METFORMIN DRUG PATHWAY (PW:0001488)

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Description

Metformin is an antihyperglycemic drug used in the first-line treatment of Diabetes Mellitus type 2 (T2D). Metformin is the focus of intense current research for its potential role as an anti-cancer agent; reports indicate that cancer risk is reduced in diabetic patients. T2D is associated with an increased risk of cancer, in particular breast, colon, kidney, pancreas and prostate neoplasms and metformin reduces the relative risk of breast, prostate and pancreatic cancers. Metformin is distribut

Pathway Diagram:

Elsevier Inc. metformin pharmacodynamics pathway Diabetes Mellitus, Type 2 type 2 diabetes mellitus pathway oxidative phosphorylation pathway adenosine monophosphate-activated protein kinase (AMPK) signaling pathway metformin pharmacokinetics pathway Metformin metformin side effects Nausea Acidosis, Lactic metformin pharmacodynamics pathway ---| Diabetes Mellitus, Type 2 Metformin ---> metformin pharmacokinetics pathway metformin pharmacodynamics pathway --+> Acidosis, Lactic metformin pharmacodynamics pathway --+> Nausea Metformin ---> metformin pharmacodynamics pathway metformin pharmacodynamics pathway --+> GI disturbances GI disturbances metformin pharmacodynamics pathway ---| type 2 diabetes mellitus pathway metformin pharmacodynamics pathway --+> adenosine monophosphate-activated protein kinase (AMPK) signaling pathway metformin pharmacodynamics pathway ---| oxidative phosphorylation pathway
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Genes in Pathway:

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metformin pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc22a1 solute carrier family 22 member 1 JBrowse link 1 48,273,639 48,300,645 RGD:7794727
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:7794727
G Slc22a3 solute carrier family 22 member 3 JBrowse link 1 48,433,079 48,521,261 RGD:7794727
G Slc29a4 solute carrier family 29 member 4 JBrowse link 12 13,914,114 13,924,511 RGD:7794727
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:7794727
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:7794727

Pathway Gene Annotations

References Associated with the metformin drug pathway:

Ontology Path Diagram:

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