LOSARTAN-GENE, GENE-CHEMICAL, GENE-GENE INTERACTION PATHWAY (PW:0001485)

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Description

Losartan is a selective and competitive antagonist of angiotensin II receptor type 1 used in the treatment of hypertension of heart failure. One of several antagonists collectively known as ARBs, losartan is the first marketed and the most frequently prescribed one. In addition to its specific role - see the losartan drug pathway here or from the diagram page, losartan directly or indirectly interacts with a l

Pathway Diagram:

Elsevier Inc. losartan top-Tp53 Tp53 top-Fos top-Srebf1 Srebf1 top-Scarb1 top-Gja1 top-Vcam1 Vcam1 top-Ucp2 Ucp2 Gja1 Fos top-Vegfc Vegfc top-Tgfb1 Tgfb1 top-Faslg Faslg top-Agt top-Edn1 Agt Edn1 the losartan interacting rat genes with SNPs predicted as possibly/probably damaging top-Ccr2 top 10 losartan interacting genes (CTD) all losartan interacting rat genes ---- losartan losartan ---- the losartan interacting rat genes with SNPs predicted as possibly/probably damaging losartan ---- top 10 losartan interacting genes (CTD) Ccr2 Scarb1 losartan ---- the losartan interacting rat genes with nonsynonymous SNPs in sequenced rat strains all losartan interacting rat genes losartan drug pathway the losartan interacting rat genes with nonsynonymous SNPs in sequenced rat strains
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Pathway Gene Annotations

References Associated with the losartan-gene, gene-chemical, gene-gene interaction pathway:

Ontology Path Diagram:

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