INTRINSIC APOPTOTIC PATHWAY (PW:0000104)

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Description

Apoptosis, or programmed cell death, removes excess or damaged cells to maintain tissue homeostasis. The two major apoptotic pathways, the extrinsic, triggered by ligands activating the death receptors and the intrinsic (mitochondrial), triggered by intracellular stresses, converge on the activation of executioner caspases. In the intrinsic pathway, the Bcl-2 family of pro- and anti-apoptotic proteins controls the life-to-death switch. Structurally, they share the Bcl homology BH domain. Most pr

Pathway Diagram:

Ariadne Genomics Inc. caspase targets pro-survival Bcl BH3-only Bcl Bax Casp3 ---> caspase targets Casp7 ---> caspase targets Casp3 ---> caspase targets Casp7 ---> caspase targets Casp9 ---> Casp7 Casp9 ---> Casp3 Casp9 ---- Xiap Htra2 ---> released_Htra2 released_Diablo ---- Xiap Casp3 ---- Xiap Casp7 ---- Xiap BH3-only Bcl ---- pro-survival Bcl Apaf1 ---- released_Cycs Diablo ---> released_Diablo Apaf1 ---- Casp9 Cycs ---> released_Cycs released_Htra2 ---> Xiap intracellular stresses Bok ---- pro-survival Bcl Bax ---- pro-survival Bcl Bak1 ---- pro-survival Bcl released_Diablo released_Htra2 Bak1 Bok Htra2 Diablo Xiap Casp3 Casp7 intracellular stresses --+> BH3-only Bcl BH3-only Bcl ---| pro-survival Bcl pro-survival Bcl ---| Bak1 pro-survival Bcl ---| Bax pro-survival Bcl ---| Bok apoptosome --+> Casp9 released_Htra2 ---| Xiap released_Diablo ---| Xiap Xiap ---| Casp7 Xiap ---| Casp3 Casp9 --+> Casp3 Casp9 --+> Casp7 Xiap ---| Casp9 Apaf1 released_Cycs ATP dATP Cycs apoptosome Casp9
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Genes in Pathway:

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intrinsic apoptotic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:2313998
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:1579966
RGD:2314029
G Bad_v1 BCL2-associated agonist of cell death, variant 1 RGD:1579966
G Bad_v2 BCL2-associated agonist of cell death, variant 2 RGD:1579966
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:2313963
RGD:2313975
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1579966
RGD:2313963
RGD:2313975
RGD:2313998
RGD:2314140
G Bax_v1 BCL2 associated X, apoptosis regulator, variant 1 RGD:1579966
G Bax_v2 BCL2 associated X, apoptosis regulator, variant 2 RGD:1579966
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:2313994
RGD:2314029
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1579966
RGD:2313975
RGD:2313998
RGD:2314140
G Bcl2a1 BCL2-related protein A1 JBrowse link 8 96,551,424 96,559,527 RGD:2313975
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:1579966
RGD:2313975
RGD:2314140
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:2314029
G Bcl2l2 Bcl2-like 2 JBrowse link 15 33,543,774 33,549,165 RGD:2313963
RGD:2313975
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:2313998
RGD:2314002
RGD:2314029
G Bik BCL2-interacting killer JBrowse link 7 124,390,924 124,410,449 RGD:2314029
G Bmf Bcl2 modifying factor JBrowse link 3 110,303,515 110,324,125 RGD:2314029
G Bnip1 BCL2 interacting protein 1 JBrowse link 10 16,677,077 16,689,321 RGD:634759
RGD:2314029
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:2314028
RGD:2314029
G Bnip3l BCL2 interacting protein 3 like JBrowse link 15 43,643,897 43,667,123 RGD:2314029
G Bok BOK, BCL2 family apoptosis regulator JBrowse link 9 100,829,593 100,840,498 RGD:70678
RGD:2313975
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:71121
RGD:2313963
RGD:2313998
RGD:2314002
RGD:2314187
RGD:2314390
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:2314187
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:2313963
RGD:2313998
RGD:2314002
RGD:2314187
RGD:2314390
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:2313963
RGD:2313998
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:1626509
G Hrk harakiri, BCL2 interacting protein JBrowse link 12 44,008,879 44,029,211 RGD:70327
RGD:2290488
RGD:2314029
G Htra2 HtrA serine peptidase 2 JBrowse link 4 113,883,671 113,886,833 RGD:2314385
G Mcl1 MCL1, BCL2 family apoptosis regulator JBrowse link 2 197,786,212 197,788,992 RGD:70678
RGD:2313975
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:2314029
RGD:2314140
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:2314390

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Groupcaspase targetsseveral genes identified as caspase substrates
Functional Classpro-survival Bclthe members of the Bcl family that are anti-apoptotic
Functional ClassBH3-only Bclthe members of the pro-apoptotic Bcl family with only the BH3 domain

Pathway Gene Annotations

Disease Annotations Associated with Genes in the intrinsic apoptotic pathway
Disease TermsGene Symbols
3-METHYLGLUTACONIC ACIDURIA, TYPE VIIIHtra2
Acute Kidney InjuryBad , Bax , Bcl2 , Bcl2l1 , Fas
Acute Lung InjuryBax , Bcl2 , Fas
AdenocarcinomaBcl2
Adenocarcinoma of EsophagusFas
Adenocarcinoma, Clear CellBcl2
Adenocarcinoma, ColorectalBcl2l1
AdenomaBcl2 , Bcl2l1
Adrenal InsufficiencyBax , Bcl2
Aging, PrematureBax , Bcl2 , Htra2
AIDS-related Kaposi SarcomaBcl2
Alzheimer DiseaseBad , Bak1 , Bax , Bcl2 , Bcl2l1 , Casp3 , Fas , Htra2
Amyotrophic Lateral SclerosisCasp3 , Casp9
Amyotrophic Lateral Sclerosis 1Bcl2l1 , Xiap
Anemia, AplasticFas
AnoxiaCasp3
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisFas
Aortic Aneurysm, ThoracicFas
Arthritis, ExperimentalBax , Bcl2
Arthritis, RheumatoidBcl2a1 , Casp7 , Fas
Asphyxia NeonatorumHtra2
AsthmaBcl2 , Fas
Autistic DisorderBcl2
Autoimmune DiseasesFas
Autoimmune Lymphoproliferative SyndromeFas
Autoimmune Lymphoproliferative Syndrome, Type IAFas
AzoospermiaBcl2
B-Cell CLL/Lymphoma 2Bcl2
Bacterial InfectionsCasp3 , Casp9
Barrett EsophagusFas , Mcl1
Behcet SyndromeFas
Brain Diseases, MetabolicFas
Brain InjuriesApaf1 , Bad , Bax , Bcl2 , Casp3 , Fas
Brain IschemiaApaf1 , Bad , Bbc3 , Bcl2 , Bcl2l1 , Casp3 , Casp9 , Cycs , Fas
Breast NeoplasmsBad , Bax , Bcl2 , Bcl2a1 , Bcl2l1 , Casp3 , Casp7 , Casp9 , Fas , Xiap
Burkitt LymphomaBbc3
BurnsBad , Bax , Bcl2 , Casp3
CalcinosisCasp3
CarcinomaBcl2 , Bcl2l1
Carcinoma, Ductal, BreastHtra2
Carcinoma, HepatocellularBcl2l1 , Bid
Carcinoma, Intraductal, NoninfiltratingBcl2 , Bnip3
Carcinoma, Renal CellApaf1 , Bad , Bak1 , Bcl2 , Bcl2l1 , Casp3 , Fas , Xiap
Carcinoma, Squamous CellBcl2 , Fas
Carcinoma, Transitional CellApaf1 , Bcl2 , Bcl2l1 , Casp3 , Fas
CardiomegalyBad
CardiomyopathiesFas , Htra2
Cardiomyopathy, DilatedBax , Fas
Cardiomyopathy, HypertrophicBcl2 , Casp3
CataractFas
Cell Transformation, NeoplasticBcl2
Cerebral HemorrhageBax , Bcl2 , Bcl2l1 , Bnip3l , Casp3
Cervical Intraepithelial NeoplasiaBcl2 , Xiap
Chest TraumaFas
ChloracneCycs
CholangiocarcinomaCycs
Cholangitis, SclerosingBcl2l11
Chondrosarcoma, MesenchymalBcl2
ChorioamnionitisFas
Chronic Cerebral HypoperfusionBnip3l
Chronic Intermittent HypoxiaBnip3
Chronic UveitisFas
ClonorchiasisFas
Colitis, ExperimentalFas
Colonic NeoplasmsBad , Bak1 , Bax , Bcl2 , Fas
Colorectal NeoplasmsBax , Bcl2
Conjunctivitis, ChronicFas
Copper-Overload CirrhosisCasp3
Corneal NeovascularizationFas
Craniofacial AbnormalitiesApaf1
CryptorchidismBcl2l1 , Casp3 , Htra2
Cystic FibrosisFas
DementiaBax , Bcl2
Dementia, Multi-InfarctBax , Bcl2
Depressive DisorderBax , Bcl2l1
Dermatitis, Allergic ContactBcl2
Dermatitis, ContactBcl2
DermatomyositisFas
Diabetes Mellitus, ExperimentalBad , Bax , Bcl2 , Bcl2l1 , Casp3 , Casp9 , Fas
Diabetes Mellitus, Type 1Casp3 , Casp9 , Fas
Diabetes Mellitus, Type 2Bad , Bax , Bcl2 , Bcl2l1 , Casp3 , Casp7 , Casp9 , Fas
Diabetes, GestationalBnip3l
Diabetic AngiopathiesCasp3 , Fas
Diabetic CardiomyopathiesBad , Bcl2
Diabetic CystopathyBad
Diabetic NephropathiesCasp3 , Fas
Diabetic NeuropathiesBad , Casp3
Diabetic RetinopathyCasp3 , Casp9
Disease Models, AnimalFas
Disease ProgressionBcl2
Drug-Induced Liver InjuryBad , Bax , Fas
EdemaCasp3 , Casp9
Encephalomyelitis, Autoimmune, ExperimentalCasp3 , Casp9
Endometrial NeoplasmsBcl2 , Bcl2l1 , Htra2
EndometriosisBax , Bcl2 , Bcl2l1
EndophthalmitisFas
EndotoxemiaBax , Bcl2 , Casp3 , Casp7 , Fas
Enterocolitis, NecrotizingBnip3
Erectile DysfunctionBad , Bax , Bcl2 , Bcl2l1 , Casp3
Esophageal NeoplasmsBax , Bbc3 , Bcl2 , Bcl2a1 , Fas , Xiap
Eye AbnormalitiesApaf1
Fatty LiverCycs
Fetal Growth RetardationBax , Bcl2 , Casp3 , Fas
Gallbladder NeoplasmsBcl2
Gastrointestinal HemorrhageBax
GlaucomaBad , Bax , Bcl2 , Fas
GliomaBad , Fas
GlomerulonephritisBax , Bcl2 , Bcl2l11 , Fas
Graft vs Host DiseaseFas
Graves DiseaseFas
Hashimoto DiseaseFas
Head and Neck NeoplasmsBcl2 , Bcl2l1
Hearing LossBcl2l1
Heart DiseasesBax , Casp9
Heart FailureBax , Bcl2 , Bnip3 , Fas
Heart Valve DiseasesCasp3
Hematologic DiseasesBcl2l1 , Fas
HemorrhageBnip3
Hepatitis, ChronicCasp3
Heroin DependenceFas
HIV InfectionsBax , Fas
Huntington DiseaseBax , Bcl2 , Fas , Htra2
HydrocephalusBok
HyperbilirubinemiaBcl2
HyperoxiaBnip3 , Fas
HyperplasiaBax
HypersensitivityBcl2a1
HypersplenismFas
HypertensionBad , Bax , Bcl2 , Casp3
Hypertension, PulmonaryBcl2 , Bcl2l1
Hypertrophy, Left VentricularBak1
HypothermiaBcl2 , Fas
HypothyroidismBad
Hypoxia-Ischemia, BrainBax , Bcl2 , Bcl2l1 , Casp3 , Fas
Idiopathic Pulmonary FibrosisFas
Infarction, Middle Cerebral ArteryBad , Bax , Bcl2 , Bnip3 , Bnip3l , Casp3 , Htra2
Infectious MononucleosisFas
Infertility, FemaleHtra2
Infertility, MaleBax , Bcl2 , Fas
Inflammatory Bowel Disease 11Casp3
Insulin ResistanceBad
Intermittent ClaudicationBad , Bak1 , Bax , Bbc3 , Casp3
Intestinal DiseasesBax , Bcl2 , Casp3
Intestinal NeoplasmsBax , Bcl2
Intracranial AneurysmBcl2
IschemiaBax , Cycs
Ischemic Attack, TransientBad , Bax , Bbc3 , Bcl2 , Bnip3 , Casp3 , Casp9 , Cycs , Fas , Htra2
Kashin-Beck DiseaseBax , Bcl2 , Fas
Kidney Failure, ChronicBcl2 , Bnip3
Kidney Reperfusion InjuryBax , Bcl2 , Bnip3 , Casp3
Learning DisordersBcl2
LeiomyomaBak1 , Bax , Bcl2 , Bcl2l1
LeishmaniasisMcl1
LeukemiaBad
Leukemia, Lymphocytic, Chronic, B-CellBcl2 , Bmf , Fas , Pmaip1
Leukemia, LymphoidBcl2l1
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveBcl2l1 , Fas
Leukemia, Myeloid, AcuteBcl2 , Bcl2l1 , Casp7 , Fas
Leukemia-Lymphoma, Adult T-CellFas
Leukoplakia, OralBcl2
Liver Cirrhosis, AlcoholicBcl2
Liver Cirrhosis, ExperimentalApaf1 , Bak1 , Bcl2 , Bmf , Casp7 , Fas
Liver DiseasesBcl2l1
Liver Failure, AcuteFas
Liver Neoplasms, ExperimentalBcl2 , Bcl2l1
Liver Reperfusion InjuryBad , Bax , Bcl2 , Bcl2l1 , Fas
Lung NeoplasmsBcl2l1 , Fas , Mcl1
Lung Reperfusion InjuryBax , Bcl2 , Casp3
Lupus Erythematosus, SystemicFas
Lymphatic MetastasisBcl2 , Fas
Lymphoma, Extranodal NK-T-CellFas
Lymphoma, FollicularBcl2
Lymphoma, Large B-Cell, DiffuseBcl2 , Fas
Lymphoma, Non-HodgkinBcl2
Lymphoma, T-Cell, CutaneousBax , Fas , Mcl1
Lymphoproliferative DisordersFas , Xiap
Lymphoproliferative Syndrome, X-Linked, 2Xiap
Macular DegenerationBad , Bax , Fas
Malaria, FalciparumFas
Mammary Neoplasms, ExperimentalApaf1 , Bad , Bak1 , Bax , Bcl2 , Bcl2l1 , Casp3 , Casp7 , Casp9 , Fas , Xiap
Manganese PoisoningBnip3
MelanomaBcl2 , Bcl2l1 , Fas
Memory DisordersBcl2
Mesothelioma, MalignantBcl2
MetaplasiaBcl2
Methylmalonic AcidemiaCycs
Microsatellite InstabilityBax
Mixed Connective Tissue DiseaseFas
Morphine DependenceBax , Bcl2
Motor Neuron DiseaseHtra2
Moyamoya DiseaseFas
Multiple MyelomaBcl2 , Bcl2l1 , Bnip3 , Mcl1
Multiple SclerosisFas
Multiple Sclerosis, Relapsing-RemittingFas
Multiple System AtrophyFas
Multisystemic Smooth Muscle Dysfunction SyndromeFas
Muscular AtrophyApaf1
Myasthenia GravisFas
Mycoplasma InfectionsCasp3
Myelodysplastic SyndromesFas
Myocardial InfarctionBax , Bcl2 , Bcl2l1 , Bnip3 , Casp3
Myocardial IschemiaBax , Bcl2
Myocardial Reperfusion InjuryBad , Bax , Bcl2 , Bcl2l1 , Bid , Bnip3 , Casp3 , Casp7 , Casp9 , Fas , Htra2 , Xiap
Myositis, Inclusion BodyFas
Nasal PolypsFas
Nasopharyngeal CarcinomaBcl2
NecrosisBcl2 , Fas
Neoplasm MetastasisBax , Bcl2 , Casp3 , Fas
Neoplasms, Plasma CellBcl2l1
NephritisFas
Nephritis, InterstitialBax
Nephrosis, Puromycin AminonucleosideFas
Nerve DegenerationBak1 , Bax , Bcl2 , Casp3
Nervous System DiseasesCasp3 , Casp9
Neurotoxicity SyndromesBcl2l1 , Casp3
Non-alcoholic Fatty Liver DiseaseFas
ObesityBad , Bcl2 , Bnip3 , Cycs
Ocular HypertensionBcl2l1 , Fas
Optic Nerve InjuriesBax , Bcl2
OsteoarthritisBad , Bax , Bcl2
Osteoarthritis, KneeBax , Bcl2
Osteoarthritis, Temporomandibular JointFas
OsteochondrodysplasiasBcl2
OsteoporosisBax , Bcl2
Ovarian NeoplasmsBcl2 , Bcl2l1 , Fas , Htra2 , Xiap
Oxygen-Induced RetinopathyFas
Pancreatic NeoplasmsApaf1 , Bcl2l1 , Bid , Cycs
PancreatitisBnip3l , Casp3
Pancreatitis, Acute NecrotizingCasp3
Pancreatitis, ChronicBad
Pancreatitis, Experimental, Acute Bcl2l1
Parkinson DiseaseFas , Htra2
Parkinson Disease 13Htra2
Parkinsonian DisordersBad , Htra2
Peripheral Nervous System DiseasesCasp9
Peripheral Vascular DiseasesFas
PlasmacytomaBcl2
Pleomorphic Xanthoastrocytoma Cycs
Polycystic Ovary SyndromeBax , Bcl2
Polycythemia VeraBcl2l1
Pre-EclampsiaFas
Precursor B-Cell Lymphoblastic Leukemia-LymphomaBcl2l1
Precursor Cell Lymphoblastic Leukemia-LymphomaBcl2 , Bcl2l1 , Fas
Precursor T-Cell Lymphoblastic Leukemia-LymphomaBax , Bcl2
Pregnancy Complications, CardiovascularFas
PriapismBcl2
Prostatic HyperplasiaBad
Prostatic NeoplasmsBad , Bax , Bcl2 , Bcl2l1 , Bnip3 , Casp3 , Casp9 , Fas , Htra2 , Xiap
ProteinuriaFas
Pulmonary Disease, Chronic ObstructiveBcl2l1 , Bnip3
Pulmonary FibrosisBad
Purpura, Thrombocytopenic, IdiopathicFas
Radiation Injuries, ExperimentalFas
Reperfusion InjuryApaf1 , Bad , Bax , Bcl2 , Bid , Casp3 , Casp7 , Casp9 , Fas
Retina Reperfusion InjuryBad , Bax , Bcl2 , Bcl2l1
Retinal DegenerationBax , Bcl2
Retinal DetachmentApaf1 , Bnip3 , Casp3 , Casp9 , Fas
Retinal DiseasesCasp3
Retinitis PigmentosaCasp7
RetinoblastomaFas
Rhinitis, AllergicBcl2
Salivary Gland DiseasesCasp3
SarcomaMcl1
Sarcoma, SynovialBcl2
SarcopeniaBax , Bcl2
Scleroderma, LimitedFas
SeizuresApaf1 , Bad , Fas
SeminomaFas
SepsisBad , Casp3 , Fas , Htra2
Shock, HemorrhagicBad , Bcl2 , Bcl2l1
Sjogren's SyndromeFas
Skin AbnormalitiesApaf1
Small-For-Size SyndromeBad
Soft Tissue NeoplasmsBcl2
Spinal Cord CompressionFas
Spinal Cord InjuriesBnip3 , Bnip3l , Casp3 , Fas
Spinal Cord Reperfusion InjuryBad
Spinocerebellar AtaxiasCasp7
SplenomegalyHtra2
Status EpilepticusBax , Bcl2 , Bcl2l1 , Casp3 , Htra2
Stomach NeoplasmsBcl2l1 , Bid , Bnip3 , Htra2
Stomach UlcerBad , Bcl2 , Bcl2l1
Stress Disorders, Post-TraumaticBax , Bcl2
StrokeBcl2l1 , Casp3
Subarachnoid HemorrhageBnip3 , Casp3
Substance-Related DisordersPmaip1
Taste DisordersFas
TeratomaBax
Testicular InjuryFas
ThrombocytopeniaCycs
Thrombocytopenia 4Cycs
ThyroiditisBax
Tongue NeoplasmsBcl2
ToxoplasmosisBax
Urinary Bladder NeoplasmsBax , Bcl2 , Bcl2l1 , Casp3 , Casp9 , Fas
Uterine Cervical NeoplasmsBak1 , Bax , Bcl2l1 , Casp3 , Xiap
Uterine NeoplasmsBcl2l1
Uveitis, Autoimmune, ExperimentalFas
VaricoceleCasp9 , Fas
Ventricular Dysfunction, LeftFas
VitiligoCasp7
Wilms TumorBcl2l1
Pathway Annotations Associated with Genes in the intrinsic apoptotic pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayBad
adenosine signaling pathwayBad
allograft rejection pathwayFas
Alzheimer disease pathwayApaf1 , Bad , Bid , Casp3 , Casp7 , Casp9 , Cycs , Fas
amyotrophic lateral sclerosis disease pathwayApaf1 , Bad , Bax , Bcl2 , Bcl2l1 , Bid , Casp3 , Casp9 , Cycs
apoptotic cell death pathwayApaf1 , Bad , Bax , Bcl2 , Bcl2l1 , Bid , Casp3 , Casp7 , Casp9 , Cycs , Fas , Xiap
autoimmune thyroid disease pathwayFas
Bone morphogenetic proteins signaling pathwayXiap
cardiolipin metabolic pathwayCycs
ceramide signaling pathwayBad , Bax , Bcl2 , Bcl2l1 , Bid , Casp9 , Cycs
chronic myeloid leukemia pathwayBad , Bcl2l1
colorectal cancer pathwayBad , Bax , Bcl2 , Casp3 , Casp9 , Cycs
cytokine mediated signaling pathwayFas
electron transport chain pathwayCycs
