INSULIN SIGNALING PATHWAY (PW:0000143)

View Ontology Report

Description

Insulin signaling pathway plays essential roles in glucose and energy homeostasis. Impairment of the pathway, such as decrease in insulin signaling can lead to insulin resistance, the risk of developing type-2 diabetes (T2D) and the complications associated with it. Insulin binding to its receptor InsR, the only receptor of the insulin pathway, results in conformational changes and subsequent autophosphorylation of distinct tyrosine residues on the juxtamembrane, kinase and C-terminal doma

Pathway Diagram:

Ariadne Genomics Inc. Irs1 Sh2b2 PY_multiple PY972 Socs1 Socs3 Socs6 Socs7 Insr --+> Shc1 Insr --+> Irs2 Shc1 Grb2 ---- Irs1 Grb2 Sos2 Sos1 Irs2 Socs7 ---| Insr Socs3 ---| Insr Socs6 ---| Insr Socs1 ---| Insr Grb2 ---- Sos1 insulin responsive facilitative sugar transporter mediated glucose transport pathway Ins2 ---- Insr Grb10 Grb14 Insr --+> Irs3 Irs3 Insr Insr --+> Irs4 Irs4 Pkcs Insr --+> Irs1 Ptpn1 Enpp1 Ptprf phosphatidylinositol 3-kinase-Akt signaling pathway Insr --+> insulin responsive facilitative sugar transporter mediated glucose transport pathway Insr --+> Sh2b2 the extracellular signal-regulated Raf/Mek/Erk signaling pathway Ptpn11 Ins2 Ptpn1 ---| Insr Ptprf ---| Insr Grb2 ---- Shc1 Grb2 ---- Sos2 Irs2 ---- Ptpn11 Grb2 ---- Irs2 Pik3r1 Pkcs ---| Irs1 Pkcs ---| Insr Enpp1 ---| Insr Grb10 ---| Insr Grb14 ---| Insr Irs2 ---- Pik3r1 Irs1 ---- Pik3r1 Ins1 ---- Insr Ins1 Irs2 --+> phosphatidylinositol 3-kinase-Akt signaling pathway Irs1 --+> phosphatidylinositol 3-kinase-Akt signaling pathway Ptpn11 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos1 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway
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Genes in Pathway:

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insulin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaca acetyl-CoA carboxylase alpha JBrowse link 10 71,519,392 71,719,910 RGD:6907045
G Acacb acetyl-CoA carboxylase beta JBrowse link 12 48,127,149 48,238,969 RGD:6907045
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
RGD:6907045
RGD:10402751
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6484113
RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:6907045
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:6907045
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:6907045
G Calml3 calmodulin-like 3 JBrowse link 17 70,070,458 70,073,697 RGD:6907045
G Calml5 calmodulin-like 5 JBrowse link 17 70,044,956 70,045,886 RGD:6907045
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6484113
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:6484113
RGD:6907045
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:6907045
G Cblc Cbl proto-oncogene C JBrowse link 1 80,699,321 80,716,146 RGD:6907045
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:6907045
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:6907045
G Dok1 docking protein 1 JBrowse link 4 113,864,211 113,866,695 RGD:6484113
G Eif4e eukaryotic translation initiation factor 4E JBrowse link 2 243,819,616 243,853,987 RGD:6907045
G Eif4e2 eukaryotic translation initiation factor 4E family member 2 JBrowse link 9 94,310,476 94,325,445 RGD:6907045
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:6484113
RGD:6907045
G Elk1 ELK1, ETS transcription factor JBrowse link X 1,287,875 1,304,822 RGD:6907045
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 JBrowse link 1 21,748,201 21,813,205 RGD:1625124
G Exoc2 exocyst complex component 2 JBrowse link 17 34,665,810 34,842,266 RGD:6484113
G Exoc3 exocyst complex component 3 JBrowse link 1 31,700,953 31,731,726 RGD:6484113
G Exoc4 exocyst complex component 4 JBrowse link 4 60,549,128 61,358,305 RGD:6484113
G Exoc5 exocyst complex component 5 JBrowse link 15 25,888,757 25,933,302 RGD:6484113
G Exoc6 exocyst complex component 6 JBrowse link 1 256,211,879 256,369,318 RGD:6484113
G Exoc7 exocyst complex component 7 JBrowse link 10 105,242,152 105,259,795 RGD:6484113
RGD:6907045
G F2rl2 coagulation factor II (thrombin) receptor-like 2 JBrowse link 2 26,240,385 26,245,533 RGD:6484113
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6907045
G Fbp1 fructose-bisphosphatase 1 JBrowse link 17 396,175 417,480 RGD:6907045
G Fbp2 fructose-bisphosphatase 2 JBrowse link 17 372,554 389,918 RGD:6907045
G Flot1 flotillin 1 JBrowse link 20 3,427,890 3,438,418 RGD:6907045
G Flot2 flotillin 2 JBrowse link 10 65,304,901 65,329,332 RGD:6907045
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:6907045
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6484113
G G6pc glucose-6-phosphatase, catalytic subunit JBrowse link 10 89,286,009 89,296,213 RGD:6907045
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:6907045
G Grb10 growth factor receptor bound protein 10 JBrowse link 14 92,021,851 92,122,249 RGD:1625124
RGD:6484113
G Grb14 growth factor receptor bound protein 14 JBrowse link 3 50,937,403 51,054,447 RGD:61620
RGD:1625124
RGD:6484113
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:1299201
RGD:6484113
RGD:6907045
RGD:10402751
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6907045
G Gys1 glycogen synthase 1 JBrowse link 1 101,427,195 101,447,092 RGD:6907045
G Gys2 glycogen synthase 2 JBrowse link 4 176,638,632 176,679,805 RGD:6907045
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:6907045
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6907045
G Hk3 hexokinase 3 JBrowse link 17 10,134,726 10,152,976 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6484113
RGD:6907045
RGD:10402751
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Inpp5d inositol polyphosphate-5-phosphatase D JBrowse link 9 94,745,220 94,850,778 RGD:6484113
RGD:6907045
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:1625124
RGD:6907045
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:1625124
RGD:6484113
RGD:6907045
RGD:10402751
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:1299201
RGD:1580595
RGD:1625124
RGD:6484113
RGD:6907045
RGD:10402751
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:1580595
RGD:1581310
RGD:6484113
RGD:6907045
RGD:7248547
RGD:10402751
G Irs2 insulin receptor substrate 2 JBrowse link 16 83,824,515 83,848,569 RGD:1299201
RGD:1580595
RGD:6907045
RGD:7248547
RGD:10402751
G Irs3 insulin receptor substrate 3 JBrowse link 12 22,120,305 22,125,103 RGD:1581310
RGD:6907045
RGD:7248547
G Irs4 insulin receptor substrate 4 JBrowse link X 113,003,824 113,018,088 RGD:6907045
RGD:7248547
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Lipe lipase E, hormone sensitive type JBrowse link 1 82,248,031 82,266,727 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
RGD:10402751
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
RGD:10402751
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
RGD:10402751
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Mknk1 MAP kinase-interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:6907045
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 JBrowse link 7 11,908,107 11,919,161 RGD:6907045
G Mtor mechanistic target of rapamycin JBrowse link 5 165,263,813 165,373,967 RGD:6907045
G Nck1 NCK adaptor protein 1 JBrowse link 8 108,787,797 108,847,779 RGD:6484113
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:6484113
G Nras neuroblastoma RAS viral oncogene homolog JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pard6a par-6 family cell polarity regulator alpha JBrowse link 19 37,668,133 37,670,450 RGD:6484113
G Pck1 phosphoenolpyruvate carboxykinase 1 JBrowse link 3 171,213,936 171,219,885 RGD:6907045
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) JBrowse link 15 34,216,735 34,224,357 RGD:6907045
G Pde3a phosphodiesterase 3A JBrowse link 4 175,431,904 175,703,844 RGD:6907045
G Pde3b phosphodiesterase 3B JBrowse link 1 183,892,841 184,078,071 RGD:6907045
