FATTY ACID BIOSYNTHETIC PATHWAY (PW:0000029)

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Description

Fatty acids represent an important type of energy storage and are essential components of membranes. Fatty acid synthesis occurs in the cytoplasm and primarily produces the 16-carbon-long, saturated palmitic acid. The starting substrate is acetyl-CoA, the end product of the pyruvate metabolic pathway among others. Formation of acetyl-CoA occurs in the mitochondrion where it condenses with OAA to yield citrate. If energy demands are high, citrate enters the citric acid cycle to complete the full

Pathway Diagram:

Elsevier Inc. acetoacetyl-ACP hydroxyacyl-ACP palmitic acid ---| Acaca palmitoyl-ACP saturated acyl-ACP enoyl-ACP malonyl group sterol regulatory element-binding protein signaling pathway ---> Acly Acly sterol regulatory element-binding protein signaling pathway sterol regulatory element-binding protein signaling pathway ---> Fasn Fasn sterol regulatory element-binding protein signaling pathway ---> Acaca Acaca citrate --+> Acaca malonyl-CoA ADP ATP acetyl group acetyl-CoA oxaloacetate citrate acetyl-CoA ---> malonyl-CoA ATP ---> ADP malonyl-CoA ---> palmitic acid acetyl-CoA ---> palmitic acid saturated acyl-ACP ---> acetoacetyl-ACP citrate ---> oxaloacetate citrate ---> acetyl-CoA palmitic acid
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Genes in Pathway:

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fatty acid biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaca acetyl-CoA carboxylase alpha JBrowse link 10 71,519,392 71,719,910 RGD:2317309
RGD:2317316
RGD:6907045
RGD:10402751
G Acacb acetyl-CoA carboxylase beta JBrowse link 12 48,127,149 48,238,969 RGD:6907045
G Acly ATP citrate lyase JBrowse link 10 88,392,248 88,442,845 RGD:2317309
RGD:2317316
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:2317204
RGD:2317309
RGD:2317317
RGD:6907045
RGD:10402751
G Mcat malonyl-CoA-acyl carrier protein transacylase JBrowse link 7 124,412,762 124,424,966 RGD:6907045
G Olah oleoyl-ACP hydrolase JBrowse link 17 78,878,673 78,903,919 RGD:6907045
G Oxsm 3-oxoacyl-ACP synthase, mitochondrial JBrowse link 15 10,462,380 10,466,496 RGD:6907045
fatty acid elongation pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaa2 acetyl-CoA acyltransferase 2 JBrowse link 18 70,733,872 70,762,395 RGD:6907045
RGD:10402751
G Echs1 enoyl-CoA hydratase, short chain 1 JBrowse link 1 212,570,213 212,579,040 RGD:6907045
RGD:10402751
G Hadh hydroxyacyl-CoA dehydrogenase JBrowse link 2 236,353,445 236,395,067 RGD:6907045
G Hadha hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit JBrowse link 6 27,589,840 27,628,921 RGD:6907045
RGD:10402751
G Hadhb hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit JBrowse link 6 27,555,408 27,589,539 RGD:6907045
RGD:10402751
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 JBrowse link X 21,696,796 21,699,241 RGD:10402751
G Mecr mitochondrial trans-2-enoyl-CoA reductase JBrowse link 5 150,001,281 150,027,407 RGD:6907045
RGD:10402751
G Ppt1 palmitoyl-protein thioesterase 1 JBrowse link 5 140,538,260 140,558,163 RGD:6907045
RGD:10402751
G Ppt2 palmitoyl-protein thioesterase 2 JBrowse link 20 4,381,455 4,401,638 RGD:6907045
unsaturated fatty acid biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaa1a acetyl-CoA acyltransferase 1 JBrowse link 8 128,027,880 128,036,471 RGD:6907045
G Acaa1b acetyl-Coenzyme A acyltransferase 1B JBrowse link 8 127,836,235 127,845,296 RGD:6907045
G Acot1 acyl-CoA thioesterase 1 JBrowse link 6 107,485,088 107,493,082 RGD:6907045
G Acot2 acyl-CoA thioesterase 2 JBrowse link 6 107,460,596 107,468,324 RGD:6907045
G Acot3 acyl-CoA thioesterase 3 JBrowse link 6 107,531,508 107,537,446 RGD:6907045
G Acot4 acyl-CoA thioesterase 4 JBrowse link 6 107,517,668 107,522,952 RGD:6907045
G Acot5 acyl-CoA thioesterase 5 JBrowse link 6 107,550,904 107,557,688 RGD:6907045
G Acot7 acyl-CoA thioesterase 7 JBrowse link 5 169,357,582 169,450,215 RGD:6907045
G Acox1 acyl-CoA oxidase 1 JBrowse link 10 104,724,534 104,748,003 RGD:6907045
G Acox3 acyl-CoA oxidase 3, pristanoyl JBrowse link 14 80,313,202 80,358,115 RGD:6907045
G Baat bile acid CoA:amino acid N-acyltransferase JBrowse link 5 64,768,397 64,777,368 RGD:6907045
G Elovl2 ELOVL fatty acid elongase 2 JBrowse link 17 21,382,461 21,422,413 RGD:6907045
G Elovl5 ELOVL fatty acid elongase 5 JBrowse link 8 85,220,941 85,287,449 RGD:6907045
G Elovl6 ELOVL fatty acid elongase 6 JBrowse link 2 234,187,490 234,296,124 RGD:6907045
G Fads1 fatty acid desaturase 1 JBrowse link 1 226,234,034 226,249,118 RGD:6907045
G Fads2 fatty acid desaturase 2 JBrowse link 1 225,906,582 226,152,568 RGD:6907045
G Hacd1 3-hydroxyacyl-CoA dehydratase 1 JBrowse link 17 81,173,238 81,196,012 RGD:6907045
G Hacd2 3-hydroxyacyl-CoA dehydratase 2 JBrowse link 11 68,893,684 68,985,635 RGD:6907045
G Hadha hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit JBrowse link 6 27,589,840 27,628,921 RGD:6907045
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 JBrowse link 3 82,924,699 83,048,465 RGD:6907045
G Pecr peroxisomal trans-2-enoyl-CoA reductase JBrowse link 9 79,601,937 79,630,547 RGD:6907045
G Scd stearoyl-CoA desaturase JBrowse link 1 264,159,966 264,173,061 RGD:6907045
G Scd2 stearoyl-Coenzyme A desaturase 2 JBrowse link 1 264,059,374 264,072,433 RGD:6907045
G Scd4 stearoyl-coenzyme A desaturase 4 JBrowse link 1 264,094,007 264,105,473 RGD:6907045
G Tecr trans-2,3-enoyl-CoA reductase JBrowse link 19 24,705,478 24,732,024 RGD:6907045

Pathway Gene Annotations

Disease Annotations Associated with Genes in the fatty acid biosynthetic pathway
Pathway Annotations Associated with Genes in the fatty acid biosynthetic pathway

References Associated with the fatty acid biosynthetic pathway:

Ontology Path Diagram:

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