ANGIOTENSIN II SIGNALING PATHWAY (PW:0000244)

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Description

Agiotensin II (AgtII), the product of Ace action in the renin-angiotensin system, is probably the most potent of the biologically active peptides the pathway generates. The system, originally viewed as solely endocrine, is now regarded as an endocrine, paracrine and autocrine one, producing an array of diverse and many times opposing actions via both the 'classical' or circulatory and the local or 'tissue' routes. Overall AgtII elicits distinct responses through signaling via receptor type 1 and

Pathway Diagram:

Ariadne Genomics Inc. Agtr1b ---> Agtr1, G protein/ligand independent signaling protein kinase C (PKC) signaling pathway AgtII renin-angiotensin system signaling pathway Agtr1a ---> Agtr1, G protein/ligand independent signaling fluid homeostasis hormone release Agtr2 ---> Agtr2, G protein/ligand independent signaling vasoconstriction antiproliferation vasodilation Agtr2, G protein/ligand independent signaling angiotensin II signaling pathway via AT2 receptor angiotensin II signaling pathway via AT1 receptor AgtII ---> hormone release AgtII ---> fluid homeostasis AgtII ---> antiproliferation AgtII ---> vasoconstriction AgtII ---- Agtr2 AgtII ---- Agtr1b Agtr2 Agtr1a Agtr1b Agt Agt ---> AgtII Agtr1, G protein/ligand independent signaling G protein mediated signaling pathway via Galphai family G protein mediated signaling pathway via Galphaq family AgtII ---- Agtr1a AgtII ---> vasodilation
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Genes in Pathway:

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angiotensin II signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1581742
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1579760
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:629553
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1566502
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:1582323
G Cma1 chymase 1 JBrowse link 15 34,601,037 34,603,819 RGD:1581745
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1600094
G Olr1 oxidized low density lipoprotein receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:1580992
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:1581775
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:12910844
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:1642674
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1581825
RGD:5133683
RGD:2316188
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1581825
G Agtrap angiotensin II receptor-associated protein JBrowse link 5 164,888,069 164,898,387 RGD:2314353
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 JBrowse link 1 166,459,062 166,525,200 RGD:2316188
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5133417
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5133417
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:1581847
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:1581847
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:5133417
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:5133417
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:5133417
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:5133417
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:5133683
RGD:6478796
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:5133418
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:6478796
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582434
RGD:7401256
RGD:1582435
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1581825
RGD:7401256
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 JBrowse link 5 152,447,348 152,458,005 RGD:5133679
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:5133675
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:5133679
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:7401256
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:7401256
G Mtus1 microtubule associated scaffold protein 1 JBrowse link 16 54,240,892 54,386,131 RGD:5133679
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:5133675
G Slc9a6 solute carrier family 9 member A6 JBrowse link X 158,979,081 159,045,019 RGD:5133679
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:5133679
G Zbtb16 zinc finger and BTB domain containing 16 JBrowse link 8 52,980,226 53,146,765 RGD:5133679

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ProteinAgtIIangiotensin II generated from Agt via the renin-angiotensin cascade pathway

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the angiotensin II signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAgtr1a
adenosine signaling pathwayPdpk1 , Prkcz
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAgtr1a
aldosterone signaling pathwayJak2 , Pdpk1
alpha-linoleic acid metabolic pathwayPla2g6
altered Jak-Stat signaling pathwayJak2
amiodarone pharmacodynamics pathwayAgtr1a
amlodipine pharmacodynamics pathwayAgtr1a
angiotensin (1-7) signaling pathwayAce , Agt
angiotensin II signaling pathwayAce , Agt , Agtr1a , Agtr1b , Agtr2 , Ccl2 , Cma1 , Jak2 , Olr1 , Pdpk1 , Pla2g6 , Prkcz
angiotensin II signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b , Jak2
angiotensin II signaling pathway via AT2 receptorAgt , Agtr2
angiotensin III signaling pathwayAgt , Agtr1a , Agtr1b , Agtr2
angiotensin III signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b
angiotensin III signaling pathway via AT2 receptorAgt , Agtr2
angiotensin IV signaling pathwayAgt
angiotensin signaling pathwayAgt
arachidonic acid metabolic pathwayPla2g6
atenolol pharmacodynamics pathwayAgtr1a
benazepril pharmacodynamics pathwayAce , Agt , Agtr1a
benazepril pharmacokinetics pathwayAce
betaxolol pharmacodynamics pathwayAgtr1a
bisoprolol pharmacodynamics pathwayAgtr1a
bupranolol drug pathwayAgtr1a
bupranolol pharmacodynamics pathwayAgtr1a
calcium/calcium-mediated signaling pathwayAgtr1a , Agtr1b
candesartan pharmacodynamics pathwayAce , Agt , Agtr1a
captopril pharmacodynamics pathwayAce , Agt , Agtr1a
carvedilol pharmacodynamics pathwayAgtr1a
ceramide signaling pathwayPrkcz
chemokine mediated signaling pathwayCcl2 , Jak2 , Prkcz
cilazapril pharmacodynamics pathwayAce , Agt , Agtr1a
cilazapril pharmacokinetics pathwayAce
diltiazem pharmacodynamics pathwayAgtr1a
disopyramide pharmacodynamics pathwayAgtr1a
dobutamine pharmacodynamics pathwayAgtr1a
eicosanoid signaling pathwayPrkcz
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaOlr1 , Pdpk1
enalapril pharmacodynamics pathwayAce , Agt , Agtr1a
enalapril pharmacokinetics pathwayAce
endocytosis pathwayPrkcz
endometrial cancer pathwayPdpk1
endothelin signaling pathwayJak2
epidermal growth factor/neuregulin signaling pathwayPrkcz
eprosartan pharmacodynamics pathwayAce , Agt , Agtr1a
erythropoietin signaling pathwayJak2
esmolol pharmacodynamics pathwayAgtr1a
ether lipid metabolic pathwayPla2g6
ether lipid metabolic pathwayPla2g6
FasL mediated signaling pathwayPdpk1
Fc epsilon receptor mediated signaling pathwayPla2g6
Fc gamma receptor mediated signaling pathwayPla2g6
fibroblast growth factor signaling pathwayPdpk1
flecainde pharmacodynamics pathwayAgtr1a
forasartsn pharmacodynamics pathwayAce , Agt , Agtr1a
fosinopril pharmacodynamics pathwayAce , Agt , Agtr1a
fosinopril pharmacokinetics pathwayAce
fosphenytoin pharmacodynamics pathwayAgtr1a
G protein mediated signaling pathway via Galpha12/Galpha13 familyAgtr1a
G protein mediated signaling pathway via Galphai familyAgtr2
G protein mediated signaling pathway via Galphaq familyAgtr1a , Agtr1b
glutamate signaling pathwayPla2g6
glycerophospholipid metabolic pathwayPla2g6
gonadotropin-releasing hormone signaling pathwayPla2g6
granulocyte-macrophage colony-stimulating factor signaling pathwayCcl2 , Jak2
growth hormone signaling pathwayJak2
hypertrophic cardiomyopathy pathwayAce
ibutilide pharmacodynamics pathwayAgtr1a
influenza A virus infection pathwayJak2
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPrkcz
insulin signaling pathwayPdpk1 , Prkcz
insulin-like growth factor signaling pathwayPdpk1 , Prkcz
interleukin-1 signaling pathwayPrkcz
interleukin-12 signaling pathwayJak2
interleukin-23 signaling pathwayCcl2 , Jak2
interleukin-27 signaling pathwayJak2
interleukin-3 signaling pathwayJak2
interleukin-4 signaling pathwayJak2
interleukin-5 signaling pathwayJak2
interleukin-6 signaling pathwayJak2
irbesartan pharmacodynamics pathwayAce , Agt , Agtr1a
isoprenaline pharmacodynamics pathwayAgtr1a
isradipine pharmacodynamics pathwayAgtr1a
Jak-Stat signaling pathwayJak2
kallikrein-kinin cascade pathwayAce
Leishmania infection pathwayJak2
leptin system pathwayJak2
levobunolol pharmacodynamics pathwayAgtr1a
lidocaine pharmacodynamics pathwayAgtr1a
linoleic acid metabolic pathwayPla2g6
lisinopril pharmacodynamics pathwayAce , Agt , Agtr1a
long term depressionPla2g6
long term potentiationAgt
losartan pharmacodynamics pathwayAce , Agt , Agtr1a
measles infection pathwayJak2
metoprolol pharmacodynamics pathwayAgtr1a
mexiletine pharmacodynamics pathwayAgtr1a
mitogen activated protein kinase signaling pathwayPla2g6
moexipril pharmacodynamics pathwayAce , Agt , Agtr1a
moexipril pharmacokinetics pathwayAce
mTOR signaling pathwayPdpk1
Mycobacterium tuberculosis infection pathwayJak2
myocardial infarction pathwayAgt
nadolol pharmacodynamics pathwayAgtr1a
nebivolol pharmacodynamics pathwayAgtr1a
nifedipine pharmacodynamics pathwayAgtr1a
nimodipine pharmacodynamics pathwayAgtr1a
nisoldipine pharmacodynamics pathwayAgtr1a
nitrendipine pharmacodynamics pathwayAgtr1a
non-small cell lung cancer pathwayPdpk1
olmesartan pharmacodynamics pathwayAce , Agt , Agtr1a
penbutolol pharmacodynamics pathwayAgtr1a
perindopril pharmacodynamics pathwayAce , Agt , Agtr1a
phagocytosis pathwayOlr1
phenytoin pharmacodynamics pathwayAgtr1a
phosphatidylinositol 3-kinase class I signaling pathwayPdpk1
phosphatidylinositol 3-kinase-Akt signaling pathwayPdpk1
pindolol pharmacodynamics pathwayAgtr1a
platelet-derived growth factor signaling pathwayJak2
procainamide pharmacodynamics pathwayAgtr1a
propranolol pharmacodynamics pathwayAgtr1a
prostate cancer pathwayPdpk1
protein kinase C (PKC) signaling pathwayPdpk1 , Prkcz
quinapril pharmacodynamics pathwayAce , Agt , Agtr1a
quinapril pharmacokinetics pathwayAce
quinidine pharmacodynamics pathwayAgtr1a
ramipril pharmacodynamics pathwayAce , Agt , Agtr1a
ramipril pharmacokinetics pathwayAce
renin-angiotensin cascade pathwayAce , Agt , Agtr1a , Agtr1b , Agtr2 , Cma1
somatostatin signaling pathwayJak2
sotalol pharmacodynamics pathwayAgtr1a
sphingosine 1-phosphate signaling pathwayJak2
spirapril pharmacodynamics pathwayAce , Agt , Agtr1a
spirapril pharmacokinetics pathwayAce
telmisartan pharmacodynamics pathwayAce , Agt , Agtr1a
timolol pharmacodynamics pathwayAgtr1a
Toxoplasma gondii infection pathwayJak2 , Pla2g6
trandolapril pharmacodynamics pathwayAce , Agt , Agtr1a
trandolapril pharmacokinetics pathwayAce
transforming growth factor-beta Smad dependent signaling pathwayPdpk1
Trypanosoma cruzi infection pathwayAce
tumor necrosis factor mediated signaling pathwayPrkcz
type 2 diabetes mellitus pathwayPrkcz
type II interferon signaling pathwayJak2
valsartan pharmacodynamics pathwayAce , Agt , Agtr1a
vascular endothelial growth factor signaling pathwayCcl2 , Pdpk1 , Pla2g6 , Prkcz
verapamil pharmacodynamics pathwayAgtr1a
Wnt signaling, non-canonical pathwayPrkcz
Phenotype Annotations Associated with Genes in the angiotensin II signaling pathway

References Associated with the angiotensin II signaling pathway:

Ontology Path Diagram:

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