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6484113
RGD:6907045
RGD:10402751
G Phka1 phosphorylase kinase, alpha 1 JBrowse link X 72,377,020 72,515,385 RGD:6907045
G Phka2 phosphorylase kinase, alpha 2 JBrowse link X 35,970,650 36,926,616 RGD:6907045
G Phkb phosphorylase kinase regulatory subunit beta JBrowse link 19 22,031,684 22,281,788 RGD:6907045
G Phkg1 phosphorylase kinase, gamma 1 JBrowse link 12 30,450,431 30,464,314 RGD:6907045
G Phkg2 phosphorylase kinase catalytic subunit gamma 2 JBrowse link 1 199,019,298 199,032,053 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma JBrowse link 6 51,465,696 51,501,234 RGD:10402751
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:1299201
RGD:6484113
RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 JBrowse link 10 55,085,269 55,135,069 RGD:10402751
G Pklr pyruvate kinase, liver and RBC JBrowse link 2 188,449,158 188,458,034 RGD:6907045
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6907045
G Ppp1ca protein phosphatase 1 catalytic subunit alpha JBrowse link 1 219,439,953 219,443,570 RGD:6907045
G Ppp1cb protein phosphatase 1 catalytic subunit beta JBrowse link 6 23,548,507 23,581,136 RGD:6907045
G Ppp1cc protein phosphatase 1 catalytic subunit gamma JBrowse link 12 39,864,302 39,882,030 RGD:6907045
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A JBrowse link 4 41,171,486 41,212,116 RGD:6907045
G Ppp1r3b protein phosphatase 1, regulatory subunit 3B JBrowse link 16 60,415,192 60,427,498 RGD:6907045
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C JBrowse link 1 255,371,830 255,376,833 RGD:6907045
G Ppp1r3d protein phosphatase 1, regulatory subunit 3D JBrowse link 3 173,950,613 173,953,684 RGD:6907045
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6907045
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:6907045
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 JBrowse link 12 46,316,298 46,326,789 RGD:6907045
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 JBrowse link 2 199,831,990 199,847,623 RGD:6907045
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6907045
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:6907045
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 JBrowse link 7 140,489,499 140,506,925 RGD:6907045
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 JBrowse link 4 6,559,153 6,799,888 RGD:6907045
G Prkag3 protein kinase AMP-activated non-catalytic subunit gamma 3 JBrowse link 9 81,999,368 82,008,620 RGD:6907045
G Prkar1a protein kinase cAMP-dependent type 1 regulatory subunit alpha JBrowse link 10 97,940,705 97,959,199 RGD:6907045
G Prkar2a protein kinase cAMP-dependent type 2 regulatory subunit alpha JBrowse link 8 117,486,085 117,548,768 RGD:6907045
G Prkar2b protein kinase cAMP-dependent type 2 regulatory subunit beta JBrowse link 6 51,265,509 51,356,383 RGD:6907045
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:1625124
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:1625124
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:1625124
G Prkci protein kinase C, iota JBrowse link 2 115,941,998 116,002,550 RGD:6484113
RGD:6907045
G Prkcq protein kinase C, theta JBrowse link 17 70,971,915 71,105,286 RGD:1625124
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6484113
RGD:6907045
G Prkx protein kinase, X-linked JBrowse link X 45,080,963 45,125,095 RGD:6907045
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1580595
RGD:1625124
RGD:2293185
RGD:6484113
RGD:6907045
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:1299201
RGD:2293185
RGD:6484113
G Ptpra protein tyrosine phosphatase, receptor type, A JBrowse link 3 122,976,066 123,084,585 RGD:6484113
G Ptprf protein tyrosine phosphatase, receptor type, F JBrowse link 5 137,036,936 137,112,930 RGD:1625124
RGD:2293185
RGD:6907045
G Pygb glycogen phosphorylase B JBrowse link 3 146,581,063 146,629,504 RGD:6907045
G Pygl glycogen phosphorylase L JBrowse link 6 92,597,759 92,643,734 RGD:6907045
G Pygm glycogen phosphorylase, muscle associated JBrowse link 1 221,756,325 221,771,142 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
RGD:10402751
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:6907045
G Rasa1 RAS p21 protein activator 1 JBrowse link 2 13,617,021 13,696,531 RGD:6484113
G Rheb Ras homolog enriched in brain JBrowse link 4 6,827,429 6,873,384 RGD:6907045
G Rhoq ras homolog family member Q JBrowse link 6 10,533,151 10,568,582 RGD:6484113
RGD:6907045
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:6907045
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6484113
RGD:6907045
G Rps6kb2 ribosomal protein S6 kinase B2 JBrowse link 1 219,406,201 219,412,888 RGD:6907045
G Rptor regulatory associated protein of MTOR, complex 1 JBrowse link 10 108,750,620 109,058,691 RGD:6907045
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 24,185,451 24,302,309 RGD:6484113
G Sh2b2 SH2B adaptor protein 2 JBrowse link 12 23,471,477 23,501,043 RGD:1625124
RGD:6484113
RGD:6907045
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:1625124
RGD:6484113
RGD:6907045
RGD:10402751
G Shc2 SHC adaptor protein 2 JBrowse link 7 12,948,952 12,971,174 RGD:6907045
G Shc3 SHC adaptor protein 3 JBrowse link 17 13,670,520 13,791,043 RGD:6907045
G Shc4 SHC adaptor protein 4 JBrowse link 3 117,897,738 117,990,289 RGD:6907045
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6907045
RGD:10402751
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:1625125
RGD:6907045
G Socs2 suppressor of cytokine signaling 2 JBrowse link 7 36,495,496 36,500,878 RGD:6907045
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:1625125
RGD:6907045
G Socs4 suppressor of cytokine signaling 4 JBrowse link 15 24,056,383 24,070,868 RGD:6907045
G Socs6 suppressor of cytokine signaling 6 JBrowse link 18 85,962,729 85,981,125 RGD:1625125
G Socs7 suppressor of cytokine signaling 7 JBrowse link 10 85,301,797 85,337,971 RGD:1625125
G Sorbs1 sorbin and SH3 domain containing 1 JBrowse link 1 259,373,921 259,502,108 RGD:6484113
RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:1299201
RGD:6484113
RGD:6907045
RGD:10402751
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:1299201
RGD:6907045
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6907045
G Trip10 thyroid hormone receptor interactor 10 JBrowse link 9 9,689,214 9,702,353 RGD:6484113
RGD:6907045
G Tsc1 tuberous sclerosis 1 JBrowse link 3 7,219,955 7,269,063 RGD:6907045
G Tsc2 tuberous sclerosis 2 JBrowse link 10 13,962,006 13,996,684 RGD:6907045
altered insulin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:2313694
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:2313694

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwayinsulin responsive facilitative sugar transporter mediated glucose transport pathwaySlc2a4 (Glut4) mediated uptake of glucose
Pathwaythe extracellular signal-regulated Raf/Mek/Erk signaling pathwaythe mitogen activated protein kinase (MAPK) cascade activated by insulin signaling
Pathwayphosphatidylinositol 3-kinase-Akt signaling pathwaythe PI3K, mostly the class IA lipid kinase acting downstream of receptor tyrosine kinases

Pathway Gene Annotations

Disease Annotations Associated with Genes in the insulin signaling pathway
Disease TermsGene Symbols
2-HydroxyglutaricaciduriaSos2
Abdominal Obesity Metabolic SyndromePpargc1a
Abdominal Obesity-Metabolic Syndrome 4Lipe
Abnormalities, MultipleGsk3b , Kras , Mapk1 , Phka2
Acetyl-Coa Carboxylase DeficiencyAcaca
AcrodysostosisPrkar1a
Acrodysostosis 1, with or without Hormone ResistancePrkar1a
Activated PI3K-delta SyndromePik3cd
Acute Coronary SyndromeFasn
Acute Kidney InjuryBad , Gsk3b , Ins2 , Mtor , Ppargc1a
Acute Lung InjuryCav1 , Pik3cg , Prkaa1
AdenocarcinomaKras , Mtor , Pik3ca , Ptpn11
Adenocarcinoma of EsophagusPik3ca
Adenocarcinoma of LungBraf , Foxo3 , Hras , Kras , Map2k1 , Pik3ca , Rasa1 , Sos1
Adenocarcinoma, Bronchiolo-AlveolarKras
Adenocarcinoma, FollicularKras
AdenomaIns2 , Kras
Adenoma, Liver CellHras , Kras
Adenomatous Polyposis ColiAkt1
Adenosine Triphosphate, Elevated, of ErythrocytesPklr
Adrenal Cortex NeoplasmsPrkar1a
Adrenal Gland NeoplasmsPrkaca
Adrenal Hyperplasia, CongenitalPrkar1a
Adrenocortical CarcinomaBraf
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Aging, PrematureFoxo1
AIDS Dementia ComplexInsr , Irs1
AIDS-Associated NephropathyMtor
AlbuminuriaIns2 , Nck1 , Nck2 , Ppargc1a
Alzheimer DiseaseAkt1 , Bad , Calm1 , Elk1 , Foxo3 , Gsk3b , Hras , Ikbkb , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Mapk10 , Mapk8 , Mapk9 , Pck1 , Pik3cg , Pik3r1 , Ppargc1a , Shc1 , Slc2a4 , Tsc2
AmblyopiaPpargc1a
AmeloblastomaBraf
Amelogenesis Imperfecta NephrocalcinosisPrkar1a
Amphetamine-Related DisordersAkt1
Amyotrophic Lateral SclerosisAkt1 , Gsk3b , Ppargc1a
Amyotrophic Lateral Sclerosis 1Shc1
AnemiaHk1
Anemia, Hemolytic, Congenital NonspherocyticHk1 , Pklr
Anemia, Sickle CellHk1
Angina, UnstableAkt1
AngiomyolipomaMtor , Tsc2
AnoxiaPck2
Anti-Glomerular Basement Membrane DiseaseMapk8 , Rapgef1
Aortic Aneurysm, AbdominalCav1 , Gys1 , Mapk8
Aortic Valve InsufficiencyPtpn11
Aortic Valve StenosisPtpn11
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arterial Calcification of InfancyEnpp1
ArteriosclerosisLipe , Mapk9
Arteriovenous MalformationsRasa1
Arthritis, ExperimentalAkt1 , Cbl , Cblb , Gsk3b , Ikbkb , Mtor , Nras , Pik3cd , Pik3cg , Socs3
Arthritis, JuvenileKras , Mapk1
Arthritis, RheumatoidFoxo3 , Prkcq
AsthmaPik3cg
AstrocytomaAkt1 , Braf , Kras , Ptpn11
Ataxia-Oculomotor Apraxia 3Pik3r5
AtherosclerosisAkt1 , Cav1 , Pik3cg , Socs3
Atrial FibrillationCav1
Atrial Myxoma, FamilialPrkar1a
AtrophyMapk3 , Rps6kb1
Autism Spectrum DisorderAcaca , Mapk3 , Prkab2 , Tsc1 , Tsc2
Autistic DisorderEif4e , Hras , Pik3cg , Prkcb , Tsc1 , Tsc2
Autoimmune Lymphoproliferative SyndromeNras
Autoimmune Lymphoproliferative Syndrome, Type IVKras , Nras
Bardet-Biedl SyndromeAkt3
Benign Skin NeoplasmsHras
Biliary Tract NeoplasmsPrkacb
Bipolar DisorderAkt1 , Gsk3b , Ins2
Body Mass Index Quantitative Trait Locus 10Enpp1
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 11Enpp1
Body Mass Index Quantitative Trait Locus 12Enpp1
Body Mass Index Quantitative Trait Locus 14Enpp1
Body Mass Index Quantitative Trait Locus 4Enpp1
Body Mass Index Quantitative Trait Locus 7Enpp1
Body Mass Index Quantitative Trait Locus 8Enpp1
Body Mass Index Quantitative Trait Locus 9Enpp1
Bowen's DiseasePpargc1a
Brachydactyly with HypertensionPde3a
Brain DiseasesTsc1 , Tsc2
Brain InjuriesAkt1 , Bad , Elk1 , Gsk3b , Ppargc1a
Brain IschemiaAkt1 , Bad , Cav1 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Prkaca , Prkacb , Prkca
Breast AdenocarcinomaAkt1 , Kras , Pik3ca
Breast Cancer, FamilialPik3r3
Breast NeoplasmsAkt1 , Akt2 , Bad , Cav1 , Crkl , Fasn , Hras , Ikbkb , Insr , Kras , Map2k1 , Map2k2 , Mapk1 , Pdpk1 , Pik3ca , Pik3r1 , Prkaa1 , Prkca , Prkci , Raf1 , Rps6 , Rps6kb2 , Socs1 , Socs2 , Tsc1 , Tsc2
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Akt1 , Pik3ca
BREASTS AND/OR NIPPLES, APLASIA OR HYPOPLASIA OF, 2Ptprf
Burkitt LymphomaPik3r1
BurnsBad , Gsk3b , Mtor , Pklr , Rps6kb1 , Socs3
Cafe au lait Spots, MultipleSos1
CalcinosisEnpp1
Capillary Malformation-Arteriovenous MalformationRasa1
Carbohydrate Metabolism, Inborn ErrorsPrkag3
CarcinogenesisBraf , Gsk3b , Kras
CarcinomaHras , Kras , Pik3r1 , Rasa1 , Sgk1
Carcinoma in SituAkt1
Carcinoma, Adenoid CysticFoxo3 , Hras , Map2k2 , Pik3ca , Pygb
Carcinoma, Basal CellPik3ca , Rasa1
Carcinoma, Ductal, BreastCrkl , Socs1 , Socs2 , Socs3
Carcinoma, EndometrioidKras
Carcinoma, HepatocellularAcaca , Akt2 , Braf , Fasn , Fbp1 , Hras , Irs1 , Irs2 , Kras , Mtor , Pck1 , Pik3ca , Pygl , Rps6 , Shc1 , Socs3 , Srebf1 , Tsc1
Carcinoma, Intraductal, NoninfiltratingPrkca , Socs1 , Socs2 , Socs3
Carcinoma, Large CellPrkca
Carcinoma, Non-Small-Cell LungAkt1 , Braf , Cbl , Foxo3 , Hras , Kras , Map2k1 , Nras , Pik3ca , Raf1 , Rheb
Carcinoma, Pancreatic DuctalIns2 , Kras , Tsc2
Carcinoma, Renal CellAkt1 , Bad , Cav1 , Insr , Kras , Map2k1 , Mtor , Pik3ca , Tsc1 , Tsc2
Carcinoma, Small CellMtor
Carcinoma, Squamous CellAkt1 , Cav1 , Hras , Kras , Mapk1 , Mapk3 , Pik3ca , Ptpn11 , Rasa1 , Tsc1 , Tsc2
Carcinoma, Squamous Cell of Head and NeckAkt1 , Pik3ca
Carcinoma, Transitional CellCav1 , Hras , Kras , Nras
Cardiac Output, LowPpp1ca
Cardiofaciocutaneous SyndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Bad , Cav1 , Gsk3b , Mapk1 , Mapk8 , Mtor , Pik3cg , Ppargc1a , Prkaa2 , Prkca , Prkcb , Pygm , Rps6kb1 , Shc1 , Slc2a4
CardiomyopathiesAkt1 , Insr , Kras , Mapk1 , Mapk3 , Prkaa2 , Prkag2
Cardiomyopathy, DilatedFasn , Kras , Ppargc1a , Ppp1ca , Prkca , Prkcb , Ptpn11 , Raf1 , Rps6kb1
CARDIOMYOPATHY, DILATED, 1NNRaf1
Cardiomyopathy, Familial Hypertrophic, 1Prkag2
Cardiomyopathy, Familial Hypertrophic, 6Prkag2
Cardiomyopathy, HypertrophicFasn , Ins2 , Kras , Prkaca , Prkag2 , Ptpn11 , Raf1 , Sos1
Cardiomyopathy, Hypertrophic, FamilialKras , Prkag2 , Raf1 , Sos1
Cardiovascular AbnormalitiesMap2k1
Cardiovascular DiseasesEnpp1 , Gys1 , Ppargc1a
Carney ComplexPrkar1a
Carotid Artery InjuriesCbl , Foxo3 , Ppargc1a
Cecal NeoplasmsKras
Cell Transformation, NeoplasticHras , Irs1 , Kras , Mapk8
Cerebral HemorrhageMtor
Ceroid Lipofuscinosis, Neuronal 1, InfantilePpargc1a , Rps6kb1
Ceroid Lipofuscinosis, Neuronal, 6Gsk3b , Mapk1 , Mapk3
CholangiocarcinomaKras , Prkaca , Prkacb
CholestasisPygm
ChondrosarcomaMtor
ChoriocarcinomaInsr
Choroidal NeovascularizationIkbkb
Chromosome 17q12 Deletion SyndromeAcaca
Chromosome 1q21.1 Deletion Syndrome, 1.35-MbPrkab2
Chronic Allograft DysfunctionMtor
Chronic Intermittent HypoxiaHk1 , Hk2
Cocaine-Related DisordersCalm1 , Mapk1 , Mapk3
Cognition DisordersTsc1
Cole DiseaseEnpp1
ColitisIkbkb , Pik3cg , Ppargc1a
Colonic NeoplasmsAkt1 , Akt2 , Bad , Braf , Crkl , Fbp1 , Ikbkb , Kras , Nras , Pik3ca , Pik3r1 , Prkaa1
Colorectal NeoplasmsAkt1 , Braf , Hk1 , Kras , Nras , Pik3ca , Pik3cg , Prkcb
Congenital HyperinsulinismGck
Congenital HypothyroidismPpargc1a
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Cornelia De Lange Syndrome 5Phka1
Coronary Artery DiseaseAkt1 , Gck , Irs1
Coronary DiseaseIrs1
Coronary RestenosisMapk1
Costello SyndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
COWDEN SYNDROME 5Pik3ca
CraniopharyngiomaBraf
CryptorchidismCbl
Currarino TriadPik3ca
Cushing SyndromePrkar1a
Cystadenocarcinoma, MucinousSgk1
Cystadenocarcinoma, SerousSgk1
Cystitis, InterstitialMtor
Dementia, VascularEif4e , Mtor , Rps6
Depressive DisorderGsk3b
Depressive Disorder, MajorCalm2
Dermal FibrosisCav1
DermatitisIkbkb
Dermatitis, Allergic ContactSocs1 , Socs2
Dermatitis, AtopicMapk8
Dermatitis, Atopic, 4Socs3
Developmental DisabilitiesAkt3 , Cbl
Diabetes ComplicationsEnpp1 , Prkaa1
Diabetes Insipidus, NephrogenicPrkca
Diabetes MellitusGck , Ins1 , Ins2 , Insr , Irs1
Diabetes Mellitus, ExperimentalAkt1 , Bad , Cav1 , Foxo3 , G6pc , Gck , Hk1 , Hras , Ikbkb , Insr , Irs1 , Irs2 , Mapk1 , Mapk3 , Pck1 , Pde3a , Phka1 , Pik3r1 , Pklr , Ppargc1a , Prkca , Prkcb , Prkci , Pygm , Slc2a4 , Socs3 , Srebf1 , Tsc2
Diabetes Mellitus, Insulin-Dependent, 2Ins1 , Ins2
Diabetes Mellitus, Insulin-Resistant, with Acanthosis NigricansInsr
Diabetes Mellitus, LipoatrophicInsr
Diabetes Mellitus, New-Onset after TransplantationMtor
Diabetes Mellitus, Permanent NeonatalGck , Ins1 , Ins2
Diabetes Mellitus, Type 1Cbl , Cblb , Foxo1 , Ins2 , Ppargc1a , Prkcq
Diabetes Mellitus, Type 2Akt1 , Akt2 , Bad , Calm1 , Enpp1 , Foxo1 , G6pc , Gck , Grb14 , Gsk3b , Hk1 , Hk2 , Ikbkb , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Lipe , Pck1 , Pik3r1 , Ppargc1a , Ppp1r3a , Prkaa1 , Prkaa2 , Prkcb , Ptpn1 , Slc2a4 , Socs3 , Sorbs1 , Srebf1
Diabetes, GestationalG6pc , Gck , Ins2 , Insr
Diabetic CardiomyopathiesBad , Ins2
Diabetic CystopathyBad
Diabetic KetoacidosisIns2 , Insr
Diabetic NephropathiesEnpp1 , Ins2 , Irs2 , Mapk1 , Mtor , Ppargc1a , Prkcb , Srebf1 , Trip10
Diabetic NeuropathiesBad , Cav1 , Insr , Sgk1 , Srebf1
Diabetic RetinopathyHras , Ins2 , Ppargc1a
DiGeorge SyndromeCrkl
Disease Models, AnimalAkt1 , Kras , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Prkcg
Disease ProgressionHras , Prkab1 , Ptprf , Rps6
Diseases of the AgedPpargc1a
Donohue SyndromeInsr
Drug-Induced Liver InjuryBad , Fasn
Dysembryoplastic Neuroepithelial TumorBraf
Dyskinesia, Drug-InducedMtor
EdemaIns2
Encephalomyelitis, Autoimmune, ExperimentalCblb , Pik3cg , Prkaa1
EnchondromatosisPtpn11
Endometrial HyperplasiaKras
Endometrial NeoplasmsKras , Pik3ca , Prkca , Socs2 , Socs3
EndometriosisEnpp1 , Kras
EndotoxemiaIrs1 , Pck1 , Pck2 , Prkaa1 , Socs1 , Socs3
Epidermal NevusHras , Kras , Nras , Pik3ca
EpilepsyAkt1 , Tsc1 , Tsc2
Epilepsy, GeneralizedMapk10
Epilepsy, Temporal LobeFoxo3 , Mtor
Epileptic Encephalopathy, Lennox-Gastaut TypeMapk10
Erectile DysfunctionAkt1 , Bad
Exfoliation SyndromeCav1
Exostoses, Multiple HereditaryPtpn11
Facial AsymmetryPik3ca
Fatty LiverAcaca , Acacb , Gck , Ins2 , Mapk8 , Ppargc1a , Prkaa1 , Shc1 , Socs1 , Socs3 , Srebf1
Fetal DiseasesPrkcb
Fetal Growth RetardationElk1 , G6pc , Irs1 , Irs2 , Pck1 , Ppargc1a , Ptpn11 , Srebf1
Fibromatosis, GingivalSos1
Fibromatosis, Gingival, 1Sos1
FibrosisAkt1 , Phkg2 , Pik3cg , Socs3
Focal Cortical Dysplasia of TaylorTsc1
Fructose-1,6-Diphosphatase DeficiencyFbp1
Gallbladder NeoplasmsKras
Gastrointestinal NeoplasmsPik3ca
Gaucher DiseasePklr
Genetic Diseases, InbornCav1 , Mapk1 , Phka2 , Pik3r2
GerminomaBraf
Giant Pigmented Hairy NevusHras , Nras
GlaucomaBad
Glaucoma, Open-AngleCav1
Glaucoma, Primary Open AngleCav1
GlioblastomaAkt1
GliomaAkt2 , Bad , Braf , Cav1 , Pik3ca , Raf1
GliosisMapk1 , Mapk3
GlomerulonephritisMapk1
Glomerulonephritis, CrescenticMtor
Glucose IntoleranceIns2 , Insr , Ppargc1a , Prkaa1 , Prkaa2
Glycogen Storage DiseaseGys2 , Phka1 , Phka2 , Phkg2 , Prkag2 , Pygl
Glycogen Storage Disease 0, LiverGys2
Glycogen Storage Disease 0, MuscleGys1
Glycogen Storage Disease IBG6pc
Glycogen Storage Disease IXa1Phka2
Glycogen Storage Disease IXBPhkb
Glycogen Storage Disease IXCPhkg2
Glycogen Storage Disease of Heart, Lethal CongenitalPrkag2
Glycogen Storage Disease Type IG6pc
Glycogen Storage Disease Type IxPhka1 , Phkb , Phkg2
Glycogen Storage Disease Type VPygm
Glycogen Storage Disease Type VIPygl
Glycogen Storage Disease, Type IXDPhka1
Graft vs Host DiseasePik3cg
Granulosa Cell TumorPrkar2b , Sgk1
Growth DisordersCbl , Pik3ca
Growth Restriction, Severe, with Distinctive FaciesIns1
HamartomaTsc1 , Tsc2
Hamartoma Syndrome, MultipleAkt1 , Pik3ca
Head and Neck NeoplasmsMapk1 , Mapk3
Hearing Loss, Cisplatin-InducedGsk3b
Heart ArrestAkt1 , Ins2
Heart DiseasesLipe , Ppargc1a
Heart FailureAcaca , Cbl , Fasn , Foxo1 , Gsk3b , Ins2 , Mtor , Pck1 , Pdpk1 , Pik3cg , Ppargc1a , Ppp1ca , Prkaca , Prkar2a , Prkar2b , Prkca , Prkcb , Slc2a4
Heart Septal Defects, VentricularBraf
Helicobacter InfectionsSocs3
HemangiomaTsc2
Hemangioma, CapillaryAkt3
HemangiosarcomaHras , Kras
HemimegalencephalyPik3ca
Hemolytic Anemia, Nonspherocytic, due to Hexokinase DeficiencyHk1
HemorrhageCav1
HepatitisIns2
Hepatitis, AcuteTsc2
Hepatitis, ChronicShc1
Hepatorenal Form of Glycogen Storage DiseaseG6pc
Hernias, Diaphragmatic, CongenitalCbl , Insr
Hirschsprung DiseaseTsc2
Hirschsprung Disease 1Tsc2
Histiocytoma, Malignant FibrousPpargc1a
HIV InfectionsEif4ebp1 , Socs1 , Socs3
Hodgkin DiseasePtpn1
Huntington DiseaseElk1 , Ppargc1a , Prkaa1 , Trip10
HyperalgesiaInsr , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Mtor , Prkcb , Prkcg , Raf1
HyperammonemiaPrkcq
HypercholesterolemiaSrebf1
Hyperferritinemia, Hereditary, with Congenital CataractsGys1
HyperglycemiaCbl , Gck , Ins2 , Insr , Irs2 , Pck1 , Pklr , Ppargc1a , Prkcb , Prkcz , Shc1
Hyperinsulinemic Hypoglycemia, Familial, 3Gck
Hyperinsulinemic Hypoglycemia, Familial, 5Insr
HyperinsulinismGck , Ins2 , Insr , Irs1 , Pklr , Prkcq , Ptprf , Rps6kb1
HyperkalemiaIns2
HyperlipidemiasIrs1 , Shc1
HyperplasiaAkt1 , Cav1 , Ikbkb , Pik3ca
HyperproinsulinemiaIns1 , Ins2
HypertensionAkt1 , Akt2 , Bad , Cav1 , Gck , Gsk3b , Ikbkb , Ins2 , Kras , Lipe , Mapk8 , Mtor , Pik3r1 , Prkca , Prkcb , Rps6kb1 , Sgk1
Hypertension, PortalMtor , Pik3r1
Hypertension, PulmonaryCav1 , Hk1 , Mtor , Pde3a , Slc2a4
Hypertensive NephropathyShc1
HyperthyroidismPpargc1a
HypertriglyceridemiaIns2 , Lipe , Mtor , Socs1 , Socs3
HypertrophyMapk1 , Mapk3
Hypertrophy, Left VentricularEnpp1 , Foxo3 , Mtor , Ppargc1a , Prkca , Prkcb , Prkcz , Rasa1 , Rps6kb1 , Shc1
Hypertrophy, Right VentricularAkt1 , Mtor , Ppargc1a , Prkca
HyperuricemiaIns2
Hypoglossal Nerve InjuriesPrkaca , Prkacb
HypoglycemiaAkt2 , Gck , Ins2 , Pik3r1 , Ppp1r3a
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
HypokalemiaIns2
Hypophosphatemic Rickets, Autosomal Recessive, 2Enpp1
HypoproteinemiaRps6kb1
HypotensionIns2
HypothyroidismBad , Cav1 , Phka1
Hypoxia-Ischemia, BrainFoxo3
Idiopathic Interstitial PneumoniasMtor
Immune System DiseasesPrkcb
Immunodeficiency 14Pik3cd
Immunodeficiency 15Ikbkb
Immunodeficiency 36Pik3r1
Infarction, Middle Cerebral ArteryBad , Ikbkb , Mtor
Infertility, FemaleMapk1 , Mapk3 , Tsc2
InflammationAkt1 , Mtor , Pik3cg
Inflammatory Bowel DiseasesIkbkb
Insulin ResistanceAcaca , Acacb , Akt2 , Bad , Cblb , Enpp1 , Foxo1 , Gck , Gys1 , Ikbkb , Ins2 , Insr , Irs1 , Irs2 , Pde3a , Pik3r1 , Pklr , Ppargc1a , Ppp1r3a , Prkaa1 , Prkaa2 , Prkcb , Prkcq , Prkcz , Ptpn1 , Ptprf , Shc1 , Slc2a4 , Socs1 , Socs3 , Sorbs1 , Srebf1 , Tsc1
InsulinomaIns2
Intellectual DisabilityFasn , Kras , Prkcg , Tsc1 , Tsc2
Intermittent ClaudicationBad
Intervertebral Disc DegenerationCrk
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsPrkca
Intimal HyperplasiaFoxo3
IschemiaAkt2 , Mapk9 , Prkca , Raf1
Ischemic Attack, TransientBad , Cav1 , Cbl , Elk1 , Ikbkb , Rps6 , Sgk1
Kearns-Sayre SyndromePpargc1a
KeratoconusFoxo1
Keratosis, SeborrheicPik3ca
Kidney DiseasesMapk1 , Srebf1
Kidney Diseases, CysticIns2
Kidney Failure, ChronicEnpp1 , Fasn , Irs1 , Mtor , Srebf1
Kidney NeoplasmsAkt1 , Braf , Eif4ebp1 , Kras , Mapk1 , Mapk3 , Ppargc1a , Raf1 , Tsc1 , Tsc2
Kidney Reperfusion InjuryIkbkb , Ppargc1a
LeiomyomaCav1 , Tsc2
LEOPARD SyndromeBraf , Ptpn11 , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD syndrome, 2Raf1
LeukemiaBad , Nras , Prkcz , Ptpn11
Leukemia, ExperimentalCbl , Nras
Leukemia, Hairy CellMap2k1
Leukemia, Lymphocytic, Chronic, B-CellCbl
Leukemia, Megakaryoblastic, of Down SyndromeNras
Leukemia, Myeloid, AcuteCbl , Eif4ebp1 , Foxo1 , Kras , Nras , Sgk1 , Tsc2
Leukemia, Myelomonocytic, ChronicNras
Leukemia, Myelomonocytic, JuvenileCbl , Kras , Nras , Ptpn11
Leukemia, Promyelocytic, AcuteAkt1 , Nras , Prkar1a
Leukemia-Lymphoma, Adult T-CellNras , Prkcb
Lewy Body DiseaseElk1 , Ins2 , Insr
Lipid Metabolism, Inborn ErrorsPrkag3
LipidosesSrebf1
LipodystrophyInsr
Lipodystrophy with Congenital Cataracts and NeurodegenerationCav1
Lipodystrophy, Congenital Generalized, Type 3Cav1
Lipodystrophy, Familial PartialAkt2 , Cav1 , Ppp1r3a
LiposarcomaFasn
Liver CirrhosisPhkg2
Liver Cirrhosis, BiliaryPpargc1a , Rps6kb1
Liver Cirrhosis, ExperimentalCav1 , G6pc , Gck , Inpp5d , Ins2 , Mtor , Pck1 , Pck2 , Pklr , Ppp1r3b , Ppp1r3c , Prkcb , Ptpn1 , Rhoq , Socs1 , Socs2 , Srebf1
Liver DiseasesHk3 , Socs1 , Socs3
Liver Diseases, AlcoholicCav1
Liver Diseases, ParasiticKras
Liver FailureRps6
Liver Failure, AcuteIns1 , Ins2 , Mapk8
Liver InjuryGck
Liver NeoplasmsBraf , Hras , Kras , Pik3ca , Raf1
Liver Neoplasms, ExperimentalHras , Kras , Map2k1 , Socs1
Liver Reperfusion InjuryBad , Mapk8
Long QT SyndromeHk3 , Pik3cg
Long QT Syndrome 1Calm3
Low Tension GlaucomaCav1
Lung DiseasesInsr
Lung InjuryMtor
Lung NeoplasmsAkt1 , Braf , Crkl , Dok1 , Hras , Kras , Mapk1 , Mapk3 , Mtor , Pik3ca , Raf1 , Tsc1
Lupus Erythematosus, SystemicPik3cg
Lupus NephritisMtor
LymphangioleiomyomatosisTsc1 , Tsc2
Lymphatic MetastasisCav1 , Socs2 , Socs3 , Tsc2
LymphomaKras , Nras
Lymphoma, B-CellNras , Ptpn1
Lymphoma, Large B-Cell, DiffusePdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3cg , Rps6kb1
Lymphoma, Mantle-CellEif4e , Eif4ebp1 , Gsk3b , Mtor , Pik3cd
Lymphoma, Non-HodgkinBraf
Lymphoma, T-CellAkt1
Lymphoma, T-Cell, CutaneousBraf , Prkcq
LymphopeniaCbl
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
Macular DegenerationBad , Ppargc1a
MalariaPklr
Malformations of Cortical DevelopmentAkt3 , Mtor , Pik3ca , Tsc1
Malformations of Cortical Development, Group IIPhka2
Mammary Neoplasms, AnimalHras , Pik3r1 , Rasa1 , Sgk1
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Cav1 , Hras , Mtor , Pik3r1 , Rasa1 , Sgk1 , Socs1 , Socs3
Mandibular NeoplasmsBraf
Marijuana AbuseAkt1 , Calm1
Maturity-Onset Diabetes of the YoungGck , Ins1 , Ins2
Maturity-Onset Diabetes of the Young, Type 1Ins2
Maturity-Onset Diabetes of the Young, Type 10Ins1 , Ins2
Maturity-Onset Diabetes of the Young, Type 2Gck
Mauriac SyndromePhkg2
Meckel Syndrome Type 1Exoc4
Mediastinal NeoplasmsPtpn1
MedulloblastomaIrs2 , Pik3cg , Tsc2
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
MelanomaBraf , Cav1 , Cbl , Fasn , Map2k1 , Map2k2 , Nras , Pck1 , Pik3ca , Ppargc1a , Prkag2
Melanoma, Cutaneous Malignant, Susceptibility To, 1Braf , Cbl , Nras , Pck1 , Pik3ca , Prkag2
Melanoma, ExperimentalIkbkb
Memory DisordersIns2
MeningiomaAkt1
Mesangial Proliferative GlomerulonephritisRapgef1
MesotheliomaMtor
Mesothelioma, MalignantPtprf , Raf1
Metabolic DiseasesIns2 , Srebf1
Metabolic Syndrome XIns2 , Irs1 , Ppargc1a
MetachondromatosisPtpn11
Microsatellite InstabilityBraf
Mineralocorticoid Excess Syndrome, ApparentPrkar1a
Monoclonal B-Cell LymphocytosisRapgef1
Mood DisordersAkt1
Mouth NeoplasmsHras , Kras , Nras , Pik3ca , Tsc1 , Tsc2
Multiple MyelomaCbl , Hk1 , Kras , Nras
Multiple Organ FailureMapk1
Multiple SclerosisCav1 , Cblb
Muscular AtrophyAkt1 , Gsk3b , Ikbkb , Mtor , Rps6kb1
Muscular DiseasesIns2 , Pygm
Muscular Dystrophy, AnimalMtor , Ppargc1a
Myelodysplastic SyndromesNras
Myeloproliferative DisordersCbl , Kras , Nras
Myocardial InfarctionAkt1 , Gsk3b , Mapk1 , Mtor , Pde3a , Pik3cg , Ppargc1a , Rps6kb1 , Socs1
Myocardial IschemiaCrk , Eif4e , Eif4ebp1 , Hk1 , Hk2 , Ptpra , Pygb , Pygm , Socs3
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Cbl , Gsk3b , Mapk1 , Mapk8 , Mapk9 , Pik3cg , Ppargc1a , Prkcb
Myocarditis, Autoimmune, ExperimentalCav1 , Rps6
Myoclonic Epilepsies, ProgressiveTsc1
Myopathy, Congenital, with Excess of Muscle SpindlesHras
MyxomaPrkar1a
NarcolepsySocs2
Nasopharyngeal carcinomaAkt2 , Kras , Pik3ca
Nematode InfectionsPik3r1
Neoplasm InvasivenessHras , Mapk1 , Mapk3
Neoplasm MetastasisAkt2 , Braf , Cav1 , Kras , Mapk1 , Mapk3 , Mapk9 , Mtor
NeoplasmsFasn , Kras
Neoplasms, ExperimentalHras , Kras , Nras
Neoplastic ProcessesHras
Neoplastic Syndromes, HereditaryPik3ca , Tsc1 , Tsc2
NephritisMtor
Nephrogenic Fibrosing DermopathyCav1
Nephrotic SyndromeNck1 , Nck2 , Ppargc1a
Nerve DegenerationMapk1 , Mapk3 , Tsc2
Neural Tube DefectsIns2
Neuritis, Autoimmune, ExperimentalCav1
NeuroblastomaHras , Kras , Nras , Ptpn11
Neurocognitive DisordersIns2
Neurocutaneous MelanosisNras
Neuroendocrine TumorsBraf
NeuroferritinopathyGys1
NeurofibrosarcomaNras
Neuroma, AcousticCav1
Neuropathy, Hereditary Motor and Sensory, Russe TypeHk1
Neurotoxicity SyndromesMtor
NevusBraf
Nevus, PigmentedNras
Nevus, Sebaceous of JadassohnHras , Kras , Nras
Non-alcoholic Fatty Liver DiseaseIrs1 , Irs2 , Ppargc1a , Srebf1
Nonseminomatous Germ Cell TumorBraf
Noonan like syndromeCbl , Ptpn11 , Sos1
Noonan SyndromeBraf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1
Noonan syndrome 3Kras
Noonan Syndrome 4Sos1
Noonan Syndrome 5Raf1
Noonan Syndrome 6Nras
Noonan Syndrome 7Braf
NOONAN SYNDROME 9Sos2
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaCbl
ObesityAcacb , Akt1 , Akt2 , Bad , Cav1 , Enpp1 , Fasn , Foxo3 , Gck , Hk1 , Hk2 , Ikbkb , Ins2 , Irs1 , Irs2 , Lipe , Mtor , Pck1 , Pik3cg , Pik3r1 , Pklr , Ppargc1a , Prkar2b , Prkcb , Ptpn1 , Ptprf , Rps6kb1 , Socs1 , Socs3 , Sorbs1 , Srebf1 , Tsc1
Obsessive-Compulsive DisorderHras
Ossification of Posterior Longitudinal LigamentEnpp1
Ossification of the Posterior Longitudinal Ligament of the SpineEnpp1
OsteoarthritisBad , Cav1 , Ins2 , Mtor
OsteochondromaPtpn11
OsteoporosisIrs1 , Irs2
Ovarian Epithelial CancerPik3ca
Ovarian NeoplasmsAkt1 , Akt2 , Braf , Cav1 , Crkl , Dok1 , Fasn , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1 , Ppp1cc , Prkca , Prkci , Socs1 , Socs2
Oxygen-Induced RetinopathyMapk8
PainAkt1
Pancreatic CarcinomaKras , Mtor , Tsc1
Pancreatic NeoplasmsAkt2 , Ins2 , Kras , Mtor , Tsc2
PancreatitisIkbkb , Ins2
Pancreatitis, ChronicBad
Pancreatitis, Experimental, Acute Kras
Panic DisorderIns2
PapillomaHras
ParalysisIns2 , Pygm
ParaplegiaAkt1
ParesthesiaIns2
Parkinson DiseaseAkt1 , Fbp1 , Gsk3b , Ins2 , Insr , Ppargc1a
Parkinsonian DisordersBad , Mtor , Ppargc1a
Penile NeoplasmsHras , Kras , Pik3ca
PeritonitisGsk3b
Phencyclidine AbuseCalm1
Phobic DisordersHras
Phosphoenolpyruvate Carboxykinase 2 DeficiencyPck2
Phosphoenolpyruvate Carboxykinase DeficiencyPck1
Pigmented Nodular Adrenocortical Disease, Primary, 1Prkar1a
Pigmented Nodular Adrenocortical Disease, Primary, 4Prkaca
Pituitary NeoplasmsPrkca
Placental InsufficiencyPpargc1a
Pleomorphic Xanthoastrocytoma Braf , Tsc1
PneumoniaIkbkb
Pneumonia, PneumococcalMapk1 , Mapk3
PoisoningGsk3b
Polycystic Kidney DiseasesMtor
Polycystic Kidney, Autosomal DominantMtor , Rps6kb1
Polycystic Kidney, Autosomal RecessiveAkt1 , Mtor , Pik3ca
Polycystic Ovary SyndromeIns2 , Pde3b
PolymicrogyriaAkt3
Polymorphic Catecholergic Ventricular TachycardiaCalm1
PolyuriaPrkca
Port-Wine StainRasa1
Precancerous ConditionsHras , Insr , Irs1 , Mapk8 , Mapk9
Precursor Cell Lymphoblastic Leukemia-LymphomaHk1 , Kras , Nras
Precursor T-Cell Lymphoblastic Leukemia-LymphomaKras , Mtor , Ptpn11
Prediabetic StatePpargc1a
Prostatic HyperplasiaBad
Prostatic Intraepithelial NeoplasiaKras
Prostatic NeoplasmsAkt1 , Bad , Braf , Cav1 , Crkl , Exoc2 , Foxo1 , Foxo3 , Gsk3b , Ins2 , Insr , Irs1 , Kras , Map2k1 , Mapk10 , Mapk3 , Mtor , Nras , Pde3a , Pik3ca , Pik3cd , Pik3cg , Pik3r1 , Ppp1r3c , Prkacb , Prkca , Prkcq , Prkcz , Socs1 , Sorbs1
ProteinuriaNck1 , Nck2
Proteus SyndromeAkt1
PsoriasisCav1 , Ikbkb
Psychoses, Substance-InducedAkt1
Pulmonary Disease, Chronic ObstructiveFoxo3 , Mapk8 , Ppargc1a
Pulmonary EmphysemaPpargc1a
Pulmonary FibrosisBad , Cav1
Pulmonary Hypertension, Primary, 3Cav1
Pulmonary Valve StenosisHras
Pyruvate Kinase Deficiency of Red CellsPklr
Q FeverFlot1
Radiation Injuries, ExperimentalMapk1 , Mapk3
RASopathiesBraf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1
Rectal NeoplasmsNras , Pik3ca
RecurrenceHras , Kras
Renal FibrosisKras , Mapk1 , Ppargc1a
Renal InsufficiencyIns2 , Ppargc1a , Tsc1
Renal Insufficiency, ChronicInsr , Ppargc1a
Reperfusion InjuryAkt1 , Bad , Cav1 , Inpp5d , Mapk8 , Mapk9 , Pik3r1 , Pklr , Prkca , Socs1 , Socs3 , Socs4
Retina Reperfusion InjuryBad
Retinal NeovascularizationMtor
Retinitis PigmentosaAcacb , Prkcg
Rett SyndromePtpn1
RhabdomyolysisIns2
Rhabdomyosarcoma, AlveolarFoxo1
Romano-Ward SyndromeCalm3
Salivary Gland NeoplasmsPygb
SarcomaPik3ca
Sarcoma, ExperimentalKras , Nras
Sarcoma, MyeloidKras
SarcopeniaCav1 , Ppargc1a
SchizophreniaAkt1 , Crkl , Elk1 , Gsk3b , Mapk3 , Mtor , Pik3cb , Ppargc1a
Sciatic NeuropathyCav1 , Mtor , Ppargc1a
Scleroderma, LimitedCav1
Scleroderma, SystemicCav1
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
Segawa Syndrome, Autosomal RecessiveIns1 , Ins2
SeizuresBad , Ins2 , Tsc1 , Tsc2
SeminomaHras , Insr , Kras
Senior Loken SyndromeAkt3
SepsisBad , Eif4e , Gsk3b , Irs1 , Mapk1 , Mapk3 , Mtor , Pik3cg , Ppargc1a , Prkcq , Socs1 , Socs2 , Socs3
Septic PeritonitisPik3r1
Sezary SyndromeBraf , Mapk1
Shock, HemorrhagicBad , Mapk1 , Mtor
Short Bowel SyndromeInsr
SHORT SyndromePik3r1
SilicosisPrkcb
Skin NeoplasmsAkt1 , Crkl , Hras
Sleep Initiation and Maintenance DisordersPpargc1a
Small-For-Size SyndromeBad
Smith-Kingsmore SyndromeMtor
Smith-Magenis SyndromeAcaca , Exoc7 , Fasn , Flot2 , G6pc , Grb2 , Prkar1a , Prkca , Rps6kb1 , Rptor , Socs3 , Socs7 , Srebf1
Spasms, InfantileTsc1 , Tsc2
Spinal Cord InjuriesAkt1 , Cav1 , Foxo3 , Mtor , Ppargc1a , Socs2
Spinal Cord Reperfusion InjuryBad
Spinocerebellar Ataxia 14Prkcg
Spinocerebellar Ataxia, X-Linked 1Phka1
Spinocerebellar AtaxiasPrkcg
Splenic NeoplasmsHras
Spondylocostal Dysostosis 5Mapk3
Squamous Cell Carcinoma of the LungKras
Status EpilepticusFoxo3 , Gsk3b , Mtor , Prkcb , Socs3
Stevens-Johnson SyndromeCav1
Stomach NeoplasmsCav1 , Fbp1 , Hras , Irs2 , Kras , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Prkaa1 , Prkab1 , Prkcb , Ptprf , Rps6
Stomach UlcerBad
StrokeAkt1 , Mapk8 , Pik3cg , Prkaa2 , Prkag2
Sturge-Weber SyndromeRasa1
Substance Withdrawal SyndromeMapk1 , Mapk3
Substance-Related DisordersInsr , Mknk1
TachycardiaIns2
Tachycardia, VentricularRaf1
Takotsubo CardiomyopathyPpargc1a
Telomeric 22q13 Monosomy SyndromeIns2
Temporomandibular Joint DisordersMtor
Testicular Germ Cell TumorHras
Tetralogy of FallotPtpn11
ThrombosisPde3a , Pik3cb
Thyroid Cancer, FollicularBraf , Hras , Nras
Thyroid Cancer, MedullaryKras
Thyroid cancer, papillaryBraf , Prkar1a
Thyroid NeoplasmsBraf , Hras , Kras
Tobacco Use DisorderRptor
Tongue NeoplasmsHras
Transplant RejectionIkbkb
Trichilemmoma Hras
Trigeminal NeuralgiaMapk1 , Mapk3 , Mapk8 , Mapk9 , Prkcg
Tuberous SclerosisEif4ebp1 , Tsc1 , Tsc2
Tuberous Sclerosis 1Tsc1 , Tsc2
Tuberous Sclerosis 2Tsc2
Tumor Predisposition SyndromeTsc1 , Tsc2
UremiaSgk1
Ureteral ObstructionAkt1 , Mtor
Urethral ObstructionMapk1
Urinary Bladder DiseasesIns2
Urinary Bladder NeoplasmsAkt1 , Cav1 , Hk1 , Hras , Kras , Mtor , Prkca , Socs1 , Tsc1
Urinary IncontinenceMapk1
Uterine Cervical NeoplasmsHras , Kras , Mtor , Nras
Uterine NeoplasmsKras
VasculitisCbl
Ventilator-Induced Lung InjuryAkt1 , Pik3cg
Ventricular Dysfunction, LeftIns2
Ventricular FibrillationIns2
Ventricular Outflow ObstructionIns2
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1Calm1
Ventricular Tachycardia, Catecholaminergic Polymorphic, 4Calm1
Weight GainCalm1 , Cav1 , Grb14 , Pik3ca
Weight LossIns2
Wet Macular DegenerationMapk8
Wolff-Parkinson-White SyndromePrkag2
Pathway Annotations Associated with Genes in the insulin signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Eif4ebp1 , Grb2 , Hras , Ikbkb , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rps6kb1 , Rps6kb2 , Sos1 , Sos2
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayCalm1 , Calm2 , Calm3 , Ppp1ca , Ppp1cb , Ppp1r3d , Prkaa1 , Prkaa2 , Prkab1 , Prkab2 , Prkag1 , Prkag2 , Prkag3
adenosine signaling pathwayAkt1 , Bad , Braf , Elk1 , Hras , Ikbkb , Map2k2 , Mapk1 , Mapk8 , Pard6a , Pdpk1 , Pik3ca , Prkacb , Prkcz
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
aldosterone signaling pathwayIns1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Kras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkca , Prkcb , Prkcg , Sgk1
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered galactose metabolic pathwayG6pc , Hk2
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered insulin signaling pathwayIns2 , Insr
altered leptin system pathwayInsr
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
Alzheimer disease pathwayBad , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Gsk3b , Mapk1 , Mapk3
amino sugar metabolic pathwayGck , Hk1 , Hk2 , Hk3
amiodarone pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
amlodipine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
amyotrophic lateral sclerosis disease pathwayBad
angiotensin II signaling pathwayPdpk1 , Prkcz
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Ikbkb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkaca , Prkacb , Prkar1a , Prkar2a , Prkar2b , Prkx
atenolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
autophagy pathwayIns1 , Ins2 , Prkaa1 , Prkaa2
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Gsk3b , Hras , Ikbkb , Inpp5d , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcb , Raf1 , Sos1 , Sos2
basal cell carcinoma pathwayGsk3b
betaxolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
bile acid transport pathwayPrkaca , Prkacb , Prkx
bisoprolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
bladder cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
Bone morphogenetic proteins signaling pathwayGsk3b , Mapk1 , Ppp1ca
brain-derived neurotrophic factor signaling pathwayGrb2 , Shc1
bupranolol drug pathwayCalm1 , Prkaca , Prkar1a
bupranolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
butirosin and neomycin biosynthetic pathwayGck , Hk1 , Hk2 , Hk3
c-Jun N-terminal kinases MAPK signaling pathwayMapk10 , Mapk8 , Mapk9 , Rapgef1
calcium/calcium-mediated signaling pathwayCalm1 , Calm2 , Calm3 , Calml3 , Calml5 , Phka1 , Phka2 , Phkb , Phkg1 , Phkg2 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx
calcium/calmodulin dependent kinase 2 signaling pathwayCalm1 , Calm2 , Calm3 , Ppp1cc
carvedilol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
cell cycle pathway, mitoticGsk3b
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ikbkb , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcz , Raf1
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Foxo3 , Grb2 , Gsk3b , Hras , Ikbkb , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkaca , Prkacb , Prkcb , Prkcz , Prkx , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Cblb , Cblc , Crk , Crkl , Grb2 , Hras , Ikbkb , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
citric acid cycle pathwayPck1 , Pck2
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Gsk3b , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
corticosteroid signaling pathwaySgk1
CRM1 export pathwayEif4e
cyclooxygenase mediated pathway of arachidonic acid metabolismMknk1
dilated cardiomyopathy pathwayPrkaca , Prkacb , Prkx
diltiazem pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
disopyramide pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
dobutamine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
dopamine signaling pathwayPpp1ca , Ppp1cb , Ppp1cc , Prkaca , Prkacb
dopamine signaling pathway via D1 family of receptorsPrkacb
E-cadherin signaling pathwayAkt1 , Akt2 , Crk , Exoc3 , Exoc4 , Nck1 , Pik3ca , Pik3r1
eicosanoid signaling pathwayAkt1 , Pik3cg , Pik3r5 , Pik3r6 , Prkaca , Prkca , Prkcg , Prkcq , Prkcz
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPck1 , Pck2 , Pdpk1 , Sorbs1
endocytosis pathwayCav1 , Cbl , Cblb , Cblc , Hras , Pard6a , Prkci , Prkcz
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Elk1 , Foxo3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Endoplasmic Reticulum-associated degradation pathwayMapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Crk , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapk8 , Prkca , Prkcg , Prkcq , Raf1
Entamoeba histolyca infection pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx
ephrin - ephrin receptor bidirectional signaling axisCbl , Crk , Crkl , Grb2 , Hras , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Nck1 , Nck2 , Nras , Pik3ca , Pik3cg , Pik3r1 , Pik3r5 , Pik3r6 , Rasa1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Cblb , Cblc , Crk , Crkl , Eif4ebp1 , Elk1 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Nck1 , Nck2 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Prkcz , Ptpn1 , Ptpn11 , Raf1 , Rasa1 , Rps6kb1 , Rps6kb2 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
erythropoietin signaling pathwayCbl , Crkl , Grb2 , Hras , Inpp5d , Irs2 , Mapk8 , Pik3r1 , Ptpn11 , Shc1 , Socs3 , Sos1
esmolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
facilitative sugar transporter mediated glucose transport pathwaySlc2a4
fanconi syndrome pathwayG6pc , Hk2 , Pklr
FasL mediated signaling pathwayAkt1 , Ikbkb , Mapk10 , Mapk8 , Mapk9 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
fatty acid biosynthetic pathwayAcaca , Acacb , Fasn
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Inpp5d , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcg , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Crk , Crkl , Inpp5d , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Raf1 , Rps6kb1 , Rps6kb2
fibroblast growth factor signaling pathwayAkt1 , Cbl , Grb2 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1 , Ptpn11 , Shc1 , Sos1
flecainde pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
follicle-stimulating hormone signaling pathwayPpp1ca , Prkacb
forkhead class A signaling pathwayAkt1 , G6pc , Gck , Ins2 , Pck1 , Pklr
fosphenytoin pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
french type sialuria disease pathwayHk1
fructose and mannose metabolic pathwayFbp1 , Fbp2 , Hk1 , Hk2 , Hk3
fructose intolerance pathwayFbp1 , Hk1
fructose-1,6-diphosphatase deficiency pathwayFbp1 , G6pc , Hk2 , Pck1
fructosuria disease pathwayFbp1 , Hk1
galactose metabolic pathwayG6pc , Gck , Hk1 , Hk2 , Hk3
GALE deficiency pathwayGck
GALK deficiency pathwayGck
GALT deficiency pathwayG6pc , Gck , Hk1
gliclazide pharmacodynamics pathwayIns2
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
gluconeogenesis pathwayFbp1 , Fbp2 , G6pc , Gck , Hk1 , Hk2 , Hk3 , Pck1 , Pck2 , Pklr
Glut1 deficiency syndrome pathwayG6pc
glutamate signaling pathwayMapk1 , Mapk3 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx
glyburide pharmacodynamics pathwayIns2
glycogen biosynthetic pathwayGck , Gsk3b , Gys1 , Gys2 , Ppp1ca , Ppp1cb , Ppp1cc , Ppp1r3a , Ppp1r3b , Ppp1r3c , Ppp1r3d
glycogen degradation pathwayCalm1 , Calm2 , Calm3 , G6pc , Phka1 , Phka2 , Phkb , Phkg1 , Phkg2 , Ppp1ca , Ppp1cb , Ppp1cc , Ppp1r3a , Ppp1r3b , Ppp1r3c , Ppp1r3d , Pygb , Pygl , Pygm
glycogen metabolic pathwayG6pc , Gck , Gys2 , Pygl
glycogen storage disease pathway, type IAFbp1 , G6pc , Hk2 , Pck1
glycogen storage disease pathway, type IBFbp1 , G6pc , Hk2 , Pck1
glycogen storage disease pathway, type IIIGck , Gys2 , Hk2 , Pygl
glycogen storage disease pathway, type IV.Gck , Gys2 , Hk2 , Pygl
glycogen storage disease pathway, type VIGck , Gys2 , Hk2 , Pygl
glycogen storage disease pathway, type VIIG6pc , Hk2 , Pklr
glycolysis pathwayFbp1 , Fbp2 , G6pc , Gck , Hk1 , Hk2 , Hk3 , Pck1 , Pck2 , Pklr
glycolysis/gluconeogenesis pathwayFbp1 , Fbp2 , G6pc , Gck , Hk1 , Hk2 , Hk3 , Pck1 , Pck2 , Pklr
glypican signaling pathwayMapk8 , Mapk9
gonadotropin-releasing hormone signaling pathwayCalm1 , Calm2 , Calm3 , Calml3 , Calml5 , Elk1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Prkaca , Prkacb , Prkca , Prkcb , Prkx , Raf1 , Sos1 , Sos2
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Ikbkb , Inpp5d , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Prkaca , Prkacb , Ptpn11 , Raf1 , Shc1 , Sos1
Hedgehog signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Prkaca , Prkacb , Prkx
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Grb2 , Gsk3b , Hras , Ikbkb , Kras , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Socs3 , Sos1 , Sos2
histamine signaling pathway, immunologicalPpp1ca , Prkacb
Huntington disease pathwayPpargc1a
hypertrophic cardiomyopathy pathwayPrkaa1 , Prkaa2 , Prkab1 , Prkab2 , Prkag1 , Prkag2 , Prkag3
hypoxia inducible factor pathwayAkt1 , Elk1 , Gck , Hk1 , Hk2
ibutilide pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
inflammatory response pathwayMapk8
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Gsk3b , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Raf1 , Socs3
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Calm1 , Calm2 , Calm3 , Cbl , Crk , Gsk3b , Gys1 , Ins2 , Insr , Ppp1cc , Ppp1r3a , Prkci , Prkcz , Rapgef1 , Rhoq , Slc2a4 , Sorbs1 , Trip10
insulin secretion pathwayGck
insulin signaling pathwayAcaca , Acacb , Akt1 , Akt2 , Akt3 , Bad , Braf , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Cav1 , Cbl , Cblb , Cblc , Crk , Crkl , Dok1 , Eif4e , Eif4e2 , Eif4ebp1 , Elk1 , Enpp1 , Exoc2 , Exoc3 , Exoc4 , Exoc5 , Exoc6 , Exoc7 , F2rl2 , Fasn , Fbp1 , Fbp2 , Flot1 , Flot2 , Foxo1 , Foxo3 , G6pc , Gck , Grb10 , Grb14 , Grb2 , Gsk3b , Gys1 , Gys2 , Hk1 , Hk2 , Hk3 , Hras , Ikbkb , Inpp5d , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Kras , Lipe , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mknk1 , Mknk2 , Mtor , Nck1 , Nck2 , Nras , Pard6a , Pck1 , Pck2 , Pde3a , Pde3b , Pdpk1 , Phka1 , Phka2 , Phkb , Phkg1 , Phkg2 , Pik3ca , Pik3cb , Pik3cd , Pik3cg , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pik3r6 , Pklr , Ppargc1a , Ppp1ca , Ppp1cb , Ppp1cc , Ppp1r3a , Ppp1r3b , Ppp1r3c , Ppp1r3d , Prkaa1 , Prkaa2 , Prkab1 , Prkab2 , Prkaca , Prkacb , Prkag1 , Prkag2 , Prkag3 , Prkar1a , Prkar2a , Prkar2b , Prkca , Prkcb , Prkcg , Prkci , Prkcq , Prkcz , Prkx , Ptpn1 , Ptpn11 , Ptpra , Ptprf , Pygb , Pygl , Pygm , Raf1 , Rapgef1 , Rasa1 , Rheb , Rhoq , Rps6 , Rps6kb1 , Rps6kb2 , Rptor , Sgk1 , Sh2b2 , Shc1 , Shc2 , Shc3 , Shc4 , Slc2a4 , Socs1 , Socs2 , Socs3 , Socs4 , Socs6 , Socs7 , Sorbs1 , Sos1 , Sos2 , Srebf1 , Trip10 , Tsc1 , Tsc2
insulin-like growth factor signaling pathwayAkt1 , Bad , Crk , Crkl , Grb10 , Grb2 , Hras , Irs1 , Irs2 , Irs4 , Nck2 , Pdpk1 , Pik3ca , Pik3r1 , Prkcz , Ptpn1 , Ptpn11 , Raf1 , Rps6kb1 , Shc1 , Sos1
integrin mediated signaling pathwayNck2
interleukin-1 signaling pathwayIkbkb , Mapk8 , Pik3ca , Pik3r1 , Prkci , Prkcz
interleukin-12 signaling pathwayMtor , Socs1
interleukin-2 signaling pathwayGrb2 , Hras , Irs1 , Irs2 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Nras , Pik3ca , Pik3r1 , Prkcb , Ptpn11 , Raf1 , Rasa1 , Shc1 , Socs1 , Socs2 , Socs3 , Sos1
interleukin-23 signaling pathwayPik3ca , Pik3r1 , Socs3
interleukin-3 signaling pathwayGrb2 , Inpp5d , Pik3ca , Pik3r1 , Prkaca , Prkacb , Ptpn11 , Shc1
interleukin-4 signaling pathwayAkt1 , Cbl , Grb2 , Inpp5d , Irs1 , Irs2 , Mtor , Pik3ca , Pik3r1 , Rps6kb1 , Shc1 , Socs1 , Socs3
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1 , Ptpn11
interleukin-6 signaling pathwayAkt1 , Foxo1 , Grb2 , Pik3ca , Pik3r1 , Ptpn11 , Socs3 , Sos1 , Sos2
intrinsic apoptotic pathwayBad
isoprenaline pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
isradipine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn1 , Ptpn11 , Socs1 , Socs2 , Socs3 , Socs4 , Socs6 , Socs7 , Sos1 , Sos2
lactose biosynthetic pathwayG6pc
Leigh syndrome pathwayAcaca , Pck1 , Pklr
Leishmania infection pathwayElk1 , Mapk1 , Mapk3 , Prkcb
leptin system pathwayIrs1 , Irs2 , Ptpn1 , Ptpn11 , Socs3
levobunolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
lidocaine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
long term depressionBraf , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Raf1
long term potentiationBraf , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Ppp1ca , Ppp1cb , Ppp1cc , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx , Raf1
luteinizing hormone signaling pathwayPpp1ca , Prkacb
malonic aciduria disease pathwayAcaca
malonic aciduria pathwayAcaca
maturity onset diabetes of the young pathwayGck , Ins1 , Ins2 , Pklr
measles infection pathwayAkt1 , Akt2 , Akt3 , Cblb , Dok1 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcq
melanocortin system pathwayPrkacb
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
methylmalonic aciduria, cobalamin-related, disease pathwayAcaca
metoprolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
mexiletine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Elk1 , Grb2 , Hras , Ikbkb , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mknk1 , Mknk2 , Nras , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx , Raf1 , Rasa1 , Shc1 , Sos1 , Sos2 , Tsc2
monoterpenoid biosynthetic pathwayEnpp1
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Eif4e , Eif4e2 , Eif4ebp1 , Hras , Ikbkb , Ins1 , Ins2 , Irs1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkaa1 , Prkaa2 , Prkca , Raf1 , Rheb , Rps6 , Rps6kb1 , Rps6kb2 , Rptor , Sgk1 , Srebf1 , Tsc1 , Tsc2
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Raf1
myocarditis pathwayCav1
N-cadherin signaling pathwayCalm1 , Calm2 , Calm3 , Mapk8 , Pik3ca , Pik3r1 , Ptpn1 , Ptpn11
nadolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
nebivolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Crk , Crkl , Foxo3 , Grb2 , Gsk3b , Hras , Ikbkb , Irs1 , Irs2 , Irs3 , Irs4 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Rapgef1 , Sh2b2 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
niacin metabolic pathwayEnpp1
nifedipine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
nimodipine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
nisoldipine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
nitrendipine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
NOD-like receptor signaling pathwayIkbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Raf1 , Sos1 , Sos2
Notch signaling pathwayCbl
nuclear factor kappa B signaling pathwayIkbkb , Pik3ca , Pik3r1 , Prkca
nuclear factor, erythroid 2 like 2 signaling pathwayGsk3b , Ikbkb
nucleotide sugar metabolic pathwayGck , Hk1 , Hk2 , Hk3
p38 MAPK signaling pathwayCalm1 , Calm2 , Calm3 , Mknk1 , Mknk2
p53 signaling pathwayAkt1 , Gsk3b , Mapk8 , Mapk9 , Tsc2
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ikbkb , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
pantothenic acid metabolic pathwayEnpp1
penbutolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
pentose phosphate pathwayFbp1 , Fbp2
phenytoin pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Hras , Inpp5d , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3cg , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pik3r6 , Sgk1
phosphatidylinositol 3-kinase signaling pathwayCalm1 , Calm2 , Calm3 , Calml3 , Calml5 , Inpp5d , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Foxo1 , Foxo3 , Gsk3b , Inpp5d , Mtor , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca , Raf1 , Slc2a4
phosphoenolpyruvate carboxykinase deficiency pathwayFbp1 , G6pc , Hk2 , Pck1
phosphoinositide metabolic pathwayInpp5d , Pik3ca , Pik3cd , Pik3r1
pindolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
platelet-derived growth factor signaling pathwayBraf , Cav1 , Cbl , Crk , Crkl , Dok1 , Elk1 , Grb10 , Grb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nck1 , Nck2 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3cg , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pik3r6 , Prkca , Ptpn1 , Ptpn11 , Raf1 , Rasa1 , Shc1 , Sos1
potassium channel inhibitors pharmacodynamics pathwayIns2
primary hyperoxaluria type 2 disease pathwayAcaca , Pck1 , Pklr
prion diseases pathwayElk1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Prkaca , Prkacb , Prkx
procainamide pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
propanoate metabolic pathwayAcaca , Acacb
propranolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
prostaglandin D2 signaling pathwayPrkacb
prostaglandin I2 signaling pathwayPrkacb
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo1 , Grb2 , Gsk3b , Hras , Ikbkb , Ins1 , Ins2 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
protease mediated signaling via protease-activated receptor 3F2rl2
protein kinase A (PKA) signaling pathwayPde3a , Pde3b , Prkaca , Prkacb , Prkar1a , Prkar2a , Prkar2b
protein kinase C (PKC) signaling pathwayPard6a , Pdpk1 , Prkca , Prkcb , Prkcg , Prkci , Prkcq , Prkcz , Rasa1
purine metabolic pathwayEnpp1 , Pde3a , Pde3b , Pklr
pyruvate dehydrogenase complex deficiency pathwayAcaca , Pck1 , Pklr
pyruvate dehydrogenase E1 deficiency pathwayAcaca , Pck1 , Pklr
pyruvate kinase deficiency pathwayAcaca , Pck1 , Pklr
pyruvate metabolic pathwayAcaca , Acacb , Pck1 , Pck2 , Pklr
quinidine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
Ras family mediated signaling pathwaySos1
Reelin signaling pathwayAkt1 , Cbl , Crkl , Gsk3b , Mapk8 , Nck2 , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Rapgef1 , Sos1 , Sos2
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayIkbkb , Mapk10 , Mapk8 , Mapk9
reverse cholesterol transport pathwayCav1
Rheb mediated signaling pathwayRheb
Rho/Rac/Cdc42 mediated signaling pathwayCbl , Crk , Mapk8 , Rapgef1 , Rhoq , Sorbs1
riboflavin metabolic pathwayEnpp1
ribose 5-phosphate isomerase deficiency pathwayFbp1
ribosome biogenesis pathwayPrkcb
RNA transport pathwayEif4e , Eif4e2 , Eif4ebp1
scatter factor/hepatocyte growth factor signaling pathwayCbl , Crkl , Grb2 , Pik3r1 , Ptpn11 , Shc1
serotonin signaling pathway via receptors engaging G alphas protein familyPpp1ca , Prkacb
sialic acid storage disease pathwayHk1
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
somatostatin signaling pathwayPtpn11
sotalol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Elk1 , Irs1 , Mapk1 , Mapk3 , Mapk8
starch and sucrose metabolic pathwayEnpp1 , G6pc , Gck , Gys1 , Gys2 , Hk1 , Hk2 , Hk3 , Pygb , Pygl , Pygm
sterol regulatory element-binding protein signaling pathwaySrebf1
Sucrase-isomaltase deficiency pathwayGck , Gys2 , Hk2 , Pygl
syndecan signaling pathwayHras , Mapk1 , Mapk3 , Mapk8 , Prkaca , Prkca , Rasa1
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Gsk3b , Hras , Ikbkb , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapk9 , Nck1 , Nck2 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Tay-Sachs disease pathwayHk1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mknk1 , Mknk2 , Nras , Raf1 , Shc1 , Tsc2
thyroid cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras
timolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs1
Trail mediated signaling pathwayIkbkb , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transaldolase deficiency pathwayFbp1
transforming growth factor-beta signaling pathwayTsc2
transforming growth factor-beta Smad dependent signaling pathwayCav1 , Foxo1 , Foxo3 , Grb2 , Pard6a , Pdpk1 , Ppp1ca , Rps6kb1 , Shc1 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Rps6kb1 , Rps6kb2
translation initiation pathwayEif4e
trehalose degradation pathwayGck
triosephosphate isomerase deficiency pathwayFbp1 , G6pc , Hk2 , Pck1
Trypanosoma brucei infection pathwayPrkca , Prkcb , Prkcg
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
tumor necrosis factor mediated signaling pathwayCav1 , Ikbkb , Prkci , Prkcz
type 1 diabetes mellitus pathwayIns1 , Ins2
type 2 diabetes mellitus pathwayAkt2 , Gck , Hk1 , Hk2 , Hk3 , Ikbkb , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pklr , Prkcz , Slc2a4 , Socs1 , Socs2 , Socs3 , Socs4
type II interferon signaling pathwayAkt1 , Calm1 , Calm2 , Calm3 , Cbl , Crkl , Map2k1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1 , Ptpn11 , Socs1
ubiquitin/proteasome degradation pathwayCbl , Cblb , Cblc , Socs1 , Socs3
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Calm1 , Calm2 , Calm3 , Cav1 , Cbl , Grb10 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nck1 , Nck2 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkaa1 , Prkaa2 , Prkab1 , Prkaca , Prkag1 , Prkca , Prkcb , Prkcg , Prkcz , Ptpn11 , Raf1 , Shc2
vasopressin signaling pathway via receptor type 2Prkaca , Prkacb , Prkx
verapamil pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
visual phototransduction pathwayCalm1 , Calm2 , Calm3 , Calml3 , Calml5
Wnt signaling pathwayGsk3b , Mapk10 , Mapk8 , Mapk9 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx
Wnt signaling, canonical pathwayCav1 , Gsk3b , Tsc2
Wnt signaling, non-canonical pathwayMapk10 , Mapk8 , Mapk9 , Prkcz
Phenotype Annotations Associated with Genes in the insulin signaling pathway

References Associated with the insulin signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: