| Term: | increased susceptibility to type II hypersensitivity reaction |
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| Accession: | MP:0005613
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| Definition: | greater likelihood or resistance to developing a response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved |
| Comment: | Examples of this include: autoimmune diseases: autoimmune hemolytic anemias, antibody-dependent cellular cytotoxicity (ADCC), Goodpasture disease, myasthenia gravis, Graves disease, pemphigus, and pemphigoid. |
| Synonyms: | exact_synonym: | decreased resistance to antibody-mediated cellular toxicity; decreased resistance to cytotoxic type hypersensitivity; decreased resistance to type II hypersensitivity reaction; increased susceptibility to antibody-mediated cellular toxicity; increased susceptibility to cytotoxic type hypersensitivity |
