CYTOSOLIC IRON-SULFUR CLUSTER PROTEIN ASSEMBLY PATHWAY (PW:0002636)

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Description

The small inorganic Fe-S cluster (ISC) cofactor acts as an electron carrier in redox and catalytic reactions, and as a sulfur donor and environmental sensor. The ISC proteins can be found in mitochondria, cytoplasm and nucleus and are involved in energy production, tRNA modification and features of protein translation, DNA metabolism and repair. The steps in the assembly of iron-sulfur (Fe-S) clusters (ISC) and delivery to Fe-S proteins are part of the mitochondrial ISC biogenesis and the connec

Pathway Diagram:

Elsevier Inc. Ciao1 Mms19 Fam96b Fam96a nuclear recipients cytosolic recipients mitochondrial iron-sulfur cluster export pathway mitochondrial iron-sulfur cluster protein biogenesis pathway Ndor1 ---> Ciapin1 Ciapin1 ---- Ndor1 Ciapin1 Ndor1 Nubp2 Nubp1 CIA targeting complex Narfl Nubp1 ---- Nubp2 Nubp1 ---> cytosolic recipients Nubp2 ---> nuclear recipients
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Genes in Pathway:

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cytosolic iron-sulfur cluster protein assembly pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ciao1 cytosolic iron-sulfur assembly component 1 JBrowse link 3 119,671,778 119,677,324 RGD:11554190
RGD:11554192
G Ciapin1 cytokine induced apoptosis inhibitor 1 JBrowse link 19 10,596,923 10,612,414 RGD:11554190
RGD:11554192
G Fam96a family with sequence similarity 96, member A JBrowse link 8 71,786,336 71,798,258 RGD:11554190
RGD:11554192
G Fam96b family with sequence similarity 96, member B JBrowse link 19 551,708 553,573 RGD:11554190
RGD:11554192
G Mms19 MMS19 homolog, cytosolic iron-sulfur assembly component JBrowse link 1 261,191,646 261,229,070 RGD:11554190
RGD:11554192
G Narfl nuclear prelamin A recognition factor-like JBrowse link 10 15,143,732 15,152,706 RGD:11554190
RGD:11554192
G Ndor1 NADPH dependent diflavin oxidoreductase 1 JBrowse link 3 2,466,698 2,474,928 RGD:11554190
RGD:11554192
G Nubp1 nucleotide binding protein 1 JBrowse link 10 5,333,378 5,343,949 RGD:11554190
RGD:11554192
G Nubp2 nucleotide binding protein 2 JBrowse link 10 14,244,201 14,247,930 RGD:11554190
RGD:11554192

Pathway Gene Annotations

Disease Annotations Associated with Genes in the cytosolic iron-sulfur cluster protein assembly pathway
Pathway Annotations Associated with Genes in the cytosolic iron-sulfur cluster protein assembly pathway

References Associated with the cytosolic iron-sulfur cluster protein assembly pathway:

Ontology Path Diagram:

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