endometrial cancer pathwayBad , Casp9
Endoplasmic Reticulum-associated degradation pathwayBak1 , Bax , Bcl2
Entamoeba histolyca infection pathwayCasp3
epidermal growth factor/neuregulin signaling pathwayBad
erythropoietin signaling pathwayBcl2 , Bcl2l1
extrinsic apoptotic pathwayCasp3 , Casp7 , Fas
FasL mediated signaling pathwayBid , Casp3 , Casp7 , Fas
glutathione metabolic pathwayCasp7
glutathione synthase deficiency pathwayCasp7
glutathionuria disease pathwayCasp7
graft-versus-host disease pathwayFas
hepatitis C virus infection pathwayBad
Huntington disease pathwayApaf1 , Bax , Bbc3 , Casp3 , Casp9 , Cycs
hypoxia inducible factor pathwayBnip3 , Mcl1
influenza A virus infection pathwayCasp9 , Cycs , Fas
insulin signaling pathwayBad
insulin-like growth factor signaling pathwayBad
interleukin-2 signaling pathwayBcl2
interleukin-3 signaling pathwayBcl2l1
interleukin-6 signaling pathwayMcl1
intrinsic apoptotic pathwayApaf1 , Bad , Bad_v1 , Bad_v2 , Bak1 , Bax , Bax_v1 , Bax_v2 , Bbc3 , Bcl2 , Bcl2a1 , Bcl2l1 , Bcl2l11 , Bcl2l2 , Bid , Bik , Bmf , Bnip1 , Bnip3 , Bnip3l , Bok , Casp3 , Casp7 , Casp9 , Cycs , Fas , Hrk , Htra2 , Mcl1 , Pmaip1 , Xiap
Jak-Stat signaling pathwayBcl2l1
measles infection pathwayBbc3 , Fas
melanoma pathwayBad
mitochondrial autophagy pathwayBnip3 , Bnip3l
mitogen activated protein kinase signaling pathwayCasp3 , Fas
mTOR signaling pathwayBnip3 , Cycs
Mycobacterium tuberculosis infection pathwayApaf1 , Bad , Bax , Bcl2 , Bid , Casp3 , Casp9 , Cycs
myocarditis pathwayBid , Casp3 , Casp9 , Cycs
neurotrophic factor signaling pathwayBad , Bax , Bcl2
NOD-like receptor signaling pathwayXiap
non-small cell lung cancer pathwayBad , Casp9
p53 signaling pathwayApaf1 , Bax , Bbc3 , Bid , Casp3 , Casp9 , Cycs , Fas , Pmaip1
pancreatic cancer pathwayBad , Bcl2l1 , Casp9
Parkinson disease pathwayApaf1 , Casp3 , Casp9 , Cycs , Htra2
phosphatidylinositol 3-kinase-Akt signaling pathwayBad , Casp9
prion diseases pathwayBax
prostate cancer pathwayBad , Bcl2 , Casp9
small cell lung cancer pathwayApaf1 , Bcl2 , Bcl2l1 , Casp9 , Cycs , Xiap
syndecan signaling pathwayBax , Casp3
titanium dioxide nanoparticle response pathwayBax , Casp3 , Fas
Toxoplasma gondii infection pathwayBad , Bcl2 , Bcl2l1 , Casp3 , Casp9 , Cycs , Xiap
Trail mediated signaling pathwayBid , Casp3 , Casp7
transforming growth factor-beta Smad dependent signaling pathwayXiap
Trypanosoma brucei infection pathwayFas
Trypanosoma cruzi infection pathwayFas
type 1 diabetes mellitus pathwayFas
ubiquitin/proteasome degradation pathwayXiap
vascular endothelial growth factor signaling pathwayBad , Casp9
Phenotype Annotations Associated with Genes in the intrinsic apoptotic pathway

References Associated with the intrinsic apoptotic pathway:

Ontology Path Diagram:

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Import into Pathway Studio: