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Doxorubucin (DOX, trade name Adriamycin) is an anthracycline derived from Streptomyces bacterium Streptomyces peucetius var. caesius. DOX is used in the treatment of several solid cancers, leukemia and lymphomas. The drug is composed of a planar aromatic ring with an anthraquinone chromophore and a sugar group. Once taken up by the cell and inside the nucleus for which it has a high affinity, the planar ring structure intercalates between adjacent DNA base pairs, preferentia

Pathway Diagram:

Elsevier Inc. doxorubicin response pathway doxorubicin adverse effects, cardiotoxicity intrinsic apoptotic pathway p53 signaling pathway DNA damage ---| Neoplasms DNA damage --+> p53 signaling pathway p53 signaling pathway --+> intrinsic apoptotic pathway doxorubicin pharmacodynamics pathway --+> DNA damage doxorubicin --+> doxorubicin response pathway doxorubicin ---> doxorubicin pharmacodynamics pathway doxorubicin ---> doxorubicin pharmacokinetics pathway damage responses, inhibition of DNA replication, transcription Heart Failure Cardiomyopathies Neoplasms doxorubicin DNA damage doxorubicin pharmacodynamics pathway doxorubicin pharmacokinetics pathway

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doxorubicin pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Top2a topoisomerase (DNA) II alpha JBrowse link 10 86,901,467 86,930,947 RGD:10395260
G Top2b topoisomerase (DNA) II beta JBrowse link 15 10,262,972 10,319,741 RGD:10395260
doxorubicin pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:10395261
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:10402751
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:10395261
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:10395261
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 JBrowse link 4 88,765,441 88,890,268 RGD:10395261
G Akr1a1 aldo-keto reductase family 1 member A1 JBrowse link 5 135,482,068 135,498,693 RGD:10395261
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:10395261
G Cbr1 carbonyl reductase 1 JBrowse link 11 33,813,041 33,815,418 RGD:10395261
G Cbr3 carbonyl reductase 3 JBrowse link 11 33,909,417 33,917,674 RGD:10395261
G Ndufs2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 JBrowse link 13 89,606,848 89,623,506 RGD:10402751
G Ndufs3 NADH dehydrogenase (ubiquinone) Fe-S protein 3 JBrowse link 3 79,721,686 79,728,863 RGD:10402751
G Ndufs7 NADH dehydrogenase (ubiquinone) Fe-S protein 7 JBrowse link 7 12,318,776 12,326,403 RGD:10402751
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:10395262
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:10395262
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:10402751
G Ralbp1 ralA binding protein 1 JBrowse link 9 113,579,107 113,598,477 RGD:10395261
G Slc22a16 solute carrier family 22 member 16 JBrowse link 20 45,658,398 45,669,192 RGD:10395261
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:10395262

Pathway Gene Annotations

References Associated with the doxorubicin drug pathway:

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