EPIDERMAL GROWTH FACTOR/NEUREGULIN SIGNALING PATHWAY (PW:0000170)

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Description

Epidermal growth factor/neuregulin signaling pathway plays a central role in the regulation of cell growth, differentiation, proliferation and survival. At least eleven ligands bind to four receptors to activate downstream signaling pathways, primarily the Raf/Mek/Erk MAPK and the phosphatidylinositol 3-Akt cascades (reports point to activation of Stat proteins in certain cancer cell lines). The ligands are type 1 transmembrane proteins whose extracellular domain must be cleaved in order to free

Pathway Diagram:

Ariadne Genomics Inc. Erbb3 --+> phosphatidylinositol 3-kinase-Akt signaling pathway Sos2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos1 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Erbb4 Erbb3 Sos1 Adams ---> Nrg ligands Adams ---> Egfr/Erbb4 ligands Adams ---> Egfr ligands Erbb4 ---- Nrg ligands Erbb3 ---- Nrg ligands Egfr/Erbb4 ligands ---- Erbb4 Egfr ---- Egfr/Erbb4 ligands Egfr ---- Egfr ligands the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> cell differentiation phosphatidylinositol 3-kinase-Akt signaling pathway ---> cell proliferation phosphatidylinositol 3-kinase-Akt signaling pathway ---> pro-growth the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> pro-growth the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> cell proliferation pro-growth phosphatidylinositol 3-kinase-Akt signaling pathway cell proliferation phosphatidylinositol 3-kinase-Akt signaling pathway ---> cell survival the extracellular signal-regulated Raf/Mek/Erk signaling pathway Egfr ---- Shc1 Erbb4 ---- Grb2 Erbb2 ---- Shc1 Egfr ---- Grb2 Grb2 ---- Shc1 Grb2 ---- Sos2 Grb2 Grb2 ---- Sos1 Pik3r1 Shc1 Erbb4 ---- Shc1 Egfr cell differentiation cell survival Erbb2 Erbb3 ---- Pik3r1 Ptprj ---| Egfr Cbl Cbl ---| Egfr Egfr ligands Egfr/Erbb4 ligands Adams Ptprj Sos2 Nrg ligands
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Genes in Pathway:

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epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:6907045
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase JBrowse link 13 74,154,533 74,333,244 RGD:6907045
G Adam10 ADAM metallopeptidase domain 10 JBrowse link 8 77,107,355 77,237,483 RGD:2317976
G Adam12 ADAM metallopeptidase domain 12 JBrowse link 1 205,951,840 206,286,294 RGD:2317976
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:2317976
G Adam19 ADAM metallopeptidase domain 19 JBrowse link 10 31,146,107 31,240,582 RGD:2317976
G Adam9 ADAM metallopeptidase domain 9 JBrowse link 16 71,810,377 71,887,926 RGD:2317976
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Areg amphiregulin JBrowse link 14 18,521,921 18,531,179 RGD:1578718
RGD:2317963
RGD:6484113
RGD:6907045
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Btc betacellulin JBrowse link 14 18,231,854 18,270,621 RGD:2317963
RGD:2324625
RGD:6484113
RGD:6907045
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:6907045
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:6907045
G Camk2d calcium/calmodulin-dependent protein kinase II delta JBrowse link 2 230,900,907 231,132,207 RGD:6907045
G Camk2g calcium/calmodulin-dependent protein kinase II gamma JBrowse link 15 3,936,721 3,995,740 RGD:6907045
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:2317988
RGD:6907045
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:6907045
G Cblc Cbl proto-oncogene C JBrowse link 1 80,699,321 80,716,146 RGD:6907045
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6907045
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6907045
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:6907045
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:1626483
RGD:2317963
RGD:6484113
RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:1581898
RGD:1581908
RGD:2317963
RGD:6484113
RGD:6907045
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:6907045
G Elk1 ELK1, ETS transcription factor JBrowse link X 1,287,875 1,304,822 RGD:6907045
G Epgn epithelial mitogen JBrowse link 14 18,627,103 18,635,135 RGD:2317963
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:2317963
RGD:6484113
RGD:6907045
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:1642700
RGD:2289958
RGD:2317965
RGD:2317988
RGD:6484113
RGD:6907045
G Erbb4 erb-b2 receptor tyrosine kinase 4 JBrowse link 9 75,021,790 76,178,936 RGD:2317965
RGD:6907045
G Ereg epiregulin JBrowse link 14 18,577,620 18,591,395 RGD:2317963
RGD:6484113
RGD:6907045
G Gab1 GRB2-associated binding protein 1 JBrowse link 19 30,794,290 30,903,819 RGD:6484113
RGD:6907045
G Gnai1 G protein subunit alpha i1 JBrowse link 4 13,405,136 13,486,866 RGD:6484113
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:6484113
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:2317988
RGD:6484113
RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6907045
G Gsn gelsolin JBrowse link 3 14,456,106 14,508,922 RGD:6484113
G Hbegf heparin-binding EGF-like growth factor JBrowse link 18 29,330,302 29,340,185 RGD:1581908
RGD:2317963
RGD:6484113
RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6484113
RGD:6907045
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:6484113
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6907045
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6484113
RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6484113
RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Mtor mechanistic target of rapamycin JBrowse link 5 165,263,813 165,373,967 RGD:6907045
G Myc myelocytomatosis oncogene JBrowse link 7 102,586,313 102,591,240 RGD:6907045
G Nck1 NCK adaptor protein 1 JBrowse link 8 108,787,797 108,847,779 RGD:6484113
RGD:6907045
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:6484113
RGD:6907045
G Nras neuroblastoma RAS viral oncogene homolog JBrowse link 2 205,553,119 205,563,716 RGD:6484113
RGD:6907045
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:2317965
RGD:6907045
G Nrg2 neuregulin 2 JBrowse link 18 28,835,391 29,015,552 RGD:1304015
RGD:2317965
RGD:6484113
RGD:6907045
G Nrg3 neuregulin 3 JBrowse link 16 15,763,031 16,932,208 RGD:2317965
RGD:6484113
RGD:6907045
G Nrg4 neuregulin 4 JBrowse link 8 59,782,789 59,849,433 RGD:2317965
RGD:6484113
RGD:6907045
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:6484113
RGD:6907045
G Pak2 p21 (RAC1) activated kinase 2 JBrowse link 11 72,829,407 72,865,815 RGD:6907045
G Pak3 p21 (RAC1) activated kinase 3 JBrowse link X 114,784,452 115,042,683 RGD:6907045
G Pak4 p21 (RAC1) activated kinase 4 JBrowse link 1 85,162,462 85,201,746 RGD:6907045
G Pak6 p21 (RAC1) activated kinase 6 JBrowse link 3 110,442,175 110,486,317 RGD:6907045
G Pak7 p21 (RAC1) activated kinase 7 JBrowse link 3 129,042,232 129,357,512 RGD:6907045
G Pdk1 pyruvate dehydrogenase kinase 1 JBrowse link 3 58,530,870 58,561,494 RGD:1642700
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6484113
RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6484113
RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:2317988
RGD:6484113
RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6484113
RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6484113
RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma JBrowse link 7 11,267,207 11,294,291 RGD:6484113
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:6484113
RGD:6907045
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:6907045
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6907045
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6907045
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:1642700
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:6907045
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:6484113
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:6484113
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:6484113
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:2317988
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rasa1 RAS p21 protein activator 1 JBrowse link 2 13,617,021 13,696,531 RGD:6484113
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6907045
G Rps6kb2 ribosomal protein S6 kinase B2 JBrowse link 1 219,406,201 219,412,888 RGD:6907045
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:2317988
RGD:6907045
G Shc2 SHC adaptor protein 2 JBrowse link 7 12,948,952 12,971,174 RGD:6907045
G Shc3 SHC adaptor protein 3 JBrowse link 17 13,670,520 13,791,043 RGD:6907045
G Shc4 SHC adaptor protein 4 JBrowse link 3 117,897,738 117,990,289 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:1581110
RGD:2317988
RGD:6484113
RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:2317988
RGD:6907045
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:1581134
RGD:6484113
RGD:6907045
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6484113
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6484113
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:6907045
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:6907045
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:2317963
RGD:6484113
RGD:6907045
G Tln1 talin 1 JBrowse link 5 59,033,635 59,063,592 RGD:6484113
G Wasl Wiskott-Aldrich syndrome-like JBrowse link 4 51,677,722 51,726,212 RGD:6484113
altered epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:5490965
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:5133241
RGD:5133242
RGD:5490965
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:4143515
RGD:5133243
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:5490965

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassAdamsAdam members
Functional ClassEgfr/Erbb4 ligandsepidermal growth factor receptor
Functional ClassNrg ligandsneuregulin ligands

Pathway Gene Annotations

Disease Annotations Associated with Genes in the epidermal growth factor/neuregulin signaling pathway
Disease TermsGene Symbols
2-HydroxyglutaricaciduriaSos2
Abnormalities, MultipleGsk3b , Kras , Mapk1
Activated PI3K-delta SyndromePik3cd
Acute Coronary SyndromeGsn
Acute ErythroleukemiaErbb3
Acute Kidney InjuryBad , Cdkn1b , Egf , Egfr , Gsk3b , Hbegf , Mtor , Myc , Tgfa
Acute Lung InjuryEgfr , Pak1
Acute-Phase ReactionStat5b
AdenocarcinomaAbl1 , Egfr , Erbb2 , Kras , Mtor , Myc , Pik3ca , Ptpn11 , Stat3 , Stat5a
Adenocarcinoma of EsophagusPik3ca
Adenocarcinoma of LungBraf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Myc , Pik3ca , Rasa1 , Sos1
Adenocarcinoma, Bronchiolo-AlveolarEgfr , Kras
Adenocarcinoma, ColorectalCdkn1a
Adenocarcinoma, FollicularKras
AdenomaKras
Adenoma, Liver CellCdkn1b , Hras , Kras
Adenomatous Polyposis ColiAkt1 , Egfr
Adrenocortical CarcinomaBraf , Egfr
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Aging, PrematureCdkn1a
AIDS-Associated NephropathyEgf , Mtor
AlbuminuriaNck1 , Nck2
Alzheimer DiseaseAbl1 , Akt1 , Bad , Egf , Egfr , Elk1 , Gsk3b , Hras , Hsp90aa1 , Mapk10 , Mapk8 , Mapk9 , Nrg1 , Pak1 , Pik3r1 , Shc1 , Stat3
Alzheimer Disease 18Adam10
AmeloblastomaBraf
AmnesiaGnai1 , Gnai3
Amphetamine-Related DisordersAkt1 , Nrg1
AmyloidosisGsn
Amyloidosis, FamilialGsn
Amyotrophic Lateral SclerosisAkt1 , Gsk3b
Amyotrophic Lateral Sclerosis 1Shc1
Amyotrophic Lateral Sclerosis 19Erbb4
Angina, UnstableAkt1
AngiomyolipomaMtor , Stat1 , Stat3
AniridiaCamk2d
AnoxiaStat5b
Anti-Glomerular Basement Membrane DiseaseMapk8
Aortic Aneurysm, AbdominalMapk8
Aortic Aneurysm, ThoracicAdam10 , Adam17
Aortic Valve InsufficiencyEgfr , Ptpn11
Aortic Valve StenosisEgfr , Ptpn11
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arrhythmias, CardiacMap2k4
Arsenic PoisoningCdkn1a
ArteriosclerosisMapk9
Arteriovenous MalformationsRasa1
Arthritis, ExperimentalAkt1 , Cbl , Cblb , Egfr , Gsk3b , Mtor , Nras , Pik3cd , Stat1 , Stat3
Arthritis, JuvenileAreg , Hbegf , Jun , Kras , Mapk1 , Nrg1 , Stat3
Arthritis, PsoriaticStat3
Arthritis, RheumatoidHsp90aa1 , Ptk2 , Stat1 , Stat3
AsphyxiaJun
AsthmaAreg , Egfr
AstrocytomaAkt1 , Braf , Kras , Ptpn11
Ataxia-Oculomotor Apraxia 3Pik3r5
AtherosclerosisAkt1 , Stat3
Atrial FibrillationCdkn1a
AtrophyMapk3 , Rps6kb1 , Stat3
Auriculo-condylar syndromeGnai3
Autism Spectrum DisorderMapk3
Autistic DisorderHras , Prkcb , Stat3
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1Stat3
Autoimmune DiseasesStat3
Autoimmune Lymphoproliferative SyndromeNras
Autoimmune Lymphoproliferative Syndrome, Type IVKras , Nras
Autoinflammation, Antibody Deficiency, and Immune Dysregulation, PLCG2-AssociatedPlcg2
Bardet-Biedl SyndromeAkt3
Barrett EsophagusCdkn1a
Behcet SyndromeStat3
Benign Skin NeoplasmsHras
Bile Duct NeoplasmsEgfr
Bipolar DisorderAkt1 , Gsk3b
BlisterAdam17
Bowen's DiseaseCdkn1a
Brain DeathMap2k4
Brain InjuriesAkt1 , Bad , Cdkn1a , Cdkn1b , Elk1 , Gsk3b , Gsn , Jun , Stat1 , Stat3
Brain IschemiaAkt1 , Bad , Jun , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Pak1 , Prkca , Src , Stat3
Breast AdenocarcinomaAkt1 , Kras , Pik3ca
Breast Cancer, FamilialPik3r3
Breast NeoplasmsAbl1 , Adam10 , Akt1 , Akt2 , Areg , Bad , Cdkn1a , Cdkn1b , Crkl , Egfr , Erbb2 , Erbb3 , Erbb4 , Hras , Hsp90aa1 , Jun , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Myc , Nrg1 , Pak1 , Pak2 , Pik3ca , Pik3r1 , Plcg1 , Prkca , Ptk2 , Raf1 , Rps6kb2 , Src , Stat1 , Stat3 , Stat5a
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Akt1 , Pik3ca
Burkitt LymphomaMyc , Pik3r1
BurnsBad , Gsk3b , Mtor , Rps6kb1
Cafe au lait Spots, MultipleSos1
CalcinosisErbb2 , Ptpn6
Candidiasis, Chronic MucocutaneousStat1
Candidiasis, Familial, 7Stat1
Capillary Malformation-Arteriovenous MalformationRasa1
CarcinogenesisAbl1 , Braf , Erbb2 , Gsk3b , Kras
CarcinomaCdkn1a , Egfr , Hras , Kras , Myc , Pik3r1 , Rasa1 , Stat3 , Stat5a
Carcinoma in SituAkt1
Carcinoma, Adenoid CysticHras , Map2k2 , Pik3ca
Carcinoma, Basal CellErbb2 , Pik3ca , Rasa1
Carcinoma, DuctalStat5a
Carcinoma, Ductal, BreastCrkl , Map2k4
Carcinoma, EndometrioidAreg , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Kras
Carcinoma, HepatocellularAkt2 , Braf , Cdkn1b , Egfr , Hras , Jun , Kras , Mtor , Myc , Pik3ca , Ptk2 , Shc1 , Stat1 , Tgfa
Carcinoma, Intraductal, NoninfiltratingCdkn1a , Erbb2 , Erbb3 , Erbb4 , Pak2 , Prkca , Ptk2 , Src , Stat5a
Carcinoma, Large CellPrkca
Carcinoma, LobularErbb2 , Stat5a
Carcinoma, Merkel CellMyc
Carcinoma, Non-Small-Cell LungAkt1 , Areg , Braf , Cbl , Egfr , Erbb2 , Hras , Kras , Map2k1 , Myc , Nras , Pik3ca , Raf1 , Stat3 , Tgfa
Carcinoma, Pancreatic DuctalAdam9 , Cdkn1a , Egf , Kras
Carcinoma, Renal CellAkt1 , Bad , Cdkn1b , Egfr , Erbb2 , Erbb4 , Jun , Kras , Map2k1 , Mtor , Myc , Pak1 , Pik3ca , Stat3
Carcinoma, Small CellMtor
Carcinoma, Squamous CellAkt1 , Areg , Cdkn1a , Egfr , Hras , Kras , Mapk1 , Mapk3 , Myc , Pik3ca , Ptk2 , Ptpn11 , Rasa1 , Stat3
Carcinoma, Squamous Cell of Head and NeckAkt1 , Egfr , Pik3ca , Stat3
Carcinoma, Transitional CellAreg , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Hras , Kras , Nras , Pak1
Cardiac FibrosisPak1
Cardiofaciocutaneous SyndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Bad , Egfr , Gsk3b , Mapk1 , Mapk8 , Mtor , Myc , Pak1 , Prkca , Prkcb , Rps6kb1 , Shc1 , Src , Stat3
CardiomyopathiesAkt1 , Kras , Mapk1 , Mapk3 , Stat3
Cardiomyopathy, DilatedEgfr , Erbb2 , Kras , Prkca , Prkcb , Ptpn11 , Raf1 , Rps6kb1
CARDIOMYOPATHY, DILATED, 1NNRaf1
Cardiomyopathy, HypertrophicKras , Myc , Ptpn11 , Raf1 , Sos1
Cardiomyopathy, Hypertrophic, FamilialKras , Raf1 , Sos1
Cardiovascular AbnormalitiesMap2k1
Carotid Artery InjuriesCbl , Myc
Cecal NeoplasmsKras
Cell Transformation, NeoplasticHras , Jun , Kras , Mapk8 , Myc , Nrg1 , Ptk2 , Stat3
Cerebral HemorrhageMtor
Ceroid Lipofuscinosis, Neuronal 1, InfantileRps6kb1
Ceroid Lipofuscinosis, Neuronal, 6Gsk3b , Mapk1 , Mapk3
Cervical Intraepithelial NeoplasiaAdam9 , Cdkn1a , Cdkn1b , Stat3
Charcot-Marie-Tooth DiseaseNrg1
ChloracneCdkn1b , Egfr
CholangiocarcinomaEgfr , Erbb2 , Kras
Cholesteatoma, CongenitalCdkn1a
Cholesteatoma, Middle EarCdkn1a
ChondrosarcomaMtor
Choroidal NeovascularizationStat3
Chromosome BreakageMyc
Chronic Allograft DysfunctionMtor
Chronic Lymphoid LeukemiaMyc
Churg-Strauss SyndromeStat3
Clear-Cell Metastatic Renal Cell CarcinomaMyc
Cleft LipMyc
Cleft PalateMyc
Cocaine-Related DisordersCamk2a , Camk2b , Mapk1 , Mapk3
ColitisAdam17 , Src
Colonic NeoplasmsAkt1 , Akt2 , Bad , Braf , Cdkn1a , Crkl , Egfr , Erbb2 , Jun , Kras , Myc , Nras , Pik3ca , Pik3r1 , Ptprj , Src , Stat3
Colorectal NeoplasmsAkt1 , Braf , Egfr , Erbb4 , Kras , Nras , Pik3ca , Prkcb , Ptprj
Cone-Rod Dystrophy 9Adam9
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Copper-Overload CirrhosisStat3
Coronary Artery DiseaseAkt1
Coronary RestenosisMapk1 , Myc
Costello SyndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
COWDEN SYNDROME 5Pik3ca
Craniofacial AbnormalitiesEgfr
CraniopharyngiomaBraf
Crohn DiseaseStat3
CryptorchidismCbl
Currarino TriadPik3ca
Cystadenocarcinoma, SerousCdkn1a
Cystitis, InterstitialMtor
Cytomegalovirus InfectionsStat1
DementiaEgfr , Nrg1
Dementia, VascularMtor
Demyelinating DiseasesMyc
Depressive DisorderGsk3b , Jun
Dermatitis, AtopicMapk8
Dermatitis, ContactHsp90aa1 , Nrg1
Dermatitis, IrritantStat3
Developmental DisabilitiesAkt3 , Cbl
Diabetes Insipidus, NephrogenicPrkca
Diabetes Mellitus, ExperimentalAkt1 , Bad , Btc , Cdkn1a , Egfr , Hras , Hsp90aa1 , Mapk1 , Mapk3 , Myc , Pik3r1 , Plcg1 , Prkca , Prkcb , Stat1 , Stat3 , Stat5b
Diabetes Mellitus, New-Onset after TransplantationMtor
Diabetes Mellitus, Type 1Btc , Cbl , Cblb , Egfr , Stat3
Diabetes Mellitus, Type 2Adam17 , Akt1 , Akt2 , Bad , Btc , Egfr , Gsk3b , Pik3r1 , Prkcb , Ptpn1 , Src , Stat3
Diabetic CardiomyopathiesBad , Erbb2 , Erbb4 , Nrg1
Diabetic CystopathyBad
Diabetic NephropathiesCdkn1b , Egf , Mapk1 , Mtor , Prkcb , Stat3
Diabetic NeuropathiesBad , Nrg1
Diabetic RetinopathyEgfr , Hras
DiGeorge SyndromeCrkl
Disease Models, AnimalAkt1 , Erbb2 , Hbegf , Kras , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Prkcg , Stat3
Disease ProgressionEgfr , Erbb2 , Erbb3 , Hras , Myc , Stat1
Dowling-Degos DiseaseAdam10
Drug-Induced Liver InjuryBad , Gsn , Wasl
Duodenal UlcerStat3
Dysembryoplastic Neuroepithelial TumorBraf
Dyskinesia, Drug-InducedMtor
Encephalomyelitis, Autoimmune, ExperimentalAdam17 , Cblb , Stat1 , Stat3
EnchondromatosisPtpn11
Endometrial HyperplasiaKras , Ptk2
Endometrial NeoplasmsCdkn1a , Cdkn1b , Erbb2 , Erbb3 , Erbb4 , Jun , Kras , Myc , Pik3ca , Prkca , Ptk2 , Stat3
EndometriosisAreg , Egfr , Hbegf , Kras , Ptk2
EndotoxemiaStat5b
Enterocolitis, NecrotizingEgf , Hbegf
Epidermal HyperplasiaStat3
Epidermal NevusHras , Kras , Nras , Pik3ca
EpilepsyAkt1
Epilepsy, GeneralizedMapk10
Epilepsy, Temporal LobeMtor
Epilepsy, Tonic-ClonicHbegf
Epileptic Encephalopathy, Lennox-Gastaut TypeMapk10
Erectile DysfunctionAkt1 , Bad
Erythroleukemia, FamilialErbb3
Esophageal NeoplasmsAbl1 , Cdkn1a , Egfr , Erbb2 , Myc
Esophageal Squamous Cell CarcinomaCdkn1a , Egfr
Esophagitis, PepticEgfr
Exostoses, Multiple HereditaryPtpn11
Facial AsymmetryPik3ca
Fallopian Tube NeoplasmsCdkn1b
Familial Cold Autoinflammatory Syndrome 3Plcg2
Fatty LiverMapk8 , Myc , Shc1
Fetal DiseasesPrkcb
Fetal Growth RetardationElk1 , Ptpn11
FeverStat3
Fibromatosis, GingivalSos1
Fibromatosis, Gingival, 1Sos1
FibrosisAkt1 , Cdkn1b , Map2k7 , Stat3
Frontotemporal Lobar DegenerationHsp90aa1
Fuchs' Endothelial DystrophyCdkn1a
Gallbladder NeoplasmsEgf , Egfr , Erbb2 , Erbb3 , Erbb4 , Kras , Tgfa
GastroenteritisTgfa
Gastrointestinal NeoplasmsErbb2 , Pik3ca
Genetic Diseases, InbornMapk1 , Pik3r2
Genetic Predisposition to DiseaseTgfa
GerminomaBraf
Giant Pigmented Hairy NevusHras , Nras
GlaucomaBad , Cdkn1b
Glaucoma, Primary Open AngleCdkn1a
GlioblastomaAkt1 , Egfr , Erbb2 , Myc , Ptk2
GliomaAkt2 , Areg , Bad , Braf , Egfr , Erbb2 , Pik3ca , Raf1
GliosisMapk1 , Mapk3
GlomerulonephritisMapk1
Glomerulonephritis, CrescenticMtor
Glomerulonephritis, MembranoproliferativeCdkn1b
Glomerulonephritis, MembranousCdkn1b
GlucagonomaBtc
Granuloma, PyogenicStat3
Growth DisordersCbl , Pik3ca
Growth Hormone-Secreting Pituitary AdenomaCdkn1a
Hamartoma Syndrome, MultipleAkt1 , Egfr , Pik3ca
Head and Neck NeoplasmsAreg , Egfr , Mapk1 , Mapk3 , Tgfa
Hearing LossStat1
Hearing Loss, Cisplatin-InducedCamk2a , Camk2b , Gsk3b
Hearing Loss, Noise-InducedCdkn1a
Heart ArrestAkt1
Heart Defects, CongenitalAdam19
Heart DiseasesStat3
Heart FailureCbl , Erbb2 , Erbb4 , Gsk3b , Map2k7 , Mtor , Nrg1 , Prkca , Prkcb
Heart Septal Defects, VentricularBraf
Heart Valve DiseasesPtpn6
Heat StrokeJun
Helicobacter InfectionsCdkn1b
HELLP SyndromeErbb2
Hemangioma, CapillaryAkt3
HemangiosarcomaHras , Jun , Kras , Myc , Plcg1 , Stat3
HemimegalencephalyPik3ca
Hepatitis C, ChronicStat3
Hepatitis, ChronicShc1 , Stat3
HepatoblastomaTgfa
Hepatolenticular DegenerationCamk2a
Hernias, Diaphragmatic, CongenitalCbl , Stat3
Hirschsprung DiseaseErbb2 , Nrg1
HIV InfectionsCdkn1a , Eif4ebp1 , Hsp90aa1
Hodgkin DiseaseJun , Ptpn1
Huntington DiseaseEgfr , Elk1
Hyper-Ige Recurrent Infection Syndrome, Autosomal DominantStat3
HyperalgesiaCamk2a , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Mtor , Nrg1 , Prkcb , Prkcg , Raf1 , Stat3
HyperglycemiaCbl , Prkcb , Prkcz , Shc1
HyperinsulinismRps6kb1
HyperlipidemiasShc1
HyperoxiaCdkn1a
HyperparathyroidismMyc
Hyperparathyroidism, PrimaryCdkn1b
HyperplasiaAkt1 , Cdkn1a , Egfr , Pik3ca
Hypersensitivity, ImmediateEgfr
HypertensionAkt1 , Akt2 , Bad , Egfr , Gsk3b , Jun , Kras , Mapk8 , Mtor , Pik3r1 , Prkca , Prkcb , Ptk2 , Ptprj , Rps6kb1 , Src
Hypertension, PortalHsp90aa1 , Mtor , Pik3r1
Hypertension, PulmonaryCdkn1a , Cdkn1b , Egfr , Mtor , Myc , Ptk2 , Tgfa
Hypertension, RenalCdkn1a
Hypertensive NephropathyShc1
HypertriglyceridemiaMtor
HypertrophyMapk1 , Mapk3
Hypertrophy, Left VentricularCdkn1b , Egfr , Hbegf , Mtor , Myc , Prkca , Prkcb , Prkcz , Ptk2 , Rasa1 , Rps6kb1 , Shc1
Hypertrophy, Right VentricularAkt1 , Mtor , Prkca , Ptk2 , Tgfa
HyperuricemiaStat3
HypoglycemiaAkt2 , Pik3r1
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
Hypomagnesemia PrimaryEgf
HypoproteinemiaRps6kb1
HypothyroidismBad , Gsn
HypovolemiaCdkn1a
Idiopathic Interstitial PneumoniasMtor
Idiopathic Pulmonary FibrosisStat3
Immune System DiseasesPrkcb
Immunodeficiency 14Pik3cd
Immunodeficiency 36Pik3r1
Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal DementiaEgf
Infarction, Middle Cerebral ArteryBad , Mtor , Nrg1 , Stat3
Infertility, FemaleMapk1 , Mapk3
InflammationAkt1 , Camk2a , Egfr , Mtor , Stat3 , Tgfa
Inflammatory Bowel Disease 11Cdkn1a , Stat3
Inflammatory Skin and Bowel Disease, NeonatalAdam17
Influenza, HumanStat1
Insulin ResistanceAkt2 , Bad , Cblb , Egfr , Pik3r1 , Prkcb , Prkcz , Ptpn1 , Shc1
InsulinomaBtc , Tgfa
Intellectual DisabilityCamk2g , Kras , Prkcg
Intermittent ClaudicationBad
Intervertebral Disc DegenerationCrk
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsCdkn1a , Cdkn1b , Prkca
Intestinal PolypsJun
IschemiaAkt2 , Mapk9 , Prkca , Ptk2 , Raf1
Ischemic Attack, TransientBad , Cbl , Elk1 , Map2k4 , Stat3
Job SyndromeStat3
Keratosis, SeborrheicPik3ca
Kidney DiseasesCdkn1a , Mapk1
Kidney Failure, ChronicHbegf , Mtor
Kidney NeoplasmsAkt1 , Braf , Cdkn1b , Eif4ebp1 , Erbb2 , Jun , Kras , Mapk1 , Mapk3 , Raf1
Kidney Reperfusion InjuryMyc , Src
Laron Syndrome Type 2Stat5b
Laryngeal NeoplasmsCdkn1a , Egfr
LeiomyomaMyc , Ptk2
LEOPARD SyndromeBraf , Ptpn11 , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD syndrome, 2Raf1
Lethal Congenital Contractural Syndrome 3Pip5k1c
Lethal Congenital Contracture Syndrome 2Erbb3
LeukemiaBad , Nras , Prkcz , Ptpn11
Leukemia, B-CellMyc
Leukemia, Erythroblastic, AcuteErbb3
Leukemia, ExperimentalCbl , Nras
Leukemia, Hairy CellMap2k1
Leukemia, Large Granular LymphocyticStat3 , Stat5b
Leukemia, Lymphocytic, Chronic, B-CellCbl
Leukemia, Megakaryoblastic, of Down SyndromeNras
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveAbl1 , Abl2
Leukemia, Myeloid, AcuteAbl1 , Cbl , Cdkn1b , Eif4ebp1 , Kras , Myc , Nras , Stat3
Leukemia, Myeloid, Chronic-PhaseAbl1
Leukemia, Myelomonocytic, ChronicNras
Leukemia, Myelomonocytic, JuvenileCbl , Kras , Nras , Ptpn11
Leukemia, Promyelocytic, AcuteAkt1 , Myc , Nras
Leukemia, T-CellStat3
Leukemia-Lymphoma, Adult T-CellNras , Plcg1 , Prkcb , Stat3
LeukoencephalopathiesCdkn1b
Leukoplakia, OralCdkn1a
Lewy Body DiseaseElk1
Leydig Cell TumorCdkn1b
Lichen Planus, OralCdkn1a
Lip NeoplasmsCdkn1a
Lipodystrophy, Familial PartialAkt2
Liver CirrhosisStat1 , Stat3
Liver Cirrhosis, BiliaryCdkn1a , Rps6kb1
Liver Cirrhosis, ExperimentalAdam17 , Camk2d , Cdkn1a , Gsn , Mtor , Myc , Nrg1 , Prkcb , Ptk2 , Ptpn1
Liver Diseases, ParasiticKras
Liver Failure, AcuteMapk8
Liver InjuryMyc , Stat3
Liver NeoplasmsAbl1 , Braf , Cdkn1a , Cdkn1b , Hras , Jun , Kras , Myc , Pik3ca , Raf1 , Stat3 , Tgfa
Liver Neoplasms, ExperimentalCdkn1a , Hras , Kras , Map2k1 , Myc , Tgfa
Liver Reperfusion InjuryBad , Mapk8
Lung DiseasesEgfr , Gsn
Lung InjuryMtor , Tgfa
Lung NeoplasmsAkt1 , Braf , Cdkn1a , Cdkn1b , Crkl , Egfr , Erbb2 , Erbb3 , Hras , Jun , Kras , Map2k7 , Mapk1 , Mapk3 , Mtor , Myc , Pik3ca , Raf1 , Stat5a
Lung Reperfusion InjuryMyc
Lupus NephritisEgf , Mtor
LymphangioleiomyomatosisStat1 , Stat3
Lymphatic MetastasisCdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Stat3
LymphomaKras , Nras
Lymphoma, B-CellNras , Ptpn1
Lymphoma, Large B-Cell, DiffusePik3ca , Pik3cb , Pik3cd , Rps6kb1
Lymphoma, Large-Cell, AnaplasticHsp90aa1 , Stat3
Lymphoma, Mantle-CellEif4ebp1 , Gsk3b , Mtor , Pik3cd
Lymphoma, Non-HodgkinBraf
Lymphoma, T-CellAkt1 , Cdkn1a , Stat3 , Stat5b
Lymphoma, T-Cell, CutaneousBraf , Plcg1 , Stat5b
LymphopeniaCbl
Lymphoproliferative DisordersStat3
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
Macular DegenerationBad , Cdkn1a , Cdkn1b
Malformations of Cortical DevelopmentAkt3 , Mtor , Pik3ca
Malformations of Cortical Development, Group IIAdam19
Mammary Neoplasms, AnimalAreg , Cdkn1a , Egfr , Erbb2 , Hras , Pik3r1 , Rasa1 , Stat3 , Stat5a
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Areg , Bad , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Gsn , Hras , Map2k7 , Mtor , Myc , Pak4 , Pik3r1 , Ptk2 , Rasa1 , Stat1 , Stat3 , Stat5a
Mandibular NeoplasmsBraf
Marijuana AbuseAkt1 , Camk2b
Maxillary Sinus NeoplasmsCdkn1a
Median NeuropathyErbb2 , Erbb3 , Erbb4 , Nrg1
Mediastinal NeoplasmsPtpn1
MedulloblastomaErbb2 , Myc , Stat3
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
MelanomaBraf , Cbl , Cdkn1a , Erbb4 , Map2k1 , Map2k2 , Nras , Pik3ca
Melanoma, Cutaneous MalignantStat3
Melanoma, Cutaneous Malignant, Susceptibility To, 1Braf , Cbl , Nras , Pik3ca
Memory DisordersAbl1 , Stat3
MeningiomaAkt1
Mental Retardation, X-LinkedPak3
Mental Retardation, X-Linked 30Pak3
Mental Retardation, X-Linked NonsyndromicPak3
Mercury Poisoning, Nervous SystemJun
Meretoja SyndromeGsn
MesotheliomaCdkn1b , Egfr , Gsn , Mtor
Mesothelioma, MalignantCdkn1a , Egfr , Raf1
MetachondromatosisPtpn11
Microphthalmia, Syndromic 1Adam17
Microsatellite InstabilityBraf
Mild Cognitive ImpairmentHsp90aa1
Mood DisordersAkt1
Mouth NeoplasmsErbb2 , Erbb3 , Hras , Kras , Nras , Pik3ca , Ptk2
Movement DisordersNrg1
MucositisTgfa
Multiple Endocrine NeoplasiaCdkn1b
Multiple Endocrine Neoplasia, Type IVCdkn1b
Multiple MyelomaCbl , Kras , Nras
Multiple Organ FailureMapk1
Multiple SclerosisCblb
Muscular AtrophyAkt1 , Gsk3b , Mtor , Rps6kb1
Muscular Dystrophy, AnimalMtor
Muscular Dystrophy, FacioscapulohumeralCdkn1a
Mycobacterial and Viral Infections, Susceptibility To, Autosomal RecessiveStat1
Mycobacterium InfectionsStat1
Mycobacterium Infections, NontuberculousStat1
Myelodysplastic SyndromesCdkn1b , Myc , Nras
Myeloproliferative DisordersCbl , Kras , Nras
Myocardial InfarctionAkt1 , Cdkn1b , Gsk3b , Mapk1 , Mtor , Nrg1 , Rps6kb1
Myocardial IschemiaAreg , Camk2d , Crk , Eif4ebp1 , Erbb2 , Stat5a
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Cbl , Gsk3b , Mapk1 , Mapk8 , Mapk9 , Prkcb , Stat1 , Stat3
Myoclonus, Familial CorticalMyc
Myopathy, Congenital, with Excess of Muscle SpindlesHras
Nasal PolypsJun , Stat3
Nasopharyngeal carcinomaAkt2 , Erbb2 , Erbb3 , Kras , Pik3ca
Nasopharyngeal NeoplasmsEgfr
Nematode InfectionsPik3r1
NeointimaErbb4 , Nrg1 , Pak1
Neoplasm InvasivenessEgfr , Hras , Mapk1 , Mapk3 , Nrg1 , Ptk2 , Src , Tln1
Neoplasm MetastasisAkt2 , Braf , Cdkn1a , Egfr , Erbb2 , Erbb3 , Hsp90aa1 , Kras , Mapk1 , Mapk3 , Mapk9 , Mtor , Myc , Ptk2 , Src , Stat3
Neoplasm Recurrence, LocalEgfr , Erbb2
NeoplasmsErbb2 , Kras , Myc
Neoplasms, ExperimentalAbl1 , Erbb2 , Hras , Kras , Nras
Neoplasms, Germ Cell and EmbryonalErbb2
Neoplastic ProcessesHras
Neoplastic Syndromes, HereditaryPik3ca
NephritisMtor , Ptk2
Nephrosis, LipoidCdkn1a
Nephrosis, Puromycin AminonucleosidePak2
Nephrotic SyndromeNck1 , Nck2
Nerve DegenerationMapk1 , Mapk3 , Tgfa
NeuroblastomaHras , Kras , Myc , Nras , Ptpn11
Neurocutaneous MelanosisNras
Neuroectodermal TumorsMyc
Neuroendocrine TumorsBraf , Cdkn1b
NeurofibrosarcomaNras
Neuroma, AcousticCdkn1a
Neurotoxicity SyndromesMtor
NevusBraf
Nevus, PigmentedNras
Nevus, Sebaceous of JadassohnHras , Kras , Nras
Niemann-Pick Disease, Type CAbl1 , Stat3
Niemann-Pick DiseasesAbl1
Non-alcoholic Fatty Liver DiseaseStat3
Nonseminomatous Germ Cell TumorBraf
Noonan like syndromeCbl , Ptpn11 , Sos1
Noonan SyndromeBraf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1
Noonan syndrome 3Kras
Noonan Syndrome 4Sos1
Noonan Syndrome 5Raf1
Noonan Syndrome 6Nras
Noonan Syndrome 7Braf
NOONAN SYNDROME 9Sos2
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaCbl
ObesityAkt1 , Akt2 , Bad , Cdkn1b , Egfr , Mtor , Myc , Pik3r1 , Prkcb , Ptpn1 , Rps6kb1 , Stat3
Obsessive-Compulsive DisorderHras
Ocular HypertensionCdkn1a
Optic Nerve InjuriesJun
Oral Squamous Cell CarcinomaCdkn1a
OsteoarthritisAdam12 , Bad , Mtor
Osteoarthritis, KneeHsp90aa1 , Tgfa
OsteochondromaPtpn11
OsteopetrosisJun
OsteoporosisAbl1 , Gsn , Myc , Tln1
OsteosarcomaEgfr , Jun , Myc
Otitis MediaBtc
Ovarian Epithelial CancerPik3ca
Ovarian NeoplasmsAkt1 , Akt2 , Areg , Braf , Cdkn1a , Cdkn1b , Crkl , Egfr , Erbb2 , Erbb3 , Erbb4 , Ereg , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk3 , Mtor , Myc , Pak1 , Pik3ca , Pik3r1 , Prkca , Ptk2 , Stat3
Oxygen-Induced RetinopathyMapk8 , Stat3
Paget's Disease, MammaryErbb2
PainAkt1 , Nrg1
Pancreatic CarcinomaCdkn1a , Kras , Mtor
Pancreatic NeoplasmsAdam9 , Akt2 , Egf , Egfr , Kras , Map2k4 , Mtor , Myc , Stat3 , Tgfa
PancreatitisEgf
Pancreatitis, ChronicBad
Pancreatitis, Experimental, Acute Cdkn1a , Kras
Papillary Renal Cell Carcinoma, SporadicMyc
PapillomaCdkn1a , Egfr , Erbb2 , Hras , Map2k4
Papilloma, InvertedCdkn1a
ParaplegiaAkt1
ParatuberculosisGsn
Parkinson DiseaseAbl1 , Akt1 , Egf , Egfr , Erbb2 , Gsk3b
Parkinsonian DisordersBad , Egfr , Mtor , Src
Penile NeoplasmsHras , Kras , Pik3ca
Peripheral Nervous System DiseasesErbb4 , Jun
PeritonitisGsk3b
Phencyclidine AbuseCamk2b
Phobic DisordersHras
Phyllodes TumorCdkn1a , Egfr , Erbb3 , Erbb4
Pituitary NeoplasmsCdkn1a , Cdkn1b , Prkca
Pleomorphic Xanthoastrocytoma Braf
PneumoniaEgf
Pneumonia, BacterialStat3
Pneumonia, PneumococcalMapk1 , Mapk3
PoisoningGsk3b
Polycystic Kidney Disease, Type 1Myc
Polycystic Kidney DiseasesMtor , Myc , Plcg1
Polycystic Kidney, Autosomal DominantCdkn1a , Mtor , Myc , Rps6kb1
Polycystic Kidney, Autosomal RecessiveAkt1 , Egfr , Mtor , Myc , Pik3ca , Src
Polycystic Ovary SyndromeCamk2d , Gab1 , Nrg1
PolymicrogyriaAkt3
PolyuriaPrkca
Port-Wine StainRasa1
Pre-EclampsiaErbb2
Precancerous ConditionsAbl1 , Hras , Map2k7 , Mapk8 , Mapk9 , Stat3 , Stat5a
Precursor B-Cell Lymphoblastic Leukemia-LymphomaAbl1 , Stat3
Precursor Cell Lymphoblastic Leukemia-LymphomaAbl1 , Kras , Myc , Nras
Precursor T-Cell Lymphoblastic Leukemia-LymphomaKras , Mtor , Ptpn11
ProlactinomaMyc
Prostatic HyperplasiaBad , Myc
Prostatic Intraepithelial NeoplasiaAreg , Cdkn1b , Kras , Map2k4 , Map2k7 , Myc
Prostatic NeoplasmsAdam9 , Akt1 , Areg , Bad , Braf , Cdkn1a , Cdkn1b , Crkl , Egfr , Erbb2 , Erbb3 , Erbb4 , Gsk3b , Jun , Kras , Map2k1 , Map2k4 , Map2k7 , Mapk10 , Mapk3 , Mtor , Myc , Nras , Pak4 , Pak6 , Pik3ca , Pik3cd , Pik3r1 , Prkca , Prkcz , Ptk2 , Src , Stat1 , Stat3 , Stat5b , Tgfa
ProteinuriaNck1 , Nck2 , Pak1
Proteus SyndromeAkt1
Protoporphyria, ErythropoieticAreg , Btc , Ereg
PsoriasisAreg , Cdkn1a , Stat3 , Tgfa
Psychoses, Substance-InducedAkt1 , Camk2b
Psychotic DisordersNrg1
Pulmonary Disease, Chronic ObstructiveEgfr , Erbb3 , Map2k4 , Mapk8
Pulmonary EdemaTgfa
Pulmonary FibrosisAreg , Bad , Egfr , Stat1 , Stat3 , Tgfa
Pulmonary Valve StenosisHras
Radiation Injuries, ExperimentalMapk1 , Mapk3
RadiculopathyErbb4
RASopathiesBraf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1
Rectal NeoplasmsCdkn1b , Egfr , Nras , Pik3ca
RecurrenceErbb2 , Erbb3 , Hras , Kras
Renal FibrosisKras , Mapk1 , Myc
Reoviridae InfectionsStat1
Reperfusion InjuryAkt1 , Bad , Cdkn1a , Cdkn1b , Egf , Hbegf , Jun , Mapk8 , Mapk9 , Pik3r1 , Prkca , Ptk2 , Src , Stat1 , Stat3 , Stat5a , Stat5b
Respiratory HypersensitivityPtpn6
Reticulate Acropigmentation of KitamuraAdam10
Retina Reperfusion InjuryBad , Map2k4 , Stat3
Retinal DegenerationPak3 , Pak4
Retinal NeovascularizationMtor
Retinitis PigmentosaAdam9 , Prkcg
Rett SyndromePtpn1
Rhabdoid TumorMyc
Salivary Gland NeoplasmsCdkn1a
SarcoidosisCdkn1a
SarcomaPik3ca
Sarcoma, ExperimentalKras , Nras
Sarcoma, MyeloidKras
SarcopeniaCdkn1a
SchizophreniaAkt1 , Camk2b , Crkl , Egf , Egfr , Elk1 , Gsk3b , Mapk3 , Mtor , Nrg1 , Nrg3 , Pak1 , Pik3cb
Sciatic NeuropathyCdkn1b , Mtor , Nrg1
Scleroderma, LocalizedCdkn1a
ScrapieStat1 , Stat3
Sebaceous Gland NeoplasmsCdkn1a
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
SeizuresBad , Camk2d , Erbb4 , Gnai1 , Nrg1
SeminomaHras , Kras
Senile CataractCdkn1b
Senior Loken SyndromeAkt3
SepsisBad , Cdkn1a , Gsk3b , Mapk1 , Mapk3 , Mtor , Stat1 , Stat3
Sepsis-Associated EncephalopathyStat3
Septic PeritonitisPik3r1
Sezary SyndromeBraf , Cdkn1b , Mapk1 , Plcg1
Shock, HemorrhagicBad , Mapk1 , Mtor , Myc
SHORT SyndromePik3r1
SilicosisPrkcb
Sinonasal NeoplasmsCdkn1a
Skin NeoplasmsAkt1 , Cdkn1a , Crkl , Erbb4 , Hras , Map2k4 , Stat3
Sleep DeprivationMap2k4
Small Cell Lung CarcinomaEgfr
Small-For-Size SyndromeBad
Smith-Kingsmore SyndromeMtor
Smith-Magenis SyndromeErbb2 , Grb2 , Prkca , Rps6kb1 , Stat3 , Stat5a , Stat5b
Spinal Cord InjuriesAkt1 , Cdkn1b , Egfr , Erbb3 , Jun , Mtor
Spinal Cord Reperfusion InjuryBad
Spinocerebellar Ataxia 14Prkcg
Spinocerebellar AtaxiasPrkcg
Splenic NeoplasmsHras
Spondylocostal Dysostosis 5Mapk3
Squamous Cell Carcinoma of the LungKras
Squamous Cell Carcinoma of the TongueCdkn1a , Egfr
Status EpilepticusAdam10 , Adam9 , Gsk3b , Jun , Mtor , Prkcb , Src
Stomach NeoplasmsAreg , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Hbegf , Hras , Jun , Kras , Mapk1 , Mapk3 , Mapk8 , Myc , Pik3ca , Prkcb , Stat3 , Tgfa
Stomach UlcerBad , Nrg1
StrokeAkt1 , Erbb4 , Mapk8 , Pak1 , Src , Tgfa
Sturge-Weber SyndromeRasa1
Subarachnoid HemorrhageStat3
Substance Withdrawal SyndromeGnai1 , Mapk1 , Mapk3
T-LymphocytopeniaStat5b
Tachycardia, VentricularRaf1
Temporomandibular Joint DisordersMtor
Testicular Germ Cell TumorHras
Testicular NeoplasmsCdkn1b
Tetralogy of FallotPtpn11
ThrombosisPik3cb
Thyroid Cancer, FollicularBraf , Hras , Nras
Thyroid Cancer, MedullaryKras
Thyroid cancer, papillaryBraf
Thyroid NeoplasmsBraf , Cdkn1a , Hras , Kras
Tobacco Use DisorderEgfr
Tongue NeoplasmsCdkn1a , Hras , Stat3
Transplant RejectionMyc
Trauma, Nervous SystemStat1
Trichilemmoma Hras
Trigeminal NeuralgiaMapk1 , Mapk3 , Mapk8 , Mapk9 , Prkcg
Tuberculosis, PulmonaryJun
Tuberous SclerosisEif4ebp1
UremiaPtk2
Ureteral ObstructionAbl1 , Akt1 , Mtor , Pak2
Urethral ObstructionMapk1
Urinary Bladder NeoplasmsAkt1 , Areg , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Hras , Kras , Map2k4 , Mtor , Myc , Prkca , Src
Urinary Bladder, OveractiveNrg1
Urinary IncontinenceMapk1
Urologic NeoplasmsErbb2
Uterine Cervical NeoplasmsAdam9 , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Hras , Kras , Mtor , Myc , Nras , Ptk2 , Stat3
Uterine NeoplasmsCdkn1b , Kras
Uveitis, Autoimmune, ExperimentalStat3
Uveoretinitis, Autoimmune, ExperimentalStat3
VasculitisCbl
Ventilator-Induced Lung InjuryAkt1
Wallerian DegenerationErbb2 , Erbb3
Weight GainGsn , Pik3ca
Wet Macular DegenerationMapk8
Wilms TumorCdkn1b , Erbb2 , Myc , Pak1 , Stat1 , Stat3
Wounds and InjuriesEgf
Zollinger-Ellison SyndromeEgf
Pathway Annotations Associated with Genes in the epidermal growth factor/neuregulin signaling pathway
Pathway TermsGene Symbols
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein familyGnai1
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Eif4ebp1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rps6kb1 , Rps6kb2 , Sos1 , Sos2 , Stat3 , Stat5a , Stat5b
adenosine signaling pathwayAkt1 , Bad , Braf , Elk1 , Hras , Jun , Map2k2 , Map2k7 , Mapk1 , Mapk8 , Pak1 , Pik3ca , Prkcz
aldosterone signaling pathwayHsp90aa1 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2 , Tgfa
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
altered Reelin signaling pathwaySrc
Alzheimer disease pathwayAdam10 , Adam17 , Bad , Gsk3b , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayBad
androgen signaling pathwayHsp90aa1
angiotensin II signaling pathwayPrkcz
angiotensin II signaling pathway via AT2 receptorErbb3 , Gnai3 , Ptpn6
antigen processing and presentation pathwayHsp90aa1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Gsk3b , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg2 , Prkcb , Ptpn6 , Raf1 , Sos1 , Sos2
basal cell carcinoma pathwayGsk3b
bladder cancer pathwayBraf , Cdkn1a , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Raf1
Bone morphogenetic proteins signaling pathwayGsk3b , Mapk1
brain-derived neurotrophic factor signaling pathwayGrb2 , Shc1
c-Jun N-terminal kinases MAPK signaling pathwayMap2k4 , Map2k7 , Mapk10 , Mapk8 , Mapk9
calcium/calcium-mediated signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g , Egfr , Erbb2 , Erbb3 , Erbb4 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg
calcium/calmodulin dependent kinase 2 signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g
cell cycle pathway, mitoticAbl1 , Cdkn1a , Cdkn1b , Gsk3b , Myc
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Kras , Map2k1 , Map2k2 , Map2k4 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcz , Raf1 , Stat1 , Stat3 , Tgfa
cetuximab pharmacodynamics pathwayEgfr
chaperone mediated autophagy pathwayHsp90aa1
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Gnai1 , Gnai3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcb , Prkcz , Ptk2 , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2 , Stat1 , Stat3 , Stat5b , Wasl
chronic myeloid leukemia pathwayAbl1 , Akt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Cblb , Cblc , Cdkn1a , Cdkn1b , Crk , Crkl , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2 , Stat5a , Stat5b
clathrin-dependent synaptic vesicle endocytosisPip5k1c
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Gsk3b , Jun , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
cortisol signaling pathwayHsp90aa1
cytokine mediated signaling pathwayEgf , Egfr
dopamine signaling pathwaySrc
E-cadherin signaling pathwayAkt1 , Akt2 , Crk , Egf , Egfr , Nck1 , Pik3ca , Pik3r1 , Pip5k1c , Plcg1 , Src
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5 , Prkca , Prkcg , Prkcz , Src
endocytosis pathwayCbl , Cblb , Cblc , Egf , Egfr , Erbb3 , Erbb4 , Hras , Pip5k1c , Prkcz , Src
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Elk1 , Erbb2 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Endoplasmic Reticulum-associated degradation pathwayHsp90aa1 , Map2k7 , Mapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Crk , Gnai1 , Gnai3 , Hras , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapk8 , Prkca , Prkcg , Raf1 , Src
Entamoeba histolyca infection pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Ptk2
ephrin - ephrin receptor bidirectional signaling axisCbl , Crk , Crkl , Grb2 , Hras , Map2k1 , Map2k4 , Mapk1 , Mapk3 , Mapk8 , Nck1 , Nck2 , Nras , Pak1 , Pik3ca , Pik3r1 , Pik3r5 , Plcg1 , Rasa1 , Src , Wasl
epidermal growth factor/neuregulin signaling pathwayAbl1 , Abl2 , Adam10 , Adam12 , Adam17 , Adam19 , Adam9 , Akt1 , Akt2 , Akt3 , Areg , Bad , Braf , Btc , Camk2a , Camk2b , Camk2d , Camk2g , Cbl , Cblb , Cblc , Cdkn1a , Cdkn1b , Crk , Crkl , Egf , Egfr , Eif4ebp1 , Elk1 , Epgn , Erbb2 , Erbb3 , Erbb4 , Ereg , Gab1 , Gnai1 , Gnai3 , Grb2 , Gsk3b , Gsn , Hbegf , Hras , Hsp90aa1 , Jun , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Myc , Nck1 , Nck2 , Nras , Nrg1 , Nrg2 , Nrg3 , Nrg4 , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pip5k1c , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Prkcz , Ptk2 , Ptpn1 , Ptpn11 , Ptpn6 , Ptprj , Raf1 , Rasa1 , Rps6kb1 , Rps6kb2 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2 , Src , Stat1 , Stat3 , Stat5a , Stat5b , Tgfa , Tln1 , Wasl
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayCbl , Crkl , Gab1 , Grb2 , Hras , Mapk8 , Pik3r1 , Plcg1 , Plcg2 , Ptpn11 , Ptpn6 , Shc1 , Sos1 , Stat1 , Stat5a , Stat5b
estrogen signaling pathwayHsp90aa1 , Src
FasL mediated signaling pathwayAkt1 , Map2k7 , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcg , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Crk , Crkl , Gsn , Map2k1 , Mapk1 , Mapk3 , Pak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pip5k1c , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1 , Rps6kb1 , Rps6kb2 , Wasl
fibroblast growth factor signaling pathwayAkt1 , Camk2a , Cbl , Gab1 , Grb2 , Jun , Mapk1 , Mapk3 , Pak4 , Pik3ca , Pik3r1 , Plcg1 , Ptpn11 , Shc1 , Sos1 , Src , Stat1 , Stat5b
forkhead class A signaling pathwayAkt1 , Cdkn1b , Jun
G protein mediated signaling pathway via Galphai familyGnai1 , Gnai3
G1/S transition pathwayCdkn1a , Cdkn1b
gefitinib pharmacodynamics pathwayEgfr
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Camk2a , Camk2b , Camk2d , Camk2g , Cdkn1a , Egf , Egfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2 , Tgfa
glutamate signaling pathwayGnai1 , Gnai3 , Mapk1 , Mapk3 , Prkca , Prkcb , Prkcg
glycogen biosynthetic pathwayGsk3b
glypican signaling pathwayMapk8 , Mapk9 , Nrg1 , Src
gonadotropin-releasing hormone signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g , Egfr , Elk1 , Grb2 , Hbegf , Hras , Jun , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Prkca , Prkcb , Raf1 , Sos1 , Sos2 , Src
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Ptpn11 , Raf1 , Shc1 , Sos1 , Stat1 , Stat3 , Stat5a , Stat5b
Hedgehog signaling pathwayAkt1 , Gnai1 , Gnai3 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdkn1a , Egf , Egfr , Grb2 , Gsk3b , Hras , Kras , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Stat1 , Stat3
hypoxia inducible factor pathwayAkt1 , Elk1 , Jun
inflammatory response pathwayMapk8
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Gsk3b , Jun , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Raf1 , Stat1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Pip5k1c , Plcg1 , Plcg2
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Cbl , Crk , Gsk3b , Pak1 , Prkcz
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Cblb , Cblc , Crk , Crkl , Eif4ebp1 , Elk1 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Nck1 , Nck2 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Prkcz , Ptpn1 , Ptpn11 , Raf1 , Rasa1 , Rps6kb1 , Rps6kb2 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Bad , Crk , Crkl , Grb2 , Hras , Nck2 , Pik3ca , Pik3r1 , Prkcz , Ptpn1 , Ptpn11 , Raf1 , Rps6kb1 , Shc1 , Sos1
integrin mediated signaling pathwayNck2 , Ptk2 , Tln1
interleukin-1 signaling pathwayJun , Mapk8 , Pik3ca , Pik3r1 , Prkcz
Interleukin-10 signaling pathwayStat1 , Stat3
interleukin-12 signaling pathwayMtor , Stat1 , Stat3 , Stat5a
interleukin-2 signaling pathwayGrb2 , Hras , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Myc , Nras , Pik3ca , Pik3r1 , Prkcb , Ptpn11 , Raf1 , Rasa1 , Shc1 , Sos1 , Stat1 , Stat3 , Stat5a , Stat5b
interleukin-23 signaling pathwayPik3ca , Pik3r1 , Stat1 , Stat3 , Stat5a
interleukin-27 signaling pathwayStat1 , Stat3 , Stat5a
interleukin-3 signaling pathwayGrb2 , Pik3ca , Pik3r1 , Ptpn11 , Shc1 , Stat5a , Stat5b
interleukin-4 signaling pathwayAkt1 , Cbl , Grb2 , Mtor , Pik3ca , Pik3r1 , Ptpn6 , Rps6kb1 , Shc1 , Stat5a , Stat5b
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1 , Ptpn11 , Stat5a , Stat5b
interleukin-6 signaling pathwayAdam10 , Adam17 , Akt1 , Gab1 , Grb2 , Jun , Map2k4 , Myc , Pik3ca , Pik3r1 , Ptpn11 , Sos1 , Sos2 , Stat1 , Stat3
intrinsic apoptotic pathwayBad
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn1 , Ptpn11 , Ptpn6 , Sos1 , Sos2 , Stat1 , Stat3 , Stat5a , Stat5b
Leishmania infection pathwayElk1 , Jun , Mapk1 , Mapk3 , Prkcb , Ptpn6 , Stat1
leptin system pathwayPtpn1 , Ptpn11 , Stat3
long term depressionBraf , Gnai1 , Gnai3 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Raf1
long term potentiationBraf , Camk2a , Camk2b , Camk2d , Camk2g , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Ptk2 , Raf1
measles infection pathwayAkt1 , Akt2 , Akt3 , Cblb , Cdkn1b , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3 , Stat5a , Stat5b
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdkn1a , Egf , Egfr , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
mitochondrial autophagy pathwaySrc
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Egf , Egfr , Elk1 , Erbb2 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Nras , Pak1 , Pak2 , Prkca , Prkcb , Prkcg , Raf1 , Rasa1 , Shc1 , Sos1 , Sos2
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Eif4ebp1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Raf1 , Rps6kb1 , Rps6kb2
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Camk2a , Camk2b , Camk2d , Camk2g , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Raf1 , Src , Stat1
myocarditis pathwayAbl1 , Abl2
N-cadherin signaling pathwayCamk2g , Gsn , Mapk8 , Pik3ca , Pik3r1 , Pip5k1c , Plcg1 , Ptpn1 , Ptpn11
nerve growth factor signaling pathwaySos1 , Src
neurotrophic factor signaling pathwayAbl1 , Akt1 , Akt2 , Akt3 , Bad , Braf , Camk2a , Camk2b , Camk2d , Camk2g , Crk , Crkl , Gab1 , Grb2 , Gsk3b , Hras , Jun , Kras , Map2k1 , Map2k2 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Ptpn11 , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
NOD-like receptor signaling pathwayHsp90aa1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1 , Sos1 , Sos2 , Tgfa
Notch signaling pathwayAdam10 , Adam12 , Adam17 , Cbl , Cdkn1a , Myc
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1 , Prkca , Src
nuclear factor, erythroid 2 like 2 signaling pathwayCdkn1a , Gsk3b
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2Gnai1
p38 MAPK signaling pathwayCamk2b
p53 signaling pathwayAbl1 , Akt1 , Cdkn1a , Gsk3b , Mapk8 , Mapk9
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Stat1 , Stat3 , Tgfa
panitumumab pharmacodynamics pathwayEgfr
phosphatidylinositol 3-kinase class I signaling pathwayHras , Hsp90aa1 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Src
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pip5k1c , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Cdkn1b , Gsk3b , Hsp90aa1 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1 , Src
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1
platelet-derived growth factor signaling pathwayAbl1 , Braf , Cbl , Crk , Crkl , Elk1 , Gab1 , Grb2 , Hras , Jun , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Nck1 , Nck2 , Nras , Pak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Prkca , Ptpn1 , Ptpn11 , Ptprj , Raf1 , Rasa1 , Shc1 , Sos1 , Src , Stat1 , Stat3 , Stat5a , Stat5b , Wasl
prednisolone pharmacodynamics pathwayHsp90aa1
prednisolone pharmacokinetics pathwayHsp90aa1
prion diseases pathwayElk1 , Map2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdkn1a , Cdkn1b , Egf , Egfr , Erbb2 , Grb2 , Gsk3b , Hras , Hsp90aa1 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
protein kinase C (PKC) signaling pathwayHsp90aa1 , Prkca , Prkcb , Prkcg , Prkcz , Rasa1
pyruvate metabolic pathwayPdk1
Ras family mediated signaling pathwaySos1
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Cbl , Crkl , Gsk3b , Map2k7 , Mapk8 , Nck2 , Pik3ca , Pik3r1 , Src
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Gab1 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Sos1 , Sos2 , Tgfa
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMapk10 , Mapk8 , Mapk9
rheumatoid arthritis disease pathwayJun
Rho/Rac/Cdc42 mediated signaling pathwayCbl , Crk , Jun , Map2k4 , Mapk8 , Pak1
ribosome biogenesis pathwayPrkcb
RNA transport pathwayEif4ebp1
scatter factor/hepatocyte growth factor signaling pathwayCbl , Crkl , Gab1 , Grb2 , Pik3r1 , Plcg1 , Ptpn11 , Shc1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Cdkn1b , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptk2
somatostatin signaling pathwayPtpn11 , Ptprj , Src
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Elk1 , Gnai1 , Gnai3 , Jun , Mapk1 , Mapk3 , Mapk8 , Pak1 , Plcg1 , Src
syndecan signaling pathwayAdam12 , Egfr , Hras , Mapk1 , Mapk3 , Mapk8 , Prkca , Rasa1 , Src
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Gsk3b , Hras , Jun , Kras , Map2k1 , Map2k2 , Map2k7 , Mapk1 , Mapk3 , Mapk9 , Nck1 , Nck2 , Nras , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Ptpn6 , Raf1 , Sos1 , Sos2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
thyroid cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Jun , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Gnai1 , Gnai3 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3
Trail mediated signaling pathwayMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayCamk2a , Grb2 , Rps6kb1 , Shc1 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Myc , Rps6kb1 , Rps6kb2
trastuzumab pharmacodynamics pathwayEgfr
Trypanosoma brucei infection pathwayPrkca , Prkcb , Prkcg
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Gnai1 , Gnai3 , Jun , Map2k4 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
tumor necrosis factor mediated signaling pathwayAdam17 , Map2k7 , Prkcz , Stat1
type 2 diabetes mellitus pathwayAkt2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcz
type II interferon signaling pathwayAkt1 , Camk2a , Camk2b , Camk2d , Camk2g , Cbl , Crkl , Map2k1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1 , Ptpn11 , Stat1 , Stat3
ubiquitin/proteasome degradation pathwayCbl , Cblb , Cblc , Src
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Gab1 , Grb2 , Hras , Hsp90aa1 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nck1 , Nck2 , Nras , Pak2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Prkcz , Ptk2 , Ptpn11 , Ptpn6 , Ptprj , Raf1 , Shc2 , Src
vinblastine pharmacodynamics pathwayCdkn1a
vincristine pharmacodynamics pathwayCdkn1a
vindesine pharmacodynamics pathwayCdkn1a
vinorelbine pharmacodynamics pathwayCdkn1a
Wnt signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g , Gsk3b , Jun , Mapk10 , Mapk8 , Mapk9 , Myc , Prkca , Prkcb , Prkcg
Wnt signaling, canonical pathwayGsk3b
Wnt signaling, non-canonical pathwayCamk2a , Mapk10 , Mapk8 , Mapk9 , Prkcz
Phenotype Annotations Associated with Genes in the epidermal growth factor/neuregulin signaling pathway

References Associated with the epidermal growth factor/neuregulin signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: