EXTRINSIC APOPTOTIC PATHWAY (PW:0000106)

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Description

Apoptosis, or programmed cell death, removes excess or damaged cells to maintain tissue homeostasis. The two major apoptotic pathways – the extrinsic, triggered by ligands activating the death receptors and the intrinsic (mitochondrial), triggered by intracellular stresses – converge on the activation of executioner caspases. The ligands and their cognate death receptors belong to the tumor necrosis factor (TNF) superfamilies of ligands and receptors. FasL, Trail and Tnf itself are t

Pathway Diagram:

Ariadne Genomics Inc. pro-inflammatory pro-growth cell death adapter1 adapter2 tumor necrosis factor mediated signaling pathway adapter2 --+> tumor necrosis factor mediated signaling pathway DISC Trail mediated signaling pathway FasL mediated signaling pathway death receptors --+> FasL mediated signaling pathway adapter1 ---- adapter2 adapter2 ---- death receptors death receptors --+> tumor necrosis factor mediated signaling pathway death receptors --+> Trail mediated signaling pathway adapter1 ---- death receptors death receptor ligands death receptor agonists death receptor agonists ---- death receptors death receptor ligands ---- death receptors death receptors
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Genes in Pathway:

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extrinsic apoptotic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:2314187
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:2314187
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:2314187
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:1626509
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:1582433
FasL mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:2314002
RGD:4143196
RGD:6484113
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6484113
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6484113
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:6484113
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:4143196
RGD:6484113
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:4143196
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:2314002
RGD:4143196
RGD:6484113
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:4143196
RGD:6484113
RGD:8662854
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6484113
G Cltc clathrin heavy chain JBrowse link 10 74,014,560 74,070,578 RGD:6484113
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:6484113
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:4143196
RGD:6484113
G Faim2 Fas apoptotic inhibitory molecule 2 JBrowse link 7 141,158,769 141,185,781 RGD:6484113
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:2314002
RGD:4143196
RGD:6484113
RGD:8662854
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:2314002
RGD:4143196
RGD:6484113
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6484113
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6484113
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6484113
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6484113
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:6484113
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6484113
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6484113
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6484113
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6484113
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6484113
G Rfc1 replication factor C subunit 1 JBrowse link 14 44,627,528 44,702,205 RGD:6484113
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:6484113
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:6484113
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6484113
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:6484113
Trail mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:4143170
RGD:4143171
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:4143170
RGD:4143171
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:4143171
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:4143170
RGD:4143171
RGD:6484113
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:4143170
RGD:4143171
RGD:6484113
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6484113
G Dap3 death associated protein 3 JBrowse link 2 188,225,607 188,255,324 RGD:6484113
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:4143170
RGD:4143171
RGD:6484113
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6484113
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6484113
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6484113
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6484113
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6484113
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6484113
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6484113
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6484113
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:6484113
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:6484113
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b JBrowse link 15 51,433,853 51,464,215 RGD:4142856
RGD:4143170
RGD:4143171
RGD:6484113
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:2312745
RGD:4143170
RGD:4143171
RGD:6484113
G Tradd TNFRSF1A-associated via death domain JBrowse link 19 37,214,461 37,221,099 RGD:6484113
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:6484113
tumor necrosis factor mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:2292150
RGD:6484113
G Bag4 BCL2-associated athanogene 4 JBrowse link 16 71,057,709 71,075,874 RGD:2292150
RGD:6484113
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6484113
RGD:7800730
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6484113
RGD:7800730
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6484113
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6484113
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:2292150
RGD:6484113
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:6484113
RGD:7800734
RGD:7800735
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:2292150
RGD:6484113
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:2292150
RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:2292150
RGD:6484113
G Itch itchy E3 ubiquitin protein ligase JBrowse link 3 150,660,665 150,752,016 RGD:7800734
RGD:7800735
G Madd MAP-kinase activating death domain JBrowse link 3 79,960,301 80,003,023 RGD:6484113
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:6484113
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6484113
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6484113
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:6484113
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:5490225
RGD:6484113
G Map4k2 mitogen activated protein kinase kinase kinase kinase 2 JBrowse link 1 221,710,622 221,726,274 RGD:6484113
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 JBrowse link 6 3,276,732 3,444,519 RGD:6484113
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 JBrowse link 9 46,657,444 46,782,545 RGD:6484113
G Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 JBrowse link 6 92,136,242 92,229,578 RGD:6484113
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6484113
G Nrk Nik related kinase JBrowse link X
X
109,940,439
110,065,199
110,036,361
110,089,124
RGD:6484113
G Nsmaf neutral sphingomyelinase activation associated factor JBrowse link 5 19,499,111 19,560,308 RGD:6484113
G Prkci protein kinase C, iota JBrowse link 2 115,941,998 116,002,550 RGD:6484113
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6484113
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:6484113
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 3 147,793,014 147,809,941 RGD:7800730
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6484113
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase JBrowse link 10 70,157,621 70,220,618 RGD:6484113
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:2292150
RGD:6484113
RGD:7800730
G Rnf11 ring finger protein 11 JBrowse link 5 129,296,271 129,298,513 RGD:7800734
RGD:7800735
G Rnf31 ring finger protein 31 JBrowse link 15 34,270,037 34,282,385 RGD:7800730
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,455 RGD:7800730
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:6484113
G Smpd2 sphingomyelin phosphodiesterase 2 JBrowse link 20 46,212,070 46,215,183 RGD:6484113
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6484113
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6484113
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:5490225
RGD:6484113
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:5490225
RGD:6484113
G Tab3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 JBrowse link X 54,035,958 54,090,282 RGD:5490225
G Tax1bp1 Tax1 binding protein 1 JBrowse link 4 82,776,720 82,832,586 RGD:7800734
RGD:7800735
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1580210
RGD:2292150
RGD:6484113
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:7800734
RGD:7800735
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:2292150
RGD:5130945
RGD:6484113
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:2292150
RGD:6484113
G Tnik TRAF2 and NCK interacting kinase JBrowse link 2 113,984,599 114,391,805 RGD:6484113
G Tradd TNFRSF1A-associated via death domain JBrowse link 19 37,214,461 37,221,099 RGD:2292150
RGD:6484113
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:2292150
RGD:5130945
RGD:6484113
RGD:7800730
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Proteinadapter1Fadd
Complexdeath receptor ligandsTnf, Tnfsf10 (Trail), Faslg (FasL)
Proteindeath receptorsTnfsfr1a (Tnf-R1), TNFRSF10A (Trail-R1, human), Tnfrsf10b (Trail-R2), Fas
Proteinadapter2Tradd

