TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY (PW:0000233)
Description
Tumor necrosis factor (Tnf or Tnfa) signaling pathway plays pivotal roles in immunity, cell proliferation, differentiation and apoptosis through the activation of several downstream signaling cascades. Tumor necrosis factor and its receptors Tnfrsf1a and Tnfrsf1b (Tnfr1 and Tnfr2) belong to the tumor necrosis superfamilies of ligands and receptors of which 19 and 29 members have been so far identified in humans, respectively. Tnf signaling occurs primarily via Tnfrsf1a receptor (Tnf-R1), ubiquitously expressed in most tissues. The extracellular domain of Tnf receptors are characterized by the presence of CCGs (
Cysteine-rich domain ) that contribute to the specific ligand-receptor interaction. Tnf, a type II transmembrane protein is processed by Adam17 (known as Tace - Tnf alpha converting enzyme). Binding of soluble, trimeric Tnf to the receptor triggers the trimerization of the receptor and the release of the inhibitory Bag4 protein (known as Sodd) from the receptor intracellular domain. The exposure of the hitherto masked DD (
death domain ) of the receptor allows for interactions with other DD containing proteins. Tradd uses its DD domain to bind to the Tnf-R1 complex where it acts as a scaffold to recruit Traf proteins and Fadd. A Tradd-Traf2 complex shows a 3:3 stoichiometry (
click to see a crystal structure of Tradd-Traf complex ). Recruitment of Traf2 and possibly Traf5, and of Birc2 and 3, known as c-Iap1 and 2, respectively results in a receptor signaling complex that leads to the recruitment and activation of Ripk1 (there is no Traf5 rat gene, human shown). Traf and Birc proteins are E3 ubiquitin ligases involved in the synthesis and attachment of K63-linked polyubiquitin chains; Birc enzymes may also promote K11-linked ubiquitination. Recruitment and ubiquitination of Ripk1 activates this kinase which then activates Map3k7, known as Tak1. Tak1, activated by Tnf signaling and also by interleukin-1 and Toll-like receptors pathways, phosphorylates components of the IKK complex which then activates signaling by Nuclear Factor kappa B (NF-kB). Tak1 is in a complex with Tab adaptor proteins - the interaction with Tab1 possibly promotes the kinase autophosphorylation (
click to see a Tak1-Tab complex ). Tab2 and 3 have ubiquitin binding domains and recruitment of K63-linked ubiquitin chain further activate the kinase (
click to see a Tab2-ubiquitin complex ). The multi-protein Tnf-R1 associated complex also recruits LUBAC - a protein complex with E3 ligase activity that is involved in the synthesis and attachment of linear M1-linked ubiquitin chains. LUBAC ubiquitinates Ripk1 as well as the regulatory subunit of the IKK complex. Deubiquitinases (DUB) such as the A20 editing complex and Cyld revert/modulate this post-translational modification acting as negative regulators of Tnf signaling and of NF-kB, downstream of it. Cyld removes ubiquitin from and/or inhibits ubiquitination of Ripk1. A20 does not have strong DUB activity for K63 ubiquitin but promotes K48-linked ubiquitination of Ripk1 and also inhibits the interaction of E3 ligases Traf and Birc with their E2 partners thus preventing the ubiquitination and activation of Ripk1. K48-ubiquitination of proteins targets them for proteasomal degradation. Tradd can also form a complex with Fadd and procaspase-8; processing of procaspase to its mature Casp8 can trigger the extrinsic apoptotic pathway. However,
in vivo Tnf-mediated apoptosis appears to play a minor role. While Nf-kB is a major pathway activated by Tnf signaling, other pathways such as p38 and c-Jun N terminal kinase (Jnk) MAPK signaling can be activated downstream of Traf2 and Ripk1; Map3k7 is one of the MAPKKKs for the two pathways. Members of Traf and/or Rip families play a role in Nf-KB pathway stimulation downstream of receptors other than Tnfrfs1. Of note is the role of Traf3 which negatively regulates Map3k14 (also known as Nik) - not shown. Upon activation of a subset of tumor receptor superfamily, Traf3 is signal-dependent degraded. This event leads to the activation of Map3k14 and subsequent activation of Ikk alpha component which triggers the non-canonical or alternative NF-kB pathway. Tnf promotes inflammatory responses and deregulation of the pathway has been associated with several autoimmune disorders.
To see the ontology report for annotations, Gviewer and download, click here
[click to see the ontology report for associated GO term
GO:0033209 and entry at Reactome -
REACT_1432.1 ]
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Pathway Diagram:
Genes in Pathway:
G
Adam17
a disintegrin and metallopeptidase domain 17
ISO
PID RGD
PMID:12655295
PID:200102, RGD:2292150
NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633
G
Bag4
BCL2-associated athanogene 4
ISO
PID RGD
PMID:12655295
PID:200102, RGD:2292150
NCBI chr 8:26,254,566...26,275,237
Ensembl chr 8:26,254,566...26,275,315
G
Birc2
baculoviral IAP repeat-containing 2
ISO
PID RGD
PMID:23085193
PID:200102, RGD:7800730
NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065
G
Birc3
baculoviral IAP repeat-containing 3
ISO
PID RGD
PMID:23085193
PID:200102, RGD:7800730
NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187
G
Casp8
caspase 8
ISO
PID
PID:200102
NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
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Cav1
caveolin 1, caveolae protein
ISO
PID
PID:200102
NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451
G
Chuk
conserved helix-loop-helix ubiquitous kinase
ISO
PID RGD
PMID:12655295
PID:200102, RGD:2292150
NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919
G
Cyld
CYLD lysine 63 deubiquitinase
ISO
PID RGD
PMID:23312890 PMID:21119682
PID:200102, RGD:7800734 , RGD:7800735
NCBI chr 8:89,423,506...89,478,574
Ensembl chr 8:89,423,675...89,478,573
G
Fadd
Fas associated via death domain
ISO
PID RGD
PMID:12655295
PID:200102, RGD:2292150
NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200
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Ikbkb
inhibitor of kappaB kinase beta
ISO
PID RGD
PMID:12655295
PID:200102, RGD:2292150
NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
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Ikbkg
inhibitor of kappaB kinase gamma
ISO
PID RGD
PMID:12655295
PID:200102, RGD:2292150
NCBI chr X:73,436,883...73,498,013
Ensembl chr X:73,436,896...73,497,460
G
Itch
itchy, E3 ubiquitin protein ligase
ISO
RGD
PMID:23312890 PMID:21119682
RGD:7800734 , RGD:7800735
NCBI chr 2:154,975,401...155,068,775
Ensembl chr 2:154,975,429...155,068,775
G
Madd
MAP-kinase activating death domain
ISO
PID
PID:200102
NCBI chr 2:90,967,705...91,013,404
Ensembl chr 2:90,967,705...91,014,182
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Map2k3
mitogen-activated protein kinase kinase 3
ISO
PID
PID:200102
NCBI chr11:60,822,880...60,843,637
Ensembl chr11:60,822,859...60,843,637
G
Map2k7
mitogen-activated protein kinase kinase 7
ISO
PID
PID:200102
NCBI chr 8:4,288,740...4,297,897
Ensembl chr 8:4,288,740...4,297,897 Ensembl chr 8:4,288,740...4,297,897
G
Map3k1
mitogen-activated protein kinase kinase kinase 1
ISO
PID
PID:200102
NCBI chr13:111,882,962...111,954,803
Ensembl chr13:111,882,962...111,945,527
G
Map3k3
mitogen-activated protein kinase kinase kinase 3
ISO
PID
PID:200102
NCBI chr11:105,975,358...106,047,482
Ensembl chr11:105,975,439...106,046,272
G
Map3k5
mitogen-activated protein kinase kinase kinase 5
ISO
PID
PID:200102
NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499
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Map3k7
mitogen-activated protein kinase kinase kinase 7
ISO
PID RGD
PMID:21135871
PID:200102, RGD:5490225
NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467
G
Map4k2
mitogen-activated protein kinase kinase kinase kinase 2
ISO
PID
PID:200102
NCBI chr19:6,391,023...6,405,649
Ensembl chr19:6,391,165...6,405,645
G
Map4k3
mitogen-activated protein kinase kinase kinase kinase 3
ISO
PID
PID:200102
NCBI chr17:80,887,942...81,039,118
Ensembl chr17:80,887,941...81,035,914
G
Map4k4
mitogen-activated protein kinase kinase kinase kinase 4
ISO
PID
PID:200102
NCBI chr 1:39,939,806...40,065,470
Ensembl chr 1:39,940,073...40,065,470
G
Map4k5
mitogen-activated protein kinase kinase kinase kinase 5
ISO
PID
PID:200102
NCBI chr12:69,850,531...69,939,937
Ensembl chr12:69,850,524...69,939,974
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Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
ISO
PID
PID:200102
NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
G
Nrk
Nik related kinase
ISO
PID
PID:200102
NCBI chr X:137,814,980...137,911,281
Ensembl chr X:137,815,179...137,911,281
G
Nsmaf
neutral sphingomyelinase (N-SMase) activation associated factor
ISO
PID
PID:200102
NCBI chr 4:6,396,207...6,454,840
Ensembl chr 4:6,396,207...6,454,271
G
Prkci
protein kinase C, iota
ISO
PID
PID:200102
NCBI chr 3:31,049,893...31,106,889
Ensembl chr 3:31,049,896...31,107,108
G
Prkcz
protein kinase C, zeta
ISO
PID
PID:200102
NCBI chr 4:155,344,579...155,445,856
Ensembl chr 4:155,344,586...155,445,818
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Rack1
receptor for activated C kinase 1
ISO
PID
PID:200102
NCBI chr11:48,691,187...48,697,068
Ensembl chr11:48,691,159...48,697,261
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Rbck1
RanBP-type and C3HC4-type zinc finger containing 1
ISO
RGD
PMID:23085193
RGD:7800730
NCBI chr 2:152,158,254...152,174,592
Ensembl chr 2:152,158,254...152,174,573
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Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
ISO
PID
PID:200102
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
G
Rffl
ring finger and FYVE like domain containing protein
ISO
PID
PID:200102
NCBI chr11:82,694,645...82,762,065
Ensembl chr11:82,693,275...82,762,036
G
Ripk1
receptor (TNFRSF)-interacting serine-threonine kinase 1
ISO
PID RGD
PMID:12655295 PMID:23085193
PID:200102, RGD:2292150 , RGD:7800730
NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130
G
Rnf11
ring finger protein 11
ISO
RGD
PMID:23312890 PMID:21119682
RGD:7800734 , RGD:7800735
NCBI chr 4:109,310,054...109,333,702
Ensembl chr 4:109,308,295...109,341,925
G
Rnf31
ring finger protein 31
ISO
RGD
PMID:23085193
RGD:7800730
NCBI chr14:55,829,199...55,841,131
Ensembl chr14:55,829,165...55,841,150
G
Sharpin
SHANK-associated RH domain interacting protein
ISO
RGD
PMID:23085193
RGD:7800730
NCBI chr15:76,231,240...76,235,310
Ensembl chr15:76,231,240...76,235,311
G
Smpd1
sphingomyelin phosphodiesterase 1, acid lysosomal
ISO
PID
PID:200102
NCBI chr 7:105,203,567...105,207,596
Ensembl chr 7:105,203,567...105,207,596
G
Smpd2
sphingomyelin phosphodiesterase 2, neutral
ISO
PID
PID:200102
NCBI chr10:41,363,168...41,366,410
Ensembl chr10:41,361,638...41,366,365
G
Sqstm1
sequestosome 1
ISO
PID
PID:200102
NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
G
Stat1
signal transducer and activator of transcription 1
ISO
PID
PID:200102
NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
G
Tab1
TGF-beta activated kinase 1/MAP3K7 binding protein 1
ISO
RGD
PMID:21135871
RGD:5490225
NCBI chr15:80,017,333...80,045,908
Ensembl chr15:80,017,328...80,045,908
G
Tab2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
ISO
PID RGD
PMID:21135871
PID:200102, RGD:5490225
NCBI chr10:7,781,412...7,832,039
Ensembl chr10:7,781,417...7,831,994
G
Tab3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
ISO
RGD
PMID:21135871
RGD:5490225
NCBI chr X:84,617,466...84,678,075
Ensembl chr X:84,617,628...84,678,075
G
Tax1bp1
Tax1 (human T cell leukemia virus type I) binding protein 1
ISO
RGD
PMID:23312890 PMID:21119682
RGD:7800734 , RGD:7800735
NCBI chr 6:52,690,677...52,743,765
Ensembl chr 6:52,690,714...52,743,765
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Tnf
tumor necrosis factor
ISO
PID RGD
PMID:12655295
PID:200102, RGD:2292150
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
G
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
ISO
PID RGD
PMID:23312890 PMID:21119682
PID:200102, RGD:7800734 , RGD:7800735
NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405
G
Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
ISO
PID RGD
PMID:12655295 PMID:20967881
PID:200102, RGD:2292150 , RGD:5130945
NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
G
Tnfrsf1b
tumor necrosis factor receptor superfamily, member 1b
ISO
PID RGD
PMID:12655295
PID:200102, RGD:2292150
NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440
G
Tnik
TRAF2 and NCK interacting kinase
ISO
PID
PID:200102
NCBI chr 3:28,317,362...28,724,734
Ensembl chr 3:28,317,363...28,730,007
G
Tradd
TNFRSF1A-associated via death domain
ISO
PID RGD
PMID:12655295
PID:200102, RGD:2292150
NCBI chr 8:105,985,207...105,991,226
Ensembl chr 8:105,984,918...105,991,241
G
Traf1
TNF receptor-associated factor 1
ISO
PID
PID:200102
NCBI chr 2:34,831,762...34,851,784
Ensembl chr 2:34,831,762...34,851,784
G
Traf2
TNF receptor-associated factor 2
ISO
PID RGD
PMID:12655295 PMID:20967881 PMID:23085193
PID:200102, RGD:2292150 , RGD:5130945 , RGD:7800730
NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952
G
Traf5
TNF receptor-associated factor 5
ISO
RGD
PMID:23085193
RGD:7800730
NCBI chr 1:191,729,164...191,776,899
Ensembl chr 1:191,729,166...191,776,868
G
Txn1
thioredoxin 1
ISO
PID
PID:200102
NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
Pathway Gene Annotations
Disease Annotations Associated with Genes in the tumor necrosis factor mediated signaling pathway
Adam17 Alzheimer's disease , atopic dermatitis , Blister , Brain Hypoxia , colitis , congestive heart failure , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Colitis , Experimental Liver Cirrhosis , genetic disease , Kidney Reperfusion Injury , Left Ventricular Hypertrophy , Neonatal Inflammatory Skin and Bowel Disease 1 , Pneumococcal Meningitis , renal fibrosis , syndromic microphthalmia 5 , thoracic aortic aneurysm , type 2 diabetes mellitus , ureteral obstruction Bag4 genetic disease , hereditary spastic paraplegia 54 , hypogonadotropic hypogonadism 2 with or without anosmia , pancreatic cancer , paraplegia Birc2 adrenocortical carcinoma , asphyxiating thoracic dystrophy , ataxia telangiectasia , bowenoid papulosis , breast cancer , Breast Neoplasms , cervical cancer , cervical squamous cell carcinoma , colorectal cancer , Disease Progression , gastric adenocarcinoma , genetic disease , head and neck squamous cell carcinoma , human immunodeficiency virus infectious disease , intellectual disability , leukemia , lung non-small cell carcinoma , neuroblastoma , oral squamous cell carcinoma , pancreatic adenocarcinoma , paraganglioma , rectum adenocarcinoma , renal cell carcinoma , skin melanoma , Stomach Neoplasms , Testicular Germ Cell Tumor , thymoma , tongue squamous cell carcinoma Birc3 adrenocortical carcinoma , Alcoholic Fatty Liver , asphyxiating thoracic dystrophy , ataxia telangiectasia , bowenoid papulosis , brain glioma , breast carcinoma , Chronic Hepatitis B , clear cell renal cell carcinoma , Colitis-Associated Neoplasms , colon cancer , colorectal cancer , colorectal carcinoma , Disease Progression , esophagus adenocarcinoma , Experimental Colitis , Experimental Liver Cirrhosis , extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue , gallbladder carcinoma , gastric adenocarcinoma , genetic disease , glioblastoma , head and neck squamous cell carcinoma , Helicobacter Infections , hepatocellular carcinoma , human immunodeficiency virus infectious disease , intellectual disability , leukemia , lung adenocarcinoma , lung non-small cell carcinoma , Mesothelioma , metabolic dysfunction-associated steatohepatitis , neuroblastoma , oral squamous cell carcinoma , ovarian serous cystadenocarcinoma , pancreatic adenocarcinoma , papillary renal cell carcinoma , rectum adenocarcinoma , renal cell carcinoma , steatotic liver disease , Testicular Germ Cell Tumor , thyroid gland carcinoma , urinary bladder cancer Casp8 Acute Liver Failure , Acute Lung Injury , acute lymphoblastic leukemia , adenocarcinoma , Alcohol-Related Disorders , allergic contact dermatitis , Alzheimer's disease , atopic dermatitis , autoimmune disease , autoimmune lymphoproliferative syndrome , autoimmune lymphoproliferative syndrome type 2B , Autoimmune Lymphoproliferative Syndrome, Type V , bacterial infectious disease , Brain Contusion , Brain Hypoxia-Ischemia , Brain Injuries , breast cancer , Breast Cancer, Familial , Breast Neoplasms , bronchopulmonary dysplasia , Cerebral Hemorrhage , Chemical and Drug Induced Liver Injury , chronic obstructive pulmonary disease , Colorectal Neoplasms , common variable immunodeficiency 1 , contact dermatitis , Diabetic Cardiomyopathies , Diabetic Nephropathies , dilated cardiomyopathy , Edema , Esophageal Neoplasms , esophagus adenocarcinoma , esophagus squamous cell carcinoma , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Myocarditis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Experimental Radiation Injuries , Familial Prostate Cancer , genetic disease , head and neck squamous cell carcinoma , heart disease , Hemorrhagic Shock , hepatocellular carcinoma , Huntington's disease , hyperglycemia , hypertension , Insulin Resistance , kidney disease , liver cirrhosis , Liver Reperfusion Injury , lung cancer , Lung Neoplasms , lung non-small cell carcinoma , melanoma , mitochondrial metabolism disease , Myocardial Reperfusion Injury , nephritis , Neurodevelopmental Disorders , Osteoarthritis, Experimental , pancreatic cancer , papillomavirus infectious disease , pre-malignant neoplasm , primary immunodeficiency disease , Primary Pulmonary Hypertension, 1 , Pulmonary Arterial Hypertension , Reperfusion Injury , retinal detachment , sciatic neuropathy , Sepsis , Skin Neoplasms , status epilepticus , Stomach Neoplasms , transient cerebral ischemia , type 1 diabetes mellitus , type 2 diabetes mellitus , Uterine Cervical Neoplasms , Viral Myocarditis Cav1 abdominal aortic aneurysm , acoustic neuroma , Acute Lung Injury , Alcoholic Liver Diseases , Alzheimer's disease , atherosclerosis , atrial fibrillation , brain ischemia , breast cancer , breast carcinoma , Breast Neoplasms , Carcinogenesis , Cardiomegaly , congenital generalized lipodystrophy type 3 , Dermal Fibrosis , diabetes mellitus , Diabetic Nephropathies , diabetic neuropathy , diffuse scleroderma , exfoliation syndrome , Experimental Autoimmune Myocarditis , Experimental Autoimmune Neuritis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , familial partial lipodystrophy , Familial Partial Lipodystrophy Type 7 , genetic disease , Hemorrhage , high grade glioma , Hyperplasia , hypertension , hypertrophic cardiomyopathy , hypothyroidism , invasive ductal carcinoma , leiomyoma , limited scleroderma , low tension glaucoma , Lung Neoplasms , Lymphatic Metastasis , melanoma , multiple sclerosis , Neoplasm Metastasis , Nephrogenic Fibrosing Dermopathy , obesity , open-angle glaucoma , osteoarthritis , ovarian carcinoma , Ovarian Neoplasms , pleomorphic xanthoastrocytoma , primary open angle glaucoma , primary pulmonary hypertension , Primary Pulmonary Hypertension, 3 , prostate cancer , Prostatic Neoplasms , psoriasis , Pulmonary Arterial Hypertension , pulmonary fibrosis , pulmonary hypertension , Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia 2 , renal cell carcinoma , Reperfusion Injury , Sarcopenia , sciatic neuropathy , silicosis , Spinal Cord Injuries , squamous cell carcinoma , Stevens-Johnson syndrome , Stomach Neoplasms , systemic scleroderma , transient cerebral ischemia , transitional cell carcinoma , urinary bladder cancer , Weight Gain Chuk asthma , autistic disorder , bacterial pneumonia , Bartsocas-Papas Syndrome 2 , bone development disease , cleft palate , colitis , colon cancer , Congenital Limb Deformities , Fetal Diseases , fetal encasement syndrome , genetic disease , Inflammation , liver cancer , Multiple Abnormalities , muscular atrophy , Neoplasm Metastasis , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , Skin Abnormalities , skin cancer Cyld Brooke-Spiegler syndrome , Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis-8 , genetic disease , hepatocellular carcinoma , listeriosis , lung non-small cell carcinoma , multiple myeloma , nephronophthisis 14 , ovarian cancer , Skin Neoplasms , thymoma , Trichoepithelioma, Multiple Familial, 2 , Uterine Cervical Neoplasms Fadd abdominal obesity-metabolic syndrome 1 , Acute Lung Injury , acute myeloid leukemia , Aicardi-Goutieres Syndrome 3 , Alzheimer's disease , brain glioma , Brain Hypoxia-Ischemia , Carbon Tetrachloride Poisoning , Chemical and Drug Induced Liver Injury , Chronic Intermittent Hypoxia , Craniofacial Abnormalities , depressive disorder , Diabetic Embryopathy , genetic disease , Hyperoxia , hypertension , intellectual disability , leukemia , Liver Reperfusion Injury , Metabolic Syndrome , middle cerebral artery infarction , morphine dependence , Myocardial Reperfusion Injury , Neoplasm Metastasis , obesity , oculoauricular syndrome , prostatic hypertrophy , Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations , sensorineural hearing loss , Spinal Cord Injuries , Stomatognathic Diseases , transient cerebral ischemia Ikbkb Alzheimer's disease , breast cancer , Choroidal Neovascularization , colitis , colon cancer , dermatitis , Experimental Arthritis , Experimental Diabetes Mellitus , Experimental Melanoma , genetic disease , glucose intolerance , Hirschsprung's disease , Hyperplasia , hypertension , IMMUNODEFICIENCY 15 , immunodeficiency 15A , immunodeficiency 15B , Inflammation , inflammatory bowel disease , Insulin Resistance , Kidney Reperfusion Injury , liver cancer , middle cerebral artery infarction , muscular atrophy , Neonatal Hyperbilirubinemia , obesity , pancreatic ductal adenocarcinoma , Pancreatic Intraepithelial Neoplasia , pancreatitis , pneumonia , prostate adenocarcinoma , prostate cancer , psoriasis , severe combined immunodeficiency , torsion dystonia 6 , transient cerebral ischemia , Transplant Rejection , type 2 diabetes mellitus , vascular disease Ikbkg acute myocardial infarction , adrenoleukodystrophy , autistic disorder , Barth syndrome , Behcet's disease , Bloch-Sulzberger syndrome , cerebral creatine deficiency syndrome 1 , colorectal cancer , common variable immunodeficiency , dyskeratosis congenita , ectodermal dysplasia and immune deficiency , ectodermal dysplasia and immunodeficiency 1 , Emery-Dreifuss muscular dystrophy , Experimental Arthritis , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Pancreatitis , favism , genetic disease , glucosephosphate dehydrogenase deficiency , hepatitis , hepatocellular carcinoma , hypomelanosis of Ito , immunodeficiency 33 , irritable bowel syndrome , learning disability , liver cancer , Liver Reperfusion Injury , Lung Neoplasms , malaria , metabolic dysfunction-associated steatotic liver disease , paraplegia , perinatal necrotizing enterocolitis , periventricular nodular heterotopia , severe congenital encephalopathy due to MECP2 mutation , Splenomegaly , steatotic liver disease , syndromic X-linked intellectual disability Lubs type , Systemic Autoinflammatory Disease, X-Linked Itch genetic disease , long QT syndrome , Multisystem Autoimmune Disease with Facial Dysmorphism Madd congenital disorder of glycosylation type IIc , DEEAH Syndrome , fetal akinesia deformation sequence syndrome 1 , genetic disease , hypertrophic cardiomyopathy , hypertrophic cardiomyopathy 4 , intellectual disability , multiple acyl-CoA dehydrogenase deficiency , NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES, IMPAIRED SPEECH, AND HYPOTONIA , transient cerebral ischemia , type 2 diabetes mellitus Map2k3 breast cancer , cervical cancer , colon cancer , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , genetic disease , glioblastoma , Hyperalgesia , liver benign neoplasm , Lung Neoplasms , malignant astrocytoma , Myocardial Ischemia , Prostatic Neoplasms , restrictive cardiomyopathy , retinal disease , Thyroid Neoplasms Map2k7 breast cancer , Breast Neoplasms , colon adenocarcinoma , colon cancer , congestive heart failure , esophageal carcinoma , Experimental Mammary Neoplasms , familial hemophagocytic lymphohistiocytosis 5 , Fibrosis , genetic disease , larynx cancer , Liver Metastasis , lung adenocarcinoma , lung carcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung squamous cell carcinoma , mucolipidosis type IV , neuroblastoma , Ovarian Neoplasms , pre-malignant neoplasm , prostate cancer , prostate carcinoma in situ , Prostatic Neoplasms , schizophrenia , stomach cancer , urinary bladder cancer Map3k1 46,XY sex reversal 6 , breast cancer , Breast Neoplasms , diffuse gastric cancer , disorder of sexual development , esophagus squamous cell carcinoma , genetic disease , Hearing Loss , hepatocellular carcinoma , lung metastasis , lung non-small cell carcinoma , Neurodevelopmental Disorders , Ovarian Neoplasms , Prostatic Neoplasms , rectum cancer , stomach cancer , syndromic microphthalmia 5 Map3k3 Esophageal Neoplasms , genetic disease , verrucous keratotic hemangioma Map3k5 amyotrophic lateral sclerosis , Arterial Injury , Brain Hypoxia-Ischemia , cardiomyopathy , Carotid Artery Injuries , cerebral infarction , Chemical and Drug Induced Liver Injury , Chronic Cerebral Hypoperfusion , cognitive disorder , congestive heart failure , diabetes mellitus , Experimental Arthritis , Experimental Diabetes Mellitus , Familial Behcet-Like Autoinflammatory Syndrome , genetic disease , Huntington's disease , immunodeficiency 27A , Kidney Reperfusion Injury , melanoma , membranous glomerulonephritis , myocardial infarction , Myocardial Reperfusion Injury , Neointima , Parkinson's disease , perinatal necrotizing enterocolitis , Spinal Cord Injuries , Subarachnoid Hemorrhage , transient cerebral ischemia , Ventilator-Induced Lung Injury , Ventricular Remodeling , visual epilepsy Map3k7 arteriosclerosis , benign hypertensive renal disease , brain edema , Brain Hypoxia-Ischemia , Brain Injuries , brain ischemia , Cachexia , Cardiac Fibrosis , Cardiomegaly , chronic kidney disease , chronic obstructive pulmonary disease , congestive heart failure , coronary artery disease , Diabetic Cardiomyopathies , dilated cardiomyopathy , Embryo Loss , extrahepatic cholestasis , Forney Robinson Pascoe Syndrome , frontometaphyseal dysplasia , frontometaphyseal dysplasia 2 , genetic disease , hypertrophic cardiomyopathy , Liver Reperfusion Injury , Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal Bones , myocardial infarction , Opsismodysplasia , pancreatic ductal carcinoma , prostate cancer , Prostatic Neoplasms , Pulmonary Arterial Hypertension , Stroke , Subarachnoid Hemorrhage , transient cerebral ischemia Map4k2 Bardet-Biedl syndrome , genetic disease , glycogen storage disease V , Hereditary Neoplastic Syndromes , high grade glioma , intellectual disability , leukocyte adhesion deficiency 3 , multiple endocrine neoplasia type 1 Map4k3 congenital heart disease , genetic disease , high grade glioma , Lynch syndrome , Neurodevelopmental Disorders , Temporomandibular Joint Disorders Map4k4 arteriovenous malformations of the brain , colorectal cancer , genetic disease , hepatitis B , hepatocellular carcinoma , imperforate anus , lung adenocarcinoma , Lung Neoplasms , stomach cancer Map4k5 genetic disease , hereditary sensory neuropathy type 1D , hereditary spastic paraplegia 3A Nfkb1 acute kidney failure , adenocarcinoma , alcoholic hepatitis , atrophic gastritis , beta-mannosidosis , brain ischemia , breast cancer , Cerebral Hemorrhage , Cerebral Toxoplasmosis , Chemical and Drug Induced Liver Injury , Chronic Hepatitis C , Colonic Neoplasms , colorectal cancer , common variable immunodeficiency , common variable immunodeficiency 12 , depressive disorder , end stage renal disease , Entamoebiasis , genetic disease , Heat Stroke , hepatocellular carcinoma , High Myopia , Huntington's disease , Hyperoxaluria , Intestinal Helminthiasis , liver disease , lung cancer , lung non-small cell carcinoma , lymphocytic choriomeningitis , melanoma , metabolic dysfunction-associated steatohepatitis , Neoplasm Metastasis , Neoplastic Cell Transformation , ovarian cyst , pancreatic adenocarcinoma , primary biliary cholangitis , primary ciliary dyskinesia 3 , primary immunodeficiency disease , prion disease , prostate cancer , steatotic liver disease , stomach cancer , transient cerebral ischemia , tropical spastic paraparesis , type 2 diabetes mellitus , Viral Bronchiolitis Nrk autistic disorder , genetic disease , syndromic X-linked intellectual disability Lubs type Nsmaf genetic disease Prkci abdominal obesity-metabolic syndrome , autistic disorder , autosomal dominant dyskeratosis congenita 1 , Experimental Diabetes Mellitus , Fanconi syndrome , genetic disease , invasive ductal carcinoma , obesity , ovarian carcinoma , type 2 diabetes mellitus Prkcz autism spectrum disorder , Cardiomegaly , chromosome 1p36 deletion syndrome , congenital myasthenic syndrome 8 , dilated cardiomyopathy 1LL , Ehlers-Danlos syndrome spondylodysplastic type 2 , genetic disease , Goldberg-Shprintzen syndrome , Hyperalgesia , hyperglycemia , idiopathic generalized epilepsy , immunodeficiency 16 , immunodeficiency 38 , Insulin Resistance , Joubert syndrome 25 , Left Ventricular Hypertrophy , leukemia , Neurodevelopmental Disorders , Peroxisome Biogenesis Disorder, Complementation Group 7 , Prostatic Neoplasms , Shprintzen-Goldberg Craniosynostosis , type 2 diabetes mellitus Rack1 morphine dependence , Mouth Neoplasms , squamous cell carcinoma , transient cerebral ischemia Rbck1 Brown-Vialetto-Van Laere syndrome 1 , Cardiomegaly , genetic disease , glycogen storage disease IV , Neurodevelopmental Disorders , Polyglucosan Body Myopathy 1 with or without Immunodeficiency Rela acute necrotizing pancreatitis , adenocarcinoma , Aicardi-Goutieres Syndrome 3 , alcoholic liver cirrhosis , amphetamine abuse , anaplastic large cell lymphoma , arteriosclerosis , Autoinflammatory Disease, Familial, Behcet-Like-3 , Bardet-Biedl syndrome , Barrett's esophagus , Brain Injuries , brain ischemia , Brain Neoplasms , Breast Neoplasms , Cardiomegaly , Cerebral Hemorrhage , cervix uteri carcinoma in situ , Childhood Schizophrenia , cholestasis , cholesteatoma of middle ear , Chronic Intermittent Hypoxia , chronic obstructive pulmonary disease , colitis , Colonic Neoplasms , Crohn's disease , cryptorchidism , cystitis , diabetic angiopathy , Diabetic Nephropathies , Disease Progression , Drug Eruptions , Drug-Induced Dyskinesia , ductal carcinoma in situ , encephalitis , end stage renal disease , epilepsy , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , Experimental Neoplasms , extrahepatic cholestasis , genetic disease , glycogen storage disease V , Heat Stroke , Hemorrhagic Shock , Hepatic Insufficiency , Hepatomegaly , high grade glioma , hypertension , Insulin Resistance , intellectual disability , Intestinal Reperfusion Injury , laryngeal squamous cell carcinoma , Left Ventricular Hypertrophy , liver cirrhosis , lung non-small cell carcinoma , Lymphatic Metastasis , lymphoma , mastoiditis , Myocardial Reperfusion Injury , Neoplasm Invasiveness , Neoplastic Cell Transformation , neuroblastoma , obesity , obstructive sleep apnea , oral squamous cell carcinoma , otitis media , Ovarian Neoplasms , pancreatic cancer , pancreatic ductal carcinoma , Parkinsonism , Pneumococcal Meningitis , primary biliary cholangitis , prostate adenocarcinoma , prostate carcinoma in situ , prostatic hypertrophy , Prostatic Neoplasms , pulmonary hypertension , Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations , renal cell carcinoma , renovascular hypertension , Reperfusion Injury , Sepsis , severe acute respiratory syndrome , Skin Neoplasms , Spinal Cord Injuries , status epilepticus , steatotic liver disease , Stomach Neoplasms , Subarachnoid Hemorrhage , Transplant Rejection , traumatic brain injury , type 2 diabetes mellitus , ulcerative colitis , ureteral obstruction , urinary bladder cancer , Uterine Cervical Neoplasms , uveitis Rffl genetic disease , hypertension , Neurodevelopmental Disorders Ripk1 Autoinflammation with Episodic Fever and Lymphadenopathy , epilepsy , genetic disease , hereditary breast ovarian cancer syndrome , immunodeficiency 57 , lichen planus , retinitis pigmentosa , squamous cell carcinoma Rnf11 genetic disease Rnf31 Brain-Lung-Thyroid Syndrome , Dwarfism , genetic disease , Immunodeficiency 115 , lysinuric protein intolerance , Polyglucosan Body Myopathy 1 with or without Immunodeficiency , Prostatic Neoplasms , Specific Granule Deficiency Sharpin atopic dermatitis , Brown-Vialetto-Van Laere syndrome 2 , dermatitis , Eosinophilia , epidermolysis bullosa simplex with muscular dystrophy , genetic disease , holoprosencephaly Smpd1 Experimental Diabetes Mellitus , Gaucher's disease , genetic disease , intellectual disability , kidney disease , Neoplasm Invasiveness , neuronal ceroid lipofuscinosis , neuronal ceroid lipofuscinosis 6A , Niemann-Pick disease , Niemann-Pick disease type A , Niemann-Pick disease type B , Niemann-Pick disease type C1 , Niemann-Pick Disease, Intermediate, Protracted Neurovisceral , Wilson disease Smpd2 Charcot-Marie-Tooth disease type 4 , genetic disease Sqstm1 amyotrophic lateral sclerosis , Cerebral Hemorrhage , developmental coordination disorder , distal myopathy with rimmed vacuoles , Ehlers-Danlos syndrome dermatosparaxis type , frontotemporal dementia and/or amyotrophic lateral sclerosis 1 , frontotemporal dementia and/or amyotrophic lateral sclerosis 3 , genetic disease , glaucoma , glucose intolerance , GNE myopathy , hypertension , Insulin Resistance , macular degeneration , neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset , Paget's disease of bone , Paget's disease of bone 2 , Paget's disease of bone 3 , Sotos syndrome , Spinal Cord Injuries , Starvation Stat1 angiomyolipoma , Brain Injuries , breast cancer , breast carcinoma , chronic mucocutaneous candidiasis , colon adenocarcinoma , COVID-19 , Cytomegalovirus Infections , disease by infectious agent , Disease Progression , Dwarfism , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Failure to Thrive , gastric adenocarcinoma , genetic disease , Hearing Loss , hepatitis C , hepatocellular carcinoma , Human Influenza , immunodeficiency 31A , immunodeficiency 31B , immunodeficiency 31C , liver cirrhosis , lupus nephritis , lymphangioleiomyomatosis , lymphocytic choriomeningitis , Mycobacterium Infections , Myocardial Reperfusion Injury , Neoplasm Metastasis , nephroblastoma , Nervous System Trauma , Neurodevelopmental Disorders , Nontuberculous Mycobacterium Infections , pancreatic adenocarcinoma , periodontitis , primary immunodeficiency disease , prostate adenocarcinoma , pulmonary fibrosis , Reoviridae Infections , Reperfusion Injury , rheumatoid arthritis , scrapie , Sepsis , severe acute respiratory syndrome , T-cell acute lymphoblastic leukemia Tab1 adenylosuccinase lyase deficiency , genetic disease , polycystic ovary syndrome Tab2 brain disease , cardiomyopathy , chronic obstructive pulmonary disease , Congenital Heart Defects, Multiple Types , Congenital Heart Defects, Multiple Types, 2 , congenital heart disease , dilated cardiomyopathy , Embryo Loss , genetic disease , latent autoimmune diabetes in adults , lung non-small cell carcinoma , migraine , ovary epithelial cancer , pulmonary fibrosis , rheumatoid arthritis , systemic lupus erythematosus , type 1 diabetes mellitus 5 Tab3 autistic disorder , Duchenne muscular dystrophy , genetic disease , Neurodevelopmental Disorders , ornithine carbamoyltransferase deficiency , rheumatoid arthritis , syndromic X-linked intellectual disability Lubs type , systemic lupus erythematosus , X-linked adrenal hypoplasia congenita Tax1bp1 genetic disease , pleomorphic xanthoastrocytoma Tnf acne , acquired immunodeficiency syndrome , Acute Coronary Syndrome , Acute Experimental Pancreatitis , Acute Hepatitis , acute kidney failure , Acute Liver Failure , Acute Lung Injury , acute myocardial infarction , adenocarcinoma , adult respiratory distress syndrome , Aggressive Fibromatosis , Albuminuria , Alcoholic Fatty Liver , alcoholic hepatitis , alcoholic liver cirrhosis , Alcoholic Liver Diseases , allergic bronchopulmonary aspergillosis , allergic contact dermatitis , allergic disease , Alveolar Bone Loss , Alzheimer's disease , Amebic Liver Abscess , amyloidosis , amyotrophic lateral sclerosis , amyotrophic lateral sclerosis type 1 , anemia , Animal Disease Models , anogenital venereal wart , Anorexia , anterior uveitis , anthracosis , anthrax disease , anti-basement membrane glomerulonephritis , Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis , anxiety disorder , aortic valve stenosis , aplastic anemia , Arsenic Poisoning , asbestosis , aspiration pneumonia , asthma , atherosclerosis , atopic dermatitis , atrial fibrillation , autistic disorder , autoimmune hepatitis , autoimmune thyroiditis , B-Cell Chronic Lymphocytic Leukemia , bacterial pneumonia , Behcet's disease , berylliosis , beta thalassemia , bilirubin metabolic disorder , brain edema , brain infarction , Brain Injuries , brain ischemia , breast adenocarcinoma , breast cancer , Breast Neoplasms , Bronchial Hyperreactivity , bronchiectasis , bronchopulmonary dysplasia , Burns , Cachexia , calcinosis , cardiac arrest , Cardiomegaly , cardiomyopathy , Cardiotoxicity , Cardiovascular Pregnancy Complications , Cardiovirus Infections , Cerebral Hemorrhage , cerebral infarction , cervical cancer , Chemical and Drug Induced Liver Injury , Chemically-Induced Disorders , chlamydia , cholestasis , cholesteatoma of middle ear , chorioamnionitis , Chronic Allograft Dysfunction , Chronic Hepatitis C , Chronic Intermittent Hypoxia , chronic obstructive pulmonary disease , cicatricial pemphigoid , cochlear disease , colitis , Colonic Neoplasms , Colorectal Neoplasms , congenital diaphragmatic hernia , congestive heart failure , Cor pulmonale , corneal ulcer , coronary artery disease , coronary restenosis , Coronavirus infectious disease , Cough , COVID-19 , Coxsackievirus Infections , Crohn's disease , cryoglobulinemia , cutaneous leishmaniasis , cystic fibrosis , cystitis , Cytomegalovirus Infections , cytomegalovirus retinitis , degenerative disc disease , demyelinating disease , dermatitis , dermatitis herpetiformis , dermatomyositis , diabetic angiopathy , Diabetic Cardiomyopathies , Diabetic Nephropathies , diabetic neuropathy , diabetic retinopathy , Diaphragmatic Hernia , dilated cardiomyopathy , dilated cardiomyopathy 1H , disease by infectious agent , Disease Progression , disseminated intravascular coagulation , drug allergy , Drug Eruptions , Drug-Related Side Effects and Adverse Reactions , dry eye syndrome , Eales Disease , Edema , Emphysema , encephalitis , encephalomyelitis , end stage renal disease , endometriosis , endophthalmitis , Endotoxemia , epididymitis , epilepsy , erythema nodosum , Escherichia Coli Infections , esophagitis , essential hypertension , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Neuritis , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Experimental Neoplasms , Experimental Radiation Injuries , extrahepatic cholestasis , extrinsic allergic alveolitis , eye disease , Fanconi anemia , farmer's lung , Fever , Fibrosis , focal segmental glomerulosclerosis , Fungal Lung Diseases , gastric ulcer , gastritis , Gaucher's disease , genetic disease , glaucoma , glomerulonephritis , Graves ophthalmopathy , Graves' disease , Hearing Loss , Hearing Loss, Noise-Induced , Heart Injuries , heart valve disease , Heat Stroke , hemochromatosis , hemolytic-uremic syndrome , Hemorrhagic Shock , hepatic encephalopathy , hepatitis A , hepatitis B , hepatocellular carcinoma , hepatopulmonary syndrome , hepatorenal syndrome , hereditary hemorrhagic telangiectasia , herpes simplex virus keratitis , herpes zoster , hidradenitis suppurativa , high grade glioma , High-Frequency Hearing Loss , HIV Wasting Syndrome , human immunodeficiency virus infectious disease , Human Influenza , Hyperalgesia , hypercalcemia , hyperhomocysteinemia , hyperinsulinism , Hyperoxia , hypertension , hypochromic microcytic anemia , hypoglycemia , Hypotension , Hypothermia , idiopathic pulmonary fibrosis , IgA glomerulonephritis , impotence , inclusion body myopathy with Paget disease of bone and frontotemporal dementia , Inflammation , inflammatory bowel disease , Insulin Resistance , intermediate uveitis , interstitial cystitis , Intervertebral Disc Displacement , Intestinal Reperfusion Injury , intracranial aneurysm , Intracranial Hemorrhages , intrahepatic cholestasis of pregnancy , iron deficiency anemia , Kawasaki disease , keratoconjunctivitis sicca , kidney disease , Kidney Reperfusion Injury , labyrinthitis , leishmaniasis , leprosy , listeriosis , liver cirrhosis , liver disease , Liver Neoplasms , Liver Reperfusion Injury , localized scleroderma , low tension glaucoma , lung disease , Lung Injury , Lung Neoplasms , lung non-small cell carcinoma , Lung Reperfusion Injury , lupus nephritis , lymphopenia , malaria , Manganese Poisoning , megacolon , melanoma , Meningeal Tuberculosis , metabolic dysfunction-associated steatohepatitis , metabolic dysfunction-associated steatotic liver disease , Metabolic Syndrome , mevalonic aciduria , Micronuclei, Chromosome-Defective , middle cerebral artery infarction , Middle East respiratory syndrome , migraine , migraine without aura , mitochondrial myopathy , mixed connective tissue disease , mucocutaneous leishmaniasis , mucopolysaccharidosis VI , multiple myeloma , Multiple Organ Failure , multiple sclerosis , muscular atrophy , muscular dystrophy , Mycobacterium avium complex disease , Mycoplasma pneumoniae pneumonia , myelodysplastic syndrome , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , myocardial stunning , myocarditis , myositis , Nasal Polyps , Nausea , Necrosis , Neoplasm Invasiveness , Neoplasm Metastasis , Nerve Degeneration , nervous system disease , Neuralgia , neuroblastoma , Neurogenic Inflammation , neutropenia , obesity , obstructive sleep apnea , occupational asthma , open-angle glaucoma , oral squamous cell carcinoma , oral submucous fibrosis , Osteolysis , otitis media , Otitis Media with Effusion , ovarian cancer , Oxygen-Induced Retinopathy , Pain , Painful Neuropathy , pancreatic cancer , paracoccidioidomycosis , Parkinson's disease , Parkinsonism , Pediatric Crohn's Disease , Penetrating Wounds , peptic esophagitis , perinatal necrotizing enterocolitis , periodontitis , Peripheral Nerve Injuries , peritonitis , periventricular leukomalacia , Picornaviridae Infections , placenta disease , Plaque, Atherosclerotic , plasmacytoma , Plasmodium falciparum malaria , Pleural Effusion , pleurisy , Pneumococcal Meningitis , Pneumococcal Pneumonia , pneumonia , polymyositis , portal hypertension , Postmenopausal Osteoporosis , Postoperative Cognitive Dysfunction , pre-eclampsia , Pregnancy-Induced Hypertension , Premature Birth , primary biliary cholangitis , Primary Graft Dysfunction , primary open angle glaucoma , primary sclerosing cholangitis , prostate cancer , proteasome-associated autoinflammatory syndrome 1 , Pseudomonas Infections , psoriasis , psoriatic arthritis , pulmonary edema , pulmonary emphysema , pulmonary fibrosis , pulmonary hypertension , pulmonary sarcoidosis , pulmonary tuberculosis , pustulosis of palm and sole , Radiation Pneumonitis , radiculopathy , Refractory Anemia , relapsing polychondritis , renal cell carcinoma , renal hypertension , Reperfusion Injury , respiratory allergy , respiratory syncytial virus infectious disease , respiratory system disease , Respiratory Tract Infections , Retina Reperfusion Injury , retinal artery occlusion , retinal detachment , retinal disease , rheumatoid arthritis , rhinitis , Rhinosinusitis , Right Ventricular Hypertrophy , root resorption , SAPHO syndrome , sarcoma , schizophrenia , sciatic neuropathy , scleritis , sensorineural hearing loss , Sepsis , septic arthritis , severe acute respiratory syndrome , Shock , sickle cell anemia , silicosis , Sjogren's syndrome , skin disease , small cell carcinoma , Soft Tissue Neoplasms , Spinal Cord Compression , Spinal Cord Injuries , Spine Osteoarthritis , spondyloarthropathy , Stable Angina , status epilepticus , steatotic liver disease , Stevens-Johnson syndrome , Stomach Neoplasms , Streptococcal Infections , Streptococcus pneumonia , Stroke , Subarachnoid Hemorrhage , Sudden Hearing Loss , Systemic Candidiasis , systemic lupus erythematosus , Tachycardia , Temporomandibular Joint Disorders , thalassemia , thrombocytopenia , thrombosis , Thyroid Neoplasms , Tinnitus , Tongue Neoplasms , toxic shock syndrome , trachoma , transient cerebral ischemia , transitional cell carcinoma , Transplant Rejection , traumatic brain injury , trichinosis , trigeminal neuralgia , tuberculosis , type 1 diabetes mellitus , type 2 diabetes mellitus , typhoid fever , ulcerative colitis , ureteral obstruction , urinary bladder cancer , urticaria , uveitis , vascular dementia , vascular disease , Vascular System Injuries , Venous Thromboembolism , Ventricular Dysfunction , Viral Bronchiolitis , viral pneumonia , visceral leishmaniasis , visual epilepsy , vitiligo , Vogt-Koyanagi-Harada disease , Vulvar Vestibulitis , Weight Gain , Weill-Marchesani syndrome , Wilson disease , Wounds and Injuries Tnfaip3 autoimmune disease , breast cancer , cholangiocarcinoma , Chronic Hepatitis B , colon cancer , colorectal cancer , COVID-19 , esophageal cancer , esophagus squamous cell carcinoma , Familial Behcet-Like Autoinflammatory Syndrome , familial Behcet-like autoinflammatory syndrome 1 , follicular lymphoma , genetic disease , hepatocellular carcinoma , Hereditary Autoinflammatory Diseases , Inflammation , metabolic dysfunction-associated steatotic liver disease , multiple sclerosis , nasopharynx carcinoma , Neoplastic Cell Transformation , Nontuberculous Mycobacterium Infections , primary cutaneous T-cell non-Hodgkin lymphoma , psoriasis , rheumatoid arthritis , Sjogren's syndrome , stomach carcinoma , systemic lupus erythematosus , ulcerative colitis Tnfrsf1a acne , acquired immunodeficiency syndrome , Acute Experimental Pancreatitis , acute kidney failure , adult respiratory distress syndrome , allergic bronchopulmonary aspergillosis , allergic disease , Alzheimer's disease , amyloidosis , anemia , Anorexia , Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis , arteriosclerosis , asthma , autoimmune disease , autosomal dominant familial periodic fever , autosomal recessive pseudohypoaldosteronism type 1 , bacterial pneumonia , Behcet's disease , Brain Injuries , brain ischemia , bronchiectasis 1 , Cachexia , CHARGE syndrome , Chediak-Higashi syndrome , Chronic Hepatitis C , chronic obstructive pulmonary disease , colon carcinoma , colorectal adenoma , congestive heart failure , coronary artery disease , COVID-19 , Crohn's disease , cryptogenic organizing pneumonia , cystic fibrosis , cytomegalovirus retinitis , Diabetic Nephropathies , Embryo Loss , End Stage Liver Disease , end stage renal disease , endometrial cancer , Enterovirus Infections , Experimental Arthritis , Experimental Autoimmune Uveoretinitis , Experimental Colitis , Experimental Diabetes Mellitus , extrinsic allergic alveolitis , familial mediterranean fever , Febrile Seizures , Fever , fibrosarcoma , focal segmental glomerulosclerosis , genetic disease , glomerulonephritis , Human Influenza , Hyperalgesia , Hyperoxia , Hyperphosphatemic Familial Tumoral Calcinosis 1 , IgA glomerulonephritis , Insulin Resistance , ischemia , kidney disease , Kidney Reperfusion Injury , Legionnaires' disease , Liver Reperfusion Injury , Lung Injury , lung non-small cell carcinoma , lupus nephritis , lymphoproliferative syndrome 2 , Metabolic Syndrome , middle cerebral artery infarction , multiple sclerosis , Muscle Weakness , myocardial infarction , Nasal Polyps , Nematode Infections , Neurogenic Inflammation , obesity , obstructive sleep apnea , Optic Nerve Injuries , ovarian cancer , Pain , peroxisome biogenesis disorder 2B , pneumonia , polymyositis , primary biliary cholangitis , Pseudomonas Infections , psoriasis , Radiation Pneumonitis , renal cell carcinoma , renal fibrosis , Reperfusion Injury , retinal detachment , rheumatoid arthritis , root resorption , sciatic neuropathy , silicosis , Spinal Cord Compression , Spinal Cord Injuries , squamous cell carcinoma , systemic lupus erythematosus , Temtamy syndrome , transient cerebral ischemia , type 2 diabetes mellitus , ureteral obstruction , uveitis , visual epilepsy Tnfrsf1b acne , acquired immunodeficiency syndrome , Acute Experimental Pancreatitis , acute kidney failure , adult respiratory distress syndrome , allergic disease , Alzheimer's disease , ankylosing spondylitis , Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis , autistic disorder , bacterial pneumonia , Bone Fractures , brain ischemia , Bronchial Spasm , cerebral malaria , Charcot-Marie-Tooth disease type 2 , chromosome 1p36 deletion syndrome , chronic obstructive pulmonary disease , colon carcinoma , congestive heart failure , Crohn's disease , cryptogenic organizing pneumonia , Diabetic Nephropathies , end stage renal disease , endometrial cancer , endometriosis , Experimental Arthritis , Experimental Diabetes Mellitus , extrinsic allergic alveolitis , Fatigue , Fetal Death , focal segmental glomerulosclerosis , genetic disease , glomerulonephritis , glomerulosclerosis , Headache , Hyperalgesia , Hypoalbuminemia , IgA glomerulonephritis , Inflammation , Intervertebral Disc Displacement , kidney failure , Legionnaires' disease , liver cirrhosis , lupus nephritis , metabolic dysfunction-associated steatotic liver disease , mycosis fungoides , myocardial infarction , Nasal Polyps , Neurogenic Inflammation , nonprogressive cerebellar ataxia with mental retardation , obesity , osteoporosis , ovarian cancer , Parkinson's disease , Parkinsonism , pneumonia , polymyositis , pre-eclampsia , pulmonary sarcoidosis , renal cell carcinoma , retinal detachment , sciatic neuropathy , Sciatica , Sezary's disease , silicosis , Spinal Cord Compression , Systemic Inflammatory Response Syndrome , systemic lupus erythematosus , Transplant Rejection , tuberculosis , type 2 diabetes mellitus , ureteral obstruction , visual epilepsy Tnik Arsenic Poisoning , autosomal recessive intellectual developmental disorder 54 , colorectal cancer , Fanconi syndrome , genetic disease , hepatocellular carcinoma , juvenile rheumatoid arthritis , lung non-squamous non-small cell carcinoma , pre-malignant neoplasm , skin disease Tradd autosomal dominant dyskeratosis congenita 6 , cataract 5 multiple types , genetic disease , Liver Reperfusion Injury , Optic Nerve Injuries Traf1 genetic disease , multiple sclerosis , patent ductus arteriosus , Prostatic Neoplasms , rheumatoid arthritis , Spontaneous Abortions Traf2 Adams-Oliver Syndrome 5 , autosomal dominant intellectual developmental disorder 8 , autosomal dominant nocturnal frontal lobe epilepsy 5 , developmental and epileptic encephalopathy 14 , epilepsy , genetic disease , Joubert syndrome 1 , Kleefstra syndrome 1 , Leigh disease , primary coenzyme Q10 deficiency 7 , Rafiq syndrome , Transplant Rejection , tuberous sclerosis 1 Traf5 gastrointestinal stromal tumor , genetic disease , parathyroid carcinoma Txn1 Acute Lung Injury , Arterial Occlusive Diseases , Breast Neoplasms , bronchopulmonary dysplasia , cardiomyopathy , Congenital Abnormalities , contact dermatitis , dilated cardiomyopathy , Drug-Related Side Effects and Adverse Reactions , Experimental Diabetes Mellitus , Experimental Neoplasms , fetal akinesia deformation sequence syndrome 1 , genetic disease , glaucoma , hydrocephalus , intermediate coronary syndrome , liver disease , malignant mesothelioma , myocardial infarction , Myocardial Reperfusion Injury , myocarditis , Neoplasm Invasiveness , Neoplasm Metastasis , Reperfusion Injury , steatotic liver disease
46,XY sex reversal 6 Map3k1 abdominal aortic aneurysm Cav1 abdominal obesity-metabolic syndrome Prkci abdominal obesity-metabolic syndrome 1 Fadd acne Tnf , Tnfrsf1a , Tnfrsf1b acoustic neuroma Cav1 acquired immunodeficiency syndrome Tnf , Tnfrsf1a , Tnfrsf1b Acute Coronary Syndrome Tnf Acute Experimental Pancreatitis Tnf , Tnfrsf1a , Tnfrsf1b Acute Hepatitis Tnf acute kidney failure Nfkb1 , Tnf , Tnfrsf1a , Tnfrsf1b Acute Liver Failure Casp8 , Tnf Acute Lung Injury Casp8 , Cav1 , Fadd , Tnf , Txn1 acute lymphoblastic leukemia Casp8 acute myeloid leukemia Fadd acute myocardial infarction Ikbkg , Tnf acute necrotizing pancreatitis Rela Adams-Oliver Syndrome 5 Traf2 adenocarcinoma Casp8 , Nfkb1 , Rela , Tnf adenylosuccinase lyase deficiency Tab1 adrenocortical carcinoma Birc2 , Birc3 adrenoleukodystrophy Ikbkg adult respiratory distress syndrome Tnf , Tnfrsf1a , Tnfrsf1b Aggressive Fibromatosis Tnf Aicardi-Goutieres Syndrome 3 Fadd , Rela Albuminuria Tnf Alcohol-Related Disorders Casp8 Alcoholic Fatty Liver Birc3 , Tnf alcoholic hepatitis Nfkb1 , Tnf alcoholic liver cirrhosis Rela , Tnf Alcoholic Liver Diseases Cav1 , Tnf allergic bronchopulmonary aspergillosis Tnf , Tnfrsf1a allergic contact dermatitis Casp8 , Tnf allergic disease Tnf , Tnfrsf1a , Tnfrsf1b Alveolar Bone Loss Tnf Alzheimer's disease Adam17 , Casp8 , Cav1 , Fadd , Ikbkb , Tnf , Tnfrsf1a , Tnfrsf1b Amebic Liver Abscess Tnf amphetamine abuse Rela amyloidosis Tnf , Tnfrsf1a amyotrophic lateral sclerosis Map3k5 , Sqstm1 , Tnf amyotrophic lateral sclerosis type 1 Tnf anaplastic large cell lymphoma Rela anemia Tnf , Tnfrsf1a angiomyolipoma Stat1 Animal Disease Models Tnf ankylosing spondylitis Tnfrsf1b anogenital venereal wart Tnf Anorexia Tnf , Tnfrsf1a anterior uveitis Tnf anthracosis Tnf anthrax disease Tnf anti-basement membrane glomerulonephritis Tnf Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Tnf , Tnfrsf1a , Tnfrsf1b anxiety disorder Tnf aortic valve stenosis Tnf aplastic anemia Tnf Arsenic Poisoning Tnf , Tnik Arterial Injury Map3k5 Arterial Occlusive Diseases Txn1 arteriosclerosis Map3k7 , Rela , Tnfrsf1a arteriovenous malformations of the brain Map4k4 asbestosis Tnf asphyxiating thoracic dystrophy Birc2 , Birc3 aspiration pneumonia Tnf asthma Chuk , Tnf , Tnfrsf1a ataxia telangiectasia Birc2 , Birc3 atherosclerosis Cav1 , Tnf atopic dermatitis Adam17 , Casp8 , Sharpin , Tnf atrial fibrillation Cav1 , Tnf atrophic gastritis Nfkb1 autism spectrum disorder Prkcz autistic disorder Chuk , Ikbkg , Nrk , Prkci , Tab3 , Tnf , Tnfrsf1b autoimmune disease Casp8 , Tnfaip3 , Tnfrsf1a autoimmune hepatitis Tnf autoimmune lymphoproliferative syndrome Casp8 autoimmune lymphoproliferative syndrome type 2B Casp8 Autoimmune Lymphoproliferative Syndrome, Type V Casp8 autoimmune thyroiditis Tnf Autoinflammation with Episodic Fever and Lymphadenopathy Ripk1 Autoinflammatory Disease, Familial, Behcet-Like-3 Rela autosomal dominant dyskeratosis congenita 1 Prkci autosomal dominant dyskeratosis congenita 6 Tradd autosomal dominant familial periodic fever Tnfrsf1a autosomal dominant intellectual developmental disorder 8 Traf2 autosomal dominant nocturnal frontal lobe epilepsy 5 Traf2 autosomal recessive intellectual developmental disorder 54 Tnik autosomal recessive pseudohypoaldosteronism type 1 Tnfrsf1a B-Cell Chronic Lymphocytic Leukemia Tnf bacterial infectious disease Casp8 bacterial pneumonia Chuk , Tnf , Tnfrsf1a , Tnfrsf1b Bardet-Biedl syndrome Map4k2 , Rela Barrett's esophagus Rela Barth syndrome Ikbkg Bartsocas-Papas Syndrome 2 Chuk Behcet's disease Ikbkg , Tnf , Tnfrsf1a benign hypertensive renal disease Map3k7 berylliosis Tnf beta thalassemia Tnf beta-mannosidosis Nfkb1 bilirubin metabolic disorder Tnf Blister Adam17 Bloch-Sulzberger syndrome Ikbkg bone development disease Chuk Bone Fractures Tnfrsf1b bowenoid papulosis Birc2 , Birc3 Brain Contusion Casp8 brain disease Tab2 brain edema Map3k7 , Tnf brain glioma Birc3 , Fadd Brain Hypoxia Adam17 Brain Hypoxia-Ischemia Casp8 , Fadd , Map3k5 , Map3k7 brain infarction Tnf Brain Injuries Casp8 , Map3k7 , Rela , Stat1 , Tnf , Tnfrsf1a brain ischemia Cav1 , Map3k7 , Nfkb1 , Rela , Tnf , Tnfrsf1a , Tnfrsf1b Brain Neoplasms Rela Brain-Lung-Thyroid Syndrome Rnf31 breast adenocarcinoma Tnf breast cancer Birc2 , Casp8 , Cav1 , Ikbkb , Map2k3 , Map2k7 , Map3k1 , Nfkb1 , Stat1 , Tnf , Tnfaip3 Breast Cancer, Familial Casp8 breast carcinoma Birc3 , Cav1 , Stat1 Breast Neoplasms Birc2 , Casp8 , Cav1 , Map2k7 , Map3k1 , Rela , Tnf , Txn1 Bronchial Hyperreactivity Tnf Bronchial Spasm Tnfrsf1b bronchiectasis Tnf bronchiectasis 1 Tnfrsf1a bronchopulmonary dysplasia Casp8 , Tnf , Txn1 Brooke-Spiegler syndrome Cyld Brown-Vialetto-Van Laere syndrome 1 Rbck1 Brown-Vialetto-Van Laere syndrome 2 Sharpin Burns Tnf Cachexia Map3k7 , Tnf , Tnfrsf1a calcinosis Tnf Carbon Tetrachloride Poisoning Fadd Carcinogenesis Cav1 cardiac arrest Tnf Cardiac Fibrosis Map3k7 Cardiomegaly Cav1 , Map3k7 , Prkcz , Rbck1 , Rela , Tnf cardiomyopathy Map3k5 , Tab2 , Tnf , Txn1 Cardiotoxicity Tnf Cardiovascular Pregnancy Complications Tnf Cardiovirus Infections Tnf Carotid Artery Injuries Map3k5 cataract 5 multiple types Tradd cerebral creatine deficiency syndrome 1 Ikbkg Cerebral Hemorrhage Casp8 , Nfkb1 , Rela , Sqstm1 , Tnf cerebral infarction Map3k5 , Tnf cerebral malaria Tnfrsf1b Cerebral Toxoplasmosis Nfkb1 cervical cancer Birc2 , Map2k3 , Tnf cervical squamous cell carcinoma Birc2 cervix uteri carcinoma in situ Rela Charcot-Marie-Tooth disease type 2 Tnfrsf1b Charcot-Marie-Tooth disease type 4 Smpd2 CHARGE syndrome Tnfrsf1a Chediak-Higashi syndrome Tnfrsf1a Chemical and Drug Induced Liver Injury Casp8 , Fadd , Map3k5 , Nfkb1 , Tnf Chemically-Induced Disorders Tnf Childhood Schizophrenia Rela chlamydia Tnf cholangiocarcinoma Tnfaip3 cholestasis Rela , Tnf cholesteatoma of middle ear Rela , Tnf chorioamnionitis Tnf Choroidal Neovascularization Ikbkb chromosome 1p36 deletion syndrome Prkcz , Tnfrsf1b Chronic Allograft Dysfunction Tnf Chronic Cerebral Hypoperfusion Map3k5 Chronic Hepatitis B Birc3 , Tnfaip3 Chronic Hepatitis C Nfkb1 , Tnf , Tnfrsf1a Chronic Intermittent Hypoxia Fadd , Rela , Tnf chronic kidney disease Map3k7 chronic mucocutaneous candidiasis Stat1 chronic obstructive pulmonary disease Casp8 , Map3k7 , Rela , Tab2 , Tnf , Tnfrsf1a , Tnfrsf1b cicatricial pemphigoid Tnf clear cell renal cell carcinoma Birc3 cleft palate Chuk cochlear disease Tnf cognitive disorder Map3k5 colitis Adam17 , Chuk , Ikbkb , Rela , Tnf Colitis-Associated Neoplasms Birc3 colon adenocarcinoma Map2k7 , Stat1 colon cancer Birc3 , Chuk , Ikbkb , Map2k3 , Map2k7 , Tnfaip3 colon carcinoma Tnfrsf1a , Tnfrsf1b Colonic Neoplasms Nfkb1 , Rela , Tnf colorectal adenoma Tnfrsf1a colorectal cancer Birc2 , Birc3 , Ikbkg , Map4k4 , Nfkb1 , Tnfaip3 , Tnik colorectal carcinoma Birc3 Colorectal Neoplasms Casp8 , Tnf common variable immunodeficiency Ikbkg , Nfkb1 common variable immunodeficiency 1 Casp8 common variable immunodeficiency 12 Nfkb1 Congenital Abnormalities Txn1 congenital diaphragmatic hernia Tnf congenital disorder of glycosylation type IIc Madd congenital generalized lipodystrophy type 3 Cav1 Congenital Heart Defects, Multiple Types Tab2 Congenital Heart Defects, Multiple Types, 2 Tab2 congenital heart disease Map4k3 , Tab2 Congenital Limb Deformities Chuk congenital myasthenic syndrome 8 Prkcz congestive heart failure Adam17 , Map2k7 , Map3k5 , Map3k7 , Tnf , Tnfrsf1a , Tnfrsf1b contact dermatitis Casp8 , Txn1 Cor pulmonale Tnf corneal ulcer Tnf coronary artery disease Map3k7 , Tnf , Tnfrsf1a coronary restenosis Tnf Coronavirus infectious disease Tnf Cough Tnf COVID-19 Stat1 , Tnf , Tnfaip3 , Tnfrsf1a Coxsackievirus Infections Tnf Craniofacial Abnormalities Fadd Crohn's disease Rela , Tnf , Tnfrsf1a , Tnfrsf1b cryoglobulinemia Tnf cryptogenic organizing pneumonia Tnfrsf1a , Tnfrsf1b cryptorchidism Rela cutaneous leishmaniasis Tnf cystic fibrosis Tnf , Tnfrsf1a cystitis Rela , Tnf Cytomegalovirus Infections Stat1 , Tnf cytomegalovirus retinitis Tnf , Tnfrsf1a DEEAH Syndrome Madd degenerative disc disease Tnf demyelinating disease Tnf depressive disorder Fadd , Nfkb1 Dermal Fibrosis Cav1 dermatitis Ikbkb , Sharpin , Tnf dermatitis herpetiformis Tnf dermatomyositis Tnf developmental and epileptic encephalopathy 14 Traf2 developmental coordination disorder Sqstm1 diabetes mellitus Cav1 , Map3k5 diabetic angiopathy Rela , Tnf Diabetic Cardiomyopathies Casp8 , Map3k7 , Tnf Diabetic Embryopathy Fadd Diabetic Nephropathies Casp8 , Cav1 , Rela , Tnf , Tnfrsf1a , Tnfrsf1b diabetic neuropathy Cav1 , Tnf diabetic retinopathy Tnf Diaphragmatic Hernia Tnf diffuse gastric cancer Map3k1 diffuse scleroderma Cav1 dilated cardiomyopathy Casp8 , Map3k7 , Tab2 , Tnf , Txn1 dilated cardiomyopathy 1H Tnf dilated cardiomyopathy 1LL Prkcz disease by infectious agent Stat1 , Tnf Disease Progression Birc2 , Birc3 , Rela , Stat1 , Tnf disorder of sexual development Map3k1 disseminated intravascular coagulation Tnf distal myopathy with rimmed vacuoles Sqstm1 drug allergy Tnf Drug Eruptions Rela , Tnf Drug-Induced Dyskinesia Rela Drug-Related Side Effects and Adverse Reactions Tnf , Txn1 dry eye syndrome Tnf Duchenne muscular dystrophy Tab3 ductal carcinoma in situ Rela Dwarfism Rnf31 , Stat1 dyskeratosis congenita Ikbkg Eales Disease Tnf ectodermal dysplasia and immune deficiency Ikbkg ectodermal dysplasia and immunodeficiency 1 Ikbkg Edema Casp8 , Tnf Ehlers-Danlos syndrome dermatosparaxis type Sqstm1 Ehlers-Danlos syndrome spondylodysplastic type 2 Prkcz Embryo Loss Map3k7 , Tab2 , Tnfrsf1a Emery-Dreifuss muscular dystrophy Ikbkg Emphysema Tnf encephalitis Rela , Tnf encephalomyelitis Tnf End Stage Liver Disease Tnfrsf1a end stage renal disease Nfkb1 , Rela , Tnf , Tnfrsf1a , Tnfrsf1b endometrial cancer Tnfrsf1a , Tnfrsf1b endometriosis Tnf , Tnfrsf1b endophthalmitis Tnf Endotoxemia Tnf Entamoebiasis Nfkb1 Enterovirus Infections Tnfrsf1a Eosinophilia Sharpin epidermolysis bullosa simplex with muscular dystrophy Sharpin epididymitis Tnf epilepsy Rela , Ripk1 , Tnf , Traf2 erythema nodosum Tnf Escherichia Coli Infections Tnf esophageal cancer Tnfaip3 esophageal carcinoma Map2k7 Esophageal Neoplasms Casp8 , Map3k3 esophagitis Tnf esophagus adenocarcinoma Birc3 , Casp8 esophagus squamous cell carcinoma Casp8 , Map3k1 , Tnfaip3 essential hypertension Tnf exfoliation syndrome Cav1 Experimental Arthritis Adam17 , Ikbkb , Ikbkg , Map3k5 , Stat1 , Tnf , Tnfrsf1a , Tnfrsf1b Experimental Autoimmune Encephalomyelitis Adam17 , Casp8 , Stat1 , Tnf Experimental Autoimmune Myocarditis Casp8 , Cav1 Experimental Autoimmune Neuritis Cav1 , Tnf Experimental Autoimmune Uveoretinitis Tnfrsf1a Experimental Colitis Adam17 , Birc3 , Rela , Tnf , Tnfrsf1a Experimental Diabetes Mellitus Casp8 , Cav1 , Ikbkb , Map2k3 , Map3k5 , Prkci , Rela , Smpd1 , Stat1 , Tnf , Tnfrsf1a , Tnfrsf1b , Txn1 Experimental Liver Cirrhosis Adam17 , Birc3 , Cav1 , Ikbkg , Rela , Tnf Experimental Liver Neoplasms Ikbkg , Tnf Experimental Mammary Neoplasms Casp8 , Cav1 , Map2k3 , Map2k7 , Rela , Stat1 , Tnf Experimental Melanoma Ikbkb Experimental Neoplasms Rela , Tnf , Txn1 Experimental Pancreatitis Ikbkg Experimental Radiation Injuries Casp8 , Tnf extrahepatic cholestasis Map3k7 , Rela , Tnf extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue Birc3 extrinsic allergic alveolitis Tnf , Tnfrsf1a , Tnfrsf1b eye disease Tnf Failure to Thrive Stat1 Familial Behcet-Like Autoinflammatory Syndrome Map3k5 , Tnfaip3 familial Behcet-like autoinflammatory syndrome 1 Tnfaip3 familial hemophagocytic lymphohistiocytosis 5 Map2k7 familial mediterranean fever Tnfrsf1a familial partial lipodystrophy Cav1 Familial Partial Lipodystrophy Type 7 Cav1 Familial Prostate Cancer Casp8 Fanconi anemia Tnf Fanconi syndrome Prkci , Tnik farmer's lung Tnf Fatigue Tnfrsf1b favism Ikbkg Febrile Seizures Tnfrsf1a fetal akinesia deformation sequence syndrome 1 Madd , Txn1 Fetal Death Tnfrsf1b Fetal Diseases Chuk fetal encasement syndrome Chuk Fever Tnf , Tnfrsf1a fibrosarcoma Tnfrsf1a Fibrosis Map2k7 , Tnf focal segmental glomerulosclerosis Tnf , Tnfrsf1a , Tnfrsf1b follicular lymphoma Tnfaip3 Forney Robinson Pascoe Syndrome Map3k7 frontometaphyseal dysplasia Map3k7 frontometaphyseal dysplasia 2 Map3k7 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 Sqstm1 frontotemporal dementia and/or amyotrophic lateral sclerosis 3 Sqstm1 Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis-8 Cyld Fungal Lung Diseases Tnf gallbladder carcinoma Birc3 gastric adenocarcinoma Birc2 , Birc3 , Stat1 gastric ulcer Tnf gastritis Tnf gastrointestinal stromal tumor Traf5 Gaucher's disease Smpd1 , Tnf genetic disease Adam17 , Bag4 , Birc2 , Birc3 , Casp8 , Cav1 , Chuk , Cyld , Fadd , Ikbkb , Ikbkg , Itch , Madd , Map2k3 , Map2k7 , Map3k1 , Map3k3 , Map3k5 , Map3k7 , Map4k2 , Map4k3 , Map4k4 , Map4k5 , Nfkb1 , Nrk , Nsmaf , Prkci , Prkcz , Rbck1 , Rela , Rffl , Ripk1 , Rnf11 , Rnf31 , Sharpin , Smpd1 , Smpd2 , Sqstm1 , Stat1 , Tab1 , Tab2 , Tab3 , Tax1bp1 , Tnf , Tnfaip3 , Tnfrsf1a , Tnfrsf1b , Tnik , Tradd , Traf1 , Traf2 , Traf5 , Txn1 glaucoma Sqstm1 , Tnf , Txn1 glioblastoma Birc3 , Map2k3 glomerulonephritis Tnf , Tnfrsf1a , Tnfrsf1b glomerulosclerosis Tnfrsf1b glucose intolerance Ikbkb , Sqstm1 glucosephosphate dehydrogenase deficiency Ikbkg glycogen storage disease IV Rbck1 glycogen storage disease V Map4k2 , Rela GNE myopathy Sqstm1 Goldberg-Shprintzen syndrome Prkcz Graves ophthalmopathy Tnf Graves' disease Tnf head and neck squamous cell carcinoma Birc2 , Birc3 , Casp8 Headache Tnfrsf1b Hearing Loss Map3k1 , Stat1 , Tnf Hearing Loss, Noise-Induced Tnf heart disease Casp8 Heart Injuries Tnf heart valve disease Tnf Heat Stroke Nfkb1 , Rela , Tnf Helicobacter Infections Birc3 hemochromatosis Tnf hemolytic-uremic syndrome Tnf Hemorrhage Cav1 Hemorrhagic Shock Casp8 , Rela , Tnf hepatic encephalopathy Tnf Hepatic Insufficiency Rela hepatitis Ikbkg hepatitis A Tnf hepatitis B Map4k4 , Tnf hepatitis C Stat1 hepatocellular carcinoma Birc3 , Casp8 , Cyld , Ikbkg , Map3k1 , Map4k4 , Nfkb1 , Stat1 , Tnf , Tnfaip3 , Tnik Hepatomegaly Rela hepatopulmonary syndrome Tnf hepatorenal syndrome Tnf Hereditary Autoinflammatory Diseases Tnfaip3 hereditary breast ovarian cancer syndrome Ripk1 hereditary hemorrhagic telangiectasia Tnf Hereditary Neoplastic Syndromes Map4k2 hereditary sensory neuropathy type 1D Map4k5 hereditary spastic paraplegia 3A Map4k5 hereditary spastic paraplegia 54 Bag4 herpes simplex virus keratitis Tnf herpes zoster Tnf hidradenitis suppurativa Tnf high grade glioma Cav1 , Map4k2 , Map4k3 , Rela , Tnf High Myopia Nfkb1 High-Frequency Hearing Loss Tnf Hirschsprung's disease Ikbkb HIV Wasting Syndrome Tnf holoprosencephaly Sharpin human immunodeficiency virus infectious disease Birc2 , Birc3 , Tnf Human Influenza Stat1 , Tnf , Tnfrsf1a Huntington's disease Casp8 , Map3k5 , Nfkb1 hydrocephalus Txn1 Hyperalgesia Map2k3 , Prkcz , Tnf , Tnfrsf1a , Tnfrsf1b hypercalcemia Tnf hyperglycemia Casp8 , Prkcz hyperhomocysteinemia Tnf hyperinsulinism Tnf Hyperoxaluria Nfkb1 Hyperoxia Fadd , Tnf , Tnfrsf1a Hyperphosphatemic Familial Tumoral Calcinosis 1 Tnfrsf1a Hyperplasia Cav1 , Ikbkb hypertension Casp8 , Cav1 , Fadd , Ikbkb , Rela , Rffl , Sqstm1 , Tnf hypertrophic cardiomyopathy Cav1 , Madd , Map3k7 hypertrophic cardiomyopathy 4 Madd Hypoalbuminemia Tnfrsf1b hypochromic microcytic anemia Tnf hypoglycemia Tnf hypogonadotropic hypogonadism 2 with or without anosmia Bag4 hypomelanosis of Ito Ikbkg Hypotension Tnf Hypothermia Tnf hypothyroidism Cav1 idiopathic generalized epilepsy Prkcz idiopathic pulmonary fibrosis Tnf IgA glomerulonephritis Tnf , Tnfrsf1a , Tnfrsf1b Immunodeficiency 115 Rnf31 IMMUNODEFICIENCY 15 Ikbkb immunodeficiency 15A Ikbkb immunodeficiency 15B Ikbkb immunodeficiency 16 Prkcz immunodeficiency 27A Map3k5 immunodeficiency 31A Stat1 immunodeficiency 31B Stat1 immunodeficiency 31C Stat1 immunodeficiency 33 Ikbkg immunodeficiency 38 Prkcz immunodeficiency 57 Ripk1 imperforate anus Map4k4 impotence Tnf inclusion body myopathy with Paget disease of bone and frontotemporal dementia Tnf Inflammation Chuk , Ikbkb , Tnf , Tnfaip3 , Tnfrsf1b inflammatory bowel disease Ikbkb , Tnf Insulin Resistance Casp8 , Ikbkb , Prkcz , Rela , Sqstm1 , Tnf , Tnfrsf1a intellectual disability Birc2 , Birc3 , Fadd , Madd , Map4k2 , Rela , Smpd1 intermediate coronary syndrome Txn1 intermediate uveitis Tnf interstitial cystitis Tnf Intervertebral Disc Displacement Tnf , Tnfrsf1b Intestinal Helminthiasis Nfkb1 Intestinal Reperfusion Injury Rela , Tnf intracranial aneurysm Tnf Intracranial Hemorrhages Tnf intrahepatic cholestasis of pregnancy Tnf invasive ductal carcinoma Cav1 , Prkci iron deficiency anemia Tnf irritable bowel syndrome Ikbkg ischemia Tnfrsf1a Joubert syndrome 1 Traf2 Joubert syndrome 25 Prkcz juvenile rheumatoid arthritis Tnik Kawasaki disease Tnf keratoconjunctivitis sicca Tnf kidney disease Casp8 , Smpd1 , Tnf , Tnfrsf1a kidney failure Tnfrsf1b Kidney Reperfusion Injury Adam17 , Ikbkb , Map3k5 , Tnf , Tnfrsf1a Kleefstra syndrome 1 Traf2 labyrinthitis Tnf laryngeal squamous cell carcinoma Rela larynx cancer Map2k7 latent autoimmune diabetes in adults Tab2 learning disability Ikbkg Left Ventricular Hypertrophy Adam17 , Prkcz , Rela Legionnaires' disease Tnfrsf1a , Tnfrsf1b Leigh disease Traf2 leiomyoma Cav1 leishmaniasis Tnf leprosy Tnf leukemia Birc2 , Birc3 , Fadd , Prkcz leukocyte adhesion deficiency 3 Map4k2 lichen planus Ripk1 limited scleroderma Cav1 listeriosis Cyld , Tnf liver benign neoplasm Map2k3 liver cancer Chuk , Ikbkb , Ikbkg liver cirrhosis Casp8 , Rela , Stat1 , Tnf , Tnfrsf1b liver disease Nfkb1 , Tnf , Txn1 Liver Metastasis Map2k7 Liver Neoplasms Tnf Liver Reperfusion Injury Casp8 , Fadd , Ikbkg , Map3k7 , Tnf , Tnfrsf1a , Tradd localized scleroderma Tnf long QT syndrome Itch low tension glaucoma Cav1 , Tnf lung adenocarcinoma Birc3 , Map2k7 , Map4k4 lung cancer Casp8 , Nfkb1 lung carcinoma Map2k7 lung disease Tnf Lung Injury Tnf , Tnfrsf1a lung metastasis Map3k1 Lung Neoplasms Casp8 , Cav1 , Ikbkg , Map2k3 , Map2k7 , Map4k4 , Tnf lung non-small cell carcinoma Birc2 , Birc3 , Casp8 , Cyld , Map2k7 , Map3k1 , Nfkb1 , Rela , Tab2 , Tnf , Tnfrsf1a lung non-squamous non-small cell carcinoma Tnik Lung Reperfusion Injury Tnf lung squamous cell carcinoma Map2k7 lupus nephritis Stat1 , Tnf , Tnfrsf1a , Tnfrsf1b lymphangioleiomyomatosis Stat1 Lymphatic Metastasis Cav1 , Rela lymphocytic choriomeningitis Nfkb1 , Stat1 lymphoma Rela lymphopenia Tnf lymphoproliferative syndrome 2 Tnfrsf1a Lynch syndrome Map4k3 lysinuric protein intolerance Rnf31 macular degeneration Sqstm1 malaria Ikbkg , Tnf malignant astrocytoma Map2k3 malignant mesothelioma Txn1 Manganese Poisoning Tnf mastoiditis Rela megacolon Tnf melanoma Casp8 , Cav1 , Map3k5 , Nfkb1 , Tnf membranous glomerulonephritis Map3k5 Meningeal Tuberculosis Tnf Mesothelioma Birc3 metabolic dysfunction-associated steatohepatitis Birc3 , Nfkb1 , Tnf metabolic dysfunction-associated steatotic liver disease Ikbkg , Tnf , Tnfaip3 , Tnfrsf1b Metabolic Syndrome Fadd , Tnf , Tnfrsf1a mevalonic aciduria Tnf Micronuclei, Chromosome-Defective Tnf middle cerebral artery infarction Fadd , Ikbkb , Tnf , Tnfrsf1a Middle East respiratory syndrome Tnf migraine Tab2 , Tnf migraine without aura Tnf mitochondrial metabolism disease Casp8 mitochondrial myopathy Tnf Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal Bones Map3k7 mixed connective tissue disease Tnf morphine dependence Fadd , Rack1 Mouth Neoplasms Rack1 mucocutaneous leishmaniasis Tnf mucolipidosis type IV Map2k7 mucopolysaccharidosis VI Tnf Multiple Abnormalities Chuk multiple acyl-CoA dehydrogenase deficiency Madd multiple endocrine neoplasia type 1 Map4k2 multiple myeloma Cyld , Tnf Multiple Organ Failure Tnf multiple sclerosis Cav1 , Tnf , Tnfaip3 , Tnfrsf1a , Traf1 Multisystem Autoimmune Disease with Facial Dysmorphism Itch Muscle Weakness Tnfrsf1a muscular atrophy Chuk , Ikbkb , Tnf muscular dystrophy Tnf Mycobacterium avium complex disease Tnf Mycobacterium Infections Stat1 Mycoplasma pneumoniae pneumonia Tnf mycosis fungoides Tnfrsf1b myelodysplastic syndrome Tnf myocardial infarction Map3k5 , Map3k7 , Tnf , Tnfrsf1a , Tnfrsf1b , Txn1 Myocardial Ischemia Map2k3 , Tnf Myocardial Reperfusion Injury Casp8 , Fadd , Map3k5 , Rela , Stat1 , Tnf , Txn1 myocardial stunning Tnf myocarditis Tnf , Txn1 myositis Tnf Nasal Polyps Tnf , Tnfrsf1a , Tnfrsf1b nasopharynx carcinoma Tnfaip3 Nausea Tnf Necrosis Tnf Nematode Infections Tnfrsf1a Neointima Map3k5 Neonatal Hyperbilirubinemia Ikbkb Neonatal Inflammatory Skin and Bowel Disease 1 Adam17 Neoplasm Invasiveness Rela , Smpd1 , Tnf , Txn1 Neoplasm Metastasis Cav1 , Chuk , Fadd , Nfkb1 , Stat1 , Tnf , Txn1 Neoplastic Cell Transformation Nfkb1 , Rela , Tnfaip3 nephritis Casp8 nephroblastoma Stat1 Nephrogenic Fibrosing Dermopathy Cav1 nephronophthisis 14 Cyld Nerve Degeneration Tnf nervous system disease Tnf Nervous System Trauma Stat1 Neuralgia Tnf neuroblastoma Birc2 , Birc3 , Map2k7 , Rela , Tnf neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset Sqstm1 NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES, IMPAIRED SPEECH, AND HYPOTONIA Madd Neurodevelopmental Disorders Casp8 , Map3k1 , Map4k3 , Prkcz , Rbck1 , Rffl , Stat1 , Tab3 Neurogenic Inflammation Tnf , Tnfrsf1a , Tnfrsf1b neuronal ceroid lipofuscinosis Smpd1 neuronal ceroid lipofuscinosis 6A Smpd1 neutropenia Tnf Niemann-Pick disease Smpd1 Niemann-Pick disease type A Smpd1 Niemann-Pick disease type B Smpd1 Niemann-Pick disease type C1 Smpd1 Niemann-Pick Disease, Intermediate, Protracted Neurovisceral Smpd1 nonprogressive cerebellar ataxia with mental retardation Tnfrsf1b Nontuberculous Mycobacterium Infections Stat1 , Tnfaip3 obesity Cav1 , Fadd , Ikbkb , Prkci , Rela , Tnf , Tnfrsf1a , Tnfrsf1b obstructive sleep apnea Rela , Tnf , Tnfrsf1a occupational asthma Tnf oculoauricular syndrome Fadd open-angle glaucoma Cav1 , Tnf Opsismodysplasia Map3k7 Optic Nerve Injuries Tnfrsf1a , Tradd oral squamous cell carcinoma Birc2 , Birc3 , Rela , Tnf oral submucous fibrosis Tnf ornithine carbamoyltransferase deficiency Tab3 osteoarthritis Cav1 Osteoarthritis, Experimental Casp8 Osteolysis Tnf osteoporosis Tnfrsf1b otitis media Rela , Tnf Otitis Media with Effusion Tnf ovarian cancer Cyld , Tnf , Tnfrsf1a , Tnfrsf1b ovarian carcinoma Cav1 , Prkci ovarian cyst Nfkb1 Ovarian Neoplasms Cav1 , Map2k7 , Map3k1 , Rela ovarian serous cystadenocarcinoma Birc3 ovary epithelial cancer Tab2 Oxygen-Induced Retinopathy Tnf Paget's disease of bone Sqstm1 Paget's disease of bone 2 Sqstm1 Paget's disease of bone 3 Sqstm1 Pain Tnf , Tnfrsf1a Painful Neuropathy Tnf pancreatic adenocarcinoma Birc2 , Birc3 , Nfkb1 , Stat1 pancreatic cancer Bag4 , Casp8 , Rela , Tnf pancreatic ductal adenocarcinoma Ikbkb pancreatic ductal carcinoma Map3k7 , Rela Pancreatic Intraepithelial Neoplasia Ikbkb pancreatitis Ikbkb papillary renal cell carcinoma Birc3 papillomavirus infectious disease Casp8 paracoccidioidomycosis Tnf paraganglioma Birc2 paraplegia Bag4 , Ikbkg parathyroid carcinoma Traf5 Parkinson's disease Map3k5 , Tnf , Tnfrsf1b Parkinsonism Rela , Tnf , Tnfrsf1b patent ductus arteriosus Traf1 Pediatric Crohn's Disease Tnf Penetrating Wounds Tnf peptic esophagitis Tnf perinatal necrotizing enterocolitis Ikbkg , Map3k5 , Tnf periodontitis Stat1 , Tnf Peripheral Nerve Injuries Tnf peritonitis Tnf periventricular leukomalacia Tnf periventricular nodular heterotopia Ikbkg peroxisome biogenesis disorder 2B Tnfrsf1a Peroxisome Biogenesis Disorder, Complementation Group 7 Prkcz Picornaviridae Infections Tnf placenta disease Tnf Plaque, Atherosclerotic Tnf plasmacytoma Tnf Plasmodium falciparum malaria Tnf pleomorphic xanthoastrocytoma Cav1 , Tax1bp1 Pleural Effusion Tnf pleurisy Tnf Pneumococcal Meningitis Adam17 , Rela , Tnf Pneumococcal Pneumonia Tnf pneumonia Ikbkb , Tnf , Tnfrsf1a , Tnfrsf1b polycystic ovary syndrome Tab1 Polyglucosan Body Myopathy 1 with or without Immunodeficiency Rbck1 , Rnf31 polymyositis Tnf , Tnfrsf1a , Tnfrsf1b portal hypertension Tnf Postmenopausal Osteoporosis Tnf Postoperative Cognitive Dysfunction Tnf pre-eclampsia Tnf , Tnfrsf1b pre-malignant neoplasm Casp8 , Map2k7 , Tnik Pregnancy-Induced Hypertension Tnf Premature Birth Tnf primary biliary cholangitis Nfkb1 , Rela , Tnf , Tnfrsf1a primary ciliary dyskinesia 3 Nfkb1 primary coenzyme Q10 deficiency 7 Traf2 primary cutaneous T-cell non-Hodgkin lymphoma Tnfaip3 Primary Graft Dysfunction Tnf primary immunodeficiency disease Casp8 , Nfkb1 , Stat1 primary open angle glaucoma Cav1 , Tnf primary pulmonary hypertension Cav1 Primary Pulmonary Hypertension, 1 Casp8 Primary Pulmonary Hypertension, 3 Cav1 primary sclerosing cholangitis Tnf prion disease Nfkb1 prostate adenocarcinoma Chuk , Ikbkb , Rela , Stat1 prostate cancer Cav1 , Chuk , Ikbkb , Map2k7 , Map3k7 , Nfkb1 , Tnf prostate carcinoma in situ Map2k7 , Rela prostatic hypertrophy Fadd , Rela Prostatic Neoplasms Cav1 , Chuk , Map2k3 , Map2k7 , Map3k1 , Map3k7 , Prkcz , Rela , Rnf31 , Traf1 proteasome-associated autoinflammatory syndrome 1 Tnf Pseudomonas Infections Tnf , Tnfrsf1a psoriasis Cav1 , Ikbkb , Tnf , Tnfaip3 , Tnfrsf1a psoriatic arthritis Tnf Pulmonary Arterial Hypertension Casp8 , Cav1 , Map3k7 pulmonary edema Tnf pulmonary emphysema Tnf pulmonary fibrosis Cav1 , Stat1 , Tab2 , Tnf pulmonary hypertension Cav1 , Rela , Tnf pulmonary sarcoidosis Tnf , Tnfrsf1b pulmonary tuberculosis Tnf pustulosis of palm and sole Tnf Radiation Pneumonitis Tnf , Tnfrsf1a radiculopathy Tnf Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia 2 Cav1 Rafiq syndrome Traf2 rectum adenocarcinoma Birc2 , Birc3 rectum cancer Map3k1 Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations Fadd , Rela Refractory Anemia Tnf relapsing polychondritis Tnf renal cell carcinoma Birc2 , Birc3 , Cav1 , Rela , Tnf , Tnfrsf1a , Tnfrsf1b renal fibrosis Adam17 , Tnfrsf1a renal hypertension Tnf renovascular hypertension Rela Reoviridae Infections Stat1 Reperfusion Injury Casp8 , Cav1 , Rela , Stat1 , Tnf , Tnfrsf1a , Txn1 respiratory allergy Tnf respiratory syncytial virus infectious disease Tnf respiratory system disease Tnf Respiratory Tract Infections Tnf restrictive cardiomyopathy Map2k3 Retina Reperfusion Injury Tnf retinal artery occlusion Tnf retinal detachment Casp8 , Tnf , Tnfrsf1a , Tnfrsf1b retinal disease Map2k3 , Tnf retinitis pigmentosa Ripk1 rheumatoid arthritis Stat1 , Tab2 , Tab3 , Tnf , Tnfaip3 , Tnfrsf1a , Traf1 rhinitis Tnf Rhinosinusitis Tnf Right Ventricular Hypertrophy Tnf root resorption Tnf , Tnfrsf1a SAPHO syndrome Tnf sarcoma Tnf Sarcopenia Cav1 schizophrenia Map2k7 , Tnf sciatic neuropathy Casp8 , Cav1 , Tnf , Tnfrsf1a , Tnfrsf1b Sciatica Tnfrsf1b scleritis Tnf scrapie Stat1 sensorineural hearing loss Fadd , Tnf Sepsis Casp8 , Rela , Stat1 , Tnf septic arthritis Tnf severe acute respiratory syndrome Rela , Stat1 , Tnf severe combined immunodeficiency Ikbkb severe congenital encephalopathy due to MECP2 mutation Ikbkg Sezary's disease Tnfrsf1b Shock Tnf Shprintzen-Goldberg Craniosynostosis Prkcz sickle cell anemia Tnf silicosis Cav1 , Tnf , Tnfrsf1a , Tnfrsf1b Sjogren's syndrome Tnf , Tnfaip3 Skin Abnormalities Chuk skin cancer Chuk skin disease Tnf , Tnik skin melanoma Birc2 Skin Neoplasms Casp8 , Cyld , Rela small cell carcinoma Tnf Soft Tissue Neoplasms Tnf Sotos syndrome Sqstm1 Specific Granule Deficiency Rnf31 Spinal Cord Compression Tnf , Tnfrsf1a , Tnfrsf1b Spinal Cord Injuries Cav1 , Fadd , Map3k5 , Rela , Sqstm1 , Tnf , Tnfrsf1a Spine Osteoarthritis Tnf Splenomegaly Ikbkg spondyloarthropathy Tnf Spontaneous Abortions Traf1 squamous cell carcinoma Cav1 , Rack1 , Ripk1 , Tnfrsf1a Stable Angina Tnf Starvation Sqstm1 status epilepticus Casp8 , Rela , Tnf steatotic liver disease Birc3 , Ikbkg , Nfkb1 , Rela , Tnf , Txn1 Stevens-Johnson syndrome Cav1 , Tnf stomach cancer Map2k7 , Map3k1 , Map4k4 , Nfkb1 stomach carcinoma Tnfaip3 Stomach Neoplasms Birc2 , Casp8 , Cav1 , Rela , Tnf Stomatognathic Diseases Fadd Streptococcal Infections Tnf Streptococcus pneumonia Tnf Stroke Map3k7 , Tnf Subarachnoid Hemorrhage Map3k5 , Map3k7 , Rela , Tnf Sudden Hearing Loss Tnf syndromic microphthalmia 5 Adam17 , Map3k1 syndromic X-linked intellectual disability Lubs type Ikbkg , Nrk , Tab3 Systemic Autoinflammatory Disease, X-Linked Ikbkg Systemic Candidiasis Tnf Systemic Inflammatory Response Syndrome Tnfrsf1b systemic lupus erythematosus Tab2 , Tab3 , Tnf , Tnfaip3 , Tnfrsf1a , Tnfrsf1b systemic scleroderma Cav1 T-cell acute lymphoblastic leukemia Stat1 Tachycardia Tnf Temporomandibular Joint Disorders Map4k3 , Tnf Temtamy syndrome Tnfrsf1a Testicular Germ Cell Tumor Birc2 , Birc3 thalassemia Tnf thoracic aortic aneurysm Adam17 thrombocytopenia Tnf thrombosis Tnf thymoma Birc2 , Cyld thyroid gland carcinoma Birc3 Thyroid Neoplasms Map2k3 , Tnf Tinnitus Tnf Tongue Neoplasms Tnf tongue squamous cell carcinoma Birc2 torsion dystonia 6 Ikbkb toxic shock syndrome Tnf trachoma Tnf transient cerebral ischemia Casp8 , Cav1 , Fadd , Ikbkb , Madd , Map3k5 , Map3k7 , Nfkb1 , Rack1 , Tnf , Tnfrsf1a transitional cell carcinoma Cav1 , Tnf Transplant Rejection Ikbkb , Rela , Tnf , Tnfrsf1b , Traf2 traumatic brain injury Rela , Tnf trichinosis Tnf Trichoepithelioma, Multiple Familial, 2 Cyld trigeminal neuralgia Tnf tropical spastic paraparesis Nfkb1 tuberculosis Tnf , Tnfrsf1b tuberous sclerosis 1 Traf2 type 1 diabetes mellitus Casp8 , Tnf type 1 diabetes mellitus 5 Tab2 type 2 diabetes mellitus Adam17 , Casp8 , Ikbkb , Madd , Nfkb1 , Prkci , Prkcz , Rela , Tnf , Tnfrsf1a , Tnfrsf1b typhoid fever Tnf ulcerative colitis Rela , Tnf , Tnfaip3 ureteral obstruction Adam17 , Rela , Tnf , Tnfrsf1a , Tnfrsf1b urinary bladder cancer Birc3 , Cav1 , Map2k7 , Rela , Tnf urticaria Tnf Uterine Cervical Neoplasms Casp8 , Cyld , Rela uveitis Rela , Tnf , Tnfrsf1a vascular dementia Tnf vascular disease Ikbkb , Tnf Vascular System Injuries Tnf Venous Thromboembolism Tnf Ventilator-Induced Lung Injury Map3k5 Ventricular Dysfunction Tnf Ventricular Remodeling Map3k5 verrucous keratotic hemangioma Map3k3 Viral Bronchiolitis Nfkb1 , Tnf Viral Myocarditis Casp8 viral pneumonia Tnf visceral leishmaniasis Tnf visual epilepsy Map3k5 , Tnf , Tnfrsf1a , Tnfrsf1b vitiligo Tnf Vogt-Koyanagi-Harada disease Tnf Vulvar Vestibulitis Tnf Weight Gain Cav1 , Tnf Weill-Marchesani syndrome Tnf Wilson disease Smpd1 , Tnf Wounds and Injuries Tnf X-linked adrenal hypoplasia congenita Tab3