JAK-STAT SIGNALING PATHWAY (PW:0000209)

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Description

Jak-Stat pathway is a main intracellular cascade initiated in response to cytokine signaling. In mammals, four Janus kinases (JAK) and seven Stat family members mediate the action of almost 40 cytokines receptors including the receptor for leptin. While leptin is not a cytokine, its receptor bears structural similarity to class I cytokine receptor family. In addition, other receptors through their interactions with members of the Jak family, may trigger the Jak-Stat cascade. In the current model

Pathway Diagram:

Ariadne Genomics Inc. phosphatases ---| Stat members phosphatases ---| Jak members Jak members --+> Stat members Jak members --+> leptin, cytokines, other receptors leptin, cytokines, other receptors --+> Jak members Pias members translocated Stat phosphatases Stat target genes Jak members Socs members Stat members leptin, cytokines, other receptors translocated Stat ---> Stat target genes Pias members ---| translocated Stat translocated Stat ---> Socs members Jak members ---- leptin, cytokines, other receptors leptin, cytokines, other receptors ---- Stat members Stat members ---> translocated Stat Socs members ---| leptin, cytokines, other receptors Socs members ---| Jak members PYs
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Genes in Pathway:

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Jak-Stat signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6907045
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:6907045
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:6907045
G Cblc Cbl proto-oncogene C JBrowse link 1 80,699,321 80,716,146 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Ccnd2 cyclin D2 JBrowse link 4 159,674,885 159,697,207 RGD:6907045
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:6907045
G Cish cytokine inducible SH2-containing protein JBrowse link 8 116,054,547 116,059,494 RGD:6907045
G Clcf1 cardiotrophin-like cytokine factor 1 JBrowse link 1 219,468,866 219,472,445 RGD:6907045
G Cntf ciliary neurotrophic factor JBrowse link 1 229,599,009 229,601,032 RGD:6907045
G Cntfr ciliary neurotrophic factor receptor JBrowse link 5 58,041,114 58,078,687 RGD:6907045
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6907045
G Crlf2 cytokine receptor-like factor 2 JBrowse link 14 1,456,843 1,461,543 RGD:6907045
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6907045
G Csf2ra colony stimulating factor 2 receptor alpha subunit JBrowse link 14 1,462,292 1,467,264 RGD:6907045
G Csf2rb colony stimulating factor 2 receptor beta common subunit JBrowse link 7 119,554,383 119,568,248 RGD:6907045
G Csf3 colony stimulating factor 3 JBrowse link 10 86,616,785 86,619,160 RGD:6907045
G Csf3r colony stimulating factor 3 receptor JBrowse link 5 144,031,353 144,051,966 RGD:6907045
G Ctf1 cardiotrophin 1 JBrowse link 1 199,162,319 199,168,296 RGD:6907045
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6907045
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:6907045
G Epor erythropoietin receptor JBrowse link 8 22,969,737 22,974,468 RGD:6907045
G Gh1 growth hormone 1 JBrowse link 10 94,486,204 94,488,181 RGD:6907045
G Ghr growth hormone receptor JBrowse link 2 53,149,225 53,413,954 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Ifna1 interferon, alpha 1 JBrowse link 5 106,951,822 106,952,908 RGD:6907045
G Ifna11 interferon alpha family, gene 11 JBrowse link 5 107,504,741 107,505,783 RGD:6907045
G Ifna2 interferon alpha 2 JBrowse link 5 107,416,117 107,416,695 RGD:6907045
G Ifna4 interferon, alpha 4 JBrowse link 5 106,922,563 106,923,132 RGD:6907045
G Ifna5 interferon, alpha 5 JBrowse link 5 107,039,347 107,039,925 RGD:6907045
G Ifnar1 interferon alpha and beta receptor subunit 1 JBrowse link 11 31,640,407 31,666,839 RGD:6907045
G Ifnb1 interferon beta 1 JBrowse link 5 106,865,192 106,865,746 RGD:6907045
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6907045
G Ifngr1 interferon gamma receptor 1 JBrowse link 1 15,062,380 15,080,815 RGD:6907045
G Ifngr2 interferon gamma receptor 2 JBrowse link 11 31,694,339 31,712,611 RGD:6907045
G Ifnk interferon kappa JBrowse link 5 50,631,217 50,634,142 RGD:6907045
G Ifnl3 interferon, lambda 3 JBrowse link 1 85,236,243 85,237,775 RGD:6907045
G Ifnlr1 interferon, lambda receptor 1 JBrowse link 5 154,037,243 154,058,862 RGD:6907045
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6907045
G Il10ra interleukin 10 receptor subunit alpha JBrowse link 8 49,558,062 49,573,891 RGD:6907045
G Il10rb interleukin 10 receptor subunit beta JBrowse link 11 31,560,301 31,582,457 RGD:6907045
G Il11 interleukin 11 JBrowse link 1 72,636,959 72,643,255 RGD:6907045
G Il11ra1 interleukin 11 receptor subunit alpha 1 JBrowse link 5 58,149,150 58,159,072 RGD:6907045
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:6907045
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6907045
G Il12rb1 interleukin 12 receptor subunit beta 1 JBrowse link 16 20,370,722 20,383,576 RGD:6907045
G Il12rb2 interleukin 12 receptor subunit beta 2 JBrowse link 4 98,049,195 98,141,562 RGD:6907045
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6907045
G Il13ra1 interleukin 13 receptor subunit alpha 1 JBrowse link X 122,724,081 122,783,801 RGD:6907045
G Il13ra2 interleukin 13 receptor subunit alpha 2 JBrowse link X 118,443,955 118,514,716 RGD:6907045
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:5024920
RGD:6907045
G Il15ra interleukin 15 receptor subunit alpha JBrowse link 17 70,451,861 70,481,838 RGD:5001122
G Il19 interleukin 19 JBrowse link 13 47,663,592 47,677,869 RGD:6907045
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6907045
G Il20 interleukin 20 JBrowse link 13 47,644,071 47,651,487 RGD:6907045
G Il20ra interleukin 20 receptor subunit alpha JBrowse link 1 15,180,328 15,222,785 RGD:6907045
G Il20rb interleukin 20 receptor subunit beta JBrowse link 8 108,745,906 108,778,561 RGD:6907045
G Il21 interleukin 21 JBrowse link 2 123,965,021 123,972,356 RGD:6907045
G Il21r interleukin 21 receptor JBrowse link 1 196,996,405 197,024,185 RGD:6907045
G Il22 interleukin 22 JBrowse link 7 61,236,037 61,240,502 RGD:6907045
G Il22ra1 interleukin 22 receptor subunit alpha 1 JBrowse link 5 154,078,093 154,102,903 RGD:6907045
G Il22ra2 interleukin 22 receptor subunit alpha 2 JBrowse link 1 15,084,136 15,107,423 RGD:6907045
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:6907045
G Il23r interleukin 23 receptor JBrowse link 4 98,203,788 98,306,729 RGD:6907045
G Il24 interleukin 24 JBrowse link 13 47,618,451 47,623,849 RGD:6907045
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:6907045
G Il2rb interleukin 2 receptor subunit beta JBrowse link 7 119,701,338 119,716,238 RGD:6907045
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:6907045
G Il3 interleukin 3 JBrowse link 10 39,620,535 39,622,973 RGD:6907045
G Il3ra interleukin 3 receptor subunit alpha JBrowse link 12 18,534,762 18,542,508 RGD:6907045
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6907045
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:6907045
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6907045
G Il5ra interleukin 5 receptor subunit alpha JBrowse link 4 138,796,165 138,834,164 RGD:6907045
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6907045
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:6907045
G Il6st interleukin 6 signal transducer JBrowse link 2 44,279,199 44,319,427 RGD:6907045
G Il7 interleukin 7 JBrowse link 2 96,427,884 96,474,979 RGD:6907045
G Il7r interleukin 7 receptor RGD:6907045
G Il9 interleukin 9 JBrowse link 17 8,558,827 8,561,950 RGD:6907045
G Il9r interleukin 9 receptor JBrowse link 10 15,697,216 15,708,684 RGD:6907045
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:5128774
G Irf9 interferon regulatory factor 9 JBrowse link 15 34,282,936 34,288,981 RGD:6907045
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:1299183
RGD:6907045
RGD:1625126
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:6907045
RGD:1625126
RGD:1624963
RGD:632386
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:729028
RGD:6907045
RGD:1625126
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6907045
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6907045
G Lif LIF, interleukin 6 family cytokine JBrowse link 14 84,482,652 84,500,574 RGD:6907045
G Lifr LIF receptor alpha JBrowse link 2 56,424,910 56,489,346 RGD:6907045
G LOC100911527 interferon alpha-12-like JBrowse link 5 87,328,395 87,328,946 RGD:6907045
G Mpl MPL proto-oncogene, thrombopoietin receptor JBrowse link 5 137,268,412 137,282,032 RGD:6907045
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6907045
G Osm oncostatin M JBrowse link 14 84,457,487 84,469,426 RGD:6907045
G Osmr oncostatin M receptor JBrowse link 2 56,107,491 56,163,522 RGD:6907045
G Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:1357941
RGD:6907045
RGD:2290530
G Pias2 protein inhibitor of activated STAT, 2 JBrowse link 18 73,479,863 73,524,956 RGD:2290530
RGD:6907045
G Pias3 protein inhibitor of activated STAT, 3 JBrowse link 2 198,821,377 198,831,533 RGD:1357941
RGD:6907045
RGD:2290530
G Pias4 protein inhibitor of activated STAT, 4 JBrowse link 7 11,414,565 11,428,090 RGD:1357941
RGD:6907045
RGD:2290530
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 20 8,165,423 8,169,557 RGD:6907045
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6907045
G Prlr prolactin receptor JBrowse link 2 60,131,410 60,325,686 RGD:6907045
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:633057
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:2290530
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:2290530
RGD:6907045
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:2290530
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:2290530
RGD:6907045
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:1357935
RGD:6907045
G Socs2 suppressor of cytokine signaling 2 JBrowse link 7 36,495,496 36,500,878 RGD:1357935
RGD:6907045
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:1357935
RGD:6907045
G Socs4 suppressor of cytokine signaling 4 JBrowse link 15 24,056,383 24,070,868 RGD:1357941
RGD:6907045
G Socs5 suppressor of cytokine signaling 5 JBrowse link 6 10,671,311 10,705,610 RGD:1357941
RGD:6907045
G Socs6 suppressor of cytokine signaling 6 JBrowse link 18 85,962,729 85,981,125 RGD:1357941
G Socs7 suppressor of cytokine signaling 7 JBrowse link 10 85,301,797 85,337,971 RGD:1357941
RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Spred1 sprouty-related, EVH1 domain containing 1 JBrowse link 3 108,795,337 108,861,650 RGD:6907045
G Spred2 sprouty-related, EVH1 domain containing 2 JBrowse link 14 104,268,362 104,290,206 RGD:6907045
G Spred3 sprouty-related, EVH1 domain containing 3 JBrowse link 1 88,101,213 88,112,719 RGD:6907045
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 15 90,172,769 90,177,823 RGD:6907045
G Spry3 sprouty RTK signaling antagonist 3 JBrowse link 12 18,930,087 18,940,622 RGD:6907045
G Spry4 sprouty RTK signaling antagonist 4 JBrowse link 18 32,593,370 32,609,890 RGD:6907045
