NICOTINAMIDE ADENINE NUCLEOTIDE UTILIZATION PATHWAY (PW:0002581)

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Description

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme of enzyme-catalyzed reduction-oxidation (redox) reactions. Its discovery and mechanistic understanding span more than a century and brought four Nobel prizes. NAD+ and its reduced form NADH, and the phosphorylated NADP/NADPH forms, serve as hydride acceptors or donors in over 2,000 redox reactions. In addition to its known role as a cofactor in redox reactions, NAD+ serves as a substrate for several classes of enzymes that include

Pathway Diagram:

Elsevier Inc. nicotinamide adenine dinucleotide biosynthetic pathway cyclic ADP-ribose Bst1 Cd38 NAD+ ---> target ribosylation MAR/PAR erasers MAR/PAR readers NAD+ ---> target deacetylation sirtuins ADP-ribosylation pathway, cyclic ribosylation ADP-ribosylation pathway, mono and poly-ribosylation sirtuin mediated pathway MAR/PAR writers (PARPs) NAD+ ---> cyclic ADP-ribose nicotinamide adenine dinucleotide biosynthetic pathway ---> NAD+ target deribosylation NAD+ target ribosylation ---> target deribosylation target ribosylation MAR/PAR readers ---- target ribosylation target deacetylation
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Genes in Pathway:

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ADP-ribosylation pathway, cyclic ribosylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bst1 bone marrow stromal cell antigen 1 JBrowse link 14 71,798,218 71,814,540 RGD:11250406
G Cd38 CD38 molecule JBrowse link 14 71,714,768 71,754,990 RGD:11250406
ADP-ribosylation pathway, mono and poly-ribosylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aplf aprataxin and PNKP like factor JBrowse link 4 119,514,822 119,568,764 RGD:11100038
G Chfr checkpoint with forkhead and ring finger domains JBrowse link 12 52,562,594 52,596,162 RGD:11100038
G Macrod1 MACRO domain containing 1 JBrowse link 1 222,310,916 222,451,485 RGD:11100038
G Macrod2 MACRO domain containing 2 JBrowse link 3 135,729,839 136,422,082 RGD:11100038
G Oard1 O-acyl-ADP-ribose deacylase 1 JBrowse link 9 14,542,957 14,551,519 RGD:11100038
G Parg poly (ADP-ribose) glycohydrolase JBrowse link 16 8,350,168 8,457,999 RGD:11100038
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:11100038
G Parp10 poly (ADP-ribose) polymerase family, member 10 JBrowse link 7 117,291,592 117,300,878 RGD:11100038
G Parp11 poly (ADP-ribose) polymerase family, member 11 JBrowse link 4 160,013,968 160,059,981 RGD:11100038
G Parp12 poly (ADP-ribose) polymerase family, member 12 JBrowse link 4 66,835,647 66,900,324 RGD:11100038
G Parp14 poly (ADP-ribose) polymerase family, member 14 JBrowse link 11 68,105,442 68,137,509 RGD:11100038
G Parp16 poly (ADP-ribose) polymerase family, member 16 JBrowse link 8 70,712,393 70,731,212 RGD:11100038
G Parp2 poly (ADP-ribose) polymerase 2 JBrowse link 15 27,739,416 27,749,650 RGD:11100038
G Parp3 poly (ADP-ribose) polymerase family, member 3 JBrowse link 8 115,173,440 115,179,543 RGD:11100038
G Parp4 poly (ADP-ribose) polymerase family, member 4 JBrowse link 15 36,809,362 36,911,167 RGD:11100038
G Parp6 poly (ADP-ribose) polymerase family, member 6 JBrowse link 8 64,439,933 64,472,443 RGD:11100038
G Parp8 poly (ADP-ribose) polymerase family, member 8 JBrowse link 2 49,086,949 49,455,848 RGD:11100038
G Parp9 poly (ADP-ribose) polymerase family, member 9 JBrowse link 11 67,724,071 67,758,027 RGD:11100038
G Rnf146 ring finger protein 146 JBrowse link 1 30,856,923 30,873,814 RGD:11100038
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase JBrowse link 2 157,316,293 157,342,979 RGD:11100038
G Tnks tankyrase JBrowse link 16 60,925,093 61,067,192 RGD:11100038
G Tnks2 tankyrase 2 RGD:11100038
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 JBrowse link 4 66,012,111 66,062,160 RGD:11100038
Sirtuin mediated pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:11100032
G Sirt2 sirtuin 2 JBrowse link 1 86,948,866 86,971,954 RGD:11100032
G Sirt3 sirtuin 3 JBrowse link 1 213,613,502 213,636,061 RGD:11100032
G Sirt4 sirtuin 4 JBrowse link 12 46,862,358 46,876,593 RGD:11100032
G Sirt5 sirtuin 5 JBrowse link 17 23,986,710 24,013,854 RGD:11100032
G Sirt6 sirtuin 6 JBrowse link 7 10,937,622 10,943,048 RGD:11100032
G Sirt7 sirtuin 7 JBrowse link 10 109,796,046 109,802,821 RGD:11100032

Pathway Gene Annotations

References Associated with the nicotinamide adenine nucleotide utilization pathway:

Ontology Path Diagram:

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