KETONE BODIES METABOLIC PATHWAY (PW:0000069)

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Description

The ketone bodies metabolic pathway is used to convert acetyl-CoA formed in the liver into "ketone bodies": acetone, and more importantly acetoacetate and 3-hydroxybutyrate, which are transported in the blood to extrahepatic tissues where they are converted to acetyl-CoA and oxidized via the citrate cycle pathway for energy. The brain, which usually uses glucose for energy, can utilize ketone bodies under starvation conditions, when glucose is not available. When acetyl-CoA is not being metaboli

Pathway Diagram:

Ariadne Genomics Inc. Adc acetyl- CoA Bdh1 Acat1 Hmgcs2 Oxct1 Oxct2a acetone aceto- acetate 3-hydroxy-3-methyl- glutaryl-CoA ---> acetyl- CoA Aacs 3-hydroxy- butyrate aceto- acetate ---> acetone aceto- acetate ---> 3-hydroxy- butyrate acetyl- CoA ---> 3-hydroxy-3-methyl- glutaryl-CoA aceto- acetate ---> aceto- acetyl-CoA aceto- acetyl-CoA aceto- acetyl-CoA ---> aceto- acetate fatty acid beta degradation pathway ---> acetyl- CoA 3-hydroxy-3-methyl- glutaryl-CoA cholesterol biosynthetic pathway 3-hydroxy-3-methyl- glutaryl-CoA ---> cholesterol biosynthetic pathway 3-hydroxy- butyrate ---> aceto- acetate Bdh2 acetyl- CoA ---> aceto- acetyl-CoA aceto- acetyl-CoA ---> acetyl- CoA aceto- acetyl-CoA ---> 3-hydroxy-3-methyl- glutaryl-CoA Hmgcs1 pyruvate metabolic pathway ---> acetyl- CoA fatty acid biosynthetic pathway fatty acid beta degradation pathway pyruvate metabolic pathway Acat2 3-hydroxy-3-methyl- glutaryl-CoA ---> aceto- acetate acetyl- CoA ---> fatty acid biosynthetic pathway Hmgcl citrate cycle pathway acetyl- CoA ---> citrate cycle pathway
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ketone bodies metabolic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Aacs acetoacetyl-CoA synthetase GBrowse link 12 32,206,863 32,250,583 RGD:2326093
G Acat1 acetyl-CoA acetyltransferase 1 GBrowse link 8 57,044,478 57,072,970 RGD:2326093
RGD:6907045
G Acat2 acetyl-CoA acetyltransferase 2 GBrowse link 1 41,922,020 41,940,074 RGD:2326093
RGD:6907045
G Bdh1 3-hydroxybutyrate dehydrogenase, type 1 GBrowse link 11 71,130,561 71,165,695 RGD:2326093
RGD:6907045
G Bdh2 3-hydroxybutyrate dehydrogenase, type 2 GBrowse link 2 232,765,049 232,785,694 RGD:6907045
G Hmgcl 3-hydroxymethyl-3-methylglutaryl-CoA lyase GBrowse link 5 154,730,232 154,743,974 RGD:2326093
RGD:6907045
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) GBrowse link 2 51,737,090 51,754,583 RGD:6907045
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) GBrowse link 2 193,128,736 193,143,106 RGD:6907045
G Oxct1 3-oxoacid CoA transferase 1 GBrowse link 2 53,189,358 53,217,848 RGD:2326093
RGD:6907045
G Oxct2a 3-oxoacid CoA transferase 2A GBrowse link 5 142,636,815 142,638,554 RGD:6907045
G Oxct2b 3-oxoacid CoA transferase 2B GBrowse link 5 142,432,259 142,434,013 RGD:2326216
ketone bodies biosynthetic pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) GBrowse link 2 51,737,090 51,754,583 RGD:2326134
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) GBrowse link 2 193,128,736 193,143,106 RGD:2326134

Pathway Gene Annotations

Disease Annotations Associated with Genes in the ketone bodies metabolic pathway
Pathway Annotations Associated with Genes in the ketone bodies metabolic pathway

References Associated with the ketone bodies metabolic pathway:

Ontology Path Diagram:

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