TYPE 2 DIABETES MELLITUS PATHWAY (PW:0000208)

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Description

Type 2 diabetes mellitus (T2D) is reaching epidemic proportions worldwide, yet the genetic underpinnings of the disease continue to be remarkably elusive. The importance and impact of environmental factors such as diet and lifestyle on the susceptibility of the disease only add additional challenges to the identification of genetic causes. While it is known that several pathways important for the maintenance of glucose homeostasis are altered in T2D, less is known about the molecular mechanisms

Pathway Diagram:

Elsevier Inc. anti-diabetic drug pathway Abcc8 Kcnj11 type 2 diabetes mellitus diabetic complications other T2D candidate genes potential T2D miRNAs altered insulin secretion pathway Insr Akt2 altered insulin signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway altered insulin responsive facilitative sugar transporter mediated glucose transport pathway metformin drug pathway other T2D candidate genes ---> insulin gene expression potential T2D miRNAs ---> insulin secretion potential T2D miRNAs ---> insulin gene expression beta-cell function insulin gene expression insulin secretion other T2D candidate genes ---> insulin secretion Islet development potential T2D miRNAs ---> Islet development other T2D candidate genes ---> beta-cell function insulin action potential T2D miRNAs ---> insulin action anti-diabetic drug pathway ---| altered insulin secretion pathway high blood glucose potential T2D miRNAs ---> diabetic complications potential T2D miRNAs ---> type 2 diabetes mellitus metformin drug pathway ---| diabetic complications metformin drug pathway ---| type 2 diabetes mellitus metformin drug pathway ---| high blood glucose Ins
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Genes in Pathway:

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type 2 diabetes mellitus pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:2313628
RGD:6907045
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:2313408
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:6907045
G Cacna1b calcium voltage-gated channel subunit alpha1 B JBrowse link 3 1,740,026 1,924,959 RGD:6907045
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:6907045
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:6907045
G Cacna1e calcium voltage-gated channel subunit alpha1 E JBrowse link 13 71,899,445 72,534,992 RGD:6907045
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:6907045
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:6907045
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:6907045
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6907045
G Hk3 hexokinase 3 JBrowse link 17 10,134,726 10,152,976 RGD:6907045
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:6907045
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:2313694
RGD:6907045
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:2313694
RGD:6907045
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:6907045
G Irs2 insulin receptor substrate 2 JBrowse link 16 83,824,515 83,848,569 RGD:6907045
G Irs3 insulin receptor substrate 3 JBrowse link 12 22,120,305 22,125,103 RGD:6907045
G Irs4 insulin receptor substrate 4 JBrowse link X 113,003,824 113,018,088 RGD:6907045
G Kcnj11 potassium voltage-gated channel subfamily J member 11 JBrowse link 1 102,103,093 102,107,134 RGD:2313610
RGD:2313628
RGD:6907045
G Mafa MAF bZIP transcription factor A JBrowse link 7 116,779,368 116,781,815 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6907045
G Pdx1 pancreatic and duodenal homeobox 1 JBrowse link 12 9,496,044 9,501,211 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pklr pyruvate kinase, liver and RBC JBrowse link 2 188,449,158 188,458,034 RGD:6907045
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6907045
G Prkce protein kinase C, epsilon JBrowse link 6 9,483,400 9,973,396 RGD:6907045
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6907045
G Slc2a2 solute carrier family 2 member 2 JBrowse link 2 114,413,427 114,445,418 RGD:6907045
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6907045
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:6907045
G Socs2 suppressor of cytokine signaling 2 JBrowse link 7 36,495,496 36,500,878 RGD:6907045
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6907045
G Socs4 suppressor of cytokine signaling 4 JBrowse link 15 24,056,383 24,070,868 RGD:6907045
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupOther T2D candidate genesCandidate genes have been identified in linkage analyses and GWAS studies as potential susceptibility loci for T2D;
Gene GroupPotential T2D miRNAsSeveral microRNAs (miRNAs) with potential roles in beta-cell and insulin function as well as in diabetic complications [see for instance the references PMID: 18655850 or 19471090] have been identified in humans and animal models.

Pathway Gene Annotations

Disease Annotations Associated with Genes in the type 2 diabetes mellitus pathway
Disease TermsGene Symbols
Aberrant Crypt FociMapk1 , Mapk3
Abnormalities, MultipleCacna1c , Cacna1g , Mapk1
Acne VulgarisTnf
Acquired Immunodeficiency SyndromeTnf
Acute Coronary SyndromeTnf
Acute Kidney InjuryIns2 , Mtor , Tnf
Acute Lung InjuryAdipoq , Tnf
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
AdenocarcinomaMtor , Pik3ca , Tnf
Adenocarcinoma of EsophagusPik3ca
Adenocarcinoma of LungPik3ca
ADENOCARCINOMA OF STOMACHMtor , Pik3ca
Adenocarcinoma, ColonMapk1 , Mapk3 , Pik3r3
Adenocarcinoma, ColorectalMapk1 , Mapk3 , Mapk8
Adenocarcinoma, ProstaticPik3ca , Pik3cb
AdenomaCacna1d , Ins2
Adenoma, ColorectalMapk8
Adenosine Triphosphate, Elevated, of ErythrocytesPklr
Adiponectin, Serum Level of, Quantitative Trait Locus 2Adipoq
Adiponectin, Serum Level of, Quantitative Trait Locus 3Adipoq
Adrenocortical CarcinomaPik3ca
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AIDS Dementia ComplexInsr , Irs1
AIDS-Associated NephropathyMtor
AlbuminuriaIns2 , Tnf
Alveolar Bone LossTnf
Alveolitis, Extrinsic AllergicTnf
Alzheimer DiseaseAdipoq , Ikbkb , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Mapk10 , Mapk8 , Mapk9 , Pik3r1 , Slc2a4 , Tnf
AmyloidosisAdipoq , Tnf
Amyotrophic Lateral SclerosisTnf
Amyotrophic Lateral Sclerosis 1Tnf
AnemiaHk1 , Tnf
Anemia, AplasticTnf
Anemia, Hemolytic, Congenital NonspherocyticHk1 , Pklr
Anemia, Hypochromic MicrocyticTnf
Anemia, Iron-DeficiencyTnf
Anemia, RefractoryTnf
Anemia, Sickle CellHk1 , Tnf
Angina, StableTnf
AngiomyolipomaMtor
AnorexiaTnf
AnthracosisTnf
Anti-Glomerular Basement Membrane DiseaseMapk8 , Tnf
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisTnf
Anxiety DisordersTnf
Aortic Aneurysm, AbdominalMapk8
Arrhythmias, CardiacCacna1c
Arsenic PoisoningTnf
ArteriosclerosisMapk9
Arthritis, ExperimentalAdipoq , Ikbkb , Mtor , Pik3cd , Socs3 , Tnf
Arthritis, InfectiousTnf
Arthritis, JuvenileMapk1
Arthritis, PsoriaticTnf
Arthritis, RheumatoidAdipoq , Tnf
AsbestosisTnf
Aspergillosis, Allergic BronchopulmonaryTnf
AsthmaAdipoq , Tnf
Asthma, OccupationalTnf
AtaxiaCacna1a
Ataxia-Oculomotor Apraxia 3Pik3r5
AtherosclerosisAdipoq , Socs3 , Tnf
Atrial FibrillationTnf
AtrophyMapk3
Autism Spectrum DisorderMapk3
Autistic DisorderCacna1c , Tnf
Autoimmune Lymphoproliferative Syndrome, Type IIIPrkcd
Behcet SyndromeAdipoq , Tnf
BerylliosisTnf
Beta-ThalassemiaTnf
Biliary AtresiaAdipoq
Bipolar DisorderAdipoq , Cacna1c , Ins2
bladder urothelial carcinomaPik3ca
Brain EdemaAbcc8 , Tnf
Brain InfarctionAdipoq
Brain InjuriesAbcc8 , Tnf
Brain IschemiaMapk1 , Mapk3 , Mapk8 , Prkcd , Tnf
Breast AdenocarcinomaPik3ca
Breast Cancer, FamilialPik3r3
Breast NeoplasmsAdipoq , Akt2 , Ikbkb , Insr , Mapk1 , Mtor , Pik3ca , Pik3r1 , Slc2a2 , Socs1 , Socs2 , Tnf
Bronchial HyperreactivityTnf
BronchiectasisTnf
Bronchiolitis, ViralTnf
Bronchopulmonary DysplasiaTnf
Brugada SyndromeCacna1c
Brugada Syndrome 3Cacna1c
Burkitt LymphomaPik3r1
BurnsMtor , Pklr , Prkcd , Socs3 , Tnf
CachexiaTnf
CarcinomaPik3r1
Carcinoma, Adenoid CysticPik3ca
Carcinoma, Basal CellPik3ca
Carcinoma, Ductal, BreastCacna1c , Socs1 , Socs2 , Socs3
Carcinoma, EndometrioidPik3r2
Carcinoma, HepatocellularAkt2 , Irs1 , Irs2 , Mtor , Pik3ca , Slc2a2 , Socs3 , Tnf
Carcinoma, Intraductal, NoninfiltratingSocs1 , Socs2 , Socs3
Carcinoma, Non-Small-Cell LungAkt2 , Pik3ca , Tnf
Carcinoma, Pancreatic DuctalIns2 , Slc2a2
Carcinoma, Renal CellInsr , Mtor , Pik3ca , Tnf
Carcinoma, Small CellMtor , Tnf
Carcinoma, Squamous CellMapk1 , Mapk3 , Pik3ca
Carcinoma, Squamous Cell of Head and NeckMapk1 , Pik3ca
Carcinoma, Transitional CellMapk1 , Mtor , Pik3ca , Tnf
Cardiac Complexes, PrematureCacna1c
CardiomegalyMapk1 , Mapk8 , Mtor , Prkcd , Prkce , Slc2a4 , Tnf
CardiomyopathiesAdipoq , Insr , Mapk1 , Mapk3 , Prkce , Tnf
Cardiomyopathy, DilatedTnf
Cardiomyopathy, HypertrophicIns2
Cardiomyopathy, RestrictiveCacna1c , Prkcd
Cardiovascular DiseasesAdipoq
Cardiovirus InfectionsTnf
Cell Transformation, NeoplasticIrs1 , Mapk8
Cerebellar AtaxiaCacna1a
Cerebral HemorrhageMtor
Cerebral InfarctionPdx1 , Tnf
Ceroid Lipofuscinosis, Neuronal, 6Mapk1 , Mapk3
Chlamydia InfectionsTnf
CholestasisTnf
Cholesteatoma, Middle EarTnf
ChondrosarcomaMtor
ChorioamnionitisTnf
ChoriocarcinomaInsr
Choroidal NeovascularizationAdipoq , Ikbkb
Chronic Allograft DysfunctionMtor , Tnf
Chronic Intermittent HypoxiaHk1 , Hk2
Cocaine-Related DisordersMapk1 , Mapk3
ColitisAdipoq , Ikbkb , Tnf
Colitis, ExperimentalTnf
colon cancerPik3ca
Colonic NeoplasmsAkt2 , Ikbkb , Mapk8 , Mapk9 , Pik3ca , Pik3r1 , Pik3r2 , Pik3r5 , Tnf
colorectal cancerPik3ca
Colorectal NeoplasmsAbcc8 , Akt2 , Hk1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Prkce , Tnf
Congenital HyperinsulinismAbcc8 , Gck , Kcnj11
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Congenital Myasthenic Syndrome IbCacna1c
Corneal UlcerTnf
Coronary AneurysmAdipoq
Coronary Artery DiseaseAdipoq , Gck , Irs1 , Tnf
Coronary DiseaseAdipoq , Irs1
Coronary RestenosisAdipoq , Mapk1 , Tnf
Coronary StenosisPrkce
CoughTnf
COWDEN SYNDROME 5Pik3ca
Coxsackievirus InfectionsTnf
Crohn DiseaseAdipoq , Tnf
CryoglobulinemiaTnf
Currarino TriadPik3ca
Cystic FibrosisTnf
CystitisTnf
Cystitis, InterstitialMtor , Tnf
Cytomegalovirus InfectionsTnf
Cytomegalovirus RetinitisTnf
DeafnessCacna1d
Death, Sudden, CardiacCacna1c
DementiaAdipoq
Dementia, VascularMtor
Demyelinating DiseasesTnf
DermatitisIkbkb , Tnf
Dermatitis HerpetiformisTnf
Dermatitis, Allergic ContactSocs1 , Socs2 , Tnf
Dermatitis, AtopicMapk8 , Tnf
DermatomyositisTnf
Developmental DisabilitiesCacna1a
Diabetes MellitusAbcc8 , Adipoq , Gck , Ins1 , Ins2 , Insr , Irs1 , Kcnj11 , Pdx1 , Slc2a2
Diabetes Mellitus, ExperimentalAdipoq , Gck , Hk1 , Ikbkb , Insr , Irs1 , Irs2 , Kcnj11 , Mapk1 , Mapk3 , Pdx1 , Pik3r1 , Pklr , Prkcd , Prkce , Slc2a2 , Slc2a4 , Socs3 , Tnf
Diabetes Mellitus, Insulin-Dependent, 2Ins1 , Ins2
Diabetes Mellitus, Insulin-Resistant, with Acanthosis NigricansInsr
Diabetes Mellitus, LipoatrophicInsr
Diabetes Mellitus, New-Onset after TransplantationMtor
Diabetes Mellitus, Permanent NeonatalAbcc8 , Gck , Ins1 , Ins2 , Kcnj11 , Pdx1
Diabetes Mellitus, Permanent Neonatal, with Neurologic FeaturesAbcc8 , Kcnj11
Diabetes Mellitus, Transient Neonatal, 2Abcc8
Diabetes Mellitus, Transient Neonatal, 3Kcnj11
Diabetes Mellitus, Type 1Abcc8 , Adipoq , Ins2 , Kcnj11 , Pdx1 , Tnf
Diabetes Mellitus, Type 2Abcc8 , Adipoq , Akt2 , Gck , Hk1 , Hk2 , Ikbkb , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Kcnj11 , Pdx1 , Pik3r1 , Slc2a2 , Slc2a4 , Socs3 , Tnf
Diabetes, GestationalAdipoq , Gck , Ins2 , Insr
Diabetic AngiopathiesTnf
Diabetic CardiomyopathiesAdipoq , Ins2 , Tnf
Diabetic FootAdipoq
Diabetic KetoacidosisIns2 , Insr
Diabetic NephropathiesAdipoq , Ins2 , Irs2 , Mapk1 , Mtor , Prkce , Tnf
Diabetic NeuropathiesInsr , Tnf
Diabetic RetinopathyAdipoq , Ins2 , Tnf
Disease Models, AnimalMapk1 , Mapk3 , Mapk8 , Mapk9 , Tnf
Disseminated Intravascular CoagulationTnf
Donohue SyndromeInsr
Drug HypersensitivityTnf
Drug-Induced Liver InjuryAdipoq , Tnf
Dry Eye SyndromesAdipoq , Tnf
DysarthriaCacna1a
Dyskinesia, Drug-InducedCacna1d , Mtor
DystoniaIns2
Dystonia 23Cacna1b
Eales DiseaseTnf
EdemaIns2 , Tnf
EmphysemaTnf
EncephalitisTnf
EncephalomyelitisTnf
Encephalomyelitis, Autoimmune, ExperimentalCacna1b , Tnf
Endometrial NeoplasmsPik3ca , Socs2 , Socs3
EndometriosisTnf
EndophthalmitisTnf
EndotoxemiaAbcc8 , Adipoq , Irs1 , Socs1 , Socs3 , Tnf
Enterocolitis, NecrotizingTnf
Epidermal NevusPik3ca
EpilepsyCacna1c
Epilepsy, AbsenceCacna1a
Epilepsy, GeneralizedCacna1a , Mapk10
Epilepsy, Temporal LobeCacna1a , Mtor
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 42Cacna1a
Epileptic Encephalopathy, Lennox-Gastaut TypeMapk10
Episodic Ataxia with NystagmusCacna1a
Erectile DysfunctionTnf
Erythema NodosumTnf
Esophageal NeoplasmsPik3ca
EsophagitisTnf
Esophagitis, PepticTnf
Exfoliation SyndromeCacna1a
Eye DiseasesTnf
Facial AsymmetryPik3ca
Familial Mediterranean FeverAdipoq
Fanconi AnemiaTnf
Fanconi SyndromeSlc2a2
Farmer's LungTnf
Fatty LiverAdipoq , Gck , Ins2 , Mapk8 , Prkcd , Slc2a2 , Socs1 , Socs3 , Tnf
Fatty Liver, AlcoholicAdipoq
Fetal Growth RetardationAdipoq , Irs1 , Irs2 , Pdx1 , Slc2a2
FeverTnf
Fibromatosis, AggressiveTnf
FibrosisSocs3 , Tnf
Focal Cortical Dysplasia of TaylorMtor
GastrinomaSlc2a2
GastritisTnf
Gastrointestinal NeoplasmsPik3ca
Gaucher DiseasePklr , Tnf
Genetic Diseases, InbornCacna1a , Cacna1c , Cacna1e , Cacna1g , Mapk1 , Pik3r2
GlaucomaTnf
Glaucoma, Open-AngleTnf
Glaucoma, Primary Open AngleAdipoq , Tnf
GlioblastomaMtor , Pik3ca , Pik3r1
GliomaAkt2 , Pik3ca , Tnf
GliosisMapk1 , Mapk3
GlomerulonephritisMapk1 , Tnf
Glomerulonephritis, CrescenticMtor
Glomerulonephritis, IGATnf
Glomerulosclerosis, Focal SegmentalTnf
GlucagonomaSlc2a2
Glucose IntoleranceIns2 , Insr
Glycogen Storage DiseaseSlc2a2
Graft vs Host DiseaseAdipoq
Graves DiseaseAdipoq , Tnf
Graves OphthalmopathyTnf
Growth DisordersPik3ca
Growth Restriction, Severe, with Distinctive FaciesIns1
Hamartoma Syndrome, MultiplePik3ca
Head and Neck NeoplasmsMapk1 , Mapk3 , Pik3ca
Hearing LossTnf
Hearing Loss, High-FrequencyTnf
Hearing Loss, Noise-InducedTnf
Hearing Loss, SensorineuralTnf
Hearing Loss, SuddenTnf
Heart ArrestAbcc8 , Ins2 , Tnf
Heart FailureAdipoq , Ins2 , Mtor , Slc2a4 , Tnf
Heat StrokeTnf
Helicobacter InfectionsSocs3
HemimegalencephalyMtor , Pik3ca
Hemiplegic Migraine, Familial Type 1Cacna1a
HemochromatosisTnf
Hemolytic Anemia, Nonspherocytic, due to Hexokinase DeficiencyHk1
Hemolytic-Uremic SyndromeTnf
Hepatic EncephalopathyTnf
HepatitisIns2
Hepatitis, AlcoholicTnf
Hepatitis, AutoimmuneAdipoq
Hepatitis, Viral, HumanAdipoq
Hepatolenticular DegenerationTnf
Hepatorenal SyndromeTnf
Hernia, DiaphragmaticTnf
Hernias, Diaphragmatic, CongenitalInsr , Tnf
Heroin DependenceAdipoq
Herpes ZosterTnf
Hidradenitis SuppurativaTnf
HirsutismCacna1g
HIV InfectionsSocs1 , Socs3 , Tnf
HIV Wasting SyndromeTnf
HIV-Associated Lipodystrophy SyndromeAdipoq
Huntington DiseaseAdipoq
HyperaldosteronismCacna1d
HyperalgesiaCacna1b , Insr , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Mtor , Prkce , Tnf
HyperbilirubinemiaTnf
HypercalcemiaTnf
HyperemiaAdipoq
HyperglycemiaCacna1e , Gck , Ins2 , Insr , Irs2 , Pdx1 , Pklr , Prkcz
HyperhomocysteinemiaTnf
Hyperinsulinemic Hypoglycemia, Familial, 3Gck
Hyperinsulinemic Hypoglycemia, Familial, 5Insr
HyperinsulinismAbcc8 , Adipoq , Gck , Ins2 , Insr , Irs1 , Kcnj11 , Pklr , Prkcd
HyperkalemiaIns2
HyperlipidemiasAdipoq , Irs1
HyperoxiaTnf
HyperplasiaAbcc8 , Ikbkb , Pik3ca
HyperproinsulinemiaIns1 , Ins2
HypersensitivityTnf
HypertensionAbcc8 , Adipoq , Akt2 , Cacna1c , Gck , Ikbkb , Ins2 , Kcnj11 , Mapk8 , Mtor , Pik3r1 , Prkcd , Prkce , Tnf
Hypertension, PortalMtor , Pik3r1 , Prkcd
Hypertension, PulmonaryAdipoq , Hk1 , Mtor , Slc2a4 , Tnf
Hypertension, RenalTnf
HyperthyroidismAdipoq
HypertriglyceridemiaAdipoq , Ins2 , Mtor , Socs1 , Socs3
HypertrophyMapk1 , Mapk3
Hypertrophy, Left VentricularAdipoq , Cacna1g , Kcnj11 , Mtor , Prkcd , Prkcz
Hypertrophy, Right VentricularMtor , Prkcd
HyperuricemiaIns2
HypoadiponectinemiaAdipoq
HypoglycemiaAbcc8 , Akt2 , Cacna1c , Gck , Ins2 , Kcnj11 , Pik3r1 , Tnf
Hypoglycemia, Leucine-InducedAbcc8
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
HypokalemiaIns2
HypotensionIns2 , Tnf
HypothermiaTnf
Idiopathic Dilation CardiomyopathyTnf
Idiopathic Interstitial PneumoniasMtor
Immunodeficiency 14Pik3cd
Immunodeficiency 15Ikbkb
Immunodeficiency 36Pik3r1
Immunologic Deficiency SyndromesCacna1c
Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal DementiaTnf
Infarction, Middle Cerebral ArteryAbcc8 , Ikbkb , Mtor , Tnf
InfectionTnf
Infertility, FemaleMapk1 , Mapk3
InflammationAdipoq , Mtor , Tnf
Inflammatory Bowel Disease 11Adipoq , Tnf
Inflammatory Bowel DiseasesAdipoq , Ikbkb , Tnf
Influenza, HumanTnf
Insulin ResistanceAdipoq , Akt2 , Gck , Ikbkb , Ins2 , Insr , Irs1 , Irs2 , Kcnj11 , Pdx1 , Pik3r1 , Pklr , Prkcd , Prkcz , Slc2a4 , Socs1 , Socs3 , Tnf
InsulinomaIns2 , Slc2a2
Intellectual DisabilityCacna1g
Intervertebral Disc DisplacementTnf
Intestinal NeoplasmsMapk8 , Prkcd
Intracranial AneurysmTnf
Intracranial HemorrhagesTnf
Intrahepatic Cholestasis of PregnancyTnf
IschemiaAkt2 , Mapk9
Ischemic Attack, TransientIkbkb , Tnf
JaundiceAdipoq
Keratitis, HerpeticTnf
Keratoconjunctivitis SiccaTnf
Keratosis, SeborrheicPik3ca
Kidney DiseasesMapk1 , Tnf
Kidney Diseases, CysticIns2
Kidney Failure, ChronicAdipoq , Irs1 , Mtor , Tnf
Kidney NeoplasmsMapk1 , Mapk3
Kidney Reperfusion InjuryAdipoq , Ikbkb , Kcnj11 , Tnf
LabyrinthitisTnf
Lambert-Eaton Myasthenic SyndromeCacna1b
LeishmaniasisTnf
Leishmaniasis, CutaneousTnf
Leishmaniasis, MucocutaneousTnf
Leishmaniasis, VisceralTnf
LeprosyTnf
LeukemiaPrkcz
Leukemia, Lymphocytic, Chronic, B-CellTnf
Leukomalacia, PeriventricularTnf
Lewy Body DiseaseIns2 , Insr
Limb Deformities, CongenitalCacna1c
LipodystrophyInsr
Lipodystrophy, Familial PartialAkt2
ListeriosisTnf
Liver CirrhosisAdipoq
Liver Cirrhosis, AlcoholicTnf
Liver Cirrhosis, ExperimentalAdipoq , Gck , Ins2 , Mtor , Pklr , Prkcd , Socs1 , Socs2 , Tnf
Liver DiseasesHk3 , Socs1 , Socs3 , Tnf
Liver Failure, AcuteIns1 , Ins2 , Mapk8 , Tnf
Liver InjuryGck
Liver NeoplasmsPik3ca , Prkce , Tnf
Liver Neoplasms, ExperimentalSocs1
Liver Reperfusion InjuryAdipoq , Mapk8 , Tnf
Long QT SyndromeCacna1c , Hk3
Low Tension GlaucomaTnf
lung cancerPik3ca
Lung DiseasesInsr , Tnf
Lung Diseases, FungalTnf
Lung InjuryMtor , Tnf
Lung NeoplasmsMapk1 , Mapk3 , Mtor , Pik3ca , Tnf
Lung Reperfusion InjuryTnf
Lupus Erythematosus, SystemicAdipoq , Tnf
Lupus NephritisMtor , Tnf
Lymphatic MetastasisPik3ca , Pik3cb , Socs2 , Socs3
Lymphoma, Large B-Cell, DiffusePik3ca , Pik3cb , Pik3cd
Lymphoma, Mantle-CellMtor , Pik3cd
Lymphoma, Non-HodgkinPik3ca
LymphopeniaTnf
MalariaPklr , Tnf
Malaria, FalciparumTnf
Malformations of Cortical DevelopmentMtor , Pik3ca
Mammary Neoplasms, AnimalPik3r1
Mammary Neoplasms, ExperimentalAdipoq , Akt2 , Mtor , Pik3r1 , Socs1 , Socs3 , Tnf
Manganese PoisoningTnf
Masked HypertensionAdipoq
Maturity-Onset Diabetes of the YoungAbcc8 , Gck , Ins1 , Ins2 , Kcnj11
Maturity-Onset Diabetes of the Young, Type 10Ins1 , Ins2
Maturity-Onset Diabetes of the Young, Type 13Kcnj11
Maturity-Onset Diabetes of the Young, Type 2Gck , Kcnj11
Maturity-Onset Diabetes of the Young, Type 4Pdx1
MedulloblastomaIrs2 , Pik3ca
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca , Pik3r2
MelanomaCacna1c , Mtor , Pik3ca , Pik3r1 , Tnf
Melanoma, ExperimentalIkbkb
Memory DisordersCacna1d , Ins2
Meningitis, PneumococcalTnf
MesotheliomaMtor
Metabolic DiseasesIns2
Metabolic Syndrome XAdipoq , Ins2 , Irs1 , Tnf
MetaplasiaPdx1
Mevalonate Kinase DeficiencyTnf
Micronuclei, Chromosome-DefectiveIns2
Migraine DisordersCacna1a
Migraine with AuraCacna1a
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1Tnf
Migraine without AuraTnf
Migraine, Sporadic HemiplegicCacna1a
Mild Cognitive ImpairmentAdipoq
Mitochondrial MyopathiesTnf
Mixed Connective Tissue DiseaseTnf
Mixed Tumor, MullerianPik3ca , Pik3r1
Mouth NeoplasmsPik3ca
MPTP PoisoningIns2
Mucocutaneous Lymph Node SyndromeAdipoq , Tnf
Multiple MyelomaHk1 , Pik3ca , Tnf
Multiple Organ FailureMapk1 , Tnf
Multiple SclerosisAdipoq , Cacna1b , Tnf
Muscular AtrophyIkbkb , Mtor , Tnf
Muscular DiseasesIns2 , Prkcd
Muscular DystrophiesTnf
Muscular Dystrophy, AnimalMtor
Mycobacterium Avium-Intracellulare InfectionAdipoq , Tnf
Myelodysplastic SyndromesTnf
Myocardial InfarctionAdipoq , Mapk1 , Mtor , Prkce , Socs1 , Tnf
Myocardial IschemiaAdipoq , Hk1 , Hk2 , Kcnj11 , Prkcd , Prkce , Socs3 , Tnf
Myocardial Reperfusion InjuryAbcc8 , Adipoq , Akt2 , Kcnj11 , Mapk1 , Mapk8 , Mapk9 , Prkcd , Slc2a4 , Tnf
Myocardial StunningTnf
MyocarditisAdipoq , Tnf
Myocarditis, Autoimmune, ExperimentalAdipoq
MyositisTnf
NarcolepsySocs2
Nasal PolypsTnf
Nasopharyngeal CarcinomaAkt2 , Pik3ca
Nasopharyngeal NeoplasmsPik3ca
NauseaTnf
NecrosisAbcc8 , Tnf
Nematode InfectionsPik3r1
Neoplasm InvasivenessMapk1 , Mapk3 , Tnf
Neoplasm MetastasisAkt2 , Mapk1 , Mapk3 , Mapk9 , Mtor , Pik3r3 , Tnf
NeoplasmsPik3ca , Pik3r1
Neoplasms, ExperimentalTnf
Neoplastic Syndromes, HereditaryPik3ca
NephritisMtor
Nerve DegenerationMapk1 , Mapk3 , Tnf
Nervous System DiseasesTnf
NesidioblastosisAbcc8 , Kcnj11
Neural Tube DefectsIns2 , Slc2a2
NeuralgiaTnf
Neuritis, Autoimmune, ExperimentalTnf
NeuroblastomaPik3ca
Neurocognitive DisordersIns2
Neurogenic InflammationTnf
Neuropathy, Hereditary Motor and Sensory, Russe TypeHk1
Neuropathy, PainfulTnf
Neurotoxicity SyndromesMtor , Prkcd
NeutropeniaTnf
Non-alcoholic Fatty Liver DiseaseAdipoq , Irs1 , Irs2 , Tnf
ObesityAdipoq , Akt2 , Gck , Hk1 , Hk2 , Ikbkb , Ins2 , Irs1 , Irs2 , Mtor , Pdx1 , Pik3r1 , Pklr , Prkcd , Socs1 , Socs3 , Tnf
Oral Submucous FibrosisTnf
OsteoarthritisIns2 , Mtor
OsteolysisTnf
OsteoporosisIrs1 , Irs2
Osteoporosis, PostmenopausalTnf
Otitis MediaTnf
Otitis Media with EffusionTnf
Ovarian Epithelial CancerPik3ca
Ovarian NeoplasmsAkt2 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1 , Socs1 , Socs2 , Tnf
Oxygen-Induced RetinopathyAdipoq , Mapk8 , Tnf
PainTnf
Pancreatic AdenocarcinomaPik3ca
Pancreatic Agenesis, CongenitalPdx1
Pancreatic CarcinomaMtor
Pancreatic NeoplasmsAkt2 , Ins2 , Mtor , Pdx1 , Tnf
PancreatitisIkbkb , Ins2
Pancreatitis, Acute NecrotizingPdx1
Pancreatitis, Experimental, Acute Tnf
Panic DisorderIns2
papillary renal cell carcinoma Mtor , Pik3ca
Papillary Renal Cell Carcinoma, SporadicMtor , Pik3ca
ParacoccidioidomycosisTnf
ParalysisIns2
ParesthesiaIns2
Parkinson DiseaseIns2 , Insr , Tnf
Parkinsonian DisordersAbcc8 , Kcnj11 , Mtor , Prkcd , Tnf
Paroxysmal ventricular fibrillationCacna1c
Pediatric Crohn's DiseaseTnf
Pemphigoid, Benign Mucous MembraneTnf
Penile NeoplasmsPik3ca
PeriodontitisTnf
Peripheral Arterial DiseaseAdipoq
Peripheral Nerve InjuriesTnf
Peripheral Nervous System DiseasesCacna1b , Prkce
PeritonitisTnf
Picornaviridae InfectionsTnf
Placenta DiseasesTnf
Placental InsufficiencyPdx1
PlasmacytomaTnf
Pleomorphic Xanthoastrocytoma Gck
Pleural EffusionTnf
PleurisyTnf
PneumoniaIkbkb , Tnf
Pneumonia, AspirationTnf
Pneumonia, BacterialTnf
Pneumonia, MycoplasmaTnf
Pneumonia, PneumococcalMapk1 , Mapk3 , Tnf
Pneumonia, ViralTnf
Polychondritis, RelapsingTnf
Polycystic Kidney DiseasesMtor
Polycystic Kidney, Autosomal DominantMtor
Polycystic Kidney, Autosomal RecessiveMtor , Pik3ca
Polycystic Ovary SyndromeAdipoq , Ins2
PolymyositisTnf
Pre-EclampsiaTnf
Precancerous ConditionsInsr , Irs1 , Mapk8 , Mapk9 , Socs4
Precursor Cell Lymphoblastic Leukemia-LymphomaHk1
Precursor T-Cell Lymphoblastic Leukemia-LymphomaMtor
Prediabetic StateKcnj11 , Pdx1
Pregnancy Complications, CardiovascularTnf
PresbycusisCacna1d
Primary Aldosteronism, Seizures, and Neurologic AbnormalitiesCacna1d
Proliferative Diabetic RetinopathyAdipoq
Prostatic NeoplasmsAdipoq , Cacna1d , Ins2 , Insr , Irs1 , Mapk10 , Mapk3 , Mtor , Pik3ca , Pik3cd , Pik3r1 , Prkcz , Socs1 , Tnf
Pseudomonas InfectionsTnf
PsoriasisIkbkb , Tnf
Pulmonary Disease, Chronic ObstructiveAdipoq , Mapk8 , Tnf
Pulmonary EdemaAdipoq , Tnf
Pulmonary EmphysemaAdipoq , Tnf
Pulmonary FibrosisAdipoq , Tnf
Pulmonary Heart DiseaseTnf
Pyruvate Dehydrogenase E3-Binding Protein DeficiencyPdx1
Pyruvate Kinase Deficiency of Red CellsPklr
Radiation Injuries, ExperimentalMapk1 , Mapk3 , Tnf
Radiation PneumonitisTnf
RadiculopathyTnf
Rectal NeoplasmsMapk8 , Pik3ca , Pik3cb
Renal FibrosisMapk1
Renal InsufficiencyIns2
Renal Insufficiency, ChronicInsr
Reperfusion InjuryAdipoq , Mapk8 , Mapk9 , Pik3r1 , Pklr , Socs1 , Socs3 , Socs4 , Tnf
Respiratory Distress Syndrome, AdultTnf
Respiratory HypersensitivityTnf
Respiratory Syncytial Virus InfectionsTnf
Respiratory Tract DiseasesTnf
Respiratory Tract InfectionsTnf
Retina Reperfusion InjuryTnf
Retinal Artery OcclusionTnf
Retinal DetachmentTnf
Retinal DiseasesTnf
Retinal NeovascularizationMtor
RETINITIS PIGMENTOSA 79Hk1
Rett SyndromeAdipoq
RhabdomyolysisIns2
RhinitisTnf
Rhinitis, Allergic, PerennialAdipoq
RhinosinusitisTnf
Sarcoidosis, PulmonaryTnf
SarcomaPik3ca , Tnf
SchizophreniaCacna1c , Mapk3 , Mtor , Pik3cb , Tnf
Sciatic NeuropathyAbcc8 , Cacna1d , Kcnj11 , Mtor , Tnf
ScleritisTnf
Scleroderma, DiffuseAdipoq
Scleroderma, LocalizedTnf
Segawa Syndrome, Autosomal RecessiveIns1 , Ins2
SeizuresAbcc8 , Adipoq , Cacna1a , Ins2 , Kcnj11 , Prkcd , Tnf
SeminomaInsr
SepsisAdipoq , Irs1 , Mapk1 , Mapk3 , Mtor , Socs1 , Socs2 , Socs3 , Tnf
Septic PeritonitisPik3r1
Sezary SyndromeMapk1
ShockTnf
Shock, HemorrhagicMapk1 , Mtor , Tnf
Shock, SepticTnf
Short Bowel SyndromeInsr
Short Qt SyndromeCacna1c
SHORT SyndromePik3r1
SilicosisTnf
Silver-Russell SyndromeIns1
Sinoatrial Node Dysfunction and DeafnessCacna1d
Sjogren's SyndromeTnf
Skin DiseasesTnf
Sleep Apnea SyndromesAdipoq
Sleep Apnea, ObstructiveTnf
Small Cell Lung CarcinomaPik3ca
Smith-Kingsmore SyndromeMtor
Smith-Magenis SyndromeCacna1g , Socs3
Soft Tissue NeoplasmsTnf
Spinal Cord CompressionTnf
Spinal Cord InjuriesAbcc8 , Adipoq , Mtor , Socs2 , Tnf
SPINOCEREBELLAR ATAXIA 42Cacna1g
Spinocerebellar AtaxiasCacna1a
Spondylitis, AnkylosingAdipoq
Spondylocostal Dysostosis 5Mapk3
Squamous Cell Carcinoma of the LungPik3ca
Squamous Cell Carcinoma of the TongueAdipoq
Status EpilepticusAbcc8 , Kcnj11 , Mtor , Socs3 , Tnf
Stevens-Johnson SyndromeTnf
Stomach NeoplasmsIrs2 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Tnf
Stomach UlcerTnf
StrokeAbcc8 , Adipoq , Mapk8 , Prkcd , Tnf
Subarachnoid HemorrhageAbcc8 , Adipoq , Tnf
Subarachnoid Hemorrhage, TraumaticAbcc8
Substance Withdrawal SyndromeMapk1 , Mapk3
Substance-Related DisordersInsr , Prkce
Systemic CandidiasisTnf
TachycardiaIns2 , Tnf
Tachycardia, VentricularCacna1c
Telangiectasia, Hereditary HemorrhagicTnf
Telomeric 22q13 Monosomy SyndromeIns2
Temporomandibular Joint DisordersMtor , Tnf
ThalassemiaTnf
ThrombocytopeniaTnf
ThrombosisPik3cb , Tnf
Thyroid NeoplasmsTnf
Thyroiditis, AutoimmuneTnf
Timothy SyndromeCacna1c
Tongue NeoplasmsTnf
TrachomaTnf
Transplant RejectionIkbkb , Tnf
TrichinellosisTnf
Trigeminal NeuralgiaMapk1 , Mapk3 , Mapk8 , Mapk9 , Tnf
TuberculosisTnf
Tuberculosis, MeningealTnf
Tuberculosis, PulmonaryAdipoq , Tnf
Ureteral ObstructionMtor , Tnf
Urethral ObstructionMapk1
Urinary Bladder DiseasesIns2
Urinary Bladder NeoplasmsHk1 , Mtor , Socs1 , Tnf
Urinary IncontinenceMapk1
UrticariaTnf
Uterine Cervical NeoplasmsMapk1 , Mtor , Pik3ca , Tnf
Uterine NeoplasmsMtor , Pik3ca , Pik3r1
UveitisTnf
Uveitis, AnteriorTnf
Uveitis, IntermediateTnf
Uveomeningoencephalitic SyndromeTnf
Vascular DiseasesAdipoq , Tnf
Vascular MalformationsPik3ca
Vascular System InjuriesTnf
Venous ThromboembolismTnf
Ventricular DysfunctionTnf
Ventricular Dysfunction, LeftIns2
Ventricular FibrillationIns2
Ventricular Fibrillation, Paroxysmal Familial, 1Cacna1c
Ventricular Outflow ObstructionIns2
VitiligoTnf
Vulvar VestibulitisTnf
Weight GainAdipoq , Pik3ca , Tnf
Weight LossAdipoq , Ins2
Weill-Marchesani SyndromeTnf
Wet Macular DegenerationMapk8
Wounds and InjuriesTnf
Wounds, PenetratingTnf
Pathway Annotations Associated with Genes in the type 2 diabetes mellitus pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
acute myeloid leukemia pathwayAkt2 , Ikbkb , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
adenosine signaling pathwayIkbkb , Mapk1 , Mapk8 , Pik3ca , Prkcz
adiponectin signaling pathwayAdipoq
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
aldosterone signaling pathwayIns1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
alfentanil pharmacodynamics pathwayCacna1a
allograft rejection pathwayTnf
altered galactose metabolic pathwayHk2
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered insulin secretion pathwayAbcc8 , Kcnj11
altered insulin signaling pathwayIns2 , Insr
altered leptin system pathwayInsr
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt2 , Pik3ca
Alzheimer disease pathwayCacna1c , Cacna1d , Mapk1 , Mapk3 , Tnf
amino sugar metabolic pathwayGck , Hk1 , Hk2 , Hk3
amiodarone pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
amlodipine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
amyotrophic lateral sclerosis disease pathwayTnf
angiotensin II signaling pathwayPrkcz
antigen processing and presentation pathwayTnf
apoptotic cell death pathwayAkt2 , Ikbkb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tnf
arrhythmogenic right ventricular cardiomyopathy pathwayCacna1c , Cacna1d
asthma disease pathwayTnf
atenolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
autophagy pathwayIns1 , Ins2
B cell receptor signaling pathwayAkt2 , Ikbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
betaxolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
bisoprolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
bladder cancer pathwayMapk1 , Mapk3
Bone morphogenetic proteins signaling pathwayMapk1
bupivacaine pharmacodynamics pathwayCacna1a
bupranolol drug pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
bupranolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
buprenorphine pharmacodynamics pathwayCacna1a
butirosin and neomycin biosynthetic pathwayGck , Hk1 , Hk2 , Hk3
c-Jun N-terminal kinases MAPK signaling pathwayMapk10 , Mapk8 , Mapk9
calcium transport pathwayCacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1g
calcium/calcium-mediated signaling pathwayCacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1g
calcium/calmodulin dependent kinase 2 signaling pathwayCacna1c
carvedilol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
ceramide signaling pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd , Prkcz , Tnf
chemokine mediated signaling pathwayAkt2 , Ikbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd , Prkcz
chloroprocaine pharmacodynamics pathwayCacna1a
chronic myeloid leukemia pathwayAkt2 , Ikbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
citalopram pharmacodynamics pathwayCacna1a
cocaine pharmacodynamics pathwayCacna1a
codeine and morphine pharmacodynamics pathwayCacna1a
colorectal cancer pathwayAkt2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
cytokine mediated signaling pathwayTnf
desipramine pharmacodynamics pathwayCacna1a
diabetes pathwayAbcc8
dilated cardiomyopathy pathwayCacna1c , Cacna1d , Tnf
diltiazem pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
diphenoxylate pharmacodynamics pathwayCacna1a
disopyramide pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
dobutamine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
E-cadherin signaling pathwayAkt2 , Pik3ca , Pik3r1
eicosanoid signaling pathwayPik3r5 , Prkcd , Prkce , Prkcz
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaAdipoq
endocytosis pathwayPrkcz
endometrial cancer pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Endoplasmic Reticulum-associated degradation pathwayMapk10 , Mapk8 , Mapk9
endothelin signaling pathwayMapk1 , Mapk3 , Mapk8 , Prkcd , Prkce
Entamoeba histolyca infection pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tnf
ephrin - ephrin receptor bidirectional signaling axisMapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1 , Pik3r5
epidermal growth factor/neuregulin signaling pathwayAkt2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcz
erythropoietin signaling pathwayIrs2 , Mapk8 , Pik3r1 , Socs3
escitalopram pharmacodynamics pathwayCacna1a
esmolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
ethylmorphine pharmacodynamics pathwayCacna1a
facilitative sugar transporter mediated glucose transport pathwaySlc2a2 , Slc2a4
fanconi syndrome pathwayHk2 , Pklr , Slc2a2
FasL mediated signaling pathwayIkbkb , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd , Prkce , Tnf
Fc gamma receptor mediated signaling pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd , Prkce
felodipine pharmacokinetics pathwayCacna1c
fentanyl pharmacodynamics pathwayCacna1a
fibroblast growth factor signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3r1
flecainde pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
fluoxetine pharmacodynamics pathwayCacna1a
forkhead class A signaling pathwayAbcc8 , Gck , Ins2 , Kcnj11 , Pdx1 , Pklr , Slc2a2
fosphenytoin pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
french type sialuria disease pathwayHk1
fructose and mannose metabolic pathwayHk1 , Hk2 , Hk3
fructose intolerance pathwayHk1
fructose-1,6-diphosphatase deficiency pathwayHk2 , Slc2a2
fructosuria disease pathwayHk1
galactose metabolic pathwayGck , Hk1 , Hk2 , Hk3
GALE deficiency pathwayGck
GALK deficiency pathwayGck
GALT deficiency pathwayGck , Hk1
gliclazide pharmacodynamics pathwayAbcc8 , Cacna1a , Ins2 , Slc2a2
glioma pathwayAkt2 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
gluconeogenesis pathwayGck , Hk1 , Hk2 , Hk3 , Pklr , Slc2a2
glutamate signaling pathwayCacna1a , Cacna1c , Cacna1d , Mapk1 , Mapk3
glyburide pharmacodynamics pathwayAbcc8 , Cacna1a , Ins2 , Slc2a2
glycogen biosynthetic pathwayGck
glycogen metabolic pathwayGck
glycogen storage disease pathway, type IAHk2 , Slc2a2
glycogen storage disease pathway, type IBHk2 , Slc2a2
glycogen storage disease pathway, type IIIGck , Hk2
glycogen storage disease pathway, type IV.Gck , Hk2
glycogen storage disease pathway, type VIGck , Hk2
glycogen storage disease pathway, type VIIHk2 , Pklr , Slc2a2
glycolysis pathwayGck , Hk1 , Hk2 , Hk3 , Pklr , Slc2a2
glycolysis/gluconeogenesis pathwayGck , Hk1 , Hk2 , Hk3 , Pklr
glypican signaling pathwayMapk8 , Mapk9
gonadotropin-releasing hormone signaling pathwayCacna1c , Cacna1d , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Prkcd
graft-versus-host disease pathwayTnf
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Mapk1 , Mapk3 , Pik3ca , Pik3r1
Hedgehog signaling pathwayPik3ca , Pik3r1 , Prkcd
hepatitis C virus infection pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs3 , Tnf
heroin pharmacodynamics pathwayCacna1a
hydrocodone pharmacodynamics pathwayCacna1a
hydromorphone pharmacodynamics pathwayCacna1a
hypertrophic cardiomyopathy pathwayCacna1c , Cacna1d , Tnf
hypoxia inducible factor pathwayGck , Hk1 , Hk2
ibutilide pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
imipramine pharmacodynamics pathwayCacna1a
inflammatory response pathwayMapk8
influenza A virus infection pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs3 , Tnf
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2 , Ins2 , Insr , Prkcz , Slc2a4
insulin secretion pathwayAbcc8 , Cacna1a , Cacna1c , Cacna1d , Gck , Kcnj11 , Slc2a2
insulin signaling pathwayAkt2 , Gck , Hk1 , Hk2 , Hk3 , Ikbkb , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pklr , Prkcz , Slc2a4 , Socs1 , Socs2 , Socs3 , Socs4
insulin-like growth factor signaling pathwayIrs1 , Irs2 , Irs4 , Pik3ca , Pik3r1 , Prkcd , Prkcz
interleukin-1 signaling pathwayIkbkb , Mapk8 , Pik3ca , Pik3r1 , Prkcz
interleukin-12 signaling pathwayMtor , Socs1
interleukin-2 signaling pathwayIrs1 , Irs2 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3r1 , Prkce , Socs1 , Socs2 , Socs3
interleukin-23 signaling pathwayPik3ca , Pik3r1 , Socs3 , Tnf
interleukin-27 signaling pathwayTnf
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayIrs1 , Irs2 , Mtor , Pik3ca , Pik3r1 , Socs1 , Socs3
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayPik3ca , Pik3r1 , Prkcd , Socs3
isoprenaline pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
isradipine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
Jak-Stat signaling pathwayAkt2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs1 , Socs2 , Socs3 , Socs4
lactose degradation pathwaySlc2a2
Leigh syndrome pathwayPklr
Leishmania infection pathwayMapk1 , Mapk3 , Tnf
leptin system pathwayIrs1 , Irs2 , Socs3
levacetylmethadol pharmacodynamics pathwayCacna1a
levobunolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
levobupivacaine phgarmacodynamics pathwayCacna1a
levorphanol pharmacodynamics pathwayCacna1a
lidocaine pharmacodynamics pathwayAbcc8 , Cacna1a , Cacna1c , Cacna1g , Kcnj11
long term depressionCacna1a , Mapk1 , Mapk3
long term potentiationCacna1c , Mapk1 , Mapk3
maturity onset diabetes of the young pathwayGck , Ins1 , Ins2 , Mafa , Pdx1 , Pklr , Slc2a2
measles infection pathwayAkt2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
melanoma pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
mepivacaine pharmacodynamics pathwayCacna1a
methadone pharmacodynamics pathwayCacna1a
metoprolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
mexiletine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
mitogen activated protein kinase signaling pathwayAkt2 , Cacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1g , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Tnf
mTOR signaling pathwayAkt2 , Ikbkb , Ins1 , Ins2 , Irs1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Mycobacterium tuberculosis infection pathwayAkt2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Tnf
N-cadherin signaling pathwayMapk8 , Pik3ca , Pik3r1
nadolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
nalbuphine pharmacodynamics pathwayCacna1a
naloxone pharmacodynamics pathwayCacna1a
naltrexone pharmacodynamics pathwayCacna1a
nebivolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
neurotrophic factor signaling pathwayAkt2 , Ikbkb , Irs1 , Irs2 , Irs3 , Irs4 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd
nicotine pharmacodynamics pathwayCacna1a
nifedipine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
nimodipine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
nisoldipine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
nitrendipine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
NOD-like receptor signaling pathwayIkbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Tnf
non-small cell lung cancer pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
nuclear factor kappa B signaling pathwayIkbkb , Pik3ca , Pik3r1 , Tnf
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb
nucleotide sugar metabolic pathwayGck , Hk1 , Hk2 , Hk3
oxybuprocaine pharmacodynamics pathwayCacna1a
oxycodone pharmacodynamics pathwayCacna1a
oxymorphone pharmacodynamics pathwayCacna1a
p53 signaling pathwayMapk8 , Mapk9 , Prkcd
pancreatic cancer pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
penbutolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
pentazocine pharmacodynamics pathwayCacna1a
phenytoin pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt2 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Slc2a4
phosphoenolpyruvate carboxykinase deficiency pathwayHk2 , Slc2a2
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
pindolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
Plasmodium infection pathwayTnf
platelet-derived growth factor signaling pathwayMapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd , Prkce
potassium channel inhibitors pharmacodynamics pathwayAbcc8 , Cacna1a , Ins2 , Slc2a2
prilocaine pharmacodynamics pathwayCacna1a
primary hyperoxaluria type 2 disease pathwayPklr
prion diseases pathwayMapk1 , Mapk3
procainamide pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
procaine pharmacodynamics pathwayCacna1a
propranolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
prostate cancer pathwayAkt2 , Ikbkb , Ins1 , Ins2 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
protein kinase C (PKC) signaling pathwayPrkcd , Prkce , Prkcz
purine metabolic pathwayPklr
pyruvate dehydrogenase complex deficiency pathwayPklr
pyruvate dehydrogenase E1 deficiency pathwayPklr
pyruvate kinase deficiency pathwayPklr
pyruvate metabolic pathwayPklr
quinidine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
Reelin signaling pathwayMapk8 , Pik3ca , Pik3r1
remifentanil pharmacodynamics pathwayCacna1a
renal cell cancer pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayIkbkb , Mapk10 , Mapk8 , Mapk9 , Tnf
rheumatoid arthritis disease pathwayTnf
Rho/Rac/Cdc42 mediated signaling pathwayMapk8
ropivacaine pharmacodynamics pathwayCacna1a
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
sialic acid storage disease pathwayHk1
small cell lung cancer pathwayAkt2 , Ikbkb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
sotalol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
sphingosine 1-phosphate signaling pathwayIrs1 , Mapk1 , Mapk3 , Mapk8
starch and sucrose metabolic pathwayGck , Hk1 , Hk2 , Hk3
Sucrase-isomaltase deficiency pathwayGck , Hk2
syndecan signaling pathwayMapk1 , Mapk3 , Mapk8 , Prkcd
systemic lupus erythematosus pathwayTnf
T cell receptor signaling pathwayAkt2 , Ikbkb , Mapk1 , Mapk3 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tnf
Tay-Sachs disease pathwayHk1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMapk1 , Mapk3 , Prkcd
thyroid cancer pathwayMapk1 , Mapk3
timolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
Toll-like receptor signaling pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tnf
Toxoplasma gondii infection pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs1 , Tnf
Trail mediated signaling pathwayIkbkb , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
tramadol pharmacodynamics pathwayCacna1a
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Tnf
trehalose degradation pathwayGck , Slc2a2
triosephosphate isomerase deficiency pathwayHk2 , Slc2a2
Trypanosoma brucei infection pathwayTnf
Trypanosoma cruzi infection pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tnf
tumor necrosis factor mediated signaling pathwayIkbkb , Prkcz , Tnf
type 1 diabetes mellitus pathwayIns1 , Ins2 , Tnf
type 2 diabetes mellitus pathwayAbcc8 , Adipoq , Akt2 , Cacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1g , Gck , Hk1 , Hk2 , Hk3 , Ikbkb , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Kcnj11 , Mafa , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Pdx1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pklr , Prkcd , Prkce , Prkcz , Slc2a2 , Slc2a4 , Socs1 , Socs2 , Socs3 , Socs4 , Tnf
type II interferon signaling pathwayMapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1 , Prkcd , Socs1
ubiquitin/proteasome degradation pathwaySocs1 , Socs3
vascular endothelial growth factor signaling pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd , Prkcz
verapamil pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
Wnt signaling pathwayMapk10 , Mapk8 , Mapk9
Wnt signaling, non-canonical pathwayMapk10 , Mapk8 , Mapk9 , Prkcz
Phenotype Annotations Associated with Genes in the type 2 diabetes mellitus pathway

References Associated with the type 2 diabetes mellitus pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: