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Ontology Browser
Term:
thioredoxin-disulfide reductase (NADPH) activity (GO:0004791)
Annotations: Rat: (7) Mouse: (6) Human: (7) Chinchilla: (6) Bonobo: (6) Dog: (6) Squirrel: (6) Pig: (6) Naked Mole-rat: (5) Green Monkey: (8)
Parent Terms Term With Siblings Child Terms
glutathione dehydrogenase (ascorbate) activity  
glutathione-disulfide reductase (NADPH) activity  
peroxidase activity +   
sulfiredoxin activity  
superoxide dismutase activity  
superoxide reductase activity 
thioredoxin-disulfide reductase (NADPH) activity  
Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH.

Synonyms
Exact Synonyms: thioredoxin-disulfide reductase (NADP) activity ;   thioredoxin-disulphide reductase activity
Broad Synonyms: thioredoxin disulfide reductase activity
Related Synonyms: NADPH--thioredoxin reductase activity ;   NADPH:oxidized thioredoxin oxidoreductase activity
Xrefs: EC:1.8.1.9 ;   KEGG_REACTION:R02016 ;   MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN ;   RHEA:20345 ;   reactome:R-HSA-1222485 "TrxB reactivates TrxA" ;   reactome:R-HSA-3323050 "TXNRD2 catalyzes the reduction of TXN2 by NADPH" ;   reactome:R-HSA-73646 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+" ;   reactome:R-HSA-9617735 "TXN disrupts FOXO4 complex with EP300"
Definition Sources: RHEA:20345

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