowse link X 124,722,628 124,766,079 RGD:4892310
G LOC100911527 interferon alpha-12-like JBrowse link 5 87,328,395 87,328,946 RGD:6907045
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:1643198
RGD:1643329
RGD:4890444
G Map1lc3b microtubule-associated protein 1 light chain 3 beta JBrowse link 19 53,635,449 53,643,970 RGD:1643329
RGD:4890444
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 JBrowse link 18 22,964,121 23,047,896 RGD:4889529
RGD:6907045
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 JBrowse link 8 114,300,248 114,350,686 RGD:4889529
RGD:6907045
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6907045
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:6907045
G Rab11a RAB11a, member RAS oncogene family JBrowse link 8 70,192,975 70,215,719 RGD:4892310
G Rab33b RAB33B, member RAS oncogene family JBrowse link 2 140,541,619 140,552,220 RGD:4892310
G Rab5a RAB5A, member RAS oncogene family JBrowse link 9 5,910 6,065 RGD:4892310
G Rab7a RAB7A, member RAS oncogene family JBrowse link 4 119,910,461 119,963,065 RGD:4892310
G Rb1cc1 RB1-inducible coiled-coil 1 JBrowse link 5 13,033,918 13,097,369 RGD:4889529
G Rubcn RUN and cysteine rich domain containing beclin 1 interacting protein JBrowse link 11 71,150,506 71,199,254 RGD:4889529
G Snf8 SNF8, ESCRT-II complex subunit JBrowse link 10 83,856,331 83,868,621 RGD:4892619
G Tsg101 tumor susceptibility 101 JBrowse link 1 102,941,151 102,971,017 RGD:4892619
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:1643329
RGD:4889529
RGD:6907045
G Ulk2 unc-51 like autophagy activating kinase 2 JBrowse link 10 48,050,079 48,129,377 RGD:4889529
RGD:6907045
G Ulk3 unc-51 like kinase 3 JBrowse link 8 62,368,548 62,375,229 RGD:6907045
G Uvrag UV radiation resistance associated JBrowse link 1 163,844,804 164,101,568 RGD:4889529
G Vamp3 vesicle-associated membrane protein 3 JBrowse link 5 168,126,157 168,136,628 RGD:4892310
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:4892310
G Vps4a vacuolar protein sorting 4 homolog A JBrowse link 19 39,230,050 39,243,298 RGD:4892619

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupAtg4 membersmembers of Atg4 proteases that prime Lc3/Atg8
Small MoleculePEphosphatidylethanolamine
Small MoleculePtdIns3Pphosphatidylinositol 3-phosphate
Gene GroupAtg9 membersthe transmembrane Atg9 proteins

Pathway Gene Annotations

Disease Annotations Associated with Genes in the autophagy pathway
Disease TermsGene Symbols
16Q24.3 Microdeletion SyndromeMap1lc3b
Acid Phosphatase DeficiencyAcp2
Acquired Immunodeficiency SyndromeIfng
Acute Kidney InjuryIns2
Acute Lung InjuryIfng , Prkaa1
Adenocarcinoma of EsophagusBecn1
AdenomaIns2
AdrenoleukodystrophyIfng
AlbuminuriaIns2
Alcoholic IntoxicationIfng
Alzheimer DiseaseBecn1 , Ins1 , Ins2
Amyotrophic Lateral SclerosisAtg5 , Becn1 , Chmp2b , Map1lc3a
Amyotrophic Lateral Sclerosis, Chmp2B-RelatedChmp2b
AnemiaAtg5 , Atg7
Anemia, AplasticIfng
AppendicitisIfng
Arthritis, ExperimentalIfng
Arthritis, InfectiousIfng
Arthritis, RheumatoidIfng
AsthmaIfng
Ataxia TelangiectasiaIfng
AtherosclerosisIfng
Autistic DisorderIfng
Autoimmune DiseasesIfng
Barrett EsophagusBecn1
Behcet SyndromeIfng
Bipolar DisorderIns2
Brain DiseasesIfng
Brain InfarctionBecn1
Brain InjuriesAtg12 , Becn1 , Map1lc3a
Brain IschemiaBecn1
Breast AdenocarcinomaRb1cc1
Breast Cancer, FamilialTsg101
Breast NeoplasmsIfng , Prkaa1 , Rb1cc1 , Tsg101
Bronchial HyperreactivityIfng
Bronchiolitis ObliteransIfng
BronchitisIfng
BurnsBecn1 , Map1lc3a
Carcinoma, Pancreatic DuctalIns2
Carcinoma, Squamous Cell of Head and NeckVamp7
CardiomegalyAtg16l1 , Atg5 , Becn1 , Map1lc3a , Prkaa2
CardiomyopathiesLamp2 , Prkaa2
Cardiomyopathy, DilatedLamp2
Cardiomyopathy, HypertrophicBecn1 , Ins2 , Lamp2 , Map1lc3a
Cardiomyopathy, Hypertrophic, FamilialLamp2
CataractIfng
Cerebral HemorrhageBecn1 , Map1lc3a
Chagas DiseaseIfng
Charcot-Marie-Tooth DiseaseRab7a
Charcot-Marie-Tooth Disease, Type 2BRab7a
ChillsIfng
Chlamydia InfectionsIfng
ChloracneRab11a
Chmp2b-Related Frontotemporal DementiaChmp2b
ChoroiditisIfng
Chronic Intermittent HypoxiaBecn1 , Map1lc3a
ColitisIfng
Colitis, ExperimentalIfng
Colonic NeoplasmsBecn1 , Ifng , Prkaa1
Conjunctivitis, AllergicIfng
Corneal PerforationIfng
Crohn DiseaseAtg16l1 , Ifng
Depressive DisorderBecn1 , Map1lc3a
Dermatitis, Allergic ContactIfng
Dermatitis, AtopicIfng
DermatomyositisIfng
Developmental DisabilitiesRubcn
Diabetes ComplicationsPrkaa1
Diabetes MellitusIns1 , Ins2
Diabetes Mellitus, ExperimentalAtg7 , Becn1 , Ifng
Diabetes Mellitus, Insulin-Dependent, 2Ins1 , Ins2
Diabetes Mellitus, Permanent NeonatalIns1 , Ins2
Diabetes Mellitus, Type 1Ifng , Ins2
Diabetes Mellitus, Type 2Becn1 , Ifng , Ins1 , Ins2 , Map1lc3a , Prkaa1 , Prkaa2
Diabetes, GestationalIns2
Diabetic CardiomyopathiesIns2
Diabetic KetoacidosisIns2
Diabetic NephropathiesBecn1 , Ifng , Ins2
Diabetic NeuropathiesBecn1 , Ifng
Diabetic RetinopathyIns2
Disease Models, AnimalIfng
Drug-Induced Liver InjuryAtg5 , Ifng , Map1lc3b
Dry Eye SyndromesIfng
DystoniaIns2
EdemaIns2
Encephalitis, ViralBecn1
Encephalomyelitis, Acute DisseminatedIfng
Encephalomyelitis, Autoimmune, ExperimentalIfng , Prkaa1
Endometrial NeoplasmsTsg101
EndophthalmitisIfng
EndotoxemiaIfng , Prkaa1
EntamoebiasisIfng
Enterocolitis, NecrotizingBecn1
EpilepsyBecn1
Experimental SeizuresBecn1
Eyelid DiseasesIfng
Fanconi AnemiaIfng
Fatty LiverIns2 , Prkaa1
FeverIfng
Frontotemporal DementiaChmp2b
Frontotemporal Lobar DegenerationChmp2b
Giant Cell ArteritisIfng
GlaucomaBecn1
GlioblastomaBecn1 , Map1lc3a
GliomaAtg7 , Ifng
GlomerulonephritisIfng
Glucose IntoleranceIns2 , Prkaa1 , Prkaa2
Glucosephosphate Dehydrogenase DeficiencyIfng
Glycogen Storage Disease Type IIbLamp2
Graft vs Host DiseaseIfng
Granulomatous Disease, ChronicIfng
Graves DiseaseIfng
Graves OphthalmopathyIfng
Growth Restriction, Severe, with Distinctive FaciesIns1
Hashimoto DiseaseIfng
Head Injuries, ClosedBecn1
Hearing Loss, SensorineuralIfng
Heart ArrestIfng , Ins2
Heart FailureBecn1 , Ifng , Ins2
Heat StrokeBecn1
Hemophilia AIfng
Hemorrhagic Fever with Renal SyndromeIfng
HepatitisIfng , Ins2
Hepatitis BIfng
Hepatitis CIfng
Hepatitis, AutoimmuneIfng
HepatomegalyAtg5
Herpes GenitalisIfng
HIV InfectionsIfng
Huntington DiseasePrkaa1
HyperalgesiaBecn1 , Map1lc3a
HyperglycemiaIns2
HyperinsulinismIns2
HyperkalemiaIns2
HyperproinsulinemiaIns1 , Ins2
HypersensitivityIfng
Hypersensitivity, DelayedIfng
HypertensionAtg7 , Becn1 , Ins2 , Map1lc3a
HypertriglyceridemiaIns2
HyperuricemiaIns2
HypoglycemiaIns2
HypokalemiaIns2
HyponatremiaIfng
HypotensionIfng , Ins2
Hypoxia-Ischemia, BrainBecn1 , Map1lc3a
IgG DeficiencyIfng
Immune Complex DiseasesIfng
Infarction, Middle Cerebral ArteryBecn1
InflammationIfng
Inflammatory Bowel Disease 10Atg16l1
Inflammatory Bowel DiseasesAtg16l1
Insulin ResistanceIns2 , Prkaa1 , Prkaa2
InsulinomaIns2
Intellectual DisabilityRubcn
Intervertebral Disc DegenerationBecn1 , Map1lc3a
IschemiaAtg5 , Becn1 , Map1lc3a
Ischemic Attack, TransientBecn1 , Map1lc3a
Job SyndromeIfng
Kaposi Varicelliform EruptionIfng
Keratitis, HerpeticIfng
Kidney CalculiIfng
Kidney Diseases, CysticIns2
Kidney Failure, ChronicBecn1
Kidney Reperfusion InjuryBecn1 , Map1lc3a
Legionnaires' DiseaseIfng
LeishmaniasisIfng
Leishmaniasis, CutaneousIfng
Leishmaniasis, MucocutaneousIfng
Leishmaniasis, VisceralIfng
LethargyAtg5 , Atg7
Leukemia, Lymphocytic, Chronic, B-CellIfng
Leukemia, MyeloidIfng
Leukemia, Promyelocytic, AcuteIfng
Leukemia-Lymphoma, Adult T-CellIfng
Lewy Body DiseaseBecn1 , Ins2
Lichen PlanusIfng
Liver CirrhosisBecn1 , Ifng , Map1lc3a
Liver Cirrhosis, ExperimentalIfng , Ins2 , Map1lc3a
Liver Failure, AcuteIns1 , Ins2
Lung NeoplasmsBecn1 , Ifng
Lupus Erythematosus, SystemicIfng
Lupus NephritisIfng
LymphopeniaAtg5 , Atg7
Lymphoproliferative DisordersIfng
Machado-Joseph DiseaseBecn1
Manganese PoisoningIfng
Maturity-Onset Diabetes of the YoungIns1 , Ins2
Maturity-Onset Diabetes of the Young, Type 10Ins1 , Ins2
MelanomaIfng
Memory DisordersIns2
MesotheliomaIfng
Mesothelioma, MalignantIfng , Ulk2
Metabolic DiseasesIns2
Metabolic Syndrome XIns2
Micronuclei, Chromosome-DefectiveIns2
Mixed Connective Tissue DiseaseIfng
MPTP PoisoningIns2
MucositisUlk1
Multiple SclerosisIfng
Muscle HypotoniaRubcn
Muscular DiseasesIns2
Mycobacterium InfectionsIfng
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TOIfng
Myocardial InfarctionAtg7 , Becn1 , Lamp2 , Map1lc3a
Myocardial IschemiaMap1lc3b , Rab5a , Rab7a
Myocardial Reperfusion InjuryBecn1 , Map1lc3a
Nasal PolypsIfng
NauseaIfng
NecrosisAtg5 , Atg7 , Ifng
NeointimaBecn1
NeoplasmsIfng
Neoplasms, ExperimentalIfng
NephritisIfng
Nerve DegenerationBecn1 , Ifng , Map1lc3a
Neural Tube DefectsIfng , Ins2
Neurocognitive DisordersIns2
Neurodegenerative DiseasesAtg7
ObesityIfng , Ins2
Optic Neuropathy, IschemicBecn1
Oral Submucous FibrosisIfng
OsteoarthritisBecn1 , Ins2
Osteoarthritis, ExperimentalBecn1 , Map1lc3a , Ulk1
Otitis MediaIfng
Otitis Media with EffusionIfng
Otitis Media, SuppurativeIfng
Ovarian NeoplasmsTsg101
Pancreatic NeoplasmsIfng , Ins2
PancreatitisIns2
Pancreatitis, Acute NecrotizingBecn1
Pancreatitis, ChronicIfng
Pancreatitis, Experimental, Acute Becn1 , Lamp2 , Map1lc3a
Panic DisorderIns2
PanuveitisIfng
Papillomavirus InfectionsVamp7
ParalysisIns2
ParaplegiaAtg7 , Becn1
ParesthesiaIns2
Parkinson DiseaseIns2
Parkinsonian DisordersBecn1
PeritonitisBecn1 , Ifng
Pituitary Hormone Deficiency, Combined, 2Chmp2b
Pleural DiseasesIfng
PneumoniaIfng
Pneumonia, MycoplasmaIfng
Polychondritis, RelapsingIfng
Polycystic Kidney DiseasesBecn1
Polycystic Ovary SyndromeIns2
PolymyositisIfng
Precursor Cell Lymphoblastic Leukemia-LymphomaIfng
Prostatic NeoplasmsAtg13 , Ins2 , Tsg101 , Ulk2 , Uvrag
ProteinuriaIfng
PulpitisIfng
Radiation Injuries, ExperimentalIfng
Renal FibrosisIfng
Renal InsufficiencyIfng , Ins2
Reperfusion InjuryBecn1 , Ifng
Respiratory Syncytial Virus InfectionsIfng
Respiratory Tract DiseasesIfng
Retinal DetachmentMap1lc3a
Retinal Necrosis Syndrome, AcuteIfng
RhabdomyolysisIns2
Rhinitis, AllergicIfng
Salmonella Infections, AnimalIfng
SarcomaIfng
Sarcoma, ExperimentalIfng
SchizophreniaBecn1 , Rb1cc1
Scleroderma, SystemicIfng
Segawa Syndrome, Autosomal RecessiveIns1 , Ins2
SeizuresAcp2 , Ifng , Ins2
SepsisIfng
Shock, HemorrhagicIfng
Silver-Russell SyndromeIns1
Sjogren's SyndromeIfng
Smith-Magenis SyndromeBecn1 , Hgs , Snf8 , Ulk2
Smith-McCort DysplasiaRab33b
Smith-McCort Dysplasia 2Rab33b
Spinal Cord InjuriesAtg5 , Atg7 , Becn1 , Map1lc3a , Ulk1
Spinal Cord Reperfusion InjuryBecn1
Spinocerebellar Ataxia, Autosomal Recessive 15Rubcn
Squamous Cell Carcinoma of the TongueIfng
Status AsthmaticusIfng
Status EpilepticusBecn1 , Lamp2
Stevens-Johnson SyndromeIfng
Stomach NeoplasmsPrkaa1
StrokePrkaa2
Subarachnoid HemorrhageBecn1
TachycardiaIns2
Telomeric 22q13 Monosomy SyndromeIns2
Temporomandibular Joint DisordersBecn1 , Map1lc3a
Thyroiditis, AutoimmuneIfng
Thyroiditis, ChronicIfng
Transplant RejectionIfng
TrichuriasisIfng
Trifascicular BlockLamp2
Tuberous SclerosisIfng
Tuberous Sclerosis 2Ifng
Ureteral ObstructionBecn1 , Ifng
Urinary Bladder DiseasesIns2
Urinary Bladder NeoplasmsIfng
Uterine Cervical NeoplasmsTsg101
UveitisIfng
Uveitis, AnteriorIfng
Uveomeningoencephalitic SyndromeIfng
Uveoretinitis, Autoimmune, ExperimentalIfng
Ventricular Dysfunction, LeftIns2
Ventricular FibrillationIns2
Ventricular Outflow ObstructionIns2
Vesico-Ureteral RefluxIfng
VitiligoIfng
VomitingIfng
Weight LossAtg5 , Atg7 , Ins2
Pathway Annotations Associated with Genes in the autophagy pathway
Pathway TermsGene Symbols
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayPrkaa1 , Prkaa2
aldosterone signaling pathwayIns1 , Ins2
allograft rejection pathwayIfng
altered insulin signaling pathwayIns2
amyotrophic lateral sclerosis disease pathwayRab5a
antigen processing and presentation pathwayIfng
autoimmune thyroid disease pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , LOC100911527
autophagy pathwayAcp2 , Atg10 , Atg12 , Atg13 , Atg14 , Atg16l1 , Atg16l2 , Atg3 , Atg4a , Atg4b , Atg4c , Atg4d , Atg5 , Atg7 , Atg9a , Atg9b , Becn1 , Chmp2b , Chmp3 , Gabarap , Gabarapl1 , Gabarapl2 , Hgs , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , Ins1 , Ins2 , Lamp1 , Lamp2 , LOC100911527 , Map1lc3a , Map1lc3b , Pik3c3 , Pik3r4 , Prkaa1 , Prkaa2 , Rab11a , Rab33b , Rab5a , Rab7a , Rb1cc1 , Rubcn , Snf8 , Tsg101 , Ulk1 , Ulk2 , Ulk3 , Uvrag , Vamp3 , Vamp7 , Vps4a
chaperone mediated autophagy pathwayLamp2
cytokine mediated signaling pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , LOC100911527
eicosanoid signaling pathwayRab11a
endocytosis pathwayChmp2b , Hgs , Rab11a , Rab5a , Rab7a , Snf8 , Tsg101 , Vps4a
Entamoeba histolyca infection pathwayIfng , Rab5a , Rab7a
forkhead class A signaling pathwayIns2
gliclazide pharmacodynamics pathwayIns2
glyburide pharmacodynamics pathwayIns2
graft-versus-host disease pathwayIfng
hepatitis C virus infection pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , LOC100911527
hypertrophic cardiomyopathy pathwayPrkaa1 , Prkaa2
influenza A virus infection pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , LOC100911527
inositol metabolic pathwayBecn1 , Pik3c3 , Pik3r4
inositol phosphate metabolic pathwayPik3c3
insulin responsive facilitative sugar transporter mediated glucose transport pathwayIns2 , Rab11a , Rab5a
insulin signaling pathwayIns1 , Ins2 , Prkaa1 , Prkaa2
interleukin-12 signaling pathwayIfng , Rab7a
interleukin-2 signaling pathwayIfng
interleukin-23 signaling pathwayIfng
interleukin-27 signaling pathwayIfng
Jak-Stat signaling pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , LOC100911527
Leishmania infection pathwayIfng
maturity onset diabetes of the young pathwayIns1 , Ins2
measles infection pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , LOC100911527
mitochondrial autophagy pathwayAtg7 , Becn1 , Ulk1
mTOR signaling pathwayAtg13 , Ins1 , Ins2 , Prkaa1 , Prkaa2 , Rb1cc1 , Ulk1 , Ulk2 , Ulk3
Mycobacterium tuberculosis infection pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , Lamp1 , Lamp2 , LOC100911527 , Pik3c3 , Rab5a , Rab7a
Notch signaling pathwayRab11a
phagocytosis pathwayHgs , Lamp1 , Lamp2 , Pik3c3 , Rab5a , Rab7a , Vamp3
phosphatidylinositol 3-kinase signaling pathwayPik3c3
phosphoinositide metabolic pathwayBecn1 , Pik3c3 , Pik3r4
Plasmodium infection pathwayIfng
platelet-derived growth factor signaling pathwayIfng
potassium channel inhibitors pharmacodynamics pathwayIns2
prostate cancer pathwayIns1 , Ins2
Rab family mediated signaling pathwayRab11a , Rab5a
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayAtg12 , Atg5 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , LOC100911527
rheumatoid arthritis disease pathwayIfng
riboflavin metabolic pathwayAcp2
systemic lupus erythematosus pathwayIfng
T cell receptor signaling pathwayIfng
Toll-like receptor signaling pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , LOC100911527
Toxoplasma gondii infection pathwayIfng
transforming growth factor-beta superfamily mediated signaling pathwayIfng
Trypanosoma brucei infection pathwayIfng
Trypanosoma cruzi infection pathwayIfng
type 1 diabetes mellitus pathwayIfng , Ins1 , Ins2
type 2 diabetes mellitus pathwayIns1 , Ins2
type II interferon signaling pathwayIfng
ubiquitin/proteasome degradation pathwayIfng
vascular endothelial growth factor signaling pathwayHgs , Prkaa1 , Prkaa2
vasopressin signaling pathwayRab11a
vasopressin signaling pathway via receptor type 2Rab11a , Rab5a

References Associated with the autophagy pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: