ALTERED MITOCHONDRIAL AUTOPHAGY PATHWAY (PW:0001958)

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Description

Mitochondrial autophagy (mitophagy) is a specialized aspect of the overall, non-selective bulk macroautophagy, or autophagy pathway. Mitophagy allows for the removal of damaged mitochondria and for mitochondrial depletion, as required in certain cell states or in development. Removal of mitochondria proceeds via alternative routes. One involves the Pink1-Parkin duo responding to loss of mitochondrial membrane potential and mediated via ubiquitination events. Another route involves the mitophagy

Pathway Diagram:

Elsevier Inc. Pink1 ---> Parkinson Disease (PD) Park2 ---> Parkinson Disease (PD) Pink1 ---> Parkinson disease pathway Park2 ---> Parkinson disease pathway Parkinson Disease (PD) Park2 Parkinson disease pathway Pink1 Atxn3 translocated cardiolipin other autophagy/mitophagy components Gabarap Map1lc3b Map1lc3a canonical K48, K63 and noncanonical K6, K11 linkages Fundc1 Sqstm1 deubiquitinases Optn Pink1_IMM Map1lc3b ---- translocated cardiolipin casein kinase 2 autophagophore recruitment Pgam5 Bnip3l ---- Map1lc3b Bnip3l ---- Gabarap Src ---| Fundc1 Src ---> Fundc1 Pgam5 ---> Fundc1 Pgam5 --+> Fundc1 Fundc1 ---- Map1lc3b Bnip3 ---- Map1lc3b Fundc1 ---- Map1lc3a Bnip3l ---- Map1lc3a Map1lc3b ---- Optn Map1lc3b ---- Sqstm1 Map1lc3a ---- Optn Map1lc3a ---- Sqstm1 casein kinase 2 ---| Fundc1 casein kinase 2 ---> Fundc1 Src Pink1 ---> Pink1_IMM Parl ---| Pink1_IMM Parl Parl ---> Pink1_IMM Tomm7 Tomm7 --+> Pink1 deubiquitinases ---> Parkin substrates Bnip3 ---- Map1lc3a Atxn3 ---| Park2 Ube2l3 Atxn3 ---- Ube2l3 mitochondria transport pathway mitochondria fusion pathway cardiolipin metabolic pathway Bnip3 hypoxia inducible factor pathway Bnip3l hypoxia inducible factor pathway ---> Bnip3l hypoxia inducible factor pathway ---> Bnip3 Parkin substrates
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Genes in Pathway:

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altered mitochondrial autophagy pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pink1 PTEN induced putative kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:10450527
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:10450527

Pathway Gene Annotations

Disease Annotations Associated with Genes in the altered mitochondrial autophagy pathway
Pathway Annotations Associated with Genes in the altered mitochondrial autophagy pathway
Phenotype Annotations Associated with Genes in the altered mitochondrial autophagy pathway

References Associated with the altered mitochondrial autophagy pathway:

Ontology Path Diagram:

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