LOSARTAN DRUG PATHWAY (PW:0001462)

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Description

Losartan is a selective and competitive non-peptide antagonist of angiotensin II receptor type 1 (Agtr1) used in the treatment of hypertension and heart failure. Angiotensin II (AngII) is one of several and probably the most potent peptide generated by the renin-angiotensin cascade. AngII signals through two receptor types to elicit distinct responses. The Agtr1 mediated pathway is involved in vasoconstriction, proliferation, hormone release and fluid homeostasis. The powerful but potentially h

Pathway Diagram:

Ariadne Genomics Inc. Diabetic Nephropathies urate excretion Stroke angiotensin II signaling pathway via AT1 receptor ---| Hypertension angiotensin II signaling pathway via AT1 receptor ---| Heart Failure losartan pharmacodynamics pathway ---| Stroke losartan pharmacodynamics pathway ---| Diabetic Nephropathies losartan ---> losartan pharmacokinetics pathway losartan ---> losartan pharmacodynamics pathway losartan pharmacodynamics pathway --+> urate excretion losartan pharmacodynamics pathway ---| angiotensin II signaling pathway via AT1 receptor Heart Failure Hypertension angiotensin II signaling pathway via AT1 receptor losartan pharmacokinetics pathway losartan losartan pharmacodynamics pathway losartan pleiotropic effects
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Genes in Pathway:

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losartan pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:10402751
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:10402751
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:7364969
RGD:10402751
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:10402751

Pathway Gene Annotations

References Associated with the losartan drug pathway:

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