EPIDERMAL GROWTH FACTOR/NEUREGULIN SIGNALING PATHWAY (PW:0000170)
Description
The epidermal growth factor/neuregulin signaling pathway plays a central role in the regulation of cell growth, differentiation, proliferation and survival. At least eleven ligands bind to four receptors to activate downstream signaling pathways, primarily the Raf/Mek/Erk MAPK and the phosphatidylinositol 3-Akt cascades (reports point to activation of Stat proteins in certain cancer cell lines). The ligands are type 1 transmembrane proteins whose extracellular domain must be cleaved in order to free the active growth factors, a process known as 'ectodomain shedding'. The 'sheddases' are members of the Adam family of metalloproteases. The mechanism of their activation is not well understood but a possible involvement of GPCR and/or protein kinase C has been reported. The ligands contain a consensus sequence known as the EGF motif; it harbors six cysteines forming three disulfide bonds and is essential for receptor binding. The four transmembrane glycoprotein receptors contain an extracellular ligand binding domain, a small intracellular juxtadomain followed by the tyrosine kinase domain and the C-terminal tail containing the docking sites for phosphotyrosine-binding proteins. The extracellular domain is composed of subdomains I through IV, of which I and III are leucine-rich repeats involved in ligand binding and II and IV are laminin-like, cysteine-rich domains. Of the four receptors, the prototypical Egfr and Erbb4 are autonomous in that they possess both ligand binding and tyrosine kinase activities. Erbb2 does not bind ligands and Erbb3 lacks kinase activity. Receptors form homo- or heterodimers; Erbb2 is a preferred partner. Among ligands, the prototypical Egf, along with Tgf-alpha, Areg and Epgn are Egfr-specific while Hbegf, Btc and Ereg bind both Egfr and Erbb4 receptors. Neuregulins (Nrg1 to 4) are another class of ligands that bind to Erbb4 and Erbb3 receptors; at least 20 isoforms are produced via alternative splicing. Ligand binding induces conformational changes leading to stabilization of the oligomeric structure, tyrosine kinase activation and transphosphorylation of receptors. The phosphorylated residues provide docking sites for various proteins with SH2 (
src homology 2 ) and PTB (
phosphotyrosine binding ) domains. Phosphorylated Egfr and Erbb4 interact directly or via Shc1 with the adapter Grb2 to recruit Sos proteins followed by activation of Ras and the Raf/Mek/Erk cascade. Phopshorylated Erbb3 on the other hand recruits the regulatory p85 subunit of the PI3 lipid kinase leading to allosteric activation of the catalytic subunit and the enfolding of the PI3K-Akt pathway. Erbb2 (ligand defective) and Erbb3 (kinase defective) form a potent signaling heterodimer that activates both pathways. Egfr activity is attenuated and/or inhibited by dephosphorylation and ubiquitination; examples include Ptprj and Cbl. Egfr and Erbb2 are over-expressed and/or amplified in several cancers.
To access the ontology report for annotations, GViewer and downloads, click here. [Click to see the ontology report for related GO term -
GO:0007173 , Kegg map -
map04012 and entry at Reactome -
REACT_9417.3 ]
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Pathway Diagram:
Genes in Pathway:
G
Abl1
ABL proto-oncogene 1, non-receptor tyrosine kinase
IEA
KEGG
rno:04012
NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
G
Abl2
ABL proto-oncogene 2, non-receptor tyrosine kinase
IEA
KEGG
rno:04012
NCBI chr13:68,673,702...68,770,846
Ensembl chr13:68,673,722...68,839,742
G
Adam10
ADAM metallopeptidase domain 10
ISO
RGD
PMID:15688065
RGD:2317976
NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
G
Adam12
ADAM metallopeptidase domain 12
ISO
RGD
PMID:15688065
RGD:2317976
NCBI chr 1:188,686,984...189,014,206
Ensembl chr 1:188,686,989...189,020,667
G
Adam17
ADAM metallopeptidase domain 17
ISO
RGD
PMID:15688065
RGD:2317976
NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
G
Adam19
ADAM metallopeptidase domain 19
ISO
RGD
PMID:15688065
RGD:2317976
NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105
G
Adam9
ADAM metallopeptidase domain 9
ISO
RGD
PMID:15688065
RGD:2317976
NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917
G
Akt1
AKT serine/threonine kinase 1
IEA
KEGG
rno:04012
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Akt2
AKT serine/threonine kinase 2
IEA
KEGG
rno:04012
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
G
Akt3
AKT serine/threonine kinase 3
IEA
KEGG
rno:04012
NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
G
Areg
amphiregulin
IDA ISO IEA
PID KEGG RGD
PMID:15509566 PMID:15982853
PID:200159 rno:04012, RGD:1578718 , RGD:2317963
NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
G
Bad
BCL2-associated agonist of cell death
IEA
KEGG
rno:04012
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
G
Braf
B-Raf proto-oncogene, serine/threonine kinase
IEA
KEGG
rno:04012
NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
G
Btc
betacellulin
ISO IEA IDA
KEGG PID RGD
PMID:15982853 PMID:11564606
PID:200159 rno:04012, RGD:2317963 , RGD:2324625
NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049
G
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
IEA
KEGG
rno:04012
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
G
Camk2b
calcium/calmodulin-dependent protein kinase II beta
IEA
KEGG
rno:04012
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
G
Camk2d
calcium/calmodulin-dependent protein kinase II delta
IEA
KEGG
rno:04012
NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
G
Camk2g
calcium/calmodulin-dependent protein kinase II gamma
IEA
KEGG
rno:04012
NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050
G
Cbl
Cbl proto-oncogene
ISO IEA
KEGG RGD
PMID:16829981
rno:04012, RGD:2317988
NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176
G
Cblb
Cbl proto-oncogene B
IEA
KEGG
rno:04012
NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
G
Cblc
Cbl proto-oncogene C
IEA
KEGG
rno:04012
NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
IEA
KEGG
rno:04012
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
IEA
KEGG
rno:04012
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
G
Crk
CRK proto-oncogene, adaptor protein
IEA
KEGG
rno:04012
NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
G
Crkl
CRK like proto-oncogene, adaptor protein
IEA
KEGG
rno:04012
NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238
G
Egf
epidermal growth factor
IDA IEA ISO
KEGG PID RGD
PMID:2260661 PMID:15982853
PID:200101 PID:200159 rno:04012, RGD:1626483 , RGD:2317963
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
G
Egfr
epidermal growth factor receptor
IMP IEA ISO
KEGG PID RGD
PMID:16648628 PMID:15486316 PMID:15982853
PID:200101 PID:200159 rno:04012, RGD:1581898 , RGD:1581908 , RGD:2317963
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
G
Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
IEA
KEGG
rno:04012
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
G
Elk1
ETS transcription factor ELK1
IEA
KEGG
rno:04012
NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
G
Epgn
epithelial mitogen
ISO
RGD
PMID:15982853
RGD:2317963
NCBI chr14:17,076,774...17,084,806
Ensembl chr14:17,076,774...17,084,806
G
Erbb2
erb-b2 receptor tyrosine kinase 2
ISO IEA
KEGG PID RGD
PMID:15982853
PID:200159 rno:04012, RGD:2317963
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
G
Erbb3
erb-b2 receptor tyrosine kinase 3
IMP IEA ISO
Neuregulin stimulation of glucose transport in muscle cells
KEGG PID RGD
PMID:15007074 PMID:14711829 PMID:16829981 PMID:18519747
PID:200159 rno:04012, RGD:1642700 , RGD:2289958 , RGD:2317988 , RGD:2317965
NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
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Erbb4
erb-b2 receptor tyrosine kinase 4
ISO IEA
KEGG RGD
PMID:18519747
rno:04012, RGD:2317965
NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
G
Ereg
epiregulin
ISO IEA
KEGG PID RGD
PMID:15982853
PID:200159 rno:04012, RGD:2317963
NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
G
Gab1
GRB2-associated binding protein 1
ISO IEA
PID KEGG
PID:200101 rno:04012
NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236
G
Gnai1
G protein subunit alpha i1
ISO
PID
PID:200101
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
G
Gnai3
G protein subunit alpha i3
ISO
PID
PID:200101
NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
G
Gper1
G protein-coupled estrogen receptor 1
IMP
RGD
PMID:20445128
RGD:4892084
NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
G
Grb2
growth factor receptor bound protein 2
ISO IEA
KEGG PID RGD
PMID:16829981
PID:200101 rno:04012, RGD:2317988
NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
G
Gsk3b
glycogen synthase kinase 3 beta
IEA
KEGG
rno:04012
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Gsn
gelsolin
ISO
PID
PID:200101
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
G
Hbegf
heparin-binding EGF-like growth factor
ISO IMP IEA
PID KEGG RGD
PMID:15982853 PMID:15486316
PID:200159 rno:04012, RGD:2317963 , RGD:1581908
NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
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Hras
HRas proto-oncogene, GTPase
ISO IEA
PID KEGG
PID:200101 rno:04012
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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Hsp90aa1
heat shock protein 90 alpha family class A member 1
ISO
PID
PID:200159
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
IEA
KEGG
rno:04012
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Kras
KRAS proto-oncogene, GTPase
IEA
KEGG
rno:04012
NCBI chr 4:178,185,418...178,218,484
G
Map2k1
mitogen activated protein kinase kinase 1
IEA
KEGG
rno:04012
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
G
Map2k2
mitogen activated protein kinase kinase 2
IEA
KEGG
rno:04012
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
G
Map2k4
mitogen activated protein kinase kinase 4
IEA
KEGG
rno:04012
NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
G
Map2k7
mitogen activated protein kinase kinase 7
IEA
KEGG
rno:04012
NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222
G
Mapk1
mitogen activated protein kinase 1
ISO IEA
PID KEGG
PID:200101 rno:04012
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk10
mitogen activated protein kinase 10
IEA
KEGG
rno:04012
NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
G
Mapk3
mitogen activated protein kinase 3
ISO IEA
PID KEGG
PID:200101 rno:04012
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mapk8
mitogen-activated protein kinase 8
IEA
KEGG
rno:04012
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
G
Mapk9
mitogen-activated protein kinase 9
IEA
KEGG
rno:04012
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
G
Mtor
mechanistic target of rapamycin kinase
IEA
KEGG
rno:04012
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
G
Myc
MYC proto-oncogene, bHLH transcription factor
IEA
KEGG
rno:04012
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Nck1
NCK adaptor protein 1
ISO IEA
PID KEGG
PID:200101 rno:04012
NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300
G
Nck2
NCK adaptor protein 2
ISO IEA
PID KEGG
PID:200101 rno:04012
NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307
G
Nras
NRAS proto-oncogene, GTPase
ISO IEA
PID KEGG
PID:200101 rno:04012
NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
G
Nrg1
neuregulin 1
ISO IEA
KEGG RGD
PMID:18519747
rno:04012, RGD:2317965
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
G
Nrg2
neuregulin 2
IDA IEA ISO
KEGG PID RGD
PMID:9348101 PMID:18519747
PID:200159 rno:04012, RGD:1304015 , RGD:2317965
NCBI chr18:27,616,542...27,798,505
Ensembl chr18:27,619,661...27,798,505
G
Nrg3
neuregulin 3
ISO IEA
KEGG PID RGD
PMID:18519747
PID:200159 rno:04012, RGD:2317965
NCBI chr16:14,229,270...15,352,505
Ensembl chr16:14,235,157...15,352,368
G
Nrg4
neuregulin 4
ISO IEA
KEGG PID RGD
PMID:18519747
PID:200159 rno:04012, RGD:2317965
NCBI chr 8:55,586,253...55,677,829
Ensembl chr 8:55,592,893...55,677,483
G
Pak1
p21 (RAC1) activated kinase 1
ISO IEA
PID KEGG
PID:200101 rno:04012
NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
G
Pak2
p21 (RAC1) activated kinase 2
IEA
KEGG
rno:04012
NCBI chr11:68,707,940...68,768,816
Ensembl chr11:68,707,969...68,768,816
G
Pak3
p21 (RAC1) activated kinase 3
IEA
KEGG
rno:04012
NCBI chr X:107,116,308...107,374,342
Ensembl chr X:107,260,898...107,368,314
G
Pak4
p21 (RAC1) activated kinase 4
IEA
KEGG
rno:04012
NCBI chr 1:83,849,904...83,889,188
Ensembl chr 1:83,849,904...83,859,413
G
Pak5
p21 (RAC1) activated kinase 5
IEA
KEGG
rno:04012
NCBI chr 3:123,395,678...123,703,967
Ensembl chr 3:123,396,497...123,703,930
G
Pak6
p21 (RAC1) activated kinase 6
IEA
KEGG
rno:04012
NCBI chr 3:105,638,248...105,674,399
Ensembl chr 3:105,638,653...105,672,975
G
Pdk1
pyruvate dehydrogenase kinase 1
IMP
Neuregulin stimulation of glucose transport in muscle cells
RGD
PMID:15007074
RGD:1642700
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
G
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISO IEA
PID KEGG
PID:200101 rno:04012
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
G
Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
ISO IEA
PID KEGG
PID:200101 rno:04012
NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
G
Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
ISO IEA
PID KEGG
PID:200101 rno:04012
NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
G
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
ISO IEA
KEGG PID RGD
PMID:16829981
PID:200101 rno:04012, RGD:2317988
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
G
Pik3r2
phosphoinositide-3-kinase regulatory subunit 2
ISO IEA
PID KEGG
PID:200101 rno:04012
NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065
G
Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
ISO IEA
PID KEGG
PID:200101 rno:04012
NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
G
Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5
IEA
KEGG
rno:04012
NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374
G
Pip5k1c
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
ISO
PID
PID:200101
NCBI chr 7:8,397,406...8,426,030
Ensembl chr 7:8,397,406...8,425,988
G
Plcg1
phospholipase C, gamma 1
ISO IEA
PID KEGG
PID:200101 rno:04012
NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
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Plcg2
phospholipase C, gamma 2
IEA
KEGG
rno:04012
NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
G
Prkca
protein kinase C, alpha
IEA
KEGG
rno:04012
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
G
Prkcb
protein kinase C, beta
IEA
KEGG
rno:04012
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
G
Prkcg
protein kinase C, gamma
IEA
KEGG
rno:04012
NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
G
Prkcz
protein kinase C, zeta
IMP
Neuregulin stimulation of glucose transport in muscle cells
RGD
PMID:15007074
RGD:1642700
NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
G
Ptk2
protein tyrosine kinase 2
IEA
KEGG
rno:04012
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
G
Ptpn1
protein tyrosine phosphatase, non-receptor type 1
ISO
PID
PID:200101
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
G
Ptpn11
protein tyrosine phosphatase, non-receptor type 11
ISO
PID
PID:200101
NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
G
Ptpn6
protein tyrosine phosphatase, non-receptor type 6
ISO
PID
PID:200101
NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
G
Ptprj
protein tyrosine phosphatase, receptor type, J
ISO
RGD
PMID:16829981
RGD:2317988
NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260
G
Raf1
Raf-1 proto-oncogene, serine/threonine kinase
IEA
KEGG
rno:04012
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
G
Rasa1
RAS p21 protein activator 1
ISO
PID
PID:200101
NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854
G
Rps6kb1
ribosomal protein S6 kinase B1
IEA
KEGG
rno:04012
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
G
Rps6kb2
ribosomal protein S6 kinase B2
IEA
KEGG
rno:04012
NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078
G
Shc1
SHC adaptor protein 1
ISO IEA
KEGG RGD
PMID:16829981
rno:04012, RGD:2317988
NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
G
Shc2
SHC adaptor protein 2
IEA
KEGG
rno:04012
NCBI chr 7:10,066,705...10,088,926
Ensembl chr 7:10,066,705...10,088,926
G
Shc3
SHC adaptor protein 3
IEA
KEGG
rno:04012
NCBI chr17:13,652,247...13,772,710
Ensembl chr17:13,651,202...13,772,710
G
Shc4
SHC adaptor protein 4
IEA
KEGG
rno:04012
NCBI chr 3:112,880,598...112,974,216
Ensembl chr 3:112,880,600...112,974,366
G
Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
IEP IEA ISO
KEGG PID RGD
PMID:8577724 PMID:16829981
PID:200101 rno:04012, RGD:1581110 , RGD:2317988
NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
G
Sos2
SOS Ras/Rho guanine nucleotide exchange factor 2
ISO IEA
KEGG RGD
PMID:16829981
rno:04012, RGD:2317988
NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692
G
Src
SRC proto-oncogene, non-receptor tyrosine kinase
IEP IEA ISO
KEGG PID RGD
PMID:15856020
PID:200101 rno:04012, RGD:1581134
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
G
Stat1
signal transducer and activator of transcription 1
ISO
PID
PID:200101
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
G
Stat3
signal transducer and activator of transcription 3
ISO
PID
PID:200101
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
G
Stat5a
signal transducer and activator of transcription 5A
IEA
KEGG
rno:04012
NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
G
Stat5b
signal transducer and activator of transcription 5B
IEA
KEGG
rno:04012
NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
G
Tgfa
transforming growth factor alpha
ISO IEA
KEGG PID RGD
PMID:15982853
PID:200159 rno:04012, RGD:2317963
NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
G
Tln1
talin 1
ISO
PID
PID:200101
NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900
G
Wasl
WASP like actin nucleation promoting factor
ISO
PID
PID:200101
NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:53,083,536...53,132,022
G
Egf
epidermal growth factor
ISO
RGD
PMID:19506583
RGD:5490965
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
G
Egfr
epidermal growth factor receptor
ISO
RGD
PMID:20519133 PMID:20951313 PMID:19506583
RGD:5133241 , RGD:5133242 , RGD:5490965
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
G
Erbb2
erb-b2 receptor tyrosine kinase 2
ISO
RGD
PMID:19078924 PMID:21277552
RGD:4143515 , RGD:5133243
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
G
Tgfa
transforming growth factor alpha
ISO
RGD
PMID:19506583
RGD:5490965
NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
Pathway Gene Annotations
Disease Annotations Associated with Genes in the epidermal growth factor/neuregulin signaling pathway
Abl1 acute lymphoblastic leukemia , Acute Lymphoblastic Leukemia, with Lymphomatous Features , acute myeloid leukemia , adenocarcinoma , Alzheimer's disease , autosomal recessive limb-girdle muscular dystrophy type 2K , B-lymphoblastic leukemia/lymphoma , bone development disease , Breast Neoplasms , Carcinogenesis , chronic myelogenous leukemia, BCR-ABL1 positive , chronic myeloid leukemia , citrullinemia , colorectal cancer , CONGENITAL HEART DEFECTS AND SKELETAL MALFORMATIONS SYNDROME , congenital heart disease , depressive disorder , Developmental Disease , Esophageal Neoplasms , esophagus adenocarcinoma , Experimental Neoplasms , Failure to Thrive , genetic disease , head and neck squamous cell carcinoma , hepatocellular carcinoma , Liver Neoplasms , lung non-small cell carcinoma , Memory Disorders , microcephaly , Musculoskeletal Abnormalities , Myeloid Leukemia, Chronic-Phase , Neurodevelopmental Disorders , Niemann-Pick disease , Niemann-Pick disease type C1 , oral squamous cell carcinoma , osteoporosis , Parkinson's disease , pre-malignant neoplasm , primary coenzyme Q10 deficiency 7 , stomach cancer , ureteral obstruction Abl2 1q24 Deletion Syndrome , chronic myeloid leukemia , gastrointestinal stromal tumor , genetic disease , parathyroid carcinoma Adam10 Alzheimer's disease , Alzheimer's disease 18 , Bloom syndrome , Breast Neoplasms , cardiomyopathy , cataract , Cognitive Dysfunction , colorectal cancer , Dowling-Degos disease , Experimental Arthritis , Fibrosis , Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis , genetic disease , IgA glomerulonephritis , kidney failure , Prenatal Exposure Delayed Effects , reticulate acropigmentation of Kitamura , status epilepticus , thoracic aortic aneurysm , traumatic brain injury , ureteral obstruction Adam12 distal 10q deletion syndrome , genetic disease , osteoarthritis , ureteral obstruction Adam17 Alzheimer's disease , atopic dermatitis , Blister , Brain Hypoxia , colitis , congestive heart failure , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Colitis , Experimental Liver Cirrhosis , genetic disease , Kidney Reperfusion Injury , Left Ventricular Hypertrophy , Neonatal Inflammatory Skin and Bowel Disease 1 , Pneumococcal Meningitis , renal fibrosis , syndromic microphthalmia 5 , thoracic aortic aneurysm , type 2 diabetes mellitus , ureteral obstruction Adam19 congenital heart disease , genetic disease , lung adenocarcinoma , squamous cell carcinoma , ureteral obstruction Adam9 Alzheimer's disease , cervix uteri carcinoma in situ , chronic obstructive pulmonary disease , cone-rod dystrophy , cone-rod dystrophy 3 , cone-rod dystrophy 9 , COVID-19 , genetic disease , hereditary spastic paraplegia 54 , hypogonadotropic hypogonadism 2 with or without anosmia , pancreatic cancer , pancreatic ductal carcinoma , paraplegia , Prostatic Neoplasms , retinitis pigmentosa , status epilepticus , Uterine Cervical Neoplasms Akt1 Acute Lung Injury , acute promyelocytic leukemia , adenocarcinoma , Alzheimer's disease , amphetamine abuse , amyotrophic lateral sclerosis , Animal Disease Models , atherosclerosis , autosomal recessive polycystic kidney disease , bipolar disorder , bone osteosarcoma , Brain Injuries , brain ischemia , breast adenocarcinoma , breast cancer , Breast Cancer, Familial , Breast Neoplasms , Calcification of Aortic Valve , cannabis abuse , Carcinogenesis , cardiac arrest , Cardiomegaly , cardiomyopathy , Charcot-Marie-Tooth disease axonal type 2O , chronic myeloid leukemia , colon cancer , colon carcinoma , colorectal cancer , Colorectal Neoplasms , coronary artery disease , Cowden syndrome 6 , Diabetic Cardiomyopathies , diabetic retinopathy , Endometrioid Carcinomas , Endotoxemia , epilepsy , esophageal cancer , esophagus squamous cell carcinoma , Experimental Arthritis , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , familial adenomatous polyposis , Fibrosis , focal segmental glomerulosclerosis 5 , gastric adenocarcinoma , genetic disease , glioblastoma , head and neck squamous cell carcinoma , hepatocellular carcinoma , Hepatomegaly , Hereditary Neoplastic Syndromes , Hyperplasia , hypertension , Hypertriglyceridemia , idiopathic pulmonary fibrosis , impotence , in situ carcinoma , Inflammation , intermediate coronary syndrome , Intervertebral Disc Displacement , invasive ductal carcinoma , Kidney Neoplasms , lung adenocarcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung oat cell carcinoma , lung small cell carcinoma , lung squamous cell carcinoma , Macrocephaly Mesodermal Hamartoma Spectrum , malignant astrocytoma , melanoma , Memory Disorders , Meningeal Neoplasms , meningioma , muscular atrophy , myocardial infarction , Myocardial Reperfusion Injury , Neointima , obesity , osteosarcoma , ovarian cancer , Ovarian Neoplasms , Pain , pancreatic cancer , pancreatic intraductal papillary-mucinous neoplasm , paraplegia , Parkinson's disease , pre-malignant neoplasm , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , Proteus syndrome , pulmonary tuberculosis , renal cell carcinoma , Reperfusion Injury , Right Ventricular Hypertrophy , schizophrenia , skin melanoma , Skin Neoplasms , Spinal Cord Injuries , squamous cell carcinoma , Staphylococcal Pneumonia , steatotic liver disease , Stroke , substance-induced psychosis , T-cell non-Hodgkin lymphoma , Thyroid Neoplasms , transitional cell carcinoma , type 2 diabetes mellitus , ureteral obstruction , urinary bladder cancer , Uterine Cervical Neoplasms , Ventilator-Induced Lung Injury , vulva cancer Akt2 adenocarcinoma , Breast Neoplasms , Carpenter Syndrome 2 , colorectal cancer , Colorectal Neoplasms , congenital hypoplastic anemia , craniosynostosis , Diamond-Blackfan anemia , endometrial cancer , Experimental Mammary Neoplasms , familial partial lipodystrophy , genetic disease , hepatocellular carcinoma , high grade glioma , hypertension , hypoglycemia , hypoinsulinemic hypoglycemia with hemihypertrophy , Insulin Resistance , ischemia , lung non-small cell carcinoma , malignant astrocytoma , maple syrup urine disease , maturity-onset diabetes of the young type 1 , Myocardial Reperfusion Injury , Neonatal Hypoglycemia, Simulating Foetopathia Diabetica , Neoplasm Metastasis , obesity , ovarian carcinoma , Ovarian Neoplasms , pancreatic cancer , polycystic ovary syndrome , prostate adenocarcinoma , prostate cancer , prostate carcinoma , Prostatic Neoplasms , Thyroid Neoplasms , type 2 diabetes mellitus Akt3 Bardet-Biedl syndrome , Bardet-Biedl syndrome 16 , capillary hemangioma , colon cancer , complex cortical dysplasia with other brain malformations , COVID-19 , developmental and epileptic encephalopathy 54 , Developmental Disabilities , gastrointestinal stromal tumor , genetic disease , glioblastoma , lung non-small cell carcinoma , Macrocephaly , malignant astrocytoma , megacolon , Megalencephaly - Cutis Marmorata Telangiectatica Congenita , Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome , Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2 , Neurodevelopmental Disorders , pancreatic adenocarcinoma , parathyroid carcinoma , polymicrogyria , prostate adenocarcinoma , prostate cancer , renal cell carcinoma , Senior-Loken syndrome , Senior-Loken Syndrome 7 Areg Animal Mammary Neoplasms , asthma , breast cancer , Breast Neoplasms , COVID-19 , ductal carcinoma in situ , Endometrioid Carcinomas , endometriosis , erythropoietic protoporphyria , Experimental Mammary Neoplasms , genetic disease , Head and Neck Neoplasms , high grade glioma , invasive ductal carcinoma , juvenile rheumatoid arthritis , lung non-small cell carcinoma , Myocardial Ischemia , Ovarian Neoplasms , prostate carcinoma in situ , Prostatic Neoplasms , psoriasis , pulmonary fibrosis , squamous cell carcinoma , Stomach Neoplasms , transitional cell carcinoma , urinary bladder cancer Bad acute kidney failure , Alzheimer's disease , amyotrophic lateral sclerosis , Brain Injuries , brain ischemia , breast cancer , Burns , Cardiomegaly , Chemical and Drug Induced Liver Injury , Chronic Pancreatitis , colon cancer , Diabetic Cardiomyopathies , Diabetic Cystopathy , diabetic neuropathy , endometrial cancer , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , gastric ulcer , genetic disease , glaucoma , Hemorrhagic Shock , high grade glioma , hypertension , hypothyroidism , impotence , Insulin Resistance , intellectual disability , intermittent claudication , leukemia , leukocyte adhesion deficiency 3 , Liver Reperfusion Injury , lung non-small cell carcinoma , macular degeneration , middle cerebral artery infarction , Myocardial Reperfusion Injury , obesity , osteoarthritis , pancreatic cancer , Parkinsonism , prostate carcinoma , prostatic hypertrophy , Prostatic Neoplasms , pulmonary fibrosis , renal cell carcinoma , Reperfusion Injury , Retina Reperfusion Injury , Sepsis , Small-For-Size Syndrome , Spinal Cord Reperfusion Injury , transient cerebral ischemia , traumatic brain injury , type 2 diabetes mellitus , visual epilepsy Braf adrenocortical carcinoma , ameloblastoma , Aortic Aneurysm, Giant Congenital , arteriovenous malformations of the brain , ataxia telangiectasia , B-Cell Chronic Lymphocytic Leukemia , bile duct adenoma , Brain Neoplasms , Breast Neoplasms , cancer , Carcinogenesis , cardiofaciocutaneous syndrome , cardiofaciocutaneous syndrome 1 , cardiomyopathy , cholangiocarcinoma , chronic lymphocytic leukemia , chronic myelogenous leukemia, BCR-ABL1 positive , chronic myeloid leukemia , colon carcinoma , Colonic Neoplasms , colorectal adenocarcinoma , colorectal cancer , Colorectal Neoplasms , Costello syndrome , craniopharyngioma , Dandy-Walker syndrome , Developmental Disabilities , diffuse large B-cell lymphoma , dilated cardiomyopathy , disease of cellular proliferation , dysembryoplastic neuroepithelial tumor , dysplastic nevus syndrome , endometrial carcinoma , Experimental Melanoma , Experimental Neoplasms , familial melanoma , Follicular Thyroid Cancer , gallbladder cancer , ganglioglioma , gastric adenocarcinoma , gastrointestinal stromal tumor , genetic disease , germinoma , glioblastoma , head and neck squamous cell carcinoma , hepatocellular carcinoma , high grade glioma , hypertrophic cardiomyopathy , hypertrophic cardiomyopathy 4 , intellectual disability , intrahepatic cholangiocarcinoma , Kidney Neoplasms , Langerhans-cell histiocytosis , Liver Metastasis , Liver Neoplasms , lung adenocarcinoma , lung cancer , lung carcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung squamous cell carcinoma , lymphangioma , Lymphatic Metastasis , malignant astrocytoma , Mandibular Neoplasms , melanoma , Microsatellite Instability , multiple myeloma , myoepithelioma , Neoplasm Metastasis , nephroblastoma , neuroendocrine tumor , Nevus , newborn respiratory distress syndrome , non-Hodgkin lymphoma , Nonseminomatous Germ Cell Tumor , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome 7 , Noonan syndrome with multiple lentigines , Noonan syndrome with multiple lentigines 3 , Ovarian Neoplasms , ovarian serous cystadenocarcinoma , pancreatic acinar cell adenocarcinoma , pancreatic cancer , papillary renal cell carcinoma , Paraproteinemias , PHACE Association , plasma cell neoplasm , pleomorphic xanthoastrocytoma , Premature Birth , primary cutaneous T-cell non-Hodgkin lymphoma , prostate adenocarcinoma , Prostate Cancer, Hereditary, 1 , Prostatic Neoplasms , pulmonary valve stenosis , RASopathy , Sezary's disease , skin melanoma , Sporadic Papillary Renal Cell Carcinoma , tethered spinal cord syndrome , thyroid gland papillary carcinoma , Thyroid Neoplasms , transitional cell carcinoma , type 2 diabetes mellitus , uterine cancer , Vascular Malformations , ventricular septal defect Btc erythropoietic protoporphyria , Experimental Diabetes Mellitus , genetic disease , Glucagonoma , insulinoma , otitis media , type 1 diabetes mellitus , type 2 diabetes mellitus Camk2a Alzheimer's disease , autism spectrum disorder , autosomal dominant intellectual developmental disorder 53 , autosomal recessive intellectual developmental disorder 63 , bipolar disorder , Cocaine-Related Disorders , Developmental Disabilities , familial adenomatous polyposis 1 , genetic disease , Hearing Loss, Cisplatin-Induced , Hepatomegaly , Hereditary Neoplastic Syndromes , high grade glioma , Hyperalgesia , Inflammation , intellectual disability , Larsen syndrome , middle cerebral artery infarction , mitochondrial metabolism disease , nephrotoxicity , Neurodevelopmental Disorders , transient cerebral ischemia , Wilson disease Camk2b Apnea , autism spectrum disorder , autosomal dominant intellectual developmental disorder 54 , cannabis abuse , Cocaine-Related Disorders , Developmental Disabilities , Developmental Disease , dystonia , genetic disease , Hearing Loss, Cisplatin-Induced , high grade glioma , Hyperventilation , intellectual disability , microcephaly , Nervous System Malformations , Neurodevelopmental Disorders , oligodendroglioma , phencyclidine abuse , pleomorphic xanthoastrocytoma , schizophrenia , substance-induced psychosis Camk2d aniridia , atrial fibrillation , Cardiomegaly , epilepsy , Experimental Liver Cirrhosis , genetic disease , myocardial infarction , Myocardial Ischemia , Neurodevelopmental Disorders , polycystic ovary syndrome , renovascular hypertension Camk2g autistic disorder , Autosomal Dominant Intellectual Developmental Disorder 59 , genetic disease , intellectual disability , malignant astrocytoma , Neurodevelopmental Disorders Cbl acute myeloid leukemia , B-Cell Chronic Lymphocytic Leukemia , B-lymphoblastic leukemia/lymphoma with hyperdiploidy , Carotid Artery Injuries , CD3epsilon deficiency , Chromosome 11, Partial Trisomy 11q , colorectal cancer , congenital diaphragmatic hernia , congenital disorder of glycosylation Ij , congenital myasthenic syndrome 13 , congestive heart failure , cryptorchidism , Developmental Disabilities , Dilated Cardiomyopathy with Left Ventricular Noncompaction , Dwarfism , Experimental Arthritis , Experimental Leukemia , genetic disease , Growth Disorders , hematologic cancer , Hematologic Neoplasms , hepatocellular carcinoma , hyperglycemia , immunodeficiency 17 , immunodeficiency 18 , immunodeficiency 19 , inflammatory bowel disease 28 , isolated microphthalmia 5 , juvenile myelomonocytic leukemia , long QT syndrome 10 , lung non-small cell carcinoma , Lymphatic Metastasis , lymphopenia , male infertility , malignant ovarian germ cell neoplasm , microcephaly , multiple myeloma , myeloid neoplasm , Myocardial Reperfusion Injury , Neurodevelopmental Disorders , Noonan Like Syndrome , Noonan syndrome , Noonan syndrome 1 , Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic Leukemia , osteosarcoma , ovarian germ cell cancer , Peripheral Nerve Injuries , RASopathy , rhabdomyosarcoma , schizophrenia , Stroke , transient cerebral ischemia , type 1 diabetes mellitus , vasculitis Cblb Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , genetic disease , Insulin Resistance , lung metastasis , lung non-small cell carcinoma , lung squamous cell carcinoma , Lymphatic Metastasis , multiple sclerosis , Multisystem Autoimmune Disease, Infantile-Onset, 3 , Peripheral Nerve Injuries , Radiation Pneumonitis , stomach carcinoma , type 1 diabetes mellitus Cblc genetic disease Cdkn1a acoustic neuroma , Acute Experimental Pancreatitis , Animal Mammary Neoplasms , Arsenic Poisoning , atrial fibrillation , autosomal dominant polycystic kidney disease , Barrett's esophagus , Bowen's Disease , Brain Injuries , Breast Neoplasms , carcinoma , cervix uteri carcinoma in situ , cholesteatoma of middle ear , chronic obstructive pulmonary disease , Colonic Neoplasms , Congenital Cholesteatoma , Diabetic Nephropathies , ductal carcinoma in situ , Embryo Loss , Endometrial Neoplasms , Esophageal Neoplasms , esophagus squamous cell carcinoma , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , facioscapulohumeral muscular dystrophy , Fuchs' endothelial dystrophy , genetic disease , growth hormone secreting pituitary adenoma , Habitual Abortions , Hearing Loss, Noise-Induced , hepatocellular carcinoma , high grade glioma , human immunodeficiency virus infectious disease , Hyperoxia , Hyperplasia , Hypertrophy , Hypovolemia , Intestinal Neoplasms , inverted papilloma , kidney disease , laryngeal squamous cell carcinoma , Lip Neoplasms , lipoid nephrosis , liver benign neoplasm , Liver Neoplasms , localized scleroderma , Lung Neoplasms , lung non-small cell carcinoma , Lymphatic Metastasis , macular degeneration , malignant mesothelioma , maxillary sinus squamous cell carcinoma , melanoma , Neoplasm Metastasis , ocular hypertension , Oral Lichen Planus , oral mucosa leukoplakia , oral squamous cell carcinoma , Ovarian Neoplasms , pancreatic carcinoma , pancreatic ductal carcinoma , papilloma , Phyllodes Tumor , Pituitary Neoplasms , pre-malignant neoplasm , Premature Aging , primary biliary cholangitis , primary open angle glaucoma , prostate cancer , Prostatic Neoplasms , proteasome-associated autoinflammatory syndrome 1 , psoriasis , pulmonary hypertension , renal hypertension , Reperfusion Injury , retinal degeneration , RETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIES , Salivary Gland Neoplasms , sarcoidosis , Sarcopenia , sebaceous gland neoplasm , Sepsis , serous cystadenocarcinoma , Skin Neoplasms , squamous cell carcinoma , stomach carcinoma , Stomach Neoplasms , systemic lupus erythematosus , T-cell non-Hodgkin lymphoma , Thyroid Neoplasms , Tongue Neoplasms , tongue squamous cell carcinoma , transitional cell carcinoma , ulcerative colitis , urinary bladder cancer , Uterine Cervical Neoplasms Cdkn1b acute kidney failure , acute myeloid leukemia , autosomal dominant intellectual developmental disorder 6 , Brain Injuries , breast cancer , Breast Neoplasms , cataract , cervix uteri carcinoma in situ , Chloracne , chronic myeloid leukemia , Diabetic Nephropathies , Endometrial Neoplasms , Endometrioid Carcinomas , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Fallopian Tube Neoplasms , Familial Prostate Cancer , Fibrosis , genetic disease , glaucoma , Helicobacter Infections , hepatocellular adenoma , hepatocellular carcinoma , Hereditary Neoplastic Syndromes , hyperthyroidism , infertility , influenza , Intestinal Neoplasms , Kidney Neoplasms , Left Ventricular Hypertrophy , Leukoencephalopathies , Leydig cell tumor , Liver Neoplasms , lung cancer , Lung Neoplasms , lung non-small cell carcinoma , lung small cell carcinoma , Lymphatic Metastasis , macular degeneration , membranoproliferative glomerulonephritis , membranous glomerulonephritis , Mesothelioma , multiple endocrine neoplasia , multiple endocrine neoplasia type 4 , myelodysplastic syndrome , myocardial infarction , nephroblastoma , neuroendocrine tumor , obesity , ovarian cancer , Ovarian Neoplasms , paraganglioma , pheochromocytoma , pituitary adenoma , Pituitary Neoplasms , primary hyperparathyroidism , prostate carcinoma in situ , Prostatic Neoplasms , pulmonary hypertension , rectal benign neoplasm , renal cell carcinoma , Reperfusion Injury , sciatic neuropathy , senile cataract , Sezary's disease , Spinal Cord Injuries , Stomach Neoplasms , Testicular Neoplasms , transitional cell carcinoma , urinary bladder cancer , Uterine Cervical Neoplasms , Uterine Neoplasms Crk chromosome 17p13.3 duplication syndrome , degenerative disc disease , genetic disease , Myocardial Ischemia Crkl autistic disorder , Breast Neoplasms , chromosome 22q11.2 deletion syndrome, distal , chromosome 22q11.2 microduplication syndrome , chronic myeloid leukemia , colon carcinoma , DiGeorge syndrome , epilepsy , genetic disease , intellectual disability , invasive ductal carcinoma , lung carcinoma , megacolon , Neurodevelopmental Disorders , ovarian cancer , primary immunodeficiency disease , prostate carcinoma , schizophrenia , skin cancer , velocardiofacial syndrome Egf acute kidney failure , adenocarcinoma , AIDS-Associated Nephropathy , Alzheimer's disease , autistic disorder , Breast Neoplasms , cholangiocarcinoma , cleft palate , dermatitis , Diabetic Nephropathies , Disease Progression , endometrial cancer , Endometrial Neoplasms , Experimental Liver Cirrhosis , gallbladder cancer , gastric ulcer , genetic disease , Genetic Predisposition to Disease , glioblastoma , Helicobacter Infections , hepatocellular carcinoma , hereditary renal cell carcinoma , high grade glioma , inclusion body myopathy with Paget disease of bone and frontotemporal dementia , juvenile rheumatoid arthritis , kidney disease , lung adenocarcinoma , lung non-small cell carcinoma , lupus nephritis , Metaplasia , Neoplasm Invasiveness , Neoplasm Metastasis , Neoplastic Cell Transformation , oligodendroglioma , ovarian cancer , pancreatic cancer , pancreatic ductal carcinoma , pancreatitis , Parkinson's disease , perinatal necrotizing enterocolitis , pneumonia , pre-malignant neoplasm , primary hypomagnesemia , Prostatic Neoplasms , pulmonary fibrosis , renal hypomagnesemia 3 , renal hypomagnesemia 4 , renal hypomagnesemia 5 with ocular involvement , Reperfusion Injury , schizophrenia , shigellosis , Tympanic Membrane Perforation , Wounds and Injuries , Zollinger-Ellison syndrome Egfr acute kidney failure , Acute Lung Injury , adenocarcinoma , adrenocortical carcinoma , Alcoholic Liver Diseases , Alzheimer's disease , Animal Mammary Neoplasms , aortic valve disease , aortic valve stenosis , arteriovenous malformations of the brain , asthma , autistic disorder , autosomal recessive polycystic kidney disease , Bannayan-Riley-Ruvalcaba syndrome , Bile Duct Neoplasms , Brain Neoplasms , breast cancer , breast carcinoma , Breast Neoplasms , bronchiolo-alveolar adenocarcinoma , carcinoma , Cardiomegaly , cerebral palsy , Chloracne , cholangiocarcinoma , chronic obstructive pulmonary disease , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , Coronavirus infectious disease , Craniofacial Abnormalities , dementia , dermatitis , diabetes mellitus , diabetic retinopathy , dilated cardiomyopathy , Disease Progression , endometrial carcinoma , Endometrioid Carcinomas , endometriosis , esophageal carcinoma , Esophageal Neoplasms , esophagus squamous cell carcinoma , Experimental Arthritis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , familial adenomatous polyposis , Gallbladder Neoplasms , genetic disease , glioblastoma , head and neck cancer , Head and Neck Neoplasms , head and neck squamous cell carcinoma , Helicobacter Infections , hepatocellular carcinoma , hereditary breast ovarian cancer syndrome , Hereditary Neoplastic Syndromes , high grade glioma , Huntington's disease , Hyperplasia , hypertension , Immediate Hypersensitivity , Inflammation , Insulin Resistance , Laryngeal Neoplasms , laryngeal squamous cell carcinoma , Left Ventricular Hypertrophy , leiomyoma , liver cirrhosis , lung adenocarcinoma , lung cancer , lung carcinoma , lung disease , Lung Neoplasms , lung non-small cell carcinoma , lung small cell carcinoma , lung squamous cell carcinoma , Lymphatic Metastasis , malignant mesothelioma , median neuropathy , Mesothelioma , Nasopharyngeal Neoplasms , Neonatal Inflammatory Skin and Bowel Disease 2 , Neoplasm Invasiveness , Neoplasm Metastasis , Neoplasm Recurrence, Local , obesity , oral squamous cell carcinoma , osteosarcoma , ovarian cancer , Ovarian Neoplasms , pancreatic cancer , papilloma , papillomavirus infectious disease , Parkinson's disease , Parkinsonism , peptic esophagitis , Phyllodes Tumor , pleomorphic xanthoastrocytoma , prostate cancer , Prostatic Neoplasms , pulmonary fibrosis , pulmonary hypertension , Pulmonary Hypertension, Hypoxia-Induced , pulmonary tuberculosis , rectal benign neoplasm , renal cell carcinoma , Right Ventricular Hypertrophy , schizophrenia , severe acute respiratory syndrome , Spinal Cord Injuries , squamous cell carcinoma , stomach cancer , Stomach Neoplasms , Tobacco Use Disorder , tongue squamous cell carcinoma , transitional cell carcinoma , type 1 diabetes mellitus , type 2 diabetes mellitus , urinary bladder cancer , Uterine Cervical Neoplasms , Vascular Remodeling , Ventricular Fibrillation Eif4ebp1 acute myeloid leukemia , genetic disease , hereditary spastic paraplegia 54 , human immunodeficiency virus infectious disease , hypogonadotropic hypogonadism 2 with or without anosmia , Inflammation , Kidney Neoplasms , lung non-small cell carcinoma , mantle cell lymphoma , Myocardial Ischemia , paraplegia , pre-malignant neoplasm , tuberous sclerosis Elk1 Alzheimer's disease , anxiety disorder , autistic disorder , Brain Injuries , congenital disorder of glycosylation type IIm , Fetal Growth Retardation , genetic disease , Huntington's disease , immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome , Lewy body dementia , neurodegeneration with brain iron accumulation 5 , schizophrenia , syndromic X-linked intellectual disability Lubs type , transient cerebral ischemia , X-linked epilepsy with variable learning disabilities and behavior disorders , X-linked severe congenital neutropenia Erbb2 adenocarcinoma , amblyopia , Animal Disease Models , Animal Mammary Neoplasms , basal cell carcinoma , Breast Cancer, Familial , Breast Neoplasms , calcinosis , Carcinogenesis , cholangiocarcinoma , Circulating Neoplastic Cells , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , congestive heart failure , Diabetic Cardiomyopathies , dilated cardiomyopathy , disease of cellular proliferation , Disease Progression , ductal carcinoma in situ , Endometrial Neoplasms , Endometrioid Carcinomas , esophageal carcinoma , Esophageal Neoplasms , Experimental Mammary Neoplasms , Experimental Neoplasms , Familial Visceral Neuropathy 2, Autosomal Recessive , gallbladder carcinoma , Gallbladder Neoplasms , gastric adenocarcinoma , Gastrointestinal Neoplasms , genetic disease , Germ Cell and Embryonal Neoplasms , head and neck squamous cell carcinoma , Helicobacter Infections , HELLP syndrome , high grade glioma , Hirschsprung's disease , hypertrophic cardiomyopathy 25 , interstitial cystitis , invasive ductal carcinoma , invasive lobular carcinoma , Kidney Neoplasms , laryngeal squamous cell carcinoma , lung adenocarcinoma , lung cancer , Lung Neoplasms , lung non-small cell carcinoma , Lymphatic Metastasis , mammary Paget's disease , median neuropathy , medulloblastoma , melanoma , Mouth Neoplasms , myelodysplastic syndrome , myocardial infarction , Myocardial Ischemia , Neoplasm Metastasis , Neoplasm Recurrence, Local , nephroblastoma , oral squamous cell carcinoma , ovarian cancer , ovarian carcinoma , Ovarian Neoplasms , ovarian serous cystadenocarcinoma , ovary adenocarcinoma , pancreatic adenocarcinoma , papillary renal cell carcinoma , papilloma , Parkinson's disease , pre-eclampsia , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , Recurrence , renal cell carcinoma , skin melanoma , Sporadic Papillary Renal Cell Carcinoma , stomach cancer , stomach carcinoma , Stomach Neoplasms , transitional cell carcinoma , urinary bladder cancer , Urologic Neoplasms , uterine cancer , uterine carcinosarcoma , Uterine Cervical Neoplasms , Ventilator-Induced Lung Injury , Wallerian Degeneration Erbb3 amblyopia , Breast Neoplasms , chronic obstructive pulmonary disease , Colonic Neoplasms , colorectal adenocarcinoma , Colorectal Neoplasms , disease of cellular proliferation , Disease Progression , ductal carcinoma in situ , Endometrial Neoplasms , Endometrioid Carcinomas , Experimental Mammary Neoplasms , Familial Erythroleukemia , Familial Visceral Neuropathy , gallbladder carcinoma , Gallbladder Neoplasms , gastric adenocarcinoma , genetic disease , hepatocellular carcinoma , intestinal pseudo-obstruction , laryngeal squamous cell carcinoma , lethal congenital contracture syndrome 2 , lung adenocarcinoma , Lung Neoplasms , lung non-small cell carcinoma , Lymphatic Metastasis , median neuropathy , Mouth Neoplasms , nasopharynx carcinoma , Neoplasm Metastasis , neuronal intestinal dysplasia type A , Ovarian Neoplasms , Phyllodes Tumor , prostate cancer , Prostatic Neoplasms , Recurrence , Spinal Cord Injuries , stomach carcinoma , Stomach Neoplasms , tongue squamous cell carcinoma , transitional cell carcinoma , urinary bladder cancer , Urinary Bladder Neoplasm , uterine cancer , uterine carcinosarcoma , Uterine Cervical Neoplasms , Wallerian Degeneration Erbb4 amblyopia , amyotrophic lateral sclerosis , amyotrophic lateral sclerosis type 10 , amyotrophic lateral sclerosis type 19 , atrial fibrillation , Breast Neoplasms , cervical cancer , colorectal cancer , congestive heart failure , Diabetic Cardiomyopathies , ductal carcinoma in situ , Endometrial Neoplasms , Endometrioid Carcinomas , epilepsy , esophagus squamous cell carcinoma , Experimental Mammary Neoplasms , frontotemporal dementia , Gallbladder Neoplasms , genetic disease , head and neck squamous cell carcinoma , hepatocellular carcinoma , Hyperalgesia , interstitial cystitis , laryngeal squamous cell carcinoma , lung adenocarcinoma , Lymphatic Metastasis , median neuropathy , melanoma , myocardial infarction , NATURAL KILLER CELL ENTEROPATHY , Neointima , Neoplasm Metastasis , Neurodevelopmental Disorders , oral squamous cell carcinoma , Ovarian Neoplasms , peripheral nervous system disease , Phyllodes Tumor , prostate cancer , radiculopathy , renal cell carcinoma , schizophrenia , Skin Neoplasms , stomach carcinoma , Stroke , Subarachnoid Hemorrhage , teratoma , tongue squamous cell carcinoma , transitional cell carcinoma , trichorhinophalangeal syndrome type I , urinary bladder cancer , Uterine Cervical Neoplasms , visual epilepsy Ereg cholesteatoma , erythropoietic protoporphyria , Experimental Colitis , extrapulmonary tuberculosis , genetic disease , hepatocellular carcinoma , Ovarian Neoplasms , pulmonary tuberculosis , tuberculosis Gab1 autosomal recessive nonsyndromic deafness 26 , Experimental Liver Cirrhosis , genetic disease , Helicobacter Infections , polycystic ovary syndrome , sensorineural hearing loss Gnai1 amnestic disorder , Developmental Disease , epilepsy , genetic disease , NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, IMPAIRED SPEECH, AND BEHAVIORAL ABNORMALITIES , Neurodevelopmental Disorders , pleomorphic xanthoastrocytoma , withdrawal disorder Gnai3 amnestic disorder , Auriculocondylar Syndrome , Auriculocondylar Syndrome 1 , autistic disorder , genetic disease , hereditary spastic paraplegia 63 , hypertension , Reperfusion Injury Gper1 Breast Neoplasms , COVID-19 , Dysbiosis , endometriosis , generalized anxiety disorder , genetic disease , Hepatomegaly , Hyperalgesia , idiopathic pulmonary fibrosis , leiomyoma , Liver Neoplasms , melanoma , Multiple Abnormalities , Spinal Cord Injuries Grb2 breast cancer , endometrial carcinoma , genetic disease , prostate adenocarcinoma , prostate cancer Gsk3b Aberrant Crypt Foci , acute kidney failure , acute myocardial infarction , Alzheimer's disease , amyotrophic lateral sclerosis , bipolar disorder , Brain Injuries , Breast Neoplasms , Burns , Cardiomegaly , cognitive disorder , colon cancer , Colonic Neoplasms , colorectal adenocarcinoma , congestive heart failure , degenerative disc disease , depressive disorder , diabetic encephalopathy , Diabetic Nephropathies , dilated cardiomyopathy , Drug-Induced Dyskinesia , endometrial carcinoma , Endometrial Neoplasms , Experimental Arthritis , Experimental Mammary Neoplasms , genetic disease , Hearing Loss, Cisplatin-Induced , heart disease , hypertension , Intestinal Neoplasms , Liver Reperfusion Injury , mantle cell lymphoma , middle cerebral artery infarction , Multiple Abnormalities , muscular atrophy , myocardial infarction , Myocardial Reperfusion Injury , Neoplastic Cell Transformation , neuronal ceroid lipofuscinosis 6A , oral squamous cell carcinoma , Ovarian Neoplasms , Parkinson's disease , peritonitis , Poisoning , Prostatic Neoplasms , schizophrenia , sciatic neuropathy , Sepsis , status epilepticus , Subarachnoid Hemorrhage , substance-related disorder , Tachycardia , tauopathy , type 2 diabetes mellitus , urinary bladder cancer , vascular dementia Gsn Acute Coronary Syndrome , Acute Liver Failure , amyloidosis , Aortic Calcification , Arterial Thrombosis , atrial fibrillation , Basal Ganglia Hemorrhage , Brain Hypoxia-Ischemia , Brain Injuries , Cardiomegaly , cerebral infarction , Chemical and Drug Induced Liver Injury , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , Familial Amyloidosis , Finnish type amyloidosis , gas gangrene , genetic disease , hypothyroidism , lung disease , Mesothelioma , Metabolic Syndrome , middle cerebral artery infarction , myocardial infarction , osteoporosis , Paratuberculosis , Postoperative Atrial Fibrillation , pre-eclampsia , Preterm Intraventricular Hemorrhage , pulmonary artery disease , rheumatic myocarditis , Sepsis , Subarachnoid Hemorrhage , Thromboembolism , Ventricular Remodeling , Weight Gain Hbegf acute kidney failure , Animal Disease Models , autosomal dominant intellectual developmental disorder 31 , Cardiotoxicity , end stage renal disease , endometriosis , epilepsy with generalized tonic-clonic seizures , familial adenomatous polyposis 1 , genetic disease , glomerulosclerosis , Hereditary Neoplastic Syndromes , juvenile rheumatoid arthritis , Left Ventricular Hypertrophy , Neurodevelopmental Disorders , perinatal necrotizing enterocolitis , Reperfusion Injury , Stomach Neoplasms Hras acute myeloid leukemia , adenoid cystic carcinoma , Alzheimer's disease , angiosarcoma , Animal Mammary Neoplasms , autistic disorder , autoimmune hepatitis , B-Cell Chronic Lymphocytic Leukemia , bladder carcinoma , Brain Neoplasms , Breast Neoplasms , carcinoma , cardiofaciocutaneous syndrome , Chanarin-Dorfman syndrome , chronic lymphocytic leukemia , Colorectal Neoplasms , complex cortical dysplasia with other brain malformations , congenital fibrosis of the extraocular muscles , Congenital Myopathy with Excess of Muscle Spindles , Costello syndrome , delta beta-thalassemia , developmental and epileptic encephalopathy , diabetic retinopathy , disease of cellular proliferation , Disease Progression , early infantile epileptic encephalopathy , endometrial carcinoma , epidermal nevus , esophageal carcinoma , Experimental Diabetes Mellitus , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Experimental Neoplasms , Follicular Thyroid Cancer , gastric adenocarcinoma , genetic disease , glioblastoma , head and neck squamous cell carcinoma , hepatocellular adenoma , hepatocellular carcinoma , Hereditary Neoplastic Syndromes , high grade glioma , Hydrops Fetalis , Hypophosphatemic Rickets , immunodeficiency 39 , intellectual disability , large congenital melanocytic nevus , Leber congenital amaurosis , linear nevus sebaceous syndrome , liver cancer , liver carcinoma , liver cirrhosis , Liver Neoplasms , lung adenocarcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung squamous cell carcinoma , melanoma , Mouth Neoplasms , multiple myeloma , myelodysplastic syndrome , Nasopharyngeal Neoplasms , Neoplasm Invasiveness , Neoplastic Cell Transformation , Neoplastic Processes , neuroblastoma , neuronal ceroid lipofuscinosis , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome 3 , obsessive-compulsive disorder , ovarian cancer , Ovarian Neoplasms , ovarian serous cystadenocarcinoma , pancreatic adenocarcinoma , papillary renal cell carcinoma , papilloma , Paraproteinemias , parathyroid adenoma , Penile Neoplasms , phobic disorder , Pigmented Nevus , plasma cell neoplasm , pre-malignant neoplasm , prostate adenocarcinoma , Prostate Cancer, Hereditary, 1 , Prostatic Neoplasms , pulmonary valve stenosis , RASopathy , Recurrence , rhabdomyosarcoma , Salivary Gland Neoplasms , Sebaceous Nevus Syndrome and Hemimegalencephaly , seminoma , skin benign neoplasm , skin melanoma , Skin Neoplasms , spermatocytoma , Splenic Neoplasms , Sporadic Papillary Renal Cell Carcinoma , squamous cell carcinoma , Stomach Neoplasms , T-cell non-Hodgkin lymphoma , thymoma , Thyroid Neoplasms , Tongue Neoplasms , transitional cell carcinoma , Trichilemmoma , urinary bladder cancer , Urinary Bladder Neoplasm , uterine cancer , uterine carcinosarcoma , Uterine Cervical Neoplasms Hsp90aa1 Alzheimer's disease , anaplastic large cell lymphoma , Breast Neoplasms , Charcot-Marie-Tooth disease axonal type 2O , Cognitive Dysfunction , colon cancer , contact dermatitis , Ductal Carcinoma , Experimental Diabetes Mellitus , Frontotemporal Lobar Degeneration , genetic disease , human immunodeficiency virus infectious disease , intrahepatic cholangiocarcinoma , Knee Osteoarthritis , Neoplasm Metastasis , Neurodevelopmental Disorders , portal hypertension , rheumatoid arthritis Jun Alcohol-Related Disorders , angiosarcoma , Asphyxia , Brain Injuries , brain ischemia , breast cancer , Breast Neoplasms , chronic obstructive pulmonary disease , Colonic Neoplasms , colorectal adenocarcinoma , colorectal adenoma , COVID-19 , depressive disorder , endometrial adenocarcinoma , endometrial carcinoma , extrahepatic cholestasis , genetic disease , glaucoma , Heat Stroke , hepatocellular carcinoma , Hodgkin's lymphoma , hypertension , Intestinal Polyps , juvenile rheumatoid arthritis , Liver Neoplasms , Lung Neoplasms , Mercury Poisoning, Nervous System , Nasal Polyps , Neoplastic Cell Transformation , Optic Nerve Injuries , oral squamous cell carcinoma , osteopetrosis , osteosarcoma , peripheral nervous system disease , prostate adenocarcinoma , prostate carcinoma , Prostatic Neoplasms , pulmonary emphysema , pulmonary tuberculosis , renal carcinoma , renal cell carcinoma , Reperfusion Injury , silicosis , Spinal Cord Injuries , status epilepticus , Stomach Neoplasms , tongue squamous cell carcinoma Kras Acute Experimental Pancreatitis , acute lymphoblastic leukemia , acute myeloid leukemia , adenocarcinoma , adenoid cystic carcinoma , adenoma , anaplastic astrocytoma , anemia , angiosarcoma , Animal Disease Models , arteriovenous malformations of the brain , autoimmune lymphoproliferative syndrome type 4 , B-Cell Chronic Lymphocytic Leukemia , breast adenocarcinoma , breast cancer , Breast Cancer, Familial , Breast Neoplasms , bronchiolo-alveolar adenocarcinoma , Capillary Malformation-Arteriovenous Malformation 1 , Carcinogenesis , carcinoma , cardiofaciocutaneous syndrome , cardiofaciocutaneous syndrome 1 , cardiofaciocutaneous syndrome 2 , cardiomyopathy , Cecal Neoplasms , cholangiocarcinoma , chronic lymphocytic leukemia , chronic myelogenous leukemia, BCR-ABL1 positive , chronic myeloid leukemia , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , Costello syndrome , dilated cardiomyopathy , disease of cellular proliferation , Disease Progression , Encephalocraniocutaneous Lipomatosis , endometrial adenocarcinoma , endometrial carcinoma , endometrial hyperplasia , Endometrial Hyperplasia without Atypia , Endometrial Intraepithelial Neoplasia , Endometrial Neoplasms , Endometrioid Carcinomas , endometriosis , epidermal nevus , esophageal carcinoma , Experimental Liver Neoplasms , Experimental Neoplasms , Experimental Sarcoma , fibrillary astrocytoma , gallbladder cancer , Gallbladder Neoplasms , gastric adenocarcinoma , gastrointestinal stromal tumor , genetic disease , glioblastoma , hepatocellular adenoma , hepatocellular carcinoma , hereditary breast ovarian cancer syndrome , hereditary diffuse gastric cancer , high grade glioma , Hodgkin's lymphoma , Hydrops Fetalis , hypertension , intellectual disability , intrahepatic cholangiocarcinoma , juvenile myelomonocytic leukemia , juvenile rheumatoid arthritis , Kidney Neoplasms , Klatskin's tumor , Leukocytosis , linear nevus sebaceous syndrome , Liver Neoplasms , lung adenocarcinoma , lung cancer , lung carcinoma , Lung Neoplasms , lung non-small cell carcinoma , Lung Reperfusion Injury , lung sarcomatoid carcinoma , lung squamous cell carcinoma , lymphoma , Lynch syndrome , malignant astrocytoma , melanoma , Mouth Neoplasms , Multiple Abnormalities , multiple myeloma , muscular atrophy , myelodysplastic syndrome , myeloid neoplasm , myeloid sarcoma , Neoplasm Metastasis , Neoplastic Cell Transformation , neuroblastoma , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome 3 , oculoectodermal syndrome , Ovarian Neoplasms , ovary serous adenocarcinoma , pancreatic adenocarcinoma , pancreatic cancer , pancreatic carcinoma , pancreatic ductal carcinoma , pancreatic mucinous cystadenoma , Paraproteinemias , Parasitic Liver Diseases , Penile Neoplasms , pilocytic astrocytoma , plasma cell neoplasm , prostate cancer , Prostate Cancer, Hereditary, 1 , prostate carcinoma in situ , Prostatic Neoplasms , RASopathy , Recurrence , renal cell carcinoma , renal fibrosis , Sebaceous Nevus Syndrome and Hemimegalencephaly , seminoma , skin melanoma , Splenomegaly , squamous cell carcinoma , stomach cancer , stomach carcinoma , Stomach Neoplasms , T-cell acute lymphoblastic leukemia , teratoma , Thyroid Carcinoma, Nonmedullary 1 , thyroid gland follicular carcinoma , thyroid gland medullary carcinoma , Thyroid Neoplasms , transitional cell carcinoma , Triple Negative Breast Neoplasms , urinary bladder cancer , Urinary Bladder Neoplasm , uterine cancer , Uterine Cervical Neoplasms , Uterine Neoplasms , Vascular Malformations Map2k1 autism spectrum disorder , Bloom syndrome , brain ischemia , breast cancer , cardiofaciocutaneous syndrome , cardiofaciocutaneous syndrome 3 , Cardiovascular Abnormalities , cataract , colorectal cancer , Colorectal Neoplasms , congestive heart failure , Costello syndrome , disease of cellular proliferation , Experimental Liver Neoplasms , Familial Prostate Cancer , gastric adenocarcinoma , genetic disease , hairy cell leukemia , head and neck squamous cell carcinoma , high grade glioma , lung adenocarcinoma , lung non-small cell carcinoma , lung squamous cell carcinoma , melanoma , melorheostosis , neuronal ceroid lipofuscinosis , non-Hodgkin lymphoma , Noonan syndrome , Noonan syndrome 1 , ovarian carcinoma , Ovarian Neoplasms , pancreatic adenocarcinoma , pancreatitis , prostate adenocarcinoma , Prostatic Neoplasms , RASopathy , renal cell carcinoma , skin melanoma , small intestine adenocarcinoma , Sturge-Weber syndrome , transitional cell carcinoma , uterine cancer , Vascular Malformations Map2k2 adenoid cystic carcinoma , amenorrhea , breast cancer , cardiofaciocutaneous syndrome , cardiofaciocutaneous syndrome 1 , cardiofaciocutaneous syndrome 4 , colorectal cancer , Costello syndrome , gastric adenocarcinoma , genetic disease , glioblastoma , head and neck squamous cell carcinoma , hepatocellular carcinoma , hypertrophic cardiomyopathy , lung non-small cell carcinoma , melanoma , Metabolic Syndrome , migraine , multicentric Castleman disease , neurofibromatosis-Noonan syndrome , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome with multiple lentigines , Ovarian Neoplasms , pancreatic adenocarcinoma , Prostatic Neoplasms , RASopathy , skin melanoma , small intestine adenocarcinoma , Smith-Magenis syndrome Map2k4 Brain Death , Breast Neoplasms , Cardiac Arrhythmias , chronic obstructive pulmonary disease , colorectal adenoma , colorectal cancer , gastric adenocarcinoma , genetic disease , hepatocellular carcinoma , invasive ductal carcinoma , laryngeal squamous cell carcinoma , lung adenocarcinoma , lung cancer , lung non-small cell carcinoma , nasopharynx carcinoma , Neoplasm Metastasis , neuroblastoma , Ovarian Neoplasms , ovarian serous carcinoma , pancreatic cancer , papilloma , prostate carcinoma in situ , Prostatic Neoplasms , Retina Reperfusion Injury , Skin Neoplasms , Sleep Deprivation , tongue squamous cell carcinoma , transient cerebral ischemia , urinary bladder cancer Map2k7 breast cancer , Breast Neoplasms , colon adenocarcinoma , colon cancer , congestive heart failure , esophageal carcinoma , Experimental Mammary Neoplasms , familial hemophagocytic lymphohistiocytosis 5 , Fibrosis , genetic disease , larynx cancer , Liver Metastasis , lung adenocarcinoma , lung carcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung squamous cell carcinoma , mucolipidosis type IV , neuroblastoma , Ovarian Neoplasms , pre-malignant neoplasm , prostate cancer , prostate carcinoma in situ , Prostatic Neoplasms , schizophrenia , stomach cancer , urinary bladder cancer Mapk1 Aberrant Crypt Foci , alcohol dependence , alcohol use disorder , Alzheimer's disease , Animal Disease Models , autism spectrum disorder , brain ischemia , breast cancer , Cardiomegaly , cardiomyopathy , childhood pilocytic astrocytoma , chromosome 22q11.2 deletion syndrome, distal , cocaine abuse , cocaine dependence , Cocaine-Related Disorders , colon adenocarcinoma , colon cancer , colorectal adenocarcinoma , Colorectal Neoplasms , congenital heart disease , coronary restenosis , Coronavirus infectious disease , demyelinating disease , depressive disorder , Diabetic Cardiomyopathies , Diabetic Nephropathies , DiGeorge syndrome , Dwarfism , endometrial adenocarcinoma , endometrial carcinoma , Endometrioid Carcinomas , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Experimental Radiation Injuries , extrahepatic cholestasis , Female Infertility , gastric ulcer , genetic disease , Gliosis , glomerulonephritis , Head and Neck Neoplasms , head and neck squamous cell carcinoma , Hemorrhagic Shock , hepatocellular carcinoma , Hodgkin's lymphoma , Hyperalgesia , Hypertrophy , intellectual disability , Intimal Hyperplasia , juvenile rheumatoid arthritis , kidney disease , Kidney Neoplasms , Left Ventricular Hypertrophy , Lung Neoplasms , melanoma , Memory Disorders , middle cerebral artery infarction , morphine dependence , Multiple Organ Failure , myocardial infarction , Myocardial Reperfusion Injury , Neoplasm Invasiveness , Neoplasm Metastasis , Nerve Degeneration , neuronal ceroid lipofuscinosis 6A , Noonan syndrome 13 , obesity , Ovarian Neoplasms , pancreatic adenocarcinoma , Parkinson's disease , Pneumococcal Pneumonia , portal hypertension , Postoperative Cognitive Dysfunction , prostate adenocarcinoma , pulmonary hypertension , renal cell carcinoma , renal fibrosis , Sepsis , severe acute respiratory syndrome , Sezary's disease , Shock , squamous cell carcinoma , Stomach Neoplasms , Testis Reperfusion Injury , thyroid cancer , Thyroid Neoplasms , transitional cell carcinoma , trigeminal neuralgia , type 2 diabetes mellitus , ureteral obstruction , urethral obstruction , Urinary Incontinence , Uterine Cervical Neoplasms , vascular dementia , velocardiofacial syndrome , Weissenbacher-Zweymuller syndrome , withdrawal disorder Mapk10 Alzheimer's disease , congestive heart failure , Generalized Epilepsy , genetic disease , Lennox-Gastaut syndrome , pancreatic adenocarcinoma , prostate cancer Mapk3 Aberrant Crypt Foci , alcohol dependence , alcohol use disorder , Alzheimer's disease , Animal Disease Models , Atrophy , autism spectrum disorder , autistic disorder , brain ischemia , cardiomyopathy , chromosome 16p11.2 deletion syndrome, 593-kb , chromosome 16p11.2 duplication syndrome , cocaine abuse , cocaine dependence , Cocaine-Related Disorders , colon adenocarcinoma , colorectal adenocarcinoma , Colorectal Neoplasms , Coronavirus infectious disease , coronin-1A deficiency , Developmental Disabilities , Diabetic Cardiomyopathies , endometrial adenocarcinoma , endometrial carcinoma , Endometrial Neoplasms , Endometrioid Carcinomas , episodic kinesigenic dyskinesia 1 , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Experimental Radiation Injuries , extrahepatic cholestasis , Female Infertility , gastric ulcer , genetic disease , Gliosis , Glycogen Storage Disease XII , Head and Neck Neoplasms , high grade glioma , Hyperalgesia , Hypertrophy , Insulin Resistance , Kidney Neoplasms , Lung Neoplasms , Memory Disorders , middle cerebral artery infarction , morphine dependence , Myocardial Reperfusion Injury , Neoplasm Invasiveness , Neoplasm Metastasis , Nerve Degeneration , Neurodevelopmental Disorders , neuronal ceroid lipofuscinosis 6A , obesity , Osteoarthritis, Experimental , Ovarian Neoplasms , pancreatic ductal carcinoma , Parkinson's disease , Pneumococcal Pneumonia , Postoperative Cognitive Dysfunction , Prostatic Neoplasms , pulmonary hypertension , schizophrenia , Sepsis , severe acute respiratory syndrome , Shock , spondylocostal dysostosis 5 , squamous cell carcinoma , Stomach Neoplasms , Testis Reperfusion Injury , trigeminal neuralgia , type 2 diabetes mellitus , ureteral obstruction , withdrawal disorder Mapk8 abdominal aortic aneurysm , Acute Liver Failure , Acute Otitis Media , alcohol use disorder , Alzheimer's disease , Animal Disease Models , anogenital venereal wart , anti-basement membrane glomerulonephritis , Arenaviridae infectious disease , atopic dermatitis , bacterial pneumonia , brain ischemia , candidiasis , Cardiomegaly , chronic mucocutaneous candidiasis , chronic obstructive pulmonary disease , Cockayne syndrome B , Colonic Neoplasms , colorectal adenocarcinoma , colorectal adenoma , Contrast-Induced Nephropathy , dengue disease , endometriosis , Endotoxemia , extrahepatic cholestasis , Helicobacter Infections , hepatitis , hepatocellular carcinoma , Hyperalgesia , hypertension , Infectious Ectromelia , influenza A , Intestinal Neoplasms , Kuhnt-Junius degeneration , Liver Reperfusion Injury , megacolon , metabolic dysfunction-associated steatotic liver disease , myocardial infarction , Myocardial Reperfusion Injury , Neoplastic Cell Transformation , Oxygen-Induced Retinopathy , pancreatic adenocarcinoma , pancreatic ductal adenocarcinoma , Parkinsonism , pre-malignant neoplasm , Pseudomonas Infections , rectal benign neoplasm , Reperfusion Injury , schizophrenia , Sepsis , steatotic liver disease , Stomach Neoplasms , Stroke , trigeminal neuralgia , type 2 diabetes mellitus Mapk9 Alzheimer's disease , Animal Disease Models , arteriosclerosis , colorectal cancer , extrahepatic cholestasis , genetic disease , hepatitis , Hyperalgesia , ischemia , Neoplasm Metastasis , pancreatic adenocarcinoma , pre-malignant neoplasm , Prostatic Neoplasms , Reperfusion Injury , trigeminal neuralgia , type 2 diabetes mellitus Mtor acute kidney failure , adenocarcinoma , AIDS-Associated Nephropathy , atherosclerosis , autism spectrum disorder , autosomal dominant nocturnal frontal lobe epilepsy , autosomal dominant polycystic kidney disease , autosomal recessive polycystic kidney disease , Breast Neoplasms , Burns , Cardiomegaly , CEBALID Syndrome , Cerebral Hemorrhage , Charcot-Marie-Tooth disease type 2 , chondrosarcoma , chromosome 1p36 deletion syndrome , Chronic Allograft Dysfunction , colon cancer , Colonic Neoplasms , Colorectal Neoplasms , complex cortical dysplasia with other brain malformations , congestive heart failure , crescentic glomerulonephritis , Diabetes Mellitus, New-Onset after Transplantation , Diabetic Cardiomyopathies , Diabetic Nephropathies , Drug-Induced Dyskinesia , end stage renal disease , endocrine system disease , epilepsy , exocrine pancreatic insufficiency , Experimental Arthritis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , Familial Atrial Fibrillation 6 , Focal Cortical Dysplasia of Taylor , gastric adenocarcinoma , genetic disease , glioblastoma , Hemimegalencephaly , Hemorrhagic Shock , hepatocellular carcinoma , Hepatomegaly , high grade glioma , Hyperalgesia , hypertension , Hypertriglyceridemia , idiopathic interstitial pneumonia , immunodeficiency 14 , Inflammation , intellectual disability , interstitial cystitis , kidney angiomyolipoma , Left Ventricular Hypertrophy , Lung Injury , Lung Neoplasms , lung non-small cell carcinoma , lung small cell carcinoma , lupus nephritis , Lymphatic Metastasis , Macrocephaly , mantle cell lymphoma , melanoma , Mesothelioma , middle cerebral artery infarction , muscular atrophy , Muscular Dystrophy, Animal , myocardial infarction , Neoplasm Metastasis , nephritis , Neurodevelopmental Disorders , obesity , osteoarthritis , Ovarian Neoplasms , pancreatic cancer , pancreatic carcinoma , papillary renal cell carcinoma , Parkinsonism , polycystic kidney disease , portal hypertension , prostate cancer , Prostatic Neoplasms , pulmonary fibrosis , pulmonary hypertension , renal carcinoma , renal cell carcinoma , Renal Cell Carcinoma 1 , Retinal Neovascularization , Right Ventricular Hypertrophy , schizophrenia , sciatic neuropathy , Sepsis , skin melanoma , small cell carcinoma , Smith-Kingsmore Syndrome , Spinal Cord Injuries , Sporadic Papillary Renal Cell Carcinoma , status epilepticus , T-cell acute lymphoblastic leukemia , temporal lobe epilepsy , Temporomandibular Joint Disorders , toxic encephalopathy , transient cerebral ischemia , transitional cell carcinoma , type 2 diabetes mellitus , ureteral obstruction , urinary bladder cancer , uterine cancer , Uterine Cervical Neoplasms , vascular dementia Myc Aberrant Crypt Foci , acute kidney failure , acute lymphoblastic leukemia , acute myeloid leukemia , acute promyelocytic leukemia , adenocarcinoma , Alcoholic Liver Diseases , angiosarcoma , Animal Disease Models , atherosclerosis , autosomal dominant polycystic kidney disease , autosomal recessive polycystic kidney disease , B-lymphoblastic leukemia/lymphoma , breast cancer , Breast Neoplasms , Burkitt lymphoma , carcinoma , Cardiomegaly , Carotid Artery Injuries , cholesteatoma of middle ear , Chromosome Breakage , chronic lymphocytic leukemia , clear cell renal cell carcinoma , cleft lip , cleft palate , Colonic Neoplasms , Colorectal Neoplasms , coronary restenosis , COVID-19 , demyelinating disease , diffuse large B-cell lymphoma , disease of cellular proliferation , Disease Progression , Ductal Carcinoma , Endometrial Neoplasms , esophageal carcinoma , Esophageal Neoplasms , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , genetic disease , glioblastoma , Hemorrhagic Shock , hepatitis C , hepatocellular carcinoma , Hodgkin's lymphoma , hyperparathyroidism , hypertrophic cardiomyopathy , Kidney Reperfusion Injury , Left Ventricular Hypertrophy , leiomyoma , liver cirrhosis , Liver Injury , Liver Neoplasms , lung adenocarcinoma , lung cancer , Lung Neoplasms , lung non-small cell carcinoma , Lung Reperfusion Injury , lung small cell carcinoma , medulloblastoma , Merkel cell carcinoma , myelodysplastic syndrome , Neoplasm Metastasis , Neoplastic Cell Transformation , nephroblastoma , neuroblastoma , neuroectodermal tumor , non-Hodgkin lymphoma , obesity , osteoporosis , osteosarcoma , Ovarian Neoplasms , pancreatic cancer , polycystic kidney disease , polycystic kidney disease 1 , primary ovarian insufficiency , prolactinoma , prostate adenocarcinoma , prostate cancer , prostate carcinoma in situ , prostatic hypertrophy , Prostatic Neoplasms , pulmonary hypertension , renal cell carcinoma , renal fibrosis , rhabdoid cancer , skin melanoma , Sporadic Papillary Renal Cell Carcinoma , squamous cell carcinoma , steatotic liver disease , Stomach Neoplasms , thyroid cancer , thyroid gland papillary carcinoma , Transplant Rejection , trichorhinophalangeal syndrome type I , urinary bladder cancer , Uterine Cervical Neoplasms Nck1 Albuminuria , genetic disease , nephrotic syndrome , Primary Lymphedema with Myelodysplasia , proteinuria Nck2 Albuminuria , Alzheimer's disease , genetic disease , nephrotic syndrome , proteinuria Nras acute lymphoblastic leukemia , acute myeloid leukemia , acute promyelocytic leukemia , adrenocortical carcinoma , adult T-cell leukemia/lymphoma , anemia , autoimmune lymphoproliferative syndrome , autoimmune lymphoproliferative syndrome type 4 , B-Cell Chronic Lymphocytic Leukemia , B-cell lymphoma , Brain Neoplasms , cervical cancer , cholangitis , chronic lymphocytic leukemia , chronic myelogenous leukemia, BCR-ABL1 positive , chronic myeloid leukemia , chronic myelomonocytic leukemia , colon carcinoma , colorectal cancer , Colorectal Neoplasms , disease of cellular proliferation , epidermal nevus , Experimental Arthritis , Experimental Leukemia , Experimental Liver Neoplasms , Experimental Neoplasms , Experimental Sarcoma , focal epilepsy , Follicular Thyroid Cancer , gastric adenocarcinoma , genetic disease , glioblastoma , hepatocellular carcinoma , hereditary spastic paraplegia 47 , juvenile myelomonocytic leukemia , large congenital melanocytic nevus , leukemia , Leukocytosis , linear nevus sebaceous syndrome , liver carcinoma , Liver Metastasis , lung adenocarcinoma , lung non-small cell carcinoma , lymphoma , medulloblastoma , melanoma , Mouth Neoplasms , multiple myeloma , myelodysplastic syndrome , myeloid leukemia associated with Down Syndrome , myeloid neoplasm , Nasopharyngeal Neoplasms , neuroblastoma , Neurocutaneous Melanosis , Neurodevelopmental Disorders , neurofibrosarcoma , non-Hodgkin lymphoma , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome 6 , ovarian serous cystadenocarcinoma , Paraproteinemias , Pigmented Nevus , plasma cell neoplasm , prostate cancer , Prostate Cancer, Hereditary, 1 , Pyogenic Granuloma , RASopathy , rectal benign neoplasm , renal cell carcinoma , Renal Cell Carcinoma 1 , Sebaceous Nevus Syndrome and Hemimegalencephaly , skin melanoma , Splenomegaly , Stomach Neoplasms , Thyroid Neoplasms , transitional cell carcinoma , uterine cancer Nrg1 alcohol use disorder , Alzheimer's disease , amblyopia , amphetamine abuse , amyotrophic lateral sclerosis , bipolar disorder , Breast Neoplasms , cannabis abuse , cannabis dependence , Cardiotoxicity , cerebral malaria , Charcot-Marie-Tooth disease , congestive heart failure , contact dermatitis , COVID-19 , dementia , Diabetic Cardiomyopathies , diabetic neuropathy , epilepsy , Experimental Liver Cirrhosis , Febrile Seizures , gastric ulcer , genetic disease , hepatocellular carcinoma , hereditary spastic paraplegia , Hirschsprung's disease , Hyperalgesia , influenza , interstitial cystitis , juvenile rheumatoid arthritis , Lung Neoplasms , major depressive disorder , median neuropathy , middle cerebral artery infarction , movement disease , myocardial infarction , Neointima , Neoplasm Invasiveness , Neoplastic Cell Transformation , Nerve Degeneration , obstructive sleep apnea , ovarian cancer , overactive bladder syndrome , Pain , polycystic ovary syndrome , psychotic disorder , schizophrenia , schizophrenia 6 , sciatic neuropathy , skin papilloma , Spinal Cord Injuries , stress-related disorder , Subarachnoid Hemorrhage , substance abuse , Tobacco Use Disorder , transient cerebral ischemia , tuberculosis , Viral Myocarditis , visual epilepsy Nrg2 autism spectrum disorder , autosomal dominant intellectual developmental disorder 31 , familial adenomatous polyposis 1 , genetic disease , Hereditary Neoplastic Syndromes , Neurodevelopmental Disorders Nrg3 genetic disease , Hirschsprung's disease , schizophrenia Nrg4 Bloom syndrome , colorectal cancer , genetic disease , schizophrenia Pak1 Acute Lung Injury , Alzheimer's disease , brain ischemia , breast cancer , Breast Neoplasms , Cardiac Fibrosis , Cardiomegaly , Experimental Neoplasms , genetic disease , Intellectual Developmental Disorder with Macrocephaly, Seizures, and Speech Delay , intellectual disability , Neointima , Neoplasm Invasiveness , nephroblastoma , NEURODEVELOPMENTAL DISORDER WITH BEHAVIORAL ABNORMALITIES, ABSENT SPEECH, AND HYPOTONIA , Neurodevelopmental Disorders , ovarian carcinoma , Ovarian Neoplasms , proteinuria , renal cell carcinoma , schizophrenia , Stroke , Thyroid Neoplasms , transitional cell carcinoma , Trauma and Stressor Related Disorders Pak2 atrial fibrillation , autism spectrum disorder , autistic disorder , Breast Neoplasms , chromosome 3q29 microdeletion syndrome , ductal carcinoma in situ , genetic disease , Knobloch Syndrome , Knobloch Syndrome Type II , proteinuria , Puromycin Aminonucleoside Nephrosis , schizophrenia , ureteral obstruction Pak3 autistic disorder , developmental and epileptic encephalopathy 36 , genetic disease , intellectual disability , microcephaly , non-syndromic X-linked intellectual disability , non-syndromic X-linked intellectual disability 30 , retinal degeneration , schizophrenia , syndromic X-linked intellectual disability Lubs type Pak4 clear cell renal cell carcinoma , Experimental Mammary Neoplasms , genetic disease , hereditary breast ovarian cancer syndrome , maturity-onset diabetes of the young type 1 , neuroblastoma , prostate cancer , retinal degeneration , type 2 diabetes mellitus Pak5 Alagille syndrome , ALAGILLE SYNDROME 1 , congenital myasthenic syndrome 18 , developmental and epileptic encephalopathy 12 , genetic disease Pak6 Bloom syndrome , clear cell renal cell carcinoma , colorectal cancer , genetic disease , keratoconus , mosaic variegated aneuploidy syndrome 1 , Prostatic Neoplasms Pdk1 genetic disease , split hand-foot malformation 5 Pik3ca adenocarcinoma , adenoid cystic carcinoma , adrenocortical carcinoma , Agenesis of Corpus Callosum , autosomal recessive polycystic kidney disease , Bannayan-Riley-Ruvalcaba syndrome , basal cell carcinoma , Brain Neoplasms , breast adenocarcinoma , breast angiosarcoma , breast cancer , Breast Cancer, Familial , breast carcinoma , Breast Neoplasms , Cardiovascular Abnormalities , Cerebral Cavernous Malformation 4 , CLAPO Syndrome , CLOVES syndrome , colon adenocarcinoma , colon carcinoma , colorectal cancer , colorectal carcinoma , Colorectal Neoplasms , complex cortical dysplasia with other brain malformations , Cowden syndrome , Cowden syndrome 5 , Currarino syndrome , cutaneous Paget's disease , Developmental Disabilities , Diabetic Cardiomyopathies , diaphragmatic eventration , diffuse large B-cell lymphoma , disease of cellular proliferation , Disease Progression , Down syndrome , endometrial carcinoma , Endometrial Neoplasms , epidermal nevus , esophageal cancer , esophageal carcinoma , esophagus adenocarcinoma , estrogen-receptor positive breast cancer , Facial Asymmetry , familial multiple nevi flammei , gallbladder cancer , gallbladder carcinoma , gastric adenocarcinoma , Gastrointestinal Neoplasms , genetic disease , glioblastoma , glycogen storage disease II , Growth Disorders , head and neck cancer , Head and Neck Neoplasms , head and neck squamous cell carcinoma , Hemimegalencephaly , hepatocellular carcinoma , Hereditary Neoplastic Syndromes , high grade glioma , Hyperplasia , Hypertelorism , keratoacanthoma , Klippel-Trenaunay syndrome , Leber congenital amaurosis , liver cancer , lung adenocarcinoma , lung cancer , lung carcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung oat cell carcinoma , lung small cell carcinoma , lung squamous cell carcinoma , Lymphatic Metastasis , Macrocephaly , medulloblastoma , Megalencephaly - Cutis Marmorata Telangiectatica Congenita , Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome , Megalodactyly , melanoma , Mouth Neoplasms , multiple myeloma , Nasopharyngeal Neoplasms , Neoplasm Metastasis , neuroblastoma , NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES , non-Hodgkin lymphoma , Noonan syndrome 8 , ovarian cancer , Ovarian Neoplasms , ovarian serous cystadenocarcinoma , pancreatic adenocarcinoma , papillary renal cell carcinoma , Paraproteinemias , Penile Neoplasms , plasma cell neoplasm , polycystic kidney disease , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , PTEN hamartoma tumor syndrome , rectal benign neoplasm , renal cell carcinoma , Renal Cell Carcinoma 1 , rosette-forming glioneuronal tumor , sarcoma , seborrheic keratosis , skin melanoma , Sporadic Papillary Renal Cell Carcinoma , squamous cell carcinoma , stomach cancer , Stomach Neoplasms , Stroke , Thyroid Neoplasms , transitional cell carcinoma , urinary bladder cancer , uterine cancer , uterine carcinosarcoma , Uterine Cervical Neoplasms , Vascular Malformations , Ventricular Dysfunction, Left , Weight Gain Pik3cb colorectal cancer , diffuse large B-cell lymphoma , endometrial cancer , Endometrial Neoplasms , genetic disease , glioblastoma , hepatocellular carcinoma , Lymphatic Metastasis , NATURAL KILLER CELL ENTEROPATHY , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , rectal benign neoplasm , schizophrenia , Subarachnoid Hemorrhage , thrombosis , type 2 diabetes mellitus Pik3cd Charcot-Marie-Tooth disease type 2 , Chlamydia pneumonia , chromosome 1p36 deletion syndrome , colorectal cancer , cutaneous leishmaniasis , diffuse large B-cell lymphoma , endometrial cancer , Experimental Arthritis , genetic disease , glioblastoma , immunodeficiency 14 , listeriosis , mantle cell lymphoma , Neurodevelopmental Disorders , primary immunodeficiency disease , Prostatic Neoplasms , Roifman-Chitayat Syndrome , schizophrenia , Streptococcus pneumonia , toxic shock syndrome , visceral leishmaniasis Pik3r1 agammaglobulinemia 7 , Alzheimer's disease , Animal Mammary Neoplasms , astroblastoma , Brain Neoplasms , Breast Neoplasms , Burkitt lymphoma , carcinoma , CLOVES syndrome , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , disease of cellular proliferation , endometrial adenocarcinoma , endometrial cancer , endometrial carcinoma , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , genetic disease , glioblastoma , glucose intolerance , hepatocellular carcinoma , hypertension , hypoglycemia , immunodeficiency 36 , Insulin Resistance , lung adenocarcinoma , lung small cell carcinoma , Megalencephaly - Cutis Marmorata Telangiectatica Congenita , melanoma , Nematode Infections , Neurodevelopmental Disorders , obesity , osteoarthritis , Ovarian Neoplasms , portal hypertension , primary immunodeficiency disease , prostate cancer , Prostatic Neoplasms , renal cell carcinoma , Reperfusion Injury , rheumatoid arthritis , Septic Peritonitis , SHORT syndrome , skin melanoma , Smith-Kingsmore Syndrome , type 2 diabetes mellitus , uterine cancer , uterine carcinosarcoma , Vascular Malformations , vitiligo , X-linked agammaglobulinemia Pik3r2 colon cancer , Colonic Neoplasms , Developmental Disabilities , Endometrioid Carcinomas , epilepsy , genetic disease , hepatocellular carcinoma , intellectual disability , Megalencephaly - Cutis Marmorata Telangiectatica Congenita , Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome , Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 , multiple myeloma , pancreatic ductal adenocarcinoma , prostate cancer , Prostatic Neoplasms , Smith-Kingsmore Syndrome Pik3r3 Breast Cancer, Familial , Charcot-Marie-Tooth disease dominant intermediate C , colon adenocarcinoma , Colorectal Neoplasms , developmental and epileptic encephalopathy , early infantile epileptic encephalopathy , genetic disease , hepatocellular carcinoma , high grade glioma , Neoplasm Metastasis Pik3r5 ataxia with oculomotor apraxia type 3 , colon cancer , genetic disease , spastic ataxia Pip5k1c genetic disease , lethal congenital contracture syndrome 3 , Neurodevelopmental Disorders Plcg1 acute myocardial infarction , adult T-cell leukemia/lymphoma , Alzheimer's disease , angiosarcoma , breast cancer , breast carcinoma , colon cancer , colorectal cancer , Experimental Diabetes Mellitus , familial adenomatous polyposis , focal epilepsy , genetic disease , hepatocellular carcinoma , hereditary breast ovarian cancer syndrome , IMMUNE DYSREGULATION, AUTOIMMUNITY, AND AUTOINFLAMMATION , laryngeal squamous cell carcinoma , lung adenocarcinoma , lung cancer , lung non-small cell carcinoma , oral squamous cell carcinoma , polycystic kidney disease , primary cutaneous T-cell non-Hodgkin lymphoma , Sezary's disease Plcg2 Alzheimer's disease , Autoinflammation, Antibody Deficiency, and Immune Dysregulation, PLCG2-Associated , B-Cell Chronic Lymphocytic Leukemia , Cryopyrin-Associated Periodic Syndromes , familial cold autoinflammatory syndrome , familial cold autoinflammatory syndrome 3 , Fever , genetic disease , inflammatory bowel disease Prkca brain ischemia , Breast Neoplasms , Cardiomegaly , chordoid glioma , congestive heart failure , dilated cardiomyopathy , ductal carcinoma in situ , endometrial carcinoma , Experimental Diabetes Mellitus , genetic disease , high grade glioma , hypertension , Intestinal Neoplasms , ischemia , large cell carcinoma , Left Ventricular Hypertrophy , metabolic dysfunction-associated steatotic liver disease , nephrogenic diabetes insipidus , occupational asthma , ovarian cancer , ovarian carcinoma , Pituitary Neoplasms , Polyuria , prostate carcinoma , Reperfusion Injury , Right Ventricular Hypertrophy , urinary bladder cancer Prkcb adult T-cell leukemia/lymphoma , Alzheimer's disease , autistic disorder , Cardiomegaly , Colorectal Neoplasms , congestive heart failure , Diabetic Nephropathies , dilated cardiomyopathy , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Fetal Diseases , genetic disease , Hyperalgesia , hyperglycemia , hypertension , immune system disease , Insulin Resistance , Left Ventricular Hypertrophy , lung non-small cell carcinoma , Myocardial Reperfusion Injury , obesity , sensorineural hearing loss , silicosis , status epilepticus , Stomach Neoplasms , type 2 diabetes mellitus Prkcg Animal Disease Models , autosomal dominant cerebellar ataxia , autosomal recessive spinocerebellar ataxia 14 , cerebellar ataxia , familial cold autoinflammatory syndrome 2 , genetic disease , hereditary ataxia , Hyperalgesia , intellectual disability , middle cerebral artery infarction , primary cerebellar degeneration , retinitis pigmentosa , Spinal Cord Injuries , spinocerebellar ataxia type 14 , Spinocerebellar Ataxias , trigeminal neuralgia Prkcz autism spectrum disorder , Cardiomegaly , chromosome 1p36 deletion syndrome , congenital myasthenic syndrome 8 , dilated cardiomyopathy 1LL , Ehlers-Danlos syndrome spondylodysplastic type 2 , genetic disease , Goldberg-Shprintzen syndrome , Hyperalgesia , hyperglycemia , idiopathic generalized epilepsy , immunodeficiency 16 , immunodeficiency 38 , Insulin Resistance , Joubert syndrome 25 , Left Ventricular Hypertrophy , leukemia , Neurodevelopmental Disorders , Peroxisome Biogenesis Disorder, Complementation Group 7 , Prostatic Neoplasms , Shprintzen-Goldberg Craniosynostosis , type 2 diabetes mellitus Ptk2 atrial fibrillation , autistic disorder , Breast Neoplasms , cervical cancer , cervix carcinoma , ductal carcinoma in situ , endometrial carcinoma , endometrial hyperplasia , endometriosis , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , genetic disease , glioblastoma , hepatocellular carcinoma , hypertension , ischemia , Left Ventricular Hypertrophy , leiomyoma , lung small cell carcinoma , lung squamous cell carcinoma , Lymphatic Metastasis , Mouth Neoplasms , Neoplasm Invasiveness , Neoplasm Metastasis , Neoplastic Cell Transformation , nephritis , ovarian carcinoma , prostate cancer , pulmonary hypertension , Reperfusion Injury , rheumatoid arthritis , Right Ventricular Hypertrophy , squamous cell carcinoma , uremia Ptpn1 B-cell lymphoma , Calcification of Aortic Valve , Carotid Artery Injuries , coronary artery disease , diabetes mellitus , essential hypertension , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , genetic disease , Hodgkin's lymphoma , hyperinsulinism , hypertension , Inflammation , Insulin Resistance , limb ischemia , Mediastinal Neoplasms , obesity , proliferative diabetic retinopathy , Rett syndrome , Stroke , type 2 diabetes mellitus , Wounds and Injuries Ptpn11 acute myeloid leukemia , acute promyelocytic leukemia , adenocarcinoma , anogenital venereal wart , aortic valve stenosis , arrhythmogenic right ventricular cardiomyopathy , atrial heart septal defect 1 , atrophic gastritis , autism spectrum disorder , B-Cell Chronic Lymphocytic Leukemia , Brain Neoplasms , Cafe-au-Lait Spots , cancer , cardiofaciocutaneous syndrome , cardiomyopathy , Cardiovascular Abnormalities , Carotid Artery Injuries , cervical cancer , chondroma , chronic lymphocytic leukemia , Colorectal Neoplasms , Costello syndrome , craniosynostosis , Developmental Disabilities , dilated cardiomyopathy , disease of metabolism , Duane retraction syndrome , Dwarfism , embryonal rhabdomyosarcoma , Experimental Leukemia , Failure to Thrive , Fetal Growth Retardation , Funnel Chest , gastric adenocarcinoma , genetic disease , glaucoma , Haemophilus Infections , Helicobacter Infections , hemorrhagic disease , hepatocellular adenoma , hereditary multiple exostoses , Hereditary Neoplastic Syndromes , high grade glioma , Hydrops Fetalis , hypertrophic cardiomyopathy , idiopathic scoliosis , influenza , intellectual disability , juvenile myelomonocytic leukemia , learning disability , leukemia , lung adenocarcinoma , lung squamous cell carcinoma , lymphoma , malignant astrocytoma , metachondromatosis , microcephaly , multiple myeloma , myeloid leukemia associated with Down Syndrome , neuroblastoma , Neurodevelopmental Disorders , neurofibroma , neurofibromatosis-Noonan syndrome , Noonan Like Syndrome , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome 3 , Noonan syndrome with multiple lentigines , Noonan syndrome with multiple lentigines 1 , Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic Leukemia , Ollier disease , Osteochondroma , Paraproteinemias , patent ductus arteriosus , patent foramen ovale , plasma cell neoplasm , ptosis , RASopathy , Right Ventricular Hypertrophy , scoliosis , squamous cell carcinoma , Staphylococcal Pneumonia , stomach cancer , strabismus , T-cell acute lymphoblastic leukemia , tetralogy of Fallot , thrombocytopenia , tricuspid valve insufficiency , Ventricular Premature Complexes , Ventricular Tachycardia , Werner syndrome Ptpn6 anogenital venereal wart , autism spectrum disorder , calcinosis , cervical cancer , developmental and epileptic encephalopathy 21 , genetic disease , heart valve disease , Hyperphosphatemic Familial Tumoral Calcinosis 1 , Klippel-Feil syndrome 3 , lymphoproliferative syndrome 2 , Neurodevelopmental Disorders , peroxisome biogenesis disorder 2B , respiratory allergy , Temtamy syndrome Ptprj colon carcinoma , colorectal cancer , Colorectal Neoplasms , genetic disease , hypertension , intellectual disability , lung adenocarcinoma , lung squamous cell carcinoma , Thrombocytopenia 10 Raf1 Breast Neoplasms , Cardiomegaly , colorectal adenocarcinoma , colorectal adenoma , Colorectal Neoplasms , dilated cardiomyopathy , dilated cardiomyopathy 1B , dilated cardiomyopathy 1NN , Dilated Cardiomyopathy with Left Ventricular Noncompaction , familial hypertrophic cardiomyopathy , gastric adenocarcinoma , genetic disease , high grade glioma , Hyperalgesia , hypertrophic cardiomyopathy , hypertrophic cardiomyopathy 1 , ischemia , Kidney Neoplasms , Liver Neoplasms , lung adenocarcinoma , Lung Neoplasms , lung non-small cell carcinoma , Lymphangiectasis , malignant mesothelioma , melanoma , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome 3 , Noonan syndrome 5 , Noonan syndrome with multiple lentigines , Noonan syndrome with multiple lentigines 2 , ovarian carcinoma , pancreatic adenocarcinoma , pancreatic carcinoma , Pituitary Stalk Interruption Syndrome , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , RASopathy , skin melanoma , Stroke , Ventricular Tachycardia Rasa1 Animal Mammary Neoplasms , arteriovenous malformation , basal cell carcinoma , Capillary Malformation-Arteriovenous Malformation , Capillary Malformation-Arteriovenous Malformation 1 , carcinoma , Central Nervous System Venous Angioma , Chemical and Drug Induced Liver Injury , Experimental Mammary Neoplasms , familial adenomatous polyposis 1 , genetic disease , hereditary hemorrhagic telangiectasia , Hereditary Neoplastic Syndromes , Infantile Capillary Hemangioma , Klippel-Trenaunay syndrome , Left Ventricular Hypertrophy , lung adenocarcinoma , Multiple Basal Cell Carcinoma , Neurodevelopmental Disorders , Port-Wine Stain , squamous cell carcinoma , Sturge-Weber syndrome , Vascular Malformations Rps6kb1 Atrophy , autosomal dominant polycystic kidney disease , Burns , Cardiomegaly , colon cancer , diffuse large B-cell lymphoma , dilated cardiomyopathy , genetic disease , hyperinsulinism , hypertension , Hypoproteinemia , Joubert syndrome 1 , Left Ventricular Hypertrophy , muscular atrophy , myocardial infarction , neuronal ceroid lipofuscinosis 1 , obesity , primary biliary cholangitis Rps6kb2 Aicardi-Goutieres Syndrome 3 , Breast Neoplasms , genetic disease , intellectual disability , Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations Shc1 Albuminuria , Alzheimer's disease , amyotrophic lateral sclerosis type 1 , Breast Neoplasms , Cardiomegaly , Charcot-Marie-Tooth disease type 2 , Chemical and Drug Induced Liver Injury , Chronic Hepatitis , familial hyperlipidemia , gastrointestinal stromal tumor , genetic disease , glomerulosclerosis , hepatocellular carcinoma , hyperglycemia , Hypertensive Nephropathy , immunodeficiency 42 , Insulin Resistance , Left Ventricular Hypertrophy , liver cirrhosis , MHC class II deficiency , parathyroid carcinoma , severe congenital neutropenia 3 , severe congenital neutropenia 5 , steatotic liver disease Shc2 genetic disease Shc3 Ependymomas , genetic disease Shc4 Bloom syndrome , colorectal cancer , genetic disease Sos1 arrhythmogenic right ventricular cardiomyopathy , atrial heart septal defect , Atrial Septal Defect, Secundum Type , brain ischemia , Brugada syndrome , Cafe au lait Spots, Multiple , cardiomyopathy , cerebral infarction , cervical cancer , congenital heart disease , dilated cardiomyopathy , Dwarfism , familial hypertrophic cardiomyopathy , genetic disease , gingival fibromatosis , Gingival Fibromatosis 1 , hypertrophic cardiomyopathy , hypertrophic cardiomyopathy 1 , intellectual disability , Joubert syndrome 3 , lung adenocarcinoma , Lynch syndrome , Muscle Hypotonia , Neurodevelopmental Disorders , Noonan Like Syndrome , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome 3 , Noonan syndrome 4 , Nuchal Bleb, Familial , prostate cancer , ptosis , pulmonary valve stenosis , RASopathy , Stroke , Sudden Unexpected Nocturnal Death Syndrome , uterine cancer , Ventricular Tachycardia Sos2 Brain-Lung-Thyroid Syndrome , Developmental Disease , genetic disease , L-2-hydroxyglutaric aciduria , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome 9 , RASopathy Src Aicardi-Goutieres Syndrome 5 , autosomal recessive polycystic kidney disease , brain ischemia , Breast Neoplasms , Cardiomegaly , colitis , colon adenocarcinoma , colon cancer , colon carcinoma , Colonic Neoplasms , colorectal cancer , colorectal carcinoma , Colorectal Neoplasms , disease of cellular proliferation , ductal carcinoma in situ , focal epilepsy , genetic disease , Hearing Loss, Noise-Induced , hepatocellular carcinoma , hypertension , Kidney Reperfusion Injury , Liver Metastasis , lung adenocarcinoma , lung metastasis , lung squamous cell carcinoma , Lymphatic Metastasis , myelofibrosis , nasopharynx carcinoma , Neoplasm Invasiveness , Neoplasm Metastasis , Neuralgia , pancreatic acinar cell adenocarcinoma , Parkinsonism , prostate cancer , Reperfusion Injury , sensorineural hearing loss , status epilepticus , stomach cancer , Stroke , Thrombocytopenia 6 , Trauma and Stressor Related Disorders , type 2 diabetes mellitus , urinary bladder cancer , Williams-Beuren syndrome Stat1 angiomyolipoma , Brain Injuries , breast cancer , breast carcinoma , chronic mucocutaneous candidiasis , colon adenocarcinoma , COVID-19 , Cytomegalovirus Infections , disease by infectious agent , Disease Progression , Dwarfism , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Failure to Thrive , gastric adenocarcinoma , genetic disease , Hearing Loss , hepatitis C , hepatocellular carcinoma , Human Influenza , immunodeficiency 31A , immunodeficiency 31B , immunodeficiency 31C , liver cirrhosis , lupus nephritis , lymphangioleiomyomatosis , lymphocytic choriomeningitis , Mycobacterium Infections , Myocardial Reperfusion Injury , Neoplasm Metastasis , nephroblastoma , Nervous System Trauma , Neurodevelopmental Disorders , Nontuberculous Mycobacterium Infections , pancreatic adenocarcinoma , periodontitis , primary immunodeficiency disease , prostate adenocarcinoma , pulmonary fibrosis , Reoviridae Infections , Reperfusion Injury , rheumatoid arthritis , scrapie , Sepsis , severe acute respiratory syndrome , T-cell acute lymphoblastic leukemia Stat3 acute myeloid leukemia , adenocarcinoma , adenoid cystic carcinoma , adult T-cell leukemia/lymphoma , Alzheimer's disease , anaplastic large cell lymphoma , angiomyolipoma , angiosarcoma , Animal Disease Models , Animal Mammary Neoplasms , atherosclerosis , Atrophy , autistic disorder , autoimmune disease , B-lymphoblastic leukemia/lymphoma , bacterial pneumonia , Behcet's disease , Brain Injuries , brain ischemia , breast cancer , Breast Neoplasms , carcinoma , Cardiomegaly , cardiomyopathy , cervix uteri carcinoma in situ , Choroidal Neovascularization , Chronic Hepatitis , Chronic Hepatitis C , chronic lymphocytic leukemia , Churg-Strauss syndrome , colon adenocarcinoma , colon cancer , Colonic Neoplasms , colorectal cancer , colorectal carcinoma , congenital diaphragmatic hernia , congestive heart failure , Copper-Overload Cirrhosis , Crohn's disease , depressive disorder , Diabetic Nephropathies , diffuse large B-cell lymphoma , duodenal ulcer , Endometrial Neoplasms , Epidermal Hyperplasia , esophageal carcinoma , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Uveitis , Experimental Autoimmune Uveoretinitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Experimental Neoplasms , Fever , Fibrosis , follicular dendritic cell sarcoma , gastric adenocarcinoma , genetic disease , glioblastoma , growth hormone insensitivity syndrome with immune dysregulation 1 , head and neck squamous cell carcinoma , heart disease , hepatocellular carcinoma , hyper IgE recurrent infection syndrome 1 , hyper IgE syndrome , Hyperalgesia , hyperuricemia , idiopathic pulmonary fibrosis , Inflammation , inflammatory bowel disease , irritant dermatitis , juvenile rheumatoid arthritis , liver cirrhosis , Liver Injury , Liver Neoplasms , lung non-small cell carcinoma , lymphangioleiomyomatosis , Lymphatic Metastasis , lymphoproliferative syndrome , medulloblastoma , Memory Disorders , metabolic dysfunction-associated steatotic liver disease , middle cerebral artery infarction , Multisystem Autoimmune Disease, Infantile-Onset, 1 , Myocardial Reperfusion Injury , Nasal Polyps , nasal type extranodal NK/T-cell lymphoma , nasopharynx carcinoma , Neoplasm Invasiveness , Neoplasm Metastasis , Neoplastic Cell Transformation , nephroblastoma , neutropenia , Niemann-Pick disease type C1 , obesity , ovarian cancer , Ovarian Neoplasms , Oxygen-Induced Retinopathy , pancreatic cancer , periodontitis , peripartum cardiomyopathy , pre-malignant neoplasm , primary immunodeficiency disease , prostate cancer , prostate carcinoma , Prostatic Neoplasms , psoriasis , psoriatic arthritis , pulmonary fibrosis , Pyogenic Granuloma , rectum adenocarcinoma , renal cell carcinoma , Reperfusion Injury , Retina Reperfusion Injury , rheumatoid arthritis , scrapie , Sepsis , Sepsis-Associated Encephalopathy , skin melanoma , Skin Neoplasms , squamous cell carcinoma , stomach cancer , Stomach Neoplasms , Subarachnoid Hemorrhage , T-cell acute lymphoblastic leukemia , T-cell non-Hodgkin lymphoma , Tongue Neoplasms , transient cerebral ischemia , type 1 diabetes mellitus , type 2 diabetes mellitus , ulcerative colitis , urinary bladder cancer , Uterine Cervical Neoplasms Stat5a Acute-Phase Reaction , adenocarcinoma , Animal Mammary Neoplasms , B-cell lymphoma , B-lymphoblastic leukemia/lymphoma , breast lobular carcinoma , Breast Neoplasms , carcinoma , castration-resistant prostate carcinoma , chronic myeloid leukemia , colon adenocarcinoma , Ductal Carcinoma , ductal carcinoma in situ , esophageal atresia , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , gastric adenocarcinoma , genetic disease , glioblastoma , growth hormone insensitivity syndrome with immune dysregulation 1 , hepatocellular carcinoma , hyper IgE recurrent infection syndrome 1 , invasive lobular carcinoma , Lung Neoplasms , Myocardial Ischemia , Neoplasm Metastasis , pre-malignant neoplasm , prostate cancer , Reperfusion Injury , Viral Bronchiolitis Stat5b Acute-Phase Reaction , colon adenocarcinoma , colorectal adenocarcinoma , Endotoxemia , Enteropathy-Associated T-Cell Lymphoma , Experimental Diabetes Mellitus , gastric adenocarcinoma , genetic disease , growth hormone insensitivity syndrome with immune dysregulation 1 , growth hormone insensitivity syndrome with immune dysregulation 2 , Growth Hormone Insensitivity with Immune Dysregulation , hepatocellular carcinoma , hyper IgE recurrent infection syndrome 1 , Hypoxia , Liver Neoplasms , lung non-small cell carcinoma , nasal type extranodal NK/T-cell lymphoma , primary cutaneous T-cell non-Hodgkin lymphoma , Prostatic Neoplasms , Reperfusion Injury , Splenomegaly , T-cell acute lymphoblastic leukemia , T-cell large granular lymphocyte leukemia , T-cell non-Hodgkin lymphoma , T-cell prolymphocytic leukemia , T-Lymphocytopenia Tgfa acute kidney failure , Animal Mammary Neoplasms , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , gallbladder carcinoma , gastroenteritis , genetic disease , Genetic Predisposition to Disease , Head and Neck Neoplasms , hepatoblastoma , hepatocellular carcinoma , Inflammation , insulinoma , Knee Osteoarthritis , Liver Neoplasms , Lung Injury , lung non-small cell carcinoma , mucositis , Nerve Degeneration , nonsyndromic deafness , pancreatic cancer , papilloma , Prostatic Neoplasms , psoriasis , pulmonary edema , pulmonary fibrosis , pulmonary hypertension , Right Ventricular Hypertrophy , Stomach Neoplasms , Stroke Tln1 acromesomelic dysplasia, Maroteaux type , anauxetic dysplasia , autosomal recessive distal hereditary motor neuronopathy 2 , capillary leak syndrome , cerebellar ataxia , distal arthrogryposis type 1A , frontotemporal dementia and/or amyotrophic lateral sclerosis 6 , galactosemia , genetic disease , hyperphosphatasia with impaired intellectual development syndrome 2 , Neoplasm Invasiveness , osteoporosis , primary ciliary dyskinesia Wasl atopic dermatitis , Chemical and Drug Induced Liver Injury , genetic disease , pleomorphic xanthoastrocytoma
1q24 Deletion Syndrome Abl2 abdominal aortic aneurysm Mapk8 Aberrant Crypt Foci Gsk3b , Mapk1 , Mapk3 , Myc acoustic neuroma Cdkn1a acromesomelic dysplasia, Maroteaux type Tln1 Acute Coronary Syndrome Gsn Acute Experimental Pancreatitis Cdkn1a , Kras acute kidney failure Bad , Cdkn1b , Egf , Egfr , Gsk3b , Hbegf , Mtor , Myc , Tgfa Acute Liver Failure Gsn , Mapk8 Acute Lung Injury Akt1 , Egfr , Pak1 acute lymphoblastic leukemia Abl1 , Kras , Myc , Nras Acute Lymphoblastic Leukemia, with Lymphomatous Features Abl1 acute myeloid leukemia Abl1 , Cbl , Cdkn1b , Eif4ebp1 , Hras , Kras , Myc , Nras , Ptpn11 , Stat3 acute myocardial infarction Gsk3b , Plcg1 Acute Otitis Media Mapk8 acute promyelocytic leukemia Akt1 , Myc , Nras , Ptpn11 Acute-Phase Reaction Stat5a , Stat5b adenocarcinoma Abl1 , Akt1 , Akt2 , Egf , Egfr , Erbb2 , Kras , Mtor , Myc , Pik3ca , Ptpn11 , Stat3 , Stat5a adenoid cystic carcinoma Hras , Kras , Map2k2 , Pik3ca , Stat3 adenoma Kras adrenocortical carcinoma Braf , Egfr , Nras , Pik3ca adult T-cell leukemia/lymphoma Nras , Plcg1 , Prkcb , Stat3 agammaglobulinemia 7 Pik3r1 Agenesis of Corpus Callosum Pik3ca Aicardi-Goutieres Syndrome 3 Rps6kb2 Aicardi-Goutieres Syndrome 5 Src AIDS-Associated Nephropathy Egf , Mtor Alagille syndrome Pak5 ALAGILLE SYNDROME 1 Pak5 Albuminuria Nck1 , Nck2 , Shc1 alcohol dependence Mapk1 , Mapk3 alcohol use disorder Mapk1 , Mapk3 , Mapk8 , Nrg1 Alcohol-Related Disorders Jun Alcoholic Liver Diseases Egfr , Myc Alzheimer's disease Abl1 , Adam10 , Adam17 , Adam9 , Akt1 , Bad , Camk2a , Egf , Egfr , Elk1 , Gsk3b , Hras , Hsp90aa1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nck2 , Nrg1 , Pak1 , Pik3r1 , Plcg1 , Plcg2 , Prkcb , Shc1 , Stat3 Alzheimer's disease 18 Adam10 amblyopia Erbb2 , Erbb3 , Erbb4 , Nrg1 ameloblastoma Braf amenorrhea Map2k2 amnestic disorder Gnai1 , Gnai3 amphetamine abuse Akt1 , Nrg1 amyloidosis Gsn amyotrophic lateral sclerosis Akt1 , Bad , Erbb4 , Gsk3b , Nrg1 amyotrophic lateral sclerosis type 1 Shc1 amyotrophic lateral sclerosis type 10 Erbb4 amyotrophic lateral sclerosis type 19 Erbb4 anaplastic astrocytoma Kras anaplastic large cell lymphoma Hsp90aa1 , Stat3 anauxetic dysplasia Tln1 anemia Kras , Nras angiomyolipoma Stat1 , Stat3 angiosarcoma Hras , Jun , Kras , Myc , Plcg1 , Stat3 Animal Disease Models Akt1 , Erbb2 , Hbegf , Kras , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Myc , Prkcg , Stat3 Animal Mammary Neoplasms Areg , Cdkn1a , Egfr , Erbb2 , Hras , Pik3r1 , Rasa1 , Stat3 , Stat5a , Tgfa aniridia Camk2d anogenital venereal wart Mapk8 , Ptpn11 , Ptpn6 anti-basement membrane glomerulonephritis Mapk8 anxiety disorder Elk1 Aortic Aneurysm, Giant Congenital Braf Aortic Calcification Gsn aortic valve disease Egfr aortic valve stenosis Egfr , Ptpn11 Apnea Camk2b Arenaviridae infectious disease Mapk8 arrhythmogenic right ventricular cardiomyopathy Ptpn11 , Sos1 Arsenic Poisoning Cdkn1a Arterial Thrombosis Gsn arteriosclerosis Mapk9 arteriovenous malformation Rasa1 arteriovenous malformations of the brain Braf , Egfr , Kras Asphyxia Jun asthma Areg , Egfr astroblastoma Pik3r1 ataxia telangiectasia Braf ataxia with oculomotor apraxia type 3 Pik3r5 atherosclerosis Akt1 , Mtor , Myc , Stat3 atopic dermatitis Adam17 , Mapk8 , Wasl atrial fibrillation Camk2d , Cdkn1a , Erbb4 , Gsn , Pak2 , Ptk2 atrial heart septal defect Sos1 atrial heart septal defect 1 Ptpn11 Atrial Septal Defect, Secundum Type Sos1 atrophic gastritis Ptpn11 Atrophy Mapk3 , Rps6kb1 , Stat3 Auriculocondylar Syndrome Gnai3 Auriculocondylar Syndrome 1 Gnai3 autism spectrum disorder Camk2a , Camk2b , Map2k1 , Mapk1 , Mapk3 , Mtor , Nrg2 , Pak2 , Prkcz , Ptpn11 , Ptpn6 autistic disorder Camk2g , Crkl , Egf , Egfr , Elk1 , Gnai3 , Hras , Mapk3 , Pak2 , Pak3 , Prkcb , Ptk2 , Stat3 autoimmune disease Stat3 autoimmune hepatitis Hras autoimmune lymphoproliferative syndrome Nras autoimmune lymphoproliferative syndrome type 4 Kras , Nras Autoinflammation, Antibody Deficiency, and Immune Dysregulation, PLCG2-Associated Plcg2 autosomal dominant cerebellar ataxia Prkcg autosomal dominant intellectual developmental disorder 31 Hbegf , Nrg2 autosomal dominant intellectual developmental disorder 53 Camk2a autosomal dominant intellectual developmental disorder 54 Camk2b Autosomal Dominant Intellectual Developmental Disorder 59 Camk2g autosomal dominant intellectual developmental disorder 6 Cdkn1b autosomal dominant nocturnal frontal lobe epilepsy Mtor autosomal dominant polycystic kidney disease Cdkn1a , Mtor , Myc , Rps6kb1 autosomal recessive distal hereditary motor neuronopathy 2 Tln1 autosomal recessive intellectual developmental disorder 63 Camk2a autosomal recessive limb-girdle muscular dystrophy type 2K Abl1 autosomal recessive nonsyndromic deafness 26 Gab1 autosomal recessive polycystic kidney disease Akt1 , Egfr , Mtor , Myc , Pik3ca , Src autosomal recessive spinocerebellar ataxia 14 Prkcg B-Cell Chronic Lymphocytic Leukemia Braf , Cbl , Hras , Kras , Nras , Plcg2 , Ptpn11 B-cell lymphoma Nras , Ptpn1 , Stat5a B-lymphoblastic leukemia/lymphoma Abl1 , Myc , Stat3 , Stat5a B-lymphoblastic leukemia/lymphoma with hyperdiploidy Cbl bacterial pneumonia Mapk8 , Stat3 Bannayan-Riley-Ruvalcaba syndrome Egfr , Pik3ca Bardet-Biedl syndrome Akt3 Bardet-Biedl syndrome 16 Akt3 Barrett's esophagus Cdkn1a basal cell carcinoma Erbb2 , Pik3ca , Rasa1 Basal Ganglia Hemorrhage Gsn Behcet's disease Stat3 bile duct adenoma Braf Bile Duct Neoplasms Egfr bipolar disorder Akt1 , Camk2a , Gsk3b , Nrg1 bladder carcinoma Hras Blister Adam17 Bloom syndrome Adam10 , Map2k1 , Nrg4 , Pak6 , Shc4 bone development disease Abl1 bone osteosarcoma Akt1 Bowen's Disease Cdkn1a Brain Death Map2k4 Brain Hypoxia Adam17 Brain Hypoxia-Ischemia Gsn Brain Injuries Akt1 , Bad , Cdkn1a , Cdkn1b , Elk1 , Gsk3b , Gsn , Jun , Stat1 , Stat3 brain ischemia Akt1 , Bad , Jun , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Pak1 , Prkca , Sos1 , Src , Stat3 Brain Neoplasms Braf , Egfr , Hras , Nras , Pik3ca , Pik3r1 , Ptpn11 Brain-Lung-Thyroid Syndrome Sos2 breast adenocarcinoma Akt1 , Kras , Pik3ca breast angiosarcoma Pik3ca breast cancer Akt1 , Areg , Bad , Cdkn1b , Egfr , Grb2 , Jun , Kras , Map2k1 , Map2k2 , Map2k7 , Mapk1 , Myc , Pak1 , Pik3ca , Plcg1 , Stat1 , Stat3 Breast Cancer, Familial Akt1 , Erbb2 , Kras , Pik3ca , Pik3r3 breast carcinoma Egfr , Pik3ca , Plcg1 , Stat1 breast lobular carcinoma Stat5a Breast Neoplasms Abl1 , Adam10 , Akt1 , Akt2 , Areg , Braf , Cdkn1a , Cdkn1b , Crkl , Egf , Egfr , Erbb2 , Erbb3 , Erbb4 , Gper1 , Gsk3b , Hras , Hsp90aa1 , Jun , Kras , Map2k4 , Map2k7 , Mtor , Myc , Nrg1 , Pak1 , Pak2 , Pik3ca , Pik3r1 , Prkca , Ptk2 , Raf1 , Rps6kb2 , Shc1 , Src , Stat3 , Stat5a bronchiolo-alveolar adenocarcinoma Egfr , Kras Brugada syndrome Sos1 Burkitt lymphoma Myc , Pik3r1 Burns Bad , Gsk3b , Mtor , Rps6kb1 Cafe au lait Spots, Multiple Sos1 Cafe-au-Lait Spots Ptpn11 Calcification of Aortic Valve Akt1 , Ptpn1 calcinosis Erbb2 , Ptpn6 cancer Braf , Ptpn11 candidiasis Mapk8 cannabis abuse Akt1 , Camk2b , Nrg1 cannabis dependence Nrg1 capillary hemangioma Akt3 capillary leak syndrome Tln1 Capillary Malformation-Arteriovenous Malformation Rasa1 Capillary Malformation-Arteriovenous Malformation 1 Kras , Rasa1 Carcinogenesis Abl1 , Akt1 , Braf , Erbb2 , Kras carcinoma Cdkn1a , Egfr , Hras , Kras , Myc , Pik3r1 , Rasa1 , Stat3 , Stat5a cardiac arrest Akt1 Cardiac Arrhythmias Map2k4 Cardiac Fibrosis Pak1 cardiofaciocutaneous syndrome Braf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11 cardiofaciocutaneous syndrome 1 Braf , Kras , Map2k2 cardiofaciocutaneous syndrome 2 Kras cardiofaciocutaneous syndrome 3 Map2k1 cardiofaciocutaneous syndrome 4 Map2k2 Cardiomegaly Akt1 , Bad , Camk2d , Egfr , Gsk3b , Gsn , Mapk1 , Mapk8 , Mtor , Myc , Pak1 , Prkca , Prkcb , Prkcz , Raf1 , Rps6kb1 , Shc1 , Src , Stat3 cardiomyopathy Adam10 , Akt1 , Braf , Kras , Mapk1 , Mapk3 , Ptpn11 , Sos1 , Stat3 Cardiotoxicity Hbegf , Nrg1 Cardiovascular Abnormalities Map2k1 , Pik3ca , Ptpn11 Carotid Artery Injuries Cbl , Myc , Ptpn1 , Ptpn11 Carpenter Syndrome 2 Akt2 castration-resistant prostate carcinoma Stat5a cataract Adam10 , Cdkn1b , Map2k1 CD3epsilon deficiency Cbl CEBALID Syndrome Mtor Cecal Neoplasms Kras Central Nervous System Venous Angioma Rasa1 cerebellar ataxia Prkcg , Tln1 Cerebral Cavernous Malformation 4 Pik3ca Cerebral Hemorrhage Mtor cerebral infarction Gsn , Sos1 cerebral malaria Nrg1 cerebral palsy Egfr cervical cancer Erbb4 , Nras , Ptk2 , Ptpn11 , Ptpn6 , Sos1 cervix carcinoma Ptk2 cervix uteri carcinoma in situ Adam9 , Cdkn1a , Cdkn1b , Stat3 Chanarin-Dorfman syndrome Hras Charcot-Marie-Tooth disease Nrg1 Charcot-Marie-Tooth disease axonal type 2O Akt1 , Hsp90aa1 Charcot-Marie-Tooth disease dominant intermediate C Pik3r3 Charcot-Marie-Tooth disease type 2 Mtor , Pik3cd , Shc1 Chemical and Drug Induced Liver Injury Bad , Gsn , Rasa1 , Shc1 , Wasl childhood pilocytic astrocytoma Mapk1 Chlamydia pneumonia Pik3cd Chloracne Cdkn1b , Egfr cholangiocarcinoma Braf , Egf , Egfr , Erbb2 , Kras cholangitis Nras cholesteatoma Ereg cholesteatoma of middle ear Cdkn1a , Myc chondroma Ptpn11 chondrosarcoma Mtor chordoid glioma Prkca Choroidal Neovascularization Stat3 Chromosome 11, Partial Trisomy 11q Cbl chromosome 16p11.2 deletion syndrome, 593-kb Mapk3 chromosome 16p11.2 duplication syndrome Mapk3 chromosome 17p13.3 duplication syndrome Crk chromosome 1p36 deletion syndrome Mtor , Pik3cd , Prkcz chromosome 22q11.2 deletion syndrome, distal Crkl , Mapk1 chromosome 22q11.2 microduplication syndrome Crkl chromosome 3q29 microdeletion syndrome Pak2 Chromosome Breakage Myc Chronic Allograft Dysfunction Mtor Chronic Hepatitis Shc1 , Stat3 Chronic Hepatitis C Stat3 chronic lymphocytic leukemia Braf , Hras , Kras , Myc , Nras , Ptpn11 , Stat3 chronic mucocutaneous candidiasis Mapk8 , Stat1 chronic myelogenous leukemia, BCR-ABL1 positive Abl1 , Braf , Kras , Nras chronic myeloid leukemia Abl1 , Abl2 , Akt1 , Braf , Cdkn1b , Crkl , Kras , Nras , Stat5a chronic myelomonocytic leukemia Nras chronic obstructive pulmonary disease Adam9 , Cdkn1a , Egfr , Erbb3 , Jun , Map2k4 , Mapk8 Chronic Pancreatitis Bad Churg-Strauss syndrome Stat3 Circulating Neoplastic Cells Erbb2 citrullinemia Abl1 CLAPO Syndrome Pik3ca clear cell renal cell carcinoma Myc , Pak4 , Pak6 cleft lip Myc cleft palate Egf , Myc CLOVES syndrome Pik3ca , Pik3r1 cocaine abuse Mapk1 , Mapk3 cocaine dependence Mapk1 , Mapk3 Cocaine-Related Disorders Camk2a , Camk2b , Mapk1 , Mapk3 Cockayne syndrome B Mapk8 cognitive disorder Gsk3b Cognitive Dysfunction Adam10 , Hsp90aa1 colitis Adam17 , Src colon adenocarcinoma Map2k7 , Mapk1 , Mapk3 , Pik3ca , Pik3r3 , Src , Stat1 , Stat3 , Stat5a , Stat5b colon cancer Akt1 , Akt3 , Bad , Gsk3b , Hsp90aa1 , Map2k7 , Mapk1 , Mtor , Pik3r2 , Pik3r5 , Plcg1 , Rps6kb1 , Src , Stat3 colon carcinoma Akt1 , Braf , Crkl , Nras , Pik3ca , Ptprj , Src Colonic Neoplasms Braf , Cdkn1a , Egfr , Erbb2 , Erbb3 , Gsk3b , Jun , Kras , Mapk8 , Mtor , Myc , Pik3r1 , Pik3r2 , Src , Stat3 colorectal adenocarcinoma Braf , Erbb3 , Gsk3b , Jun , Mapk1 , Mapk3 , Mapk8 , Raf1 , Stat5b colorectal adenoma Jun , Map2k4 , Mapk8 , Raf1 colorectal cancer Abl1 , Adam10 , Akt1 , Akt2 , Braf , Cbl , Egfr , Erbb2 , Erbb4 , Kras , Map2k1 , Map2k2 , Map2k4 , Mapk9 , Nras , Nrg4 , Pak6 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Plcg1 , Ptprj , Shc4 , Src , Stat3 colorectal carcinoma Pik3ca , Src , Stat3 Colorectal Neoplasms Akt1 , Akt2 , Braf , Egfr , Erbb2 , Erbb3 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Mtor , Myc , Nras , Pik3ca , Pik3r1 , Pik3r3 , Prkcb , Ptpn11 , Ptprj , Raf1 , Src complex cortical dysplasia with other brain malformations Akt3 , Hras , Mtor , Pik3ca cone-rod dystrophy Adam9 cone-rod dystrophy 3 Adam9 cone-rod dystrophy 9 Adam9 Congenital Cholesteatoma Cdkn1a congenital diaphragmatic hernia Cbl , Stat3 congenital disorder of glycosylation Ij Cbl congenital disorder of glycosylation type IIm Elk1 congenital fibrosis of the extraocular muscles Hras CONGENITAL HEART DEFECTS AND SKELETAL MALFORMATIONS SYNDROME Abl1 congenital heart disease Abl1 , Adam19 , Mapk1 , Sos1 congenital hypoplastic anemia Akt2 congenital myasthenic syndrome 13 Cbl congenital myasthenic syndrome 18 Pak5 congenital myasthenic syndrome 8 Prkcz Congenital Myopathy with Excess of Muscle Spindles Hras congestive heart failure Adam17 , Cbl , Erbb2 , Erbb4 , Gsk3b , Map2k1 , Map2k7 , Mapk10 , Mtor , Nrg1 , Prkca , Prkcb , Stat3 contact dermatitis Hsp90aa1 , Nrg1 Contrast-Induced Nephropathy Mapk8 Copper-Overload Cirrhosis Stat3 coronary artery disease Akt1 , Ptpn1 coronary restenosis Mapk1 , Myc Coronavirus infectious disease Egfr , Mapk1 , Mapk3 coronin-1A deficiency Mapk3 Costello syndrome Braf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11 COVID-19 Adam9 , Akt3 , Areg , Gper1 , Jun , Myc , Nrg1 , Stat1 Cowden syndrome Pik3ca Cowden syndrome 5 Pik3ca Cowden syndrome 6 Akt1 Craniofacial Abnormalities Egfr craniopharyngioma Braf craniosynostosis Akt2 , Ptpn11 crescentic glomerulonephritis Mtor Crohn's disease Stat3 Cryopyrin-Associated Periodic Syndromes Plcg2 cryptorchidism Cbl Currarino syndrome Pik3ca cutaneous leishmaniasis Pik3cd cutaneous Paget's disease Pik3ca Cytomegalovirus Infections Stat1 Dandy-Walker syndrome Braf degenerative disc disease Crk , Gsk3b delta beta-thalassemia Hras dementia Egfr , Nrg1 demyelinating disease Mapk1 , Myc dengue disease Mapk8 depressive disorder Abl1 , Gsk3b , Jun , Mapk1 , Stat3 dermatitis Egf , Egfr developmental and epileptic encephalopathy Hras , Pik3r3 developmental and epileptic encephalopathy 12 Pak5 developmental and epileptic encephalopathy 21 Ptpn6 developmental and epileptic encephalopathy 36 Pak3 developmental and epileptic encephalopathy 54 Akt3 Developmental Disabilities Akt3 , Braf , Camk2a , Camk2b , Cbl , Mapk3 , Pik3ca , Pik3r2 , Ptpn11 Developmental Disease Abl1 , Camk2b , Gnai1 , Sos2 diabetes mellitus Egfr , Ptpn1 Diabetes Mellitus, New-Onset after Transplantation Mtor Diabetic Cardiomyopathies Akt1 , Bad , Erbb2 , Erbb4 , Mapk1 , Mapk3 , Mtor , Nrg1 , Pik3ca Diabetic Cystopathy Bad diabetic encephalopathy Gsk3b Diabetic Nephropathies Cdkn1a , Cdkn1b , Egf , Gsk3b , Mapk1 , Mtor , Prkcb , Stat3 diabetic neuropathy Bad , Nrg1 diabetic retinopathy Akt1 , Egfr , Hras Diamond-Blackfan anemia Akt2 diaphragmatic eventration Pik3ca diffuse large B-cell lymphoma Braf , Myc , Pik3ca , Pik3cb , Pik3cd , Rps6kb1 , Stat3 DiGeorge syndrome Crkl , Mapk1 dilated cardiomyopathy Braf , Egfr , Erbb2 , Gsk3b , Kras , Prkca , Prkcb , Ptpn11 , Raf1 , Rps6kb1 , Sos1 dilated cardiomyopathy 1B Raf1 dilated cardiomyopathy 1LL Prkcz dilated cardiomyopathy 1NN Raf1 Dilated Cardiomyopathy with Left Ventricular Noncompaction Cbl , Raf1 disease by infectious agent Stat1 disease of cellular proliferation Braf , Erbb2 , Erbb3 , Hras , Kras , Map2k1 , Myc , Nras , Pik3ca , Pik3r1 , Src disease of metabolism Ptpn11 Disease Progression Egf , Egfr , Erbb2 , Erbb3 , Hras , Kras , Myc , Pik3ca , Stat1 distal 10q deletion syndrome Adam12 distal arthrogryposis type 1A Tln1 Dowling-Degos disease Adam10 Down syndrome Pik3ca Drug-Induced Dyskinesia Gsk3b , Mtor Duane retraction syndrome Ptpn11 Ductal Carcinoma Hsp90aa1 , Myc , Stat5a ductal carcinoma in situ Areg , Cdkn1a , Erbb2 , Erbb3 , Erbb4 , Pak2 , Prkca , Ptk2 , Src , Stat5a duodenal ulcer Stat3 Dwarfism Cbl , Mapk1 , Ptpn11 , Sos1 , Stat1 Dysbiosis Gper1 dysembryoplastic neuroepithelial tumor Braf dysplastic nevus syndrome Braf dystonia Camk2b early infantile epileptic encephalopathy Hras , Pik3r3 Ehlers-Danlos syndrome spondylodysplastic type 2 Prkcz Embryo Loss Cdkn1a embryonal rhabdomyosarcoma Ptpn11 Encephalocraniocutaneous Lipomatosis Kras end stage renal disease Hbegf , Mtor endocrine system disease Mtor endometrial adenocarcinoma Jun , Kras , Mapk1 , Mapk3 , Pik3r1 endometrial cancer Akt2 , Bad , Egf , Pik3cb , Pik3cd , Pik3r1 endometrial carcinoma Braf , Egfr , Grb2 , Gsk3b , Hras , Jun , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Prkca , Ptk2 endometrial hyperplasia Kras , Ptk2 Endometrial Hyperplasia without Atypia Kras Endometrial Intraepithelial Neoplasia Kras Endometrial Neoplasms Cdkn1a , Cdkn1b , Egf , Erbb2 , Erbb3 , Erbb4 , Gsk3b , Kras , Mapk3 , Myc , Pik3ca , Pik3cb , Stat3 Endometrioid Carcinomas Akt1 , Areg , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Kras , Mapk1 , Mapk3 , Pik3r2 endometriosis Areg , Egfr , Gper1 , Hbegf , Kras , Mapk8 , Ptk2 Endotoxemia Akt1 , Mapk8 , Stat5b Enteropathy-Associated T-Cell Lymphoma Stat5b Ependymomas Shc3 Epidermal Hyperplasia Stat3 epidermal nevus Hras , Kras , Nras , Pik3ca epilepsy Akt1 , Camk2d , Crkl , Erbb4 , Gnai1 , Mtor , Nrg1 , Pik3r2 epilepsy with generalized tonic-clonic seizures Hbegf episodic kinesigenic dyskinesia 1 Mapk3 erythropoietic protoporphyria Areg , Btc , Ereg esophageal atresia Stat5a esophageal cancer Akt1 , Pik3ca esophageal carcinoma Egfr , Erbb2 , Hras , Kras , Map2k7 , Myc , Pik3ca , Stat3 Esophageal Neoplasms Abl1 , Cdkn1a , Egfr , Erbb2 , Myc esophagus adenocarcinoma Abl1 , Pik3ca esophagus squamous cell carcinoma Akt1 , Cdkn1a , Egfr , Erbb4 essential hypertension Ptpn1 estrogen-receptor positive breast cancer Pik3ca exocrine pancreatic insufficiency Mtor Experimental Arthritis Adam10 , Adam17 , Akt1 , Cbl , Cblb , Egfr , Gsk3b , Mtor , Nras , Pik3cd , Stat1 , Stat3 Experimental Autoimmune Encephalomyelitis Adam17 , Cblb , Stat1 , Stat3 Experimental Autoimmune Uveitis Stat3 Experimental Autoimmune Uveoretinitis Stat3 Experimental Colitis Adam17 , Akt1 , Ereg , Mapk1 , Mapk3 Experimental Diabetes Mellitus Akt1 , Bad , Btc , Cdkn1a , Egfr , Hras , Hsp90aa1 , Mapk1 , Mapk3 , Mtor , Myc , Pik3r1 , Plcg1 , Prkca , Prkcb , Ptpn1 , Stat1 , Stat3 , Stat5b Experimental Leukemia Cbl , Nras , Ptpn11 Experimental Liver Cirrhosis Adam17 , Camk2d , Cdkn1a , Egf , Gab1 , Gsn , Mapk1 , Mapk3 , Mtor , Myc , Nrg1 , Prkcb , Ptk2 , Ptpn1 , Stat3 , Stat5a Experimental Liver Neoplasms Cdkn1a , Cdkn1b , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Myc , Nras , Stat3 , Tgfa Experimental Mammary Neoplasms Akt1 , Akt2 , Areg , Bad , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Gsk3b , Gsn , Hras , Map2k7 , Mapk1 , Mapk3 , Mtor , Myc , Pak4 , Pik3r1 , Ptk2 , Rasa1 , Stat1 , Stat3 , Stat5a , Tgfa Experimental Melanoma Braf Experimental Neoplasms Abl1 , Braf , Erbb2 , Hras , Kras , Nras , Pak1 , Stat3 Experimental Radiation Injuries Mapk1 , Mapk3 Experimental Sarcoma Kras , Nras extrahepatic cholestasis Jun , Mapk1 , Mapk3 , Mapk8 , Mapk9 extrapulmonary tuberculosis Ereg Facial Asymmetry Pik3ca facioscapulohumeral muscular dystrophy Cdkn1a Failure to Thrive Abl1 , Ptpn11 , Stat1 Fallopian Tube Neoplasms Cdkn1b familial adenomatous polyposis Akt1 , Egfr , Plcg1 familial adenomatous polyposis 1 Camk2a , Hbegf , Nrg2 , Rasa1 Familial Amyloidosis Gsn Familial Atrial Fibrillation 6 Mtor familial cold autoinflammatory syndrome Plcg2 familial cold autoinflammatory syndrome 2 Prkcg familial cold autoinflammatory syndrome 3 Plcg2 Familial Erythroleukemia Erbb3 familial hemophagocytic lymphohistiocytosis 5 Map2k7 familial hyperlipidemia Shc1 familial hypertrophic cardiomyopathy Raf1 , Sos1 familial melanoma Braf familial multiple nevi flammei Pik3ca familial partial lipodystrophy Akt2 Familial Prostate Cancer Cdkn1b , Map2k1 Familial Visceral Neuropathy Erbb3 Familial Visceral Neuropathy 2, Autosomal Recessive Erbb2 Febrile Seizures Nrg1 Female Infertility Mapk1 , Mapk3 Fetal Diseases Prkcb Fetal Growth Retardation Elk1 , Ptpn11 Fever Plcg2 , Stat3 fibrillary astrocytoma Kras Fibrosis Adam10 , Akt1 , Cdkn1b , Map2k7 , Stat3 Finnish type amyloidosis Gsn Focal Cortical Dysplasia of Taylor Mtor focal epilepsy Nras , Plcg1 , Src focal segmental glomerulosclerosis 5 Akt1 follicular dendritic cell sarcoma Stat3 Follicular Thyroid Cancer Braf , Hras , Nras frontotemporal dementia Erbb4 Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis Adam10 frontotemporal dementia and/or amyotrophic lateral sclerosis 6 Tln1 Frontotemporal Lobar Degeneration Hsp90aa1 Fuchs' endothelial dystrophy Cdkn1a Funnel Chest Ptpn11 galactosemia Tln1 gallbladder cancer Braf , Egf , Kras , Pik3ca gallbladder carcinoma Erbb2 , Erbb3 , Pik3ca , Tgfa Gallbladder Neoplasms Egfr , Erbb2 , Erbb3 , Erbb4 , Kras ganglioglioma Braf gas gangrene Gsn gastric adenocarcinoma Akt1 , Braf , Erbb2 , Erbb3 , Hras , Kras , Map2k1 , Map2k2 , Map2k4 , Mtor , Nras , Pik3ca , Ptpn11 , Raf1 , Stat1 , Stat3 , Stat5a , Stat5b gastric ulcer Bad , Egf , Mapk1 , Mapk3 , Nrg1 gastroenteritis Tgfa Gastrointestinal Neoplasms Erbb2 , Pik3ca gastrointestinal stromal tumor Abl2 , Akt3 , Braf , Kras , Shc1 generalized anxiety disorder Gper1 Generalized Epilepsy Mapk10 genetic disease Abl1 , Abl2 , Adam10 , Adam12 , Adam17 , Adam19 , Adam9 , Akt1 , Akt2 , Akt3 , Areg , Bad , Braf , Btc , Camk2a , Camk2b , Camk2d , Camk2g , Cbl , Cblb , Cblc , Cdkn1a , Cdkn1b , Crk , Crkl , Egf , Egfr , Eif4ebp1 , Elk1 , Erbb2 , Erbb3 , Erbb4 , Ereg , Gab1 , Gnai1 , Gnai3 , Gper1 , Grb2 , Gsk3b , Gsn , Hbegf , Hras , Hsp90aa1 , Jun , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk9 , Mtor , Myc , Nck1 , Nck2 , Nras , Nrg1 , Nrg2 , Nrg3 , Nrg4 , Pak1 , Pak2 , Pak3 , Pak4 , Pak5 , Pak6 , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pip5k1c , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Prkcz , Ptk2 , Ptpn1 , Ptpn11 , Ptpn6 , Ptprj , Raf1 , Rasa1 , Rps6kb1 , Rps6kb2 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2 , Src , Stat1 , Stat3 , Stat5a , Stat5b , Tgfa , Tln1 , Wasl Genetic Predisposition to Disease Egf , Tgfa Germ Cell and Embryonal Neoplasms Erbb2 germinoma Braf gingival fibromatosis Sos1 Gingival Fibromatosis 1 Sos1 glaucoma Bad , Cdkn1b , Jun , Ptpn11 glioblastoma Akt1 , Akt3 , Braf , Egf , Egfr , Hras , Kras , Map2k2 , Mtor , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Ptk2 , Stat3 , Stat5a Gliosis Mapk1 , Mapk3 glomerulonephritis Mapk1 glomerulosclerosis Hbegf , Shc1 Glucagonoma Btc glucose intolerance Pik3r1 glycogen storage disease II Pik3ca Glycogen Storage Disease XII Mapk3 Goldberg-Shprintzen syndrome Prkcz Growth Disorders Cbl , Pik3ca growth hormone insensitivity syndrome with immune dysregulation 1 Stat3 , Stat5a , Stat5b growth hormone insensitivity syndrome with immune dysregulation 2 Stat5b Growth Hormone Insensitivity with Immune Dysregulation Stat5b growth hormone secreting pituitary adenoma Cdkn1a Habitual Abortions Cdkn1a Haemophilus Infections Ptpn11 hairy cell leukemia Map2k1 head and neck cancer Egfr , Pik3ca Head and Neck Neoplasms Areg , Egfr , Mapk1 , Mapk3 , Pik3ca , Tgfa head and neck squamous cell carcinoma Abl1 , Akt1 , Braf , Egfr , Erbb2 , Erbb4 , Hras , Map2k1 , Map2k2 , Mapk1 , Pik3ca , Stat3 Hearing Loss Stat1 Hearing Loss, Cisplatin-Induced Camk2a , Camk2b , Gsk3b Hearing Loss, Noise-Induced Cdkn1a , Src heart disease Gsk3b , Stat3 heart valve disease Ptpn6 Heat Stroke Jun Helicobacter Infections Cdkn1b , Egf , Egfr , Erbb2 , Gab1 , Mapk8 , Ptpn11 HELLP syndrome Erbb2 hematologic cancer Cbl Hematologic Neoplasms Cbl Hemimegalencephaly Mtor , Pik3ca hemorrhagic disease Ptpn11 Hemorrhagic Shock Bad , Mapk1 , Mtor , Myc hepatitis Mapk8 , Mapk9 hepatitis C Myc , Stat1 hepatoblastoma Tgfa hepatocellular adenoma Cdkn1b , Hras , Kras , Ptpn11 hepatocellular carcinoma Abl1 , Akt1 , Akt2 , Braf , Cbl , Cdkn1a , Cdkn1b , Egf , Egfr , Erbb3 , Erbb4 , Ereg , Hras , Jun , Kras , Map2k2 , Map2k4 , Mapk1 , Mapk8 , Mtor , Myc , Nras , Nrg1 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Pik3r3 , Plcg1 , Ptk2 , Shc1 , Src , Stat1 , Stat3 , Stat5a , Stat5b , Tgfa Hepatomegaly Akt1 , Camk2a , Gper1 , Mtor hereditary ataxia Prkcg hereditary breast ovarian cancer syndrome Egfr , Kras , Pak4 , Plcg1 hereditary diffuse gastric cancer Kras hereditary hemorrhagic telangiectasia Rasa1 hereditary multiple exostoses Ptpn11 Hereditary Neoplastic Syndromes Akt1 , Camk2a , Cdkn1b , Egfr , Hbegf , Hras , Nrg2 , Pik3ca , Ptpn11 , Rasa1 hereditary renal cell carcinoma Egf hereditary spastic paraplegia Nrg1 hereditary spastic paraplegia 47 Nras hereditary spastic paraplegia 54 Adam9 , Eif4ebp1 hereditary spastic paraplegia 63 Gnai3 high grade glioma Akt2 , Areg , Bad , Braf , Camk2a , Camk2b , Cdkn1a , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Mapk3 , Mtor , Pik3ca , Pik3r3 , Prkca , Ptpn11 , Raf1 Hirschsprung's disease Erbb2 , Nrg1 , Nrg3 Hodgkin's lymphoma Jun , Kras , Mapk1 , Myc , Ptpn1 human immunodeficiency virus infectious disease Cdkn1a , Eif4ebp1 , Hsp90aa1 Human Influenza Stat1 Huntington's disease Egfr , Elk1 Hydrops Fetalis Hras , Kras , Ptpn11 hyper IgE recurrent infection syndrome 1 Stat3 , Stat5a , Stat5b hyper IgE syndrome Stat3 Hyperalgesia Camk2a , Erbb4 , Gper1 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Mtor , Nrg1 , Prkcb , Prkcg , Prkcz , Raf1 , Stat3 hyperglycemia Cbl , Prkcb , Prkcz , Shc1 hyperinsulinism Ptpn1 , Rps6kb1 Hyperoxia Cdkn1a hyperparathyroidism Myc hyperphosphatasia with impaired intellectual development syndrome 2 Tln1 Hyperphosphatemic Familial Tumoral Calcinosis 1 Ptpn6 Hyperplasia Akt1 , Cdkn1a , Egfr , Pik3ca Hypertelorism Pik3ca hypertension Akt1 , Akt2 , Bad , Egfr , Gnai3 , Gsk3b , Jun , Kras , Mapk8 , Mtor , Pik3r1 , Prkca , Prkcb , Ptk2 , Ptpn1 , Ptprj , Rps6kb1 , Src Hypertensive Nephropathy Shc1 hyperthyroidism Cdkn1b Hypertriglyceridemia Akt1 , Mtor hypertrophic cardiomyopathy Braf , Map2k2 , Myc , Ptpn11 , Raf1 , Sos1 hypertrophic cardiomyopathy 1 Raf1 , Sos1 hypertrophic cardiomyopathy 25 Erbb2 hypertrophic cardiomyopathy 4 Braf Hypertrophy Cdkn1a , Mapk1 , Mapk3 hyperuricemia Stat3 Hyperventilation Camk2b hypoglycemia Akt2 , Pik3r1 hypogonadotropic hypogonadism 2 with or without anosmia Adam9 , Eif4ebp1 hypoinsulinemic hypoglycemia with hemihypertrophy Akt2 Hypophosphatemic Rickets Hras Hypoproteinemia Rps6kb1 hypothyroidism Bad , Gsn Hypovolemia Cdkn1a Hypoxia Stat5b idiopathic generalized epilepsy Prkcz idiopathic interstitial pneumonia Mtor idiopathic pulmonary fibrosis Akt1 , Gper1 , Stat3 idiopathic scoliosis Ptpn11 IgA glomerulonephritis Adam10 Immediate Hypersensitivity Egfr IMMUNE DYSREGULATION, AUTOIMMUNITY, AND AUTOINFLAMMATION Plcg1 immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome Elk1 immune system disease Prkcb immunodeficiency 14 Mtor , Pik3cd immunodeficiency 16 Prkcz immunodeficiency 17 Cbl immunodeficiency 18 Cbl immunodeficiency 19 Cbl immunodeficiency 31A Stat1 immunodeficiency 31B Stat1 immunodeficiency 31C Stat1 immunodeficiency 36 Pik3r1 immunodeficiency 38 Prkcz immunodeficiency 39 Hras immunodeficiency 42 Shc1 impotence Akt1 , Bad in situ carcinoma Akt1 inclusion body myopathy with Paget disease of bone and frontotemporal dementia Egf Infantile Capillary Hemangioma Rasa1 Infectious Ectromelia Mapk8 infertility Cdkn1b Inflammation Akt1 , Camk2a , Egfr , Eif4ebp1 , Mtor , Ptpn1 , Stat3 , Tgfa inflammatory bowel disease Plcg2 , Stat3 inflammatory bowel disease 28 Cbl influenza Cdkn1b , Nrg1 , Ptpn11 influenza A Mapk8 Insulin Resistance Akt2 , Bad , Cblb , Egfr , Mapk3 , Pik3r1 , Prkcb , Prkcz , Ptpn1 , Shc1 insulinoma Btc , Tgfa Intellectual Developmental Disorder with Macrocephaly, Seizures, and Speech Delay Pak1 intellectual disability Bad , Braf , Camk2a , Camk2b , Camk2g , Crkl , Hras , Kras , Mapk1 , Mtor , Pak1 , Pak3 , Pik3r2 , Prkcg , Ptpn11 , Ptprj , Rps6kb2 , Sos1 intermediate coronary syndrome Akt1 intermittent claudication Bad interstitial cystitis Erbb2 , Erbb4 , Mtor , Nrg1 Intervertebral Disc Displacement Akt1 Intestinal Neoplasms Cdkn1a , Cdkn1b , Gsk3b , Mapk8 , Prkca Intestinal Polyps Jun intestinal pseudo-obstruction Erbb3 Intimal Hyperplasia Mapk1 intrahepatic cholangiocarcinoma Braf , Hsp90aa1 , Kras invasive ductal carcinoma Akt1 , Areg , Crkl , Erbb2 , Map2k4 invasive lobular carcinoma Erbb2 , Stat5a inverted papilloma Cdkn1a irritant dermatitis Stat3 ischemia Akt2 , Mapk9 , Prkca , Ptk2 , Raf1 isolated microphthalmia 5 Cbl Joubert syndrome 1 Rps6kb1 Joubert syndrome 25 Prkcz Joubert syndrome 3 Sos1 juvenile myelomonocytic leukemia Cbl , Kras , Nras , Ptpn11 juvenile rheumatoid arthritis Areg , Egf , Hbegf , Jun , Kras , Mapk1 , Nrg1 , Stat3 keratoacanthoma Pik3ca keratoconus Pak6 kidney angiomyolipoma Mtor kidney disease Cdkn1a , Egf , Mapk1 kidney failure Adam10 Kidney Neoplasms Akt1 , Braf , Cdkn1b , Eif4ebp1 , Erbb2 , Kras , Mapk1 , Mapk3 , Raf1 Kidney Reperfusion Injury Adam17 , Myc , Src Klatskin's tumor Kras Klippel-Feil syndrome 3 Ptpn6 Klippel-Trenaunay syndrome Pik3ca , Rasa1 Knee Osteoarthritis Hsp90aa1 , Tgfa Knobloch Syndrome Pak2 Knobloch Syndrome Type II Pak2 Kuhnt-Junius degeneration Mapk8 L-2-hydroxyglutaric aciduria Sos2 Langerhans-cell histiocytosis Braf large cell carcinoma Prkca large congenital melanocytic nevus Hras , Nras Larsen syndrome Camk2a Laryngeal Neoplasms Egfr laryngeal squamous cell carcinoma Cdkn1a , Egfr , Erbb2 , Erbb3 , Erbb4 , Map2k4 , Plcg1 larynx cancer Map2k7 learning disability Ptpn11 Leber congenital amaurosis Hras , Pik3ca Left Ventricular Hypertrophy Adam17 , Cdkn1b , Egfr , Hbegf , Mapk1 , Mtor , Myc , Prkca , Prkcb , Prkcz , Ptk2 , Rasa1 , Rps6kb1 , Shc1 leiomyoma Egfr , Gper1 , Myc , Ptk2 Lennox-Gastaut syndrome Mapk10 lethal congenital contracture syndrome 2 Erbb3 lethal congenital contracture syndrome 3 Pip5k1c leukemia Bad , Nras , Prkcz , Ptpn11 leukocyte adhesion deficiency 3 Bad Leukocytosis Kras , Nras Leukoencephalopathies Cdkn1b Lewy body dementia Elk1 Leydig cell tumor Cdkn1b limb ischemia Ptpn1 linear nevus sebaceous syndrome Hras , Kras , Nras Lip Neoplasms Cdkn1a lipoid nephrosis Cdkn1a listeriosis Pik3cd liver benign neoplasm Cdkn1a liver cancer Hras , Pik3ca liver carcinoma Hras , Nras liver cirrhosis Egfr , Hras , Myc , Shc1 , Stat1 , Stat3 Liver Injury Myc , Stat3 Liver Metastasis Braf , Map2k7 , Nras , Src Liver Neoplasms Abl1 , Braf , Cdkn1a , Cdkn1b , Gper1 , Hras , Jun , Kras , Myc , Raf1 , Stat3 , Stat5b , Tgfa Liver Reperfusion Injury Bad , Gsk3b , Mapk8 localized scleroderma Cdkn1a long QT syndrome 10 Cbl lung adenocarcinoma Adam19 , Akt1 , Braf , Egf , Egfr , Erbb2 , Erbb3 , Erbb4 , Hras , Kras , Map2k1 , Map2k4 , Map2k7 , Myc , Nras , Pik3ca , Pik3r1 , Plcg1 , Ptpn11 , Ptprj , Raf1 , Rasa1 , Sos1 , Src lung cancer Braf , Cdkn1b , Egfr , Erbb2 , Kras , Map2k4 , Myc , Pik3ca , Plcg1 lung carcinoma Braf , Crkl , Egfr , Kras , Map2k7 , Pik3ca lung disease Egfr , Gsn Lung Injury Mtor , Tgfa lung metastasis Cblb , Src Lung Neoplasms Akt1 , Braf , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Hras , Jun , Kras , Map2k7 , Mapk1 , Mapk3 , Mtor , Myc , Nrg1 , Pik3ca , Raf1 , Stat5a lung non-small cell carcinoma Abl1 , Akt1 , Akt2 , Akt3 , Areg , Bad , Braf , Cbl , Cblb , Cdkn1a , Cdkn1b , Egf , Egfr , Eif4ebp1 , Erbb2 , Erbb3 , Hras , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mtor , Myc , Nras , Pik3ca , Plcg1 , Prkcb , Raf1 , Stat3 , Stat5b , Tgfa lung oat cell carcinoma Akt1 , Pik3ca Lung Reperfusion Injury Kras , Myc lung sarcomatoid carcinoma Kras lung small cell carcinoma Akt1 , Cdkn1b , Egfr , Mtor , Myc , Pik3ca , Pik3r1 , Ptk2 lung squamous cell carcinoma Akt1 , Braf , Cblb , Egfr , Hras , Kras , Map2k1 , Map2k7 , Pik3ca , Ptk2 , Ptpn11 , Ptprj , Src lupus nephritis Egf , Mtor , Stat1 Lymphangiectasis Raf1 lymphangioleiomyomatosis Stat1 , Stat3 lymphangioma Braf Lymphatic Metastasis Braf , Cbl , Cblb , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Mtor , Pik3ca , Pik3cb , Ptk2 , Src , Stat3 lymphocytic choriomeningitis Stat1 lymphoma Kras , Nras , Ptpn11 lymphopenia Cbl lymphoproliferative syndrome Stat3 lymphoproliferative syndrome 2 Ptpn6 Lynch syndrome Kras , Sos1 Macrocephaly Akt3 , Mtor , Pik3ca Macrocephaly Mesodermal Hamartoma Spectrum Akt1 macular degeneration Bad , Cdkn1a , Cdkn1b major depressive disorder Nrg1 male infertility Cbl malignant astrocytoma Akt1 , Akt2 , Akt3 , Braf , Camk2g , Kras , Ptpn11 malignant mesothelioma Cdkn1a , Egfr , Raf1 malignant ovarian germ cell neoplasm Cbl mammary Paget's disease Erbb2 Mandibular Neoplasms Braf mantle cell lymphoma Eif4ebp1 , Gsk3b , Mtor , Pik3cd maple syrup urine disease Akt2 maturity-onset diabetes of the young type 1 Akt2 , Pak4 maxillary sinus squamous cell carcinoma Cdkn1a median neuropathy Egfr , Erbb2 , Erbb3 , Erbb4 , Nrg1 Mediastinal Neoplasms Ptpn1 medulloblastoma Erbb2 , Myc , Nras , Pik3ca , Stat3 megacolon Akt3 , Crkl , Mapk8 Megalencephaly - Cutis Marmorata Telangiectatica Congenita Akt3 , Pik3ca , Pik3r1 , Pik3r2 Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome Akt3 , Pik3ca , Pik3r2 Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 Pik3r2 Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2 Akt3 Megalodactyly Pik3ca melanoma Akt1 , Braf , Cdkn1a , Erbb2 , Erbb4 , Gper1 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mtor , Nras , Pik3ca , Pik3r1 , Raf1 melorheostosis Map2k1 membranoproliferative glomerulonephritis Cdkn1b membranous glomerulonephritis Cdkn1b Memory Disorders Abl1 , Akt1 , Mapk1 , Mapk3 , Stat3 Meningeal Neoplasms Akt1 meningioma Akt1 Mercury Poisoning, Nervous System Jun Merkel cell carcinoma Myc Mesothelioma Cdkn1b , Egfr , Gsn , Mtor metabolic dysfunction-associated steatotic liver disease Mapk8 , Prkca , Stat3 Metabolic Syndrome Gsn , Map2k2 metachondromatosis Ptpn11 Metaplasia Egf MHC class II deficiency Shc1 microcephaly Abl1 , Camk2b , Cbl , Pak3 , Ptpn11 Microsatellite Instability Braf middle cerebral artery infarction Bad , Camk2a , Gsk3b , Gsn , Mapk1 , Mapk3 , Mtor , Nrg1 , Prkcg , Stat3 migraine Map2k2 mitochondrial metabolism disease Camk2a morphine dependence Mapk1 , Mapk3 mosaic variegated aneuploidy syndrome 1 Pak6 Mouth Neoplasms Erbb2 , Erbb3 , Hras , Kras , Nras , Pik3ca , Ptk2 movement disease Nrg1 mucolipidosis type IV Map2k7 mucositis Tgfa multicentric Castleman disease Map2k2 Multiple Abnormalities Gper1 , Gsk3b , Kras Multiple Basal Cell Carcinoma Rasa1 multiple endocrine neoplasia Cdkn1b multiple endocrine neoplasia type 4 Cdkn1b multiple myeloma Braf , Cbl , Hras , Kras , Nras , Pik3ca , Pik3r2 , Ptpn11 Multiple Organ Failure Mapk1 multiple sclerosis Cblb Multisystem Autoimmune Disease, Infantile-Onset, 1 Stat3 Multisystem Autoimmune Disease, Infantile-Onset, 3 Cblb Muscle Hypotonia Sos1 muscular atrophy Akt1 , Gsk3b , Kras , Mtor , Rps6kb1 Muscular Dystrophy, Animal Mtor Musculoskeletal Abnormalities Abl1 Mycobacterium Infections Stat1 myelodysplastic syndrome Cdkn1b , Erbb2 , Hras , Kras , Myc , Nras myelofibrosis Src myeloid leukemia associated with Down Syndrome Nras , Ptpn11 Myeloid Leukemia, Chronic-Phase Abl1 myeloid neoplasm Cbl , Kras , Nras myeloid sarcoma Kras myocardial infarction Akt1 , Camk2d , Cdkn1b , Erbb2 , Erbb4 , Gsk3b , Gsn , Mapk1 , Mapk8 , Mtor , Nrg1 , Rps6kb1 Myocardial Ischemia Areg , Camk2d , Crk , Eif4ebp1 , Erbb2 , Stat5a Myocardial Reperfusion Injury Akt1 , Akt2 , Bad , Cbl , Gsk3b , Mapk1 , Mapk3 , Mapk8 , Prkcb , Stat1 , Stat3 myoepithelioma Braf Nasal Polyps Jun , Stat3 nasal type extranodal NK/T-cell lymphoma Stat3 , Stat5b Nasopharyngeal Neoplasms Egfr , Hras , Nras , Pik3ca nasopharynx carcinoma Erbb3 , Map2k4 , Src , Stat3 NATURAL KILLER CELL ENTEROPATHY Erbb4 , Pik3cb Nematode Infections Pik3r1 Neointima Akt1 , Erbb4 , Nrg1 , Pak1 Neonatal Hypoglycemia, Simulating Foetopathia Diabetica Akt2 Neonatal Inflammatory Skin and Bowel Disease 1 Adam17 Neonatal Inflammatory Skin and Bowel Disease 2 Egfr Neoplasm Invasiveness Egf , Egfr , Hras , Mapk1 , Mapk3 , Nrg1 , Pak1 , Ptk2 , Src , Stat3 , Tln1 Neoplasm Metastasis Akt2 , Braf , Cdkn1a , Egf , Egfr , Erbb2 , Erbb3 , Erbb4 , Hsp90aa1 , Kras , Map2k4 , Mapk1 , Mapk3 , Mapk9 , Mtor , Myc , Pik3ca , Pik3r3 , Ptk2 , Src , Stat1 , Stat3 , Stat5a Neoplasm Recurrence, Local Egfr , Erbb2 Neoplastic Cell Transformation Egf , Gsk3b , Hras , Jun , Kras , Mapk8 , Myc , Nrg1 , Ptk2 , Stat3 Neoplastic Processes Hras nephritis Mtor , Ptk2 nephroblastoma Braf , Cdkn1b , Erbb2 , Myc , Pak1 , Stat1 , Stat3 nephrogenic diabetes insipidus Prkca nephrotic syndrome Nck1 , Nck2 nephrotoxicity Camk2a Nerve Degeneration Mapk1 , Mapk3 , Nrg1 , Tgfa Nervous System Malformations Camk2b Nervous System Trauma Stat1 Neuralgia Src neuroblastoma Hras , Kras , Map2k4 , Map2k7 , Myc , Nras , Pak4 , Pik3ca , Ptpn11 Neurocutaneous Melanosis Nras neurodegeneration with brain iron accumulation 5 Elk1 NEURODEVELOPMENTAL DISORDER WITH BEHAVIORAL ABNORMALITIES, ABSENT SPEECH, AND HYPOTONIA Pak1 NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, IMPAIRED SPEECH, AND BEHAVIORAL ABNORMALITIES Gnai1 NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES Pik3ca Neurodevelopmental Disorders Abl1 , Akt3 , Camk2a , Camk2b , Camk2d , Camk2g , Cbl , Crkl , Erbb4 , Gnai1 , Hbegf , Hsp90aa1 , Mapk3 , Mtor , Nras , Nrg2 , Pak1 , Pik3cd , Pik3r1 , Pip5k1c , Prkcz , Ptpn11 , Ptpn6 , Rasa1 , Sos1 , Stat1 neuroectodermal tumor Myc neuroendocrine tumor Braf , Cdkn1b neurofibroma Ptpn11 neurofibromatosis-Noonan syndrome Map2k2 , Ptpn11 neurofibrosarcoma Nras neuronal ceroid lipofuscinosis Hras , Map2k1 neuronal ceroid lipofuscinosis 1 Rps6kb1 neuronal ceroid lipofuscinosis 6A Gsk3b , Mapk1 , Mapk3 neuronal intestinal dysplasia type A Erbb3 neutropenia Stat3 Nevus Braf newborn respiratory distress syndrome Braf Niemann-Pick disease Abl1 Niemann-Pick disease type C1 Abl1 , Stat3 non-Hodgkin lymphoma Braf , Map2k1 , Myc , Nras , Pik3ca non-syndromic X-linked intellectual disability Pak3 non-syndromic X-linked intellectual disability 30 Pak3 Nonseminomatous Germ Cell Tumor Braf nonsyndromic deafness Tgfa Nontuberculous Mycobacterium Infections Stat1 Noonan Like Syndrome Cbl , Ptpn11 , Sos1 Noonan syndrome Braf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1 , Sos2 Noonan syndrome 1 Braf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1 , Sos2 Noonan syndrome 13 Mapk1 Noonan syndrome 3 Hras , Kras , Ptpn11 , Raf1 , Sos1 Noonan syndrome 4 Sos1 Noonan syndrome 5 Raf1 Noonan syndrome 6 Nras Noonan syndrome 7 Braf Noonan syndrome 8 Pik3ca Noonan syndrome 9 Sos2 Noonan syndrome with multiple lentigines Braf , Map2k2 , Ptpn11 , Raf1 Noonan syndrome with multiple lentigines 1 Ptpn11 Noonan syndrome with multiple lentigines 2 Raf1 Noonan syndrome with multiple lentigines 3 Braf Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic Leukemia Cbl , Ptpn11 Nuchal Bleb, Familial Sos1 obesity Akt1 , Akt2 , Bad , Cdkn1b , Egfr , Mapk1 , Mapk3 , Mtor , Myc , Pik3r1 , Prkcb , Ptpn1 , Rps6kb1 , Stat3 obsessive-compulsive disorder Hras obstructive sleep apnea Nrg1 occupational asthma Prkca ocular hypertension Cdkn1a oculoectodermal syndrome Kras oligodendroglioma Camk2b , Egf Ollier disease Ptpn11 Optic Nerve Injuries Jun Oral Lichen Planus Cdkn1a oral mucosa leukoplakia Cdkn1a oral squamous cell carcinoma Abl1 , Cdkn1a , Egfr , Erbb2 , Erbb4 , Gsk3b , Jun , Plcg1 osteoarthritis Adam12 , Bad , Mtor , Pik3r1 Osteoarthritis, Experimental Mapk3 Osteochondroma Ptpn11 osteopetrosis Jun osteoporosis Abl1 , Gsn , Myc , Tln1 osteosarcoma Akt1 , Cbl , Egfr , Jun , Myc otitis media Btc ovarian cancer Akt1 , Cdkn1b , Crkl , Egf , Egfr , Erbb2 , Hras , Nrg1 , Pik3ca , Prkca , Stat3 ovarian carcinoma Akt2 , Erbb2 , Map2k1 , Pak1 , Prkca , Ptk2 , Raf1 ovarian germ cell cancer Cbl Ovarian Neoplasms Akt1 , Akt2 , Areg , Braf , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Ereg , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk3 , Mtor , Myc , Pak1 , Pik3ca , Pik3r1 , Stat3 ovarian serous carcinoma Map2k4 ovarian serous cystadenocarcinoma Braf , Erbb2 , Hras , Nras , Pik3ca ovary adenocarcinoma Erbb2 ovary serous adenocarcinoma Kras overactive bladder syndrome Nrg1 Oxygen-Induced Retinopathy Mapk8 , Stat3 Pain Akt1 , Nrg1 pancreatic acinar cell adenocarcinoma Braf , Src pancreatic adenocarcinoma Akt3 , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Raf1 , Stat1 pancreatic cancer Adam9 , Akt1 , Akt2 , Bad , Braf , Egf , Egfr , Kras , Map2k4 , Mtor , Myc , Stat3 , Tgfa pancreatic carcinoma Cdkn1a , Kras , Mtor , Raf1 pancreatic ductal adenocarcinoma Mapk8 , Pik3r2 pancreatic ductal carcinoma Adam9 , Cdkn1a , Egf , Kras , Mapk3 pancreatic intraductal papillary-mucinous neoplasm Akt1 pancreatic mucinous cystadenoma Kras pancreatitis Egf , Map2k1 papillary renal cell carcinoma Braf , Erbb2 , Hras , Mtor , Pik3ca papilloma Cdkn1a , Egfr , Erbb2 , Hras , Map2k4 , Tgfa papillomavirus infectious disease Egfr paraganglioma Cdkn1b paraplegia Adam9 , Akt1 , Eif4ebp1 Paraproteinemias Braf , Hras , Kras , Nras , Pik3ca , Ptpn11 Parasitic Liver Diseases Kras parathyroid adenoma Hras parathyroid carcinoma Abl2 , Akt3 , Shc1 Paratuberculosis Gsn Parkinson's disease Abl1 , Akt1 , Egf , Egfr , Erbb2 , Gsk3b , Mapk1 , Mapk3 Parkinsonism Bad , Egfr , Mapk8 , Mtor , Src patent ductus arteriosus Ptpn11 patent foramen ovale Ptpn11 Penile Neoplasms Hras , Kras , Pik3ca peptic esophagitis Egfr perinatal necrotizing enterocolitis Egf , Hbegf periodontitis Stat1 , Stat3 peripartum cardiomyopathy Stat3 Peripheral Nerve Injuries Cbl , Cblb peripheral nervous system disease Erbb4 , Jun peritonitis Gsk3b peroxisome biogenesis disorder 2B Ptpn6 Peroxisome Biogenesis Disorder, Complementation Group 7 Prkcz PHACE Association Braf phencyclidine abuse Camk2b pheochromocytoma Cdkn1b phobic disorder Hras Phyllodes Tumor Cdkn1a , Egfr , Erbb3 , Erbb4 Pigmented Nevus Hras , Nras pilocytic astrocytoma Kras pituitary adenoma Cdkn1b Pituitary Neoplasms Cdkn1a , Cdkn1b , Prkca Pituitary Stalk Interruption Syndrome Raf1 plasma cell neoplasm Braf , Hras , Kras , Nras , Pik3ca , Ptpn11 pleomorphic xanthoastrocytoma Braf , Camk2b , Egfr , Gnai1 , Wasl Pneumococcal Meningitis Adam17 Pneumococcal Pneumonia Mapk1 , Mapk3 pneumonia Egf Poisoning Gsk3b polycystic kidney disease Mtor , Myc , Pik3ca , Plcg1 polycystic kidney disease 1 Myc polycystic ovary syndrome Akt2 , Camk2d , Gab1 , Nrg1 polymicrogyria Akt3 Polyuria Prkca Port-Wine Stain Rasa1 portal hypertension Hsp90aa1 , Mapk1 , Mtor , Pik3r1 Postoperative Atrial Fibrillation Gsn Postoperative Cognitive Dysfunction Mapk1 , Mapk3 pre-eclampsia Erbb2 , Gsn pre-malignant neoplasm Abl1 , Akt1 , Cdkn1a , Egf , Eif4ebp1 , Hras , Map2k7 , Mapk8 , Mapk9 , Stat3 , Stat5a Premature Aging Cdkn1a Premature Birth Braf Prenatal Exposure Delayed Effects Adam10 Preterm Intraventricular Hemorrhage Gsn primary biliary cholangitis Cdkn1a , Rps6kb1 primary cerebellar degeneration Prkcg primary ciliary dyskinesia Tln1 primary coenzyme Q10 deficiency 7 Abl1 primary cutaneous T-cell non-Hodgkin lymphoma Braf , Plcg1 , Stat5b primary hyperparathyroidism Cdkn1b primary hypomagnesemia Egf primary immunodeficiency disease Crkl , Pik3cd , Pik3r1 , Stat1 , Stat3 Primary Lymphedema with Myelodysplasia Nck1 primary open angle glaucoma Cdkn1a primary ovarian insufficiency Myc prolactinoma Myc proliferative diabetic retinopathy Ptpn1 prostate adenocarcinoma Akt1 , Akt2 , Akt3 , Braf , Erbb2 , Grb2 , Hras , Jun , Map2k1 , Mapk1 , Myc , Pik3ca , Pik3cb , Raf1 , Stat1 prostate cancer Akt1 , Akt2 , Akt3 , Cdkn1a , Egfr , Erbb2 , Erbb3 , Erbb4 , Grb2 , Kras , Map2k7 , Mapk10 , Mtor , Myc , Nras , Pak4 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Ptk2 , Raf1 , Sos1 , Src , Stat3 , Stat5a Prostate Cancer, Hereditary, 1 Braf , Hras , Kras , Nras prostate carcinoma Akt2 , Bad , Crkl , Jun , Prkca , Stat3 prostate carcinoma in situ Areg , Cdkn1b , Kras , Map2k4 , Map2k7 , Myc prostatic hypertrophy Bad , Myc Prostatic Neoplasms Adam9 , Akt1 , Akt2 , Areg , Bad , Braf , Cdkn1a , Cdkn1b , Egf , Egfr , Erbb2 , Erbb3 , Gsk3b , Hras , Jun , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk3 , Mapk9 , Mtor , Myc , Pak6 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Prkcz , Raf1 , Stat3 , Stat5b , Tgfa proteasome-associated autoinflammatory syndrome 1 Cdkn1a proteinuria Nck1 , Nck2 , Pak1 , Pak2 Proteus syndrome Akt1 Pseudomonas Infections Mapk8 psoriasis Areg , Cdkn1a , Stat3 , Tgfa psoriatic arthritis Stat3 psychotic disorder Nrg1 PTEN hamartoma tumor syndrome Pik3ca ptosis Ptpn11 , Sos1 pulmonary artery disease Gsn pulmonary edema Tgfa pulmonary emphysema Jun pulmonary fibrosis Areg , Bad , Egf , Egfr , Mtor , Stat1 , Stat3 , Tgfa pulmonary hypertension Cdkn1a , Cdkn1b , Egfr , Mapk1 , Mapk3 , Mtor , Myc , Ptk2 , Tgfa Pulmonary Hypertension, Hypoxia-Induced Egfr pulmonary tuberculosis Akt1 , Egfr , Ereg , Jun pulmonary valve stenosis Braf , Hras , Sos1 Puromycin Aminonucleoside Nephrosis Pak2 Pyogenic Granuloma Nras , Stat3 Radiation Pneumonitis Cblb radiculopathy Erbb4 RASopathy Braf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1 , Sos2 rectal benign neoplasm Cdkn1b , Egfr , Mapk8 , Nras , Pik3ca , Pik3cb rectum adenocarcinoma Stat3 Recurrence Erbb2 , Erbb3 , Hras , Kras Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations Rps6kb2 renal carcinoma Jun , Mtor renal cell carcinoma Akt1 , Akt3 , Bad , Cdkn1b , Egfr , Erbb2 , Erbb4 , Jun , Kras , Map2k1 , Mapk1 , Mtor , Myc , Nras , Pak1 , Pik3ca , Pik3r1 , Stat3 Renal Cell Carcinoma 1 Mtor , Nras , Pik3ca renal fibrosis Adam17 , Kras , Mapk1 , Myc renal hypertension Cdkn1a renal hypomagnesemia 3 Egf renal hypomagnesemia 4 Egf renal hypomagnesemia 5 with ocular involvement Egf renovascular hypertension Camk2d Reoviridae Infections Stat1 Reperfusion Injury Akt1 , Bad , Cdkn1a , Cdkn1b , Egf , Gnai3 , Hbegf , Jun , Mapk8 , Mapk9 , Pik3r1 , Prkca , Ptk2 , Src , Stat1 , Stat3 , Stat5a , Stat5b respiratory allergy Ptpn6 reticulate acropigmentation of Kitamura Adam10 Retina Reperfusion Injury Bad , Map2k4 , Stat3 retinal degeneration Cdkn1a , Pak3 , Pak4 RETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIES Cdkn1a Retinal Neovascularization Mtor retinitis pigmentosa Adam9 , Prkcg Rett syndrome Ptpn1 rhabdoid cancer Myc rhabdomyosarcoma Cbl , Hras rheumatic myocarditis Gsn rheumatoid arthritis Hsp90aa1 , Pik3r1 , Ptk2 , Stat1 , Stat3 Right Ventricular Hypertrophy Akt1 , Egfr , Mtor , Prkca , Ptk2 , Ptpn11 , Tgfa Roifman-Chitayat Syndrome Pik3cd rosette-forming glioneuronal tumor Pik3ca Salivary Gland Neoplasms Cdkn1a , Hras sarcoidosis Cdkn1a sarcoma Pik3ca Sarcopenia Cdkn1a schizophrenia Akt1 , Camk2b , Cbl , Crkl , Egf , Egfr , Elk1 , Erbb4 , Gsk3b , Map2k7 , Mapk3 , Mapk8 , Mtor , Nrg1 , Nrg3 , Nrg4 , Pak1 , Pak2 , Pak3 , Pik3cb , Pik3cd schizophrenia 6 Nrg1 sciatic neuropathy Cdkn1b , Gsk3b , Mtor , Nrg1 scoliosis Ptpn11 scrapie Stat1 , Stat3 sebaceous gland neoplasm Cdkn1a Sebaceous Nevus Syndrome and Hemimegalencephaly Hras , Kras , Nras seborrheic keratosis Pik3ca seminoma Hras , Kras senile cataract Cdkn1b Senior-Loken syndrome Akt3 Senior-Loken Syndrome 7 Akt3 sensorineural hearing loss Gab1 , Prkcb , Src Sepsis Bad , Cdkn1a , Gsk3b , Gsn , Mapk1 , Mapk3 , Mapk8 , Mtor , Stat1 , Stat3 Sepsis-Associated Encephalopathy Stat3 Septic Peritonitis Pik3r1 serous cystadenocarcinoma Cdkn1a severe acute respiratory syndrome Egfr , Mapk1 , Mapk3 , Stat1 severe congenital neutropenia 3 Shc1 severe congenital neutropenia 5 Shc1 Sezary's disease Braf , Cdkn1b , Mapk1 , Plcg1 shigellosis Egf Shock Mapk1 , Mapk3 SHORT syndrome Pik3r1 Shprintzen-Goldberg Craniosynostosis Prkcz silicosis Jun , Prkcb skin benign neoplasm Hras skin cancer Crkl skin melanoma Akt1 , Braf , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mtor , Myc , Nras , Pik3ca , Pik3r1 , Raf1 , Stat3 Skin Neoplasms Akt1 , Cdkn1a , Erbb4 , Hras , Map2k4 , Stat3 skin papilloma Nrg1 Sleep Deprivation Map2k4 small cell carcinoma Mtor small intestine adenocarcinoma Map2k1 , Map2k2 Small-For-Size Syndrome Bad Smith-Kingsmore Syndrome Mtor , Pik3r1 , Pik3r2 Smith-Magenis syndrome Map2k2 spastic ataxia Pik3r5 spermatocytoma Hras Spinal Cord Injuries Akt1 , Cdkn1b , Egfr , Erbb3 , Gper1 , Jun , Mtor , Nrg1 , Prkcg Spinal Cord Reperfusion Injury Bad spinocerebellar ataxia type 14 Prkcg Spinocerebellar Ataxias Prkcg Splenic Neoplasms Hras Splenomegaly Kras , Nras , Stat5b split hand-foot malformation 5 Pdk1 spondylocostal dysostosis 5 Mapk3 Sporadic Papillary Renal Cell Carcinoma Braf , Erbb2 , Hras , Mtor , Myc , Pik3ca squamous cell carcinoma Adam19 , Akt1 , Areg , Cdkn1a , Egfr , Hras , Kras , Mapk1 , Mapk3 , Myc , Pik3ca , Ptk2 , Ptpn11 , Rasa1 , Stat3 Staphylococcal Pneumonia Akt1 , Ptpn11 status epilepticus Adam10 , Adam9 , Gsk3b , Jun , Mtor , Prkcb , Src steatotic liver disease Akt1 , Mapk8 , Myc , Shc1 stomach cancer Abl1 , Egfr , Erbb2 , Kras , Map2k7 , Pik3ca , Ptpn11 , Src , Stat3 stomach carcinoma Cblb , Cdkn1a , Erbb2 , Erbb3 , Erbb4 , Kras Stomach Neoplasms Areg , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Hbegf , Hras , Jun , Kras , Mapk1 , Mapk3 , Mapk8 , Myc , Nras , Pik3ca , Prkcb , Stat3 , Tgfa strabismus Ptpn11 Streptococcus pneumonia Pik3cd stress-related disorder Nrg1 Stroke Akt1 , Cbl , Erbb4 , Mapk8 , Pak1 , Pik3ca , Ptpn1 , Raf1 , Sos1 , Src , Tgfa Sturge-Weber syndrome Map2k1 , Rasa1 Subarachnoid Hemorrhage Erbb4 , Gsk3b , Gsn , Nrg1 , Pik3cb , Stat3 substance abuse Nrg1 substance-induced psychosis Akt1 , Camk2b substance-related disorder Gsk3b Sudden Unexpected Nocturnal Death Syndrome Sos1 syndromic microphthalmia 5 Adam17 syndromic X-linked intellectual disability Lubs type Elk1 , Pak3 systemic lupus erythematosus Cdkn1a T-cell acute lymphoblastic leukemia Kras , Mtor , Ptpn11 , Stat1 , Stat3 , Stat5b T-cell large granular lymphocyte leukemia Stat5b T-cell non-Hodgkin lymphoma Akt1 , Cdkn1a , Hras , Stat3 , Stat5b T-cell prolymphocytic leukemia Stat5b T-Lymphocytopenia Stat5b Tachycardia Gsk3b tauopathy Gsk3b temporal lobe epilepsy Mtor Temporomandibular Joint Disorders Mtor Temtamy syndrome Ptpn6 teratoma Erbb4 , Kras Testicular Neoplasms Cdkn1b Testis Reperfusion Injury Mapk1 , Mapk3 tethered spinal cord syndrome Braf tetralogy of Fallot Ptpn11 thoracic aortic aneurysm Adam10 , Adam17 thrombocytopenia Ptpn11 Thrombocytopenia 10 Ptprj Thrombocytopenia 6 Src Thromboembolism Gsn thrombosis Pik3cb thymoma Hras thyroid cancer Mapk1 , Myc Thyroid Carcinoma, Nonmedullary 1 Kras thyroid gland follicular carcinoma Kras thyroid gland medullary carcinoma Kras thyroid gland papillary carcinoma Braf , Myc Thyroid Neoplasms Akt1 , Akt2 , Braf , Cdkn1a , Hras , Kras , Mapk1 , Nras , Pak1 , Pik3ca Tobacco Use Disorder Egfr , Nrg1 Tongue Neoplasms Cdkn1a , Hras , Stat3 tongue squamous cell carcinoma Cdkn1a , Egfr , Erbb3 , Erbb4 , Jun , Map2k4 toxic encephalopathy Mtor toxic shock syndrome Pik3cd transient cerebral ischemia Bad , Camk2a , Cbl , Elk1 , Map2k4 , Mtor , Nrg1 , Stat3 transitional cell carcinoma Akt1 , Areg , Braf , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Hras , Kras , Map2k1 , Mapk1 , Mtor , Nras , Pak1 , Pik3ca Transplant Rejection Myc Trauma and Stressor Related Disorders Pak1 , Src traumatic brain injury Adam10 , Bad Trichilemmoma Hras trichorhinophalangeal syndrome type I Erbb4 , Myc tricuspid valve insufficiency Ptpn11 trigeminal neuralgia Mapk1 , Mapk3 , Mapk8 , Mapk9 , Prkcg Triple Negative Breast Neoplasms Kras tuberculosis Ereg , Nrg1 tuberous sclerosis Eif4ebp1 Tympanic Membrane Perforation Egf type 1 diabetes mellitus Btc , Cbl , Cblb , Egfr , Stat3 type 2 diabetes mellitus Adam17 , Akt1 , Akt2 , Bad , Braf , Btc , Egfr , Gsk3b , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Mtor , Pak4 , Pik3cb , Pik3r1 , Prkcb , Prkcz , Ptpn1 , Src , Stat3 ulcerative colitis Cdkn1a , Stat3 uremia Ptk2 ureteral obstruction Abl1 , Adam10 , Adam12 , Adam17 , Adam19 , Akt1 , Mapk1 , Mapk3 , Mtor , Pak2 urethral obstruction Mapk1 urinary bladder cancer Akt1 , Areg , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Gsk3b , Hras , Kras , Map2k4 , Map2k7 , Mtor , Myc , Pik3ca , Prkca , Src , Stat3 Urinary Bladder Neoplasm Erbb3 , Hras , Kras Urinary Incontinence Mapk1 Urologic Neoplasms Erbb2 uterine cancer Braf , Erbb2 , Erbb3 , Hras , Kras , Map2k1 , Mtor , Nras , Pik3ca , Pik3r1 , Sos1 uterine carcinosarcoma Erbb2 , Erbb3 , Hras , Pik3ca , Pik3r1 Uterine Cervical Neoplasms Adam9 , Akt1 , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Hras , Kras , Mapk1 , Mtor , Myc , Pik3ca , Stat3 Uterine Neoplasms Cdkn1b , Kras vascular dementia Gsk3b , Mapk1 , Mtor Vascular Malformations Braf , Kras , Map2k1 , Pik3ca , Pik3r1 , Rasa1 Vascular Remodeling Egfr vasculitis Cbl velocardiofacial syndrome Crkl , Mapk1 Ventilator-Induced Lung Injury Akt1 , Erbb2 Ventricular Dysfunction, Left Pik3ca Ventricular Fibrillation Egfr Ventricular Premature Complexes Ptpn11 Ventricular Remodeling Gsn ventricular septal defect Braf Ventricular Tachycardia Ptpn11 , Raf1 , Sos1 Viral Bronchiolitis Stat5a Viral Myocarditis Nrg1 visceral leishmaniasis Pik3cd visual epilepsy Bad , Erbb4 , Nrg1 vitiligo Pik3r1 vulva cancer Akt1 Wallerian Degeneration Erbb2 , Erbb3 Weight Gain Gsn , Pik3ca Weissenbacher-Zweymuller syndrome Mapk1 Werner syndrome Ptpn11 Williams-Beuren syndrome Src Wilson disease Camk2a withdrawal disorder Gnai1 , Mapk1 , Mapk3 Wounds and Injuries Egf , Ptpn1 X-linked agammaglobulinemia Pik3r1 X-linked epilepsy with variable learning disabilities and behavior disorders Elk1 X-linked severe congenital neutropenia Elk1 Zollinger-Ellison syndrome Egf