AXITINIB DRUG PATHWAY (PW:0001123)

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Description

Axitinib is a selective inhibitor of vascular endothelial growth factor (VEGF) signaling pathway used in the treatment of renal cell carcinoma and several other tumors. The drug belongs to a class of tyrosine kinase receptor inhibitors (TKI) designed to compete with ATP for binding into the ATP binding pocket of the receptor, thus inhibiting its kinase activity and the signaling events downstream of it. Axitinib is selective for VEGF receptor1, 2 and 3; it can also act as a weaker inhibitor for

Pathway Diagram:

Ariadne Genomics Inc. axitinib side effects Fatigue axitinib pharmacokinetics pathway renal cell carcinoma pathway vascular endothelial growth factor signaling pathway axitinib pharmacodynamics pathway Carcinoma, Renal Cell axitinib ---> axitinib pharmacodynamics pathway axitinib ---> axitinib pharmacokinetics pathway vascular endothelial growth factor signaling pathway ---| Carcinoma, Renal Cell axitinib pharmacodynamics pathway ---| vascular endothelial growth factor signaling pathway vascular endothelial growth factor signaling pathway ---| renal cell carcinoma pathway axitinib pharmacodynamics pathway --+> GI disturbances axitinib pharmacodynamics pathway --+> Hypertension axitinib pharmacodynamics pathway --+> Nausea axitinib pharmacodynamics pathway --+> Fatigue Hypertension Nausea GI disturbances axitinib
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Genes in Pathway:

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axitinib pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:6907361
G Flt4 fms-related tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:6907361
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6907361

Pathway Gene Annotations

References Associated with the axitinib drug pathway:

Ontology Path Diagram:

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