PHOSPHATIDYLINOSITOL 3-KINASE-AKT SIGNALING PATHWAY (PW:0000232)

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Description

Phosphatidylinositol 3-kinase-Akt signaling pathway plays a crucial role in many cellular processes. The PI3K generally referenced is the class IA lipid kinase acting downstream of receptor tyrosine kinases (RTKs). PI3Ks represent a large family of lipid kinases that phosphorylate the 3-hydroxy group of the inositol ring of membrane phosphatidylinositols (PtsIns). Based on substrate preferences and sequence similarity they are divided into three classes: class I, II and III. Class I is further s

Pathway Diagram:

Ariadne Genomics Inc. PS473 PT308 P-tyrosine receptor tyrosine kinase activated Akt members Pi3k-Akt cytoplasmic targets Pi3k-Akt nuclear targets activated Akt members --+> insulin responsive facilitative sugar transporter mediated glucose transport pathway activated Akt members --+> mTOR signaling pathway mTOR signaling pathway insulin responsive facilitative sugar transporter mediated glucose transport pathway activated Akt members ---| forkhead signaling pathway Akt3 Akt2 Akt1 PIP3 PIP2 Inpp5d ---| PIP3 Pten ---| PIP3 cell survival pro-growth Inppl1 ---| PIP3 Pten Pdpk1 Pik3ca Pik3ca --+> PIP2 Pdpk1 --+> Akt1 a second kinase a second kinase --+> Akt1 cell proliferation activated Akt members ---> cell survival activated Akt members ---> pro-growth activated Akt members ---> cell proliferation Pik3r1 Pik3r2 Pik3r3 Pik3cb Pik3cd Inpp5d Inppl1 forkhead signaling pathway
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Genes in Pathway:

show annotations for term's descendants       view all columns
phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:625444
RGD:2290458
RGD:6484113
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:632179
RGD:2290458
RGD:6484113
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:2290458
RGD:6484113
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6484113
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6484113
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6484113
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6484113
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6484113
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:6484113
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6484113
G Foxo4 forkhead box O4 JBrowse link X 71,155,284 71,162,158 RGD:6484113
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:6484113
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6484113
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:6484113
G Inpp5d inositol polyphosphate-5-phosphatase D JBrowse link 9 94,745,220 94,850,778 RGD:2302068
G Inppl1 inositol polyphosphate phosphatase-like 1 JBrowse link 1 166,898,177 166,912,524 RGD:2302068
G Kpna1 karyopherin subunit alpha 1 JBrowse link 11 67,652,573 67,717,180 RGD:6484113
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:6484113
G Mapkap1 mitogen-activated protein kinase associated protein 1 JBrowse link 3 13,484,952 13,701,772 RGD:6484113
G Mlst8 MTOR associated protein, LST8 homolog JBrowse link 10 13,839,250 13,845,001 RGD:6484113
G Mtor mechanistic target of rapamycin JBrowse link 5 165,263,813 165,373,967 RGD:6484113
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:2290458
RGD:6484113
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 JBrowse link 13 26,145,989 26,394,505 RGD:11535053
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 JBrowse link 19 41,731,845 41,798,451 RGD:11535053
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:2290458
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:2290458
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:2290458
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:2290458
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:2290458
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:2290458
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:11535052
G Ppp2cb protein phosphatase 2 catalytic subunit beta JBrowse link 16 62,273,276 62,294,767 RGD:11535052
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha JBrowse link 1 60,717,386 60,736,629 RGD:11535052
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta JBrowse link 8 55,279,278 55,311,768 RGD:11535052
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha JBrowse link 15 43,673,958 43,733,182 RGD:11535052
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6484113
G Prkdc protein kinase, DNA activated, catalytic polypeptide JBrowse link 11 89,293,547 89,510,948 RGD:6484113
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:2290458
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6484113
G Rictor RPTOR independent companion of MTOR, complex 2 JBrowse link 2 56,013,898 56,105,818 RGD:6484113
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:6484113
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6484113
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6484113
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta JBrowse link 3 160,391,108 160,399,931 RGD:6484113
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon JBrowse link 10 63,884,338 63,921,709 RGD:6484113
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma JBrowse link 12 23,789,547 23,817,884 RGD:6484113
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta JBrowse link 14 83,053,041 83,062,424 RGD:6484113
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta JBrowse link 6 43,463,294 43,493,816 RGD:6484113
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta JBrowse link 7 75,573,553 75,598,295 RGD:6484113
altered phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:2313763
RGD:5133243
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:2313408
RGD:2313763
RGD:5490965
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:2313763
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:2313763
RGD:4143515
RGD:5133242
RGD:5133243
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:2313763
RGD:2326139
RGD:4143515
RGD:5133242
RGD:5490965

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional Classactivated Akt members
Gene GroupPi3k-Akt cytoplasmic targets
Gene GroupAkt nuclear targets

Pathway Gene Annotations

Disease Annotations Associated with Genes in the phosphatidylinositol 3-kinase-Akt signaling pathway
Disease TermsGene Symbols
Abnormalities, MultipleChuk , Gsk3b , Pten
Acute Kidney InjuryBad , Cdkn1b , Gsk3b , Mtor
AdenocarcinomaMtor , Pik3ca , Pten
Adenocarcinoma of EsophagusPik3ca
Adenocarcinoma of LungAkt1 , Foxo3 , Pik3ca , Ppp2r1a , Raf1 , Sfn
Adenocarcinoma, ColorectalCdkn1a
Adenocarcinoma, ProstaticAkt1 , Pik3ca , Ppp2r1a , Pten
Adenoma, Liver CellCdkn1b , Pten
Adenomatous Polyposis ColiAkt1
Adrenal Gland NeoplasmsPrkaca
Adrenocortical CarcinomaPik3ca
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Aging, PrematureCdkn1a , Foxo1
AIDS-Associated NephropathyMtor
Alcohol-Induced DisordersFoxo4
Alzheimer DiseaseAkt1 , Bad , Foxo3 , Gsk3a , Gsk3b , Hsp90aa1 , Pik3r1 , Slc2a4
Amphetamine-Related DisordersAkt1
Amyotrophic Lateral SclerosisAkt1 , Casp9 , Gsk3a , Gsk3b , Map3k5
Angina, UnstableAkt1
AngiomyolipomaMtor , Pten
AnisometropiaPten
Aortic Valve, Calcification ofAkt1
Arsenic PoisoningCdkn1a
Arterial InjuryMap3k5
Arthritis, ExperimentalAkt1 , Gsk3b , Map3k5 , Mtor , Pik3cd
Arthritis, RheumatoidFoxo3 , Hsp90aa1
AsthmaChuk , Ppp2ca , Pten
AstrocytomaAkt1
AtaxiaPten
AtherosclerosisAkt1
Atrial FibrillationCdkn1a
Autism Spectrum DisorderPten
Autistic DisorderPten
Bacterial InfectionsCasp9
Bardet-Biedl SyndromeAkt3
Barrett EsophagusCdkn1a
Biliary AtresiaPten
Bipolar DisorderAkt1 , Gsk3a , Gsk3b
Bone Diseases, DevelopmentalChuk
Bowen's DiseaseCdkn1a
Brain InjuriesAkt1 , Bad , Cdkn1a , Cdkn1b , Gsk3b
Brain IschemiaAkt1 , Bad , Casp9 , Prkaca , Src , Ywhab
Brain NeoplasmsPten
Breast AdenocarcinomaAkt1 , Pik3ca
Breast Cancer, FamilialPik3r3
Breast NeoplasmsAkt1 , Akt2 , Bad , Casp9 , Cdkn1a , Cdkn1b , Hsp90aa1 , Mtor , Pdpk1 , Pik3ca , Pik3r1 , Ppp2r1a , Pten , Raf1 , Src
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Akt1 , Pik3ca
Burkitt LymphomaPik3r1
BurnsBad , Gsk3b , Mtor
CarcinogenesisGsk3b
CarcinomaCdkn1a , Pik3r1 , Pten , Ywhaz
Carcinoma in SituAkt1 , Pten , Sfn
Carcinoma, Adenoid CysticFoxo3 , Pik3ca , Prkdc , Pten
Carcinoma, Basal CellPik3ca
Carcinoma, EndometrioidCdkn1b , Pten
Carcinoma, HepatocellularAkt1 , Akt2 , Cdkn1b , Mtor , Pik3ca , Pten , Sfn
Carcinoma, Intraductal, NoninfiltratingCdkn1a , Src
Carcinoma, Non-Small-Cell LungAkt1 , Akt2 , Foxo3 , Pik3ca , Pten , Raf1
Carcinoma, Pancreatic DuctalCdkn1a
Carcinoma, Renal CellAkt1 , Bad , Cdkn1b , Mtor , Pik3ca , Pten
Carcinoma, Small CellMtor
Carcinoma, Squamous CellAkt1 , Cdkn1a , Pik3ca , Prkdc , Sfn
Carcinoma, Squamous Cell of Head and NeckAkt1 , Pik3ca , Ppp2r1a , Pten
Carcinoma, Transitional CellCdkn1a , Cdkn1b , Sfn
CardiomegalyAkt1 , Bad , Gsk3b , Mtor , Pten , Slc2a4 , Src
CardiomyopathiesAkt1 , Map3k5 , Ywhah
Cardiomyopathy, DilatedRaf1
CARDIOMYOPATHY, DILATED, 1NNRaf1
Cardiomyopathy, HypertrophicPrkaca , Raf1
Cardiomyopathy, Hypertrophic, FamilialRaf1
Carotid Artery InjuriesFoxo3 , Map3k5
CataractPten
Cell Transformation, NeoplasticPhlpp1
Cerebral HemorrhageMtor
Cerebral InfarctionMap3k5
Ceroid Lipofuscinosis, Neuronal, 6Gsk3b
Cervical Intraepithelial NeoplasiaCdkn1a , Cdkn1b , Pten
ChloracneCdkn1b
CholangiocarcinomaPrkaca , Pten
Cholesteatoma, CongenitalCdkn1a
Cholesteatoma, Middle EarCdkn1a
ChondrosarcomaMtor
Chromosomal InstabilityPpp2r2a
Chronic Allograft DysfunctionMtor
Chronic Cerebral HypoperfusionMap3k5
Classical Lissencephalies and Subcortical Band HeterotopiasYwhae
Cleft PalateChuk
Cocoon SyndromeChuk
Cognition DisordersMap3k5
ColitisChuk , Src
Colonic NeoplasmsAkt1 , Akt2 , Bad , Cdkn1a , Pik3ca , Pik3r1 , Pten , Src
Colorectal NeoplasmsAkt1 , Akt2 , Mtor , Pik3ca , Pik3r1 , Ppp2r1a , Pten , Raf1
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Coronary Artery DiseaseAkt1
COWDEN SYNDROME 5Pik3ca
Craniofacial AbnormalitiesPten
Currarino TriadPik3ca
Cystadenocarcinoma, SerousCdkn1a
Cystitis, InterstitialMtor
DehydrationYwhaz
Dementia, VascularMtor
Depressive DisorderGsk3a , Gsk3b
Dermatitis, ContactHsp90aa1
Developmental DisabilitiesAkt3 , Pten
Diabetes MellitusMap3k5 , Pten
Diabetes Mellitus, ExperimentalAkt1 , Bad , Casp9 , Cdkn1a , Foxo3 , Gsk3a , Hsp90aa1 , Map3k5 , Pik3r1 , Slc2a4 , Ywhah
Diabetes Mellitus, New-Onset after TransplantationMtor
Diabetes Mellitus, Type 1Casp9 , Foxo1
Diabetes Mellitus, Type 2Akt1 , Akt2 , Bad , Casp9 , Foxo1 , Gsk3b , Inppl1 , Pik3r1 , Ppp2ca , Slc2a4 , Src
Diabetic CardiomyopathiesBad
Diabetic CystopathyBad
Diabetic NephropathiesCdkn1b , Mtor , Pten
Diabetic NeuropathiesBad
Diabetic RetinopathyCasp9
Disease Models, AnimalAkt1
Disease ProgressionPpp2r1a , Pten
Drug-Induced Liver InjuryBad , Map3k5 , Prkdc
Dyskinesia, Drug-InducedMtor
EdemaCasp9
EmphysemaPpp2r2a
Encephalomyelitis, Autoimmune, ExperimentalCasp9
Endometrial HyperplasiaPten
Endometrial NeoplasmsCdkn1a , Cdkn1b , Pik3ca , Pten , Sfn
Enterocolitis, NecrotizingMap3k5
Epidermal NevusPik3ca
EpilepsyAkt1
Epilepsy, AbsenceYwhaz
Epilepsy, Temporal LobeFoxo3 , Mtor
Erectile DysfunctionAkt1 , Bad
Esophageal NeoplasmsCdkn1a , Sfn
Esophageal Squamous Cell CarcinomaCdkn1a , Sfn
Facial AsymmetryPik3ca
Fallopian Tube NeoplasmsCdkn1b
Fatty LiverPten
Fetal Alcohol Spectrum DisordersPten
Fetal DiseasesChuk
FibrosisAkt1 , Cdkn1b
Frontotemporal Lobar DegenerationHsp90aa1
Fuchs' Endothelial DystrophyCdkn1a
Gastrointestinal NeoplasmsPik3ca , Pten
Genetic Diseases, InbornPik3r2 , Pten
GlaucomaBad , Cdkn1b
Glaucoma, Primary Open AngleCdkn1a
GlioblastomaAkt1 , Mtor , Pik3ca , Pik3r1 , Pten
GliomaAkt2 , Bad , Pik3ca , Pten , Raf1
Glomerulonephritis, CrescenticMtor
Glomerulonephritis, MembranoproliferativeCdkn1b
Glomerulonephritis, MembranousCdkn1b , Map3k5
Growth DisordersPik3ca
Growth Hormone-Secreting Pituitary AdenomaCdkn1a
Hamartoma Syndrome, MultipleAkt1 , Pik3ca , Pten
Head and Neck NeoplasmsPik3ca
Hearing Loss, Cisplatin-InducedGsk3b
Hearing Loss, Noise-InducedCdkn1a
Heart ArrestAkt1
Heart DiseasesCasp9 , Ppp2ca
Heart FailureFoxo1 , Gsk3b , Map3k5 , Mtor , Pdpk1 , Ppp2ca , Prkaca , Slc2a4
Helicobacter InfectionsCdkn1b
HemangiomaPten
Hemangioma, CapillaryAkt3
Hemangioma, Cavernous, Central Nervous SystemPten
HemimegalencephalyPik3ca
Hepatic EncephalopathyPrkdc
HepatomegalyPten
HIV InfectionsCdkn1a , Hsp90aa1
Huntington DiseaseMap3k5
HyperalgesiaMtor , Raf1
HyperinsulinismPten
HyperoxiaCdkn1a
Hyperparathyroidism, PrimaryCdkn1b
HyperplasiaAkt1 , Cdkn1a , Pik3ca
HypertensionAkt1 , Akt2 , Bad , Gsk3b , Inppl1 , Mtor , Pik3r1 , Pten , Src , Ywhaz
Hypertension, PortalHsp90aa1 , Mtor , Pik3r1 , Pten
Hypertension, PulmonaryCdkn1a , Cdkn1b , Mtor , Slc2a4
Hypertension, RenalCdkn1a
HypertriglyceridemiaMtor
HypertrophyPten
Hypertrophy, Left VentricularCdkn1b , Foxo3 , Gsk3a , Mtor , Pten
Hypertrophy, Right VentricularAkt1 , Mtor
Hypoglossal Nerve InjuriesPrkaca
HypoglycemiaAkt2 , Inppl1 , Pik3r1
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
HypothyroidismBad
HypovolemiaCdkn1a
Hypoxia-Ischemia, BrainFoxo3 , Map3k5
Idiopathic Interstitial PneumoniasMtor
Immunodeficiency 14Pik3cd
IMMUNODEFICIENCY 26 WITH OR WITHOUT NEUROLOGIC ABNORMALITIESPrkdc
Immunodeficiency 36Pik3r1
Infarction, Middle Cerebral ArteryBad , Mtor
InflammationAkt1 , Chuk , Mtor
Inflammatory Bowel Disease 11Cdkn1a
Insulin ResistanceAkt2 , Bad , Foxo1 , Inppl1 , Pik3r1 , Pten , Slc2a4
Intellectual DisabilityPten
Intermittent ClaudicationBad
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsCdkn1a , Cdkn1b
Intimal HyperplasiaFoxo3
IschemiaAkt2 , Raf1
Ischemic Attack, TransientBad , Casp9 , Map3k5 , Pten
Juvenile Polyposis SyndromePten
KeloidSfn
KeratoconusFoxo1
Keratosis, SeborrheicPik3ca
Kidney DiseasesCdkn1a
Kidney Failure, ChronicMtor
Kidney NeoplasmsAkt1 , Cdkn1b , Raf1
Kidney Reperfusion InjuryMap3k5 , Src
Language Development DisordersPten
Laryngeal NeoplasmsCdkn1a
LeiomyomaPten
LEOPARD SyndromePten , Raf1
LEOPARD syndrome, 2Raf1
LeukemiaBad , Pten
Leukemia, Megakaryoblastic, AcutePten
Leukemia, Myeloid, AcuteCdkn1b , Foxo1
Leukemia, Promyelocytic, AcuteAkt1
LeukoencephalopathiesCdkn1b
Leukoplakia, OralCdkn1a
Leydig Cell TumorCdkn1b
Lichen Planus, OralCdkn1a
Limb Deformities, CongenitalChuk
Lip NeoplasmsCdkn1a
Lipodystrophy, Familial PartialAkt2
LipomaPten
LipomatosisPten
Liver Cirrhosis, BiliaryCdkn1a
Liver Cirrhosis, ExperimentalCdkn1a , Inpp5d , Inppl1 , Mtor , Ywhag , Ywhaz
Liver NeoplasmsAkt1 , Cdkn1a , Cdkn1b , Pik3ca , Raf1
Liver Neoplasms, ExperimentalCdkn1a , Ppp2ca
Liver Reperfusion InjuryBad
Long QT SyndromePten
Lung DiseasesPrkdc
Lung InjuryMtor
Lung NeoplasmsAkt1 , Cdkn1a , Cdkn1b , Mtor , Pik3ca , Ppp2r1b , Pten , Raf1
Lupus Erythematosus, SystemicYwhab
Lupus NephritisMtor
Lymphatic MetastasisCdkn1a , Cdkn1b , Pten , Sfn
LymphomaPten
Lymphoma, Large B-Cell, DiffusePdpk1 , Pik3ca , Pik3cb , Pik3cd
Lymphoma, Large-Cell, AnaplasticHsp90aa1
Lymphoma, Mantle-CellGsk3b , Mtor , Pik3cd
Lymphoma, Non-HodgkinPik3ca
Lymphoma, T-CellAkt1 , Cdkn1a
Macrocephaly Autism SyndromePten
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
Macular DegenerationBad , Cdkn1a , Cdkn1b
Malformations of Cortical DevelopmentAkt3 , Mtor , Pik3ca
Mammary Neoplasms, AnimalCdkn1a , Pik3r1 , Ywhaz
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Casp9 , Cdkn1b , Mtor , Pik3r1 , Pten , Ywhaz
Marijuana AbuseAkt1
Massive Hepatic NecrosisPrkdc
Maxillary Sinus NeoplasmsCdkn1a
MedulloblastomaPik3ca
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3 , Pten
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
MelanomaAkt1 , Cdkn1a , Map3k5 , Mtor , Pik3ca , Pik3r1 , Ppp2ca , Pten , Raf1
Melanoma, Cutaneous Malignant, Susceptibility To, 1Akt1 , Pik3ca , Ppp2ca , Pten , Raf1
Meningeal NeoplasmsAkt1
MeningiomaAkt1 , Pten
Meningioma, FamilialPten
MENTAL RETARDATION, AUTOSOMAL DOMINANT 36Ppp2r1a
MesotheliomaCdkn1b , Mtor
Mesothelioma, MalignantCdkn1a , Raf1
Metabolic Syndrome XInppl1
Micronuclei, Chromosome-DefectivePpp2r2a
Mild Cognitive ImpairmentHsp90aa1
Mood DisordersAkt1
Motor Skills DisordersPten
Mouth NeoplasmsPik3ca , Sfn
Multiple Endocrine NeoplasiaCdkn1b
Multiple Endocrine Neoplasia, Type IVCdkn1b
Multiple MyelomaPik3ca
Muscular AtrophyAkt1 , Chuk , Gsk3b , Mtor
Muscular DystrophiesPten
Muscular Dystrophy, AnimalMtor
Muscular Dystrophy, FacioscapulohumeralCdkn1a
Myelodysplastic SyndromesCdkn1b
Myocardial InfarctionAkt1 , Cdkn1b , Gsk3b , Map3k5 , Mtor
Myocardial IschemiaPpp2ca
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Casp9 , Gsk3b , Pten , Slc2a4
Nasopharyngeal carcinomaAkt2 , Pik3ca , Pten
Nasopharyngeal NeoplasmsPik3ca
Nematode InfectionsPik3r1
NeointimaFoxo4 , Map3k5
Neoplasm InvasivenessPten , Src
Neoplasm MetastasisAkt2 , Cdkn1a , Hsp90aa1 , Mtor , Pten , Src , Ywhae
Neoplasm Recurrence, LocalYwhaz
NeoplasmsPik3ca , Pik3r1 , Pten , Src
Neoplastic Syndromes, HereditaryPik3ca , Pten
NephritisMtor
Nephrosis, LipoidCdkn1a
Nerve Sheath NeoplasmsPten
Nervous System DiseasesCasp9
NeuroblastomaPik3ca
Neurodevelopmental DisordersPten
Neuroendocrine TumorsCdkn1b
Neuroma, AcousticCdkn1a
Neurotoxicity SyndromesMtor
Noonan SyndromeRaf1
Noonan Syndrome 5Raf1
ObesityAkt1 , Akt2 , Bad , Cdkn1b , Foxo3 , Inppl1 , Mtor , Pik3r1
Ocular HypertensionCdkn1a
OpsismodysplasiaInppl1
Oral Squamous Cell CarcinomaCdkn1a
OsteoarthritisBad , Mtor , Ppp2r1a , Ywhaq
Osteoarthritis, KneeHsp90aa1
OsteochondrodysplasiasPten
OsteosarcomaAkt1
Ovarian Epithelial CancerPik3ca
Ovarian NeoplasmsAkt1 , Akt2 , Cdkn1a , Cdkn1b , Mtor , Pik3ca , Pik3r1 , Pten , Sfn
PainAkt1
Pancreatic AdenocarcinomaPik3ca
Pancreatic CarcinomaCdkn1a , Mtor
Pancreatic NeoplasmsAkt2 , Mtor , Pten
Pancreatitis, ChronicBad
Pancreatitis, Experimental, Acute Cdkn1a
Papillary Renal Cell Carcinoma, SporadicMtor , Pik3ca
PapillomaCdkn1a
Papilloma, InvertedCdkn1a
ParaplegiaAkt1 , Foxo4
Parkinson DiseaseAkt1 , Gsk3b , Map3k5 , Ppp2ca
Parkinsonian DisordersBad , Gsk3a , Mtor , Src
Penile NeoplasmsPik3ca
Peripheral Nervous System DiseasesCasp9
Peripheral Nervous System NeoplasmsPten
PeritonitisGsk3b
Phyllodes TumorCdkn1a
Pigmented Nodular Adrenocortical Disease, Primary, 4Prkaca
Pituitary NeoplasmsCdkn1a , Cdkn1b
Pleomorphic Xanthoastrocytoma Ywhag
Pneumonia, BacterialChuk
PoisoningGsk3b , Prkdc
Polycystic Kidney DiseasesMtor
Polycystic Kidney, Autosomal DominantCdkn1a , Mtor
Polycystic Kidney, Autosomal RecessiveAkt1 , Mtor , Pik3ca , Src
PolydactylyPten
PolymicrogyriaAkt3
Precursor T-Cell Lymphoblastic Leukemia-LymphomaMtor
Prostate Cancer, SomaticPten
Prostatic HyperplasiaBad , Pten
Prostatic Intraepithelial NeoplasiaCdkn1b , Pten
Prostatic NeoplasmsAkt1 , Bad , Casp9 , Cdkn1a , Cdkn1b , Chuk , Foxo1 , Foxo3 , Gsk3b , Mtor , Phlpp1 , Pik3ca , Pik3cd , Pik3r1 , Ppp2ca , Prkdc , Pten , Src
Proteus SyndromeAkt1 , Pten
PsoriasisCdkn1a
Psychoses, Substance-InducedAkt1
Pten Hamartoma Tumor Syndrome with Granular Cell TumorPten
Pulmonary Disease, Chronic ObstructiveFoxo3
Pulmonary FibrosisBad
RASopathiesRaf1
Rectal NeoplasmsCdkn1b , Pik3ca
Reperfusion InjuryAkt1 , Bad , Casp9 , Cdkn1a , Cdkn1b , Inpp5d , Pik3r1 , Pten , Src
Retina Reperfusion InjuryBad
Retinal DetachmentCasp9
Retinal NeovascularizationMtor
Retinitis PigmentosaPten
Rhabdomyosarcoma, AlveolarFoxo1
Salivary Gland NeoplasmsCdkn1a
SarcoidosisCdkn1a
SarcomaPik3ca
SarcopeniaCdkn1a , Foxo4
SchizophreniaAkt1 , Gsk3a , Gsk3b , Kpna1 , Mtor , Pik3cb , Ywhah
Sciatic NeuropathyCdkn1b , Mtor
Scleroderma, LocalizedCdkn1a
Sebaceous Gland NeoplasmsCdkn1a
SeizuresBad , Map3k5 , Pten , Ywhab , Ywhaz
Senile CataractCdkn1b
Senior Loken SyndromeAkt3
SepsisBad , Cdkn1a , Gsk3b , Mtor
Septic PeritonitisPik3r1
Severe Combined ImmunodeficiencyPrkdc
Sezary SyndromeCdkn1b , Pten
Shock, HemorrhagicBad , Mtor
SHORT SyndromePik3r1
Sinonasal NeoplasmsCdkn1a
Skin AbnormalitiesChuk
Skin DiseasesPten
Skin NeoplasmsAkt1 , Cdkn1a
Small Cell Lung CarcinomaAkt1 , Pik3ca , Pten
Small-For-Size SyndromeBad
Smith-Kingsmore SyndromeMtor
Spinal Cord InjuriesAkt1 , Cdkn1b , Foxo3 , Map3k5 , Mtor
Spinal Cord Reperfusion InjuryBad
Squamous Cell Carcinoma of the LungAkt1 , Pik3ca , Pten
Squamous Cell Carcinoma of the TongueCdkn1a
Status EpilepticusFoxo3 , Gsk3b , Mtor , Src
Stomach DiseasesPten
Stomach NeoplasmsCdkn1a , Cdkn1b , Pik3ca , Ppp2r1a
Stomach UlcerBad , Foxo4
StrokeAkt1 , Src
Substance-Related DisordersPten
Tachycardia, VentricularRaf1
TauopathiesGsk3b
Temporomandibular Joint DisordersMtor
Testicular NeoplasmsCdkn1b
THROMBOCYTOPENIA 6Src
ThrombosisPik3cb
Thyroid Cancer, FollicularPten
Thyroid NeoplasmsCdkn1a , Pten
Tongue NeoplasmsCdkn1a
Tumor Predisposition SyndromePten
Ureteral ObstructionAkt1 , Mtor
Urinary Bladder NeoplasmsAkt1 , Casp9 , Cdkn1a , Cdkn1b , Mtor , Pten , Sfn , Src
Uterine Cervical NeoplasmsAkt1 , Cdkn1a , Cdkn1b , Mtor , Pik3ca , Pten
Uterine NeoplasmsCdkn1b
VACTERL/VATER Association with HydrocephalusPten
VaricoceleCasp9
Ventilator-Induced Lung InjuryAkt1 , Map3k5
Ventricular RemodelingMap3k5
Vulvar NeoplasmsSfn
Weight GainPik3ca
Wilms TumorCdkn1b
Pathway Annotations Associated with Genes in the phosphatidylinositol 3-kinase-Akt signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayPrkaca
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Chuk , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayPpp2ca
adenosine signaling pathwayAkt1 , Bad , Chuk , Pdpk1 , Pik3ca
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayPrkaca
aldosterone signaling pathwayHsp90aa1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Sfn
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayRaf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered Reelin signaling pathwaySrc
Alzheimer disease pathwayBad , Casp9 , Gsk3b
amiodarone pharmacodynamics pathwayPrkaca
amlodipine pharmacodynamics pathwayPrkaca
amyotrophic lateral sclerosis disease pathwayBad , Casp9
androgen signaling pathwayHsp90aa1
angiotensin II signaling pathwayPdpk1
antigen processing and presentation pathwayHsp90aa1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca
ataxia telangiectasia-mutated (ATM) signaling pathwayPpp2ca
atenolol pharmacodynamics pathwayPrkaca
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Gsk3b , Inpp5d , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
basal cell carcinoma pathwayGsk3b
betaxolol pharmacodynamics pathwayPrkaca
bile acid transport pathwayPrkaca
bisoprolol pharmacodynamics pathwayPrkaca
bladder cancer pathwayCdkn1a , Raf1
Bone morphogenetic proteins signaling pathwayGsk3b
bupranolol drug pathwayPrkaca
bupranolol pharmacodynamics pathwayPrkaca
calcium/calcium-mediated signaling pathwayPrkaca
calcium/calmodulin dependent kinase 2 signaling pathwayPpp2ca
carvedilol pharmacodynamics pathwayPrkaca
cell cycle pathway, mitoticCdkn1a , Cdkn1b , Gsk3b , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
chaperone mediated autophagy pathwayHsp90aa1
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Foxo3 , Gsk3a , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca , Raf1
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Cdkn1b , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
cortisol signaling pathwayHsp90aa1
dilated cardiomyopathy pathwayPrkaca
diltiazem pharmacodynamics pathwayPrkaca
disopyramide pharmacodynamics pathwayPrkaca
dobutamine pharmacodynamics pathwayPrkaca
dopamine signaling pathwayPpp2ca , Ppp2cb , Prkaca , Src
E-cadherin signaling pathwayAkt1 , Akt2 , Pik3ca , Pik3r1 , Src
eicosanoid signaling pathwayAkt1 , Prkaca , Src
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwaySrc
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Foxo3 , Gsk3b , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
Endoplasmic Reticulum-associated degradation pathwayHsp90aa1
endothelin signaling pathwayAkt1 , Raf1 , Src
Entamoeba histolyca infection pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca
ephrin - ephrin receptor bidirectional signaling axisInppl1 , Pik3ca , Pik3r1 , Src
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Cdkn1b , Gsk3b , Hsp90aa1 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1 , Src
erythropoietin signaling pathwayInpp5d , Pik3r1
esmolol pharmacodynamics pathwayPrkaca
estrogen signaling pathwayHsp90aa1 , Src
facilitative sugar transporter mediated glucose transport pathwaySlc2a4
FasL mediated signaling pathwayAkt1 , Chuk , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Inpp5d , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Inpp5d , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Pdpk1 , Pik3ca , Pik3r1 , Src
flecainde pharmacodynamics pathwayPrkaca
forkhead class A signaling pathwayAkt1 , Cdkn1b
fosphenytoin pharmacodynamics pathwayPrkaca
G1/S transition pathwayCdkn1a , Cdkn1b
glioma pathwayAkt1 , Akt2 , Akt3 , Cdkn1a , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
glutamate signaling pathwayPrkaca
glycogen biosynthetic pathwayGsk3a , Gsk3b
glypican signaling pathwaySrc
gonadotropin-releasing hormone signaling pathwayPrkaca , Raf1 , Src
granulocyte-macrophage colony-stimulating factor signaling pathwayInpp5d , Pik3ca , Pik3r1 , Prkaca , Raf1 , Ywhaz
Hedgehog signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1 , Prkaca
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Chuk , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Ppp2r2a , Raf1
histone modification pathwayYwhaz
Huntington disease pathwayCasp9
hypoxia inducible factor pathwayAkt1
ibutilide pharmacodynamics pathwayPrkaca
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Casp9 , Gsk3b , Kpna1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayInppl1 , Pik3ca , Pik3cb , Pik3cd , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Gsk3b , Sfn , Slc2a4 , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Foxo1 , Foxo3 , Gsk3b , Inpp5d , Mtor , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca , Raf1 , Slc2a4
insulin-like growth factor signaling pathwayAkt1 , Bad , Pdpk1 , Pik3ca , Pik3r1 , Raf1 , Ywhae , Ywhaz
interleukin-1 signaling pathwayChuk , Pik3ca , Pik3r1
interleukin-12 signaling pathwayMtor
interleukin-2 signaling pathwayPik3ca , Pik3r1 , Raf1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayInpp5d , Pik3ca , Pik3r1 , Prkaca , Ywhag , Ywhaz
interleukin-4 signaling pathwayAkt1 , Inpp5d , Mtor , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Foxo1 , Pik3ca , Pik3r1
intrinsic apoptotic pathwayBad , Casp9
isoprenaline pharmacodynamics pathwayPrkaca
isradipine pharmacodynamics pathwayPrkaca
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
levobunolol pharmacodynamics pathwayPrkaca
lidocaine pharmacodynamics pathwayPrkaca
long term depressionGsk3b , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Raf1
long term potentiationPrkaca , Raf1
measles infection pathwayAkt1 , Akt2 , Akt3 , Cdkn1b , Chuk , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
metoprolol pharmacodynamics pathwayPrkaca
mexiletine pharmacodynamics pathwayPrkaca
mitochondrial autophagy pathwaySrc
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Prkaca , Raf1
mRNA decay pathwayPpp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Ppp2r2a
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Mapkap1 , Mlst8 , Mtor , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1 , Rictor , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Raf1 , Src
myocarditis pathwayCasp9
N-cadherin signaling pathwayPik3ca , Pik3r1
nadolol pharmacodynamics pathwayPrkaca
nebivolol pharmacodynamics pathwayPrkaca
nerve growth factor signaling pathwaySrc
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Foxo3 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1 , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
nifedipine pharmacodynamics pathwayPrkaca
nimodipine pharmacodynamics pathwayPrkaca
nisoldipine pharmacodynamics pathwayPrkaca
nitrendipine pharmacodynamics pathwayPrkaca
NOD-like receptor signaling pathwayChuk , Hsp90aa1
non-homologous end joining pathway of double-strand break repairPrkdc
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Foxo3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
Notch signaling pathwayCdkn1a
nuclear factor kappa B signaling pathwayChuk , Pik3ca , Pik3r1 , Src
nuclear factor, erythroid 2 like 2 signaling pathwayCdkn1a , Gsk3a , Gsk3b , Pten
p38 MAPK signaling pathwayMap3k5
p53 signaling pathwayAkt1 , Casp9 , Cdkn1a , Gsk3b , Ppp2ca , Pten , Sfn
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
Parkinson disease pathwayCasp9
penbutolol pharmacodynamics pathwayPrkaca
phenytoin pharmacodynamics pathwayPrkaca
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Hsp90aa1 , Inpp5d , Inppl1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Src
phosphatidylinositol 3-kinase signaling pathwayInpp5d , Inppl1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Cdkn1a , Cdkn1b , Chuk , Foxo1 , Foxo3 , Foxo4 , Gsk3a , Gsk3b , Hsp90aa1 , Inpp5d , Inppl1 , Kpna1 , Map3k5 , Mapkap1 , Mlst8 , Mtor , Pdpk1 , Phlpp1 , Phlpp2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Ppp2r2a , Prkaca , Prkdc , Pten , Raf1 , Rictor , Sfn , Slc2a4 , Src , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
phosphoinositide metabolic pathwayInpp5d , Pik3ca , Pik3cd , Pik3r1 , Pten
pindolol pharmacodynamics pathwayPrkaca
platelet-derived growth factor signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ppp2ca , Ppp2r1a , Pten , Raf1 , Sfn , Src , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
prednisolone pharmacodynamics pathwayHsp90aa1
prednisolone pharmacokinetics pathwayHsp90aa1
prion diseases pathwayPrkaca
procainamide pharmacodynamics pathwayPrkaca
propranolol pharmacodynamics pathwayPrkaca
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Cdkn1a , Cdkn1b , Chuk , Foxo1 , Gsk3b , Hsp90aa1 , Mtor , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
protein kinase A (PKA) signaling pathwayPrkaca
protein kinase C (PKC) signaling pathwayHsp90aa1 , Pdpk1 , Phlpp1 , Phlpp2
quinidine pharmacodynamics pathwayPrkaca
Reelin signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1 , Src
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayChuk
scatter factor/hepatocyte growth factor signaling pathwayPik3r1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Casp9 , Cdkn1b , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten
somatostatin signaling pathwaySrc
sotalol pharmacodynamics pathwayPrkaca
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Src
syndecan signaling pathwayPrkaca , Src
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayRaf1
timolol pharmacodynamics pathwayPrkaca
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Trail mediated signaling pathwayChuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayFoxo1 , Foxo3 , Foxo4 , Pdpk1 , Ppp2ca , Ppp2cb , Ppp2r2a , Ywhae
transforming growth factor-beta superfamily mediated signaling pathwayPpp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Ppp2r2a
tumor necrosis factor mediated signaling pathwayChuk , Map3k5
type 2 diabetes mellitus pathwayAkt2 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Slc2a4
type II interferon signaling pathwayAkt1 , Mtor , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwaySrc
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Hsp90aa1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca , Raf1 , Src
vasopressin signaling pathway via receptor type 2Prkaca
verapamil pharmacodynamics pathwayPrkaca
vinblastine pharmacodynamics pathwayCdkn1a
vincristine pharmacodynamics pathwayCdkn1a
vindesine pharmacodynamics pathwayCdkn1a
vinorelbine pharmacodynamics pathwayCdkn1a
Wnt signaling pathwayGsk3b , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Prkaca
Wnt signaling, canonical pathwayGsk3a , Gsk3b
Phenotype Annotations Associated with Genes in the phosphatidylinositol 3-kinase-Akt signaling pathway
Phenotype TermsGene Symbols
neurodegenerationGsk3b

References Associated with the phosphatidylinositol 3-kinase-Akt signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: