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Pathways
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NOTCH SIGNALING PATHWAY (PW:0000204)

View Ontology Report

Description
Notch signaling, a highly conserved cell-cell signaling pathway, exerts an essential regulatory role in gene expression and controls cell fate determination, differentiation, and proliferation. Notch receptors and ligands, four and five respectively in mammals, are single transmembrane proteins connecting the cell-receiving and the cell-sending signal. The DSL domain of Dll/Jag ligands and the EGF-like repeats of Notch receptors mediate the interaction. The journey of Notch from transmembrane re

Pathway Diagram:

Ariadne Genomics Inc. Jag_ligands ---- Notch_receptors Jag_ligands Hey ---> regulation of transcription Maml Fng Rbpj ---> Hey Rbpj ---> Hes Hey Hes Rbpj gamma-convertase Notch_receptors Dll_ligands NICD gamma-convertase --+> Notch_receptors Notch_receptors ---> NICD Dll_ligands ---- Notch_receptors Adam10 --+> Notch_receptors Adam17 --+> Notch_receptors Fng --+> Notch_receptors Pofut1 --+> Notch_receptors Hes ---> regulation of transcription regulation of transcription Adam10 Adam17 Pofut1
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Genes in Pathway:
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Notch signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 ISS
ISO		 PID
RGD		 PMID:12354787 PMID:17761886 PID:200015, RGD:1300252, RGD:2302204 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Adam12 ADAM metallopeptidase domain 12 ISO PID PID:200015 NCBI chr 1:188,686,984...189,014,206
Ensembl chr 1:188,686,989...189,020,667 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 ISO
IEA		 KEGG
RGD		 PMID:17761886 rno:04330, RGD:2302204 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit ISO
IEA		 KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 2:183,437,676...183,443,113
Ensembl chr 2:183,438,434...183,441,955 		JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit ISO
IEA		 KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243 		JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200015 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Ccnd1 cyclin D1 ISO PID PID:200015 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO PID PID:200015 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cir1 corepressor interacting with RBPJ, 1 IEA KEGG rno:04330 NCBI chr 3:58,158,923...58,188,799
Ensembl chr 3:58,158,951...58,188,789 		JBrowse link
G Cntn1 contactin 1 ISO PID PID:200015 NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541 		JBrowse link
G Cntn6 contactin 6 ISO PID PID:200015 NCBI chr 4:137,354,886...137,751,712
Ensembl chr 4:137,355,367...137,751,119 		JBrowse link
G Crebbp CREB binding protein IEA KEGG rno:04330 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Ctbp1 C-terminal binding protein 1 ISO
IEA		 PID
KEGG		 PID:200015 rno:04330 NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821 		JBrowse link
G Ctbp2 C-terminal binding protein 2 IEA KEGG rno:04330 NCBI chr 1:187,782,064...187,918,115
Ensembl chr 1:187,782,682...187,920,222 		JBrowse link
G Cul1 cullin 1 ISO PID PID:200015 NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 ISO PID PID:200015 NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522 		JBrowse link
G Dll1 delta like canonical Notch ligand 1 TAS
IEA
ISO		 KEGG
PID
RGD		 PMID:14743446 PMID:17761886 PID:200015 rno:04330, RGD:1304491, RGD:2302204 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179 		JBrowse link
G Dll3 delta like canonical Notch ligand 3 TAS
IEA
ISO		 KEGG
PID
RGD		 PMID:14743446 PMID:17761886 PID:200015 rno:04330, RGD:1304491, RGD:2302204 NCBI chr 1:83,562,011...83,570,008
Ensembl chr 1:83,562,014...83,569,750 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 ISO
IEA		 KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931 		JBrowse link
G Dner delta/notch-like EGF repeat containing ISO PID PID:200015 NCBI chr 9:85,586,985...85,902,461
Ensembl chr 9:85,586,987...85,902,637 		JBrowse link
G Dnm1 dynamin 1 ISO PID PID:200015 NCBI chr 3:15,604,782...15,648,654
Ensembl chr 3:15,604,784...15,648,538 		JBrowse link
G Dtx1 deltex E3 ubiquitin ligase 1 ISO PID PID:200015 NCBI chr12:35,849,647...35,880,835
Ensembl chr12:35,849,617...35,880,838 		JBrowse link
G Dtx2 deltex E3 ubiquitin ligase 2 IEA KEGG rno:04330 NCBI chr12:20,643,289...20,682,908
Ensembl chr12:20,643,297...20,682,885 		JBrowse link
G Dtx3 deltex E3 ubiquitin ligase 3 IEA KEGG rno:04330 NCBI chr 7:63,013,769...63,018,431
Ensembl chr 7:63,013,371...63,018,522 		JBrowse link
G Dtx3l deltex E3 ubiquitin ligase 3L IEA KEGG rno:04330 NCBI chr11:64,814,926...64,824,539
Ensembl chr11:64,814,926...64,824,538 		JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 IEA KEGG rno:04330 NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818 		JBrowse link
G Dvl1 dishevelled segment polarity protein 1 IEA KEGG rno:04330 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664 		JBrowse link
G Dvl3 dishevelled segment polarity protein 3 IEA KEGG rno:04330 NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462 		JBrowse link
G Eno1 enolase 1 ISO PID PID:200015 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Ep300 E1A binding protein p300 ISO
IEA		 PID
KEGG		 PID:200015 rno:04330 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 ISO PID PID:200015 NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 ISO PID PID:200015 NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) ISO PID PID:200015 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314 		JBrowse link
G Gata3 GATA binding protein 3 ISO PID PID:200015 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Hdac1 histone deacetylase 1 ISO
IEA		 PID
KEGG		 PID:200015 rno:04330 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac1l histone deacetylase 1-like IEA KEGG rno:04330 NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593 		JBrowse link
G Hdac2 histone deacetylase 2 IEA KEGG rno:04330 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO
IEA		 KEGG
RGD		 PMID:17586813 rno:04330, RGD:5135539 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hes5 hes family bHLH transcription factor 5 ISO
IEA		 KEGG
RGD		 PMID:17586813 rno:04330, RGD:5135539 NCBI chr 5:165,522,138...165,523,684
Ensembl chr 5:165,522,234...165,523,001 		JBrowse link
G Hes7 hes family bHLH transcription factor 7 ISO RGD PMID:17586813 RGD:5135539 NCBI chr10:53,824,124...53,828,934
Ensembl chr10:53,825,574...53,828,097 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 IDA
ISO		 RGD PMID:11741889 PMID:17586813 RGD:70528, RGD:5135539 NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 ISO
IDA		 RGD PMID:17586813 PMID:11741889 RGD:5135539, RGD:70528 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Heyl hes-related family bHLH transcription factor with YRPW motif-like ISO RGD PMID:17586813 RGD:5135539 NCBI chr 5:135,508,160...135,525,152
Ensembl chr 5:135,508,160...135,525,152 		JBrowse link
G Il4 interleukin 4 ISO PID PID:200015 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO PID PID:200015 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 IDA
IEA
ISO
IMP		 KEGG
PID
RGD		 PMID:7697721 PMID:15057910 PMID:17761886 PID:200015 rno:04330, RGD:69863, RGD:1334443, RGD:2302204 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Jag2 jagged canonical Notch ligand 2 TAS
IEA
ISO		 KEGG
PID
RGD		 PMID:8948600 PMID:17761886 PID:200015 rno:04330, RGD:69864, RGD:2302204 NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818 		JBrowse link
G Kat2a lysine acetyltransferase 2A IEA KEGG rno:04330 NCBI chr10:85,632,216...85,640,561
Ensembl chr10:85,632,216...85,640,166 		JBrowse link
G Kat2b lysine acetyltransferase 2B IEA KEGG rno:04330 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064 		JBrowse link
G Kdm1a lysine demethylase 1A ISO PID PID:200015 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase IDA
IEA
ISO		 KEGG
RGD		 PMID:12167404 PMID:17761886 rno:04330, RGD:727405, RGD:2302204 NCBI chr12:14,030,551...14,038,996
Ensembl chr12:14,018,333...14,039,008 		JBrowse link
G Lnx1 ligand of numb-protein X 1 ISO PID PID:200015 NCBI chr14:33,514,429...33,617,086
Ensembl chr14:33,514,436...33,617,086 		JBrowse link
G Maml1 mastermind-like transcriptional coactivator 1 ISO
IEA		 KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr10:34,588,639...34,623,024
Ensembl chr10:34,588,646...34,623,338 		JBrowse link
G Maml2 mastermind-like transcriptional coactivator 2 ISO
IEA		 KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 8:10,268,611...10,588,307
Ensembl chr 8:10,268,665...10,587,107 		JBrowse link
G Maml3 mastermind-like transcriptional coactivator 3 ISO RGD PMID:17761886 RGD:2302204 NCBI chr 2:135,720,431...136,137,829
Ensembl chr 2:135,721,021...136,137,814 		JBrowse link
G Mark2 microtubule affinity regulating kinase 2 ISO PID PID:200015 NCBI chr 1:204,461,029...204,526,247
Ensembl chr 1:204,461,030...204,525,652 		JBrowse link
G Mfap2 microfibril associated protein 2 ISO PID PID:200015 NCBI chr 5:153,312,068...153,320,266
Ensembl chr 5:153,314,711...153,320,259 		JBrowse link
G Mfap5 microfibril associated protein 5 ISO PID PID:200015 NCBI chr 4:155,727,925...155,750,458
Ensembl chr 4:155,727,925...155,750,458 		JBrowse link
G Mfng MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ISS
IEA
ISO		 KEGG
RGD		 PMID:9187150 PMID:17761886 rno:04330, RGD:1302739, RGD:2302204 NCBI chr 7:110,310,810...110,328,653
Ensembl chr 7:110,310,812...110,328,653 		JBrowse link
G Mib1 MIB E3 ubiquitin protein ligase 1 ISO PID
RGD		 PMID:12530964 PID:200015, RGD:1334454 NCBI chr18:1,802,519...1,926,988
Ensembl chr18:1,802,519...1,920,689 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO PID PID:200015 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Mycbp Myc binding protein ISO PID PID:200015 NCBI chr 5:136,135,955...136,143,163
Ensembl chr 5:136,135,931...136,145,616 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 ISO PID PID:200015 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 ISO
IEA		 PID
KEGG		 PID:200015 rno:04330 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Ncstn nicastrin TAS
IEA
ISO		 KEGG
PID
RGD		 PMID:12736250 PMID:17761886 PID:200015 rno:04330, RGD:724403, RGD:2302204 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Neurl1 neuralized E3 ubiquitin protein ligase 1 ISO RGD PMID:14986688 RGD:1334462 NCBI chr 1:246,066,830...246,152,890
Ensembl chr 1:246,067,100...246,152,903 		JBrowse link
G Neurl2 neuralized E3 ubiquitin protein ligase 2 ISO RGD PMID:14986688 RGD:1334462 NCBI chr 3:153,566,659...153,569,380
Ensembl chr 3:153,566,660...153,569,380 		JBrowse link
G Notch1 notch receptor 1 IDA
IEA
ISO
IMP		 KEGG
PID
RGD		 PMID:11900468 PMID:15247148 PMID:15057910 PMID:17761886 PMID:12853432 PID:200015 rno:04330, RGD:724389, RGD:2306423, RGD:1334443, RGD:2302204, RGD:1358543 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Notch2 notch receptor 2 TAS
IEA
ISO		 KEGG
PID
RGD		 PMID:1295745 PMID:17761886 PID:200015 rno:04330, RGD:69906, RGD:2302204 NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088 		JBrowse link
G Notch3 notch receptor 3 IDA
IEA
ISO		 KEGG
PID
RGD		 PMID:11971902 PMID:15247148 PMID:17761886 PID:200015 rno:04330, RGD:625426, RGD:2306423, RGD:2302204 NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025 		JBrowse link
G Notch4 notch receptor 4 IDA
IEA
ISO		 KEGG
PID
RGD		 PMID:10964583 PMID:17761886 PID:200015 rno:04330, RGD:1304484, RGD:2302204 NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465 		JBrowse link
G Numb NUMB, endocytic adaptor protein TAS
IEA
ISO		 KEGG
PID
RGD		 PMID:12500307 PID:200015 rno:04330, RGD:724390 NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354 		JBrowse link
G Numbl NUMB-like, endocytic adaptor protein ISO
IEA		 KEGG
RGD		 PMID:15492044 rno:04330, RGD:1334451 NCBI chr 1:82,549,814...82,573,788
Ensembl chr 1:82,550,054...82,573,776 		JBrowse link
G Pofut1 protein O-fucosyltransferase 1 ISS
ISO		 RGD PMID:14570055 PMID:17761886 RGD:1334453, RGD:2302204 NCBI chr 3:141,708,618...141,735,558
Ensembl chr 3:141,708,644...141,734,786 		JBrowse link
G Psen1 presenilin 1 TAS
IEA
ISO		 KEGG
PID
RGD		 PMID:12736250 PMID:17761886 PID:200015 rno:04330, RGD:724403, RGD:2302204 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 ISO
IEA		 KEGG
RGD		 PMID:17761886 rno:04330, RGD:2302204 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Psenen presenilin enhancer gamma secretase subunit ISO
IEA		 KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192 		JBrowse link
G Ptcra pre T-cell antigen receptor alpha IEA KEGG rno:04330 NCBI chr 9:14,218,907...14,229,141
Ensembl chr 9:14,218,802...14,229,235 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family ISO PID PID:200015 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease ISO PID PID:200015 NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region IDA
IEA
ISO		 KEGG
PID
RGD		 PMID:15247148 PID:200015 rno:04330, RGD:2306423 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
G Rbpjl recombination signal binding protein for immunoglobulin kappa J region-like IEA KEGG rno:04330 NCBI chr 3:153,134,044...153,147,421
Ensembl chr 3:153,134,140...153,146,513 		JBrowse link
G Rbpjl2 recombination signal binding protein for immunoglobulin kappa J region-like 2 IEA KEGG rno:04330 NCBI chr 5:5,464,969...5,466,367
Ensembl chr 5:5,464,397...5,466,366 		JBrowse link
G Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase IMP
IEA
ISO		 KEGG
RGD		 PMID:11165380 PMID:17761886 rno:04330, RGD:633801, RGD:2302204 NCBI chr10:106,047,221...106,050,331
Ensembl chr10:106,047,221...106,050,345 		JBrowse link
G Skp1 S-phase kinase-associated protein 1 ISO PID PID:200015 NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388 		JBrowse link
G Skp2 S-phase kinase associated protein 2 ISO PID PID:200015 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Snw1 SNW domain containing 1 IEA KEGG rno:04330 NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536 		JBrowse link
G Spen spen family transcriptional repressor ISO PID PID:200015 NCBI chr 5:153,775,287...153,848,677
Ensembl chr 5:153,776,234...153,848,811 		JBrowse link
G Sspo SCO-spondin ISO PID PID:200015 NCBI chr 4:77,394,915...77,450,526
Ensembl chr 4:77,397,059...77,450,412 		JBrowse link
G Yy1 YY1 transcription factor ISO PID PID:200015 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
altered Notch signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 ISS paper on the human protein which may be involved in disease RGD PMID:10079256 RGD:1304492 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179 		JBrowse link
G Dll3 delta like canonical Notch ligand 3 ISS paper mentions mutations and diseases, deletion in mice RGD PMID:12141422 RGD:1304493 NCBI chr 1:83,562,011...83,570,008
Ensembl chr 1:83,562,014...83,569,750 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISS RGD PMID:12548545 RGD:1334460 NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISS RGD PMID:10964583 RGD:1304484 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Jag2 jagged canonical Notch ligand 2 ISS RGD PMID:10079256 RGD:1304492 NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818 		JBrowse link
G Notch1 notch receptor 1 ISS RGD PMID:11900468 RGD:724389 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Notch4 notch receptor 4 ISS RGD PMID:10964583 RGD:1304484 NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465 		JBrowse link
G Numb NUMB, endocytic adaptor protein ISS RGD PMID:15492044 RGD:1334451 NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354 		JBrowse link
G Pofut1 protein O-fucosyltransferase 1 ISS RGD PMID:14570055 RGD:1334453 NCBI chr 3:141,708,618...141,735,558
Ensembl chr 3:141,708,644...141,734,786 		JBrowse link
altered Notch signaling pathway involving promoters term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISS RGD PMID:12548545 RGD:1334460 NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
altered Notch signaling pathway involving the macromolecules modifying the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Numb NUMB, endocytic adaptor protein ISS In humans, loss of Numb regulation over Notch is involved in breast cancer. RGD PMID:15492044 RGD:1334451 NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354 		JBrowse link
G Pofut1 protein O-fucosyltransferase 1 ISS RGD PMID:14570055 RGD:1334453 NCBI chr 3:141,708,618...141,735,558
Ensembl chr 3:141,708,644...141,734,786 		JBrowse link
G Psen2 presenilin 2 ISO C. elegans transgenics expressing human wild-type and mutant PSEN2 RGD PMID:16474849 RGD:2302525 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
altered Notch signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll3 delta like canonical Notch ligand 3 ISS RGD PMID:12141422 RGD:1304493 NCBI chr 1:83,562,011...83,570,008
Ensembl chr 1:83,562,014...83,569,750 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISS RGD PMID:15057910 RGD:1334443 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Notch1 notch receptor 1 ISS RGD PMID:15472075 RGD:1334450 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Notch3 notch receptor 3 ISS RGD PMID:14667809 RGD:1334442 NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025 		JBrowse link

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Complexgamma-convertasea multiprotein protease complex containing Psen1 or 2, Aph1, Ncstn and Psenen
Functional ClassDll_ligandsdelta-like Notch ligands
Functional ClassFngfringe 3-beta-N-acetylglucosaminyltransferase members
Functional ClassJag_ligandsJagged Notch ligands
Functional ClassMamlmastermind-like family members
Functional ClassNotch_receptorsNotch family members

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Notch signaling pathway
Disease TermsGene Symbols
3-Hydroxy-3-Methylglutaryl-CoA Lyase DeficiencyKdm1a
3-Methylcrotonyl-CoA carboxylase 1 deficiencyDvl3
3p deletion syndromeKat2b
Aberrant Crypt FociMyc
acoustic neuromaCdkn1a
Acroosteolysis Dominant TypeNotch2
Acute Coronary SyndromeEno1
Acute Experimental PancreatitisCdkn1a , Il4
Acute HepatitisIl4
acute kidney failureDll4 , Hdac2 , Hes1 , Myc
Acute Lung InjuryIl4
acute lymphoblastic leukemiaCcnd1 , Crebbp , Gata3 , Hdac1 , Hdac2 , Myc
acute myeloid leukemiaCbl , Ccnd1 , Crebbp , Myc
acute myocardial infarctionIl4
acute promyelocytic leukemiaMyc
Acute-Phase ReactionNcor1
Adams-Oliver syndromeDll4 , Notch1 , Rbpj
Adams-Oliver Syndrome 2Notch1
Adams-Oliver Syndrome 3Rbpj
Adams-Oliver Syndrome 5Notch1
Adams-Oliver Syndrome 6Dll4
adenocarcinomaCcnd1 , Eno1 , Myc
adenoid cystic carcinomaCcnd1 , Cntn6 , Crebbp , Dtx4 , Ep300 , Fbxw7 , Jag1 , Maml3 , Mark2 , Mycbp , Notch1
adenoiditisNotch1
adenylosuccinase lyase deficiencyEp300 , Mfng
adult T-cell leukemia/lymphomaGata3 , Il4 , Notch1
Agenesis of Corpus CallosumCrebbp , Ep300
Aicardi-Goutieres Syndrome 3Ccnd1
AIDS-Associated NephropathyNotch4
Alagille syndromeJag1 , Notch2
ALAGILLE SYNDROME 1Jag1
ALAGILLE SYNDROME 2Notch2
alcohol use disorderCrebbp , Ep300 , Hdac2
Alcoholic Liver DiseasesMyc
alkaptonuriaDtx3l
allergic contact dermatitisIl4
allergic diseaseIl4
allergic rhinitisIl4
alopecia areataHdac1 , Hdac2 , Kdm1a , Notch4
alopecia universalisIl4
Alzheimer's diseaseAdam10 , Adam17 , Aph1a , Aph1b , Crebbp , Dnm1 , Eno1 , Ep300 , Hdac2 , Il4 , Ncstn , Psen1 , Psen2
Alzheimer's disease 18Adam10
Alzheimer's disease 3Psen1
Alzheimer's disease 4Psen1 , Psen2
Alzheimer's Disease, Familial, 3, with Spastic ParaparesisPsen1
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and ApraxiaPsen1
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Unusual PlaquesPsen1
Amyloid NeuropathiesPsen1
Amyloid PlaquesPsen1
amyloidosisPsen1
amyotrophic lateral sclerosisHes1 , Hey1 , Jag1 , Maml1 , Notch1
amyotrophic lateral sclerosis type 1Crebbp
AnaphylaxisIl4
angiosarcomaCcnd1 , Myc
Animal Disease ModelsEno1 , Myc , Psen1
Animal Mammary NeoplasmsCcnd1 , Cdkn1a , Eno1 , Furin , Gata3 , Notch4
anogenital venereal wartIl4
anti-basement membrane glomerulonephritisIl4
anxiety disorderHdac2 , Ncor1
aortic aneurysmJag1
Aortic CoarctationJag1
aortic valve diseaseHey2 , Notch1 , Rbpj
aortic valve disease 1Notch1
Arsenic PoisoningCdkn1a
ARTERIAL DISSECTIONNotch1
arteriosclerosisFurin , Notch4
arteriovenous malformations of the brainNotch4
asphyxia neonatorumPsen1 , Psen2
aspirin-induced respiratory diseaseIl4
asthmaGata3 , Hdac2 , Il4
AtaxiaCntn1
ataxia telangiectasiaMaml2
atherosclerosisCcnd1 , Dll4 , Hey1 , Myc , Notch1
atopic dermatitisAdam17 , Il4
atrial fibrillationCdkn1a , Neurl1
atrial heart septal defectCrebbp
Atrioventricular Septal Defect 5Mib1
Au-Kline SyndromeCrebbp
Auditory NeuropathyNotch3
autism spectrum disorderCntn6 , Crebbp , Hey1 , Jag1 , Mib1 , Notch1 , Notch2 , Notch3 , Notch4 , Spen
autistic disorderCntn6 , Il4 , Mark2 , Ncor1
autoimmune diseaseIl4
autoimmune hepatitisIl4
autoimmune interstitial lung, joint, and kidney diseaseNcstn
autoimmune thrombocytopenic purpuraIl4
autoimmune thyroiditisIl4
autosomal dominant cerebellar ataxiaEp300
autosomal dominant intellectual developmental disorder 8Notch1
autosomal dominant nocturnal frontal lobe epilepsy 5Notch1
autosomal dominant polycystic kidney diseaseCdkn1a , Myc
autosomal dominant Robinow syndrome 1Dvl1 , Dvl3
autosomal dominant Robinow syndrome 2Dvl1 , Dvl3
autosomal dominant Robinow syndrome 3Dvl3
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 27Jag2
autosomal recessive polycystic kidney diseaseMyc
B-Cell Chronic Lymphocytic LeukemiaCbl , Fbxw7
B-lymphoblastic leukemia/lymphomaCcnd1 , Gata3 , Myc
B-lymphoblastic leukemia/lymphoma with hyperdiploidyCbl
Bardet-Biedl syndromeJag1
Barrett's esophagusCdkn1a
basal cell carcinomaFbxw7
Behcet's diseaseIl4
bicuspid aortic valve diseaseNotch1
biliary atresiaDlk1
biliary tract benign neoplasmIl4
BlisterAdam17
Bloom syndromeAdam10 , Aph1b , Dll4 , Furin , Rab11a
body dysmorphic disorderHdac2
bone diseaseJag1
Bovine TuberculosisIl4
Bowen's DiseaseCcnd1 , Cdkn1a
brain diseaseSpen
Brain HypoxiaAdam17 , Ep300
Brain InjuriesCdkn1a , Il4 , Skp2 , Snw1
Brain NeoplasmsCcnd1 , Dll1 , Dtx2 , Hes5
breast cancerDll4 , Kat2b , Kdm1a , Myc , Ncor2 , Psen2 , Skp2 , Snw1
Breast Cancer, FamilialNcor1
breast carcinomaEp300 , Hdac1 , Snw1
breast ductal carcinomaNotch3 , Spen
Breast NeoplasmsAdam10 , Ccnd1 , Cdkn1a , Dll1 , Dll4 , Dtx3 , Eno1 , Ep300 , Fbxw7 , Hes1 , Hey1 , Hey2 , Heyl , Jag1 , Jag2 , Myc , Ncor1 , Notch1 , Notch2 , Notch3 , Notch4 , Psen2
Bronchial HyperreactivityGata3
bronchiolitis obliteransIl4
bronchiolo-alveolar adenocarcinomaCcnd1
bronchitisHdac2
Brugada syndromeHey2
Brugada syndrome 5Psenen
Burkitt lymphomaMyc
BurnsCcnd1 , Dll4
CADASILNotch3
CADASIL 1Notch3
CADASIL2Notch3
CAKUTGata3 , Jag1 , Notch2
Calcification of Aortic ValveDll4 , Notch1
calcinosisNotch1
CarcinogenesisGata3
carcinomaCcnd1 , Cdkn1a , Eno1 , Furin , Gata3 , Myc
cardiac amyloidosisCrebbp
cardiac arrestEp300
CardiomegalyDll4 , Ep300 , Hdac2 , Hes1 , Myc , Notch1 , Yy1
cardiomyopathyAdam10 , Ep300 , Il4 , Psen1
Cardiovascular AbnormalitiesNotch1
Carotid Artery InjuriesCbl , Hey1 , Hey2 , Heyl , Jag1 , Myc , Notch1 , Notch2 , Notch3
carotid stenosisIl4
Carpenter Syndrome 2Dll3 , Numbl
castration-resistant prostate carcinomaKdm1a
cataractAdam10
CD3epsilon deficiencyCbl
Cecal NeoplasmsCcnd1
central precocious pubertyDlk1
cerebellar ataxiaDnm1
cerebral amyloid angiopathyPsen1
cerebral cavernous malformationNotch3
Cerebral HemorrhagePsen1
cerebral infarctionNotch3
cerebral palsyJag1
cervix uteri carcinoma in situCcnd1 , Cdkn1a , Hdac1 , Hdac2 , Skp2
Charcot-Marie-Tooth Disease Axonal Type 2HHJag1
Charcot-Marie-Tooth disease axonal type 2OJag2
Charcot-Marie-Tooth disease dominant intermediate CHeyl , Mycbp
CHARGE syndromeEp300
Chemical and Drug Induced Liver InjuryEno1 , Il4 , Notch1
cherubismCtbp1
ChloracneRab11a
cholangiocarcinomaNotch1
cholestasisIl4
cholesteatoma of middle earCdkn1a , Myc , Notch1
Choroidal NeovascularizationDll4
Choroidal Neovascularization, ExperimentalDll4
Chromosome 11, Partial Trisomy 11qCbl
chromosome 1p36 deletion syndromeDvl1 , Eno1 , Hes5 , Mfap2 , Spen
Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MBDtx2
Chromosome BreakageIl4 , Myc
Chronic Hepatitis BIl4
Chronic Hepatitis CCcnd1 , Il4
chronic lymphocytic leukemiaFbxw7 , Myc
chronic myeloid leukemiaHes1 , Ncstn
chronic obstructive pulmonary diseaseCdkn1a , Hdac2
Chronic PancreatitisDll1 , Jag1
clear cell renal cell carcinomaEp300 , Myc
cleft lipMyc
cleft palateMyc
Cleft Palate, Psychomotor Retardation, and Distinctive Facial FeaturesKdm1a
cognitive disorderHdac2 , Il4 , Psen1
Cognitive DysfunctionAdam10 , Psen1
colitisAdam17 , Il4
colon adenomaCcnd1
colon carcinomaEp300
Colonic NeoplasmsCcnd1 , Cdkn1a , Hdac2 , Hes1 , Kdm1a , Myc , Notch1
Colonic PolypsHdac2
colorectal cancerAdam10 , Aph1b , Cbl , Ccnd1 , Dll4 , Ep300 , Fbxw7 , Hdac1 , Rab11a
colorectal carcinomaEp300
Colorectal NeoplasmsCcnd1 , Crebbp , Ctbp1 , Ep300 , Fbxw7 , Myc , Neurl1
common coldIl4
common variable immunodeficiencyHes7
common variable immunodeficiency 4Ep300
Compton-North congenital myopathyCntn1
cone-rod dystrophy 6Hes7
Congenital AbnormalitiesDll3 , Notch1
Congenital CholesteatomaCdkn1a
congenital diaphragmatic herniaCbl , Ep300
congenital disorder of glycosylation IdDvl3
congenital disorder of glycosylation IjCbl
congenital heart diseaseJag1 , Maml3 , Notch1
congenital hypoplastic anemiaDll3 , Numbl
congenital myasthenic syndrome 13Cbl
congenital myasthenic syndrome 18Jag1
congenital myasthenic syndrome 8Dvl1
congestive heart failureAdam17 , Cbl , Ep300 , Yy1
connective tissue diseaseMfap5 , Notch1
contact dermatitisIl4
Corneal OpacityJag1
coronary artery diseaseAph1b , Furin
Coronary DiseaseKat2b
coronary restenosisMyc
cortical dysplasia-focal epilepsy syndromeCul1
COVID-19Cir1 , Eno1 , Gata3 , Il4 , Myc , Psen2 , Rbbp8
Craniofacial AbnormalitiesDll3 , Ep300 , Jag2 , Notch1
craniosynostosisDll3 , Hes7 , Numbl
Critical IllnessKdm1a
cryptorchidismCbl
Currarino syndromeDvl3
cutaneous leishmaniasisIl4
cystic echinococcosisIl4
cystitisIl4
D-2-hydroxyglutaric aciduria 2Furin
DeafnessJag1
Deafness, Congenital Heart Defects, and Posterior EmbryotoxonJag1
Delayed HypersensitivityGata3
dementiaNotch4
demyelinating diseaseHdac1 , Myc
depressive disorderNotch3
dermatitisIl4
dermatomyositisIl4
developmental and epileptic encephalopathyDnm1
developmental and epileptic encephalopathy 1Dnm1
developmental and epileptic encephalopathy 12Jag1
developmental and epileptic encephalopathy 14Notch1
developmental and epileptic encephalopathy 18Ep300
developmental and epileptic encephalopathy 21Mfap5
developmental and epileptic encephalopathy 31ADnm1
developmental and epileptic encephalopathy 31BDnm1
developmental delay, hypotonia, and impaired languageFbxw7
Developmental DisabilitiesCbl , Crebbp , Kdm1a , Ncor1
Developmental DiseaseDnm1 , Mark2 , Spen
diabetes mellitusDll4 , Hes1 , Hes5 , Hey1
Diabetic CardiomyopathiesNotch1
Diabetic FootNotch1
Diabetic NephropathiesCdkn1a , Ep300 , Hdac2 , Yy1
diabetic retinopathyDll4 , Ep300 , Hes1 , Hey2 , Jag1 , Kdm1a , Notch1
Diamond-Blackfan anemiaDll3 , Hes7 , Numbl
diffuse large B-cell lymphomaCrebbp , Myc , Skp2
DiGeorge syndromeDvl1
dilated cardiomyopathyPsen1 , Psen2 , Rbpj
dilated cardiomyopathy 1LLDvl1 , Hes5
dilated cardiomyopathy 1UPsen1
dilated cardiomyopathy 1VPsen2
Dilated Cardiomyopathy with Left Ventricular NoncompactionCbl
disease of cellular proliferationMyc , Skp2 , Yy1
disease of mental healthDvl1
Disease ProgressionCcnd1 , Kdm1a , Myc , Yy1
distal 10q deletion syndromeAdam12
Dog DiseasesDnm1
double outlet right ventricleDll4
Dowling-Degos diseaseAdam10 , Pofut1
Dowling-Degos Disease 2Pofut1
drug allergyIl4
Drug EruptionsIl4
Ductal CarcinomaMyc
ductal carcinoma in situCcnd1 , Cdkn1a , Notch4
DwarfismCbl , Dvl3 , Ep300 , Hes7
dyskeratosis congenitaHes7
dysostosisDll3
dystoniaPsenen
early infantile epileptic encephalopathyDnm1
EdemaIl4
Ehlers-Danlos syndrome classic type 1Notch1
Ehlers-Danlos syndrome dermatosparaxis typeMaml1
Ehlers-Danlos syndrome hypermobility typeNotch1
Ehlers-Danlos syndrome spondylodysplastic type 2Dvl1 , Hes5
Embryo LossCdkn1a
Emery-Dreifuss muscular dystrophyMfng
EmphysemaHdac2
end stage renal diseaseGata3
endometrial cancerNotch1 , Notch4
endometrial carcinomaNcor2
endometrial hyperplasiaSkp2
Endometrial NeoplasmsCcnd1 , Cdkn1a , Ep300 , Fbxw7 , Hdac1 , Hdac2 , Jag1 , Myc , Skp2
endometriosisHdac1 , Hdac2 , Ncor1 , Rbpj
EndotoxemiaEp300
EosinophiliaGata3
epilepsyCrebbp , Dnm1 , Hes1 , Mark2 , Notch1 , Notch3
esophageal atresiaNotch1
esophageal carcinomaEp300 , Fbxw7 , Myc
Esophageal NeoplasmsCcnd1 , Cdkn1a , Eno1 , Myc
esophagus squamous cell carcinomaCcnd1 , Cdkn1a , Crebbp , Ep300 , Fbxw7 , Kat2b , Notch1 , Notch2 , Notch3 , Spen
Exercise IntoleranceDnm1
Experimental ArthritisAdam10 , Adam17 , Cbl , Il4 , Jag1
Experimental Autoimmune EncephalomyelitisAdam17 , Dlk1 , Dll1 , Dll4 , Il4 , Jag1
Experimental Autoimmune UveitisDll4 , Notch1
Experimental Autoimmune UveoretinitisIl4
Experimental ColitisAdam17
Experimental Diabetes MellitusCdkn1a , Ep300 , Furin , Hdac1 , Hdac2 , Il4 , Myc
Experimental LeukemiaCbl
Experimental Liver CirrhosisAdam17 , Cdkn1a , Il4 , Myc , Ncor2
Experimental Liver NeoplasmsCcnd1 , Cdkn1a , Myc , Notch1
Experimental Mammary NeoplasmsCcnd1 , Eno1 , Furin , Gata3 , Myc , Notch4
Experimental MelanomaKdm1a
Experimental NeoplasmsCcnd1
Eye AbnormalitiesJag1
FaciesJag1
facioscapulohumeral muscular dystrophyCdkn1a
Familial Acne Inversa 1Ncstn
Familial Acne Inversa 2Psenen
Familial Acne Inversa 3Psen1
familial adenomatous polyposisHdac2
familial adenomatous polyposis 1Il4 , Skp1
Familial Amyloid PolyneuropathiesCrebbp
familial hemiplegic migraineNcstn
Familial Hidradenitis SuppurativaNcstn , Psen1 , Psenen
familial hypertrophic cardiomyopathyMib1
familial hypocalciuric hypercalcemiaDtx3l
familial melanomaDtx3
Familial Thoracic Aortic Aneurysm 9Mfap5
fetal alcohol spectrum disorderHdac2
Fetal Growth RetardationDlk1 , Hdac1 , Hdac2
FibrosisAdam10 , Il4 , Notch2
FlatfootJag1
focal epilepsyNeurl2 , Rbpjl
Focal Nodular HyperplasiaDll4 , Notch1
focal segmental glomerulosclerosis 5Jag2
Folate-Responsive Megaloblastic AnemiaNotch1
Follicular CystNotch2
follicular lymphomaCrebbp
frontotemporal dementiaPsen1
Frontotemporal Dementia and/or Amyotrophic Lateral SclerosisAdam10
frontotemporal dementia and/or amyotrophic lateral sclerosis 1Maml1
Fuchs' endothelial dystrophyCdkn1a
fundus dystrophyJag1
GABRIELE-DE VRIES SYNDROMEYy1
galactosialidosisNeurl2
gastric adenocarcinomaCrebbp , Fbxw7
Gastro-Enteropancreatic Neuroendocrine TumorGata3 , Notch2
gastrointestinal stromal tumorAph1a , Ncstn , Psen2
Gaucher's diseaseIl4
genetic diseaseAdam10 , Adam12 , Adam17 , Aph1a , Aph1b , Cbl , Ccnd1 , Cdkn1a , Cir1 , Cntn1 , Cntn6 , Crebbp , Ctbp1 , Ctbp2 , Cul1 , Dlk1 , Dll1 , Dll3 , Dll4 , Dner , Dnm1 , Dtx1 , Dtx2 , Dtx3 , Dtx3l , Dtx4 , Dvl1 , Dvl3 , Eno1 , Ep300 , Eps15 , Fbxw7 , Furin , Gata3 , Hdac1 , Hdac2 , Hes1 , Hes5 , Hes7 , Hey1 , Hey2 , Heyl , Il4 , Itch , Jag1 , Jag2 , Kat2a , Kat2b , Kdm1a , Lfng , Lnx1 , Maml1 , Maml2 , Maml3 , Mark2 , Mfap2 , Mfap5 , Mfng , Mib1 , Myc , Mycbp , Ncor1 , Ncor2 , Ncstn , Neurl1 , Neurl2 , Notch1 , Notch2 , Notch3 , Notch4 , Numb , Numbl , Pofut1 , Psen1 , Psen2 , Psenen , Ptcra , Rab11a , Rbbp8 , Rbpj , Rbpjl , Rfng , Skp1 , Skp2 , Snw1 , Spen , Yy1
Genomic InstabilityCcnd1 , Fbxw7
glaucomaCrebbp , Hdac1
glioblastomaCrebbp , Fbxw7 , Hes1 , Hey1 , Jag1 , Jag2 , Myc , Ncor1 , Notch1 , Notch2 , Notch3
GliosisPsen1
glomerulonephritisEp300
Goldberg-Shprintzen syndromeDvl1 , Hes5
GranulomaIl4
Graves' diseaseIl4
Growth DisordersCbl
growth hormone secreting pituitary adenomaCdkn1a
Habitual AbortionsCdkn1a
Hajdu-Cheney syndromeNotch2
HallucinationsPsen1
Hand OsteoarthritisIl4
head and neck squamous cell carcinomaCcnd1 , Crebbp , Ep300 , Fbxw7 , Lnx1
Hearing LossGata3
Hearing Loss, Noise-InducedCdkn1a , Cntn1
heart diseaseEp300 , Hdac1
heart valve diseaseNotch1
hemangioblastomaDll4 , Hey1 , Notch4
hemangiomaNotch1
hemangiopericytomaDll4 , Hes1 , Hey1 , Hey2 , Notch1 , Notch4
hematologic cancerCbl
Hematologic NeoplasmsCbl
Hemorrhagic ShockIl4 , Myc
hepatitis BIl4 , Kat2a
hepatitis CIl4 , Myc
hepatoblastomaEp300
hepatocellular carcinomaCbl , Ccnd1 , Cdkn1a , Crebbp , Dlk1 , Eno1 , Ep300 , Hdac2 , Jag1 , Kat2b , Kdm1a , Myc , Notch3 , Skp2 , Snw1
hereditary breast ovarian cancer syndromeEp300 , Notch2
Hereditary Hemorrhagic Telangiectasia, Type 1Psen1
Hereditary Neoplastic SyndromesIl4 , Skp1
hereditary spastic paraplegia 75Psenen
herpes zosterIl4
high grade gliomaCcnd1 , Cdkn1a , Dlk1 , Dll4 , Fbxw7 , Il4 , Mark2
Hirschsprung Disease 1Crebbp , Notch2
Hirschsprung's diseaseCrebbp , Notch2 , Notch4
Hittner Hirsch Kreh SyndromeEp300
HIV SeropositivityAph1b
Hodgkin's lymphomaGata3 , Myc
holoprosencephalyDll1
human immunodeficiency virus infectious diseaseCdkn1a , Yy1
Human InfluenzaIl4
Huntington's diseaseCrebbp , Ep300 , Hdac1 , Ncor1
Huntington's Disease-Like SyndromePsen2
HyperalgesiaEp300
hyperglycemiaCbl
HyperoxiaCdkn1a
hyperparathyroidismCcnd1 , Myc
Hyperphosphatemic Familial Tumoral Calcinosis 1Mfap5
HyperplasiaCcnd1 , Cdkn1a , Kdm1a
hypertensionEno1 , Ep300
hypertrophic cardiomyopathyAph1b , Hey2 , Myc , Yy1
HypertrophyCdkn1a
hypoparathyroidismGata3
hypoparathyroidism-deafness-renal disease syndromeGata3
hypophosphatemiaHes7
hypoplastic left heart syndromeNotch1
hypothyroidismIl4 , Ncor1
HYPOTONIA, ATAXIA, DEVELOPMENTAL DELAY, AND TOOTH ENAMEL DEFECT SYNDROMECtbp1
HypovolemiaCdkn1a
idiopathic generalized epilepsyCrebbp , Dnm1 , Dvl1
idiopathic pulmonary fibrosisEp300
IgA glomerulonephritisAdam10 , Notch2
Immediate HypersensitivityIl4
immunodeficiency 16Dvl1 , Hes5
immunodeficiency 17Cbl
immunodeficiency 18Cbl
immunodeficiency 19Cbl
immunodeficiency 38Dvl1 , Hes5
immunodeficiency 42Aph1a
immunodeficiency-centromeric instability-facial anomalies syndrome 1Pofut1
impotenceCcnd1
infantile myofibromatosisNotch3
Infantile Myofibromatosis 1Notch3
Infantile Myofibromatosis 2Notch3
infantile Refsum diseasePtcra
InfarctionNotch3
InflammationGata3
inflammatory bowel disease 28Cbl
intellectual disabilityCcnd1 , Crebbp , Ctbp1 , Dtx4 , Ep300 , Hes7 , Kdm1a , Maml2 , Mark2 , Mib1 , Numb , Psen1 , Rab11a , Rbbp8 , Yy1
Intestinal NeoplasmsCdkn1a
Intestinal PolypsCcnd1
Intracranial HemorrhagesPsen1
invasive ductal carcinomaNotch3 , Spen
invasive lobular carcinomaCcnd1
inverted papillomaCdkn1a
irritant dermatitisIl4
ischemiaDll4
isolated microphthalmia 5Cbl
Joubert syndrome 1Notch1
Joubert syndrome 25Dvl1 , Hes5
juvenile myelomonocytic leukemiaCbl
juvenile rheumatoid arthritisMaml2
Kagami-Ogata syndromeDlk1
Kawasaki diseaseIl4
keratoacanthomaNotch1 , Notch2
Keratoconus 1Skp1
kidney diseaseCdkn1a
kidney failureAdam10 , Notch2
Kidney NeoplasmsCcnd1
Kidney Reperfusion InjuryAdam17 , Ep300 , Myc
Kleefstra syndrome 1Notch1
Klippel-Feil syndrome 3Mfap5
Knee OsteoarthritisIl4
Kohlschutter-Tonz syndromeCrebbp
laryngeal squamous cell carcinomaCdkn1a
lateral meningocele syndromeNotch3
learning disabilityPsen1
Left Ventricular HypertrophyAdam17 , Myc
Left Ventricular Noncompaction 7Mib1
Leigh diseaseNotch1
leiomyomaMyc
leishmaniasisIl4
leukemiaCcnd1
leukocyte adhesion deficiency 3Dtx4 , Mark2
LEUKODYSTROPHY AND ACQUIRED MICROCEPHALY WITH OR WITHOUT DYSTONIADll3
Li-Fraumeni syndromeHes7
limb ischemiaDll4
Lip NeoplasmsCdkn1a
lipoid nephrosisCdkn1a
liver benign neoplasmCdkn1a
liver cancerCcnd1 , Jag1
liver cirrhosisHdac2 , Myc
Liver InjuryMyc
Liver MetastasisFbxw7
Liver NeoplasmsCcnd1 , Cdkn1a , Myc , Ncor1
localized sclerodermaCdkn1a
long QT syndromeItch
long QT syndrome 10Cbl
lung adenocarcinomaCcnd1 , Crebbp , Dll4 , Eno1 , Ep300 , Fbxw7 , Myc , Notch1
lung cancerDvl3 , Myc
lung large cell carcinomaDll4 , Notch1
Lung NeoplasmsCcnd1 , Cdkn1a , Hes1 , Hey1 , Jag1 , Myc , Notch2 , Notch3
lung non-small cell carcinomaCbl , Ccnd1 , Cdkn1a , Eno1 , Hes1 , Kat2a , Kdm1a , Myc , Notch1 , Notch3
Lung Reperfusion InjuryCrebbp , Il4 , Myc
lung small cell carcinomaCcnd1 , Crebbp , Dll4 , Ep300 , Myc , Notch1 , Skp2
lung squamous cell carcinomaCcnd1 , Crebbp , Ep300 , Fbxw7
lymphangioleiomyomatosisHes1 , Jag2
Lymphatic MetastasisCbl , Cdkn1a , Skp2
lymphomaNotch1
lymphopeniaCbl
lymphoproliferative syndrome 2Mfap5
macular degenerationCdkn1a
male infertilityCbl , Eno1
malignant astrocytomaCcnd1 , Dll3 , Hey1 , Hey2 , Notch1 , Notch2
malignant mesotheliomaCdkn1a , Il4
malignant ovarian germ cell neoplasmCbl
mantle cell lymphomaCcnd1
maple syrup urine diseaseDll3 , Numbl
Marfan syndromeNotch1
Marfanoid Hypermobility SyndromeNotch1
Marfanoid Mental Retardation Syndrome, AutosomalCrebbp
maturity-onset diabetes of the young type 1Dll3 , Rbpj , Rbpjl
maxillary sinus squamous cell carcinomaCdkn1a
medulloblastomaCcnd1 , Crebbp , Ep300 , Fbxw7 , Myc , Skp2
melanomaCdkn1a , Crebbp , Ep300 , Fbxw7 , Hdac2 , Kdm1a
membranoproliferative glomerulonephritisEp300
Memory DisordersHdac2 , Psen1
meningiomaHes1
Meningococcal InfectionsIl4
Menke-Hennekam SyndromeCrebbp
Menke-Hennekam Syndrome 1Crebbp
Menke-Hennekam Syndrome 2Ep300
Merkel cell carcinomaMyc
metabolic dysfunction-associated steatotic liver diseaseIl4
MetaplasiaGata3
MHC class II deficiencyAph1a
microcephalyCbl , Ctbp1 , Ep300 , Hes7 , Rab11a , Rbbp8
Microcephaly with Mental Retardation and Digital AnomaliesRbbp8
microphthalmiaNotch1
Microsatellite InstabilityHdac2
middle cerebral artery infarctionHdac2 , Il4
migraineNotch3
migraine with auraNotch3
migraine without auraNotch3
mitochondrial complex III deficiency nuclear type 1Ncor1
mitochondrial complex III deficiency nuclear type 2Ncor1
mitral valve insufficiencyHes7
Monoclonal B-Cell LymphocytosisNotch2
Mouth NeoplasmsEno1
Multicystic Dysplastic KidneyEp300
Multiple AbnormalitiesEp300
multiple myelomaCbl , Ccnd1 , Crebbp , Ncor2 , Notch2 , Rbbp8 , Yy1
multiple sclerosisHdac1 , Il4 , Jag1 , Notch4 , Rbpj
Multisystem Autoimmune Disease with Facial DysmorphismItch
myelodysplastic syndromeCrebbp , Dlk1 , Hdac1 , Myc
myelofibrosisNcor2
myeloid leukemiaHdac2
myeloid neoplasmCbl
myeloproliferative neoplasmNotch1
myocardial infarctionDvl1
Myocardial IschemiaCcnd1 , Dll4 , Notch1
Myocardial Reperfusion InjuryCbl , Crebbp
myoclonic dystonia 26Mfng
myoclonic-atonic epilepsyDnm1
myoepitheliomaSpen
Nasopharyngeal NeoplasmsCcnd1
nasopharynx carcinomaSpen
nemaline myopathy 6Aph1b , Rab11a
Nematode InfectionsIl4
NeointimaYy1
Neonatal HyperbilirubinemiaNcor1
Neonatal Inflammatory Skin and Bowel Disease 1Adam17
Neoplasm InvasivenessCtbp2 , Eno1 , Kdm1a , Notch2
Neoplasm MetastasisCcnd1 , Cdkn1a , Myc
Neoplastic Cell TransformationCcnd1 , Ctbp2 , Myc , Notch1
nephritisIl4
nephroblastomaMyc
nephronophthisis-like nephropathy 1Ep300
nephrosisGata3
nephrotic syndromeIl4
Nerve DegenerationPsen1
nervous system diseaseHes5 , Notch1
Nervous System Lead PoisoningEp300
Nervous System MalformationsCrebbp , Psen1
neural tube defectKat2a
neuroblastomaGata3 , Myc
neurodegeneration with brain iron accumulation 2AMfng
neurodegenerative diseasePsen1
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIESCrebbp
NEURODEVELOPMENTAL DISORDER WITH NONSPECIFIC BRAIN ABNORMALITIES AND WITH OR WITHOUT SEIZURESDll1
Neurodevelopmental DisordersCbl , Cntn6 , Crebbp , Dnm1 , Dvl1 , Eno1 , Ep300 , Fbxw7 , Gata3 , Hes5 , Il4 , Skp1 , Skp2 , Yy1
neuroectodermal tumorMyc
neuronal ceroid lipofuscinosisRab11a
Niemann-Pick disease type C1Mib1 , Rbbp8
non-Hodgkin lymphomaCcnd1 , Myc
Noonan Like SyndromeCbl
Noonan syndromeCbl
Noonan syndrome 1Cbl
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaCbl
obesityEp300 , Myc
ocular hypertensionCdkn1a
oligodendrogliomaDtx1 , Hes1 , Hey1
Optic Nerve InjuriesEp300 , Snw1
Oral Lichen PlanusCdkn1a
oral mucosa leukoplakiaCdkn1a
oral squamous cell carcinomaCdkn1a , Hes1 , Notch1 , Skp2
osteoarthritisAdam12 , Eno1 , Jag1 , Ncor2
osteochondrodysplasiaDll3 , Hes7
osteoporosisEno1 , Myc
osteosarcomaCbl , Myc
Otitis Media with EffusionIl4
ovarian carcinomaCcnd1
ovarian cystMfap2
ovarian germ cell cancerCbl
Ovarian NeoplasmsCdkn1a , Hdac1 , Hdac2 , Myc , Skp2
ovarian serous cystadenocarcinomaFbxw7
Oxygen-Induced RetinopathyDll4
Painful NeuropathyEp300
pancreatic adenocarcinomaCcnd1
pancreatic cancerCcnd1 , Il4 , Myc , Notch1 , Snw1
pancreatic carcinomaCdkn1a , Rbbp8
pancreatic ductal adenocarcinomaCcnd1
pancreatic ductal carcinomaCcnd1 , Cdkn1a , Dtx1 , Dtx4 , Hdac1 , Hes1 , Hey1 , Hey2 , Il4 , Jag1 , Jag2 , Notch1 , Notch3 , Notch4
Pancreatic Intraepithelial NeoplasiaCcnd1 , Hdac1
pancreatic solid pseudopapillary carcinomaCcnd1
papillary renal cell carcinomaFbxw7
papillomaCcnd1 , Cdkn1a
paraplegiaDtx3
parathyroid carcinomaAph1a , Ncstn , Psen2
Paroxysmal Atrial FibrillationMib1
pelvic inflammatory diseaseIl4
penile benign neoplasmCcnd1
Perennial Allergic RhinitisIl4
perinatal necrotizing enterocolitisEno1
Peripheral Nerve InjuriesCbl
Peritoneal DiseasesNotch1
peroxisome biogenesis disorder 12ANcstn
peroxisome biogenesis disorder 2BMfap5
Peroxisome Biogenesis Disorder, Complementation Group 7Dvl1 , Hes5
pervasive developmental disorderFbxw7
Peyronie's diseaseHdac2
PHGDH deficiencyNotch2
Phyllodes TumorCdkn1a
Pick's diseasePsen1
Pituitary NeoplasmsCdkn1a
Plaque, AtheroscleroticDll4
pleomorphic xanthoastrocytomaDtx2
pleural diseaseIl4
pleuropulmonary blastomaYy1
Pneumococcal MeningitisAdam17
pneumoconiosisIl4
pneumoniaIl4
polycystic kidney diseaseDll4 , Myc
polycystic kidney disease 1Myc
polycystic ovary syndromeNcor1 , Ptcra
polymyositisIl4
pre-eclampsiaCrebbp , Notch2
pre-malignant neoplasmCcnd1 , Cdkn1a
Premature AgingCdkn1a
Premature BirthIl4
Prenatal Exposure Delayed EffectsAdam10 , Notch2
Presenile and Senile DementiaPsen2
primary biliary cholangitisCdkn1a , Il4
primary coenzyme Q10 deficiency 7Dnm1 , Notch1
primary cutaneous T-cell non-Hodgkin lymphomaIl4
Primary Lymphedema with MyelodysplasiaDtx3l
primary microcephalyRab11a
primary open angle glaucomaCdkn1a
primary ovarian insufficiencyMyc , Notch2
primary pulmonary hypertensionHdac1
Primary Pulmonary Hypertension, 1Notch1 , Notch3
Primitive Neuroectodermal TumorsHes1 , Hey1 , Notch2
prion diseaseNotch1
Progressive Psychomotor DeteriorationNotch3
prolactinomaMyc
prostate adenocarcinomaMyc
prostate cancerCcnd1 , Cdkn1a , Dll1 , Ep300 , Maml1 , Myc , Notch3 , Skp2
prostate carcinomaHdac2 , Skp2
prostate carcinoma in situCcnd1 , Hdac1 , Myc
prostatic hypertrophyMyc
Prostatic NeoplasmsCcnd1 , Cdkn1a , Crebbp , Ctbp2 , Hdac1 , Myc , Ncor1 , Ncor2 , Spen
proteasome-associated autoinflammatory syndrome 1Cdkn1a , Notch4
psoriasisCdkn1a , Il4
Pulmonary Arterial HypertensionNotch1 , Notch3
Pulmonary AtresiaCtbp2
pulmonary emphysemaHdac2
pulmonary fibrosisIl4 , Jag1 , Notch1 , Psen2
Pulmonary HemorrhagePsen2
pulmonary hypertensionCdkn1a , Dll4 , Hdac1 , Hdac2 , Hey1 , Il4 , Myc , Notch1
pulmonary tuberculosisIl4
RADIO-TARTAGLIA SYNDROMESpen
Rafiq syndromeNotch1
RASopathyCbl
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsCcnd1
renal cell carcinomaCcnd1 , Dll4 , Myc , Skp2
renal fibrosisAdam17 , Myc
renal hypertensionCdkn1a
Reperfusion InjuryCcnd1 , Cdkn1a , Ep300
respiratory allergyIl4
Respiratory SoundsIl4
Respiratory Tract InfectionsIl4
reticulate acropigmentation of KitamuraAdam10
Retina Reperfusion InjuryHdac2
retinal degenerationCdkn1a
RETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIESCdkn1a
retinopathy of prematurityDll4 , Notch1
rhabdoid cancerMyc
rhabdomyosarcomaCbl
rheumatoid arthritisEno1 , Gata3 , Hdac1 , Kat2b , Notch4 , Rbpj
rhinitisIl4
RhinosinusitisIl4
Right Ventricular HypertrophyHdac1
Rigidity and Multifocal Seizure Syndrome, Lethal NeonatalLfng
Robinow syndromeDvl1 , Dvl3
Rubinstein-Taybi syndromeCrebbp , Ep300
Salivary Gland NeoplasmsCcnd1 , Cdkn1a , Jag1 , Mark2
sarcoidosisCdkn1a
sarcomaMaml3
SarcopeniaCdkn1a
schizophreniaCbl , Cntn6 , Hes1 , Kdm1a , Ncstn , Notch4 , Rbpj
sciatic neuropathySnw1
scoliosisCrebbp , Dll3 , Hes7 , Jag1 , Notch1
Seasonal Allergic RhinitisIl4
sebaceous gland neoplasmCdkn1a
Seckel syndromeRbbp8
Seckel syndrome 2Rbbp8
sensorineural hearing lossGata3
SepsisCdkn1a , Ep300 , Gata3 , Il4
serous cystadenocarcinomaCdkn1a
severe congenital neutropenia 3Aph1a
severe congenital neutropenia 5Aph1a
Sezary's diseaseCrebbp
SHONE COMPLEXNotch1
short-rib thoracic dysplasia 9 with or without polydactylyCrebbp
Shprintzen-Goldberg CraniosynostosisDvl1 , Hes5
Silver-Russell Syndrome 1Dlk1
sinonasal undifferentiated carcinomaMaml3
Sjogren's syndromeIl4
skin melanomaCrebbp , Fbxw7 , Myc
Skin NeoplasmsCdkn1a , Notch1 , Notch2 , Notch3 , Notch4
Sotos syndromeMaml1
Spinal Cord InjuriesIl4
Spine OsteoarthritisSkp2
Spinocerebellar AtaxiasEp300 , Kat2a
SplenomegalyNotch1 , Psen1
split hand-foot malformation 5Cir1
spondylocostal dysostosisDll3 , Hes7
spondylocostal dysostosis 1Dll3
spondylocostal dysostosis 2Hes7 , Lfng
spondylocostal dysostosis 3Lfng
spondylocostal dysostosis 4Hes7
Spondylocostal Dysostosis, Autosomal RecessiveDll3 , Hes7 , Lfng
Sporadic Papillary Renal Cell CarcinomaFbxw7 , Myc
Sprengel DeformityHes7
squamous cell carcinomaCcnd1 , Cdkn1a , Crebbp , Eno1 , Ep300 , Hdac1 , Hdac2 , Myc , Notch1 , Notch2 , Notch3 , Notch4
Staphylococcal InfectionsIl4
status epilepticusAdam10 , Ccnd1
steatotic liver diseaseMyc
Stevens-Johnson syndromeCul1 , Ep300
stomach cancerHdac2
stomach carcinomaCdkn1a
Stomach NeoplasmsCcnd1 , Cdkn1a , Eno1 , Myc , Notch2
StrokeCbl , Hdac1 , Hdac2 , Il4 , Jag1 , Notch3
Surgical WoundDll4 , Notch1
syndactylyDll3 , Jag2
syndromic microphthalmia 5Adam17 , Notch1 , Notch4
systemic lupus erythematosusCdkn1a , Ep300 , Il4
systemic sclerodermaIl4 , Notch4
T-cell acute lymphoblastic leukemiaFbxw7 , Notch1
T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac MalformationsNeurl2 , Rbpjl
T-cell non-Hodgkin lymphomaCdkn1a , Ep300 , Kdm1a
tauopathyHdac1
temporal arteritisDll1 , Il4 , Jag1
temporal lobe epilepsyHdac2
Temporomandibular Joint OsteoarthritisDll4
Temtamy syndromeMfap5
teratomaCrebbp
tetralogy of FallotHey2 , Jag1 , Notch1
thoracic aortic aneurysmAdam10 , Adam17 , Mfap5 , Notch1
Thumb DeformityCrebbp , Ep300
thyroid cancerMyc
thyroid gland papillary carcinomaCcnd1 , Myc
Thyroid NeoplasmsCcnd1 , Cdkn1a
Tongue NeoplasmsCdkn1a
tongue squamous cell carcinomaCcnd1 , Cdkn1a
toxocariasisIl4
transient cerebral ischemiaCbl , Dll4 , Ep300 , Kdm1a , Notch1
transitional cell carcinomaCcnd1 , Cdkn1a , Crebbp , Ep300 , Fbxw7 , Ncor1 , Skp2
Transplant RejectionMyc
transthyretin amyloidosisCrebbp
traumatic brain injuryAdam10 , Ncstn , Psen1
trichorhinophalangeal syndrome type IMyc
trypanosomiasisIl4
tuberous sclerosis 1Notch1
type 1 diabetes mellitusCbl , Hdac1 , Hdac2 , Il4 , Notch4 , Yy1
type 2 diabetes mellitusAdam17 , Dll3 , Ep300 , Hdac1 , Hdac2 , Notch2 , Rbpj , Rbpjl
ulcerative colitisCdkn1a
ureteral obstructionAdam10 , Adam12 , Adam17 , Hes1 , Hey1 , Hey2
urinary bladder cancerCcnd1 , Cdkn1a , Crebbp , Ep300 , Myc , Ncor1 , Ncstn
Urologic NeoplasmsCcnd1
uterine cancerFbxw7
uterine carcinosarcomaFbxw7
Uterine Cervical NeoplasmsCcnd1 , Cdkn1a , Crebbp , Ep300 , Fbxw7 , Hdac1 , Hdac2 , Hes1 , Myc , Notch1 , Notch2 , Skp2 , Yy1
VACTERL associationNotch2
varicose veinsDll4 , Hey2
vascular dementiaNotch3 , Psen2
Vascular MalformationsDll4 , Notch1
Vascular NeoplasmsDll4
vasculitisCbl
very long chain acyl-CoA dehydrogenase deficiencyHes7
visual epilepsyCcnd1 , Hdac2 , Neurl1
vitiligoIl4
von Hippel-Lindau diseaseCcnd1
Weaver syndromeCul1
Weight GainRfng
Weight LossIl4
West syndromeDnm1
Wittwer SyndromeCtbp1
Wolf-Hirschhorn syndromeCtbp1
XerostomiaIl4
Zellweger syndromePtcra
Pathway Annotations Associated with Genes in the Notch signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayCcnd1 , Myc
Alagille syndrome pathwayJag1
aldosterone signaling pathwayCrebbp , Ncor1 , Ncor2
allograft rejection pathwayIl4
altered androgen signaling pathwayNcor2
altered Notch signaling pathwayDll1 , Dll3 , Hey1 , Jag1 , Jag2 , Notch1 , Notch4 , Numb , Pofut1
altered Notch signaling pathway involving promotersHey1
altered Notch signaling pathway involving the macromolecules modifying the main playersNumb , Pofut1 , Psen2
altered Notch signaling pathway involving the main playersDll3 , Jag1 , Notch1 , Notch3
Alzheimer's disease pathwayAdam10 , Adam17 , Aph1a , Aph1b , Ncstn , Psen1 , Psen2 , Psenen
androgen signaling pathwayCrebbp , Ep300 , Ncor1 , Ncor2
asthma pathwayIl4
ataxia telangiectasia-mutated (ATM) signaling pathwayRbbp8
autoimmune thyroiditis pathwayIl4
autophagy pathwayRab11a
basal cell carcinoma pathwayDvl1 , Dvl3
CADASIL pathwayNotch3
cell cycle pathway, mitoticCcnd1 , Cdkn1a , Crebbp , Cul1 , Ep300 , Hdac1 , Hdac1l , Hdac2 , Myc , Skp1 , Skp2
ceramide signaling pathwayCcnd1 , Myc
CHD family mediated chromatin remodeling pathwayHdac1 , Hdac2
chronic myeloid leukemia pathwayCbl , Ccnd1 , Cdkn1a , Ctbp1 , Ctbp2 , Hdac1 , Hdac1l , Hdac2 , Myc
clathrin-dependent synaptic vesicle endocytosisDnm1 , Eps15
colorectal cancer pathwayCcnd1 , Myc
cortisol signaling pathwayCrebbp , Ep300 , Kat2b , Ncor1 , Ncor2
cytokine mediated signaling pathwayIl4
E-cadherin signaling pathwayCcnd1
eicosanoid signaling pathwayDnm1 , Rab11a
endocytosis pathwayCbl , Dnm1 , Eps15 , Itch , Rab11a
endometrial cancer pathwayCcnd1 , Myc
Endoplasmic Reticulum-associated degradation pathwayCul1 , Skp1
ephrin - ephrin receptor bidirectional signaling axisCbl , Dnm1
epidermal growth factor/neuregulin signaling pathwayAdam10 , Adam12 , Adam17 , Cbl , Cdkn1a , Myc
erythropoietin signaling pathwayCbl
estrogen signaling pathwayCrebbp , Ep300 , Ncor1 , Ncor2
Fanconi syndrome pathwayEno1
Fc epsilon receptor mediated signaling pathwayIl4
Fc gamma receptor mediated signaling pathwayDnm1
fibroblast growth factor signaling pathwayCbl
forkhead class A signaling pathwayCrebbp , Dlk1 , Ep300
fructose-1,6-bisphosphatase deficiency pathwayEno1
G1 phase pathwayCcnd1
G1/S transition pathwayCcnd1 , Cdkn1a
glioma pathwayCcnd1 , Cdkn1a
gluconeogenesis pathwayEno1
glycogen storage disease type Ia pathwayEno1
glycogen storage disease type Ib pathwayEno1
glycogen storage disease type VII pathwayEno1
glycolysis pathwayEno1
glycolysis/gluconeogenesis pathwayEno1
glypican signaling pathwayFurin
Hedgehog signaling pathwayCrebbp , Hdac1 , Hdac2 , Sspo
hepatitis C pathwayCdkn1a
histone modification pathwayCrebbp , Ep300 , Hdac1 , Hdac2 , Kat2a , Kat2b , Kdm1a
homologous recombination pathway of double-strand break repairRbbp8
Huntington's disease pathwayCrebbp , Ep300 , Hdac1 , Hdac1l , Hdac2
hypoxia inducible factor pathwayCrebbp , Eno1 , Ep300 , Furin
influenza A pathwayCrebbp , Ep300 , Furin
INO80 family mediated chromatin remodeling pathwayYy1
insulin responsive facilitative sugar transporter mediated glucose transport pathwayCbl , Rab11a
insulin signaling pathwayCbl
interleukin-12 signaling pathwayIl4
interleukin-2 signaling pathwayMyc
interleukin-27 signaling pathwayGata3
interleukin-3 signaling pathwayHdac1
interleukin-4 signaling pathwayCbl , Il4
interleukin-6 signaling pathwayAdam10 , Adam17 , Myc
Jak-Stat signaling pathwayCbl , Ccnd1 , Crebbp , Ep300 , Il4 , Myc
Leishmaniasis pathwayIl4
long term potentiationCrebbp , Ep300
maturity-onset diabetes of the young pathwayHes1
measles pathwayCcnd1 , Il4
melanoma pathwayCcnd1 , Cdkn1a
mitogen activated protein kinase signaling pathwayMyc
mTOR signaling pathwaySspo , Yy1
myocarditis pathwayCcnd1
neddylation pathwayCul1
neurotrophic factor signaling pathwayPsen1 , Psen2
non-homologous end joining pathway of double-strand break repairRbbp8
non-small cell lung carcinoma pathwayCcnd1
Notch signaling pathwayAdam10 , Adam12 , Adam17 , Aph1a , Aph1b , Cbl , Ccnd1 , Cdkn1a , Cir1 , Cntn1 , Cntn6 , Crebbp , Ctbp1 , Ctbp2 , Cul1 , Dlk1 , Dll1 , Dll3 , Dll4 , Dner , Dnm1 , Dtx1 , Dtx2 , Dtx3 , Dtx3l , Dtx4 , Dvl1 , Dvl3 , Eno1 , Ep300 , Eps15 , Fbxw7 , Furin , Gata3 , Hdac1 , Hdac1l , Hdac2 , Hes1 , Hes5 , Hes7 , Hey1 , Hey2 , Heyl , Il4 , Itch , Jag1 , Jag2 , Kat2a , Kat2b , Kdm1a , Lfng , Lnx1 , Maml1 , Maml2 , Maml3 , Mark2 , Mfap2 , Mfap5 , Mfng , Mib1 , Myc , Mycbp , Ncor1 , Ncor2 , Ncstn , Neurl1 , Neurl2 , Notch1 , Notch2 , Notch3 , Notch4 , Numb , Numbl , Pofut1 , Psen1 , Psen2 , Psenen , Ptcra , Rab11a , Rbbp8 , Rbpj , Rbpjl , Rbpjl2 , Rfng , Skp1 , Skp2 , Snw1 , Spen , Sspo , Yy1
nuclear factor kappa B signaling pathwayCul1 , Skp1 , Sspo
nuclear factor, erythroid 2 like 2 signaling pathwayCdkn1a , Crebbp , Cul1 , Skp1
O-linked glycan biosynthetic pathwayLfng , Mfng , Pofut1 , Rfng
p38 MAPK signaling pathwayDlk1
p53 signaling pathwayCcnd1 , Cdkn1a , Crebbp , Ep300 , Hdac1 , Kat2a , Kat2b , Skp2 , Yy1
pancreatic cancer pathwayCcnd1
phosphatidylinositol 3-kinase-Akt signaling pathwayCdkn1a
phosphoenolpyruvate carboxykinase deficiency pathwayEno1
platelet-derived growth factor signaling pathwayCbl , Myc
prion disease pathwayNotch1
prostate cancer pathwayCcnd1 , Cdkn1a , Crebbp , Ep300 , Ncor2
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul1
Rab family mediated signaling pathwayRab11a
Reelin signaling pathwayCbl
renal cell carcinoma pathwayCrebbp , Ep300
retinoic acid signaling pathwayNcor1 , Ncor2
Rho/Rac/Cdc42 mediated signaling pathwayCbl
RNA degradation pathwayEno1
RNA polymerase I transcription pathwayCrebbp
RNA polymerase II transcription initiation pathwayKat2a , Kat2b
S phase pathwayCcnd1
scatter factor/hepatocyte growth factor signaling pathwayCbl
small cell lung carcinoma pathwayCcnd1 , Myc , Skp2
spliceosome pathwaySnw1
syndecan signaling pathwayAdam12 , Aph1a , Aph1b , Ncstn , Psen1 , Psenen
T cell receptor signaling pathwayCbl , Il4
tamoxifen pharmacodynamics pathwayNcor1 , Ncor2
thyroid cancer pathwayCcnd1 , Myc
transforming growth factor-beta Smad dependent signaling pathwayCrebbp , Itch
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Cul1 , Ep300 , Myc , Skp1
triosephosphate isomerase deficiency pathwayEno1
tuberculosis pathwayCrebbp , Ep300
tumor necrosis factor mediated signaling pathwayAdam17 , Itch
type II interferon signaling pathwayCbl , Crebbp , Ep300
ubiquitin/proteasome degradation pathwayCbl , Cul1 , Itch , Skp1 , Skp2
urinary bladder cancer pathwayCcnd1 , Cdkn1a , Myc
vascular endothelial growth factor signaling pathwayCbl
vasopressin signaling pathwayRab11a
vasopressin signaling pathway via receptor type 2Rab11a
vinblastine pharmacodynamics pathwayCdkn1a
vincristine pharmacodynamics pathwayCdkn1a
vindesine pharmacodynamics pathwayCdkn1a
vinorelbine pharmacodynamics pathwayCdkn1a
Wnt signaling pathwayCcnd1 , Crebbp , Ctbp1 , Ctbp2 , Cul1 , Dvl1 , Dvl3 , Ep300 , Myc , Psen1 , Skp1
Wnt signaling, canonical pathwayCrebbp , Dvl1 , Dvl3
Wnt signaling, non-canonical pathwayDvl1 , Dvl3
Wnt signaling, the planar cell polarity pathwayDvl1
Phenotype Annotations Associated with Genes in the Notch signaling pathway

References Associated with the Notch signaling pathway:

Ontology Path Diagram:
paths to the root
paths to the root

Import into Pathway Studio: