vardenafil - Ontology Browser - Rat Genome Database

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Keyword

ONTOLOGY BROWSER

Term:	vardenafil	go back to main search page
Accession:	CHEBI:46295	browse the term view annotations
Definition:	The sulfonamide resulting from formal condensation of the sulfo group of 4-ethoxy-3-(5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one-2-yl)benzenesulfonic acid and the secondary amino group of 4-ethylpiperazine.
Synonyms:	related_synonym:	2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE; C23H32N6O4S; CCCc1nc(C)c2n1[nH]c(nc2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1; InChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30); InChIKey=SECKRCOLJRRGGV-UHFFFAOYSA-N; Levitra
	xref_casrn:	224785-90-4
	xref:	Beilstein:9967331 "Beilstein Registry Number"; ChEMBL:521326 "ChEMBL COMPOUND"; ChemIDplus:224785-90-4 "CAS Registry Number"; CiteXplore:19949666 "PubMed citation"; CiteXplore:19959201 "PubMed citation"; CiteXplore:20859794 "PubMed citation"; CiteXplore:20925442 "PubMed citation"; CiteXplore:21209618 "PubMed citation"; CiteXplore:21235726 "PubMed citation"; CiteXplore:21290241 "PubMed citation"; CiteXplore:21427994 "PubMed citation"; CiteXplore:21496853 "PubMed citation"; CiteXplore:21548209 "PubMed citation"; CiteXplore:21552528 "PubMed citation"; CiteXplore:21771280 "PubMed citation"; CiteXplore:21883954 "PubMed citation"; CiteXplore:21943935 "PubMed citation"; CiteXplore:21950284 "PubMed citation"; DrugBank:DB00862 "DrugBank"; KEGG DRUG:D08668 "KEGG DRUG"
	xref_mesh:	MESH:C426063
	xref:	PDBeChem:VDN "PDBeChem"; Reaxys:9967331 "Reaxys Registry Number"; Wikipedia:Vardenafil "Wikipedia"

Parent Terms	Term With Siblings	Child Terms
imidazotriazine + N-alkylpiperazine + N-sulfonylpiperazine + phosphodiesterase inhibitor + vasodilator agent +	(2R,3S)-EHNA (2R,3S)-EHNA hydrochloride (2R,4S)-N-[(1S,2R)-2-hydroxyindan-1-yl]-2-phenylmethyl-4-hydroxy-5-[(2S)-4-(benzofuran-2-ylmethyl)-2-(tert-butylaminocarbonyl)piperazin-1-yl]pentanamide (2R,4S)-N-[(1S,2R)-2-hydroxyindan-1-yl]-5-[(2S)-2-(tert-butylaminocarbonyl)-4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4-hydroxy-2-(phenylmethyl)pentanamide (2S)-4-[(6-chloronaphthalen-2-yl)sulfonyl]-1-[(1-pyridin-4-ylpiperidin-4-yl)methyl]piperazine-2-carboxylic acid (2S,4S,5S)-5-[((2S)-2-\{(3R)-3-benzyl-4-[(4-methylpiperazin-1-yl)carbonyl]-2-oxopiperazin-1-yl\}hexanoyl)amino]-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide (6R)-4-[(6-chloronaphthalen-2-yl)sulfonyl]-6-(morpholin-4-ylcarbonyl)-1-[(1-pyridin-4-ylpiperidin-4-yl)methyl]piperazin-2-one (R)-adrenaline + (S)-4,4'-(1-methylethane-1,2-diyl)bis(piperazine-2,6-dione) 1,3-bis-([3-(4-\{3-[3-nitro-5-(galactopyranosyloxy)benzoylamino]propyl\}piperazin-1-yl)propylamino]carbonyloxy)-2-aminopropane 1,3-bis-([3-[3-[3-(4-\{3-[3-nitro-5-(galactopyranosyloxy)benzoylamino]propyl\}piperazin-1-yl)propylamino-3,4-dioxocyclobutenyl]aminopropoxyethoxyethoxy]propyl]aminocarbonyloxy)-2-aminopropane 1,3-bis-([[3-(4-\{3-[3-nitro-5-(galactopyranosyloxy)benzoylamino]propyl\}piperazin-1-yl)propylamino-3,4-dioxocyclobutenyl]aminoethyl]aminocarbonyloxy)-2-aminopropane 1-(3,4-dihydroxy-5-nitrophenyl)-3-\{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl\}propan-1-one 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine 1-[2-hydroxy-4-(2-hydroxy-5-methylcyclopentylcarbamoyl)-5-phenylpentyl]-4-(3-pyridin-3-ylpropionyl)piperazine-2-(N-tert-butyl)carboxamide 1-\{[(E)-2-(4-chlorophenyl)ethenyl]sulfonyl\}-4-[(1-pyridin-4-ylpiperidin-4-yl)methyl]piperazine 2,3-diphenyl-N-(2-piperazin-1-ylethyl)furo[2,3-b]pyridin-4-amine 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine 3-(galactopyranosyloxy)-N-(3-\{4-[3-(\{2-[(3-\{4-[3-(\{[3-(galactopyranosyloxy)-5-nitrophenyl]carbonyl\}amino)propyl]piperazin-1-yl\}propyl)amino]-3,4-dioxocyclobut-1-en-1-yl\}amino)propyl]piperazin-1-yl\}propyl)-5-nitrobenzamide 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol 3-methylflavone-8-carboxylic acid + 4,4'-propane-1,3-diyldipiperazine-2,6-dione 4-(\{4-[(6-chloronaphthalen-2-yl)sulfonyl]-2-oxopiperazin-1-yl\}methyl)-1-pyridin-4-ylpiperidine-4-carbaldehyde oxime 4-[(6-chloronaphthalen-2-yl)sulfonyl]-1-[(1-pyridin-4-ylpiperidin-4-yl)methyl]piperazin-2-one 4-[(6-chloronaphthalen-2-yl)sulfonyl]-1-\{[4-(hydroxymethyl)-1-pyridin-4-ylpiperidin-4-yl]methyl\}piperazin-2-one 4-[4-(biphenyl-2-ylmethyl)piperazin-1-yl]-N-[4-\{[1,1-dimethyl-2-(phenylthio)ethyl]amino\}-3-nitrobenzenesulfonyl]benzamide 4-\{[(E)-2-(4-chlorophenyl)ethenyl]sulfonyl\}-1-[(1-pyridin-4-ylpiperidin-4-yl)methyl]piperazin-2-one 4-fluoro-N-\{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl\}benzamide 5,6-diphenyl-N-(2-piperazin-1-ylethyl)furo[2,3-d]pyrimidin-4-amine 5-(2-methylpiperazine-1-sulfonyl)isoquinoline 6,7-dimethoxy-4-\{8-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydroisoquinolin-2-(1H)-yl\}quinazoline 6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)ethyl]-9H-purine-2-carbonitrile 6-\{4-[(4-ethylpiperazin-1-yl)methyl]phenyl\}-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 7-epiclusianone 9-cyclopentyl-6-\{2-[3-(4-methylpiperazin-1-yl)propoxy]phenylamino\}-9H-purine-2-carbonitrile acetophenazine + acetylcholine + adenosine + adenosine phosphodiesterase inhibitor + amlodipine + amlodipine benzenesulfonate aripiprazole avanafil bamethan + benzyl (3R)-3-[(hydroxyamino)carbonyl]-4-[(4-methoxyphenyl)sulfonyl]piperazine-1-carboxylate benzyl \{(1S)-5-amino-1-[(S)-hydroxy(5-\{[4-(4-phenylbutanoyl)piperazin-1-yl]methyl\}-1,2,4-oxadiazol-3-yl)methyl]pentyl\}carbamate bepridil + betahistine BGJ-398 bucladesine buclizine buspirone + caffeine + carphenazine + carvedilol cilostazol cinnamaldehyde + cinnarizine clopenthixol + convallatoxin cyclandelate cyclizine + dapiprazole diazoxide dihydroergocristine + dihydroergocristine mesylate + diltiazem + diltiazem hydrochloride dipyridamole doxazosin + DPCPX dyphylline + EHNA + enrofloxacin ergoloid mesylate erythrityl tetranitrate ethyl (2R)-4-[(6-chloronaphthalen-2-yl)sulfonyl]-1-[(1-pyridin-4-ylpiperidin-4-yl)methyl]piperazine-2-carboxylate ethyl (2R)-4-[(6-chloronaphthalen-2-yl)sulfonyl]-6-oxo-1-[(1-pyridin-4-ylpiperidin-4-yl)methyl]piperazine-2-carboxylate felodipine fenoldopam flupenthixol fluphenazine GR 127935 graminone B hydralazine + hydralazine hydrochloride hydrogen sulfide + hydroxyzine + Ile(5)-angiotensin II (1-7) iloprost isoamyl nitrite isosorbide dinitrate isosorbide mononitrate levosimendan linkable imatinib analogue masitinib methacholine + methiothepin methyl brevifolincarboxylate metofenazate milrinone minoxidil N-(2-hydroxyethyl)piperazine + N-(2-hydroxyindan-1-yl)-5-[2-(tert-butylaminocarbonyl)-4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4-hydroxy-2-(1-phenylethyl)pentanamide N-(2-hydroxyindan-1-yl)-5-[2-(tert-butylaminocarbonyl)-4-(3-pyridylmethyl)piperazin-1-yl]-4-hydroxy-2-(1-phenylethyl)pentanamide N-(4-\{1-[4-(4-acetylpiperazin-1-yl)-trans-cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl\}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide N-(4-\{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl\}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide N-(sulfoalkyl)piperazine + N-\{3-[4-(3-aminopropyl)piperazin-1-yl]propyl\}-3-(2-thiophen-2-ylacetylamino)-5-(3,4,5-trihydroxy-6-hydroxymethyltetrahydropyran-2-yloxy)benzamide N-\{3-[4-(3-aminopropyl)piperazin-1-yl]propyl\}-3-nitro-5-(D-galactopyranosyl)benzamide + N-ethyl-5'-carboxamidoadenosine N-methylpiperazine + N-methylquipazine + n-pentyl nitrite NAN 190 nebivolol nefazodone + nicotinic acid + nifedipine nimodipine nitric oxide nitroglycerin ofloxacin + partial prostacyclin agonist + pefloxacin + pentaerythritol tetranitrate perazine perphenazine + phosphodiesterase III inhibitor + phosphodiesterase IV inhibitor + phosphodiesterase V inhibitor + pimobendan pindolol + prochlorperazine + propranolol + prostaglandin E1 + quetiapine + razoxane + rifapentine rolipram + SDZ 35-682 sildenafil + sildenafil citrate sphingosine 1-phosphate sulmazole tadalafil theobromine theophylline + thiopropazate thioproperazine tolazoline trazodone + treprostinil + trifluoperazine + trimethaphan + troglitazone vanoxerine vardenafil The sulfonamide resulting from formal condensation of the sulfo group of 4-ethoxy-3-(5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one-2-yl)benzenesulfonic acid and the secondary amino group of 4-ethylpiperazine. verapamil + vilazodone vincamine zardaverine

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