ACETYLCHOLINE SIGNALING PATHWAY (PW:0000841)

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Description

Acetylcholine (ACh) is a major neurotransmitter and neuromodulator that plays important roles in the central and peripheral nervous systems, the autonomic nervous system (ANS), and also in non-neuronal cells. In cholinergic neurons acetylcholine is synthetized from acetyl-CoA and choline by the choline O-acetyltransferase Chat. The glucose-derived pyruvate metabolism is the primary source of acetyl-CoA in the brain. Once synthesized, ACh is loaded into synaptic vesicles by the vesicular ACh tran

Pathway Diagram:

Elsevier Inc. ACh ---- nAChR. ACh ---- nAChR immune cells epithelial cells nAChR. acetylcholine signaling via nicotinic acetylcholine receptor --+> parasympathetic postganglion ACh acetylcholine signaling via nicotinic acetylcholine receptor --+> sympathetic postganglion nAChR adrenal medulla sympathetic postganglion norepinephrine ---> terminal structures mAChR ---> decreased heart rate mAChR ---> bronchoconstriction acetylcholine signaling via muscarinic acetylcholine receptor ---> effector tissues acetylcholine acetylcholine signaling via muscarinic acetylcholine receptor acetylcholine signaling via nicotinic acetylcholine receptor norepinephrine epinephrine ACh. acetylcholine signaling via muscarinic acetylcholine receptor ---> forebrain synaptic plasticity emotion learning and/or memory acetylcholine signaling via nicotinic acetylcholine receptor ---> hippocampus brainstem hippocampus forebrain midbrain pallium mAChR effector tissues muscle contraction acetylcholine signaling via nicotinic acetylcholine receptor ---> skeletal muscle fiber decreased heart rate sympathetic preganglion ---> ACh parasympathetic preganglion ---> ACh parasympathetic postganglion ---> ACh. ACh. ---- mAChR sympathetic postganglion ---> norepinephrine epinephrine ---> blood norepinephrine ---> blood adrenal medulla ---> norepinephrine adrenal medulla ---> epinephrine sympathetic preganglion parasympathetic preganglion parasympathetic postganglion acetylcholine signaling via muscarinic acetylcholine receptor ---> epithelial cells acetylcholine signaling via nicotinic acetylcholine receptor ---> epithelial cells blood bronchoconstriction terminal structures skeletal muscle fiber endothelial cells
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Genes in Pathway:

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acetylcholine signaling pathway via muscarinic acetylcholine receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:8549506
G Chat choline O-acetyltransferase JBrowse link 16 8,576,858 8,686,131 RGD:8549504
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:8549590
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:8549592
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:8549594
G Rgs4 regulator of G-protein signaling 4 JBrowse link 13 88,054,817 88,061,108 RGD:8549594
G Rgs6 regulator of G-protein signaling 6 JBrowse link 6 106,310,442 106,598,668 RGD:8549594
G Slc18a3 solute carrier family 18 member A3 JBrowse link 16 8,682,668 8,685,529 RGD:8549504
G Slc5a7 solute carrier family 5 member 7 JBrowse link 9 5,294,377 5,330,822 RGD:8549504
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chrm2 cholinergic receptor, muscarinic 2 JBrowse link 4 64,089,028 64,091,090 RGD:8549585
G Chrm4 cholinergic receptor, muscarinic 4 JBrowse link 3 80,833,272 80,841,165 RGD:8549585
G Gnai1 G protein subunit alpha i1 JBrowse link 4 13,405,136 13,486,866 RGD:8549590
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:8549590
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chrm1 cholinergic receptor, muscarinic 1 JBrowse link 1 224,869,087 224,885,101 RGD:8549585
G Chrm3 cholinergic receptor, muscarinic 3 JBrowse link 17 63,990,599 64,463,222 RGD:8549585
G Chrm5 cholinergic receptor, muscarinic 5 JBrowse link 3 103,966,451 104,018,815 RGD:8549585
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:8549590
G Gna14 G protein subunit alpha 14 JBrowse link 1 235,165,775 235,347,986 RGD:8549590
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:8549590
acetylcholine signaling pathway via nicotinic acetylcholine receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:8549506
G Agrn agrin JBrowse link 5 173,589,910 173,622,813 RGD:8549508
G Chat choline O-acetyltransferase JBrowse link 16 8,576,858 8,686,131 RGD:8549504
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit JBrowse link 3 60,445,657 60,460,724 RGD:8549508
RGD:8549510
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit JBrowse link 1 167,206,722 167,212,199 RGD:8549510
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit JBrowse link 15 42,808,897 42,825,179 RGD:8549510
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit JBrowse link 8 59,594,007 59,607,122 RGD:8549510
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit JBrowse link 3 176,533,182 176,547,965 RGD:8549510
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit JBrowse link 8 59,561,817 59,590,172 RGD:8549510
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit JBrowse link 16 68,860,018 68,866,718 RGD:8549510
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:8549510
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit JBrowse link 14 43,883,450 43,890,171 RGD:8549510
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit JBrowse link 10 56,390,671 56,403,255 RGD:8549508
RGD:8549510
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 2 189,088,570 189,096,785 RGD:8549510
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit JBrowse link 16 68,876,442 68,913,628 RGD:8549510
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit JBrowse link 8 59,610,489 59,629,073 RGD:8549510
G Chrnd cholinergic receptor nicotinic delta subunit JBrowse link 9 94,286,550 94,294,968 RGD:8549508
RGD:8549510
G Chrne cholinergic receptor nicotinic epsilon subunit JBrowse link 10 57,238,960 57,246,750 RGD:8549508
RGD:8549510
G Chrng cholinergic receptor nicotinic gamma subunit JBrowse link 9 94,302,218 94,308,591 RGD:8549508
RGD:8549510
G Dok7 docking protein 7 JBrowse link 14 80,925,409 80,963,454 RGD:8549508
G Lrp4 LDL receptor related protein 4 JBrowse link 3 80,362,643 80,416,684 RGD:8549508
G Musk muscle associated receptor tyrosine kinase JBrowse link 5 75,392,790 75,498,694 RGD:8549508
G Rapsn receptor-associated protein of the synapse JBrowse link 3 79,859,815 79,869,486 RGD:8549508
G Slc18a3 solute carrier family 18 member A3 JBrowse link 16 8,682,668 8,685,529 RGD:8549504
G Slc5a7 solute carrier family 5 member 7 JBrowse link 9 5,294,377 5,330,822 RGD:8549504

Pathway Gene Annotations

References Associated with the acetylcholine signaling pathway:

Ontology Path Diagram:

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