JAK-STAT SIGNALING PATHWAY (PW:0000209)

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Description

Jak-Stat pathway is a main intracellular cascade initiated in response to cytokine signaling. In mammals, four Janus kinases (JAK) and seven Stat family members mediate the action of almost 40 cytokines receptors including the receptor for leptin. While leptin is not a cytokine, its receptor bears structural similarity to class I cytokine receptor family. In addition, other receptors through their interactions with members of the Jak family, may trigger the Jak-Stat cascade. In the current model

Pathway Diagram:

Ariadne Genomics Inc. phosphatases ---| Stat members phosphatases ---| Jak members Jak members --+> Stat members Jak members --+> leptin, cytokines, other receptors leptin, cytokines, other receptors --+> Jak members Pias members translocated Stat phosphatases Stat target genes Jak members Socs members Stat members leptin, cytokines, other receptors translocated Stat ---> Stat target genes Pias members ---| translocated Stat translocated Stat ---> Socs members Jak members ---- leptin, cytokines, other receptors leptin, cytokines, other receptors ---- Stat members Stat members ---> translocated Stat Socs members ---| leptin, cytokines, other receptors Socs members ---| Jak members PYs
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Genes in Pathway:

show annotations for term's descendants       view all columns
Jak-Stat signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6907045
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:6907045
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:6907045
G Cblc Cbl proto-oncogene C JBrowse link 1 80,699,321 80,716,146 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Ccnd2 cyclin D2 JBrowse link 4 159,674,885 159,697,207 RGD:6907045
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:6907045
G Cish cytokine inducible SH2-containing protein JBrowse link 8 116,054,547 116,059,494 RGD:6907045
G Clcf1 cardiotrophin-like cytokine factor 1 JBrowse link 1 219,468,866 219,472,445 RGD:6907045
G Cntf ciliary neurotrophic factor JBrowse link 1 229,599,009 229,601,032 RGD:6907045
G Cntfr ciliary neurotrophic factor receptor JBrowse link 5 58,041,114 58,078,687 RGD:6907045
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6907045
G Crlf2 cytokine receptor-like factor 2 JBrowse link 14 1,456,843 1,461,543 RGD:6907045
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6907045
G Csf2ra colony stimulating factor 2 receptor alpha subunit JBrowse link 14 1,462,292 1,467,264 RGD:6907045
G Csf2rb colony stimulating factor 2 receptor beta common subunit JBrowse link 7 119,554,383 119,568,248 RGD:6907045
G Csf3 colony stimulating factor 3 JBrowse link 10 86,616,785 86,619,160 RGD:6907045
G Csf3r colony stimulating factor 3 receptor JBrowse link 5 144,031,353 144,051,966 RGD:6907045
G Ctf1 cardiotrophin 1 JBrowse link 1 199,162,319 199,168,296 RGD:6907045
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6907045
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:6907045
G Epor erythropoietin receptor JBrowse link 8 22,969,737 22,974,468 RGD:6907045
G Gh1 growth hormone 1 JBrowse link 10 94,486,204 94,488,181 RGD:6907045
G Ghr growth hormone receptor JBrowse link 2 53,149,225 53,413,954 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Ifna1 interferon, alpha 1 JBrowse link 5 106,951,822 106,952,908 RGD:6907045
G Ifna11 interferon alpha family, gene 11 JBrowse link 5 107,504,741 107,505,783 RGD:6907045
G Ifna2 interferon alpha 2 JBrowse link 5 107,416,117 107,416,695 RGD:6907045
G Ifna4 interferon, alpha 4 JBrowse link 5 106,922,563 106,923,132 RGD:6907045
G Ifna5 interferon, alpha 5 JBrowse link 5 107,039,347 107,039,925 RGD:6907045
G Ifnar1 interferon alpha and beta receptor subunit 1 JBrowse link 11 31,640,407 31,666,839 RGD:6907045
G Ifnb1 interferon beta 1 JBrowse link 5 106,865,192 106,865,746 RGD:6907045
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6907045
G Ifngr1 interferon gamma receptor 1 JBrowse link 1 15,062,380 15,080,815 RGD:6907045
G Ifngr2 interferon gamma receptor 2 JBrowse link 11 31,694,339 31,712,611 RGD:6907045
G Ifnk interferon kappa JBrowse link 5 50,631,217 50,634,142 RGD:6907045
G Ifnl3 interferon, lambda 3 JBrowse link 1 85,236,243 85,237,775 RGD:6907045
G Ifnlr1 interferon, lambda receptor 1 JBrowse link 5 154,037,243 154,058,862 RGD:6907045
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6907045
G Il10ra interleukin 10 receptor subunit alpha JBrowse link 8 49,558,062 49,573,891 RGD:6907045
G Il10rb interleukin 10 receptor subunit beta JBrowse link 11 31,560,301 31,582,457 RGD:6907045
G Il11 interleukin 11 JBrowse link 1 72,636,959 72,643,255 RGD:6907045
G Il11ra1 interleukin 11 receptor subunit alpha 1 JBrowse link 5 58,149,150 58,159,072 RGD:6907045
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:6907045
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6907045
G Il12rb1 interleukin 12 receptor subunit beta 1 JBrowse link 16 20,370,722 20,383,576 RGD:6907045
G Il12rb2 interleukin 12 receptor subunit beta 2 JBrowse link 4 98,049,195 98,141,562 RGD:6907045
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6907045
G Il13ra1 interleukin 13 receptor subunit alpha 1 JBrowse link X 122,724,081 122,783,801 RGD:6907045
G Il13ra2 interleukin 13 receptor subunit alpha 2 JBrowse link X 118,443,955 118,514,716 RGD:6907045
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:5024920
RGD:6907045
G Il15ra interleukin 15 receptor subunit alpha JBrowse link 17 70,451,861 70,481,838 RGD:5001122
G Il19 interleukin 19 JBrowse link 13 47,663,592 47,677,869 RGD:6907045
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6907045
G Il20 interleukin 20 JBrowse link 13 47,644,071 47,651,487 RGD:6907045
G Il20ra interleukin 20 receptor subunit alpha JBrowse link 1 15,180,328 15,222,785 RGD:6907045
G Il20rb interleukin 20 receptor subunit beta JBrowse link 8 108,745,906 108,778,561 RGD:6907045
G Il21 interleukin 21 JBrowse link 2 123,965,021 123,972,356 RGD:6907045
G Il21r interleukin 21 receptor JBrowse link 1 196,996,405 197,024,185 RGD:6907045
G Il22 interleukin 22 JBrowse link 7 61,236,037 61,240,502 RGD:6907045
G Il22ra1 interleukin 22 receptor subunit alpha 1 JBrowse link 5 154,078,093 154,102,903 RGD:6907045
G Il22ra2 interleukin 22 receptor subunit alpha 2 JBrowse link 1 15,084,136 15,107,423 RGD:6907045
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:6907045
G Il23r interleukin 23 receptor JBrowse link 4 98,203,788 98,306,729 RGD:6907045
G Il24 interleukin 24 JBrowse link 13 47,618,451 47,623,849 RGD:6907045
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:6907045
G Il2rb interleukin 2 receptor subunit beta JBrowse link 7 119,701,338 119,716,238 RGD:6907045
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:6907045
G Il3 interleukin 3 JBrowse link 10 39,620,535 39,622,973 RGD:6907045
G Il3ra interleukin 3 receptor subunit alpha JBrowse link 12 18,534,762 18,542,508 RGD:6907045
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6907045
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:6907045
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6907045
G Il5ra interleukin 5 receptor subunit alpha JBrowse link 4 138,796,165 138,834,164 RGD:6907045
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6907045
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:6907045
G Il6st interleukin 6 signal transducer JBrowse link 2 44,279,199 44,319,427 RGD:6907045
G Il7 interleukin 7 JBrowse link 2 96,427,884 96,474,979 RGD:6907045
G Il7r interleukin 7 receptor RGD:6907045
G Il9 interleukin 9 JBrowse link 17 8,558,827 8,561,950 RGD:6907045
G Il9r interleukin 9 receptor JBrowse link 10 15,697,216 15,708,684 RGD:6907045
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:5128774
G Irf9 interferon regulatory factor 9 JBrowse link 15 34,282,936 34,288,981 RGD:6907045
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:1299183
RGD:1625126
RGD:6907045
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:632386
RGD:1624963
RGD:1625126
RGD:6907045
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:729028
RGD:1625126
RGD:6907045
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6907045
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6907045
G Lif LIF, interleukin 6 family cytokine JBrowse link 14 84,482,652 84,500,574 RGD:6907045
G Lifr LIF receptor alpha JBrowse link 2 56,424,910 56,489,346 RGD:6907045
G LOC100911527 interferon alpha-12-like JBrowse link 5 87,328,395 87,328,946 RGD:6907045
G Mpl MPL proto-oncogene, thrombopoietin receptor JBrowse link 5 137,268,412 137,282,032 RGD:6907045
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6907045
G Osm oncostatin M JBrowse link 14 84,457,487 84,469,426 RGD:6907045
G Osmr oncostatin M receptor JBrowse link 2 56,107,491 56,163,522 RGD:6907045
G Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:1357941
RGD:2290530
RGD:6907045
G Pias2 protein inhibitor of activated STAT, 2 JBrowse link 18 73,479,863 73,524,956 RGD:2290530
RGD:6907045
G Pias3 protein inhibitor of activated STAT, 3 JBrowse link 2 198,821,377 198,831,533 RGD:1357941
RGD:2290530
RGD:6907045
G Pias4 protein inhibitor of activated STAT, 4 JBrowse link 7 11,414,565 11,428,090 RGD:1357941
RGD:2290530
RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 20 8,165,423 8,169,557 RGD:6907045
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6907045
G Prlr prolactin receptor JBrowse link 2 60,131,410 60,325,686 RGD:6907045
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:633057
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:2290530
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:2290530
RGD:6907045
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:2290530
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:2290530
RGD:6907045
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:1357935
RGD:6907045
G Socs2 suppressor of cytokine signaling 2 JBrowse link 7 36,495,496 36,500,878 RGD:1357935
RGD:6907045
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:1357935
RGD:6907045
G Socs4 suppressor of cytokine signaling 4 JBrowse link 15 24,056,383 24,070,868 RGD:1357941
RGD:6907045
G Socs5 suppressor of cytokine signaling 5 JBrowse link 6 10,671,311 10,705,610 RGD:1357941
RGD:6907045
G Socs6 suppressor of cytokine signaling 6 JBrowse link 18 85,962,729 85,981,125 RGD:1357941
G Socs7 suppressor of cytokine signaling 7 JBrowse link 10 85,301,797 85,337,971 RGD:1357941
RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Spred1 sprouty-related, EVH1 domain containing 1 JBrowse link 3 108,795,337 108,861,650 RGD:6907045
G Spred2 sprouty-related, EVH1 domain containing 2 JBrowse link 14 104,268,362 104,290,206 RGD:6907045
G Spred3 sprouty-related, EVH1 domain containing 3 JBrowse link 1 88,101,213 88,112,719 RGD:6907045
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 15 90,172,769 90,177,823 RGD:6907045
G Spry3 sprouty RTK signaling antagonist 3 JBrowse link 12 18,930,087 18,940,622 RGD:6907045
G Spry4 sprouty RTK signaling antagonist 4 JBrowse link 18 32,593,370 32,609,890 RGD:6907045
G Stam signal transducing adaptor molecule JBrowse link 17 81,209,795 81,256,111 RGD:6907045
G Stam2 signal transducing adaptor molecule 2 JBrowse link 3 38,230,676 38,277,433 RGD:6907045
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:1299060
RGD:1625126
RGD:6907045
G Stat2 signal transducer and activator of transcription 2 JBrowse link 7 2,691,064 2,707,530 RGD:1357935
RGD:1625126
RGD:6907045
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:1299183
RGD:1625126
RGD:6907045
G Stat4 signal transducer and activator of transcription 4 JBrowse link 9 54,340,649 54,457,753 RGD:1357935
RGD:1625126
RGD:6907045
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:1357935
RGD:1624963
RGD:1625126
RGD:6907045
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:628356
RGD:1624963
RGD:1625126
RGD:6907045
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:1357935
RGD:1625126
RGD:6907045
G Tpo thyroid peroxidase JBrowse link 6 49,020,918 49,089,855 RGD:6907045
G Tslp thymic stromal lymphopoietin JBrowse link 18 25,613,601 25,618,066 RGD:6907045
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:1357935
RGD:1625126
altered Jak-Stat signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1357939
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1357939

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassJak membersJanus-activated kinase
Gene GroupStat target genesList of selected target genes
Functional ClassPiasproteins that inhibit activated STATs
Functional ClassStat memberssignal transducers and activators of transcription
Functional ClassSocs memberssuppressors of cytokine signaling
Functional Classphosphatasestyrosine phosphatases involved in the regulation of Kaj-Stat pathway

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Jak-Stat signaling pathway
Disease TermsGene Symbols
2-HydroxyglutaricaciduriaSos2
Abnormalities, MultipleCrebbp , Stat2
Abortion, SpontaneousCsf3 , Il11 , Il12b , Il20ra , Il24 , Il5ra , Il6 , Il9 , Jak2 , Lif , Prlr
Absent Radii and ThrombocytopeniaPias3
Acne VulgarisIl4r
Acquired Immunodeficiency SyndromeIfng , Il2 , Il4r
AcromegalyGh1
Acute Coronary SyndromeIl6
Acute ErythroleukemiaEpor
Acute Kidney InjuryBcl2l1 , Epo , Il10 , Il20 , Il6 , Myc
Acute Lung InjuryIfng , Il10 , Il13 , Il2 , Il22 , Il4 , Il6 , Jak3
Acute-Phase ReactionEpo , Il6 , Il6r , Stat5b
AdenocarcinomaCcnd1 , Myc , Pik3ca , Prl , Ptpn11 , Stat3 , Stat5a
Adenocarcinoma of EsophagusPik3ca
Adenocarcinoma of LungAkt1 , Crebbp , Ep300 , Myc , Pik3ca , Ptpn11 , Sos1
Adenocarcinoma, ColonCsf2
Adenocarcinoma, ColorectalBcl2l1
Adenocarcinoma, ProstaticAkt1 , Pik3ca
AdenomaBcl2l1 , Prl
Adenomatous Polyposis ColiAkt1
Adrenocortical CarcinomaPik3ca
AdrenoleukodystrophyIfng
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Aggressive PeriodontitisIl2
AgranulocytosisCsf2 , Csf3
AIDS Dementia ComplexEpo
Airway ObstructionIl10 , Il9
AlbuminuriaEpo , Il6 , Lepr , Tslp
Alcoholic IntoxicationIfng
Allergic AsthmaIl4r
Alopecia AreataIl2 , Il2ra
Alopecia universalisIl4
Alveolar Bone LossIl10
Alveolitis, Extrinsic AllergicIl13 , Il5
Alzheimer DiseaseAkt1 , Bcl2l1 , Crebbp , Ep300 , Epo , Epor , Il10 , Il2 , Il3 , Il4 , Il6 , Il6r , Il6st , Il7 , Jak2 , Lep , Pik3r1 , Stat3
AmenorrheaPrl
AmnesiaCsf2 , Il2 , Il6
Amphetamine-Related DisordersAkt1
Amyloidosis IXOsmr
Amyotrophic Lateral SclerosisAkt1 , Cntf , Epo
Amyotrophic Lateral Sclerosis 1Bcl2l1 , Cntf , Crebbp , Jak3
AnaphylaxisIl4
Anastomotic LeakEpo
AnemiaCsf2 , Csf3 , Epo , Epor , Gh1 , Il10 , Il2 , Il3 , Il6 , Jak2 , Prl
Anemia, AplasticCsf2 , Csf3 , Ifng
Anemia, Diamond-BlackfanGh1
Anemia, HemolyticEpo
Anemia, Hemolytic, AutoimmuneIl10
Anemia, Iron-DeficiencyIl6
Anemia, Sickle CellIl10 , Il5
Angina, UnstableAkt1
AngiomyolipomaStat1 , Stat3
AngiostrongyliasisIl5
AnorexiaIl2
AnoxiaIl4r , Stat5b
Anti-Glomerular Basement Membrane DiseaseIl10 , Il4 , Ptk2b
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisCsf3
Anus NeoplasmsIfnb1
Aortic Aneurysm, AbdominalCsf2
Aortic Valve Disease 1Il6
Aortic Valve InsufficiencyPtpn11
Aortic Valve StenosisPtpn11
Aortic Valve, Calcification ofAkt1
AppendicitisIfng , Il10
Arrhythmogenic Right Ventricular DysplasiaIl6r
Arsenic PoisoningPias1
ArteriosclerosisIfngr1 , Il10 , Il15 , Il6st , Lepr
ArthralgiaCsf3
ArthritisIl23r
Arthritis, ExperimentalAkt1 , Cbl , Cblb , Csf3 , Ifng , Il10 , Il13 , Il15 , Il2 , Il20 , Il2ra , Il4 , Il6 , Il6st , Jak2 , Jak3 , Lep , Pik3cd , Socs3 , Stat1 , Stat3
Arthritis, InfectiousIfng
Arthritis, JuvenileIl2 , Il6 , Osm , Stat3
Arthritis, PsoriaticIl12b , Il13 , Stat3 , Stat4
Arthritis, RheumatoidCsf2 , Ifng , Il10 , Il13 , Il2 , Il20 , Il21r , Il23a , Il23r , Il2ra , Il2rb , Il3 , Il4r , Il5 , Il6 , Il6r , Il6st , Jak2 , Ptpn2 , Spred2 , Stat1 , Stat3 , Stat4 , Tyk2
Ascorbic Acid DeficiencyIl6
AspergillosisIl15
AstheniaIl2
AsthenopiaIl10
AsthmaCsf2 , Csf2rb , Csf3 , Ifng , Ifngr1 , Ifnl3 , Il10 , Il12a , Il12b , Il13 , Il13ra1 , Il13ra2 , Il15 , Il19 , Il2 , Il21 , Il22 , Il23a , Il23r , Il2ra , Il2rb , Il4 , Il4r , Il5 , Il5ra , Il6 , Il6r , Il9 , Il9r , Irf1 , Lep , Stat4 , Stat6 , Tslp
Asthma, Aspirin-InducedIl4
AstrocytomaAkt1 , Ptpn11
Ataxia TelangiectasiaIfng , Il2 , Il6
Ataxia-Oculomotor Apraxia 3Pik3r5
AtherosclerosisAkt1 , Ifng , Il2 , Il6 , Socs3 , Stat3
Atrial FibrillationIl2
AtrophyStat3
Attention Deficit Disorder with HyperactivityCrebbp
Autistic DisorderGhr , Ifng , Il10 , Il13 , Il15 , Il2 , Il4 , Il5 , Il6 , Lep , Prl , Prlr , Stat3
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1Stat3
Autoimmune DiseasesIfng , Il2rb , Il4 , Il6 , Stat3 , Stat6
Autoimmune Polyendocrinopathy Syndrome, Type 1Gh1
AzotemiaGh1
BacteremiaCish , Csf2
Bacterial InfectionsIl10 , Il2
Bardet-Biedl SyndromeAkt3
Basal Ganglia DiseasesPrl
BCG and Salmonella Infection, DisseminatedIl12b
BCG Infection, Generalized FamilialIfngr1
BCG Infection, Generalized Familial Semibenign, Autosomal DominantIfngr1
Behcet SyndromeIfng , Il10 , Il2 , Il21r , Il23r , Il4 , Il6 , Stat3 , Stat4
BerylliosisIl2ra , Il6
Beta-ThalassemiaEpo , Gh1 , Il6
Bile Duct NeoplasmsIl6
Biliary Tract NeoplasmsIl4 , Il6
Bipolar DisorderAkt1
Birdshot ChorioretinopathyIl2
Body Mass Index Quantitative Trait Locus 10Lepr
Body Mass Index Quantitative Trait Locus 11Lepr
Body Mass Index Quantitative Trait Locus 12Lepr
Body Mass Index Quantitative Trait Locus 14Lepr
Body Mass Index Quantitative Trait Locus 4Lepr
Body Mass Index Quantitative Trait Locus 7Lepr
Body Mass Index Quantitative Trait Locus 8Lepr
Body Mass Index Quantitative Trait Locus 9Lepr
Body Weight ChangesLep
Bone Diseases, MetabolicIl7
Bone Marrow Failure SyndromesCsf2
Bone Marrow NeoplasmsCsf3
BradycardiaPrl
Brain ConcussionIl6
Brain DiseasesIfnb1 , Ifng
Brain InfarctionIl15
Brain InjuriesAkt1 , Csf2 , Csf3 , Epo , Epor , Ifnl3 , Il10 , Il12rb2 , Il13ra2 , Il2 , Il3 , Il4 , Il5 , Il6 , Il7 , Il9r , Irf1 , Jak2 , Lep , Pias1 , Stat1 , Stat3
Brain IschemiaAkt1 , Bcl2l1 , Csf2rb , Csf3 , Epor , Il10rb , Il12rb1 , Il6 , Il6st , Lif , Ptk2b , Stat3
Brain NeoplasmsCcnd1 , Il2
Breast AdenocarcinomaAkt1 , Pik3ca
Breast Cancer, FamilialPik3r3
Breast NeoplasmsAkt1 , Akt2 , Bcl2l1 , Ccnd1 , Ccnd2 , Ccnd3 , Csf2 , Csf3 , Ep300 , Epo , Epor , Ghr , Ifnb1 , Ifng , Il13 , Il13ra2 , Il24 , Il6 , Lep , Lepr , Myc , Pik3ca , Pik3r1 , Pim1 , Ptk2b , Socs1 , Socs2 , Stat1 , Stat3 , Stat5a
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Akt1 , Pik3ca
Bronchial HyperreactivityIfng , Il10 , Il13 , Il15 , Il21r , Il4r , Il5
Bronchiolitis ObliteransCsf2 , Ifng , Il13 , Il13ra1 , Il13ra2 , Il4 , Il6
Bronchiolitis, ViralCsf2 , Il4r , Il6 , Il9
BronchitisIfng
Bronchitis, ChronicIl10 , Il13 , Il15
Budd-Chiari SyndromeJak2
Burkitt LymphomaMyc , Pik3r1
BurnsCcnd1 , Il10 , Il6 , Socs3
Burns, ChemicalIl6
CachexiaIl6
Cadmium PoisoningIl6
Cafe au lait Spots, MultipleSos1
Cafe-au-Lait SpotsSpred1
CalcinosisEpo , Jak2 , Ptpn6
Candidiasis, Chronic MucocutaneousStat1
Candidiasis, Familial, 7Stat1
CarcinomaBcl2l1 , Ccnd1 , Csf2 , Csf3 , Il6st , Myc , Pik3r1 , Prlr , Stat3 , Stat5a
Carcinoma in SituAkt1
Carcinoma, Adenoid CysticCcnd1 , Crebbp , Ep300 , Pik3ca
Carcinoma, Basal CellIl6 , Pik3ca
Carcinoma, BronchogenicIl10
Carcinoma, DuctalStat5a
Carcinoma, Ductal, BreastCcnd3 , Il13 , Socs1 , Socs2 , Socs3
Carcinoma, HepatocellularAkt1 , Akt2 , Bcl2l1 , Ccnd1 , Crebbp , Csf2 , Ep300 , Il10 , Il2 , Il6 , Il6st , Myc , Pik3ca , Socs3 , Stat1 , Stat4
Carcinoma, Intraductal, NoninfiltratingCcnd1 , Ccnd2 , Socs1 , Socs2 , Socs3 , Stat5a
Carcinoma, Lewis LungIl2
Carcinoma, LobularCcnd1 , Ccnd2 , Stat5a
Carcinoma, Merkel CellMyc
Carcinoma, Non-Small-Cell LungAkt1 , Akt2 , Cbl , Csf3 , Il10 , Il6r , Irf1 , Lep , Myc , Osmr , Pik3ca , Stat3
Carcinoma, Pancreatic DuctalIl4 , Il4r
Carcinoma, Renal CellAkt1 , Bcl2l1 , Ccnd1 , Ccnd3 , Il13 , Il2 , Il4r , Il6 , Il6r , Lep , Myc , Pik3ca , Stat3
Carcinoma, Small CellIl6
Carcinoma, Squamous CellAkt1 , Ccnd1 , Crebbp , Ep300 , Il2 , Il6 , Myc , Pik3ca , Ptpn11 , Stat3
Carcinoma, Squamous Cell of Head and NeckAkt1 , Crebbp , Ep300 , Ifnl3 , Il2 , Pik3ca , Stat3
Carcinoma, Transitional CellBcl2l1 , Ccnd1 , Ccnd2 , Crebbp , Csf3 , Ep300 , Ifnb1
Cardiac FibrosisCsf3
Cardiofaciocutaneous SyndromePtpn11
CardiomegalyAkt1 , Ccnd2 , Ctf1 , Ep300 , Il6 , Il6st , Lif , Myc , Stat3
CardiomyopathiesAkt1 , Ep300 , Epo , Il4 , Il6 , Stat3
Cardiomyopathy, DilatedCsf3 , Ctf1 , Il10 , Il13ra2 , Lepr , Ptpn11
Cardiomyopathy, HypertrophicCtf1 , Myc , Ptpn11 , Sos1
Cardiomyopathy, Hypertrophic, FamilialCtf1 , Sos1
Cardiovascular DiseasesGh1
Carotid Artery DiseasesIl10 , Prl
Carotid Artery InjuriesCbl , Csf3 , Myc
Carotid StenosisIl10 , Il4
CatalepsyPrl
CataractIfng
Cd4+ Lymphocyte DeficiencyJak3
Cecal NeoplasmsCcnd1
Celiac DiseaseIl15 , Il21 , Il23r , Il6
Cell Transformation, NeoplasticCcnd1 , Il6 , Il7r , Myc , Pim1 , Stat3
Central Nervous System DiseasesEpo , Il6
Cerebral HemorrhageBcl2l1 , Cntf , Csf3
Cervical Intraepithelial NeoplasiaCcnd1 , Stat3
Chagas CardiomyopathyIl10
Chagas DiseaseIfng
ChillsIfng
Chlamydia InfectionsIfng , Il13
ChloracneOsm
CholangiocarcinomaEpo , Epor , Il4r , Il6
CholestasisGhr , Il4 , Il6
CholesteatomaStat4
Cholesteatoma, Middle EarIl2 , Il6
ChorioamnionitisIl6
Choroid DiseasesIl10
Choroidal NeovascularizationIl10 , Il2 , Lep , Stat3
ChoroiditisIfng
Chromosome 5q Deletion SyndromeIrf1
Chromosome BreakageMyc
Chronic Lymphoid LeukemiaIl5 , Myc , Ptpn11
Chronic Myeloproliferative DisorderCsf3r
Churg-Strauss SyndromeIl5 , Stat3
Clear-Cell Metastatic Renal Cell CarcinomaEp300 , Myc
Cleft LipMyc , Spry2
Cleft PalateMyc , Spry2
Cocaine-Related DisordersPrl , Tyk2
Cockayne SyndromeGhr
Cognition DisordersCsf3 , Epo , Il4
Cold-Induced Sweating Syndrome 2Clcf1
ColitisIfng , Il10 , Il4 , Il5 , Il6
Colitis, ExperimentalCsf3 , Ifng , Il10 , Il2 , Il6
Colonic DiseasesGhr
Colonic NeoplasmsAkt1 , Akt2 , Ccnd1 , Ccnd2 , Ep300 , Ifng , Jak3 , Lep , Myc , Pik3ca , Pik3r1 , Stat3
Colonic PolypsGhr
Colorectal NeoplasmsAkt1 , Akt2 , Ccnd1 , Crebbp , Csf2 , Ep300 , Il6st , Pik3ca , Pik3r1 , Ptpn11
Common ColdIl10 , Il4
Common Variable ImmunodeficiencyIl21r
Condylomata AcuminataIl12b , Il4
Congenital Amegakaryocytic ThrombocytopeniaMpl
Congenital HypothyroidismGh1 , Ghr , Tpo
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Conjunctival DiseasesIl6
Conjunctivitis, AllergicIfng , Il10 , Il13 , Il4r , Irf1
Copper-Overload CirrhosisStat3
Corneal PerforationIfng
Corneal UlcerIl6
Coronary Artery DiseaseAkt1 , Epo , Il10 , Il15 , Il6
Coronary RestenosisMyc
Coronavirus InfectionsIl6
Costello SyndromePtpn11
CoughCsf2 , Il5
COWDEN SYNDROME 5Pik3ca
Craniofacial AbnormalitiesEp300 , Spry2
Craniosynostosis and Dental AnomaliesIl11ra1
Crohn DiseaseIfng , Il10 , Il12b , Il21r , Il23r , Il2ra , Il6 , Jak2 , Lep , Ptpn2 , Stat3 , Tyk2
CryoglobulinemiaIfnl3
CryptococcosisIl4r
CryptorchidismBcl2l1 , Cbl
Currarino TriadPik3ca
Cystic FibrosisCsf3r , Il13 , Il6 , Il9 , Il9r , Irf1 , Lep
CystitisCsf3 , Il11 , Il2 , Il4
Cystitis, InterstitialCsf2
Cytomegalovirus InfectionsIl5 , Stat1
Cytomegalovirus RetinitisIl10
Death, Sudden, CardiacIl6
Dementia, Multi-InfarctIl2
Dementia, VascularEpo
Demyelinating DiseasesMyc
Depression, PostpartumIl10
Depressive DisorderBcl2l1 , Csf3 , Il6 , Il6r
Depressive Disorder, MajorIl2 , Il3 , Il5
Dermal FibrosisStat4
DermatitisIl13
Dermatitis, Allergic ContactCish , Ifng , Il10 , Il2 , Il2ra , Il4 , Il5 , Pim1 , Socs1 , Socs2
Dermatitis, AtopicIfng , Ifnl3 , Il10 , Il13 , Il13ra1 , Il13ra2 , Il2 , Il21r , Il4 , Il4r , Il5 , Il6 , Stat6 , Tslp
Dermatitis, Atopic, 4Socs3
Dermatitis, ContactIl13 , Il4 , Osm
Dermatitis, IrritantIl4 , Stat3
Dermatitis, OccupationalIl13
DermatomyositisIfng , Il4 , Stat4
Developmental DisabilitiesAkt3 , Cbl , Tpo
Diabetes InsipidusGh1
Diabetes MellitusGh1 , Il10 , Il2ra , Il6 , Lepr
Diabetes Mellitus, ExperimentalAkt1 , Bcl2l1 , Ccnd3 , Ep300 , Epo , Epor , Gh1 , Ghr , Ifng , Il10 , Il2 , Il2ra , Il4 , Il4r , Il6 , Jak3 , Lep , Lepr , Myc , Pik3r1 , Socs3 , Stat1 , Stat3 , Stat4 , Stat5b
Diabetes Mellitus, Insulin-Dependent, 10Il2ra
Diabetes Mellitus, Type 1Cbl , Cblb , Gh1 , Ghr , Ifng , Il10 , Il15 , Il19 , Il2 , Il20 , Il21r , Il2ra , Il6 , Stat3
Diabetes Mellitus, Type 2Akt1 , Akt2 , Bcl2l1 , Ccnd2 , Ep300 , Epo , Gh1 , Ghr , Ifng , Il10 , Il6 , Lep , Lepr , Pik3r1 , Ptpn1 , Socs3 , Stat3
Diabetes, GestationalGh1 , Il10 , Il6 , Lep , Lepr
Diabetic AngiopathiesPtk2b
Diabetic CardiomyopathiesIl10
Diabetic FootIl15
Diabetic NephropathiesEp300 , Epo , Ghr , Ifng , Il10 , Il6 , Jak2 , Lep , Stat3
Diabetic NeuropathiesEpo , Ifng , Lepr
Diabetic RetinopathyEp300 , Epo , Gh1 , Il10 , Il6
DiarrheaCsf3
Disease Models, AnimalAkt1 , Ifng , Pim1 , Stat3
Disease ProgressionMyc , Stat1
Disease SusceptibilityCsf3
Disseminated Intravascular CoagulationIl10 , Il6
Drug EruptionsIl4
Drug HypersensitivityIl10 , Il13 , Il2 , Il4 , Il4r
Drug-induced agranulocytosisCsf3
Drug-induced AnemiaIfnl3
Drug-Induced Liver InjuryCsf3 , Ifng , Il11 , Il22 , Il4 , Il6
Drug-induced NeutropeniaCsf3
Drug-Related Side Effects and Adverse ReactionsCsf2 , Csf3 , Il3
Dry Eye SyndromesIfng , Il10 , Il6
Duodenal UlcerStat3
DwarfismGhr
Dwarfism, PituitaryGh1 , Ghr
DyslipidemiasLepr
Eales DiseaseIl10 , Il6
EchinococcosisIl5
EclampsiaIl6
EczemaIfngr1 , Il13 , Il4r , Stat4
EdemaIl11 , Il4 , Il6 , Jak3 , Stat6
Egg HypersensitivityIl13
Embryo LossLif
Encephalitis, Herpes SimplexStat4
Encephalomyelitis, Acute DisseminatedIfng
Encephalomyelitis, Autoimmune, ExperimentalCblb , Epo , Ifng , Il10 , Il10ra , Il12a , Il12b , Il13 , Il21 , Il21r , Il22 , Il2ra , Il4 , Il6 , Jak2 , Jak3 , Stat1 , Stat3 , Stat4
EnchondromatosisPtpn11
Endometrial NeoplasmsBcl2l1 , Ccnd1 , Ep300 , Il10 , Irf1 , Myc , Pik3ca , Socs2 , Socs3 , Stat3
EndometriosisBcl2l1 , Ifngr1 , Il10 , Il15 , Il7r , Prl , Prlr
EndophthalmitisIfng
EndotoxemiaCsf3 , Ep300 , Epo , Ghr , Ifng , Il10 , Il13 , Il6 , Socs1 , Socs3 , Stat5b
EntamoebiasisIfng , Il10 , Il2 , Il5 , Il6
Enterobacteriaceae InfectionsCsf3
EnterocolitisIl10
Enterocolitis, NecrotizingIl10 , Il10rb
EosinophiliaIl5 , Il5ra
Eosinophilic EnteropathyIl5
Eosinophilic EsophagitisIl5 , Tslp
Epidermal HyperplasiaStat3
Epidermal NevusPik3ca
EpilepsyAkt1
Epsilon-Trimethyllysine Hydroxylase DeficiencySpry3
Erectile DysfunctionAkt1 , Bcl2l1 , Ccnd1 , Ccnd2 , Il6 , Prl
Erythrocytosis, Familial, 1Epor , Jak2
Erythrocytosis, Familial, 2Jak2
Erythroleukemia, FamilialEpor
Esophageal NeoplasmsCcnd1 , Csf3 , Il5 , Myc
Esophageal Squamous Cell CarcinomaCcnd1 , Crebbp , Ep300
EsophagitisIl13 , Il4r
Esophagitis, PepticIl13 , Il5
Exostoses, Multiple HereditaryPtpn11
Eye BurnsIl10
Eyelid DiseasesCsf2 , Ifng
Facial AsymmetryPik3ca
Familial Mediterranean FeverIl6
Familial MyelofibrosisMpl
Fanconi AnemiaIfng , Il10
Farmer's LungIl12b
FatigueEpo
Fatty LiverIl10 , Il13ra2 , Il6 , Jak2 , Lep , Lepr , Myc , Socs1 , Socs3
Fatty Liver, AlcoholicStat4
Female Urogenital DiseasesLif
Femoral FracturesCsf2 , Il10 , Il2 , Il6 , Lep
Fetal DistressEpo , Epor
Fetal Growth RetardationLep , Ptpn11
Fetal Inflammatory Response SyndromeIl6
Fetal ResorptionPrl
FeverCsf3 , Ifng , Il2 , Il6 , Il6r , Prl , Stat3
Fibromatosis, GingivalSos1
Fibromatosis, Gingival, 1Sos1
FibrosisAkt1 , Ccnd2 , Csf3 , Il13 , Il4 , Lepr , Socs3 , Stat3 , Stat6
Food HypersensitivityIfnl3 , Il13 , Il5
Foot InjuriesIl6
GalactorrheaPrl
Galactorrhea-HyperprolactinemiaPrlr
GalactosemiasIl11ra1
Gallbladder NeoplasmsIl10 , Il4r
Gastrointestinal DiseasesCsf3
Gastrointestinal HemorrhageCsf2
Gastrointestinal NeoplasmsPik3ca
Gaucher DiseaseIl4
Genetic Diseases, InbornCrebbp , Il21r , Jak1 , Pik3r2 , Stat2
Genetic Predisposition to DiseaseIl10
Genomic InstabilityCcnd1
GerminomaCcnd2
Giant Cell ArteritisCsf2 , Ifng , Il21r , Il4
Giant Lymph Node HyperplasiaIl6
GingivitisIl6
GlaucomaCcnd2 , Cntf , Crebbp , Epo , Epor
Glaucoma, NeovascularIl6
Glaucoma, Open-AngleIl10 , Il2
GlioblastomaAkt1 , Crebbp , Il2 , Myc , Pik3ca , Pik3r1 , Pim1
GliomaAkt2 , Epo , Epor , Ifng , Il10 , Il12a , Il12b , Il2 , Il4 , Il7 , Pik3ca
GlomerulonephritisEp300 , Ifng , Il10 , Il2 , Il2ra , Il6 , Ptk2b , Tpo
Glomerulonephritis, CrescenticStat6
Glomerulonephritis, IGASpry2 , Stat4
Glomerulonephritis, MembranoproliferativeEp300 , Tslp
Glomerulosclerosis, Focal SegmentalPias1
Glucose IntoleranceJak2 , Lepr
Glucosephosphate Dehydrogenase DeficiencyIfng , Il10 , Il6
GoiterTpo
Graft vs Host DiseaseIfng , Il10 , Il10rb , Il2 , Il21r , Jak3
GranulomaIl4
Granuloma, PyogenicStat3
Granuloma, Respiratory TractIl13
Granulomatosis with PolyangiitisIl10
Granulomatous Disease, ChronicIfng
Granulosa Cell TumorCcnd2
Graves DiseaseIfng , Il10 , Il13 , Il2 , Il23r , Il3 , Il6 , Il6r , Stat4 , Stat6
Graves OphthalmopathyIfng , Il10 , Il2 , Il23r , Il3
Growth DisordersCbl , Gh1 , Jak2 , Pik3ca
Growth Hormone-Secreting Pituitary AdenomaGh1 , Prl
GynecomastiaPrl
Hamartoma Syndrome, MultipleAkt1 , Pik3ca
Hashimoto DiseaseIfng , Il6
Head and Neck NeoplasmsBcl2l1 , Csf3 , Pik3ca , Stat6
HeadacheCsf3 , Il6
Hearing LossBcl2l1 , Il10 , Stat1
Hearing Loss, Noise-InducedIl6
Hearing Loss, SensorineuralIfng , Il2
Hearing Loss, SuddenIl4r , Il6
Heart ArrestAkt1 , Ep300 , Ifng
Heart DiseasesCsf3 , Ep300 , Epo , Jak2 , Stat3
Heart FailureCbl , Csf2 , Csf3 , Epo , Ifng , Il10 , Il6 , Il6r , Lep , Lepr , Lif , Prl
Heart Septal Defects, VentricularEpo
Heart Valve DiseasesJak2 , Ptpn6
Heat Stress DisordersIl6
Heat StrokeIl10 , Il11ra1 , Il6 , Il6r
Helicobacter InfectionsIfngr1 , Socs3
Hemangioma, CapillaryAkt3
HemangiosarcomaCcnd1 , Csf3 , Myc , Stat3
HemarthrosisIl6
Hematologic DiseasesBcl2l1
Hematologic NeoplasmsCbl , Mpl
Hematoma, Subdural, AcuteEpo
HemimegalencephalyPik3ca
Hemolytic-Uremic SyndromeEpo , Il6
Hemophilia AIfng , Il10
HemorrhageIl11
Hemorrhagic Fever with Renal SyndromeIfng , Il2ra
Hemorrhagic Fever, EbolaIl3
Heparin-induced ThrombocytopeniaIl10
Hepatic EncephalopathyEpor
Hepatic Veno-Occlusive DiseaseCsf3
HepatitisIfng
Hepatitis BIfnb1 , Ifng , Ifngr1 , Il10rb
Hepatitis CIfnar1 , Ifng , Ifnl3 , Il10
Hepatitis C, ChronicIfnl3 , Stat3
Hepatitis, AcuteIl4
Hepatitis, AlcoholicIl13
Hepatitis, AutoimmuneIfng , Il10 , Il13 , Il2 , Il22 , Il4 , Il5 , Il6 , Il9 , Lep
Hepatitis, ChronicStat3
Hepatolenticular DegenerationIl10 , Il6
HepatomegalyLepr
Hernia, DiaphragmaticIl6
Hernias, Diaphragmatic, CongenitalCbl , Ep300 , Pim1 , Stat3
Heroin DependenceLep
Herpes GenitalisIfng , Il3 , Stat4
Herpes ZosterIl10 , Il2 , Il4
Hirschsprung Disease 1Crebbp
HirsutismEp300
HIV InfectionsIfng , Il10 , Il15 , Il2 , Il21r , Il2ra , Il4r , Il6 , Socs1 , Socs3
HIV Wasting SyndromeIl6
Hodgkin DiseaseCsf3 , Il10 , Il6 , Ptpn1
Huntington DiseaseCntf , Il6 , Il6r , Lep
Hyper-Ige Recurrent Infection Syndrome, Autosomal DominantIl4r , Stat3
HyperalgesiaCsf3 , Ep300 , Il10 , Il13 , Il2 , Il6 , Il6r , Jak2 , Jak3 , Stat3
HyperandrogenismIl6st
HyperbilirubinemiaCsf3
HypercalcemiaIl6
HypercapniaLep
HypercholesterolemiaCtf1 , Lep
Hypercholesterolemia, FamilialGhr
HyperglycemiaCbl , Cntf , Il6 , Lepr
HyperinsulinismIl6 , Lep , Lepr
HyperkinesisIl2
HyperlipidemiasLep , Lepr
Hyperlipoproteinemia Type IIGhr
HyperoxaluriaIl6
HyperoxiaIl6
HyperparathyroidismCcnd1 , Myc
Hyperparathyroidism, SecondaryIl6
HyperphagiaLep , Lepr
HyperplasiaAkt1 , Ccnd1 , Il13 , Il9 , Pik3ca
HyperprolactinemiaPrl , Prlr
HypersensitivityIfng , Il13 , Il2 , Il2rb , Il4 , Il5ra , Il6 , Il6st
Hypersensitivity, DelayedIfng , Il13
Hypersensitivity, ImmediateIl10 , Il13 , Il4 , Il4r
HypertensionAkt1 , Akt2 , Ctf1 , Ep300 , Epo , Epor , Il10 , Il6 , Il6r , Il6st , Lep , Lepr , Pik3r1 , Ptk2b
Hypertension, PortalPik3r1 , Prl
Hypertension, PulmonaryBcl2l1 , Csf3 , Epo , Ifngr1 , Il10 , Il13 , Il13ra1 , Il13ra2 , Il23r , Il4 , Il6 , Myc
Hypertension, RenalIl6
Hypertension, RenovascularPrl
HyperthyroidismIl10
HypertriglyceridemiaIl6st , Socs1 , Socs3
HypertrophyCsf3
Hypertrophy, Left VentricularCtf1 , Lepr , Lifr , Myc , Ptk2b
Hypertrophy, Right VentricularAkt1 , Gh1
HyperuricemiaJak2 , Stat3
HypoalbuminemiaGh1 , Il6
HypoglycemiaAkt2 , Epo , Pik3r1 , Prl
HypogonadismIl6 , Lep , Lepr , Prl
Hypogonadotropic Hypogonadism 17 with or without AnosmiaSpry4
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
HyponatremiaIfng
HypopituitarismPrl
HypoproteinemiaGh1
HypotensionCtf1 , Ifng , Il2 , Il6 , Prl
HypothermiaIl12a , Il12b
HypothyroidismIl10
HypoventilationLep
Hypoxia, BrainEp300 , Epo , Epor
Hypoxia-Ischemia, BrainBcl2l1 , Epo , Ghr , Il6
Idiopathic Interstitial PneumoniasIl6
Idiopathic Pulmonary FibrosisIl2ra , Stat3
Ige Responsiveness, AtopicIl21r , Il4r
IgG DeficiencyIfng
IL21R ImmunodeficiencyIl21r
Immune Complex DiseasesIfng
Immunodeficiency 14Pik3cd
Immunodeficiency 27BIfngr1
Immunodeficiency 30Il12rb1
Immunodeficiency 36Pik3r1
Immunodeficiency 44Stat2
Immunodeficiency, Common Variable, 11Il21
Immunologic Deficiency SyndromesIl2 , Lepr
InfarctionCsf3 , Prl
Infarction, Middle Cerebral ArteryCsf3 , Epo , Il11 , Il13 , Il22 , Il4 , Il5 , Il6 , Il6r , Il6st , Stat3
InfertilityLepr
Infertility, FemaleLep , Lepr , Lif , Prl
InflammationAkt1 , Csf2 , Epo , Ifng , Il10 , Il13 , Il15 , Il6 , Jak2 , Lep , Stat3
Inflammatory Bowel Disease 11Il10 , Il12b , Il23r , Il5 , Il7r , Jak2 , Ptpn2 , Stat3
Inflammatory Bowel Disease 17Il23r
Inflammatory Bowel Disease 25, Autosomal RecessiveIl10rb
Inflammatory Bowel Disease 28, Autosomal RecessiveIl10ra , Il10rb
Inflammatory Bowel DiseasesIl10 , Il10ra , Il10rb , Il21r , Il23r , Il5 , Il6
Influenza, HumanCsf2 , Il10 , Il12b , Il13 , Il15 , Il15ra , Il2 , Il22 , Il4 , Il6 , Stat1
Insulin ResistanceAkt2 , Cblb , Cntf , Ctf1 , Gh1 , Il6 , Il6r , Lep , Lepr , Pik3r1 , Prl , Ptk2b , Ptpn1 , Socs1 , Socs3
Intellectual DisabilityEp300 , Tpo
Interferon Gamma, Receptor 1, DeficiencyIfngr1 , Ifngr2
Interleukin 2 Receptor, Alpha, Deficiency ofIl2ra
Intervertebral Disc DisplacementAkt1
Intestinal Diseases, ParasiticIl5
Intestinal ObstructionIl10
Intestinal PolypsCcnd1
Intestinal Reperfusion InjuryCsf3 , Il6 , Jak2
Intracranial AneurysmIl6
Intracranial Arteriovenous MalformationsIl6
Intracranial HemorrhagesIl6
Intraventricular HemorrhageIl6
Irritable Bowel SyndromeIl10
IschemiaAkt2 , Il6
Ischemic Attack, TransientCbl , Csf3 , Ep300 , Epo , Il10 , Jak2 , Stat3
Isolated Growth Hormone Deficiency, Type IBGh1
Isolated Growth Hormone Deficiency, Type IIGh1
Job SyndromeIfng , Stat3
Kaposi Varicelliform EruptionIfng
KeratitisIl6
Keratitis, HerpeticIfng , Il10 , Stat4
Keratoconjunctivitis SiccaIl6
KeratoconusCntf
Keratosis, SeborrheicPik3ca
Kidney CalculiIfng
Kidney DiseasesCsf3 , Ctf1 , Epo , Lepr
Kidney Failure, ChronicEpo , Epor , Il20 , Il6 , Lep
Kidney NeoplasmsAkt1 , Ccnd1 , Il2
Kidney Reperfusion InjuryEp300 , Epo , Il10 , Lep , Myc , Stat6
Klebsiella InfectionsIl6
Kowarski SyndromeGh1
Language Development DisordersTpo
Laron SyndromeGhr
Laron Syndrome Type 2Stat5b
Lead Poisoning, Nervous SystemEp300
Learning DisordersGhr , Il6
Legionnaires' DiseaseIfng
Legius SyndromeSpred1
LeiomyomaBcl2l1 , Myc
LeiomyosarcomaCsf3
LeishmaniasisIfng , Il10 , Il2 , Il4 , Il6
Leishmaniasis, CutaneousIfng , Il10 , Il13 , Il4 , Stat4
Leishmaniasis, MucocutaneousIfng
Leishmaniasis, VisceralCsf2 , Ifng , Il10 , Il10ra , Il6 , Stat4
LEOPARD SyndromePtpn11
LeprosyIl23r
LEPTIN DEFICIENCY OR DYSFUNCTIONLep
Leptin Receptor DeficiencyLepr
LeukemiaCcnd1 , Il2 , Jak2 , Ptpn11
Leukemia, B-CellIl5 , Myc
Leukemia, Erythroblastic, AcuteEpor
Leukemia, ExperimentalCbl
Leukemia, Large Granular LymphocyticStat3 , Stat5b
Leukemia, Lymphocytic, Chronic, B-CellCbl , Ccnd1 , Ifng , Il10 , Il19 , Il6 , Ptpn11
Leukemia, LymphoidBcl2l1
Leukemia, Megakaryoblastic, AcuteJak3
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveBcl2l1 , Csf3r , Il10 , Jak2
Leukemia, MyeloidCsf3 , Ifng , Mpl
Leukemia, Myeloid, AcuteBcl2l1 , Cbl , Ccnd1 , Ccnd2 , Crebbp , Csf2 , Csf3 , Csf3r , Il10 , Il6 , Jak1 , Jak2 , Myc , Ptpn11 , Spry4 , Stat3
Leukemia, Myelomonocytic, ChronicCsf3r
Leukemia, Myelomonocytic, JuvenileCbl , Csf2 , Jak3 , Ptpn11
Leukemia, Neutrophilic, ChronicCsf3r
Leukemia, Prolymphocytic, T-CellJak3
Leukemia, Promyelocytic, AcuteAkt1 , Ifng , Myc
Leukemia, T-CellPtpn2 , Stat3
Leukemia-Lymphoma, Adult T-CellIfng , Il10 , Il2 , Il4 , Il5 , Il6 , Jak3 , Stat3
Leukemoid ReactionJak3
LeukocytosisCsf3 , Csf3r
LeukopeniaCsf3 , Il2 , Il3
Leydig Cell TumorPrl
Lichen PlanusIfng
Lichen Planus, OralIl2
Lichenoid EruptionsIl6
Limb IschemiaCsf2 , Csf3 , Epo
Lipodystrophy, Familial PartialAkt2
ListeriosisIl15
Liver CirrhosisIfng , Ifnl3 , Il6 , Stat1 , Stat3
Liver Cirrhosis, AlcoholicIl6 , Jak2
Liver Cirrhosis, BiliaryIl12a , Il12b , Il4 , Il7r , Jak2 , Lep , Lepr , Stat4 , Tyk2
Liver Cirrhosis, ExperimentalCsf3 , Gh1 , Ghr , Ifng , Ifngr1 , Il10 , Il2rb , Il2rg , Il6 , Il7r , Jak2 , Lep , Lepr , Myc , Osm , Prlr , Ptpn1 , Socs1 , Socs2
Liver DiseasesBcl2l1 , Csf3 , Il11 , Il9r , Socs1 , Socs3
Liver Failure, AcuteCsf3 , Il6
Liver InjuryCsf3 , Il6 , Jak2 , Myc , Stat3
Liver NeoplasmsAkt1 , Ccnd1 , Crebbp , Csf2 , Csf3 , Il10 , Il12a , Il12b , Il2 , Myc , Pik3ca , Stat3
Liver Neoplasms, ExperimentalBcl2l1 , Ccnd1 , Myc , Socs1
Liver Reperfusion InjuryBcl2l1 , Il10 , Il6 , Jak2
Lung DiseasesCsf3 , Il10 , Il13 , Il15 , Il4r , Il6 , Il9 , Irf1 , Lep , Spry2
Lung Diseases, FungalIl13
Lung Diseases, InterstitialIl2 , Il4r
Lung InjuryCsf3 , Il6
Lung NeoplasmsAkt1 , Bcl2l1 , Ccnd1 , Ifng , Il10 , Il2 , Il24 , Il6 , Irf1 , Myc , Pik3ca , Spry2 , Stat5a
Lung Reperfusion InjuryIl4 , Myc
Lupus Erythematosus, SystemicEpor , Ifng , Il10 , Il12b , Il13 , Il2 , Il21 , Il21r , Il23r , Il4 , Il5 , Il6 , Jak2 , Prl , Stat4
Lupus NephritisIfng , Stat4 , Stat6
LymphangioleiomyomatosisStat1 , Stat3
Lymphatic MetastasisIl13 , Socs2 , Socs3 , Stat3
Lymphoblastic Leukemia, Acute, with Lymphomatous FeaturesCrlf2 , Il7r , Jak1 , Jak2 , Jak3
Lymphocytic ChoriomeningitisIl21r
LymphomaIl10
Lymphoma, AIDS-RelatedCsf2 , Csf3
Lymphoma, B-CellCsf2 , Csf3 , Il21r , Ptpn1
Lymphoma, FollicularCrebbp
Lymphoma, Large B-Cell, DiffuseIl21r , Pik3ca , Pik3cb , Pik3cd
Lymphoma, Large-Cell, AnaplasticStat3
Lymphoma, Mantle-CellCcnd1 , Pik3cd
Lymphoma, Non-HodgkinCcnd1 , Csf2 , Csf3 , Myc , Pik3ca
Lymphoma, T-CellAkt1 , Ep300 , Il13 , Il13ra2 , Jak3 , Stat3 , Stat5b
Lymphoma, T-Cell, CutaneousIl4 , Stat5b
LymphopeniaCbl , Il2ra , Il7
Lymphoproliferative DisordersIfng , Stat3
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
Macular EdemaEpo , Il6
MalariaCish
Malaria, CerebralJak3
Malaria, FalciparumIl13
Malformations of Cortical DevelopmentAkt3 , Pik3ca
Mammary Neoplasms, AnimalCcnd1 , Il6st , Pik3r1 , Prl , Prlr , Stat3 , Stat5a
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bcl2l1 , Ccnd1 , Ccnd3 , Epo , Epor , Gh1 , Il10 , Il6st , Lep , Myc , Pik3r1 , Prl , Prlr , Socs1 , Socs3 , Stat1 , Stat3 , Stat5a , Stat6
Manganese PoisoningIfng
Marijuana AbuseAkt1
MastocytosisIl13 , Il4r , Il5ra
Mediastinal NeoplasmsPtpn1
MedulloblastomaCrebbp , Ep300 , Mpl , Myc , Pik3ca , Stat3
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Ccnd2 , Pik3ca , Pik3r2
MegalencephalyAkt3
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 3Ccnd2
MelanomaAkt1 , Bcl2l1 , Cbl , Crebbp , Csf2 , Csf3 , Ep300 , Epo , Epor , Ifnb1 , Ifng , Il2 , Myc , Pik3ca , Pik3r1 , Ptk2b , Tpo
Melanoma, AmelanoticIfnb1
Melanoma, Cutaneous MalignantStat3
Melanoma, Cutaneous Malignant, Susceptibility To, 1Akt1 , Cbl , Pik3ca , Tpo
Melanoma, ExperimentalIfnb1 , Il2
Memory DisordersStat3
Meningeal NeoplasmsAkt1
MeningiomaAkt1
Meningitis, AsepticIl6
Meningitis, PneumococcalIl6
Mesenteric Vascular OcclusionJak2
MesotheliomaIfng
Mesothelioma, MalignantIfng , Il12b , Il2ra , Il3 , Il4 , Il6 , Osmr
Metabolic Syndrome XIl6 , Il6r , Lep , Prl
Metabolism, Inborn ErrorsLepr
MetachondromatosisPtpn11
MetaplasiaIl13
MicrocephalyEp300
MicrognathismEp300
Microvascular Complications of Diabetes, Susceptibility To, 2Epo
Microvascular Complications of Diabetes, Susceptibility To, 3Epo
Microvascular Complications of Diabetes, Susceptibility To, 7Epo
Milk HypersensitivityIl13
Mitochondrial MyopathiesIl6
Mitral Valve StenosisIl10
Mixed Connective Tissue DiseaseIfng
Mood DisordersAkt1
Mouth NeoplasmsPik3ca
Mucocutaneous Lymph Node SyndromeIl13 , Il4
MucositisCsf2 , Csf3 , Il10
Multiple Fibroadenomas of the BreastPrlr
Multiple MyelomaBcl2l1 , Cbl , Ccnd1 , Ccnd2 , Ccnd3 , Csf2 , Csf3 , Il10 , Il4r , Il6 , Pik3ca , Ptpn11
Multiple Organ FailureIl10
Multiple SclerosisCblb , Cntf , Ifnb1 , Ifng , Il12a , Il13 , Il21r , Il23r , Il2ra , Il4 , Il4r , Il6 , Il7 , Il7r , Stat4 , Tyk2
Multiple Sclerosis, Chronic ProgressiveIl4r
Murine Acquired Immunodeficiency SyndromeIl10
Muscle HypotoniaEp300
Muscle WeaknessCsf2 , Csf3
Muscular AtrophyAkt1 , Gh1 , Ghr
Muscular DiseasesCsf3
Myasthenia GravisIl2rb
Myasthenia Gravis, Autoimmune, ExperimentalIl15 , Il23r , Il2ra , Il4r
Mycobacterial and Viral Infections, Susceptibility To, Autosomal RecessiveStat1
Mycobacterial Disease, Mendelian Susceptibility toIfngr1 , Ifngr2
Mycobacterium InfectionsIfng , Il22 , Stat1
Mycobacterium Infections, NontuberculousIfngr1 , Ifngr2 , Il12b , Il12rb1 , Stat1 , Tyk2
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TOCish , Ifng , Ifngr1
Mycobacterium Tuberculosis, Susceptibility To Infection ByCish , Ifngr1 , Il12rb1
Myelitis, TransverseIl6
Myelodysplastic SyndromesCsf3r , Epo , Myc
Myeloproliferative DisordersCbl , Jak2 , Jak3 , Mpl
Myocardial InfarctionAkt1 , Bcl2l1 , Csf2 , Csf3 , Epo , Epor , Gh1 , Il10 , Il4r , Il6 , Il6r , Jak2 , Socs1
Myocardial IschemiaCcnd1 , Ccnd2 , Ghr , Ifngr1 , Il6 , Il6st , Irf1 , Jak2 , Lepr , Socs3 , Stat5a
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bcl2l1 , Cbl , Il10 , Il6 , Il6r , Jak2 , Lep , Lepr , Stat1 , Stat3
MyocarditisIl10 , Il21r , Il22 , Stat6
Myocarditis, Autoimmune, ExperimentalIl13 , Il6
Myoclonus, Familial CorticalMyc
MyopiaEp300
NarcolepsySocs2
Nasal PolypsIfng , Il10 , Il13 , Il5ra , Il9 , Lepr , Stat3
Nasopharyngeal carcinomaAkt2 , Ccnd1 , Pik3ca
Nasopharyngeal NeoplasmsCcnd1 , Pik3ca
NauseaIfng
NecrosisCtf1 , Epo , Ifng , Il6
Nematode InfectionsIl4 , Pik3r1
NeointimaPtk2b , Stat4
Neoplasm InvasivenessEpo , Epor , Il6
Neoplasm MetastasisAkt2 , Ccnd2 , Csf3 , Epo , Epor , Il10 , Il2 , Il6 , Myc , Osm , Stat3
Neoplasm, ResidualCsf2 , Il2
NeoplasmsCsf2 , Ifng , Il2 , Il3 , Myc , Pik3ca , Pik3r1
Neoplasms, ExperimentalCcnd1 , Ifnb1 , Ifng , Il12a , Il12b , Il2
Neoplasms, Germ Cell and EmbryonalCcnd2
Neoplasms, Plasma CellBcl2l1
Neoplasms, Second PrimaryCsf3
Neoplastic Syndromes, HereditaryPik3ca
NephritisCcnd2 , Ifng , Il4 , Ptk2b
Nephrosis, LipoidIl13 , Stat6
Nephrotic SyndromeEpo , Il2 , Il4 , Il5 , Jak2
Nerve DegenerationCntf , Epo , Epor , Ifng , Lep
Nervous System DiseasesCsf3
Nervous System MalformationsSpred1
Neural Tube DefectsCsf2 , Ifng
NeuralgiaIl10
Neuritis, Autoimmune, ExperimentalEpo , Il5
NeuroblastomaIfnb1 , Myc , Pik3ca , Ptpn11
Neurodegenerative DiseasesEpo , Il6
Neuroectodermal TumorsMyc
Neurofibromatosis 1Spred1
Neurogenic InflammationIl2
Neuromyelitis OpticaIl6
Neuropathy, PainfulEp300
Neurotoxicity SyndromesBcl2l1 , Il10
NeutropeniaCsf2 , Csf3
Neutropenia, Severe ChronicCsf3r
NEUTROPENIA, SEVERE CONGENITAL, 7, AUTOSOMAL RECESSIVECsf3r
NeutrophiliaCsf3
Neutrophilia, HereditaryCsf3r
Niemann-Pick Disease, Type CJak2 , Stat3
Non-alcoholic Fatty Liver DiseaseCsf2 , Il13 , Il3 , Il4 , Il6 , Jak2 , Lep , Lif , Stat3
Noonan like syndromeCbl , Ptpn11 , Sos1
Noonan SyndromeCbl , Ptpn11 , Sos1
Noonan Syndrome 4Sos1
NOONAN SYNDROME 9Sos2
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaCbl
ObesityAkt1 , Akt2 , Cntf , Ctf1 , Ep300 , Gh1 , Ifng , Il10 , Il15 , Il3 , Il6 , Il6r , Jak2 , Lep , Lepr , Myc , Pik3r1 , Prl , Ptpn1 , Socs1 , Socs3 , Stat3 , Stat4
Obesity, MorbidLep , Lepr
Obstetric Labor, PrematureIl6
Ocular HypertensionBcl2l1
OnchocerciasisIl13
Optic Nerve InjuriesCsf3 , Ep300
Optic Neuropathy, IschemicCsf3
Oral Squamous Cell CarcinomaIl13ra2 , Il2 , Il6
Oral Submucous FibrosisIfng
Oral UlcerLep , Stat4
OrchitisIl6r
OsteoarthritisGh1 , Ghr , Il4r , Il5 , Lep
Osteoarthritis, HandIl4 , Il4r
Osteoarthritis, HipGhr , Il4r
Osteoarthritis, KneeEpo , Il2 , Il4 , Lep , Lepr
OsteochondrodysplasiasLifr
OsteochondromaPtpn11
OsteopetrosisGhr
OsteophyteGh1
OsteoporosisGh1 , Ghr , Il6 , Il6r , Lep , Lepr , Myc
Osteoporosis, PostmenopausalIl6 , Il7 , Ptk2b
Osteoporotic FracturesGh1
OsteosarcomaAkt1 , Il3 , Myc
Otitis MediaIfng , Il10 , Il2 , Il6
Otitis Media with EffusionIfng , Il4 , Il4r
Otitis Media, SuppurativeIfng
Ovarian Epithelial CancerPik3ca
Ovarian Hyperstimulation SyndromeIl6
Ovarian NeoplasmsAkt1 , Akt2 , Bcl2l1 , Ccnd1 , Ccnd2 , Ccnd3 , Il10 , Il11ra1 , Il13 , Il6 , Il6st , Myc , Pik3ca , Pik3r1 , Socs1 , Socs2 , Stat3
OverweightLepr
Oxygen-Induced RetinopathyStat3
PainAkt1 , Csf2 , Csf3 , Il2 , Il6st
Pancreatic AdenocarcinomaPik3ca
Pancreatic DiseasesIl6 , Lepr
Pancreatic NeoplasmsAkt2 , Bcl2l1 , Ifng , Il10 , Il13 , Il13ra2 , Il2 , Il24 , Il3 , Il4 , Il4r , Myc , Stat3
PancreatitisIl10 , Il13 , Il15 , Lepr
Pancreatitis, Acute NecrotizingIl6
Pancreatitis, ChronicIfng
Pancreatitis, Experimental, Acute Bcl2l1 , Il10 , Il4
PancytopeniaCsf3 , Epo
PanuveitisIfng , Il10
Papillary Renal Cell Carcinoma, SporadicMyc , Pik3ca
PapillomaCcnd1
Paraneoplastic SyndromesEpo
Paranoid DisordersTyk2
ParaplegiaAkt1
Parkinson DiseaseAkt1 , Epo , Il6 , Lep
Parkinsonian DisordersCsf2 , Prl
Peanut HypersensitivityIl13
Pelvic Inflammatory DiseaseIl4
Pemphigoid, BullousIl2
PemphigusIl2
Penile NeoplasmsCcnd1 , Pik3ca
Pericardial EffusionIl10
Periodontal DiseasesIl15 , Il19 , Il21 , Il24 , Il6 , Il7
PeriodontitisIfngr1 , Il10 , Il6
Peripheral Nerve InjuriesGh1 , Il6 , Il6r
Peripheral Nervous System DiseasesCsf3 , Il6
Peripheral Vascular DiseasesIl6
PeritonitisIfng
Phobic DisordersPrl
Picornaviridae InfectionsIl13
Pituitary DiseasesLepr
Pituitary Dwarfism 1Gh1
Pituitary NeoplasmsGh1 , Il6st , Prl
Placental InsufficiencyEpo
PlasmacytomaIl10
Pleomorphic Xanthoastrocytoma Epo , Il6 , Lep
Pleural DiseasesIfng , Il4 , Il6
Pleural EffusionIl15
PleurisyCsf3 , Il10 , Il15 , Il6
PneumoconiosisIl4
PneumoniaCsf2 , Ifnar1 , Ifng , Il10 , Il13 , Il13ra2 , Il2rb , Il4 , Il5ra , Il6 , Il6st
Pneumonia, BacterialCsf3 , Csf3r , Ifnar1 , Il15 , Il22 , Irf1 , Lep , Stat3
Pneumonia, MycoplasmaIfng , Il13
Pneumonia, PneumococcalIl15 , Il15ra , Il6 , Lep , Lepr
Pneumonia, PneumocystisCsf2
Pneumonia, StaphylococcalCsf3 , Ifnar1 , Il10 , Il15
Pneumonia, ViralIfnar1 , Il10 , Il15
Pneumovirus InfectionsIl21r
PoisoningCsf3 , Epo
Polychondritis, RelapsingIfng
Polycystic Kidney Disease, Type 1Myc
Polycystic Kidney DiseasesMyc , Stat6
Polycystic Kidney, Autosomal DominantMyc , Stat6
Polycystic Kidney, Autosomal RecessiveAkt1 , Myc , Pik3ca
Polycystic Ovary SyndromeLep , Lif , Lifr
PolycythemiaEpor , Gh1 , Jak2
Polycythemia VeraBcl2l1 , Epor , Jak1 , Jak2
PolydipsiaLep
PolymicrogyriaAkt3
PolymyositisIfng , Il4 , Il6 , Stat4
PolyneuropathiesEpo , Il6
Polyomavirus InfectionsIl15
PolyuriaLep
PorphyriasEpo
Postoperative Atrial FibrillationIl6
Pre-EclampsiaLep , Lepr
Precancerous ConditionsCcnd1 , Stat3 , Stat5a
Precursor B-Cell Lymphoblastic Leukemia-LymphomaBcl2l1 , Ccnd1 , Crlf2 , Stat3
Precursor Cell Lymphoblastic Leukemia-LymphomaBcl2l1 , Ccnd1 , Crebbp , Crlf2 , Csf3 , Gh1 , Ifng , Il10 , Myc
Precursor T-Cell Lymphoblastic Leukemia-LymphomaCsf3r , Il7r , Jak3 , Ptpn11 , Ptpn2
Prediabetic StateIl15 , Il6
Pregnancy ComplicationsEpo , Jak2
Pregnancy Complications, CardiovascularIl6 , Prl
Pregnancy-associated MalariaIl10
Premature BirthIl4 , Il6
Pressure UlcerIl10
Primary Graft DysfunctionIl10
Primary MyelofibrosisJak2 , Mpl
ProgeriaGh1
ProlactinomaMyc , Prl
Proliferative Diabetic RetinopathyIl6r
Prostatic HyperplasiaIl13 , Il3 , Il5 , Myc , Prl
Prostatic Intraepithelial NeoplasiaCcnd1 , Myc , Pim1
Prostatic NeoplasmsAkt1 , Bcl2l1 , Ccnd1 , Ccnd2 , Ccnd3 , Cntfr , Crebbp , Ep300 , Ghr , Il10 , Il2 , Il24 , Il6 , Jak2 , Lep , Lifr , Myc , Pik3ca , Pik3cd , Pik3r1 , Ptk2b , Socs1 , Stat1 , Stat3 , Stat5b , Stat6
ProstatitisIl10
ProteinuriaIfng , Il6 , Lep
Proteus SyndromeAkt1
Pseudomonas Aeruginosa KeratitisIl10 , Il6
Pseudomonas InfectionsCsf2 , Il13 , Il24
PsoriasisCsf2 , Ifnlr1 , Il10 , Il12b , Il13 , Il13ra1 , Il2 , Il20 , Il23a , Il23r , Il3 , Il4 , Il6 , Stat3 , Stat4 , Tyk2
Psychoses, Substance-InducedAkt1
Psychotic DisordersCntf
Puberty, DelayedLepr
Puerperal DisordersPrl
Pulmonary Alveolar ProteinosisCsf2
Pulmonary ContusionIl6
Pulmonary Disease, Chronic ObstructiveBcl2l1 , Csf2 , Il12b , Il13 , Il13ra1 , Il5 , Il5ra , Il6 , Il9 , Lep , Lepr , Stat4
Pulmonary EdemaIl13
Pulmonary EmbolismEpo
Pulmonary EmphysemaCsf3 , Il13
Pulmonary EosinophiliaIl10 , Il13 , Il5
Pulmonary FibrosisCsf2 , Csf3 , Il12b , Il13 , Il15 , Il4 , Il5 , Il6 , Il9 , Lepr , Stat1 , Stat3
PulpitisIfng
PurpuraIl13
Purpura, Schoenlein-HenochIl5
Purpura, Thrombocytopenic, IdiopathicIl10 , Il2 , Il4
PyelonephritisIl3 , Pim1
QuadriplegiaIl6
Radiation InjuriesCsf2
Radiation Injuries, ExperimentalIfng , Il10
Radiation PneumonitisIl13
RASopathiesCbl , Ptpn11 , Sos1 , Spred1
Rectal NeoplasmsPik3ca
RecurrenceCrlf2
Renal FibrosisIfng , Myc , Stat6
Renal InsufficiencyEpo , Ifng
Renal Insufficiency, ChronicIl19
Reoviridae InfectionsStat1
Reperfusion InjuryAkt1 , Ccnd1 , Ep300 , Gh1 , Ifng , Il10 , Il12a , Il13 , Il6 , Il6r , Il6st , Irf1 , Jak2 , Lep , Pik3r1 , Ptk2b , Socs1 , Socs3 , Socs4 , Stat1 , Stat2 , Stat3 , Stat5a , Stat5b , Stat6
Respiratory Distress Syndrome, AdultIl10 , Il15 , Il9 , Lep
Respiratory HypersensitivityIl10 , Il13 , Il13ra1 , Il15 , Il4 , Il6 , Ptpn6
Respiratory InsufficiencyIl15
Respiratory SoundsIl13 , Il4
Respiratory Syncytial Virus InfectionsIfng , Il10 , Il13 , Il2ra , Il5 , Il5ra , Il6 , Il9 , Irf1
Respiratory Tract DiseasesIfng
Respiratory Tract InfectionsIl13 , Il4 , Il6r , Irf1 , Lepr
Retina Reperfusion InjuryBcl2l1 , Cntf , Il6 , Stat3
Retinal Artery OcclusionIl10 , Il6
Retinal DegenerationEpo , Il6st
Retinal DetachmentEpo , Epor , Il6 , Jak2
Retinal DiseasesIl10
Retinal Necrosis Syndrome, AcuteIfng
Retinal VasculitisIl6
Retinal Vein OcclusionIl6
Retinopathy of PrematurityEpo , Epor , Il10
Retroviridae InfectionsIl10
Rett SyndromePtpn1
Rhabdoid TumorMyc
Rheumatic Heart DiseaseIl10
Rheumatoid Arthritis, Systemic JuvenileIl6 , Il6r
RhinitisIl13 , Il13ra2 , Il15 , Il2 , Il21 , Il22 , Il22ra1 , Il23r , Il4 , Il4r , Il5 , Il9 , Lep
Rhinitis, AllergicIfng , Il10 , Il13 , Il13ra2 , Il2 , Il4 , Il5
Rhinitis, Allergic, PerennialIfngr1 , Il13 , Il2 , Il4 , Il5
Rhinitis, Allergic, SeasonalIfngr1 , Il10 , Il4
RhinosinusitisIl10 , Il4
Rubinstein-Taybi SyndromeCrebbp , Ep300
Salivary Gland NeoplasmsCcnd1
Salmonella InfectionsIl12b
Salmonella Infections, AnimalIfng
SarcoidosisIl23r
Sarcoidosis, PulmonaryIl15
SarcomaCsf2 , Ifng , Pik3ca
Sarcoma, ExperimentalEpo , Ifng
Sarcoma, KaposiIl6
SarcopeniaIl6
Schistosomiasis HaematobiaIl5 , Stat6
Schistosomiasis MansoniIl13
SchizophreniaAkt1 , Il10 , Il2ra , Il6 , Il6r , Pik3cb
Sciatic NeuropathyIl10 , Il6 , Il6r
Scleroderma, DiffuseIl10 , Il6 , Stat4
Scleroderma, LimitedIl2 , Jak2 , Stat4
Scleroderma, LocalizedCsf3 , Il13
Scleroderma, SystemicIfng , Il13 , Il13ra1 , Il2 , Il23r , Il4 , Il6 , Stat4
ScoliosisCrebbp
ScrapieJak2 , Stat1 , Stat3
SeizuresCcnd1 , Epo , Ifnb1 , Ifng , Il6 , Il6r , Il6st , Lep
SeminomaCcnd2
Senile CataractGhr
Senior Loken SyndromeAkt3
SepsisCsf2 , Csf3 , Ep300 , Ghr , Ifng , Il10 , Il12b , Il13 , Il22 , Il6 , Jak2 , Lep , Socs1 , Socs2 , Socs3 , Stat1 , Stat3 , Stat4 , Stat6
Sepsis-Associated EncephalopathyJak2 , Stat3
Septic PeritonitisCsf3 , Il6 , Pik3r1
Severe Combined ImmunodeficiencyEpo , Il2 , Il2rg , Il7r , Jak3
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell Negative, B Cell Positive, NK Cell PositiveIl7r
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, NK Cell-NegativeIl7r , Jak3
Severe Congenital NeutropeniaCsf3r
Sexual Dysfunction, PhysiologicalPrl
Sexual Dysfunctions, PsychologicalPrl
Sezary SyndromeCrebbp , Il2rg , Stat4
Shock, CardiogenicEpo
Shock, HemorrhagicBcl2l1 , Epo , Ifng , Il10 , Il4 , Il6 , Myc
Shock, SepticIl10 , Il19 , Il20ra , Il20rb , Il6
Short Bowel SyndromeLep , Lepr
Short Stature, Idiopathic, AutosomalGh1 , Ghr
SHORT SyndromePik3r1
Shwartzman PhenomenonIl10 , Il6
SilicosisCsf2 , Il2ra
SinusitisIl13 , Il2
Sjogren's SyndromeIfng , Il10 , Il12a , Il13 , Il23r , Il6 , Stat4
Skin DiseasesIl10 , Il6 , Pias1
Skin NeoplasmsAkt1 , Csf3 , Ptk2b , Stat3
Sleep Apnea SyndromesIl6r , Lepr
Sleep Apnea, ObstructiveIl10 , Il6 , Lep , Lepr
Small Cell Lung CarcinomaAkt1 , Crebbp , Csf3 , Ep300 , Pik3ca
Smith-Magenis SyndromeCsf3 , Gh1 , Grb2 , Socs3 , Socs7 , Stat3 , Stat5a , Stat5b
Soft Tissue NeoplasmsCsf3
Solitary Fibrous TumorsStat6
Somatosensory DisordersCsf3
Spinal Cord CompressionEpo , Epor
Spinal Cord InjuriesAkt1 , Ccnd3 , Csf2 , Csf3 , Epo , Il4 , Il4r , Il6 , Irf1 , Jak2 , Lep , Socs2
Spinal FracturesLepr
SplenomegalyIl10 , Il6st
SpondylarthropathiesIl6
Spondylitis, AnkylosingIl12b , Il23r , Il6 , Jak2
Squamous Cell Carcinoma of the LungAkt1 , Crebbp , Ep300 , Pik3ca , Ptpn11
Squamous Cell Carcinoma of the TongueIfng , Il10 , Il2 , Jak3
Staphylococcal InfectionsIl10 , Il2 , Il4
Status AsthmaticusIfng , Il5
Status EpilepticusBcl2l1 , Ccnd1 , Epo , Il6st , Ptk2b , Socs3
Stevens-Johnson SyndromeCsf3 , Ep300 , Ifng
Stomach NeoplasmsBcl2l1 , Ccnd1 , Il6 , Il6r , Irf1 , Myc , Pik3ca , Stat3
Stomach UlcerBcl2l1 , Epo , Lep
StomatitisCsf3
Stress Disorders, Post-TraumaticIl2
StrokeAkt1 , Bcl2l1 , Csf3 , Il10 , Il4r , Il6 , Irf1 , Jak2 , Lif
Strongylida InfectionsIl3
StrongyloidiasisIl5
Stuve-Wiedemann syndromeLifr
Subarachnoid HemorrhageEpo , Stat3
Subretinal fibrosisIl6 , Il6r
Substance Withdrawal SyndromePrl
Surfactant Metabolism Dysfunction, Pulmonary, 1Csf2rb
Surfactant Metabolism Dysfunction, Pulmonary, 4Csf2ra
Surfactant Metabolism Dysfunction, Pulmonary, 5Csf2rb
Systemic VasculitisCsf3
T-LymphocytopeniaStat5b
TachycardiaLep
Tachycardia, VentricularEpo
Takayasu ArteritisIl2
Testicular NeoplasmsCcnd2
Tetralogy of FallotPtpn11
Thrombocythemia 2Mpl
Thrombocythemia 3Jak2
Thrombocythemia, EssentialJak2 , Mpl , Tpo
ThrombocytopeniaCsf2 , Csf3 , Epo , Ifnl3 , Il10 , Il3 , Il6 , Mpl
ThrombocytosisEpor , Jak2 , Mpl
Thrombocytosis, Benign Familial MicrocyticMpl
ThromboembolismJak2
ThrombosisEpo , Il10 , Pik3cb
Thumb DeformityCrebbp
Thyroid Dyshormonogenesis 2ATpo
Thyroid NeoplasmsCcnd1 , Csf2 , Epo , Epor , Il12b , Il6
Thyroiditis, AutoimmuneIfng , Il4 , Il6
Thyroiditis, ChronicIfng
ThyrotoxicosisIl10
TinnitusIl4r
Tongue NeoplasmsStat3
Toxoplasma ChorioretinitisIl10 , Il6
Toxoplasmosis, OcularIl10
TrachomaIl10
Transplant RejectionCsf3 , Ifng , Il10 , Il13 , Il15 , Il2 , Il5 , Il7 , Myc , Stat4 , Tpo
Trauma, Nervous SystemStat1
TrichinellosisIl10
TrichuriasisIfng
TrypanosomiasisIl4
TuberculosisIfngr1 , Il15 , Il22
Tuberculosis, BovineIl4
Tuberculosis, MeningealIl4r
Tuberculosis, OcularIl10
Tuberculosis, PulmonaryIl13 , Il15 , Il4 , Il4r , Il6 , Il6r , Irf1
Tuberculosis, RenalIl4r
Tuberous SclerosisIfng
Tuberous Sclerosis 1Ifng
Tuberous Sclerosis 2Ifng
Tubulointerstitial FibrosisEpo
Turner SyndromeGh1
Tympanic Membrane PerforationIl6
Tyrosine Kinase 2 DeficiencyTyk2
UremiaEpo
Ureteral ObstructionAkt1 , Ifng , Irf1
Urinary Bladder NeoplasmsAkt1 , Bcl2l1 , Ccnd3 , Crebbp , Csf3 , Ep300 , Ifnb1 , Ifng , Il2 , Myc , Socs1
Urologic NeoplasmsCcnd1
Uterine Cervical NeoplasmsAkt1 , Bcl2l1 , Ccnd1 , Ccnd3 , Crebbp , Ep300 , Il10 , Myc , Pias3 , Pik3ca , Stat3
Uterine NeoplasmsBcl2l1 , Csf3
UveitisIfng , Il10 , Il13 , Il21r , Il23r , Il6 , Il6r
Uveitis, AnteriorIfng
Uveitis, Autoimmune, ExperimentalIl10 , Stat3
Uveitis, IntermediateIl10
Uveomeningoencephalitic SyndromeIfng , Stat4
Uveoretinitis, Autoimmune, ExperimentalIfng , Il10 , Il2 , Il4 , Stat3
Vaginal NeoplasmsIl2
Varicose UlcerLepr
Vascular DiseasesEpo , Il15
VasculitisCbl , Il10
Vasculitis, Leukocytoclastic, CutaneousCsf3
Venous ThrombosisCsf2 , Epo , Il10 , Jak2
Ventilator-Induced Lung InjuryAkt1 , Il10 , Il22
Ventricular Dysfunction, LeftCsf3 , Il6
Ventricular FibrillationEpo
Vesico-Ureteral RefluxIfng
Virus DiseasesIfnar1 , Il15
VitiligoIfng , Il13 , Il2 , Il4
Vitreoretinopathy, ProliferativeIl6
VomitingIfng
von Hippel-Lindau DiseaseCcnd1
Waldenstrom MacroglobulinemiaIl10 , Il6
Weight GainGh1 , Lep , Pik3ca
Weight LossEpo , Il10 , Il4 , Lep , Lif
Wet Macular DegenerationIl6
Wilms TumorBcl2l1 , Ccnd2 , Myc , Stat1 , Stat3
Wounds and InjuriesIl10 , Il6
Wounds, PenetratingEpo , Il10
X-Linked Combined Immunodeficiency DiseasesIl2rg
XerostomiaIl4
Pathway Annotations Associated with Genes in the Jak-Stat signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pim1 , Sos1 , Sos2 , Stat3 , Stat5a , Stat5b
adenosine signaling pathwayAkt1 , Pik3ca
aldosterone signaling pathwayCrebbp , Jak2 , Pias1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
allograft rejection pathwayIfng , Il10 , Il12a , Il12b , Il2 , Il4 , Il5
altered energy homeostasis pathwayLep , Lepr
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered Jak-Stat signaling pathwayJak2 , Jak3
altered leptin system pathwayLep , Lepr
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
amyotrophic lateral sclerosis disease pathwayBcl2l1
androgen signaling pathwayCrebbp , Ep300 , Pias2
angiotensin II signaling pathwayJak2
angiotensin II signaling pathway via AT1 receptorJak2 , Tyk2
angiotensin II signaling pathway via AT2 receptorPtpn6
antigen processing and presentation pathwayIfng
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Csf2rb , Il3 , Il3ra , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
asthma disease pathwayIl10 , Il13 , Il3 , Il4 , Il5 , Il9
ataxia telangiectasia-mutated (ATM) signaling pathwayPias1 , Pias4
autoimmune thyroid disease pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Il10 , Il2 , Il4 , Il5 , LOC100911527 , Tpo
autophagy pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , LOC100911527
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn6 , Sos1 , Sos2
bladder cancer pathwayCcnd1 , Myc
brain-derived neurotrophic factor signaling pathwayGrb2
calcium/calcium-mediated signaling pathwayPtk2b
cell cycle pathway, mitoticCcnd1 , Ccnd2 , Ccnd3 , Crebbp , Ep300 , Myc
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Ccnd1 , Jak1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Jak2 , Jak3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptk2b , Sos1 , Sos2 , Stat1 , Stat2 , Stat3 , Stat5b
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Cbl , Cblb , Cblc , Ccnd1 , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Sos1 , Sos2 , Stat5a , Stat5b
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
cortisol signaling pathwayCrebbp , Ep300
cytokine mediated signaling pathwayClcf1 , Cntf , Cntfr , Crlf2 , Csf2 , Csf2ra , Csf2rb , Csf3 , Csf3r , Ctf1 , Epo , Epor , Ghr , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ifng , Ifngr1 , Ifngr2 , Ifnk , Ifnlr1 , Il10 , Il10ra , Il10rb , Il11 , Il11ra1 , Il12a , Il12b , Il12rb1 , Il12rb2 , Il13 , Il13ra1 , Il15 , Il2 , Il20ra , Il20rb , Il21 , Il21r , Il22 , Il22ra1 , Il22ra2 , Il23a , Il23r , Il2ra , Il2rb , Il2rg , Il3 , Il3ra , Il4 , Il4r , Il5 , Il5ra , Il6 , Il6r , Il6st , Il7 , Il7r , Il9 , Il9r , Lep , Lepr , Lif , Lifr , LOC100911527 , Mpl , Osm , Osmr , Prl , Prlr , Tpo , Tslp
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Pik3ca , Pik3r1
eicosanoid signaling pathwayAkt1 , Pik3r5
endocytosis pathwayCbl , Cblb , Cblc , Il2ra , Il2rb , Il2rg , Stam , Stam2
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
endothelin signaling pathwayAkt1 , Jak2 , Ptk2b
energy homeostasis pathwayLep , Lepr
Entamoeba histolyca infection pathwayCsf2 , Ifng , Il10 , Il12a , Il12b , Il6 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
ephrin - ephrin receptor bidirectional signaling axisCbl , Grb2 , Pik3ca , Pik3r1 , Pik3r5
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn1 , Ptpn11 , Ptpn6 , Sos1 , Sos2 , Stat1 , Stat3 , Stat5a , Stat5b
erythropoietin signaling pathwayBcl2l1 , Cbl , Epo , Epor , Grb2 , Jak2 , Pik3r1 , Ptpn11 , Ptpn6 , Socs3 , Sos1 , Stat1 , Stat5a , Stat5b
estrogen signaling pathwayCrebbp , Ep300
FasL mediated signaling pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Csf2 , Grb2 , Il13 , Il3 , Il4 , Il5 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
fibroblast growth factor signaling pathwayAkt1 , Cbl , Grb2 , Pik3ca , Pik3r1 , Ptk2b , Ptpn11 , Sos1 , Spry2 , Stat1 , Stat5b
forkhead class A signaling pathwayAkt1 , Crebbp , Ep300
G1 phase pathwayCcnd1
G1/S transition pathwayCcnd1 , Ccnd2 , Ccnd3
glioma pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
gonadotropin-releasing hormone signaling pathwayGrb2 , Ptk2b , Sos1 , Sos2
graft-versus-host disease pathwayIfng , Il2 , Il6
granulocyte-macrophage colony-stimulating factor signaling pathwayCish , Csf2 , Csf2rb , Grb2 , Jak2 , Osm , Pik3ca , Pik3r1 , Pim1 , Ptpn11 , Sos1 , Stat1 , Stat3 , Stat5a , Stat5b
growth hormone signaling pathwayGhr , Jak2
Hedgehog signaling pathwayAkt1 , Crebbp , Pias1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Grb2 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Irf1 , Irf9 , Jak1 , LOC100911527 , Pias1 , Pias2 , Pias3 , Pias4 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs3 , Sos1 , Sos2 , Stat1 , Stat2 , Stat3
histone modification pathwayCrebbp , Ep300
Huntington disease pathwayCrebbp , Ep300
hypertrophic cardiomyopathy pathwayIl6
hypoxia inducible factor pathwayAkt1 , Crebbp , Ep300 , Epo , Lep
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Crebbp , Ep300 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ifng , Ifngr1 , Ifngr2 , Il12a , Il12b , Il6 , Irf9 , Jak1 , Jak2 , LOC100911527 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs3 , Stat1 , Stat2
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Cbl
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn1 , Ptpn11 , Socs1 , Socs2 , Socs3 , Socs4 , Socs6 , Socs7 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1 , Ptpn1 , Ptpn11 , Sos1
interleukin-1 signaling pathwayPik3ca , Pik3r1
Interleukin-10 signaling pathwayIl10 , Il10ra , Il10rb , Jak1 , Stat1 , Stat3 , Tyk2
interleukin-12 signaling pathwayIfng , Il12a , Il12b , Il12rb1 , Il12rb2 , Il2 , Il2ra , Il2rb , Il2rg , Il4 , Jak2 , Socs1 , Stat1 , Stat3 , Stat4 , Stat5a , Stat6 , Tyk2
interleukin-2 signaling pathwayCish , Grb2 , Ifng , Il2 , Il2ra , Il2rb , Il2rg , Jak1 , Jak3 , Myc , Pik3ca , Pik3r1 , Ptk2b , Ptpn11 , Socs1 , Socs2 , Socs3 , Sos1 , Stam , Stam2 , Stat1 , Stat3 , Stat5a , Stat5b
interleukin-23 signaling pathwayIfng , Il12b , Il12rb1 , Il19 , Il2 , Il23a , Il23r , Il24 , Il6 , Jak2 , Pik3ca , Pik3r1 , Socs3 , Stat1 , Stat3 , Stat4 , Stat5a , Tyk2
interleukin-27 signaling pathwayIfng , Il12a , Il12b , Il12rb1 , Il12rb2 , Il2 , Il6 , Il6st , Jak1 , Jak2 , Stat1 , Stat2 , Stat3 , Stat4 , Stat5a , Tyk2
interleukin-3 signaling pathwayBcl2l1 , Cish , Csf2rb , Grb2 , Il3 , Il3ra , Jak2 , Osm , Pik3ca , Pik3r1 , Pim1 , Ptpn11 , Stat5a , Stat5b
interleukin-4 signaling pathwayAkt1 , Cbl , Grb2 , Il10 , Il13ra2 , Il2rg , Il4 , Il4r , Il5 , Jak1 , Jak2 , Jak3 , Pik3ca , Pik3r1 , Ptpn6 , Socs1 , Socs3 , Socs5 , Stat5a , Stat5b , Stat6
interleukin-5 signaling pathwayCish , Csf2rb , Grb2 , Il5 , Il5ra , Jak2 , Pik3ca , Pik3r1 , Pim1 , Ptpn11 , Stat5a , Stat5b
interleukin-6 signaling pathwayAkt1 , Grb2 , Il6 , Il6r , Il6st , Irf1 , Jak1 , Jak2 , Myc , Pias1 , Pias3 , Pik3ca , Pik3r1 , Ptpn11 , Socs3 , Sos1 , Sos2 , Stat1 , Stat3 , Tyk2
intrinsic apoptotic pathwayBcl2l1
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Cbl , Cblb , Cblc , Ccnd1 , Ccnd2 , Ccnd3 , Cish , Clcf1 , Cntf , Cntfr , Crebbp , Crlf2 , Csf2 , Csf2ra , Csf2rb , Csf3 , Csf3r , Ctf1 , Ep300 , Epo , Epor , Gh1 , Ghr , Grb2 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ifng , Ifngr1 , Ifngr2 , Ifnk , Ifnl3 , Ifnlr1 , Il10 , Il10ra , Il10rb , Il11 , Il11ra1 , Il12a , Il12b , Il12rb1 , Il12rb2 , Il13 , Il13ra1 , Il13ra2 , Il15 , Il15ra , Il19 , Il2 , Il20 , Il20ra , Il20rb , Il21 , Il21r , Il22 , Il22ra1 , Il22ra2 , Il23a , Il23r , Il24 , Il2ra , Il2rb , Il2rg , Il3 , Il3ra , Il4 , Il4r , Il5 , Il5ra , Il6 , Il6r , Il6st , Il7 , Il7r , Il9 , Il9r , Irf1 , Irf9 , Jak1 , Jak2 , Jak3 , Lep , Lepr , Lif , Lifr , LOC100911527 , Mpl , Myc , Osm , Osmr , Pias1 , Pias2 , Pias3 , Pias4 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pim1 , Prl , Prlr , Ptk2b , Ptpn1 , Ptpn11 , Ptpn2 , Ptpn6 , Socs1 , Socs2 , Socs3 , Socs4 , Socs5 , Socs6 , Socs7 , Sos1 , Sos2 , Spred1 , Spred2 , Spred3 , Spry2 , Spry3 , Spry4 , Stam , Stam2 , Stat1 , Stat2 , Stat3 , Stat4 , Stat5a , Stat5b , Stat6 , Tpo , Tslp , Tyk2
Leishmania infection pathwayIfng , Ifngr1 , Ifngr2 , Il10 , Il12a , Il12b , Il4 , Jak1 , Jak2 , Ptpn6 , Stat1
leptin system pathwayJak2 , Lep , Lepr , Ptpn1 , Ptpn11 , Socs3 , Stat3
long term potentiationCrebbp , Ep300
measles infection pathwayAkt1 , Akt2 , Akt3 , Cblb , Ccnd1 , Ccnd2 , Ccnd3 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ifng , Ifngr1 , Ifngr2 , Il12a , Il12b , Il13 , Il2 , Il2ra , Il2rb , Il2rg , Il4 , Il6 , Irf9 , Jak1 , Jak2 , Jak3 , LOC100911527 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat2 , Stat3 , Stat5a , Stat5b
melanoma pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Myc , Sos1 , Sos2
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Crebbp , Ep300 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnb1 , Ifng , Ifngr1 , Ifngr2 , Il10 , Il10ra , Il10rb , Il12a , Il12b , Il23a , Il6 , Jak1 , Jak2 , LOC100911527 , Stat1
myocarditis pathwayCcnd1
N-cadherin signaling pathwayPik3ca , Pik3r1 , Ptpn1 , Ptpn11
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Sos1 , Sos2
NOD-like receptor signaling pathwayIl6
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Non-Stat, Jak dependent pathwayJak1 , Tyk2
Notch signaling pathwayCbl , Ccnd1 , Crebbp , Ep300 , Il4 , Myc
nuclear factor kappa B signaling pathwayIrf1 , Pik3ca , Pik3r1
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp
obesity disease pathwayLepr
p38 MAPK signaling pathwayIrf1
p53 signaling pathwayAkt1 , Ccnd1 , Ccnd2 , Ccnd3 , Crebbp , Ep300
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Ccnd1 , Jak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
Plasmodium infection pathwayCsf3 , Ifng , Il10 , Il12a , Il6
platelet-derived growth factor signaling pathwayCbl , Grb2 , Ifng , Jak1 , Jak2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn1 , Ptpn11 , Sos1 , Stat1 , Stat3 , Stat5a , Stat5b
primary immunodeficiency disease pathwayIl2rg , Il7r , Jak3
prion diseases pathwayIl6
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Crebbp , Ep300 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Ras family mediated signaling pathwaySos1
Reelin signaling pathwayAkt1 , Cbl , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Crebbp , Ep300 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Sos1 , Sos2
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnb1 , Ifnk , Il12a , Il12b , LOC100911527
rheumatoid arthritis disease pathwayCsf2 , Ifng , Il11 , Il15 , Il23a , Il6
Rho/Rac/Cdc42 mediated signaling pathwayCbl , Ptk2b
RNA polymerase I transcription pathwayCrebbp
S phase pathwayCcnd1
scatter factor/hepatocyte growth factor signaling pathwayCbl , Grb2 , Pik3r1 , Ptpn11
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Ccnd1 ,