G Stam signal transducing adaptor molecule JBrowse link 17 81,209,795 81,256,111 RGD:6907045
G Stam2 signal transducing adaptor molecule 2 JBrowse link 3 38,230,676 38,277,433 RGD:6907045
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:1299060
RGD:6907045
RGD:1625126
G Stat2 signal transducer and activator of transcription 2 JBrowse link 7 2,691,064 2,707,530 RGD:1357935
RGD:6907045
RGD:1625126
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:1299183
RGD:6907045
RGD:1625126
G Stat4 signal transducer and activator of transcription 4 JBrowse link 9 54,340,649 54,457,753 RGD:1357935
RGD:6907045
RGD:1625126
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:1357935
RGD:6907045
RGD:1625126
RGD:1624963
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:628356
RGD:6907045
RGD:1625126
RGD:1624963
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:1357935
RGD:6907045
RGD:1625126
G Tpo thyroid peroxidase JBrowse link 6 49,020,918 49,089,855 RGD:6907045
G Tslp thymic stromal lymphopoietin JBrowse link 18 25,613,601 25,618,066 RGD:6907045
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:1357935
RGD:1625126
altered Jak-Stat signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1357939
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1357939

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassJak membersJanus-activated kinase
Gene GroupStat target genesList of selected target genes
Functional ClassPiasproteins that inhibit activated STATs
Functional ClassStat memberssignal transducers and activators of transcription
Functional ClassSocs memberssuppressors of cytokine signaling
Functional Classphosphatasestyrosine phosphatases involved in the regulation of Kaj-Stat pathway

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the Jak-Stat signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pim1 , Sos1 , Sos2 , Stat3 , Stat5a , Stat5b
adenosine signaling pathwayAkt1 , Pik3ca
aldosterone signaling pathwayCrebbp , Jak2 , Pias1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
allograft rejection pathwayIfng , Il10 , Il12a , Il12b , Il2 , Il4 , Il5
altered energy homeostasis pathwayLep , Lepr
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered Jak-Stat signaling pathwayJak2 , Jak3
altered leptin system pathwayLep , Lepr
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
amyotrophic lateral sclerosis disease pathwayBcl2l1
androgen signaling pathwayCrebbp , Ep300 , Pias2
angiotensin II signaling pathwayJak2
angiotensin II signaling pathway via AT1 receptorJak2 , Tyk2
angiotensin II signaling pathway via AT2 receptorPtpn6
antigen processing and presentation pathwayIfng
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Csf2rb , Il3 , Il3ra , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
asthma disease pathwayIl10 , Il13 , Il3 , Il4 , Il5 , Il9
ataxia telangiectasia-mutated (ATM) signaling pathwayPias1 , Pias4
autoimmune thyroid disease pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Il10 , Il2 , Il4 , Il5 , LOC100911527 , Tpo
autophagy pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , LOC100911527
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn6 , Sos1 , Sos2
bladder cancer pathwayCcnd1 , Myc
brain-derived neurotrophic factor signaling pathwayGrb2
calcium/calcium-mediated signaling pathwayPtk2b
cell cycle pathway, mitoticCcnd1 , Ccnd2 , Ccnd3 , Crebbp , Ep300 , Myc
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Ccnd1 , Jak1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Jak2 , Jak3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptk2b , Sos1 , Sos2 , Stat1 , Stat2 , Stat3 , Stat5b
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Cbl , Cblb , Cblc , Ccnd1 , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Sos1 , Sos2 , Stat5a , Stat5b
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
cortisol signaling pathwayCrebbp , Ep300
cytokine mediated signaling pathwayClcf1 , Cntf , Cntfr , Crlf2 , Csf2 , Csf2ra , Csf2rb , Csf3 , Csf3r , Ctf1 , Epo , Epor , Ghr , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ifng , Ifngr1 , Ifngr2 , Ifnk , Ifnlr1 , Il10 , Il10ra , Il10rb , Il11 , Il11ra1 , Il12a , Il12b , Il12rb1 , Il12rb2 , Il13 , Il13ra1 , Il15 , Il2 , Il20ra , Il20rb , Il21 , Il21r , Il22 , Il22ra1 , Il22ra2 , Il23a , Il23r , Il2ra , Il2rb , Il2rg , Il3 , Il3ra , Il4 , Il4r , Il5 , Il5ra , Il6 , Il6r , Il6st , Il7 , Il7r , Il9 , Il9r , Lep , Lepr , Lif , Lifr , LOC100911527 , Mpl , Osm , Osmr , Prl , Prlr , Tpo , Tslp
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Pik3ca , Pik3r1
eicosanoid signaling pathwayAkt1 , Pik3r5
endocytosis pathwayCbl , Cblb , Cblc , Il2ra , Il2rb , Il2rg , Stam , Stam2
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
endothelin signaling pathwayAkt1 , Jak2 , Ptk2b
energy homeostasis pathwayLep , Lepr
Entamoeba histolyca infection pathwayCsf2 , Ifng , Il10 , Il12a , Il12b , Il6 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
ephrin - ephrin receptor bidirectional signaling axisCbl , Grb2 , Pik3ca , Pik3r1 , Pik3r5
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn1 , Ptpn11 , Ptpn6 , Sos1 , Sos2 , Stat1 , Stat3 , Stat5a , Stat5b
erythropoietin signaling pathwayBcl2l1 , Cbl , Epo , Epor , Grb2 , Jak2 , Pik3r1 , Ptpn11 , Ptpn6 , Socs3 , Sos1 , Stat1 , Stat5a , Stat5b
estrogen signaling pathwayCrebbp , Ep300
FasL mediated signaling pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Csf2 , Grb2 , Il13 , Il3 , Il4 , Il5 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
fibroblast growth factor signaling pathwayAkt1 , Cbl , Grb2 , Pik3ca , Pik3r1 , Ptk2b , Ptpn11 , Sos1 , Spry2 , Stat1 , Stat5b
forkhead class A signaling pathwayAkt1 , Crebbp , Ep300
G1 phase pathwayCcnd1
G1/S transition pathwayCcnd1 , Ccnd2 , Ccnd3
glioma pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
gonadotropin-releasing hormone signaling pathwayGrb2 , Ptk2b , Sos1 , Sos2
graft-versus-host disease pathwayIfng , Il2 , Il6
granulocyte-macrophage colony-stimulating factor signaling pathwayCish , Csf2 , Csf2rb , Grb2 , Jak2 , Osm , Pik3ca , Pik3r1 , Pim1 , Ptpn11 , Sos1 , Stat1 , Stat3 , Stat5a , Stat5b
growth hormone signaling pathwayGhr , Jak2
Hedgehog signaling pathwayAkt1 , Crebbp , Pias1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Grb2 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Irf1 , Irf9 , Jak1 , LOC100911527 , Pias1 , Pias2 , Pias3 , Pias4 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs3 , Sos1 , Sos2 , Stat1 , Stat2 , Stat3
histone modification pathwayCrebbp , Ep300
Huntington disease pathwayCrebbp , Ep300
hypertrophic cardiomyopathy pathwayIl6
hypoxia inducible factor pathwayAkt1 , Crebbp , Ep300 , Epo , Lep
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Crebbp , Ep300 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ifng , Ifngr1 , Ifngr2 , Il12a , Il12b , Il6 , Irf9 , Jak1 , Jak2 , LOC100911527 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs3 , Stat1 , Stat2
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Cbl
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn1 , Ptpn11 , Socs1 , Socs2 , Socs3 , Socs4 , Socs6 , Socs7 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1 , Ptpn1 , Ptpn11 , Sos1
interleukin-1 signaling pathwayPik3ca , Pik3r1
Interleukin-10 signaling pathwayIl10 , Il10ra , Il10rb , Jak1 , Stat1 , Stat3 , Tyk2
interleukin-12 signaling pathwayIfng , Il12a , Il12b , Il12rb1 , Il12rb2 , Il2 , Il2ra , Il2rb , Il2rg , Il4 , Jak2 , Socs1 , Stat1 , Stat3 , Stat4 , Stat5a , Stat6 , Tyk2
interleukin-2 signaling pathwayCish , Grb2 , Ifng , Il2 , Il2ra , Il2rb , Il2rg , Jak1 , Jak3 , Myc , Pik3ca , Pik3r1 , Ptk2b , Ptpn11 , Socs1 , Socs2 , Socs3 , Sos1 , Stam , Stam2 , Stat1 , Stat3 , Stat5a , Stat5b
interleukin-23 signaling pathwayIfng , Il12b , Il12rb1 , Il19 , Il2 , Il23a , Il23r , Il24 , Il6 , Jak2 , Pik3ca , Pik3r1 , Socs3 , Stat1 , Stat3 , Stat4 , Stat5a , Tyk2
interleukin-27 signaling pathwayIfng , Il12a , Il12b , Il12rb1 , Il12rb2 , Il2 , Il6 , Il6st , Jak1 , Jak2 , Stat1 , Stat2 , Stat3 , Stat4 , Stat5a , Tyk2
interleukin-3 signaling pathwayBcl2l1 , Cish , Csf2rb , Grb2 , Il3 , Il3ra , Jak2 , Osm , Pik3ca , Pik3r1 , Pim1 , Ptpn11 , Stat5a , Stat5b
interleukin-4 signaling pathwayAkt1 , Cbl , Grb2 , Il10 , Il13ra2 , Il2rg , Il4 , Il4r , Il5 , Jak1 , Jak2 , Jak3 , Pik3ca , Pik3r1 , Ptpn6 , Socs1 , Socs3 , Socs5 , Stat5a , Stat5b , Stat6
interleukin-5 signaling pathwayCish , Csf2rb , Grb2 , Il5 , Il5ra , Jak2 , Pik3ca , Pik3r1 , Pim1 , Ptpn11 , Stat5a , Stat5b
interleukin-6 signaling pathwayAkt1 , Grb2 , Il6 , Il6r , Il6st , Irf1 , Jak1 , Jak2 , Myc , Pias1 , Pias3 , Pik3ca , Pik3r1 , Ptpn11 , Socs3 , Sos1 , Sos2 , Stat1 , Stat3 , Tyk2
intrinsic apoptotic pathwayBcl2l1
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Cbl , Cblb , Cblc , Ccnd1 , Ccnd2 , Ccnd3 , Cish , Clcf1 , Cntf , Cntfr , Crebbp , Crlf2 , Csf2 , Csf2ra , Csf2rb , Csf3 , Csf3r , Ctf1 , Ep300 , Epo , Epor , Gh1 , Ghr , Grb2 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ifng , Ifngr1 , Ifngr2 , Ifnk , Ifnl3 , Ifnlr1 , Il10 , Il10ra , Il10rb , Il11 , Il11ra1 , Il12a , Il12b , Il12rb1 , Il12rb2 , Il13 , Il13ra1 , Il13ra2 , Il15 , Il15ra , Il19 , Il2 , Il20 , Il20ra , Il20rb , Il21 , Il21r , Il22 , Il22ra1 , Il22ra2 , Il23a , Il23r , Il24 , Il2ra , Il2rb , Il2rg , Il3 , Il3ra , Il4 , Il4r , Il5 , Il5ra , Il6 , Il6r , Il6st , Il7 , Il7r , Il9 , Il9r , Irf1 , Irf9 , Jak1 , Jak2 , Jak3 , Lep , Lepr , Lif , Lifr , LOC100911527 , Mpl , Myc , Osm , Osmr , Pias1 , Pias2 , Pias3 , Pias4 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pim1 , Prl , Prlr , Ptk2b , Ptpn1 , Ptpn11 , Ptpn2 , Ptpn6 , Socs1 , Socs2 , Socs3 , Socs4 , Socs5 , Socs6 , Socs7 , Sos1 , Sos2 , Spred1 , Spred2 , Spred3 , Spry2 , Spry3 , Spry4 , Stam , Stam2 , Stat1 , Stat2 , Stat3 , Stat4 , Stat5a , Stat5b , Stat6 , Tpo , Tslp , Tyk2
Leishmania infection pathwayIfng , Ifngr1 , Ifngr2 , Il10 , Il12a , Il12b , Il4 , Jak1 , Jak2 , Ptpn6 , Stat1
leptin system pathwayJak2 , Lep , Lepr , Ptpn1 , Ptpn11 , Socs3 , Stat3
long term potentiationCrebbp , Ep300
measles infection pathwayAkt1 , Akt2 , Akt3 , Cblb , Ccnd1 , Ccnd2 , Ccnd3 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ifng , Ifngr1 , Ifngr2 , Il12a , Il12b , Il13 , Il2 , Il2ra , Il2rb , Il2rg , Il4 , Il6 , Irf9 , Jak1 , Jak2 , Jak3 , LOC100911527 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat2 , Stat3 , Stat5a , Stat5b
melanoma pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Myc , Sos1 , Sos2
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Crebbp , Ep300 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnb1 , Ifng , Ifngr1 , Ifngr2 , Il10 , Il10ra , Il10rb , Il12a , Il12b , Il23a , Il6 , Jak1 , Jak2 , LOC100911527 , Stat1
myocarditis pathwayCcnd1
N-cadherin signaling pathwayPik3ca , Pik3r1 , Ptpn1 , Ptpn11
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Sos1 , Sos2
NOD-like receptor signaling pathwayIl6
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Non-Stat, Jak dependent pathwayJak1 , Tyk2
Notch signaling pathwayCbl , Ccnd1 , Crebbp , Ep300 , Il4 , Myc
nuclear factor kappa B signaling pathwayIrf1 , Pik3ca , Pik3r1
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp
obesity disease pathwayLepr
p38 MAPK signaling pathwayIrf1
p53 signaling pathwayAkt1 , Ccnd1 , Ccnd2 , Ccnd3 , Crebbp , Ep300
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Ccnd1 , Jak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
Plasmodium infection pathwayCsf3 , Ifng , Il10 , Il12a , Il6
platelet-derived growth factor signaling pathwayCbl , Grb2 , Ifng , Jak1 , Jak2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn1 , Ptpn11 , Sos1 , Stat1 , Stat3 , Stat5a , Stat5b
primary immunodeficiency disease pathwayIl2rg , Il7r , Jak3
prion diseases pathwayIl6
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Crebbp , Ep300 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Ras family mediated signaling pathwaySos1
Reelin signaling pathwayAkt1 , Cbl , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Crebbp , Ep300 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Sos1 , Sos2
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnb1 , Ifnk , Il12a , Il12b , LOC100911527
rheumatoid arthritis disease pathwayCsf2 , Ifng , Il11 , Il15 , Il23a , Il6
Rho/Rac/Cdc42 mediated signaling pathwayCbl , Ptk2b
RNA polymerase I transcription pathwayCrebbp
S phase pathwayCcnd1
scatter factor/hepatocyte growth factor signaling pathwayCbl , Grb2 , Pik3r1 , Ptpn11
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Ccnd1 , Myc , Pias1 , Pias2 , Pias3 , Pias4 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
somatostatin signaling pathwayJak2 , Ptpn11
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Jak2
Staphylococcus aureus infection pathwayIl10
sumoylation pathwayPias3
syndecan signaling pathwayCsf2
systemic lupus erythematosus pathwayIfng , Il10
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Csf2 , Grb2 , Ifng , Il10 , Il2 , Il4 , Il5 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn6 , Sos1 , Sos2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayPtk2b
thyroid cancer pathwayCcnd1 , Myc
thyroid hormone biosynthetic pathwayTpo
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Il12a , Il12b , Il6 , LOC100911527 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Ifng , Ifngr1 , Ifngr2 , Il10 , Il10ra , Il10rb , Il12a , Il12b , Jak1 , Jak2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs1 , Stat1 , Stat3
Trail mediated signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayCrebbp , Grb2 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Ep300 , Ifng , Myc
Trypanosoma brucei infection pathwayIfng , Il10 , Il12a , Il12b , Il6
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Ifnb1 , Ifng , Ifngr1 , Ifngr2 , Il10 , Il12a , Il12b , Il2 , Il6 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
tumor necrosis factor mediated signaling pathwayStat1
type 1 diabetes mellitus pathwayIfng , Il12a , Il12b , Il2
type 2 diabetes mellitus pathwayAkt2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs1 , Socs2 , Socs3 , Socs4
type II interferon signaling pathwayAkt1 , Cbl , Crebbp , Ep300 , Ifng , Ifngr1 , Irf1 , Irf9 , Jak1 , Jak2 , Pias1 , Pias4 , Pik3ca , Pik3r1 , Ptpn11 , Socs1 , Stat1 , Stat3
tyrosine metabolic pathwayTpo
ubiquitin/proteasome degradation pathwayCbl , Cblb , Cblc , Ifng , Pias1 , Pias2 , Pias3 , Pias4 , Socs1 , Socs3
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptk2b , Ptpn11 , Ptpn6
Wnt signaling pathwayCcnd1 , Ccnd2 , Ccnd3 , Crebbp , Ep300 , Myc
Wnt signaling, canonical pathwayCrebbp
Phenotype Annotations Associated with Genes in the Jak-Stat signaling pathway

References Associated with the Jak-Stat signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: