METFORMIN PHARMACODYNAMICS PATHWAY (PW:0001490)

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Description

Metformin is an antihyperglycemic drug used in the first-line treatment of Diabetes Mellitus type 2 (T2D). Metformin is the focus of intense current research for its potential role as an anti-cancer agent; reports indicate that cancer risk is reduced in diabetic patients. T2D is associated with an increased risk of cancer, in particular breast, colon, kidney, pancreas and prostate neoplasms and metformin reduces the relative risk of breast, prostate and pancreatic cancers. Metformin is distribut

Pathway Diagram:

Elsevier Inc. Metformin ---| Diabetes Mellitus, Type 2 Metformin ---| type 2 diabetes mellitus pathway type 2 diabetes mellitus pathway Metformin metformin pharmacokinetics pathway ROS respiratory complex I adenosine monophosphate-activated protein kinase (AMPK) signaling pathway Metformin ---| respiratory complex I oxidative phosphorylation pathway Metformin --+> adenosine monophosphate-activated protein kinase (AMPK) signaling pathway Diabetes Mellitus, Type 2
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Additional Elements in Pathway:

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Object TypePathway ObjectPathway Object Description
Complexrespiratory complex Ithe crystal structure of the prokaryotic complex

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