WNT SIGNALING, CANONICAL PATHWAY (PW:0000201)

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Description

Wnt signaling pathways initiated by the Wnt family of secreted glycoproteins play important roles in the control of embryonic development, tissue regeneration, cell polarity, proliferation and cell fate determination. The canonical, beta-catenin-dependent pathway is the best understood system. In the Wnt-producing cells, Wnts are lipid modified by Porcn; the modification is important for Wnt secretion and signaling. Transport and secretion of Wnts requires the conserved transmembrane protein Wls

Pathway Diagram:

Elsevier Inc. Wls Csnk1g1 Wnt_ligands_secreted Sostdc1 Ndp Sost Crebbp translocated Ctnnb1 palmitate Wnt_ligands Rnf43 ---| Fzd_receptors Rnf43 ---| Fzd_receptors Znrf3 ---| Fzd_receptors Znrf3 ---| Fzd_receptors sFRPs ---| Wnt_ligands_secreted Wif1 ---| Wnt_ligands_secreted Znrf3 ---| Lrp6 Csnk1g1 --+> Lrp6 Gsk3b --+> Lrp6 Btrc ---| Ctnnb1 RSPOs ---> Wnt signal potentiation Ndp ---> Wnt signal potentiation Gsk3b Lrp6 Kremen2 Kremen1 Wif1 Porcn Lef1 Smarca4 Csnk1a1 Rnf43 Znrf3 Lgr4 Lgr5 RSPOs Btrc Axin1 Dvls Wnt signal potentiation Dkk members Axin1 ---- Lrp6 Dvls ---- Fzd_receptors Lrp5 sFRPs sFRPs ---- Wnt_ligands_secreted sFRPs ---> Fzd_receptors Fzd_receptors Fzd_receptors ---- sFRPs Apc Apc ---- Axin1 Axin1 ---- Gsk3b Apc ---- Ctnnb1 Lgr4 ---- Ndp RSPOs ---> Znrf3 Lrp6 ---- Sost Lrp5 ---- Sost Lrp6 ---- Sostdc1 Dkk members ---- Lrp5 Dkk members ---> Lrp5 Dkk members ---> Lrp6 Dkk members ---- Lrp6 Lrp5 ---- Ndp Lgr4 ---- RSPOs Lgr5 ---- RSPOs Fzd_receptors ---- Wnt_ligands_secreted Lrp5 ---- Wnt_ligands_secreted Wnt target genes Kremen2 ---> Dkk members Kremen1 ---> Dkk members Dkk members ---- Kremen1 Dkk members ---- Kremen2 Lrp6 ---- Wnt_ligands_secreted Axin1 ---- Ctnnb1 Csnk1a1 ---| Ctnnb1 Gsk3b ---| Ctnnb1 Ctnnb1 ---> translocated Ctnnb1 Wif1 ---- Wnt_ligands_secreted translocated Ctnnb1 ---> Wnt target genes Porcn ---> Wnt_ligands Wls ---- Wnt_ligands Wnt_ligands ---> Wnt_ligands_secreted Fzd_receptors ---- Ndp Axin2 Axin1 ---- Csnk1a1 Tcf_factors Csnk1a1 ---> Axin1 Ctnnb1 Gsk3b ---> Axin1
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Genes in Pathway:

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Wnt signaling, canonical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC, WNT signaling pathway regulator JBrowse link 18 27,011,710 27,106,323 RGD:2293188
RGD:6484113
G Axin1 axin 1 RGD:2293188
RGD:6484113
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:2293188
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:2293188
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6484113
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:2302032
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:2293188
G Csnk1g1 casein kinase 1, gamma 1 JBrowse link 8 71,533,372 71,688,483 RGD:2293188
RGD:6484113
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1581696
RGD:7242068
RGD:6484113
RGD:2293188
G Cul3 cullin 3 JBrowse link 9 86,044,485 86,129,066 RGD:6484113
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:2293188
RGD:2301921
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 JBrowse link 2 237,148,918 237,240,883 RGD:2301921
G Dkk4 dickkopf WNT signaling pathway inhibitor 4 JBrowse link 16 74,260,551 74,264,142 RGD:2301921
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:1581696
RGD:6484113
G Dvl2 dishevelled segment polarity protein 2 JBrowse link 10 56,609,810 56,619,269 RGD:6484113
G Dvl3 dishevelled segment polarity protein 3 JBrowse link 11 84,051,177 84,068,479 RGD:6484113
G Frzb frizzled-related protein JBrowse link 3 67,635,604 67,668,772 RGD:7365107
G Fzd1 frizzled class receptor 1 JBrowse link 4 26,470,864 26,475,262 RGD:2293491
G Fzd5 frizzled class receptor 5 JBrowse link 9 71,443,784 71,445,541 RGD:6484113
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:6484113
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1581696
RGD:7242068
RGD:6484113
RGD:2293188
G Klhl12 kelch-like family member 12 JBrowse link 13 51,280,933 51,314,753 RGD:6484113
G Kremen1 kringle containing transmembrane protein 1 JBrowse link 14 85,441,209 85,503,661 RGD:2301921
G Kremen2 kringle containing transmembrane protein 2 JBrowse link 10 13,076,042 13,081,210 RGD:2301921
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:2293188
RGD:2301908
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 JBrowse link 3 101,051,960 101,152,119 RGD:7365107
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 JBrowse link 7 58,447,097 58,587,787 RGD:7365107
G Lrp5 LDL receptor related protein 5 JBrowse link 1 218,816,833 218,920,147 RGD:2293188
RGD:2293491
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:2293188
RGD:6484113
G Ndp NDP, norrin cystine knot growth factor JBrowse link X 6,791,090 6,815,586 RGD:7365107
G Nkd2 naked cuticle homolog 2 JBrowse link 1 32,054,390 32,085,416 RGD:6484113
G Pi4k2a phosphatidylinositol 4-kinase type 2 alpha JBrowse link 1 261,337,594 261,362,509 RGD:6484113
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta JBrowse link 1 242,168,462 242,441,247 RGD:6484113
G Porcn porcupine O-acyltransferase JBrowse link X 15,035,569 15,048,440 RGD:7365109
G Ppp2r5a protein phosphatase 2, regulatory subunit B', alpha JBrowse link 13 110,033,550 110,077,946 RGD:6484113
G Ranbp3 RAN binding protein 3 JBrowse link 9 10,344,190 10,381,415 RGD:6484113
G Rnf43 ring finger protein 43 JBrowse link 10 74,956,411 75,028,951 RGD:7365105
G Rspo1 R-spondin 1 JBrowse link 5 142,986,526 143,007,847 RGD:7365105
G Rspo2 R-spondin 2 JBrowse link 7 81,919,911 82,059,659 RGD:7365105
G Rspo3 R-spondin 3 JBrowse link 1 30,681,648 30,768,038 RGD:7365105
G Rspo4 R-spondin 4 JBrowse link 3 147,358,690 147,391,719 RGD:7365105
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:7365107
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:7365107
G Sfrp4 secreted frizzled-related protein 4 JBrowse link 17 47,383,983 47,394,065 RGD:7365107
G Sfrp5 secreted frizzled-related protein 5 JBrowse link 1 261,442,108 261,446,570 RGD:7365107
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 8 22,648,323 22,739,468 RGD:2302032
G Sost sclerostin JBrowse link 10 89,897,087 89,900,131 RGD:7365107
G Sostdc1 sclerostin domain containing 1 JBrowse link 6 55,812,820 55,816,994 RGD:7365107
G Tcf7 transcription factor 7 JBrowse link 10 37,616,033 37,646,027 RGD:2301908
G Tcf7l1 transcription factor 7 like 1 JBrowse link 4 100,492,796 100,660,401 RGD:2301908
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:2301908
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1304267
G Wif1 Wnt inhibitory factor 1 JBrowse link 7 63,094,955 63,165,158 RGD:2293188
G Wls wntless Wnt ligand secretion mediator JBrowse link 2 266,315,036 266,431,220 RGD:7365109
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:2313743
RGD:13209023
G Wnt10a Wnt family member 10A JBrowse link 9 82,053,581 82,066,047 RGD:2300202
RGD:2313743
G Wnt10b Wnt family member 10B JBrowse link 7 140,448,284 140,466,159 RGD:2300029
RGD:2313743
G Wnt11 Wnt family member 11 JBrowse link 1 163,794,136 163,813,756 RGD:2313743
G Wnt16 Wnt family member 16 JBrowse link 4 49,369,246 49,388,156 RGD:2313743
G Wnt2 Wnt family member 2 JBrowse link 4 45,286,845 45,332,899 RGD:2313743
G Wnt2b Wnt family member 2B JBrowse link 2 207,433,771 207,457,094 RGD:2313743
G Wnt3 Wnt family member 3 JBrowse link 10 91,830,709 91,874,907 RGD:2313743
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:2300202
RGD:6484113
RGD:2313743
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:2313743
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:2313743
G Wnt5b Wnt family member 5B JBrowse link 4 151,500,962 151,516,894 RGD:2313743
G Wnt6 Wnt family member 6 JBrowse link 9 82,033,543 82,047,172 RGD:2313743
G Wnt7a Wnt family member 7A JBrowse link 4 122,994,425 123,040,609 RGD:1601222
RGD:2313743
G Wnt7b Wnt family member 7B JBrowse link 7 126,423,418 126,465,724 RGD:1601222
RGD:2313743
RGD:2293491
G Wnt8a Wnt family member 8A JBrowse link 18 27,331,236 27,336,829 RGD:2313743
G Wnt8b Wnt family member 8B JBrowse link 1 264,244,150 264,266,136 RGD:2313743
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:2300156
RGD:2313743
G Wnt9b Wnt family member 9B JBrowse link 10 91,785,892 91,808,061 RGD:2313743
G Znrf3 zinc and ring finger 3 JBrowse link 14 85,527,099 85,586,294 RGD:7365105
altered Wnt signaling, canonical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC, WNT signaling pathway regulator JBrowse link 18 27,011,710 27,106,323 RGD:2293188
G Axin1 axin 1 RGD:2293188
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:2293188
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:2293188
RGD:4143515
G Lrp5 LDL receptor related protein 5 JBrowse link 1 218,816,833 218,920,147 RGD:2293188
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:5490966
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:5490966

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassDkk membersdickkopf homolog family of proteins
Functional ClassDvlsdisheveled, dsh homolog family of proteins
Functional ClassFzd_receptorsfrizzled homolog family of proteins
Functional ClassRSPOsRSPO family of agonists
Functional ClasssFRPssFRP family of antagonists
Functional ClassTcf_factorsTcf family of transcription factors
Functional ClassWnt_ligandswingless related family of proteins

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Wnt signaling, canonical pathway
Disease TermsGene Symbols
46,XX Sex Reversal with Dysgenesis of Kidneys, Adrenals, and LungsWnt4
Aberrant Crypt FociApc , Ctnnb1 , Gsk3b
Abnormalities, Drug-InducedWnt11
Abnormalities, MultipleCtnnb1 , Gsk3b
Acute Kidney InjuryGsk3b , Wnt4
Acute Lung InjuryCav1
AdenocarcinomaApc , Ctnnb1 , Tcf7l2
Adenocarcinoma of LungApc , Crebbp , Ctnnb1
ADENOCARCINOMA OF STOMACHCrebbp , Ctnnb1
Adenocarcinoma, ColorectalGsk3b
Adenocarcinoma, ProstaticCtnnb1
AdenomaApc , Ctnnb1
Adenoma, ColorectalApc
Adenoma, Liver CellCtnnb1
Adenomatous Polyposis ColiApc
Adenomatous Polyposis Coli, AttenuatedApc
Adenomatous PolypsApc
Adrenal Gland NeoplasmsCtnnb1
Adrenocortical CarcinomaCtnnb1 , Znrf3
Al Awadi SyndromeWnt7a
Alzheimer DiseaseApc , Crebbp , Csnk1a1 , Ctnnb1 , Gsk3a , Gsk3b , Tsc2
Amyotrophic Lateral SclerosisGsk3a , Gsk3b
Amyotrophic Lateral Sclerosis 1Crebbp , Wnt7a
Anemia, MacrocyticApc
AngiomyolipomaTsc2
AnodontiaAxin2 , Dkk1
Anonychia congenitaRspo4
Aortic Aneurysm, AbdominalCav1
Arthritis, ExperimentalGsk3b , Sfrp4
Arthritis, JuvenileTcf7l2
AtherosclerosisCav1
Atrial FibrillationCav1 , Wnt8a
Attention Deficit Disorder with HyperactivityCrebbp
Autism Spectrum DisorderTsc2
Autistic DisorderApc , Tsc2 , Wnt2
Bipolar DisorderGsk3a , Gsk3b
Bladder ExstrophyFzd5 , Wnt10a , Wnt11 , Wnt3 , Wnt6 , Wnt7a
bladder urothelial carcinomaCrebbp , Ctnnb1
Bone Diseases, MetabolicDkk1 , Lrp5
BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 17Lgr4
Brain DiseasesTsc2
Brain InjuriesGsk3b
Brain IschemiaCav1
Breast NeoplasmsApc , Cav1 , Ctnnb1 , Dkk1 , Fzd1 , Rspo3 , Sfrp1 , Sfrp2 , Sfrp5 , Tsc2 , Wif1 , Wnt10b , Wnt2 , Wnt7b , Wnt9a
Burkitt LymphomaSmarca4
BurnsGsk3b
CalcinosisCtnnb1
Carcinoma in SituCtnnb1 , Sfrp1
Carcinoma, Acinar CellApc
Carcinoma, Adenoid CysticCrebbp , Wnt5b
Carcinoma, EndometrioidCtnnb1 , Wif1
Carcinoma, HepatocellularApc , Axin1 , Crebbp , Ctnnb1
Carcinoma, LobularCtnnb1
Carcinoma, Non-Small-Cell LungApc
Carcinoma, Pancreatic DuctalTsc2
Carcinoma, Renal CellApc , Cav1 , Ctnnb1 , Sfrp1 , Sfrp2 , Tsc2 , Wif1 , Wnt11
Carcinoma, Small CellSmarca4 , Wif1
Carcinoma, Squamous CellCav1 , Crebbp , Tsc2
Carcinoma, Squamous Cell of Head and NeckCrebbp , Ctnnb1
Carcinoma, Transitional CellApc , Cav1 , Crebbp , Ctnnb1
CardiomegalyCav1 , Gsk3b
Cardiomyopathy, DilatedGsk3a
Cardiomyopathy, HypertrophicCtnnb1
Caudal Duplication AnomalyAxin1
Cecal NeoplasmsCtnnb1
Cell Transformation, NeoplasticApc , Wnt5a
Ceroid Lipofuscinosis, Neuronal, 6Gsk3b
Chemical and Drug Induced Liver InjuryCtnnb1
CholangiocarcinomaApc , Rnf43
Coats DiseaseNdp
Coffin-Siris SyndromeSmarca4
Cognition DisordersGsk3b
colon cancerApc , Axin2 , Ctnnb1
Colonic NeoplasmsApc , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Lgr5 , Tcf7l2
colorectal cancerApc , Axin2 , Ctnnb1 , Tcf7l2
Colorectal NeoplasmsApc , Axin1 , Axin2 , Crebbp , Ctnnb1 , Lgr5 , Rnf43 , Sfrp1 , Sfrp2 , Sfrp4 , Sfrp5 , Tcf7l2 , Wif1
Colorectal Neoplasms, Hereditary NonpolyposisApc
Coronary Artery Disease, Autosomal Dominant 2Lrp6
Coronary DiseaseTcf7l2
Craniodiaphyseal Dysplasia, Autosomal DominantSost
Craniofacial AbnormalitiesCsnk1a1 , Ctnnb1
CraniopharyngiomaCtnnb1
Crohn DiseaseTcf7
Currarino TriadDvl3
Depressive DisorderGsk3a , Gsk3b
Dermal FibrosisCav1
Desmoid Disease, HereditaryApc , Ctnnb1
Diabetes MellitusCav1 , Tcf7l2
Diabetes Mellitus, ExperimentalCav1 , Gsk3a , Smarca4 , Tsc2
Diabetes Mellitus, Type 2Gsk3b , Sfrp4 , Tcf7l2
Diabetes, GestationalTcf7l2
Diabetic NephropathiesDkk1 , Tcf7l2
Diabetic NeuropathiesCav1
DiGeorge SyndromeDvl1
Digestive System NeoplasmsApc
DiseaseCtnnb1
Disease Models, AnimalWnt11
DwarfismWnt4
ECTODERMAL DYSPLASIA 13, HAIR/TOOTH TYPEKremen1
EctromeliaWnt3
EmphysemaPpp2r5a
Endodermal Sinus TumorCtnnb1 , Wnt2b
Endometrial NeoplasmsApc , Axin2 , Ctnnb1 , Gsk3b , Rnf43 , Wnt2 , Wnt3 , Wnt4 , Wnt5a
EndometriosisDkk1
EpilepsyTsc2
Esophageal NeoplasmsCtnnb1 , Wif1
Esophageal Squamous Cell CarcinomaCrebbp , Ctnnb1
Exfoliation SyndromeCav1
Exudative vitreoretinopathy 1Ctnnb1 , Lrp5
Exudative Vitreoretinopathy 2, X-LinkedNdp
Exudative Vitreoretinopathy 4Lrp5
Exudative Vitreoretinopathy, Familial, X-Linked RecessiveNdp
Eye AbnormalitiesApc
Eye Diseases, HereditaryNdp
Familial Exudative VitreoretinopathyLrp5 , Ndp
Familial Primary Pulmonary HypertensionCav1
Female Urogenital DiseasesWnt4 , Wnt5a , Wnt7a
Femoral FracturesDkk1 , Lef1
Femur Head NecrosisLrp5
FibroadenomaWnt2 , Wnt4
Fibromatosis, AbdominalApc
Fibromatosis, AggressiveApc
Focal Cortical Dysplasia of TaylorTsc2
Focal Dermal HypoplasiaPorcn
Fractures, BoneDkk1 , Lrp5
Fuhrmann SyndromeWnt7a
Gallbladder NeoplasmsApc
Gardner SyndromeApc
Gastrointestinal HemorrhageApc
Gastrointestinal NeoplasmsApc
Genetic Diseases, InbornCav1 , Crebbp , Ctnnb1 , Lrp5 , Smarca4 , Wnt10a
GlaucomaCrebbp
Glaucoma, Open-AngleCav1
Glaucoma, Primary Open AngleCav1
GlioblastomaApc , Crebbp
GliomaCav1
Granulosa Cell TumorCtnnb1 , Wif1
HamartomaTsc2
Hearing Loss, Cisplatin-InducedGsk3b
Heart FailureGsk3b
Heart Septal Defects, VentricularSmarca4
Heart Valve DiseasesLrp5
HemangiomaTsc2
HemangiosarcomaCtnnb1
HemorrhageCav1
Hepatitis, AcuteTsc2
HepatoblastomaApc , Ctnnb1
Hepatoblastoma Caused By Somatic MutationApc , Ctnnb1
Hernias, Diaphragmatic, CongenitalWnt11
High MyopiaNdp
Hirschsprung DiseaseTsc2 , Wnt8b
Hirschsprung Disease 1Crebbp , Tsc2
Huntington DiseaseCrebbp
Hypercholesterolemia, FamilialSmarca4
HyperlipidemiasApc
HyperplasiaApc , Cav1 , Tcf7l2
HypertensionCav1 , Gsk3b
Hypertension, PulmonaryCav1
Hypertrophy, Left VentricularGsk3a , Smarca4
HypogonadismTsc2
HypothyroidismCav1 , Wnt3a
Idiopathic Hypogonadotropic HypogonadismTsc2
InfectionCtnnb1
Infertility, FemaleTsc2
InflammationTsc2
Inflammatory Bowel DiseasesApc , Sfrp1 , Sfrp2
Insulin ResistanceTcf7l2
Intellectual DisabilityApc , Tsc2
Intestinal NeoplasmsApc , Ctnnb1 , Gsk3b
Intestinal PolypsApc
Ischemic Attack, TransientCav1
Juvenile osteoporosisLrp5
Kabuki Syndrome 2Ndp
Keratoderma, PalmoplantarWnt10a
Kidney DiseasesWnt4
Kidney NeoplasmsTsc2
Leber Congenital AmaurosisLrp5
LeiomyomaCav1 , Sfrp1 , Tsc2 , Wnt5b , Wnt7a
Leukemia, Lymphocytic, Chronic, B-CellLef1
Leukemia, Myeloid, AcuteCrebbp , Tsc2
Leukemia-Lymphoma, Adult T-CellCsnk1a1
Leukocyte Adhesion Deficiency Type 1Tsc2
LeukocytosisApc
Lipodystrophy with Congenital Cataracts and NeurodegenerationCav1
Lipodystrophy, Congenital Generalized, Type 3Cav1
Lipodystrophy, Familial PartialCav1
liver cancerApc , Axin1 , Crebbp , Ctnnb1
Liver CirrhosisCtnnb1
Liver Cirrhosis, ExperimentalCav1 , Lrp6 , Wls
Liver Diseases, AlcoholicCav1
Liver Diseases, ParasiticRnf43
Liver NeoplasmsApc , Axin1 , Crebbp , Ctnnb1
Liver Neoplasms, ExperimentalCtnnb1
Low Tension GlaucomaCav1
Lung NeoplasmsApc , Ctnnb1 , Smarca4 , Wnt5a
Lupus Erythematosus, SystemicTcf7
LymphangioleiomyomatosisTsc2
Lymphatic MetastasisCav1 , Ctnnb1 , Tsc2
Lymphoma, FollicularCrebbp
Lymphoma, Mantle-CellCtnnb1 , Gsk3b , Wnt10a , Wnt3
Mammary Neoplasms, AnimalApc , Wnt1 , Wnt3 , Wnt6
Mammary Neoplasms, ExperimentalCav1 , Ctnnb1 , Wnt1 , Wnt2 , Wnt3 , Wnt3a , Wnt5b , Wnt6 , Wnt7a , Wnt7b
MedulloblastomaApc , Crebbp , Ctnnb1 , Smarca4 , Tsc2
MelanomaCav1 , Crebbp , Ctnnb1 , Cul3
Melanoma, Cutaneous Malignant, Susceptibility To, 1Ctnnb1
Mental DisordersDvl1
Mental Retardation, Autosomal Dominant 16Smarca4
Mental Retardation, Autosomal Dominant 19Ctnnb1
MesotheliomaApc
Mesothelioma, MalignantCtnnb1 , Wnt3
Metabolic Syndrome XLrp6
MetaplasiaAxin2
Microphthalmia, Syndromic 1Sfrp2 , Wnt7a
MicrophthalmosLrp5
Miyoshi MyopathyApc
Monoclonal B-Cell LymphocytosisApc
Mouth NeoplasmsTsc2
Mullerian Aplasia and HyperandrogenismWnt4
Multiple SclerosisCav1
Muscular AtrophyCtnnb1 , Gsk3b
Muscular Dystrophy, Limb-Girdle, Type 2BApc
Myocardial InfarctionDvl1 , Gsk3b , Sfrp2
Myocardial IschemiaSfrp4
Myocardial Reperfusion InjuryGsk3b , Sfrp2
Myocarditis, Autoimmune, ExperimentalCav1
Myopathy, Distal, with Anterior Tibial OnsetApc
Myositis, Inclusion BodyCsnk1a1
Nasopharyngeal NeoplasmsWif1
Neoplasm InvasivenessCtnnb1
Neoplasm MetastasisCav1 , Ctnnb1
NeoplasmsApc , Ctnnb1
Neoplasms, Germ Cell and EmbryonalLrp6
Neoplastic Syndromes, HereditaryApc , Axin2 , Tsc2
Nephrogenic Fibrosing DermopathyCav1
Nerve DegenerationCtnnb1 , Tsc2
Neuritis, Autoimmune, ExperimentalCav1
NeuroblastomaTsc2
Neurodevelopmental DisordersCtnnb1 , Cul3 , Tcf7l2
Neuroma, AcousticCav1
Niemann-Pick Disease, Type BApc
No-Reflow PhenomenonCtnnb1
Norrie DiseaseNdp
ObesityCav1 , Smarca4 , Wnt10b , Wnt3a
Odontoonychodermal DysplasiaWnt10a
Oligodontia-Colorectal Cancer SyndromeAxin2
Orofacial Cleft 1Lrp6
Osseous Heteroplasia, ProgressiveCtnnb1
OsteoarthritisCav1 , Frzb
Osteoarthritis, KneeCtnnb1 , Dkk1
Osteoarthritis, SpineLrp5
OsteochondrodysplasiasLrp5 , Sost
Osteogenesis ImperfectaLrp5
Osteogenesis Imperfecta, Type XVWnt1
OsteopetrosisLrp5
Osteopetrosis Autosomal Dominant Type 1Lrp5
OsteoporosisLrp5 , Wnt1
Osteoporosis, PostmenopausalLrp5
Osteoporosis-Pseudoglioma SyndromeLrp5
OsteosarcomaTsc2
ovarian cancerCtnnb1
Ovarian CystsSfrp4
Ovarian NeoplasmsCav1 , Ctnnb1 , Gsk3b , Lef1 , Smarca4 , Wnt7a
ovary epithelial cancer Rspo1 , Wnt4
Oxygen-Induced RetinopathyNdp
Palmoplantar Hyperkeratosis and True HermaphroditismRspo1
Palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversalRspo1
Pancreatic AdenocarcinomaCtnnb1
Pancreatic NeoplasmsApc , Ctnnb1 , Smarca4 , Tcf7l2 , Tsc2 , Wnt9a , Znrf3
Parkinson DiseaseGsk3b
Parkinsonian DisordersGsk3a
Periampullary AdenomaApc
Peritoneal NeoplasmsCtnnb1
PeritonitisGsk3b
Persistent Hyperplastic Primary VitreousNdp
Phyllodes TumorCtnnb1
PilomatrixomaCtnnb1
Pleomorphic Xanthoastrocytoma Cav1 , Fzd1 , Sfrp4 , Sostdc1 , Wnt16 , Wnt2
PoisoningGsk3b
polycystic kidney disease 1Lrp5
Polycystic Kidney DiseasesLrp5
Polycystic Kidney, Autosomal DominantLrp5
Potter Type III Polycystic Kidney DiseaseLrp5
Precancerous ConditionsTsc2
Precursor Cell Lymphoblastic Leukemia-LymphomaCrebbp
Precursor T-Cell Lymphoblastic Leukemia-LymphomaSmarca4
prostate cancerCtnnb1 , Lrp6
Prostatic NeoplasmsApc , Cav1 , Crebbp , Ctnnb1 , Gsk3b , Lrp6 , Smarca4 , Wif1 , Wnt11 , Wnt2 , Wnt4
PseudohypoaldosteronismCul3
Pseudohypoaldosteronism, Type IIECul3
PsoriasisCav1
Pulmonary FibrosisCav1
Pulmonary Hypertension, Primary, 3Cav1
Pyle DiseaseSfrp4
Rectal NeoplasmsApc
Reperfusion InjuryCav1 , Wnt3a
Respiratory Distress Syndrome, AdultApc
Retinal DystrophiesLrp5
Retinal Nonattachment, Nonsyndromic CongenitalNdp
Retinal TelangiectasisNdp
Retinopathy of PrematurityNdp
Rhabdoid Tumor Predisposition Syndrome 2Smarca4
Robinow Syndrome, Autosomal DominantDvl1 , Dvl3 , Wnt5a
ROBINOW SYNDROME, AUTOSOMAL DOMINANT 2Dvl1
ROBINOW SYNDROME, AUTOSOMAL DOMINANT 3Dvl3
Rubinstein-Taybi SyndromeCrebbp
Salivary Gland NeoplasmsWnt5b
SarcomaSmarca4
SarcopeniaCav1
SchizophreniaGsk3a , Gsk3b , Lgr4
Schopf-Schulz-Passarge SyndromeWnt10a
Sciatic NeuropathyCav1
Scleroderma, LimitedCav1
Scleroderma, SystemicCav1
SclerosteosisSost
sclerosteosis 1Sost
ScoliosisCrebbp
Sebaceous Gland NeoplasmsLef1
SeizuresDkk1 , Tsc2 , Wnt2
SepsisGsk3b
Serrated PolyposisRnf43
SESSILE SERRATED POLYPOSIS CANCER SYNDROMERnf43
Sezary SyndromeCrebbp , Smarca4
Skin NeoplasmsCtnnb1
Small Cell Lung CarcinomaCrebbp , Smarca4
Smith-Magenis SyndromeAxin2 , Rnf43 , Sost , Wnt3 , Wnt9b
SOST-related sclerosing bone dysplasia (DOID:0080)Lrp5
Spasms, InfantileTsc2
Spinal Cord InjuriesCav1 , Lrp5
Spinocerebellar Ataxia, Autosomal Recessive 8Apc
SplenomegalyApc
Split-Hand/Foot Malformation 6Wnt10b
Squamous Cell Carcinoma of the LungCrebbp , Ctnnb1
Status EpilepticusGsk3b
Stevens-Johnson SyndromeCav1 , Ctnnb1
Stomach NeoplasmsApc , Cav1 , Ctnnb1 , Rnf43 , Wif1
StrokeCtnnb1
TauopathiesGsk3b
TendinopathyLrp5
TeratomaCtnnb1 , Wnt2b
Tetra-Amelia Autosomal RecessiveWnt3
Thoracic NeoplasmsSmarca4
Thumb DeformityCrebbp
Thyroid NeoplasmsTcf7l1
Tooth AbnormalitiesLrp6
tooth agenesisLrp6
Tooth agenesis, selective, 4Wnt10a
Tooth agenesis, selective, 7Lrp6
TOOTH AGENESIS, SELECTIVE, 8Wnt10b
Triple Negative Breast NeoplasmsLrp6
Tuberous SclerosisTsc2
Tuberous Sclerosis 1Tsc2
Tuberous Sclerosis 2Tsc2
Tumor Predisposition SyndromeApc , Tsc2
Turcot SyndromeApc
Urinary Bladder NeoplasmsCav1 , Crebbp , Ctnnb1 , Wif1 , Wnt7b
Urogenital AbnormalitiesWnt4
Urogenital NeoplasmsWnt7a
Urologic NeoplasmsWnt2
Uterine Cervical NeoplasmsCrebbp , Ctnnb1 , Wnt2 , Wnt5a
Uterine NeoplasmsCtnnb1
Van Buchem Disease Type 2Lrp5
Vascular CalcificationCtnnb1
Vitreoretinopathy, ProliferativeLrp5
Weight GainCav1
Wilms TumorCtnnb1 , Wif1
Worth SyndromeLrp5
Pathway Annotations Associated with Genes in the Wnt signaling, canonical pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayLef1 , Tcf7 , Tcf7l2
aldosterone signaling pathwayCrebbp
altered SWI/SNF family mediated chromatin remodeling pathwaySmarca4
altered Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Ctnnb1 , Lrp5 , Tcf7l2 , Wnt9a
Alzheimer disease pathwayGsk3b
androgen signaling pathwayCrebbp
arrhythmogenic right ventricular cardiomyopathy pathwayCtnnb1 , Lef1 , Tcf7 , Tcf7l2
B cell receptor signaling pathwayGsk3b
basal cell carcinoma pathwayApc , Axin1 , Axin2 , Ctnnb1 , Dvl1 , Dvl3 , Fzd1 , Fzd5 , Gsk3b , Lef1 , Tcf7 , Tcf7l2 , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
Bone morphogenetic proteins signaling pathwayGsk3b , Sostdc1
cell cycle pathway, mitoticCrebbp , Gsk3b
chemokine mediated signaling pathwayGsk3a , Gsk3b
colorectal cancer pathwayApc , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf7 , Tcf7l2
cortisol signaling pathwayCrebbp , Smarca4
dopamine signaling pathwayCsnk1a1
E-cadherin signaling pathwayCtnnb1
endocytosis pathwayCav1 , Pip5k1b
endometrial cancer pathwayApc , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf7 , Tcf7l2
epidermal growth factor/neuregulin signaling pathwayGsk3b
estrogen signaling pathwayCrebbp
Fc gamma receptor mediated signaling pathwayPip5k1b
forkhead class A signaling pathwayCrebbp
glycogen biosynthetic pathwayGsk3a , Gsk3b
Hedgehog signaling pathwayBtrc , Crebbp , Csnk1a1 , Csnk1g1 , Gsk3b , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
hepatitis C virus infection pathwayGsk3b
histone modification pathwayCrebbp , Smarca4
Huntington disease pathwayCrebbp
hypoxia inducible factor pathwayCrebbp
influenza A virus infection pathwayCrebbp , Gsk3b
inositol phosphate metabolic pathwayPi4k2a , Pip5k1b
insulin responsive facilitative sugar transporter mediated glucose transport pathwayGsk3b
insulin signaling pathwayCav1 , Gsk3b , Tsc2
Jak-Stat signaling pathwayCrebbp
long term depressionGsk3b
long term potentiationCrebbp
measles infection pathwayGsk3b
mitogen activated protein kinase signaling pathwayTsc2
mRNA decay pathwayPpp2r5a
mTOR signaling pathwayTsc2
Mycobacterium tuberculosis infection pathwayCrebbp
myocarditis pathwayCav1
N-cadherin signaling pathwayAxin1 , Ctnnb1 , Lrp5
neddylation pathwayCul3
neurotrophic factor signaling pathwayGsk3b
Notch signaling pathwayCrebbp , Dvl1 , Dvl3
nuclear factor kappa B signaling pathwayBtrc
nuclear factor, erythroid 2 like 2 signaling pathwayBtrc , Crebbp , Cul3 , Gsk3a , Gsk3b
p53 signaling pathwayCrebbp , Csnk1a1 , Csnk1g1 , Gsk3b , Tsc2
pancreatic cancer pathwaySmarca4 , Tcf7l2 , Wnt9a
phosphatidylinositol 3-kinase signaling pathwayPi4k2a , Pip5k1b
phosphatidylinositol 3-kinase-Akt signaling pathwayGsk3a , Gsk3b
platelet-derived growth factor signaling pathwayCav1
prostate cancer pathwayCrebbp , Ctnnb1 , Gsk3b , Lef1 , Tcf7 , Tcf7l2
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul3
Reelin signaling pathwayGsk3b
renal cell cancer pathwayCrebbp
reverse cholesterol transport pathwayCav1
RNA polymerase I transcription pathwayCrebbp
SWI/SNF family mediated chromatin remodeling pathwaySmarca4
T cell receptor signaling pathwayGsk3b
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayTsc2
the Wnt/calcium signaling pathwayWnt11
thyroid cancer pathwayCtnnb1 , Lef1 , Tcf7 , Tcf7l2
transforming growth factor-beta signaling pathwayTsc2
transforming growth factor-beta Smad dependent signaling pathwayAxin1 , Cav1 , Crebbp , Ctnnb1
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp
tumor necrosis factor mediated signaling pathwayCav1
type II interferon signaling pathwayCrebbp
ubiquitin/proteasome degradation pathwayBtrc , Cul3
vascular endothelial growth factor signaling pathwayCav1 , Ctnnb1
Wnt signaling pathwayApc , Axin1 , Axin2 , Btrc , Crebbp , Csnk1a1 , Ctnnb1 , Dkk1 , Dkk2 , Dkk4 , Dvl1 , Dvl2 , Dvl3 , Fzd1 , Fzd5 , Gsk3b , Lef1 , Lrp5 , Lrp6 , Nkd2 , Porcn , Ppp2r5a , Sfrp1 , Sfrp2 , Sfrp4 , Sfrp5 , Tcf7 , Tcf7l2 , Wif1 , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Btrc , Cav1 , Crebbp , Csnk1a1 , Csnk1g1 , Ctnnb1 , Cul3 , Dkk1 , Dkk2 , Dkk4 , Dvl1 , Dvl2 , Dvl3 , Frzb , Fzd1 , Fzd5 , Gsk3a , Gsk3b , Klhl12 , Kremen1 , Kremen2 , Lef1 , Lgr4 , Lgr5 , Lrp5 , Lrp6 , Ndp , Nkd2 , Pi4k2a , Pip5k1b , Porcn , Ppp2r5a , Ranbp3 , Rnf43 , Rspo1 , Rspo2 , Rspo3 , Rspo4 , Sfrp1 , Sfrp2 , Sfrp4 , Sfrp5 , Smarca4 , Sost , Sostdc1 , Tcf7 , Tcf7l1 , Tcf7l2 , Tsc2 , Wif1 , Wls , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b , Znrf3
Wnt signaling, non-canonical pathwayCsnk1a1 , Dvl1 , Dvl2 , Dvl3 , Fzd5 , Wnt5a , Wnt7a
Wnt signaling, the planar cell polarity pathwayDvl1 , Dvl2 , Wnt7b
Phenotype Annotations Associated with Genes in the Wnt signaling, canonical pathway

References Associated with the Wnt signaling, canonical pathway:

Ontology Path Diagram:

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