THE EXTRACELLULAR SIGNAL-REGULATED RAF/MEK/ERK SIGNALING PATHWAY (PW:0000102)

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Description

The extracellular signal regulated MAP kinase pathway (Raf/Mek/Erk) couples signals reverberating from activated cell surface receptors via their downstream effectors, to many cytoplasmic and nuclear targets. Raf/Mek/Erk displays the characteristic three-tier core cascade MAPK architecture. The downstream and effector MAPK tier (here Erk represented by Mapk1 and 3) is activated by phosphorylation of threonine and tyrosine residues within the conserved TEY motif in the activation loop by d

Pathway Diagram:

Ariadne Genomics Inc. Mapk1 Pp2a Dusp6 Map2k2 Map2k1 Erk cytoplasmic/other targets Ksr1 Ksr2 Raf members upstream Ras RTK, others effectors/adapters Erk nuclear targets Erk activated MAPKAPK Pebp1 ---- Raf members Pebp1 ---| Raf members Pebp1 Raf members --+> Map2k2 Raf members --+> Map2k1 Pp2a --+> Raf members Pp2a ---| Map2k2 upstream Ras --+> Raf members effectors/adapters <--> upstream Ras Mapk3 Mapk1 ---> Erk nuclear targets Mapk3 ---> Erk cytoplasmic/other targets Mapk1 ---> Erk cytoplasmic/other targets Mapk3 ---> Erk nuclear targets effectors/adapters ---- RTK, others Ptprr ---| Mapk1 Map2k2 --+> Mapk3 Map2k1 --+> Mapk3 Map2k1 --+> Mapk1 Map2k2 --+> Mapk1 Pp2a ---| Map2k1 Pp2a ---| Mapk1 Pp2a ---| Mapk3 Dusp6 ---| Mapk1 Dusp6 ---| Mapk3 Ptprr ---| Mapk3 Mapk1 --+> Erk activated MAPKAPK Mapk3 --+> Erk activated MAPKAPK Ksr2 ---- Map2k1 Ksr1 ---- Map2k2 Ksr2 ---- Map2k2 Ksr1 ---- Raf members Ptprr
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Genes in Pathway:

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the extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Araf A-Raf proto-oncogene, serine/threonine kinase JBrowse link X 1,369,534 1,391,603 RGD:5686410
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:1580106
RGD:5686410
RGD:1626216
G Dusp6 dual specificity phosphatase 6 JBrowse link 7 41,475,163 41,479,393 RGD:2293881
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:5686410
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:628557
RGD:5686410
G Ksr1 kinase suppressor of ras 1 JBrowse link 10 66,323,704 66,342,469 RGD:2293880
RGD:5686410
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:70317
RGD:1626216
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:729046
RGD:1626216
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:1357969
RGD:2293879
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:724475
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:628468
RGD:8553011
RGD:1626216
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:628468
RGD:8553011
RGD:1626216
G Mknk1 MAP kinase-interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:2315047
RGD:8553011
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 JBrowse link 7 11,908,107 11,919,161 RGD:2315047
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:5686410
G Pebp1 phosphatidylethanolamine binding protein 1 JBrowse link 12 45,026,948 45,031,148 RGD:2293882
RGD:2302807
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:1642529
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1642630
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:70317
RGD:5686410
RGD:1626216
RGD:1580106
G Rps6ka1 ribosomal protein S6 kinase A1 JBrowse link 5 152,078,217 152,122,684 RGD:2315047
G Rps6ka2 ribosomal protein S6 kinase A2 JBrowse link 1 53,219,346 53,499,445 RGD:2315047
G Rps6ka3 ribosomal protein S6 kinase A3 JBrowse link X 37,469,736 37,576,055 RGD:2315047
G Rps6ka4 ribosomal protein S6 kinase A4 JBrowse link 1 222,087,328 222,098,284 RGD:2315047
G Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link 6 124,557,892 124,735,787 RGD:2315047
G Rps6ka6 ribosomal protein S6 kinase A6 JBrowse link X 82,641,679 82,743,771 RGD:2315047
G S1pr1 sphingosine-1-phosphate receptor 1 JBrowse link 2 218,654,406 218,658,761 RGD:1304283
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:1643182
G Smad1 SMAD family member 1 JBrowse link 19 32,182,942 32,248,694 RGD:1643230
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:1581337
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1580097
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:2293882
RGD:5133243
RGD:5133242
RGD:2298531
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:2306732
RGD:5490966
RGD:5490965
RGD:5133242
RGD:4143515
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:5133242
RGD:5133243
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:2293882

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ComplexPp2a complex
Functional Classupstream Ras
Functional ClassRaf members
Gene GroupErk nuclear targets
Gene GroupErk cytoplasmic/other targets
Functional ClassErk activated MAPKAPKadditional kinase tier that furthers the signal
Functional ClassRTK, othersupstream pathways that trigger Raf/Mek/Erk via receptor tyrosine kinases and other receptors

Pathway Gene Annotations

Disease Annotations Associated with Genes in the the extracellular signal-regulated Raf/Mek/Erk signaling pathway
Disease TermsGene Symbols
46,XY Sex Reversal 6Map3k1
Aberrant Crypt FociMapk1 , Mapk3
Abnormalities, MultipleKras , Mapk1
Acute Kidney InjurySpp1
AdenocarcinomaKras , Spp1
Adenocarcinoma of LungAraf , Braf , Hras , Kras , Map2k1 , Nras , Raf1
ADENOCARCINOMA OF STOMACHBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1
Adenocarcinoma, Bronchiolo-AlveolarKras
Adenocarcinoma, ColonMapk1 , Mapk3
Adenocarcinoma, ColorectalMapk1 , Mapk3 , Raf1
Adenocarcinoma, FollicularKras
Adenocarcinoma, ProstaticBraf , Hras , Map2k1
AdenomaKras
Adenoma, ColorectalRaf1
Adenoma, Liver CellHras , Kras
Adrenocortical CarcinomaBraf , Nras
AlbuminuriaSpp1
Alport Syndrome, Recessive TypeHras
Alzheimer DiseaseHras , Pebp1 , Shc1 , Tsc2
AmeloblastomaBraf
Amyotrophic Lateral Sclerosis 1Shc1
AnemiaKras
AneurysmSpp1
Angina PectorisSpp1
AngiomyolipomaTsc2
Anti-Glomerular Basement Membrane DiseasePtk2b , Spp1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arthritis, ExperimentalNras
Arthritis, JuvenileKras , Mapk1
Arthritis, RheumatoidSpp1
AsbestosisSpp1
AstrocytomaBraf , Kras
AtrophyMapk3
Autism Spectrum DisorderMapk3 , Tsc2
Autistic DisorderHras , Tsc2
Autoimmune Lymphoproliferative SyndromeNras
Autoimmune Lymphoproliferative Syndrome, Type IIIPrkcd
Autoimmune Lymphoproliferative Syndrome, Type IVKras , Nras
Benign Skin NeoplasmsHras
Biliary AtresiaSpp1
bladder carcinomaHras
bladder urothelial carcinomaBraf , Hras , Kras , Map2k1 , Nras
Bone Diseases, DevelopmentalRps6ka3
Brain DiseasesTsc2
Brain IschemiaDusp6 , Map2k1 , Mapk1 , Mapk3 , Prkcd , Ptk2b
Brain NeoplasmsSpp1
Breast AdenocarcinomaKras
breast cancerBraf , Hras
Breast NeoplasmsAraf , Braf , Dusp6 , Hras , Kras , Map2k1 , Map2k2 , Map3k1 , Mapk1 , Ptk2b , Raf1 , Spp1 , Tsc2
BurnsPrkcd
CalcinosisSpp1
CarcinogenesisBraf , Kras
CarcinomaDusp6 , Hras , Kras , Pebp1 , S1pr1
Carcinoma, Adenoid CysticHras , Map2k2
Carcinoma, EndometrioidKras , Spp1
Carcinoma, HepatocellularBraf , Hras , Kras , Nras , Rps6ka3 , Shc1 , Spp1
Carcinoma, Non-Small-Cell LungAraf , Braf , Hras , Kras , Map2k1 , Nras , Raf1 , Spp1
Carcinoma, Pancreatic DuctalKras , Tsc2
Carcinoma, Renal CellKras , Map2k1 , Nras , Pebp1 , Tsc2
Carcinoma, Squamous CellHras , Kras , Mapk1 , Mapk3 , Tsc2
Carcinoma, Squamous Cell of Head and NeckBraf , Hras , Map2k1 , Map2k2 , Mapk1
Carcinoma, Transitional CellBraf , Hras , Kras , Map2k1 , Mapk1 , Nras
Cardiofaciocutaneous SyndromeBraf , Hras , Kras , Map2k1 , Map2k2
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyMapk1 , Prkcd , Raf1 , S1pr1 , Shc1 , Spp1
CardiomyopathiesKras , Mapk1 , Mapk3
Cardiomyopathy, DilatedKras , Raf1
CARDIOMYOPATHY, DILATED, 1NNRaf1
Cardiomyopathy, Familial Hypertrophic, 4Braf
Cardiomyopathy, HypertrophicKras , Raf1
Cardiomyopathy, Hypertrophic, FamilialKras , Raf1
Cardiomyopathy, RestrictivePrkcd
Cardiovascular AbnormalitiesMap2k1
CataractMap2k1
Cecal NeoplasmsKras
Cell Transformation, NeoplasticHras , Kras
Cerebral HemorrhageSpp1
Ceroid Lipofuscinosis, Neuronal, 6Mapk1 , Mapk3
Charcot-Marie-Tooth Disease, Type 2DSmad1
Chemical and Drug Induced Liver InjurySpp1
CholangiocarcinomaKras
Chronic Lymphoid LeukemiaBraf , Hras , Kras , Nras
Cocaine-Related DisordersMapk1 , Mapk3 , Rps6ka5
Coffin-Lowry SyndromeRps6ka3
colon cancerBraf , Nras
Colonic NeoplasmsBraf , Kras , Nras
colorectal cancerBraf , Nras
Colorectal NeoplasmsBraf , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Raf1
Coronary Artery DiseaseSpp1
Coronary RestenosisMapk1 , Spp1
Costello SyndromeBraf , Hras , Kras , Map2k1 , Map2k2
CraniopharyngiomaBraf
Dermatitis, Allergic ContactSpp1
Developmental DisabilitiesRps6ka3
Diabetes Mellitus, ExperimentalHras , Mapk1 , Mapk3 , Prkcd , Smad1 , Spp1 , Tsc2
Diabetes Mellitus, Type 2Braf
Diabetic AngiopathiesPtk2b
Diabetic CardiomyopathiesSpp1
Diabetic NephropathiesMapk1 , Spp1
Diabetic RetinopathyHras
Disease Models, AnimalKras , Mapk1 , Mapk3
Disease ProgressionHras
Drug-Related Side Effects and Adverse ReactionsSpp1
Dysembryoplastic Neuroepithelial TumorBraf
EncephalomyelitisSpp1
endometrial cancerKras
endometrial carcinomaKras
Endometrial HyperplasiaKras
Endometrial NeoplasmsBraf , Kras , Mapk1 , Mapk3
EndometriosisKras
Epidermal NevusHras , Kras , Nras
EpilepsyTsc2
Esophageal NeoplasmsHras , Kras
Familial Primary Pulmonary HypertensionSmad1
Fatty LiverPrkcd , Shc1
FibrosisSpp1
Focal Cortical Dysplasia of TaylorTsc2
Foreign-Body ReactionSpp1
Gallbladder NeoplasmsKras
Gastrointestinal Stromal TumorsBraf , Kras
Genetic Diseases, InbornMapk1
GerminomaBraf
Giant Pigmented Hairy NevusHras , Nras
GlioblastomaBraf , Dusp6 , Hras , Nras
GliomaBraf , Raf1 , Spp1
GliosisMapk1 , Mapk3
GlomerulonephritisMapk1 , Ptk2b , Smad1 , Spp1
GlomerulosclerosisSpp1
Glomerulosclerosis, Focal SegmentalSpp1
Granulosa Cell TumorSmad1
HamartomaTsc2
Head and Neck NeoplasmsMapk1 , Mapk3
Heart Defects, CongenitalPebp1
Heart DiseasesSpp1
Heart FailurePebp1
Heart Septal Defects, VentricularBraf
Heart Valve DiseasesSpp1
HemangiomaTsc2
HemangiosarcomaHras , Kras
HepatitisSpp1
Hepatitis C, ChronicSpp1
Hepatitis, AcuteTsc2
Hepatitis, ChronicShc1
Hirschsprung DiseaseTsc2
Hirschsprung Disease 1Tsc2
HyperalgesiaDusp6 , Mapk1 , Mapk3 , Raf1
HyperglycemiaShc1
HyperinsulinismPrkcd
HyperlipidemiasShc1
HypersensitivitySpp1
HypertensionKras , Prkcd , Ptk2b
Hypertension, PortalPrkcd
Hypertension, PulmonarySmad1
Hypertension, RenovascularSpp1
Hypertensive NephropathyShc1
HypertrophyMapk1 , Mapk3
Hypertrophy, Left VentricularPrkcd , Ptk2b , Shc1
Hypertrophy, Right VentricularPrkcd
Hypoglossal Nerve InjuriesSmad1
HypogonadismNras , Tsc2
Hypogonadotropic Hypogonadism 19 with or without AnosmiaDusp6
Idiopathic Hypogonadotropic HypogonadismDusp6 , Nras , Tsc2
Infertility, FemaleMapk1 , Mapk3 , Tsc2
Infertility, MaleSmad1
InflammationSpp1 , Tsc2
Insulin ResistancePrkcd , Ptk2b , Shc1
Intellectual DisabilityKras , Rps6ka3 , Tsc2
Intestinal NeoplasmsPrkcd
IschemiaRaf1
Kidney CalculiSpp1
Kidney DiseasesMapk1 , Spp1
Kidney NeoplasmsBraf , Kras , Mapk1 , Mapk3 , Raf1 , Tsc2
Laryngeal NeoplasmsSpp1
LeiomyomaTsc2
LeishmaniasisDusp6
LEOPARD SyndromeBraf , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD syndrome, 2Raf1
LeukemiaNras
Leukemia, ExperimentalNras
Leukemia, Hairy CellMap2k1
Leukemia, Lymphocytic, Chronic, B-CellBraf , Hras , Kras , Nras
Leukemia, Megakaryoblastic, of Down SyndromeNras
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveBraf , Nras
Leukemia, Myeloid, AcuteHras , Kras , Nras , Tsc2
Leukemia, Myelomonocytic, ChronicNras
Leukemia, Myelomonocytic, JuvenileKras , Nras
Leukemia, Promyelocytic, AcuteNras
Leukemia-Lymphoma, Adult T-CellNras
Leukocyte Adhesion Deficiency Type 1Tsc2
LeukocytosisKras , Nras
LeukoencephalopathiesSpp1
liver cancerHras , Kras , Nras
Liver CirrhosisSpp1
Liver Cirrhosis, ExperimentalDusp6 , Prkcd , S1pr1 , Smad1 , Spp1
Liver Diseases, AlcoholicSpp1
Liver Diseases, ParasiticKras
Liver NeoplasmsBraf , Hras , Kras , Nras , Raf1
Liver Neoplasms, ExperimentalHras , Kras , Map2k1 , Mapk1 , Mapk3 , Spp1
lung cancerBraf , Kras
Lung NeoplasmsBraf , Hras , Kras , Mapk1 , Mapk3 , Raf1 , Spp1
LymphangiectasisRaf1
LymphangioleiomyomatosisTsc2
Lymphatic MetastasisPebp1 , Tsc2
LymphomaKras , Nras
Lymphoma, B-CellNras
Lymphoma, Non-HodgkinBraf , Map2k1 , Nras
Lymphoma, T-Cell, CutaneousBraf
MalariaSpp1
Mammary Neoplasms, AnimalDusp6 , Hras , Pebp1 , S1pr1
Mammary Neoplasms, ExperimentalDusp6 , Hras , Pebp1 , S1pr1 , Spp1
Mandibular NeoplasmsBraf
MedulloblastomaNras , Tsc2
MelanomaAraf , Braf , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptk2b , Raf1 , Spp1
Melanoma, Cutaneous Malignant, Susceptibility To, 1Braf , Hras , Map2k1 , Map2k2 , Nras , Raf1
Mental Retardation, X-Linked 19Rps6ka3
MesotheliomaSpp1
Mesothelioma, MalignantRaf1
MicrognathismRps6ka3
Microphthalmia, Syndromic 1Map3k1
Microsatellite InstabilityBraf
Mouth NeoplasmsHras , Kras , Nras , Tsc2
Multiple MyelomaBraf , Hras , Kras , Nras , Spp1
Multiple Organ FailureMapk1
Multiple SclerosisSpp1
Muscular DiseasesPrkcd
Myelodysplastic SyndromesHras , Kras , Nras
Myeloproliferative DisordersKras , Nras
Myocardial InfarctionMapk1 , Pebp1 , Spp1
Myocardial IschemiaDusp6 , Pebp1 , Prkcd
Myocardial Reperfusion InjuryMapk1 , Prkcd , Smad1 , Spp1
MyocarditisSpp1
Myopathy, Congenital, with Excess of Muscle SpindlesHras
Nasopharyngeal CarcinomaKras
Nasopharyngeal NeoplasmsHras , Nras
NeointimaPtk2b
Neoplasm InvasivenessHras , Mapk1 , Mapk3 , Rps6ka3
Neoplasm MetastasisBraf , Kras , Mapk1 , Mapk3 , Pebp1 , Rps6ka3 , Spp1
NeoplasmsBraf , Hras , Kras , Map2k1 , Nras , Spp1
Neoplasms, Cystic, Mucinous, and SerousSpp1
Neoplasms, ExperimentalHras , Kras , Nras , Spp1
Neoplastic ProcessesHras
Neoplastic Syndromes, HereditaryTsc2
Neovascularization, PathologicSpp1
NephritisPtk2b
Nephritis, HereditaryHras
Nephrotic SyndromeSmad1
Nerve DegenerationMapk1 , Mapk3 , Tsc2
Neuritis, Autoimmune, ExperimentalSpp1
NeuroblastomaHras , Kras , Nras , Tsc2
Neurocutaneous MelanosisNras
Neuroendocrine TumorsBraf
NeurofibrosarcomaNras
Neuronopathy, Distal Hereditary Motor, Type VSmad1
Neurotoxicity SyndromesPrkcd
NevusBraf
Nevus, PigmentedNras
Nevus, Sebaceous of JadassohnHras , Kras , Nras
Nonseminomatous Germ Cell TumorBraf
Noonan SyndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1
Noonan syndrome 1Braf , Nras
Noonan syndrome 3Kras
Noonan syndrome 5Raf1
Noonan syndrome 6Nras
Noonan syndrome 7Braf
ObesityPrkcd
Obsessive-Compulsive DisorderHras
Osseous Heteroplasia, ProgressiveSpp1
OsteolysisSpp1
Osteoporosis, PostmenopausalPtk2b
OsteosarcomaTsc2
ovarian cancerKras
Ovarian NeoplasmsBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pebp1 , Spp1
ovarian serous cystadenocarcinomaBraf , Hras , Nras
Pain, PostoperativeDusp6
Pancreatic AdenocarcinomaHras , Kras , Map2k2
pancreatic carcinoma Kras
Pancreatic DiseasesSpp1
Pancreatic NeoplasmsBraf , Kras , Spp1 , Tsc2
PancreatitisDusp6
Pancreatitis, Experimental, Acute Kras
papillary renal cell carcinoma Araf , Braf , Hras
Papillary Renal Cell Carcinoma, SporadicAraf , Braf , Hras
papillary thyroid carcinomaBraf
PapillomaHras
Parkinsonian DisordersPrkcd
Penile NeoplasmsHras , Kras
Phobic DisordersHras
pilocytic astrocytomaKras
Pleomorphic Xanthoastrocytoma Braf
Pleural NeoplasmsSpp1
PneumoniaSpp1
Pneumonia, PneumococcalMapk1 , Mapk3
Polycystic Kidney, Autosomal DominantSpp1
Precancerous ConditionsHras , Pebp1 , Tsc2
Precursor Cell Lymphoblastic Leukemia-LymphomaKras , Nras
Precursor T-Cell Lymphoblastic Leukemia-LymphomaKras
Prostatic Intraepithelial NeoplasiaKras
Prostatic NeoplasmsBraf , Kras , Map2k1 , Mapk3 , Nras , Pebp1 , Ptk2b , Spp1
ProteinuriaSpp1
Psychomotor DisordersRps6ka3
Pulmonary FibrosisSpp1
Pulmonary Valve StenosisHras
Radiation Injuries, ExperimentalMapk1 , Mapk3
RadiculopathySpp1
RASopathiesBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1
Rectal NeoplasmsNras
RecurrenceHras , Kras
Renal FibrosisKras , Mapk1
Renal InsufficiencySpp1
Reperfusion InjuryPtk2b , S1pr1 , Spp1
Sarcoma, ExperimentalKras , Nras
Sarcoma, MyeloidKras
SchizophreniaMapk3
ScrapieSpp1
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
SeizuresDusp6 , Prkcd , Spp1 , Tsc2
SeminomaHras , Kras
SepsisMapk1 , Mapk3
Sezary SyndromeBraf , Mapk1 , Rps6ka1
Shock, HemorrhagicMapk1
Skin NeoplasmsHras , Ptk2b
Smith-Magenis SyndromeKsr1 , Map2k2
Spasms, InfantileTsc2
Spinal Cord InjuriesSpp1
Splenic NeoplasmsHras
SplenomegalyKras , Nras
Spondylocostal Dysostosis 5Mapk3
Squamous Cell Carcinoma of the LungBraf , Hras , Kras
Status EpilepticusPtk2b
Stomach NeoplasmsHras , Kras , Mapk1 , Mapk3 , Nras , Spp1
StrokePrkcd
Substance Withdrawal SyndromeMapk1 , Mapk3
Substance-Related DisordersMknk1
Tachycardia, VentricularRaf1
Testicular Germ Cell TumorHras
Testicular NeoplasmsSmad1
ThymomaHras
Thyroid Cancer, FollicularBraf , Hras , Nras
Thyroid Cancer, MedullaryKras
Thyroid cancer, papillaryBraf
Thyroid NeoplasmsBraf , Hras , Kras , Spp1
Tongue NeoplasmsHras
Trauma, Nervous SystemSpp1
Trichilemmoma Hras
Trigeminal NeuralgiaMapk1 , Mapk3
TuberculosisSpp1
Tuberous SclerosisTsc2
Tuberous Sclerosis 1Tsc2
Tuberous Sclerosis 2Tsc2
Tumor Predisposition SyndromeTsc2
UremiaSpp1
Urethral ObstructionMapk1
Urinary Bladder NeoplasmsHras , Kras , Spp1
Urinary CalculiSpp1
Urinary IncontinenceMapk1
uterine carcinosarcomaHras
Uterine Cervical NeoplasmsHras , Kras , Mapk1 , Nras
Uterine NeoplasmsBraf , Hras , Kras , Map2k1 , Nras
Vascular System InjuriesSpp1
Wounds and InjuriesSpp1
Pathway Annotations Associated with Genes in the the extracellular signal-regulated Raf/Mek/Erk signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
adenosine signaling pathwayBraf , Hras , Map2k2 , Map3k1 , Mapk1 , Rps6ka1
aldosterone signaling pathwayKras , Mapk1 , Mapk3
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
Alzheimer disease pathwayMapk1 , Mapk3
B cell receptor signaling pathwayHras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
bladder cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
Bone morphogenetic proteins signaling pathwayMapk1 , Smad1
brain-derived neurotrophic factor signaling pathwayShc1
c-Jun N-terminal kinases MAPK signaling pathwayMap3k1 , Map3k2 , Spp1
calcium/calcium-mediated signaling pathwayPtk2b
cell-extracellular matrix signaling pathwaySpp1
ceramide signaling pathwayBraf , Kras , Ksr1 , Map2k1 , Map2k2 , Map3k1 , Mapk1 , Mapk3 , Prkcd , Raf1
chemokine mediated signaling pathwayBraf , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Prkcd , Ptk2b , Raf1 , Shc1
chronic myeloid leukemia pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
colorectal cancer pathwayBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
cyclooxygenase mediated pathway of arachidonic acid metabolismMknk1
diabetic nephropathy pathwaySpp1
eicosanoid signaling pathwayPrkcd
endocytosis pathwayHras
endometrial cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
endothelin signaling pathwayHras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Prkcd , Ptk2b , Raf1
ephrin - ephrin receptor bidirectional signaling axisHras , Map2k1 , Mapk1 , Mapk3 , Nras
epidermal growth factor/neuregulin signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
Erk5 MAPK signaling pathwayMap3k2
erythropoietin signaling pathwayHras , Shc1
FasL mediated signaling pathwayMap3k1
Fc epsilon receptor mediated signaling pathwayHras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkcd , Raf1
Fc gamma receptor mediated signaling pathwayMap2k1 , Mapk1 , Mapk3 , Prkcd , Raf1
fibroblast growth factor signaling pathwayMapk1 , Mapk3 , Ptk2b , Rps6ka1 , Shc1 , Spp1
G protein mediated signaling pathway via Galphai familyS1pr1
glioma pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
glutamate signaling pathwayMapk1 , Mapk3
gonadotropin-releasing hormone signaling pathwayHras , Kras , Map2k1 , Map2k2 , Map3k1 , Map3k2 , Mapk1 , Mapk3 , Nras , Prkcd , Ptk2b , Raf1
granulocyte-macrophage colony-stimulating factor signaling pathwayHras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
Hedgehog signaling pathwayMap2k1 , Prkcd
hepatitis C virus infection pathwayBraf , Hras , Kras , Mapk1 , Mapk3 , Nras , Raf1
influenza A virus infection pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3 , Raf1
insulin signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mknk1 , Mknk2 , Nras , Raf1 , Shc1 , Tsc2
insulin-like growth factor signaling pathwayHras , Prkcd , Raf1 , Shc1
interleukin-2 signaling pathwayHras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Ptk2b , Raf1 , Shc1
interleukin-3 signaling pathwayShc1
interleukin-4 signaling pathwayShc1
interleukin-6 signaling pathwayPrkcd
Jak-Stat signaling pathwayPtk2b
kidney disease pathwaySpp1
Leishmania infection pathwayMapk1 , Mapk3
long term depressionBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
long term potentiationBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6
melanoma pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
mitogen activated protein kinase signaling pathwayBraf , Dusp6 , Hras , Kras , Map2k1 , Map2k2 , Map3k1 , Map3k2 , Mapk1 , Mapk3 , Mknk1 , Mknk2 , Nras , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka5 , Rps6ka6 , Shc1 , Tsc2
mTOR signaling pathwayBraf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6 , Tsc2
Mycobacterium tuberculosis infection pathwayMapk1 , Mapk3 , Raf1
neurotrophic factor signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Map3k1 , Mapk1 , Mapk3 , Nras , Prkcd , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka5 , Rps6ka6 , Shc1
NOD-like receptor signaling pathwayMapk1 , Mapk3
non-small cell lung cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
p38 MAPK signaling pathwayMap3k1 , Mknk1 , Mknk2 , Rps6ka4 , Rps6ka5
p53 signaling pathwayPrkcd , Tsc2
pancreatic cancer pathwayBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
phosphatidylinositol 3-kinase class I signaling pathwayHras , Nras
phosphatidylinositol 3-kinase-Akt signaling pathwayRaf1
platelet-derived growth factor signaling pathwayBraf , Hras , Ksr1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkcd , Raf1 , Rps6ka3 , S1pr1 , Shc1
prion diseases pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
protein kinase C (PKC) signaling pathwayPrkcd
renal cell cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMap3k1
Rho/Rac/Cdc42 mediated signaling pathwayPtk2b
scatter factor/hepatocyte growth factor signaling pathwayShc1
sphingosine 1-phosphate signaling pathwayMapk1 , Mapk3 , S1pr1
syndecan signaling pathwayHras , Mapk1 , Mapk3 , Prkcd
T cell receptor signaling pathwayHras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayAraf , Braf , Dusp6 , Hras , Kras , Ksr1 , Map2k1 , Map2k2 , Map3k1 , Map3k2 , Mapk1 , Mapk3 , Mknk1 , Mknk2 , Nras , Pebp1 , Prkcd , Ptk2b , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka4 , Rps6ka5 , Rps6ka6 , S1pr1 , Shc1 , Smad1 , Spp1 , Tsc2
thyroid cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras
Toll-like receptor signaling pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3 , Spp1
Toxoplasma gondii infection pathwayMapk1 , Mapk3
Trail mediated signaling pathwayMap3k1 , Mapk1 , Mapk3
transforming growth factor-beta signaling pathwayTsc2
transforming growth factor-beta Smad dependent signaling pathwayShc1
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Smad1
Trypanosoma cruzi infection pathwayMapk1 , Mapk3
tumor necrosis factor mediated signaling pathwayMap3k1
type 2 diabetes mellitus pathwayMapk1 , Mapk3 , Prkcd
type II interferon signaling pathwayMap2k1 , Map3k1 , Mapk1 , Mapk3 , Prkcd
ubiquitin/proteasome degradation pathwayMap3k1
vascular endothelial growth factor signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkcd , Ptk2b , Raf1
Wnt signaling, canonical pathwayTsc2
Phenotype Annotations Associated with Genes in the the extracellular signal-regulated Raf/Mek/Erk signaling pathway

References Associated with the the extracellular signal-regulated Raf/Mek/Erk signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: