Ontology Browser

Term:
apoptotic process (GO:0006915)
11034 annotations. (View Annotations)
Parent Terms Term With Siblings Child Terms
programmed cell death  +
apoptotic process  +  
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase, and an execution phase, which is triggered by the former.
autophagic cell death  +  
cornification
developmental programmed cell death  +  
host programmed cell death induced by symbiont  +
negative regulation of programmed cell death  +  
positive regulation of programmed cell death  +  
programmed cell death in response to reactive oxygen species  +  
programmed necrotic cell death  +  
pyroptosis  
regulation of programmed cell death  +  
activation of cysteine-type endopeptidase activity involved in apoptotic process  +  
anoikis  +  
apoptotic mitochondrial changes  +  
apoptotic process involved in luteolysis  
apoptotic process involved in metanephric collecting duct development  +  
apoptotic process involved in metanephric nephron tubule development  +  
apoptotic process involved in morphogenesis  +  
apoptotic signaling pathway  +  
cell-type specific apoptotic process  +  
execution phase of apoptosis  +  
fibroblast growth factor receptor signaling pathway involved in apoptotic process
negative regulation of apoptotic process  +  
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  +  
positive regulation of apoptotic process  +  
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  +  
positive regulation of mitochondrial membrane permeability involved in apoptotic process  +  
regulation of apoptotic process  +  
regulation of cysteine-type endopeptidase activity involved in apoptotic process  +  
regulation of mitochondrial membrane permeability involved in apoptotic process  +  

Synonyms
exact_synonym: apoptotic cell death ;   apoptotic programmed cell death ;   programmed cell death by apoptosis
narrow_synonym: apoptosis ;   apoptotic program ;   type I programmed cell death
broad_synonym: cell suicide ;   cellular suicide
related_synonym: signaling (initiator) caspase activity
alt_id: GO:0008632
xref_analog: Reactome:REACT_100045 ;   Reactome:REACT_100962 ;   Reactome:REACT_101249 ;   Reactome:REACT_104187 ;   Reactome:REACT_105149 ;   Reactome:REACT_106405 ;   Reactome:REACT_106672 ;   Reactome:REACT_107264 ;   Reactome:REACT_108651 ;   Reactome:REACT_109165 ;   Reactome:REACT_110081 ;   Reactome:REACT_111964 ;   Reactome:REACT_13526 ;   Reactome:REACT_13638 ;   Reactome:REACT_13643 ;   Reactome:REACT_28087 ;   Reactome:REACT_28795 ;   Reactome:REACT_28816 ;   Reactome:REACT_30266 ;   Reactome:REACT_30361 ;   Reactome:REACT_30371 ;   Reactome:REACT_30548 ;   Reactome:REACT_30763 ;   Reactome:REACT_31349 ;   Reactome:REACT_34139 ;   Reactome:REACT_578 ;   Reactome:REACT_77132 ;   Reactome:REACT_77313 ;   Reactome:REACT_77415 ;   Reactome:REACT_78287 ;   Reactome:REACT_78802 ;   Reactome:REACT_79809 ;   Reactome:REACT_82724 ;   Reactome:REACT_83328 ;   Reactome:REACT_85877 ;   Reactome:REACT_86749 ;   Reactome:REACT_86873 ;   Reactome:REACT_87570 ;   Reactome:REACT_88740 ;   Reactome:REACT_88784 ;   Reactome:REACT_89196 ;   Reactome:REACT_90267 ;   Reactome:REACT_91011 ;   Reactome:REACT_91243 ;   Reactome:REACT_93937 ;   Reactome:REACT_94099 ;   Reactome:REACT_95069 ;   Reactome:REACT_95675 ;   Reactome:REACT_97627 ;   Reactome:REACT_99784 ;   Reactome:REACT_99799 ;   Wikipedia:Apoptosis

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