Pathway Gene Annotations

Disease Annotations Associated with Genes in the extrinsic apoptotic pathway
Disease TermsGene Symbols
Acute Kidney InjuryFas
Acute Lung InjuryFas , Faslg
AdenocarcinomaCasp8
Adenocarcinoma of EsophagusFas
Alzheimer DiseaseCasp3 , Fas
Amyotrophic Lateral SclerosisCasp3
Anemia, AplasticFas , Faslg
AnoxiaCasp3
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisFas
Aortic Aneurysm, ThoracicFas
ArteriosclerosisFaslg
Arthritis, ExperimentalFaslg
Arthritis, RheumatoidCasp7 , Fas , Faslg
AsthmaFas
AtherosclerosisFaslg
Autoimmune DiseasesCasp8 , Fas
Autoimmune Lymphoproliferative SyndromeCasp8 , Fas , Faslg
Autoimmune Lymphoproliferative Syndrome, Type IAFas
Bacterial InfectionsCasp3 , Casp8
Behcet SyndromeFas
Biliary Tract NeoplasmsFaslg
Brain Diseases, MetabolicFas
Brain InjuriesCasp3 , Casp8 , Fas
Brain IschemiaCasp3 , Fas , Faslg
Breast NeoplasmsCasp3 , Casp7 , Casp8 , Fas , Faslg
BurnsCasp3
CalcinosisCasp3
Carcinoma, HepatocellularCasp8
Carcinoma, LobularFaslg
Carcinoma, Non-Small-Cell LungCasp8 , Faslg
Carcinoma, Pancreatic DuctalFaslg
Carcinoma, Renal CellCasp3 , Fas , Faslg
Carcinoma, Squamous CellFas
Carcinoma, Squamous Cell of Head and NeckCasp8
Carcinoma, Transitional CellCasp3 , Fas , Faslg
CardiomyopathiesFas , Faslg
Cardiomyopathy, DilatedFas , Faslg
Cardiomyopathy, HypertrophicCasp3
Carotid Artery DiseasesFaslg
Carotid StenosisFaslg
CataractFas
Cerebral HemorrhageCasp3 , Casp8
Cervical Intraepithelial NeoplasiaFaslg
Chest TraumaFas
CholangiocarcinomaFaslg
Chronic UveitisFas
ClonorchiasisFas , Faslg
Colitis, ExperimentalFas
Colonic NeoplasmsFas
Colorectal NeoplasmsCasp8
Conjunctivitis, ChronicFas
Copper-Overload CirrhosisCasp3
Corneal NeovascularizationFas
CryptorchidismCasp3
Dermatitis, Allergic ContactCasp8
Dermatitis, ContactCasp8
DermatomyositisFas
Diabetes Mellitus, ExperimentalCasp3 , Casp8 , Fas , Faslg
Diabetes Mellitus, Type 1Casp3 , Casp8 , Fas , Faslg
Diabetes Mellitus, Type 2Casp3 , Casp7 , Casp8 , Fas , Faslg
Diabetic AngiopathiesCasp3 , Fas , Faslg
Diabetic NephropathiesCasp3 , Fas , Faslg
Diabetic NeuropathiesCasp3
Diabetic RetinopathyCasp3
Disease Models, AnimalFas
Drug HypersensitivityFaslg
Drug-Induced Liver InjuryCasp8 , Fas
EdemaCasp3 , Casp8
Encephalomyelitis, Autoimmune, ExperimentalCasp3 , Casp8
EndophthalmitisFas
EndotoxemiaCasp3 , Casp7 , Fas
Erectile DysfunctionCasp3
Esophageal NeoplasmsCasp8 , Fas , Faslg
Fetal Growth RetardationCasp3
Gallbladder NeoplasmsFaslg
GlaucomaFas
GliomaFas
GlomerulonephritisFas
Graft vs Host DiseaseFas , Faslg
Graves DiseaseFas
Hashimoto DiseaseFas
Heart FailureFas
Heart Valve DiseasesCasp3
Hematologic DiseasesFas
HepatitisFaslg
Hepatitis, ChronicCasp3
Heroin DependenceFas
HIV InfectionsFas
HyperglycemiaCasp8
Hyperlipidemia, Familial CombinedFaslg
HyperoxiaFas
HypersplenismFas
HypertensionCasp3
HypothermiaFas , Faslg
Hypoxia-Ischemia, BrainCasp3 , Fas
Idiopathic Pulmonary FibrosisFas , Faslg
Immunologic Deficiency SyndromesCasp8
Infarction, Middle Cerebral ArteryCasp3
Infectious MononucleosisFas , Faslg
Infertility, MaleFas
Inflammatory Bowel Disease 11Casp3
Intermittent ClaudicationCasp3
Intestinal DiseasesCasp3
Ischemic Attack, TransientCasp3 , Fas
Kidney Reperfusion InjuryCasp3
LeiomyomaFaslg
Leukemia, Lymphocytic, Chronic, B-CellFas
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveFas , Faslg
Leukemia, Myeloid, AcuteCasp7 , Fas
Leukemia-Lymphoma, Adult T-CellFas
Liver Cirrhosis, ExperimentalCasp7 , Fas
Liver Failure, AcuteFas , Faslg
Liver NeoplasmsCasp8
Liver Reperfusion InjuryCasp8 , Fas
Lung NeoplasmsCasp8 , Fas , Faslg
Lung Reperfusion InjuryCasp3
Lupus Erythematosus, SystemicFas , Faslg
Lymphatic MetastasisFas
Lymphoma, Extranodal NK-T-CellFas
Lymphoma, Large B-Cell, DiffuseFas
Lymphoma, T-Cell, CutaneousFas
Lymphoproliferative DisordersFas
Macular DegenerationFas
Malaria, FalciparumFas
Mammary Neoplasms, ExperimentalCasp3 , Casp7 , Casp8 , Fas
MelanomaCasp8 , Faslg
Mixed Connective Tissue DiseaseFas
Moyamoya DiseaseFas
Multiple MyelomaFaslg
Multiple SclerosisFaslg
Multiple System AtrophyFas
Multisystemic Smooth Muscle Dysfunction SyndromeFas
Myasthenia GravisFas
Mycoplasma InfectionsCasp3
Myelodysplastic SyndromesFas , Faslg
Myocardial InfarctionCasp3
Myocardial Reperfusion InjuryCasp3 , Casp7 , Casp8 , Fas
Nasal PolypsFas
NecrosisFas , Faslg
Neoplasm MetastasisCasp3 , Fas , Faslg
NephritisFas
Nephrosis, Puromycin AminonucleosideFas
Nerve DegenerationCasp3
Nervous System DiseasesCasp3
Neurotoxicity SyndromesCasp3
Non-alcoholic Fatty Liver DiseaseFas
Ocular HypertensionFas
Osteoarthritis, Temporomandibular JointFas
Ovarian NeoplasmsFas
Pancreatic NeoplasmsCasp8 , Faslg
PancreatitisCasp3
Pancreatitis, Acute NecrotizingCasp3
Papillomavirus InfectionsCasp8
Parkinson DiseaseFaslg
Peripheral Vascular DiseasesFas
Precursor Cell Lymphoblastic Leukemia-LymphomaCasp8 , Fas
Pregnancy Complications, CardiovascularFas
Prostatic NeoplasmsCasp3 , Fas , Faslg
ProteinuriaFas
Purpura, Thrombocytopenic, IdiopathicFas
Radiation Injuries, ExperimentalFas
Reperfusion InjuryCasp3 , Casp7 , Casp8 , Fas
Retinal DetachmentCasp3 , Fas
Retinal DiseasesCasp3
Retinitis PigmentosaCasp7
RetinoblastomaFas
Salivary Gland DiseasesCasp3
SeizuresFas
SeminomaFas , Faslg
SepsisCasp3 , Casp8 , Fas , Faslg
Sjogren's SyndromeFas
Skin NeoplasmsCasp8
Spinal Cord CompressionFas
Spinal Cord InjuriesCasp3 , Fas
Spinocerebellar AtaxiasCasp7
Status EpilepticusCasp3 , Casp8
Stomach NeoplasmsCasp8
StrokeCasp3
Subarachnoid HemorrhageCasp3
Substance-Related DisordersFaslg
Taste DisordersFas
Testicular DiseasesFaslg
Testicular InjuryFas
Urinary Bladder NeoplasmsCasp3 , Fas , Faslg
Uterine Cervical NeoplasmsCasp3 , Casp8 , Faslg
Uveitis, Autoimmune, ExperimentalFas
VaricoceleFas
Ventricular Dysfunction, LeftFas
VitiligoCasp7
Pathway Annotations Associated with Genes in the extrinsic apoptotic pathway
Pathway TermsGene Symbols
allograft rejection pathwayFas , Faslg
Alzheimer disease pathwayCasp3 , Casp7 , Casp8 , Fas
amyotrophic lateral sclerosis disease pathwayCasp3
apoptotic cell death pathwayCasp3 , Casp7 , Casp8 , Fas , Faslg
autoimmune thyroid disease pathwayFas , Faslg
ceramide signaling pathwayCasp8
colorectal cancer pathwayCasp3
cytokine mediated signaling pathwayFas , Faslg
Entamoeba histolyca infection pathwayCasp3
extrinsic apoptotic pathwayCasp3 , Casp7 , Casp8 , Fas , Faslg
FasL mediated signaling pathwayCasp3 , Casp7 , Casp8 , Fas , Faslg
glutathione metabolic pathwayCasp7
glutathione synthase deficiency pathwayCasp7
glutathionuria disease pathwayCasp7
graft-versus-host disease pathwayFas , Faslg
Huntington disease pathwayCasp3 , Casp8
influenza A virus infection pathwayFas , Faslg
interleukin-12 signaling pathwayFaslg
intrinsic apoptotic pathwayCasp3 , Casp7 , Fas
measles infection pathwayFas , Faslg
mitogen activated protein kinase signaling pathwayCasp3 , Fas , Faslg
Mycobacterium tuberculosis infection pathwayCasp3 , Casp8
myocarditis pathwayCasp3 , Casp8
neurotrophic factor signaling pathwayFaslg
NOD-like receptor signaling pathwayCasp8
p53 signaling pathwayCasp3 , Casp8 , Fas
Parkinson disease pathwayCasp3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8
syndecan signaling pathwayCasp3
titanium dioxide nanoparticle response pathwayCasp3 , Casp8 , Fas
Toll-like receptor signaling pathwayCasp8
Toxoplasma gondii infection pathwayCasp3 , Casp8
Trail mediated signaling pathwayCasp3 , Casp7 , Casp8
Trypanosoma brucei infection pathwayFas , Faslg
Trypanosoma cruzi infection pathwayCasp8 , Fas , Faslg
tumor necrosis factor mediated signaling pathwayCasp8
type 1 diabetes mellitus pathwayFas , Faslg
Phenotype Annotations Associated with Genes in the extrinsic apoptotic pathway
Phenotype TermsGene Symbols
neurodegenerationFaslg

References Associated with the extrinsic apoptotic pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: