ANGIOTENSIN II SIGNALING PATHWAY (PW:0000244)

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Description

Agiotensin II (AgtII), the product of Ace action in the renin-angiotensin system, is probably the most potent of the biologically active peptides the pathway generates. The system, originally viewed as solely endocrine, is now regarded as an endocrine, paracrine and autocrine one, producing an array of diverse and many times opposing actions via both the 'classical' or circulatory and the local or 'tissue' routes. Overall AgtII elicits distinct responses through signaling via receptor type 1 and

Pathway Diagram:

Ariadne Genomics Inc. Agtr1b ---> Agtr1, G protein/ligand independent signaling protein kinase C (PKC) signaling pathway AgtII renin-angiotensin system signaling pathway Agtr1a ---> Agtr1, G protein/ligand independent signaling fluid homeostasis hormone release Agtr2 ---> Agtr2, G protein/ligand independent signaling vasoconstriction antiproliferation vasodilation Agtr2, G protein/ligand independent signaling angiotensin II signaling pathway via AT2 receptor angiotensin II signaling pathway via AT1 receptor AgtII ---> hormone release AgtII ---> fluid homeostasis AgtII ---> antiproliferation AgtII ---> vasoconstriction AgtII ---- Agtr2 AgtII ---- Agtr1b Agtr2 Agtr1a Agtr1b Agt Agt ---> AgtII Agtr1, G protein/ligand independent signaling G protein mediated signaling pathway via Galphai family G protein mediated signaling pathway via Galphaq family AgtII ---- Agtr1a AgtII ---> vasodilation
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Genes in Pathway:

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angiotensin II signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1581742
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1579760
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:629553
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1566502
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:1582323
G Cma1 chymase 1 JBrowse link 15 34,601,037 34,603,819 RGD:1581745
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1600094
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:1580992
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:1581775
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:1642674
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1581825
RGD:2316188
RGD:5133683
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1581825
G Agtrap angiotensin II receptor-associated protein JBrowse link 5 164,888,069 164,898,387 RGD:2314353
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 JBrowse link 1 166,459,062 166,525,200 RGD:2316188
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5133417
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5133417
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:1581847
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:1581847
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:5133417
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:5133417
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:5133417
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:5133417
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:5133683
RGD:6478796
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:5133418
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:6478796
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582434
RGD:1582435
RGD:7401256
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1581825
RGD:7401256
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 JBrowse link 5 152,447,348 152,458,005 RGD:5133679
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:5133675
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:5133679
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:7401256
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:7401256
G Mtus1 microtubule associated tumor suppressor 1 JBrowse link 16 54,240,892 54,386,131 RGD:5133679
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:5133675
G Slc9a6 solute carrier family 9 member A6 JBrowse link X 158,979,081 159,045,019 RGD:5133679
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:5133679
G Zbtb16 zinc finger and BTB domain containing 16 JBrowse link 8 52,980,226 53,146,765 RGD:5133679

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ProteinAgtIIangiotensin II generated from Agt via the renin-angiotensin cascade pathway

Pathway Gene Annotations

Disease Annotations Associated with Genes in the angiotensin II signaling pathway
Disease TermsGene Symbols
Abortion, SpontaneousAgtr1a , Jak2
Acute Kidney InjuryAce
Acute Lung InjuryCcl2
AdenocarcinomaAce
Aggressive PeriodontitisCcl2
AIDS-Associated NephropathyAgtr1a , Agtr2
AlbuminuriaAce , Agt
AlkalosisAgt
Allanson Pantzar McLeod SyndromeAce , Agt , Agtr1a
Alveolitis, Extrinsic AllergicAce
Alzheimer DiseaseAce , Agt , Agtr1a , Jak2
AnaphylaxisAgt , Cma1
AnemiaAce , Agt , Ccl2 , Jak2
Aneurysm, DissectingAgt
Angina, UnstableAce , Agt , Agtr1a
Angiotensin I-Converting Enzyme, Benign Serum IncreaseAce
AnoxiaCcl2
Anti-Glomerular Basement Membrane DiseaseAgt , Agtr1a , Ccl2
AnuriaAgt
Aortic AneurysmAgt
Aortic Aneurysm, AbdominalAce , Agt , Agtr1a , Ccl2
Aortic CalcificationAgt
Arrhythmias, CardiacAce , Agt , Agtr1a
ArteriosclerosisCcl2
Arthritis, ExperimentalAce , Ccl2 , Jak2
Arthritis, JuvenileOlr1
Arthritis, RheumatoidCcl2 , Jak2
AsthmaAce , Agtr1a , Agtr2 , Ccl2 , Cma1
AtherosclerosisAgt , Ccl2
Atrial FibrillationAce , Agt , Agtr1a
Autistic DisorderAce , Ccl2
BacteremiaCcl2
Behcet SyndromeAce , Ccl2
BerylliosisAce
Bipolar DisorderAce , Agt , Ccl2
BradycardiaAgt
Brain InjuriesCcl2 , Jak2
Brain IschemiaAce , Ccl2
Breast NeoplasmsAce , Agt , Agtr1a , Pdpk1
Bronchial HyperreactivityCcl2
Bronchiolitis ObliteransAce , Ccl2
Budd-Chiari SyndromeJak2
CalcinosisCcl2 , Jak2
Carcinoma in SituAce
Carcinoma, HepatocellularAce
Carcinoma, LobularAgtr2
Carcinoma, Pancreatic DuctalAce , Agtr1a
Carcinoma, Renal CellAgtr1a , Agtr2
Carcinoma, Squamous CellCcl2
CardiomegalyAce , Agt , Agtr1a , Agtr1b , Cma1
CardiomyopathiesAgt , Ccl2 , Olr1
Cardiomyopathy, AlcoholicAce , Agt
Cardiomyopathy, DilatedAce , Agt , Agtr1a , Agtr2
Cardiomyopathy, HypertrophicAce , Agt , Cma1
Cardiovascular AbnormalitiesAgt
Cardiovascular DiseasesAce , Agt , Ccl2
Carotid Artery DiseasesAce , Agt , Agtr1a , Ccl2
Carotid Artery InjuriesAgtr1a , Ccl2
Carrington SyndromeCcl2
CatalepsyAgt
Cerebral Amyloid AngiopathyOlr1
Cerebral HemorrhageAce
Cerebral InfarctionAce
Cerebrovascular DisordersAgt , Agtr1a
Chagas DiseaseCcl2
Chemotherapy-Induced Febrile NeutropeniaAce
Choroidal NeovascularizationCcl2
Chronic Intermittent HypoxiaAce , Agt
Chronic PeriodontitisCcl2
Cognition DisordersAgt
ColitisCcl2
Colonic NeoplasmsCcl2
Conjunctivitis, AllergicCcl2
ContusionsCcl2
Corneal NeovascularizationAgt , Agtr1a
Coronary Artery DiseaseAce , Agt , Agtr1a , Ccl2 , Olr1
Coronary Artery Disease, Development of, in HIVCcl2
Coronary DiseaseAce , Agtr1a
Coronary RestenosisAce
Coronavirus InfectionsAce
CoughAce
Crohn DiseaseAgt , Ccl2 , Jak2
CryptococcosisCcl2
Cystic FibrosisCcl2
Death, SuddenAce , Agt
Dermatitis, AtopicCma1
Dermatitis, ContactCcl2
Diabetes Mellitus, ExperimentalAce , Agt , Agtr2 , Ccl2 , Cma1
Diabetes Mellitus, Type 1Ace , Ccl2
Diabetes Mellitus, Type 2Ace , Agt , Agtr2 , Ccl2
Diabetes, GestationalCcl2
Diabetic AngiopathiesCcl2
Diabetic CardiomyopathiesAce , Agtr2
Diabetic NephropathiesAce , Agt , Agtr1a , Agtr2 , Ccl2 , Jak2
Diabetic RetinopathyAce , Agt , Agtr1a , Ccl2
Drug HypersensitivityAce
Drug OverdoseAgt
Drug-Induced Liver InjuryCcl2
Ductus Arteriosus, PatentAgtr1a
Encephalomyelitis, Autoimmune, ExperimentalCcl2 , Jak2
Endometrial NeoplasmsCcl2
EndometriosisCcl2
Endomyocardial FibrosisAce , Agt , Ccl2
EndotoxemiaAce , Agtr2 , Ccl2
Endotoxin-Induced UveitisCcl2
Epilepsy, Temporal LobeAgt
Erectile DysfunctionAgt
Erythrocytosis, Familial, 1Jak2
Erythrocytosis, Familial, 2Jak2
Experimental Autoimmune Encephalomyelitis, Chronic RelapsingCcl2
Experimental Autoimmune OrchitisCcl2
Eye NeoplasmsCcl2
Familial Cerebral Cavernous MalformationAce
Fatty LiverCcl2 , Jak2
Febrile NeutropeniaCcl2
Fetal DeathAce
Fetal Growth RetardationAgt , Agtr1a , Agtr2
FibrosisAgt , Agtr1a , Agtr2
Gallbladder NeoplasmsAce
GastritisCcl2
Gaucher DiseaseAce
Genetic Predisposition to DiseaseAce
Geographic AtrophyCcl2
Giant Cell ArteritisCcl2
GliosarcomaCcl2
GlomerulonephritisAce , Agt , Agtr2 , Ccl2
Glomerulonephritis, CrescenticCcl2
Glomerulonephritis, IGAAce , Agt , Agtr1a , Agtr2 , Ccl2
Glomerulonephritis, MembranoproliferativeCcl2
GlomerulosclerosisAgtr1a , Agtr2
Glomerulosclerosis, Focal SegmentalAgt , Agtr1a , Agtr2
Glucose IntoleranceJak2
Glycogen Storage Disease Type VAce
GranulomaCma1
Granuloma, Respiratory TractCcl2
Granulomatous Interstitial NephritisCcl2
Granulomatous VasculitisCcl2
Graves OphthalmopathyCcl2
Growth DisordersJak2
Guillain-Barre SyndromeCcl2
Hearing Loss, Noise-InducedCcl2
Heart Defects, CongenitalCma1
Heart DiseasesAgt , Jak2
Heart FailureAce , Agt , Agtr1a , Agtr2 , Ccl2 , Olr1 , Pdpk1
Heart Valve DiseasesCcl2 , Jak2
HemarthrosisCcl2
Hemolytic-Uremic SyndromeCcl2
HemorrhageAgt
Hepatitis, AlcoholicAgt
Hepatitis, AutoimmuneCcl2
Hernia, DiaphragmaticAgt , Agtr1a , Agtr1b
Hernias, Diaphragmatic, CongenitalAgtr2
Herpes SimplexCcl2
HIV InfectionsCcl2
Huntington DiseaseAgtr1a
HydronephrosisAgt
HyperaldosteronismAgtr1b
HyperalgesiaAgt , Ccl2 , Jak2
HyperemiaAgt
HyperglycemiaPrkcz
HyperhomocysteinemiaCcl2
HyperinsulinismAgt , Agtr1a , Ccl2
HyperlipidemiasCcl2
HyperoxaluriaCcl2
HypersensitivityAce , Agt , Ccl2
Hypersensitivity, DelayedCcl2
HypertensionAce , Agt , Agtr1a , Agtr1b , Agtr2 , Ccl2 , Cma1 , Olr1
Hypertension, EssentialAgt , Agtr1a
Hypertension, MalignantAgt
Hypertension, Pregnancy-InducedAce , Agt
Hypertension, PulmonaryAce , Agt , Agtr1a , Ccl2
Hypertension, RenalAgt , Agtr1a
Hypertension, RenovascularAce , Agtr1a , Agtr1b , Agtr2
Hypertensive NephropathyAgt , Agtr1a
HypertrophyAgt
Hypertrophy, Left VentricularAce , Agt , Agtr1a , Agtr2 , Cma1 , Prkcz
Hypertrophy, Right VentricularAce
HyperuricemiaJak2
HypoglycemiaAgtr2
HypokalemiaAgt
HypotensionAce , Agt
Hypoxia-Ischemia, BrainAgtr2 , Ccl2
Infant, Premature, DiseasesAce
Infarction, Middle Cerebral ArteryAce , Agt , Ccl2
Infertility, MaleAce
InflammationAgt , Agtr1a , Agtr2 , Ccl2 , Jak2
Inflammatory Bowel Disease 11Jak2
Inflammatory Bowel DiseasesAgt
InfluenzaCcl2
Influenza, HumanCcl2
Insulin ResistanceAce , Agtr2 , Ccl2 , Prkcz
Intellectual DisabilityAgtr2
Intestinal Reperfusion InjuryCcl2 , Jak2
Intracranial AneurysmAce , Ccl2
Invasive Pulmonary AspergillosisCcl2
IschemiaCcl2
Ischemic Attack, TransientAgt , Ccl2 , Jak2
Jaundice, ObstructiveCcl2
Keratitis, HerpeticCcl2
Kidney DiseasesAce , Agt , Agtr1a , Ccl2
Kidney Failure, ChronicAce , Agt , Agtr2 , Ccl2 , Olr1
Kidney Reperfusion InjuryAce , Ccl2
Leishmaniasis, CutaneousCcl2
LeukemiaAce , Jak2 , Prkcz
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveAce , Agt
Leukemia, Myeloid, AcuteCcl2 , Jak2
LeukostasisAce
LipodystrophyCcl2
Liver CirrhosisAce , Agt , Ccl2
Liver Cirrhosis, AlcoholicJak2
Liver Cirrhosis, BiliaryAce , Agt , Jak2
Liver Cirrhosis, ExperimentalAgt , Agtr1a , Ccl2 , Jak2
Liver DiseasesCcl2
Liver Failure, AcuteCcl2
Liver InjuryJak2
Liver Reperfusion InjuryCcl2 , Jak2
Lower Extremity Deep Vein ThrombosisCcl2
Lung DiseasesAce , Agtr1a , Ccl2
Lung Diseases, InterstitialCcl2 , Cma1
Lung InjuryCcl2
Lung NeoplasmsAce
Lupus Erythematosus, SystemicAce , Agtr2 , Ccl2 , Jak2
Lupus NephritisCcl2
Lyme NeuroborreliosisCcl2
Lymphoma, Large B-Cell, DiffusePdpk1
Macular DegenerationCcl2
Macular EdemaCcl2
Mammary Neoplasms, ExperimentalAgt , Agtr1a , Agtr2
Meconium Aspiration SyndromeAgt , Agtr2
MelanomaCcl2
Melanoma, Cutaneous MalignantAgt
Memory DisordersAce
Meningococcal InfectionsAce
Mental Retardation, X-LinkedAgtr2
Mesenteric Vascular OcclusionJak2
Metabolic Syndrome XAgt , Agtr1a , Ccl2
Microvascular Complications of Diabetes, Susceptibility To, 1Ace
Microvascular Complications of Diabetes, Susceptibility To, 2Ace
Microvascular Complications of Diabetes, Susceptibility To, 3Ace
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 4Ace
Microvascular Complications of Diabetes, Susceptibility To, 6Ace
Microvascular Complications of Diabetes, Susceptibility To, 7Ace
Mitral Valve ProlapseAce , Agt
Mouth NeoplasmsCcl2
Multiple MyelomaAce , Ccl2
Multiple Organ FailureCcl2
Multiple SclerosisCcl2
Muscular Dystrophy, DuchenneCcl2
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TOCcl2
MycosesCcl2
Myeloproliferative DisordersJak2
Myocardial InfarctionAce , Agt , Agtr1a , Ccl2 , Jak2 , Olr1
Myocardial IschemiaAgt , Ccl2 , Jak2
Myocardial Reperfusion InjuryAgt , Agtr1a , Ccl2 , Jak2 , Olr1
MyocarditisAce , Ccl2 , Cma1
Myocarditis, Autoimmune, ExperimentalCcl2
Nasal PolypsCcl2
NecrosisAgt
NeointimaAgt
Neoplasm InvasivenessCcl2
Neoplasm MetastasisAce , Agtr1a , Agtr2 , Ccl2
NephritisAce , Agtr1a , Ccl2
Nephritis, InterstitialCcl2
Nephropathy, Chronic TubulointerstitialCcl2
NephrosisAce , Agt
Nephrosis, Puromycin AminonucleosideAgt
Nephrotic SyndromeAce , Jak2
Neural Tube DefectsCcl2
Neuropathy, PainfulCcl2
Niemann-Pick Disease, Type CJak2
Non-alcoholic Fatty Liver DiseaseAce , Jak2
Nonarteritic Anterior Ischemic Optic NeuropathyAce
ObesityAce , Agt , Agtr2 , Ccl2 , Jak2
Obstetric Labor, PrematureCcl2
Ocular HypotensionAce
Oral Squamous Cell CarcinomaCcl2
OrchitisCcl2
OsteoporosisAce
OtosclerosisAgt
Ovarian CystsAgtr2
Oxygen-Induced RetinopathyCcl2
PainAce , Ccl2
Pancreatic NeoplasmsAce , Agtr2
PancreatitisCcl2
Pancreatitis, Acute NecrotizingCcl2
Parkinson DiseaseAce , Agtr1a
Peptic Ulcer HemorrhageAgt
Peri-ImplantitisCcl2
Periapical PeriodontitisCcl2
Periodontal CystCcl2
PeriodontitisCcl2
Peripheral Nerve InjuriesCcl2
Pituitary NeoplasmsAgtr1a
Placental InsufficiencyAgtr1a
Pleural DiseasesCcl2
PneumoniaAce , Ccl2
Pneumonia, AspirationAce
Pneumonia, BacterialCcl2
Pneumonia, PneumocystisCcl2
Pneumonia, ViralAce , Ccl2
Polycystic Kidney, Autosomal RecessiveAce
PolycythemiaAce , Jak2
Polycythemia VeraJak2
Postoperative Cognitive DysfunctionAgtr1a , Agtr1b
Pre-EclampsiaAce , Agt
Precancerous ConditionsAce
Prediabetic StateAgt
Pregnancy ComplicationsJak2
Prenatal Exposure Delayed EffectsAgtr1a , Agtr1b
Primary MyelofibrosisJak2
Proliferative Diabetic RetinopathyCcl2
Prostatic NeoplasmsAce , Jak2 , Prkcz
ProteinuriaAce , Agt , Agtr1a
Psychoses, Substance-InducedAce
Pulmonary AspergillosisCcl2
Pulmonary ContusionCcl2
Pulmonary Disease, Chronic ObstructiveAce , Ccl2 , Cma1
Pulmonary EdemaAgt , Ccl2
Pulmonary EmbolismCcl2
Pulmonary EmphysemaCcl2
Pulmonary FibrosisAce , Agt , Agtr1a , Agtr2 , Ccl2 , Cma1
Purpura, Schoenlein-HenochAce , Agt , Ccl2
PyelonephritisAce
Radiation Injuries, ExperimentalAgtr1a , Agtr2
Renal FibrosisAce
Renal InsufficiencyAce , Agt
Renal Insufficiency, ChronicAgtr1a , Agtr2
Renal Tubular DysgenesisAce , Agt , Agtr1a
Reperfusion InjuryAce , Agt , Agtr2 , Ccl2 , Jak2
Respiratory Distress Syndrome, AdultAce , Ccl2
Respiratory Tract DiseasesAce
Retina Reperfusion InjuryCcl2
Retinal DegenerationCcl2
Retinal DetachmentCcl2 , Jak2
Retinal VasculitisAgt
RetinitisCcl2
Retinopathy of PrematurityAgt
Rhinitis, AllergicAce
Rhinitis, Allergic, PerennialCcl2
Rhinitis, Allergic, SeasonalCma1
SarcoidosisAce , Agtr1a , Cma1
SarcomaCcl2
SchizophreniaCcl2
Sciatic NeuropathyAgt , Ccl2
Scleroderma, DiffuseAgt
Scleroderma, LimitedCcl2 , Jak2
Scleroderma, SystemicAce , Agt , Ccl2
ScrapieJak2
SeizuresAgt
SepsisCcl2 , Jak2
Sepsis-Associated EncephalopathyJak2
Severe Acute Respiratory SyndromeAce
Sick Sinus SyndromeAgt
SilicosisCcl2
Sleep Apnea, ObstructiveAce , Ccl2
Smith-Magenis SyndromeAce , Ccl2
Spinal Cord CompressionCcl2
Spinal Cord InjuriesJak2
Spinal DysraphismCcl2
Spondylitis, AnkylosingAce , Jak2
Staphylococcal InfectionsAce
Status EpilepticusCcl2
Stomach NeoplasmsAce , Agtr2
Stomach UlcerAgt
StrokeAce , Agt , Agtr2 , Ccl2 , Jak2
Thrombocythemia 3Jak2
Thrombocythemia, EssentialJak2
ThrombocytopeniaCcl2
ThrombocytosisJak2
ThromboembolismJak2
ThrombosisAgt
Thyroid DiseasesCcl2
Thyroid NeoplasmsCcl2
Transplant RejectionCcl2
Tuberculosis, PulmonaryCcl2
Urogenital AbnormalitiesAgtr2
UveitisAce , Ccl2
Uveitis, Acute AnteriorCcl2
Uveitis, AnteriorCcl2
Uveitis, Autoimmune, ExperimentalCcl2
Uveoretinitis, Autoimmune, ExperimentalCcl2
Vascular RemodelingAgt
Vascular System InjuriesAce , Agtr2
Vasculitis of the SkinCcl2
Vasospasm, IntracranialCcl2
Venous ThromboembolismAce
Venous ThrombosisCcl2 , Jak2
Ventricular Dysfunction, LeftAgt
Ventricular FibrillationAce
Ventricular RemodelingAce , Agtr1a
Vesico-Ureteral RefluxAgtr1a , Agtr2
Water-Electrolyte ImbalanceAgtr1b
Weight GainAce
Wet Macular DegenerationCcl2
Pathway Annotations Associated with Genes in the angiotensin II signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAgtr1a
adenosine signaling pathwayPdpk1 , Prkcz
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAgtr1a
aldosterone signaling pathwayJak2 , Pdpk1
altered Jak-Stat signaling pathwayJak2
amiodarone pharmacodynamics pathwayAgtr1a
amlodipine pharmacodynamics pathwayAgtr1a
angiotensin (1-7) signaling pathwayAce , Agt
angiotensin II signaling pathwayAce , Agt , Agtr1a , Agtr1b , Agtr2 , Ccl2 , Cma1 , Jak2 , Olr1 , Pdpk1 , Prkcz
angiotensin II signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b , Jak2
angiotensin II signaling pathway via AT2 receptorAgt , Agtr2
angiotensin III signaling pathwayAgt , Agtr1a , Agtr1b , Agtr2
angiotensin III signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b
angiotensin III signaling pathway via AT2 receptorAgt , Agtr2
angiotensin IV signaling pathwayAgt
angiotensin signaling pathwayAgt
atenolol pharmacodynamics pathwayAgtr1a
benazepril pharmacodynamics pathwayAce , Agt , Agtr1a
benazepril pharmacokinetics pathwayAce
betaxolol pharmacodynamics pathwayAgtr1a
bisoprolol pharmacodynamics pathwayAgtr1a
bupranolol drug pathwayAgtr1a
bupranolol pharmacodynamics pathwayAgtr1a
calcium/calcium-mediated signaling pathwayAgtr1a , Agtr1b
candesartan pharmacodynamics pathwayAce , Agt , Agtr1a
captopril pharmacodynamics pathwayAce , Agt , Agtr1a
carvedilol pharmacodynamics pathwayAgtr1a
ceramide signaling pathwayPrkcz
chemokine mediated signaling pathwayCcl2 , Jak2 , Prkcz
cilazapril pharmacodynamics pathwayAce , Agt , Agtr1a
cilazapril pharmacokinetics pathwayAce
diltiazem pharmacodynamics pathwayAgtr1a
disopyramide pharmacodynamics pathwayAgtr1a
dobutamine pharmacodynamics pathwayAgtr1a
eicosanoid signaling pathwayPrkcz
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaOlr1 , Pdpk1
enalapril pharmacodynamics pathwayAce , Agt , Agtr1a
enalapril pharmacokinetics pathwayAce
endocytosis pathwayPrkcz
endometrial cancer pathwayPdpk1
endothelin signaling pathwayJak2
epidermal growth factor/neuregulin signaling pathwayPrkcz
eprosartan pharmacodynamics pathwayAce , Agt , Agtr1a
erythropoietin signaling pathwayJak2
esmolol pharmacodynamics pathwayAgtr1a
FasL mediated signaling pathwayPdpk1
fibroblast growth factor signaling pathwayPdpk1
flecainde pharmacodynamics pathwayAgtr1a
forasartsn pharmacodynamics pathwayAce , Agt , Agtr1a
fosinopril pharmacodynamics pathwayAce , Agt , Agtr1a
fosinopril pharmacokinetics pathwayAce
fosphenytoin pharmacodynamics pathwayAgtr1a
G protein mediated signaling pathway via Galpha12/Galpha13 familyAgtr1a
G protein mediated signaling pathway via Galphai familyAgtr2
G protein mediated signaling pathway via Galphaq familyAgtr1a , Agtr1b
granulocyte-macrophage colony-stimulating factor signaling pathwayCcl2 , Jak2
growth hormone signaling pathwayJak2
hypertrophic cardiomyopathy pathwayAce
ibutilide pharmacodynamics pathwayAgtr1a
influenza A virus infection pathwayJak2
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPrkcz
insulin signaling pathwayPdpk1 , Prkcz
insulin-like growth factor signaling pathwayPdpk1 , Prkcz
interleukin-1 signaling pathwayPrkcz
interleukin-12 signaling pathwayJak2
interleukin-23 signaling pathwayCcl2 , Jak2
interleukin-27 signaling pathwayJak2
interleukin-3 signaling pathwayJak2
interleukin-4 signaling pathwayJak2
interleukin-5 signaling pathwayJak2
interleukin-6 signaling pathwayJak2
irbesartan pharmacodynamics pathwayAce , Agt , Agtr1a
isoprenaline pharmacodynamics pathwayAgtr1a
isradipine pharmacodynamics pathwayAgtr1a
Jak-Stat signaling pathwayJak2
kallikrein-kinin cascade pathwayAce
Leishmania infection pathwayJak2
leptin system pathwayJak2
levobunolol pharmacodynamics pathwayAgtr1a
lidocaine pharmacodynamics pathwayAgtr1a
lisinopril pharmacodynamics pathwayAce , Agt , Agtr1a
long term potentiationAgt
losartan pharmacodynamics pathwayAce , Agt , Agtr1a
measles infection pathwayJak2
metoprolol pharmacodynamics pathwayAgtr1a
mexiletine pharmacodynamics pathwayAgtr1a
moexipril pharmacodynamics pathwayAce , Agt , Agtr1a
moexipril pharmacokinetics pathwayAce
mTOR signaling pathwayPdpk1
Mycobacterium tuberculosis infection pathwayJak2
myocardial infarction pathwayAgt
nadolol pharmacodynamics pathwayAgtr1a
nebivolol pharmacodynamics pathwayAgtr1a
nifedipine pharmacodynamics pathwayAgtr1a
nimodipine pharmacodynamics pathwayAgtr1a
nisoldipine pharmacodynamics pathwayAgtr1a
nitrendipine pharmacodynamics pathwayAgtr1a
non-small cell lung cancer pathwayPdpk1
olmesartan pharmacodynamics pathwayAce , Agt , Agtr1a
penbutolol pharmacodynamics pathwayAgtr1a
perindopril pharmacodynamics pathwayAce , Agt , Agtr1a
phagocytosis pathwayOlr1
phenytoin pharmacodynamics pathwayAgtr1a
phosphatidylinositol 3-kinase class I signaling pathwayPdpk1
phosphatidylinositol 3-kinase-Akt signaling pathwayPdpk1
pindolol pharmacodynamics pathwayAgtr1a
platelet-derived growth factor signaling pathwayJak2
procainamide pharmacodynamics pathwayAgtr1a
propranolol pharmacodynamics pathwayAgtr1a
prostate cancer pathwayPdpk1
protein kinase C (PKC) signaling pathwayPdpk1 , Prkcz
quinapril pharmacodynamics pathwayAce , Agt , Agtr1a
quinapril pharmacokinetics pathwayAce
quinidine pharmacodynamics pathwayAgtr1a
ramipril pharmacodynamics pathwayAce , Agt , Agtr1a
ramipril pharmacokinetics pathwayAce
renin-angiotensin cascade pathwayAce , Agt , Agtr1a , Agtr1b , Agtr2 , Cma1
somatostatin signaling pathwayJak2
sotalol pharmacodynamics pathwayAgtr1a
sphingosine 1-phosphate signaling pathwayJak2
spirapril pharmacodynamics pathwayAce , Agt , Agtr1a
spirapril pharmacokinetics pathwayAce
telmisartan pharmacodynamics pathwayAce , Agt , Agtr1a
timolol pharmacodynamics pathwayAgtr1a
Toxoplasma gondii infection pathwayJak2
trandolapril pharmacodynamics pathwayAce , Agt , Agtr1a
trandolapril pharmacokinetics pathwayAce
transforming growth factor-beta Smad dependent signaling pathwayPdpk1
Trypanosoma cruzi infection pathwayAce
tumor necrosis factor mediated signaling pathwayPrkcz
type 2 diabetes mellitus pathwayPrkcz
type II interferon signaling pathwayJak2
valsartan pharmacodynamics pathwayAce , Agt , Agtr1a
vascular endothelial growth factor signaling pathwayCcl2 , Pdpk1 , Prkcz
verapamil pharmacodynamics pathwayAgtr1a
Wnt signaling, non-canonical pathwayPrkcz
Phenotype Annotations Associated with Genes in the angiotensin II signaling pathway

References Associated with the angiotensin II signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: